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CN1415370A - a medicine for stomach pain - Google Patents

a medicine for stomach pain Download PDF

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Publication number
CN1415370A
CN1415370A CN 02146257 CN02146257A CN1415370A CN 1415370 A CN1415370 A CN 1415370A CN 02146257 CN02146257 CN 02146257 CN 02146257 A CN02146257 A CN 02146257A CN 1415370 A CN1415370 A CN 1415370A
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ethanol
pharmaceutical composition
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CN 02146257
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Chinese (zh)
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丰兴波
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Priority to CN 02146257 priority Critical patent/CN1415370A/en
Publication of CN1415370A publication Critical patent/CN1415370A/en
Priority to HK03104238A priority patent/HK1051769A2/en
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Abstract

The invention discloses a medicinal composition for treating stomachache, which is prepared from the following raw material medicaments: 100-150 parts of bupleurum, 100-150 parts of dried orange peel, 100-200 parts of nutgrass galingale rhizome, 100-150 parts of bitter orange, 90-120 parts of corydalis tuber, 60-100 parts of red paeony root, 60-100 parts of evodia rutaecarpa, 60-100 parts of coptis chinensis, 60-100 parts of rhizoma bletillae and 60-100 parts of honey-fried licorice root.

Description

A kind of medicine for the treatment of stomachache
Technical field
The present invention relates to a kind of medicine, particularly relate to a kind of medicine for the treatment of stomachache.
Background technology
Stomachache is common in diseases such as chronic gastritis, duodenitis, peptic ulcer, gastritis, and these diseases are all relevant with helicobacter pylori, and Chinese medicine thinks that these diseases are by gastric qi pent-up, caused by energy stagnation and blood stasis.
Technology contents
The object of the invention is to provide a kind of medicine for the treatment of stomachache and preparation method thereof.
The present invention seeks to be achieved through the following technical solutions:
Radix Bupleuri 100-150 weight portion Pericarpium Citri Reticulatae 100-150 weight portion
Rhizoma Cyperi 100-200 weight portion Fructus Aurantii 100-150 weight portion
Rhizoma Corydalis 90-120 weight portion Radix Paeoniae Rubra 60-100 weight portion
Fructus Evodiae 60-100 weight portion Rhizoma Coptidis 60-100 weight portion
Pseudobulbus Bletillae (Rhizoma Bletillae) 60-100 weight portion Radix Glycyrrhizae Preparata 60-100 weight portion
It is standby that above medical material Rhizoma Bletillae powder is broken into 100 order fine powders, Pericarpium Citri Reticulatae half, Rhizoma Cyperi is ground into coarse powder, doubly measures 70-90% ethanol with 6-10, dipping, slowly percolation is collected percolate, reclaims ethanol, is concentrated into the thick paste shape; Medicinal residues add 7 flavor medical materials such as Radix Bupleuri, decoct with water 2-4 time, decoct 1-2 hour at every turn, add 8-12 times of water gaging, merge decoction liquor, filter, filtrate is concentrated into 80 ℃ of following proportions 1.08, put coldly, add ethanol, make to contain the alcohol amount and reach 50-65%, leave standstill, filter, reclaim ethanol, merge above-mentioned thick paste, drying is made dried cream, crushing screening, add Rhizoma Bletillae powder and second half Pericarpium Citri Reticulatae powder, make clinical acceptable forms, as tablet, pill, oral liquid, capsule, granule etc. Experimental example:
Capsule (the Asia stomach open capsule) main pharmacodynamics of the present invention's preparation
1, the logical antiulcer action of Asia stomach to experimental gastric ulcer
1.1 rats acetic acid calcination gastric ulcer model
Wistar rat fasting 24 hours is freely drunk water.Etherization, the sterile working in the positive split shed of xiphoid-process, gently pulls out stomach.Cut an osculum at stomach, on glandular stomach portion antetheca hole body boundary serosal surface, sticking the area that is soaked with glacial acetic acid is 5 * 5mm 2Circular filter paper.Take off filter paper after 90 seconds, sew up stomach, stomach is sent back to gently, sew up abdominal muscle and skin.Postoperative is normally raised, animal random packet and give relative medicine after 2 days, and gastric infusion is 9 continuously.Behind last administration 2h, put to death, cut open the belly, ligation pylorus and cardia.Get stomach, inject 1% formalin 5ml, stomach is immersed in 1% formalin fixedly 10min from glandular stomach portion.Cut off along greater gastric curvature then, normal saline washes away content, and anatomic microscope is observed the gastric mucosa injury situation and calculated the ulcer area, compares between each group.
