CN1430996A - Oral prepn. of big bupleurum root and its prodn. methods - Google Patents
Oral prepn. of big bupleurum root and its prodn. methods Download PDFInfo
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- CN1430996A CN1430996A CN 03112711 CN03112711A CN1430996A CN 1430996 A CN1430996 A CN 1430996A CN 03112711 CN03112711 CN 03112711 CN 03112711 A CN03112711 A CN 03112711A CN 1430996 A CN1430996 A CN 1430996A
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- oral
- oral formulations
- radix bupleuri
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- radix
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- 238000000034 method Methods 0.000 title claims description 15
- 241000202726 Bupleurum Species 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 claims abstract description 37
- 239000003814 drug Substances 0.000 claims abstract description 10
- 241000207929 Scutellaria Species 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims abstract description 3
- 238000009472 formulation Methods 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000012141 concentrate Substances 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 8
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 7
- 229940126678 chinese medicines Drugs 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 6
- 238000002481 ethanol extraction Methods 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 238000005189 flocculation Methods 0.000 claims description 4
- 230000016615 flocculation Effects 0.000 claims description 4
- 239000013049 sediment Substances 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 229940100691 oral capsule Drugs 0.000 claims description 2
- 229940096978 oral tablet Drugs 0.000 claims description 2
- 239000007935 oral tablet Substances 0.000 claims description 2
- 238000007560 sedimentation technique Methods 0.000 claims description 2
- 201000001352 cholecystitis Diseases 0.000 abstract description 5
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 description 12
- 239000000706 filtrate Substances 0.000 description 12
- 238000010438 heat treatment Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 210000000941 bile Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000037767 Gallbladder pain Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000020694 gallbladder disease Diseases 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
An oral-applied Chinese medicine in the form of liquid for treating acute and chronic cholecystitis is prepared from 8 Chinese-medicinal materials including bupleurum root, scutellaria root, white peony root, ginger, etc through extracting liquid and purifying.
Description
Technical field:
The present invention relates to a kind of Chinese patent medicine.
Background technology:
Cholecystitis is because biliary system is subjected to the invasion and attack of antibacterial, calculus, chemokines etc., causes the gallbladder disease of pathological change, and according to the preliminary statistics, there is patient more than 2,000 ten thousand in the whole nation.Though the Chinese and western drugs of some treatment cholecystitis is arranged on the market,, has certain defective at aspects such as using method, therapeutic effect owing to reasons such as its prescription, dosage forms.
Summary of the invention:
The object of the present invention is to provide a kind of taking convenience, effective big Radix Bupleuri oral formulations and the production method thereof of treatment cholecystitis.
Technical solution of the present invention is:
A kind of big Radix Bupleuri oral formulations, its feature: make by containing following materials of weight proportions:
Radix Bupleuri 15～22% Radix Scutellariaes 8～14%
The Radix Paeoniae Alba 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s 8～14%
Fructus Aurantii Immaturus (parched) 8～14% Radix Et Rhizoma Rhei 6～10%
Rhizoma Zingiberis Recens 5～20% Fructus Jujubaes 10～16%.
Oral formulations is granule or tablet, capsule, oral liquid.
A kind of production method of big Radix Bupleuri oral formulations is characterized in that: comprise the following steps:
1. with the Radix Et Rhizoma Rhei of 6～10% weight portions, use ethanol extraction, collect extracting solution;
2. with 15～22% Radix Bupleuri, 8～14% Radix Scutellariae, 8～14% the Radix Paeoniae Alba, 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 8～14% Fructus Aurantii Immaturus (parched), 15～20% Rhizoma Zingiberis Recens, 10～16% Fructus Jujubae seven flavor Chinese medicines, obtain extracting solution with decoction and alcohol sedimentation technique;
3. with step 1., the extracting solution that 2. obtains merges, and reclaims ethanol, obtains medicinal liquid;
4. will produce oral formulations through the 3. medicinal liquid of gained.
The method that 4. step produces oral granular formulation is: medicinal liquid is concentrated into clear paste, and the qinghuo reagent spray drying gets the medicine dried cream powder, again dried cream powder is made granule, promptly gets oral granular formulation.
The method that 4. step produces oral tablet or capsule is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution, and with the refined solution concentrate drying extract that must loosen, the extract that will loosen is again made tablet or capsule.
The method that 4. step produces oral liquid is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution, with refined solution concentrate clear paste, again this clear paste is mixed with oral liquid.
