CN1513461A - Feeze-dried powder injection contg. tatol saponin by refinement of American ginseng and leaves and stem of Americal ginseng, and its prodn. process - Google Patents
Feeze-dried powder injection contg. tatol saponin by refinement of American ginseng and leaves and stem of Americal ginseng, and its prodn. process Download PDFInfo
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- CN1513461A CN1513461A CNA031276326A CN03127632A CN1513461A CN 1513461 A CN1513461 A CN 1513461A CN A031276326 A CNA031276326 A CN A031276326A CN 03127632 A CN03127632 A CN 03127632A CN 1513461 A CN1513461 A CN 1513461A
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- panacis quinquefolii
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- 229930182490 saponin Natural products 0.000 title claims abstract description 47
- 150000007949 saponins Chemical class 0.000 title claims abstract description 47
- 239000000843 powder Substances 0.000 title claims abstract description 35
- 238000002347 injection Methods 0.000 title claims abstract description 20
- 239000007924 injection Substances 0.000 title claims abstract description 20
- 239000001397 quillaja saponaria molina bark Substances 0.000 title claims abstract description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 title abstract description 4
- 240000005373 Panax quinquefolius Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title description 5
- 241000208340 Araliaceae Species 0.000 title description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title description 2
- 235000008434 ginseng Nutrition 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 96
- 239000011347 resin Substances 0.000 claims abstract description 34
- 229920005989 resin Polymers 0.000 claims abstract description 34
- 238000001914 filtration Methods 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- 238000004108 freeze drying Methods 0.000 claims abstract description 3
- 235000017709 saponins Nutrition 0.000 claims description 45
- 239000000243 solution Substances 0.000 claims description 38
- 238000007670 refining Methods 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 23
- 238000005516 engineering process Methods 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000003480 eluent Substances 0.000 claims description 15
- 238000004064 recycling Methods 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 230000006837 decompression Effects 0.000 claims description 7
- 238000010828 elution Methods 0.000 claims description 7
- 239000012982 microporous membrane Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 230000000274 adsorptive effect Effects 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000000859 sublimation Methods 0.000 claims description 5
- 230000008022 sublimation Effects 0.000 claims description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- 239000003463 adsorbent Substances 0.000 claims description 2
- 239000003957 anion exchange resin Substances 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims description 2
- 239000003456 ion exchange resin Substances 0.000 claims description 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 description 6
- 210000004165 myocardium Anatomy 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 4
- 150000003648 triterpenes Chemical class 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 229940039009 isoproterenol Drugs 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 235000002791 Panax Nutrition 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 208000013433 lightheadedness Diseases 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000005837 radical ions Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A freeze dried common saponin injection of American ginseng or its stem and leaf is prepared through breaking, decocting, collecting decoction, concentrating, adding alcohol, filtering, recovering alcohol, regulating pH, laying aside, filtering, macroreticular resin adsorption, eluting, collecting eluting liquid, flowing through another two resin columns, recovering alcohol, concentrating, drying to obtain powder, dissolving in alcohol, decoloring, filtering, sterilizing and freeze drying. Its advantage is high purity up to 90% or more.
Description
Technical field:
The present invention discloses a kind of Radix Panacis Quinquefolii and refining saponins freeze-dried powder injection of stem and leaf of Radix Panacis Quinquefolii and production technology, relate to the new technology of refining saponins freeze-dried powder injection of preparation Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii and Radix Panacis Quinquefolii and the refining total saponins of stem and leaf of Radix Panacis Quinquefolii, belong to field of medicine preparations.
Background technology:
Radix Panacis Quinquefolii (panax quinguefolium Lima.) contains multiple identical Radix Ginseng total saponins with stem and leaf of Radix Panacis Quinquefolii, shows that after deliberation the stem and leaf of Radix Panacis Quinquefolii total saponins has the rat heart muscle ischemia that experimental myocardial infarction and isoproterenol are brought out and has significant protective effect; Can increase the anoxybiotic ability of cardiac muscle tolerance; Can increase the blood flow of animal cardiac muscle significantly and reduce physiologically actives such as coronary resistance, be traditional Chinese medicine.With Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii is that injection Radix Panacis Quinquefolii and the refining total saponins of stem and leaf of Radix Panacis Quinquefolii that effective ingredient is made has supplementing QI and nourishing YIN, blood circulation and channel invigorating, the effect of the relieving restlessness of promoting the production of body fluid clinically.Be used for the treatment of angina pectoris, card is seen sensation of oppression and faint pain in the chest, shortness of breath and palpitation, tiredness with no desire to speak, Light-headedness, syndrome of deficiency of both qi and yin such as spontaneous perspiration dry pharynx.Be used for the treatment of the treatment of diseases such as the heart, cerebrovascular disease, aging, hyperlipidemia and immunologic hypofunction.
