CN1308015C - Chinese medicine for curing toothache - Google Patents
Chinese medicine for curing toothache Download PDFInfo
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- CN1308015C CN1308015C CNB031108423A CN03110842A CN1308015C CN 1308015 C CN1308015 C CN 1308015C CN B031108423 A CNB031108423 A CN B031108423A CN 03110842 A CN03110842 A CN 03110842A CN 1308015 C CN1308015 C CN 1308015C
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- energizer
- chinese medicine
- toothache
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 208000004371 toothache Diseases 0.000 title claims abstract description 15
- 244000246386 Mentha pulegium Species 0.000 claims description 5
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 5
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 5
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 5
- 235000001050 hortel pimenta Nutrition 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 230000036592 analgesia Effects 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 241000758794 Asarum Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 241001092090 Pittosporum Species 0.000 abstract 1
- 235000002226 Ranunculus ficaria Nutrition 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 241000293861 Scrophularia nodosa Species 0.000 abstract 1
- 206010039897 Sedation Diseases 0.000 abstract 1
- 208000010641 Tooth disease Diseases 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 230000036280 sedation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 231100000111 LD50 Toxicity 0.000 description 2
- 201000004328 Pulpitis Diseases 0.000 description 2
- 206010037464 Pulpitis dental Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000001143 Periodontal Abscess Diseases 0.000 description 1
- 206010044016 Tooth abscess Diseases 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229940071462 oralone Drugs 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 238000005554 pickling Methods 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a Chinese medicine for treating toothache, which comprises the following components of the portions in the proportion by weight: 15 to 25 portions of rhizoma cimicifugae, 25 to 35 portions of gypsum, 10 to 20 portions of liquorice, 10 to 20 portions of cortex moutan, 15 to 25 portions of coptis, 15 to 25 portions of rhubarb, 10 to 20 portions of mint stem, 10 to 20 portions of asarum herb, 15 to 25 portions of kakuda figwort roots, and 10 to 20 portions of glabrousleaf pittosporum. The Chinese medicine of the present invention has good functions of sedation, analgesia, blood nourishment and ache alleviation, and can eliminate inflammation, detoxicate and broad-spectrum resist bacilli. Pungent warm, divergence and ache alleviation are performed on the upper energizer, cool is dispelled to the middle energizer, bitter cold is lowered to the lower energizer, the upper energizer, the middle energizer and the lower energizer are through adjusted, and fire is abreacted so that toothache can be cured. The present invention can be widely used for treating various tooth diseases.
Description
Technical field: the present invention relates to Chinese medicine, particularly the sick Chinese medicine of treatment toothache.
Background technology: the sick Western medicine curative effect of treatment toothache at present is bad and side effect is generally all arranged, and the sick Shen pharmacopoeia class of treatment toothache is various, but curative effect is slow, the effect of curing the disease is very not remarkable.