The result shows that with the matched group ratio, the gastric ulcer area of the logical large and small dosage group of Asia stomach has reduced 62.9% (P＜0.01) and 41.3% (P＜0.05) respectively.The energy-stagnation stomachache group also has the significance inhibitory action to the formation of gastric ulcer, and the ulcer area has reduced by 45.5% (P＜0.05).
1.2 rat pylorus ligation gastric ulcer model
Wistar rat grouping administration is seen before and is stated.Behind the continuous irrigation stomach 6 days, fasting 72h (can't help water, not banning drugs) under etherization afterwards, opens the abdominal cavity, the ligation pylorus, and water is prohibited in fasting, and disconnected neck is put to death rat behind the 18h.Stomach is got in dissection, and formaldehyde fixed is the same, and 10min tailing edge greater gastric curvature is cut off stomach, measures and calculating ulcer area, carries out statistical analysis with its summation as ulcer index.Experimental result shows that logical heavy dose of group of Asia stomach and small dose group make the gastric ulcer damage index reduce 60.6% (P＜0.05) and 50.8% (P＜0.05) respectively.
1.3 rat indometacin gastric ulcer model
Wistar rat grouping administration is the same.Behind the continuous irrigation stomach 7 days, fasting 36h (can't help water, not banning drugs), 1h after the last administration, lumbar injection 0.5% indometacin 1ml/100g.Behind the 7h animal is all taken off neck and put to death, cut open the belly immediately, behind stomach cardia and pylorus ligation, formaldehyde fixed.10min tailing edge greater gastric curvature is cut off stomach, and it is damaged to examine stomach mucosa, and anatomic microscope is measured the sticking unconcerned damaged length (mm) of stomach down, carries out statistical analysis with its summation as ulcer index.Experimental result shows that stomach logical heavy dose of group in Asia makes ulcer index reduce by 59.3% (P＜0.05), and the energy-stagnation stomachache group makes ulcer index reduce by 71.1% (P＜0.01).
2, mouse small intestine ahead running experiment
Kunming mouse grouping administration is seen before and is stated.Gastric infusion is 5 days continuously, behind the last medicine 15 minutes, irritate stomach and give carbon powder arabic gum suspension 0.1ml/10g, put to death animal after 15 minutes, measurement from the stomach pylorus to ileocecus small intestinal total length and charcoal end the distance of dividing a word with a hyphen at the end of a line in small intestinal, calculate the intestinal propulsion percentage rate as follows.
The result shows that the mouse small intestine propelling rate of the logical large and small dosage group of Asia stomach has increased by 38.9% (P＜0.01) and 18.5% (P＜0.05) than normal control group respectively.
3. the logical influence of Asia stomach to helicobacter pylori
The helicobacter pylori type strain is inoculated 10% calf serum brucella broth, under little oxygen condition, cultivates 3 days for 37 ℃, is diluted to 3 * 10 with physiological saline solution before the test 6CFU/ml concentration bacteria suspension.After medicine ground, being diluted to concentration respectively with normal saline was 50%, 25%, 12.5%, 6.25%, 3.125% medicinal liquid (w/v).Be mixed and made into flat board with culture medium and each medicinal liquid by 9: 1, each dull and stereotyped medicine depth bounds is 3.125～50mg/ml.Get 0.1ml 3 * 10 6The CFU/ml bacteria suspension is inoculated in beautiful fat surface, makes its even coating, and little oxygen condition is cultivated 72h, observes minimal inhibitory concentration (MIC).The result shows that Asia stomach open capsule medicated powder has the obvious suppression effect to the type strain helicobacter pylori.Asia stomach open capsule medicated powder concentration suppresses helicobacter pylori fully when 12.5mg/ml is above.
4. the Asia stomach is logical to gastric juice, pepsic influence