The present invention can effectively treat acute and chronic cholecystitis, Chinese medicine preparation sheerly, it is a kind of new oral Chinese medicine preparation that develops according to tcm theory and modern Chinese medicine preparation technique, clinical trial shows that the gallbladder pain that hot plate, acetic acid are caused has tangible antagonism, it is swollen to suppress rat granuloma, bile flow after the obvious increase administration, total bilirubin, cholesterol, bile acid content in the slight reduction bile, escherichia coli growths there is protective effect, the mice of coli-infection is had protective effect; Toxicological test shows that said preparation safety has no side effect in addition; Adopt the dosage form of modern Chinese medicine, taking convenience; Manufacture method is simple, cost is low.
The specific embodiment:
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
1. with the Radix Et Rhizoma Rhei of 6% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 21% Radix Bupleuri, 8% Radix Scutellariae, 10% the Radix Paeoniae Alba, 12% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 14% Fructus Aurantii Immaturus (parched), 19% Rhizoma Zingiberis Recens, 10% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. above-mentioned medicinal liquid is concentrated into clear paste, qinghuo reagent is spray drying according to a conventional method, gets the medicine dried cream powder, again dried cream powder is made granule according to a conventional method, promptly gets oral granular formulation.
Embodiment 2:
1. with the Radix Et Rhizoma Rhei of 8% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 18% Radix Bupleuri, 12% Radix Scutellariae, 14% the Radix Paeoniae Alba, 10% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 8% Fructus Aurantii Immaturus (parched), 15% Rhizoma Zingiberis Recens, 15% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. with above-mentioned medicinal liquid with conventional resin adsorption method (or conventional membrane separation process, flocculent precipitation) purification, and collect refined solution, concentrate according to a conventional method again, the dry extract that must loosen, make tablet more according to a conventional method.
Embodiment 3:
1. with the Radix Et Rhizoma Rhei of 10% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 16% Radix Bupleuri, 10% Radix Scutellariae, 8% the Radix Paeoniae Alba, 14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 12% Fructus Aurantii Immaturus (parched), 17% Rhizoma Zingiberis Recens, 13% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. with above-mentioned medicinal liquid with conventional resin adsorption method (or conventional membrane separation process, flocculent precipitation) purification, and collect refined solution, concentrate according to a conventional method again, the dry extract that must loosen, the extract that will loosen is again made capsule according to a conventional method.
Embodiment 4:
1. with the Radix Et Rhizoma Rhei of 9% weight portion,, collect extracting solution with 30～90% (example 30%, 50%, 70%, 90%) ethanol extraction of 5～15 times of amounts (V/W) (5,10,15 times of examples);
2. with 19% Radix Bupleuri, 14% Radix Scutellariae, 12% the Radix Paeoniae Alba, 8% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 10% Fructus Aurantii Immaturus (parched), 16% Rhizoma Zingiberis Recens, 12% Fructus Jujubae seven flavor Chinese medicines, water with 5～15 times of amounts (V/W) (5,10,15 times of examples), heating decocts, get decocting liquid, decocting liquid is filtered, filtrate concentrates, adding ethanol makes content reach 30～80% (examples 30%, 50%, 70%, 80%), standing over night filters, and gets filtrate;
3. with step 1., the extracting solution that 2. obtains, filtrate merge, conventional method reclaims ethanol, medicinal liquid;
4. with above-mentioned medicinal liquid with conventional resin adsorption method (or conventional membrane separation process, flocculent precipitation) purification, and collect refined solution, concentrate according to a conventional method again clear paste, again this clear paste is mixed with oral liquid according to a conventional method.
Claims (9)
1, a kind of big Radix Bupleuri oral formulations is characterized in that: make by containing following materials of weight proportions:
Radix Bupleuri 15～22% Radix Scutellariaes 8～14%
The Radix Paeoniae Alba 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s 8～14%
Fructus Aurantii Immaturus (parched) 8～14% Radix Et Rhizoma Rhei 6～10%
Rhizoma Zingiberis Recens 5～20% Fructus Jujubaes 10～16%.
2, big Radix Bupleuri oral formulations according to claim 1 is characterized in that; Oral formulations is granule or tablet, capsule.
3, big Radix Bupleuri oral formulations according to claim 1, it is characterized in that: oral formulations is an oral liquid.
