CN1314431C - Traditional Chinese medicine for treeting gonarthrosis - Google Patents

Abstract

The present invention relates to traditional Chinese medicine for treating gonarthrosis. The present invention is prepared from raw materials of radix saposhinkoviae, olibanum, myrrh, atractylodes rhizome, radix achyranthis bidentatae, nuxvomica, ephedra, angelica, kusnezoff monkshood root, williams elder twig, wild grape vine, acanthopanax, rehmannia root, astragalus root, deerhorn glue, polygonatum and liquorice. The present invention has a production method that the medical materials are simultaneously ground into fine powder, sieved and uniformly mixed, and honeyed pills are obtained. The traditional Chinese medicine of the present invention has the special effect of nourishing the blood, protecting the knee, promoting the blood circulation, expelling wind, eliminating swelling, relieve inflammation, eliminating wind-damp and alleviating pain, and can be widely used for treating diseases such as rheumarthritis, traumatic arthritis, trauma knee joint tumid, articular dropsy, empyema knee joint hyperplasy, knee joint crack, knee joint coldness, knee joint sour pain, sciatica, etc.

Description

A kind of Chinese medicine for the treatment of gonarthrosis

Technical field: the present invention relates to Chinese medicine, particularly treat the Chinese medicine of gonarthrosis.

Background technology: the Western medicine for the treatment of gonarthrosis at present generally all has side effect, and the Chinese medicine of treatment gonarthrosis of a great variety but cure the disease effect not significantly, cure the symptoms, not the disease, stay sequela after the patient takes.

The content of invention: overcome the deficiency that prior art exists, propose a kind of Chinese medicine of evident in efficacy, the treatment gonarthrosis that do not recur after more.This Chinese medicine is made by the following weight proportion raw material: Radix Saposhnikoviae 13-17 part, Olibanum 8-12 part, Myrrha 8-12 part, Rhizoma Atractylodis 10-14 part, Radix Achyranthis Bidentatae 13-17 part, Semen Strychni 18-22 part, Herba Ephedrae 10-14, Radix Angelicae Sinensis 8-12 part, North Radix Aconiti Kusnezoffii 3-7 part, Ramulus Sambuci Williamsii 23-37 part, Caulis Vitis Romanetii 10-14 part, Radix Et Caulis Acanthopanacis Senticosi 8-12 part, Radix Rehmanniae-45, astragalus 13-17 part, Colla cornus cervi 13-17 part, Rhizoma Polygonati Odorati 13-17 part, Radix Glycyrrhizae 13-17 part.Its production method is: each flavor medicine is ground to smalls together, crosses decorations, mixes the even honeyed pill of promptly making.The present invention is because to contain its composition of Radix Saposhnikoviae be volatile oil, mannitol, bitterness glycoside, and arthritis is had the effect of analgesic anti-inflammatory analgesic and can rheumatism antibiotic; Colla cornus cervi contains glue, contains albumen, calcic therefore can qi-supplementing, blood-engendering be replenished the calcium, hemapodium and marrow is given birth to, marrow is given birth to and bone is long; It is best that Olibanum, Myrrha contain composition analgesias such as volatile oil, resin, natural gum, cinnamic aldehyde, limonene; Rhizoma Atractylodis contain atractylone, volatile oil, vitamin A, B etc. can protect hepatic injury, anti-inflammation analgesia; Therefore can increase hematopoietic function increase immunity owing to contain the Radix Astragali, Radix Ginseng; Because Rhizoma Polygonati Odorati contains fragrant solomonseal rhizome polyoses, convallarin, vitamin A etc. and can protect heart; Radix Rehmanniae contains polysaccharide has the protection liver heart to nourish blood except that rheumatism, anti-inflammation detumescence; But Herba Ephedrae contains multiple alkaloid is equipped with Olibanum, Myrrha, Radix Rehmanniae pain relieving analgesia; Semen Strychni contains strychnine, strychnine alkali, has the effect of nervus motorius sedation-analgesia; But Ramulus Sambuci Williamsii synthetism Soothe tendons and activating-blood anodyne; But Caulis Vitis Romanetii contains polysaccharide treating the liver disease, heart disease, also can treat sciatica, rheumatalgia, traumatic injury; Radix Achyranthis Bidentatae draws vim and vigour and goes downwards to knee joint, anti-inflammatory analgetic, strong muscles and bones; The result of above-mentioned every medicine comprehensive function makes Chinese medicine of the present invention have the knee cap that nourishes blood, promoting blood circulation by removing wind, detumescence antiinflammatory, removes the specially good effect of rheumatic arthralgia.

The specific embodiment: get Radix Saposhnikoviae 13g, Olibanum 8g, Myrrha 8g, Rhizoma Atractylodis 10g, Radix Achyranthis Bidentatae 13g, Semen Strychni 18g, Herba Ephedrae 18g, Radix Angelicae Sinensis 8g, northern careless bird 3g, Ramulus Sambuci Williamsii 23g, Caulis Vitis Romanetii 10g, Radix Et Caulis Acanthopanacis Senticosi 8g, Radix Rehmanniae 35g, Radix Astragali 13g, Colla cornus cervi 13g, Rhizoma Polygonati Odorati 13g, Radix Glycyrrhizae 13g.