At present, owing to do not use the filter process of greater efficiency in the technology of production Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii total saponins, do not adopt highly effective method precipitated impurities yet, there is not the adjusting of PH when reclaiming ethanol, through not further decolouring behind the resin column, thereby the total saponin content of Radix Panacis Quinquefolii of producing and stem and leaf of Radix Panacis Quinquefolii total saponins is on the low side, and total saponin content only reaches 50%-75%, the impurity level height that is contained; Preparation technology in the past remains the use at the leaching process organic solvent, causes the cost height, and suitability for industrialized production is dangerous strong, is unfavorable for suitability for industrialized production.
Summary of the invention:
The invention provides the refining triterpenes freeze-dried powder pin of a kind of production Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii, also provide it to produce the extracting method of total saponins in good Radix Panacis Quinquefolii of the refining total saponins purity high stability of a kind of Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii and the refining triterpenes freeze-dried powder pin of stem and leaf of Radix Panacis Quinquefolii simultaneously, can make that total saponin content reaches more than 90% in the refining total saponins, and avoid using high concentration alcohol or organic solvent, be suitable for enterprise's suitability for industrialized production, the refining triterpenes freeze-dried powder pin product impurity content that this preparation method makes is low, and total saponin content is up to more than 90%.
For achieving the above object, the present invention adopts following design: a kind of production Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii are made with extra care triterpenes freeze-dried powder pin technology:
(1) Radix Panacis Quinquefolii or stem and leaf of Radix Panacis Quinquefolii pulverizing are coarse powder, in the boiling water of 16～22 times of weight, decoct 2-3 time each 1-2 hour;
(2) merge each time extracting solution, relative density is 1.00-1.20 when being concentrated into 30 ℃-80 ℃;
(3) add ethanol in the concentrated solution, make that ethanol content reaches 60%-85% in the solution, filter;
(4) with decompression filtrate recycling ethanol, and the pH value of regulator solution is placed filtration to 8-14;
(5) above-mentioned filtrate is passed through macroporous adsorptive resins I,, discard eluent, with 40%-90% concentration alcohol eluting, collection eluent with 0%-40% alcohol eluting resin column;
(6) eluent passes through ion exchange resin post II and decolorizing resin post III, and effluent reclaim under reduced pressure alcohol is concentrated, dry, gets dry powder;
(7) dry powder is used the 0%-85% dissolve with ethanol solution, be mixed with 5% total saponins solution, add the medicinal carbon of 0.25%-2%, reflux 30 minutes to 2 hours;
(8) filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and is dried to dry powder (total saponin content reaches 90%);
(9) above-mentioned refining total saponins is added the injection water and be mixed with 5% aqueous solution, with Φ 0.20-0.80 micron filtering with microporous membrane;
(10) with the filled with solution behind the above-mentioned fine straining, sterilization back lyophilizing gets Radix Panacis Quinquefolii and the refining saponins freeze-dried powder injection of stem and leaf of Radix Panacis Quinquefolii.
Relative density is 1.00-1.20 when in the step of production technology of the present invention (2) extracting solution being concentrated into 30 ℃-80 ℃.
Add in the step (3) behind the ethanol that ethanol content is 70% in the solution.
The concentrated solution pH value is adjusted to 11 in the step (4).
Macroporous resin column I comprises D21, AB-8, D101, DA-201 model in the step (5), and macroporous adsorbent resin continues and uses 70% ethanol elution earlier with 20% ethanol elution.
Resin column II is the large hole cation exchanger resin post in the step (6), and post III is an anion-exchange resin column.
Dry powder is dissolved in 70% ethanol and is mixed with 5% total saponins solution and adds 1% active carbon in the step (7), refluxes and makes with extra care in 1 hour.
The refining total saponins of step (9) adds the injection water and is mixed with 5% aqueous solution with using 0.20 micron filtering with microporous membrane of Φ.
Step (10) lyophilisation condition is-30～-50 ℃ of pre-freezes after 3～7 hours, a sublimation drying.