4, a kind of production method of big Radix Bupleuri oral formulations is characterized in that: comprise the following steps:
1. with the Radix Et Rhizoma Rhei of 6～10% weight portions, use ethanol extraction, collect extracting solution;
2. with 15～22% Radix Bupleuri, 8～14% Radix Scutellariae, 8～14% the Radix Paeoniae Alba, 8～14% Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 8～14% Fructus Aurantii Immaturus (parched), 15～20% Rhizoma Zingiberis Recens, 10～16% Fructus Jujubae seven flavor Chinese medicines, obtain extracting solution with decoction and alcohol sedimentation technique;
3. with step 1., the extracting solution that 2. obtains merges, and reclaims ethanol, obtains medicinal liquid;
4. will produce oral formulations through the 3. medicinal liquid of gained.
5, the production method of big Radix Bupleuri oral formulations according to claim 4, it is characterized in that: the method that 4. step produces oral granular formulation is: medicinal liquid is concentrated into clear paste, and the qinghuo reagent spray drying gets the medicine dried cream powder, again dried cream powder is made granule, promptly get oral granular formulation.
6, the production method of big Radix Bupleuri oral formulations according to claim 4, it is characterized in that: the method that 4. step produces oral tablet or capsule is: with medicinal liquid be further purified, concentrate drying gets dry extract, dry extract made tablet or capsule again.
7, the production method of big Radix Bupleuri oral formulations according to claim 6 is characterized in that: the method for purification is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution.
8, the production method of big Radix Bupleuri oral formulations according to claim 4 is characterized in that: the method that 4. step produces oral liquid is: with medicinal liquid be further purified, concentrate clear paste, again this clear paste is mixed with oral liquid.
9, the production method of big Radix Bupleuri oral formulations according to claim 8 is characterized in that: the method for purification is: medicinal liquid by resin absorption or membrance separation, flocculation sediment, is collected refined solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112711 CN1430996A (en) | 2003-01-15 | 2003-01-15 | Oral prepn. of big bupleurum root and its prodn. methods |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03112711 CN1430996A (en) | 2003-01-15 | 2003-01-15 | Oral prepn. of big bupleurum root and its prodn. methods |
Publications (1)
| Publication Number | Publication Date |
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| CN1430996A true CN1430996A (en) | 2003-07-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03112711 Pending CN1430996A (en) | 2003-01-15 | 2003-01-15 | Oral prepn. of big bupleurum root and its prodn. methods |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425226C (en) * | 2004-02-10 | 2008-10-15 | 湖北丽益医药科技有限公司 | Chinese medicine composition for treating acute cholecystitis and preparing method thereof |
| CN101428049B (en) * | 2008-12-11 | 2011-08-31 | 江苏省中国科学院植物研究所 | Upper respiratory tract infection resistant medicament composition, preparation and uses thereof |
| CN102579730A (en) * | 2012-03-22 | 2012-07-18 | 吉林紫鑫药业股份有限公司 | Medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis |
| CN104815306A (en) * | 2015-05-09 | 2015-08-05 | 高淑贤 | Medicine for treating acute cholecystitis and preparation method thereof |
| CN105250963A (en) * | 2015-11-04 | 2016-01-20 | 安徽益健堂中药饮片科技有限公司 | Traditional Chinese medicine composition for treating cholecystitis and gall-stone |
| CN105267911A (en) * | 2015-01-16 | 2016-01-27 | 王新建 | Traditional Chinese medicine for treating chronic cholecystitis |
-
2003
- 2003-01-15 CN CN 03112711 patent/CN1430996A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100425226C (en) * | 2004-02-10 | 2008-10-15 | 湖北丽益医药科技有限公司 | Chinese medicine composition for treating acute cholecystitis and preparing method thereof |
| CN101428049B (en) * | 2008-12-11 | 2011-08-31 | 江苏省中国科学院植物研究所 | Upper respiratory tract infection resistant medicament composition, preparation and uses thereof |
| CN102579730A (en) * | 2012-03-22 | 2012-07-18 | 吉林紫鑫药业股份有限公司 | Medicine composition for treating acute or chronic cholecystitis and acute or chronic pancreatitis |
| CN102579730B (en) * | 2012-03-22 | 2014-01-08 | 吉林紫鑫药业股份有限公司 | A pharmaceutical composition for treating acute and chronic cholecystitis and acute and chronic pancreatitis |
| CN105267911A (en) * | 2015-01-16 | 2016-01-27 | 王新建 | Traditional Chinese medicine for treating chronic cholecystitis |
| CN104815306A (en) * | 2015-05-09 | 2015-08-05 | 高淑贤 | Medicine for treating acute cholecystitis and preparation method thereof |
| CN105250963A (en) * | 2015-11-04 | 2016-01-20 | 安徽益健堂中药饮片科技有限公司 | Traditional Chinese medicine composition for treating cholecystitis and gall-stone |
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