CN1307974C - Process for preparing formulation containing infinitesimal medicine - Google Patents
Process for preparing formulation containing infinitesimal medicine Download PDFInfo
- Publication number
- CN1307974C CN1307974C CNB2004100536087A CN200410053608A CN1307974C CN 1307974 C CN1307974 C CN 1307974C CN B2004100536087 A CNB2004100536087 A CN B2004100536087A CN 200410053608 A CN200410053608 A CN 200410053608A CN 1307974 C CN1307974 C CN 1307974C
- Authority
- CN
- China
- Prior art keywords
- temperature
- starch
- slurry
- medicine
- icing sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 21
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000000203 mixture Substances 0.000 title description 3
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 229920002472 Starch Polymers 0.000 claims description 29
- 235000019698 starch Nutrition 0.000 claims description 26
- 239000008107 starch Substances 0.000 claims description 26
- 239000002002 slurry Substances 0.000 claims description 24
- 239000007921 spray Substances 0.000 claims description 19
- 239000008187 granular material Substances 0.000 claims description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 13
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 13
- 238000005516 engineering process Methods 0.000 claims description 13
- 229960002568 ethinylestradiol Drugs 0.000 claims description 13
- 229920001353 Dextrin Polymers 0.000 claims description 12
- 239000004375 Dextrin Substances 0.000 claims description 12
- 235000019425 dextrin Nutrition 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000005469 granulation Methods 0.000 claims description 9
- 230000003179 granulation Effects 0.000 claims description 9
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 230000001476 alcoholic effect Effects 0.000 claims description 4
- 238000000889 atomisation Methods 0.000 claims description 4
- 238000010009 beating Methods 0.000 claims description 4
- 235000019890 Amylum Nutrition 0.000 claims description 3
- 238000010410 dusting Methods 0.000 claims description 3
- 239000006187 pill Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 description 26
- 239000003795 chemical substances by application Substances 0.000 description 15
- 239000002904 solvent Substances 0.000 description 7
- 229920000881 Modified starch Polymers 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000005070 sampling Methods 0.000 description 3
- 238000005550 wet granulation Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 241000209051 Saccharum Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 description 1
- 229960003843 cyproterone Drugs 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a process for producing preparation containing infinitesimal medicine, which belongs to the technical field of medicinal preparation. The present invention can make the grain diameter of the main medicament be controlled at a minimum limit under the condition of extreme trace quantity of from 2.000 to 0.005mg/pill, the main medicament is uniformly distributed. The present invention can be used for preparing the preparation containing infinitesimal medicine.
Description
Technical field
The invention belongs to technical field of medicine.Be specifically related to contain the preparation production technique of denier medicine.
Background technology
Granulating process principal agent in tablet manufacturing exists wet granulation and dry granulation dual mode at present, and is comparatively extensive with the wet granulation range of application especially.Wherein wet granulation can be divided into: sieve granulation, fluidized-bed spray granulation, rotation granulation and wet-mixed of soft material granulated.Fluidized-bed spray granulation method wherein, the powder of the raw material that is about to be used to granulate places in the fluidising chamber, and the outside air heating enters fluidising chamber through the bottom screen cloth of fluidising chamber makes the pastille powder be in fluidized state.Binder solution is imported fluidising chamber and be sprayed into little droplet, powder is wetted and be agglomerated into granule, and continuing fluidized drying has suitable water content in granule, promptly.
For effective ingredient in the product is the part of principal agent, and pharmacopeia is limited its labelled amount, and especially the product for drug content≤10mg has also increased uniformity item, to guarantee the monolithic content of dispersion of low dose of product.And when the drug content of monolithic only is 0.005mg; belong to the denier product; because the drug content of this product is the 0.005mg/ sheet; with respect to a sheet heavily for its shared percentage ratio the tablet of 0.06g only be ten thousand/; the weight of supposing 1 dust is greatly about about 0.01mg; the weight of a hair of male is greatly about about 0.5mg; just require every weight that contains principal agent to differ the hair weight that is about 1/10 dust or 1/500, evenly more there is certain degree of difficulty in the content that reach every tablet of medicine.