Good effect of the present invention is: successfully used ethanol precipitation and alkali precipitation in the production process, impurity in the solution has been reduced significantly played pivotal role; In addition will be through the alcoholic solution of macroporous adsorptive resins, once more by other two radical ions resin column, further remove more impurity, elimination to impurity plays a positive role, the net content of the extract effective ingredient total saponins that obtains is increased substantially, make the effective ingredient total saponin content up to more than 90%.
Show that after deliberation the refining total saponins powder needle set of injection Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii has the rat heart muscle ischemia that experimental myocardial infarction and isoproterenol are brought out to have significant protective effect; Can increase the anoxybiotic ability of cardiac muscle tolerance; Can increase the blood flow of animal cardiac muscle significantly and reduce physiologically actives such as coronary resistance.Prove that this medicine is one and good has a supplementing QI and nourishing YIN, blood circulation and channel invigorating, the relieving restlessness medicine that promotes the production of body fluid is the active drug of the treatment heart, cerebrovascular disease, aging, hyperlipidemia and immunologic hypofunction etc.
The specific embodiment:
Embodiment 1:
The preparation of the refining total saponins of stem and leaf of Radix Panacis Quinquefolii
(1) gets the water that stem and leaf of Radix Panacis Quinquefolii 1kg adds an amount of 16kg, heated and boiled 2 times, each 1.0 hours;
(2) the water extract of collection and merging gained, being concentrated into 50 ℃ of relative densities is 1.10 Baumes;
(3) add ethanol in the concentrated solution, make that ethanol content reaches 80% in the solution, filter filtrate recycling ethanol;
(4) above-mentioned filtrate is regulated pH value to 10, place, filter;
(5) with filtrate by the D21 macroporous adsorptive resins, use 10% ethanol-eluting resin column, be eluted to respectively eluent colourless after, discard eluent, with 80% concentration ethanol eluting resin column, the collection eluent;
(6) 80% ethanol elution are by cationic resin column and resin anion (R.A.) post, and reclaim under reduced pressure alcohol is condensed into extractum shape or dry powder;
(7) dry powder is used 70% dissolve with ethanol solution, be mixed with 5% total saponins solution, add 1% medicinal carbon, reflux 1 hour,
(8) filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and is dried to dry powder (total saponin content reaches 93%).
(9) above-mentioned refining total saponins is added the injection water and be mixed with 5% aqueous solution, 0.20 micron filtering with microporous membrane of Φ;
(10) with the filled with solution behind the above-mentioned fine straining ,-40 ℃ of pre-freezes in sterilization back are after 3 hours, and one time sublimation drying gets the refining saponins freeze-dried powder injection of stem and leaf of Radix Panacis Quinquefolii
Embodiment 2
(1) gets the water that stem and leaf of Radix Panacis Quinquefolii 1kg adds an amount of 18kg, heated and boiled 3 times, each 1.5 hours;
(2) the water extract of collection and merging gained, being concentrated into 80 ℃ of relative densities is 1.15;
(3) add ethanol in the concentrated solution, make that ethanol content reaches 70% in the solution, filter filtrate recycling ethanol;
(4) above-mentioned filtrate is regulated pH value to 11, place, filter;
(5) with filtrate by the AB-8 macroporous adsorptive resins, use 30% ethanol-eluting resin column, be eluted to respectively eluent colourless after, discard eluent, with 65% concentration ethanol eluting resin column, the collection eluent;
(6) 65% ethanol elution are by cationic resin column and resin anion (R.A.) post, and reclaim under reduced pressure alcohol is condensed into extractum shape or dry powder;
(7) dry powder is dissolved with water for injection, be mixed with 5% total saponins solution, add 0.5% medicinal carbon, reflux 30 minutes;
(8) filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and is dried to dry powder (total saponin content reaches 95%).