The content of invention: overcome the deficiency that prior art exists, it is fast and can effect a radical cure the Chinese medicine of the various toothache that periodontitis, toothache, periodontal abscess, gingivitis, pulpitis etc. cause to propose a kind of curative effect.This Chinese medicine comprises following raw material: Rhizoma Cimicifugae, Gypsum Fibrosum, Radix Glycyrrhizae, unpeeled CORTEX MOUTAN, Rhizoma Coptidis, Radix Et Rhizoma Rhei, peppermint stem, Herba Asari, Radix Scrophulariae, Semen Pittospori Glabrati, the weight ratio umber of its each raw material is: Rhizoma Cimicifugae 15-25 part, Gypsum Fibrosum 25-35 part, Radix Glycyrrhizae 10--20 part, unpeeled CORTEX MOUTAN 10-20 part, Rhizoma Coptidis 15-25 part, Radix Et Rhizoma Rhei 15-25 part, peppermint stem 10-20 part, Herba Asari 10-20 part, Radix Scrophulariae 15-25 part, Semen Pittospori Glabrati 10--20 part.Its production method is: pulverizing after above-mentioned crude drug is mixed, sealing are finished medicines.Therefore Chinese medicine of the present invention have good calmness owing to contain peppermint stem, analgesic activity, the Radix Angelicae Sinensis analgesic effect of nourishing blood, owing to contain Semen Pittospori Glabrati, Rhizoma Coptidis, but Radix Et Rhizoma Rhei is the eliminating inflammation and expelling toxin broad-spectrum antiseptic therefore, unpeeled CORTEX MOUTAN can be antibiotic analgesic, analgesia, the strong compatibility of the scorching effect of a heatable brick bed can increase the power of antiinflammatory antipyretic-antalgic with Radix Scrophulariae, the Gypsum Fibrosum clearing stomach is analgesic kind descending, Rhizoma Cimicifugae is cool in nature and rise and to be good at, make and reach on the efficacy of a drug in tooth portion, the gentle detoxifcation of Radix Glycyrrhizae, concoct all medicines, Radix Glycyrrhizae has the effect of corticoid sample simultaneously, can separate various poison, and the alleviation gastrointestinal convulsion is arranged, can rise and to fall, with the medicine of a cold nature, the cathartic compatibility has the mediation property of medicine, the performance drug effect makes prescription of the present invention hot cool, Xin Wen disperses pain relieving in last, cold separate in, bitter cold is fallen in following, and the upper, middle and lower three warmers are logical to be transferred, fire goes out to have the road, thereby various odontopathy can heal.
The specific embodiment: get Rhizoma Cimicifugae 20g, Gypsum Fibrosum 30g, Radix Glycyrrhizae 15g, unpeeled CORTEX MOUTAN 15g, Rhizoma Coptidis 20g, Radix Et Rhizoma Rhei 20g, peppermint stem 15g, Herba Asari 15g, Radix Scrophulariae 20g, Semen Pittospori Glabrati 15g.Its production method is: pulverizing after above-mentioned ten crude drugs are mixed, sealing are finished medicines.
The usage of this medicine and consumption: 314 times on the oral one, each 10 grams; The last white pickling wine of external Nidus Vespae, the consumption of each Nidus Vespae is the 0.3-0.5 gram, is coated on the tooth of pain with a little, tells after 3-5 minute, Nidus Vespae has the effect of attacking of order wind counteracting toxic substances, reducing swelling and alleviating pain, takes back diet five sufferings, raw and cold greasy.
In order to estimate the clinical medicine safety of Chinese medicine of the present invention, it has been carried out toxicity test research, be reported as follows:
1. be subjected to test product: a kind of Chinese medicine every day for the treatment of toothache 4 times, each 10 grams.
2. experimental animal: the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.
3. the preparation of dosage and test drug: get a kind of Chinese medicine for the treatment of toothache 40 grams, put and add the 100.0ml distilled water in the mortar and be uniformly dispersed, making concentration is 24% solution.Administering mode is a gastric infusion
One, the mensuration of median lethal dose(LD 50)
Get 9 of mices, divide three groups, but fail to find out the dosage of 100% animal dead.Select 50 of the healthy mices of body weight 20 ± 2g for use, male and female half and half are divided into five groups at random, an oral administration gavage administration, and dosage is by geometric progression, and maximum dose level calculates with the maximum volume that can accept.Observed 7 days none death as a result after the administration.
Two, mtd test
Select 20 of healthy mices, male and female half and half, normally raise 1 after, administration is 4 times in 24 hours, 5 hours blanking times, total administration volume 120ml/kg observed 7 continuously, did not see untoward reaction and death condition, can think the oral avirulence of this medicine.
The maximum tolerated dose multiple is calculated as follows:
Calculate if obey 40 grams every day by the adult, the result is 240 times of normal clinical dosage, illustrates that a kind of Chinese medicine for the treatment of toothache has safety.
A kind of Chinese medicine clinical summary for the treatment of toothache
One group to the statistics in the odontopathy clinical observation material.