Existing manufacturing technique is example with the ethinylestradiol:
1. form:
| 1,800,000 of inventorys | ||
| The name of an article | Inventory (kg) | Purposes |
| Ethinylestradiol | 0.009 | Principal agent |
| Icing Sugar | 14.40 | In add |
| Starch | 6.00 | Mix and beat |
| Starch | 55.80 | In add adjuvant |
| Starch | 1.98 | Dash the slurry adjuvant |
| Icing Sugar | 21.60 | Dash the slurry adjuvant |
| Dextrin | 1.98 | Dash the slurry adjuvant |
| Magnesium stearate | 1.26 | Add adjuvant |
| Gross weight | 103.029 |
2. production technology
(1) starch and dextrin are all crossed 80 orders, and Saccharum Sinensis Roxb. 60 mesh sieves are beaten powder;
(2) ethinylestradiol 0.009Kg adds starch 1Kg, after beating with WF-180 (120 order) is mixed, adds 5Kg starch again and beats with WF-180 (120 order) is mixed;
(3) with starch 2.9Kg, white dextrin 6.3Kg, Icing Sugar 19.6Kg drops into successively and joins the slurry bucket, adds the mixing slurry of 100 ℃ of purified water (stirring of limit edged) to 49.5Kg, uses when being cooled to room temperature;
(4) by technology preparation pregelatinized Starch 17Kg, raw material are mixed beat powder 6.0225Kg, Icing Sugar 14Kg, starch 41Kg drops into truck successively, then truck is pushed a body;
(5) mixing of material, preheating under the situation of setting 50-75 ℃ of air intake, mixed 3 minutes and make the temperature of charge preheating in the time of 30-38 ℃, carried out spray granulation;
(6) do uniform particles ground and add magnesium stearate 1Kg after, through pelletizing machine 4# sieve plate granulate.
(7) amount control: ethinylestradiol 90-110%
See Fig. 1.
3. technological parameter
| Sequence number | Project | Parameter |
| 1 | The spray gun type | One rifle three beams |
| 2 | Atomisation pressure | ≥3.8bar |
| 3 | Spouting velocity | 0.8-1kg/min |
| 4 | Slurry temperature | Room temperature |
| 5 | The whitewashing amount | 49.5kg/ pot |
| 6 | Inlet temperature | 50-75℃ |
| 7 | Temperature of charge | 30-38℃ |
| 8 | Leaving air temp | ≤40℃ |
| 9 | The shake number of times | 8-12 time |
| 10 | Shake at interval | 2-3 minute |
4. finished product content analysis result
| Content | Content | Content | |
| 1 | 104.95％ | 98.10％ | 90.90％ |
| 2 | 91.74％ | 87.10％ | 107.10％ |
| 3 | 87.73％ | 99.10％ | 97.30％ |
| 4 | 104.33％ | 105.10％ | 104.30％ |
| 5 | 106.08％ | 109.30％ | 111.00％ |
| 6 | 92.50％ | 104.10％ | 95.92％ |
| 7 | 88.28％ | 90.10％ | 105.67％ |
| 8 | 103.51％ | 97.90％ | 92.90％ |
| 9 | 102.47％ | 104.60％ | 93.20％ |
| 10 | 107.32％ | 93.90％ | 91.67％ |
| On average | 98.89％ | 98.93％ | 99.00％ |
| S | 7.83 | 7.07 | 7.34 |
| A | 1.11 | 1.07 | 1.00 |
| A+1.8S | 15.21 | 13.79 | 14.21 |
Though this production technology can reach the expection requirement, still, its result is in a kind of critical state, belongs to labile state, especially for the requirement of the Chinese Pharmacopoeia uniformity≤15%, still has a certain distance.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and research design can make and contain the production technology that the denier medicine is uniformly distributed in tablet.
Denier of the present invention is meant that drug content is 2.000～0.005mg/ sheet.