(9) above-mentioned refining total saponins is added the injection water and be mixed with 5% aqueous solution, 0.60 micron filtering with microporous membrane of Φ;
(10) with the filled with solution behind the above-mentioned fine straining ,-45 ℃ of pre-freezes in sterilization back are after 4 hours, and one time sublimation drying gets the refining saponins freeze-dried powder injection of stem and leaf of Radix Panacis Quinquefolii
Embodiment 3
(1) gets the water that stem and leaf of Radix Panacis Quinquefolii 1kg adds 22kg, heated and boiled 3 times, each 1.5 hours;
(2) the water extract of collection and merging gained, being concentrated into 80 ℃ of relative densities is 1.20;
(3) add ethanol in the concentrated solution, make that ethanol content reaches 65% in the solution, filter filtrate recycling ethanol;
(4) above-mentioned filtrate is regulated pH value to 12, place, filter;
(5) with filtrate by the D21 macroporous adsorptive resins, use 20% ethanol-eluting resin column, be eluted to respectively eluent colourless after, discard eluent, with 70% concentration ethanol eluting resin column, the collection eluent;
(6) 70% ethanol elution are by cationic resin column and resin anion (R.A.) post, and reclaim under reduced pressure alcohol is condensed into extractum shape or dry powder;
(7) dry powder is used 75% dissolve with ethanol solution, be mixed with 5% total saponins solution, add 1.5% medicinal carbon, reflux 30 minutes;
(8) filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and is dried to dry powder (total saponin content reaches 98%).
(9) above-mentioned refining total saponins is added the injection water and be mixed with 5% aqueous solution, 0.45 micron filtering with microporous membrane of Φ;
(10) with the filled with solution behind the above-mentioned fine straining ,-50 ℃ of pre-freezes in sterilization back are after 4 hours, and one time sublimation drying gets the refining saponins freeze-dried powder injection of stem and leaf of Radix Panacis Quinquefolii.
Claims (10)
1, the refining saponins freeze-dried powder injection production technology of a kind of Radix Panacis Quinquefolii and stem and leaf of Radix Panacis Quinquefolii is characterized in that may further comprise the steps:
(1) Radix Panacis Quinquefolii or stem and leaf of Radix Panacis Quinquefolii pulverizing are coarse powder, in the boiling water of 16～22 times of weight, decoct 2-3 time each 1-2 hour;
(2) merge each time extracting solution, relative density is 1.00-1.20 when being concentrated into 30 ℃-80 ℃;
(3) add ethanol in the concentrated solution, make that ethanol content reaches 60%-85% in the solution, filter;
(4) with decompression filtrate recycling ethanol, and the pH value of regulator solution is placed filtration to 8-14;
(5) above-mentioned filtrate is passed through macroporous adsorptive resins I,, discard eluent, with 40%-90% concentration alcohol eluting, collection eluent with 0%-40% alcohol eluting resin column;
(6) eluent passes through ion exchange resin post II and decolorizing resin post III, and effluent reclaim under reduced pressure alcohol is concentrated, dry, gets dry powder;
(7) dry powder is used the 0%-85% dissolve with ethanol solution, be mixed with 5% total saponins solution, add the medicinal carbon of 0.25%-2%, reflux 30 minutes to 2 hours,
(8) filter while hot, fine straining again, decompression filtrate recycling ethanol concentrates and is dried to dry powder (total saponin content reaches 90%).
(9) above-mentioned refining total saponins is added the injection water and be mixed with 5% aqueous solution, with Φ 0.20-0.80 micron filtering with microporous membrane;
(10) with the filled with solution behind the above-mentioned fine straining, sterilization back lyophilizing gets Radix Panacis Quinquefolii and the refining saponins freeze-dried powder injection of stem and leaf of Radix Panacis Quinquefolii.
2, the described production technology of claim 1 is characterized in that: relative density is 1.00-1.20 when in the step (2) extracting solution being concentrated into 30 ℃-80 ℃.
3, the described production technology of claim 1 is characterized in that: add in the step (3) behind the ethanol that ethanol content is 70% in the solution.
4, the described production technology of claim 1 is characterized in that: it is characterized in that the concentrated solution pH value is adjusted to 11 in the step (4).
5, the described production technology of claim 1 is characterized in that: macroporous resin column comprises D21, AB-8, D101, DA-201 model in the step (5), and macroporous adsorbent resin continues and uses 70% ethanol elution earlier with 20% ethanol elution.
6, the described production technology of claim 1 is characterized in that: resin column II is the large hole cation exchanger resin post in the step (6), and post III is an anion-exchange resin column.
7, the described production technology of claim 1 is characterized in that: dry powder is dissolved in 70% ethanol and is mixed with 5% total saponins solution and adds 1% active carbon in the step (7), refluxes and makes with extra care in 1 hour.
8, the described production technology of claim 1 is characterized in that: the refining total saponins of step (9) adds the injection water and is mixed with 5% aqueous solution with using 0.20 micron filtering with microporous membrane of Φ.