Wistar rat grouping administration is seen before and is stated, gastric infusion after 5 days continuously, fasting 24h (can't help water, not banning drugs).1h after the last administration uses etherization, opens one in xiphoid-process lower edge hunter's line and is about the 2.5cm otch, carefully mentions stomach, pricks with toe-in at pylorus and duodenum joint portion.Postoperative is sewed up and is sent back in the cage, and water is prohibited in fasting, puts to death rat behind the 5h.Collect gastric juice, the centrifugal 10min of 3000 commentaries on classics/min, record supernatant liquid measure is the gastric juice amount, and measures total acidity, total acid output and pepsin activity.
Gastric acidity determination: get gastric juice 2ml at previous night and put in the small beaker, add start going to a nursery Fo Shi liquid and 2 of phenolphthalein indicators and (be cherry red when containing free acid, be not yellow when having the acid of trip glass), with slowly titration of NaOH 0.02mol/L (using burette), constantly shake simultaneously, it is yellow to drip the extremely red appearance that disappears, and continuation till blush was not moved back in 2 seconds, is the total acidity titration end-point with the titration of NaOH solution.The milliliter number of record NaOH that titration consumes.
Milliliter number * 10 of total gastric acidity NaOH that (mmol/L)=titration consumed.
The gastric juice amount of total acid output (μ mol/h)=total gastric acid * per hour.
Pepsin is measured: adopt the Mett capillary tube method.It is long that the glass capillary that internal diameter 1～2mm is well-balanced is cut into 10cm, cleans and dry.Get Ovum Gallus domesticus album and fully beat even back and use filtered through gauze, utilize siphonage that the capillary pipe of coming off duty is filled Ovum Gallus domesticus album (in noting managing bubble must not be arranged).Be placed on then in 85 ℃ of hot water and make protein coagulation, standby in the storage refrigerator.Get gastric juice 1mol and put into the 50ml beaker, add the 0.05mol/L hydrochloric acid solution, put 2 of protein pipe into.Filled in bottleneck, temperature is incubated 24h in 37 ℃ of calorstats.Take out protein pipe, measure the length (mm) of protein pipe two ends transparent part, ask its meansigma methods with the value of four ends.Every ml pepsin activity unit=meansigma methods 2* 16.
The result shows, the logical effect with minimizing rat stomach liquid measure and total acid output of Asia stomach.
5. experiment conclusion
Damage has significant protective effect to the logical Chinese medicine powder gastric infusion of Asia stomach to the kinds of experiments gastric ulcer, can reduce rat stomach liquid measure and total acid output.The mouse small intestine ahead running is had potentiation, lumbar injection acetic acid induced mice pain reaction is had inhibitory action.The Asia stomach is logical to have significant inhibitory effect to the helicobacter pylori type strain.
Embodiment:
Radix Bupleuri 137g Pericarpium Citri Reticulatae 137g Rhizoma Cyperi 164g Fructus Aurantii 137g
Rhizoma Corydalis 110g Radix Paeoniae Rubra 82g Fructus Evodiae 82g Rhizoma Coptidis 82g
Pseudobulbus Bletillae (Rhizoma Bletillae) 82g Radix Glycyrrhizae Preparata 82g
It is standby that above medical material Rhizoma Bletillae powder is broken into 100 order fine powders, Pericarpium Citri Reticulatae half, Rhizoma Cyperi is ground into coarse powder, according to percolation under the fluid extract item,, flood after 24 hours with 8 times of amount 80% alcohol, percolation slowly, the collection percolate, recovery ethanol is concentrated into the thick paste shape; Medicinal residues add 7 flavor medical materials such as Radix Bupleuri, decoct with water secondary, and 12 times of water gagings decocted 2 hours for the first time,, 10 times of water gagings decocted 1 hour for the second time, and decoction liquor, filter, filtrate is concentrated into proportion 1.08 (80 ℃), puts coldly, adds ethanol, make and contain alcohol amount and reach 60%, left standstill 24 hours, and filtered, reclaim ethanol, merge above-mentioned thick paste, drying is made dried cream, and crushing screening adds Rhizoma Bletillae powder and second half Pericarpium Citri Reticulatae powder (processing of 40 mesh sieves) and adjuvant mix homogeneously, adorn capsule No. one, make 1000, the heavily about 0.3g of capsule, promptly.