Design principle of the present invention is for adopting fluidized-bed spray granulation technology, principal agent is dissolved in advance in the medicinal solvent of 100 times of amounts, make the principal agent raw material be converted into free molecularity (state of tinyization) by original crystalline state, it is that to be the granules of accessories of fluidized state in the container adsorbed that principal agent solution is made tiny drips of solution with spray pattern, and then fully mix with relevant auxiliary materials, ethanol then volatilizees because of heating and can be used after reclaiming again, when the alcoholic solution that contains principal agent has sprayed, principal agent is even attitude with the most tiny particle diameter and is distributed among the adjuvant, spray into binding agent with conventional method at last and fixed, make it formation and contain the medicine homogeneous granules.Thereby reach the requirement of uniformity of dosage units.
The invention provides a kind of preparation production technique that contains the denier medicine, this technology comprises the following steps:
1. form
| Inventory (ten thousand numbers) | 1,800,000 | |
| The name of an article | Inventory (kg) | Purposes |
| Ethinylestradiol | 0.009 | Principal agent |
| Alcohol 95 % | 12.00 | Solvent |
| Distilled water | 4.00 | Solvent |
| Pregelatinized Starch | 16.00 | In add adjuvant |
| Icing Sugar | 13.00 | In add adjuvant |
| Starch | 43.20 | In add adjuvant |
| Starch | 2.70 | Dash the slurry adjuvant |
| Dextrin | 5.40 | Dash the slurry adjuvant |
| Icing Sugar | 18.00 | Dash the slurry adjuvant |
| Magnesium stearate | 0.90 | Add adjuvant |
| Gross weight | 99.21 | |
2. production technology
(1) starch and dextrin use after all crossing the 70-90 mesh sieve, and Icing Sugar is crossed 60 orders after beating powder with dusting cover;
(2) with raw material ethinylestradiol 0.01kg, be dissolved in 13.33kg ethanol after, add the 4.44kg distilled water again, be one group;
(3) with starch 3Kg, dextrin 6Kg, Icing Sugar 20Kg drops into successively and joins in the slurry bucket, adds 100 ℃ of pure water, and the limit edged is stirred to the mixing slurry binding agent of 55Kg, uses when being cooled to room temperature;
(4) with amylum pregelatinisatum 17.77Kg, Icing Sugar 14.223Kg, starch 48Kg drops into truck successively, then truck is pushed a body;
(5) mixing of material setting preheating under 50-75 ℃ of situation of inlet temperature, mixed 3 minutes, when making the temperature of charge preheating at 30-38 ℃, carry out spray granulation, spray the alcoholic solution of ethinylestradiol during operation earlier, and then whitewashing, starch temperature control during whitewashing in room temperature, and filter with 100 mesh sieves;
(6) do uniform particles ground and add magnesium stearate 1Kg after, through Fast granulate machine with No. 4 sieve plate granulate;
(7) the dried granule behind the granulate sucks mixer, mixes 10 minutes.
See Fig. 2.
3. technological parameter
| Sequence number | Project | Parameter | Remarks |
| 1 | The spray gun type | One rifle three beams | / |
| 2 | The spray gun height | High | / |
| 3 | Atomisation pressure | ≥3.8bar | / |
| 4 | Spouting velocity | 0.8-1kg/min | / |
| 5 | Slurry temperature | Room temperature | / |
| 6 | The whitewashing amount | The 55kg/ pot | / |
| 7 | Inlet temperature | 50-75℃ | / |
| 8 | Temperature of charge | 30-38℃ |
| 9 | Leaving air temp | ≤40℃ | / |
| 10 | The shake number of times | 8-12 time | / |
| 11 | Shake at interval | 2-3 minute | / |
| 12 | Drop temperature | 40-44℃ | / |
4. finished product content analysis result
| Sampling | Content | Content | Content |
| 1 | 103.95％ | 100.10％ | 100.90％ |
| 2 | 98.74％ | 97.30％ | 97.10％ |
| 3 | 96.73％ | 99.90％ | 99.10％ |
| 4 | 104.33％ | 103.10％ | 104.30％ |
| 5 | 103.08％ | 99.30％ | 101.00％ |
| 6 | 95.50％ | 104.10％ | 99.92％ |
| 7 | 94.28％ | 97.10％ | 95.67％ |
| 8 | 104.51％ | 98.90％ | 94.90％ |
| 9 | 102.47％ | 102.20％ | 100.00％ |
| 10 | 101.32％ | 96.90％ | 93.67％ |
| On average | 100.49％ | 99.89％ | 98.66％ |
| S | 3.87 | 2.54 | 3.27 |
| A | 0.49 | 0.11 | 1.34 |
| A+1.8S | 7.46 | 4.69 | 7.23 |
Annotate: this method of inspection is with reference to the high-efficient liquid phase technique under 24 editions Related product items of British Pharmacopoeia.