9, the described production technology of claim 1 is characterized in that: step (10) lyophilisation condition is-30～-50 ℃ of pre-freezes after 3～7 hours, a sublimation drying.
10, the product of claim 1 to 9 production technology production.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03127632 CN1221267C (en) | 2003-07-17 | 2003-07-17 | Feeze-dried powder injection contg. tatol saponin by refinement of American ginseng and leaves and stem of Americal ginseng, and its prodn. process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03127632 CN1221267C (en) | 2003-07-17 | 2003-07-17 | Feeze-dried powder injection contg. tatol saponin by refinement of American ginseng and leaves and stem of Americal ginseng, and its prodn. process |
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| Publication Number | Publication Date |
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| CN1513461A true CN1513461A (en) | 2004-07-21 |
| CN1221267C CN1221267C (en) | 2005-10-05 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305894C (en) * | 2003-10-17 | 2007-03-21 | 成都华森药物高新技术有限公司 | Process for extracting total saponin of American ginseng and powder injection thereof |
| CN1919251B (en) * | 2005-08-24 | 2010-11-03 | 天津天士力制药股份有限公司 | Traditional Chinese medicine composition for treating cardiac vascular disease |
| CN101084929B (en) * | 2006-06-08 | 2011-09-21 | 天津天士力之骄药业有限公司 | Method for extracting saponins of traditional Chinese medicine |
| CN102293802A (en) * | 2010-06-25 | 2011-12-28 | 吉林省集安益盛药业股份有限公司 | Medicinal composition for treating cardiovascular diseases and preparation method thereof |
| CN101084955B (en) * | 2006-06-08 | 2012-02-01 | 天津天士力之骄药业有限公司 | Method for preparing total ginsenoside |
| CN105473006A (en) * | 2014-04-16 | 2016-04-06 | 花王株式会社 | Method for producing carrot extract |
| CN110585260A (en) * | 2019-10-31 | 2019-12-20 | 北京本草方源药业集团有限公司 | Single-ingredient freeze-dried powder and preparation method thereof |
| CN111297879A (en) * | 2020-03-24 | 2020-06-19 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | Application of conversion type ginsenoside in preparing hypolipidemic drugs |
| WO2020192163A1 (en) * | 2019-03-28 | 2020-10-01 | 泰州医药城国科化物生物医药科技有限公司 | Refined american ginseng total saponin component and method for purifying and preparing american ginseng total saponin |
-
2003
- 2003-07-17 CN CN 03127632 patent/CN1221267C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305894C (en) * | 2003-10-17 | 2007-03-21 | 成都华森药物高新技术有限公司 | Process for extracting total saponin of American ginseng and powder injection thereof |
| CN1919251B (en) * | 2005-08-24 | 2010-11-03 | 天津天士力制药股份有限公司 | Traditional Chinese medicine composition for treating cardiac vascular disease |
| CN101084929B (en) * | 2006-06-08 | 2011-09-21 | 天津天士力之骄药业有限公司 | Method for extracting saponins of traditional Chinese medicine |
| CN101084955B (en) * | 2006-06-08 | 2012-02-01 | 天津天士力之骄药业有限公司 | Method for preparing total ginsenoside |
| CN102293802A (en) * | 2010-06-25 | 2011-12-28 | 吉林省集安益盛药业股份有限公司 | Medicinal composition for treating cardiovascular diseases and preparation method thereof |
| CN102293802B (en) * | 2010-06-25 | 2014-06-18 | 吉林省集安益盛药业股份有限公司 | Medicinal composition for treating cardiovascular diseases and preparation method thereof |
| CN105473006A (en) * | 2014-04-16 | 2016-04-06 | 花王株式会社 | Method for producing carrot extract |
| WO2020192163A1 (en) * | 2019-03-28 | 2020-10-01 | 泰州医药城国科化物生物医药科技有限公司 | Refined american ginseng total saponin component and method for purifying and preparing american ginseng total saponin |
| CN110585260A (en) * | 2019-10-31 | 2019-12-20 | 北京本草方源药业集团有限公司 | Single-ingredient freeze-dried powder and preparation method thereof |
| CN111297879A (en) * | 2020-03-24 | 2020-06-19 | 深圳市药品检验研究院（深圳市医疗器械检测中心） | Application of conversion type ginsenoside in preparing hypolipidemic drugs |
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