Claims (9)

1、一种治疗胃痛的药物组合物，其特征在于该药物是由如下原料药制成的：1. A pharmaceutical composition for treating stomach pain, characterized in that the medicine is made from the following raw materials: 柴  胡  100-150重量份      陈  皮  100-150重量份Bupleurum 100-150 parts by weight Chen Pi 100-150 parts by weight 香  附  100-200重量份      枳  壳  100-150重量份Cyperus 100-200 parts by weight Aurantium aurantium 100-150 parts by weight 延胡索  90-120重量份       赤  芍  60-100重量份Corydalis 90-120 parts by weight Radix Paeoniae Alba 60-100 parts by weight 吴茱萸  60-100重量份       黄  连  60-100重量份Evodia 60-100 parts by weight Coptis chinensis 60-100 parts by weight 白  及  60-100重量份       炙甘草  60-100重量份White and 60-100 parts by weight Roasted licorice 60-100 parts by weight 2、如权利要求1所述的药物组合物，其特征在于该药物是由如下原料药制成的：2. The pharmaceutical composition according to claim 1, characterized in that the drug is made from the following raw materials: 柴  胡  137重量份    陈  皮  137重量份Bupleurum 137 parts by weight Chen Pi 137 parts by weight 香  附  164重量份    枳  壳  137重量份Cyperus 164 parts by weight, Citrus aurantium husk 137 parts by weight 延胡索  110重量份    赤  芍  82重量份Corydalis 110 parts by weight Radix Paeoniae Alba 82 parts by weight 吴茱萸  82重量份     黄  连  82重量份Evodia 82 parts by weight Coptis chinensis 82 parts by weight 白  及  82重量份     炙甘草  82重量份White and 82 parts by weight Zhilicorice 82 parts by weight 3、如权利要求1-2所述的药物组合物的制备方法，其特征在于该方法为：3. The preparation method of the pharmaceutical composition according to claims 1-2, characterized in that the method is: 药材白及粉碎成100目细粉备用，陈皮一半、香附粉碎成粗粉，用6-10倍量70-90％乙醇，浸渍，缓缓渗漉，收集渗漉液，回收乙醇，浓缩至稠膏状；药渣加入柴胡等7味药材，加水煎煮2-4次，每次煎煮1-2小时，加8-12倍量水，合并煎煮液，滤过，滤液浓缩至80℃下比重1.08，放冷，加入乙醇，使含醇量达50-65％，静置，滤过，回收乙醇，合并上述稠膏，干燥制成干膏，粉碎过筛，加入白及粉和另一半陈皮粉，制成临床可接受的剂型。The medicinal material white and crushed into 100-mesh fine powder for later use, half of tangerine peel and Cyperus cyperi were crushed into coarse powder, soaked with 70-90% ethanol in 6-10 times the amount, slowly percolated, collected percolated liquid, recovered ethanol, concentrated to Thick paste; add bupleurum and other 7 herbs to the dregs, add water to decoct 2-4 times, decoct for 1-2 hours each time, add 8-12 times the amount of water, combine the decoction liquid, filter, and concentrate the filtrate to The specific gravity is 1.08 at 80°C, let it cool, add ethanol to make the alcohol content reach 50-65%, let stand, filter, recover ethanol, combine the above thick paste, dry to make a dry paste, crush and sieve, add white and powder And the other half of tangerine peel powder to make a clinically acceptable dosage form. 4、如权利要求3所述的制备方法，其特征在于该方法为：4. The preparation method according to claim 3, characterized in that the method is: 以上药材白及粉碎成100目细粉备用，陈皮一半、香附粉碎成粗粉，用8倍量80％乙醇，浸渍24小时后，缓缓渗漉，收集渗漉液，回收乙醇，浓缩至稠膏状；药渣加入柴胡等7味药材，加水煎煮二次，第一次煎煮2小时，加12倍量水，第二次煎煮1小时，加10倍量水，合并煎煮液，滤过，滤液浓缩至比重1.08，放冷，加入乙醇，使含醇量达60％，静置24小时，滤过，回收乙醇，合并上述稠膏，干燥制成干膏，粉碎过筛，加入白及粉和另一半陈皮粉与辅料混合均匀，装胶囊，即得。The above medicinal materials are white and crushed into 100 mesh fine powder for later use, half of the tangerine peel and Cyperus cyperi are crushed into coarse powder, soaked in 80% ethanol with 8 times the amount, after soaking for 24 hours, slowly percolate, collect the percolation liquid, recycle the ethanol, and concentrate to Thick paste; add bupleurum and other 7 medicinal materials to the dregs, add water to decoct twice, decoct for 2 hours for the first time, add 12 times the amount of water, decoct for 1 hour for the second time, add 10 times the amount of water, and decoct together Boil the liquid, filter, concentrate the filtrate to a specific gravity of 1.08, let it cool, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, recover the ethanol, combine the above thick paste, dry it to make a dry paste, and crush it Sieve, add Baiji powder and the other half of tangerine peel powder and auxiliary materials, mix evenly, pack into capsules, and you get it. 5、如权利要求1-2所述的药物组合物在制备治疗胃溃疡的药物中的应用。5. The use of the pharmaceutical composition according to claims 1-2 in the preparation of medicine for treating gastric ulcer. 6、如权利要求1-2所述的药物组合物在制备减少胃液量和总酸排出量的药物中的应用。6. The use of the pharmaceutical composition according to claims 1-2 in the preparation of medicines for reducing gastric juice volume and total acid excretion. 7、如权利要求1-2所述的药物组合物在制备具有增强小肠推进运动的药物中的应用。7. The use of the pharmaceutical composition according to claims 1-2 in the preparation of medicaments capable of enhancing the propulsive movement of the small intestine. 8、如权利要求1-2所述的药物组合物在制备具有抑制因酸所致疼痛反应的药物中的应用。8. The use of the pharmaceutical composition according to claims 1-2 in the preparation of medicines capable of inhibiting the pain response caused by acid. 9、如权利要求1-2所述的药物组合物在制备具有抑制幽门螺旋菌的药物中的应用。9. The use of the pharmaceutical composition according to claims 1-2 in the preparation of medicines capable of inhibiting Helicobacter pylori.
CN 02146257 2002-10-17 2002-10-17 a medicine for stomach pain Pending CN1415370A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN 02146257 CN1415370A (en) 2002-10-17 2002-10-17 a medicine for stomach pain
HK03104238A HK1051769A2 (en) 2002-10-17 2003-06-13 A chinese patent drug for treating stomachache