Its production method is: each flavor medicine is ground to smalls together, sieves, mixes to spare and promptly make honeyed pill.Every ball weighs 6 grams.

Second embodiment of wood invention: get Radix Saposhnikoviae 17g, Olibanum 12g, Myrrha 12g, Rhizoma Atractylodis 14g, Radix Achyranthis Bidentatae 17g, Semen Strychni 22g, Herba Ephedrae 14g, Radix Angelicae Sinensis 12g, northern careless bird 7g, Ramulus Sambuci Williamsii 27g, Caulis Vitis Romanetii 14g, Radix Et Caulis Acanthopanacis Senticosi 12g, Radix Rehmanniae 45g, Radix Astragali 17g, Colla cornus cervi 17g, Rhizoma Polygonati Odorati 17g, Radix Glycyrrhizae 17g.Its production method is: each flavor medicine is ground to smalls together, sieves, mixes to spare and promptly make honeyed pill.Every ball weighs 6 grams.

The usage of this medicine and consumption: one after each meal sooner or later, a twice-daily, each 1 ball of adult, children's reduces by half, seriously ill person every day three times.

In order to estimate the clinical medicine safety of Chinese medicine of the present invention, it has been carried out toxicity test research, be reported as follows:

1. be subjected to test product: a kind of Chinese medicine every day for the treatment of gonarthrosis 2 times, each 6 grams.

2. experimental animal: the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.

3. the preparation of dosage and test drug: get a kind of Chinese medicine for the treatment of gonarthrosis 18 grams, put and add the 1000ml distilled water in the mortar and be uniformly dispersed, making concentration is 24% solution.Administering mode is a gastric infusion.

The mensuration of median lethal dose(LD 50)

Get 9 of mices, divide three groups, but fail to find out the dosage of 100% animal dead.

Select 50 of the healthy mices of body weight 20 ± 2g for use, male and female half and half are divided into five groups at random, an oral administration gavage administration, and dosage is by geometric progression, and maximum dose level calculates with the maximum volume that can accept.Observed 7 days none death as a result after the administration.

Mtd test

Select 20 of healthy mices, male and female half and half, normally raise 1 after, administration is 3 times in 24 hours, 5 hours blanking times, total administration volume 120ml/kg observed 7 continuously, did not see untoward reaction and death condition, can think the oral avirulence of this medicine.

The maximum tolerated dose multiple is calculated as follows:

$=\frac{0.8\·3\·24\%}{20}\×\frac{60000}{6\×3\×0.4}$

Calculate if obey 18 grams every day by the adult, the result is 240 times of normal clinical dosage, illustrates that a kind of Chinese medicine for the treatment of gonarthrosis has safety.

A kind of Chinese medicine clinical summary for the treatment of gonarthrosis

One group to the statistics in the gonarthrosis clinical observation material.This organizes 5% case for observing the patient of treatment.Man's 43 examples wherein, woman's 16 examples, age 40-50 year 10 examples, 51-60 year 30 examples, 19 examples more than 61 years old, rheumatic arthritis 9 examples, traumatic arthritis 6 examples, wound arthroncus of knee joints, hydrarthrosis, empyema knee hyperplasia, knee joint crack, knee joint are emitted cold wind, knee joint 33 examples of aching, sciatica 3 examples.Wherein Therapeutic Method is the patient to be divided into two groups at random, and 39 examples are organized in treatment, obeys capsule of the present invention, every day three times, and each 1 ball, 60 days is a course of treatment.Matched group 20 examples are taken other medicine, and 60 days is a course of treatment, withdraws other medicines before the administration, all do inspection before and after the treatment, and the result shows that the treatment group effective percentage of taking Chinese medicine of the present invention is 98%, and matched group does not have positive effect.

Claims (2)

1, a kind of Chinese medicine of treatment gonarthrosis, it is characterized in that: this Chinese medicine is made up of following raw materials by weight proportions: Radix Saposhnikoviae 13-17 part, Olibanum 8-12 part, Myrrha 8-12 part, Rhizoma Atractylodis 10-14 part, Radix Achyranthis Bidentatae 13-17 part, Semen Strychni 18-22 part, Herba Ephedrae 10-14, Radix Angelicae Sinensis 8-12 part, North Radix Aconiti Kusnezoffii 3-7 part, Ramulus Sambuci Williamsii 23-37 part, Caulis Vitis Romanetii 10-14 part, Radix Et Caulis Acanthopanacis Senticosi 8-12 part, Radix Rehmanniae-45, Radix Astragali 13-17 part, Colla cornus cervi 13-17 part, Rhizoma Polygonati Odorati 13-17 part, Radix Glycyrrhizae 13-17 part.

2, a kind of Chinese medicine of gonarthrosis as claimed in claim 1 is characterized in that: its production method is that each flavor medicine is ground to smalls together, sieves, mixes to spare and make honeyed pill.