This organizes 5% case for observing the patient of treatment.Man's 43 examples wherein, women 16 examples, age 40-50 year 10 examples, 51-60 year 30 examples, 19 examples more than 61 years old, with periodontitis 9 examples, gingivitis 6 examples, toothache, pulpitis 33 examples, dense swollen 3 examples of periodontal.Wherein Therapeutic Method is the patient to be divided into two groups at random, and 39 examples are organized in treatment, obeys capsule of the present invention, four times a day, and each 10 grams, 60 days is a course of treatment.Matched group 20 examples are taken other medicine, and 60 days is a course of treatment, withdraws other medicines before the administration, all do inspection before and after the treatment, and the result shows that the treatment group effective percentage of taking Chinese medicine of the present invention is 98%, and matched group does not have obvious effects.
Claims (1)
1, a kind of Chinese medicine for the treatment of toothache is characterized in that: be made up of following components by part by weight: Rhizoma Cimicifugae 15-25 part, Gypsum Fibrosum 25-35 part, Radix Glycyrrhizae 10-20 part, unpeeled CORTEX MOUTAN 10-20 part, Rhizoma Coptidis 15-25 part, Radix Et Rhizoma Rhei 15-25 part, peppermint stem 10-20 part, Herba Asari 10-20 part, Radix Scrophulariae 15-25 part, Semen Pittospori Glabrati 10-20 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031108423A CN1308015C (en) | 2003-01-09 | 2003-01-09 | Chinese medicine for curing toothache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031108423A CN1308015C (en) | 2003-01-09 | 2003-01-09 | Chinese medicine for curing toothache |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1454622A CN1454622A (en) | 2003-11-12 |
| CN1308015C true CN1308015C (en) | 2007-04-04 |
Family
ID=29259919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031108423A Expired - Fee Related CN1308015C (en) | 2003-01-09 | 2003-01-09 | Chinese medicine for curing toothache |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1308015C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304029C (en) * | 2005-03-31 | 2007-03-14 | 徐卫国 | Medicine for treating toothache |
| CN100355432C (en) * | 2005-12-07 | 2007-12-19 | 房丽华 | Chinese and western compounded drug for treating alveolysis and its preparing method |
| CN101244148B (en) * | 2008-03-20 | 2011-04-06 | 张仙峰 | Toothache treating medicine |
| CN103446333A (en) * | 2013-08-01 | 2013-12-18 | 孙海德 | Medicament for preventing and treating odontia |
| CN104623483A (en) * | 2015-03-04 | 2015-05-20 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine decoction for treating periodontitis and preparation method of traditional Chinese medicine decoction |
| CN104758459A (en) * | 2015-04-24 | 2015-07-08 | 王红垒 | Traditional Chinese medicine for treating gingivitis |
| CN105267659A (en) * | 2015-10-30 | 2016-01-27 | 陶新田 | Medicine powder for treating intense stomach fire type odontoseisis |
| CN105412558A (en) * | 2015-11-25 | 2016-03-23 | 禤燕华 | Traditional Chinese medicine composition for treating odontalgia and preparing method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082415A (en) * | 1993-02-01 | 1994-02-23 | 杨清林 | Forced toothache powder |
| CN1306851A (en) * | 2000-01-28 | 2001-08-08 | 傅红喜 | Chinese medicine preparation for treating toothache |
-
2003
- 2003-01-09 CN CNB031108423A patent/CN1308015C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1082415A (en) * | 1993-02-01 | 1994-02-23 | 杨清林 | Forced toothache powder |
| CN1306851A (en) * | 2000-01-28 | 2001-08-08 | 傅红喜 | Chinese medicine preparation for treating toothache |
Non-Patent Citations (1)
| Title |
|---|
| 中西医结合治疗牙周炎120例 姚征宇，浙江中西医结合杂志，第10卷第11期 2000 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1454622A (en) | 2003-11-12 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070404 Termination date: 20140109 |