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Application Number Priority Date Filing Date Title
CN 02146257 CN1415370A (en) 2002-10-17 2002-10-17 a medicine for stomach pain

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1307972C (en) * 2005-11-02 2007-04-04 那丽茹 Stomachache treating Chinese medicine
CN100374145C (en) * 2006-04-28 2008-03-12 四川宝光药业股份有限公司 A medicine for treating gastric disease and preparation method thereof
CN100391527C (en) * 2005-05-24 2008-06-04 马希文 Medicine for treating gastrodynia disease
CN103239538A (en) * 2013-01-15 2013-08-14 湖南新汇制药股份有限公司 Helicobacter pylori-resisting pharmaceutical composition for stomach illness
CN107997166A (en) * 2016-11-01 2018-05-08 北京振东光明药物研究院有限公司 A kind of health products and preparation method for improving sleep, relieving fatigue strengthen immunity

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100391527C (en) * 2005-05-24 2008-06-04 马希文 Medicine for treating gastrodynia disease
CN1307972C (en) * 2005-11-02 2007-04-04 那丽茹 Stomachache treating Chinese medicine
CN100374145C (en) * 2006-04-28 2008-03-12 四川宝光药业股份有限公司 A medicine for treating gastric disease and preparation method thereof
CN103239538A (en) * 2013-01-15 2013-08-14 湖南新汇制药股份有限公司 Helicobacter pylori-resisting pharmaceutical composition for stomach illness
CN103239538B (en) * 2013-01-15 2015-07-29 湖南新汇制药股份有限公司 A kind of gastropathy drug composition of anti-helicobacter pylori
CN107997166A (en) * 2016-11-01 2018-05-08 北京振东光明药物研究院有限公司 A kind of health products and preparation method for improving sleep, relieving fatigue strengthen immunity

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