Production technology of the present invention can make the particle diameter of principal agent be controlled at minimum limiting the quantity of, and makes under the situation of principal agent denier 0.005mg/ sheet and distribute equably, has promoted the quality of medicine greatly.Production technology of the present invention can be used to prepare the preparation that contains the denier medicine, is particularly useful for the hormones preparation.
Description of drawings
The technological process of production figure of Fig. 1 prior art
Fig. 2 technological process of production figure of the present invention
The specific embodiment
Embodiment 1.
1. form
| Inventory (ten thousand numbers) | 1,800,000 | |
| The name of an article | Inventory (kg) | Purposes |
| Ethinylestradiol | 0.009 | Principal agent |
| Alcohol 95 % | 12.00 | Solvent |
| Distilled water | 4.00 | Solvent |
| Pregelatinized Starch | 16.00 | In add adjuvant |
| Icing Sugar | 13.00 | In add adjuvant |
| Starch | 43.20 | In add adjuvant |
| Starch | 2.70 | Dash the slurry adjuvant |
| Dextrin | 5.40 | Dash the slurry adjuvant |
| Icing Sugar | 18.00 | Dash the slurry adjuvant |
| Magnesium stearate | 0.90 | Add adjuvant |
| Gross weight | 99.21 | |
2. production technology
(1) starch and dextrin use after all crossing the 70-90 mesh sieve, and Icing Sugar is crossed 60 orders after beating powder with dusting cover;
(2) with raw material ethinylestradiol 0.01kg, be dissolved in 13.33kg ethanol after, add the 4.44kg distilled water again, be one group;
(3) with starch 3Kg, dextrin 6Kg, Icing Sugar 20Kg drops into successively and joins in the slurry bucket, adds 100 ℃ of pure water, and the limit edged is stirred to the mixing slurry binding agent of 55Kg, uses when being cooled to room temperature;
(4) with amylum pregelatinisatum 17.77Kg, Icing Sugar 14.223Kg, starch 48Kg drops into truck successively, then truck is pushed a body;
(5) mixing of material setting preheating under 50-75 ℃ of situation of inlet temperature, mixed 3 minutes, when making the temperature of charge preheating at 30-38 ℃, carry out spray granulation, spray the alcoholic solution of ethinylestradiol during operation earlier, and then whitewashing, starch temperature control during whitewashing in room temperature, and filter with 100 mesh sieves;
(6) do uniform particles ground and add magnesium stearate 1Kg after, through Fast granulate machine with No. 4 sieve plate granulate;
(7) the dried granule behind the granulate sucks mixer, mixes 10 minutes.
See Fig. 2.
3. technological parameter
| Sequence number | Project | Parameter | Remarks |
| 1 | The spray gun type | One rifle three beams | / |
| 2 | The spray gun height | High | / |
| 3 | Atomisation pressure | ≥3.8bar | / |
| 4 | Spouting velocity | 0.8-1kg/min | / |
| 5 | Slurry temperature | Room temperature | / |
| 6 | The whitewashing amount | The 55kg/ pot | / |
| 7 | Inlet temperature | 50-75℃ | / |
| 8 | Temperature of charge | 30-38℃ | |
| 9 | Leaving air temp | ≤40℃ | / |
| 10 | The shake number of times | 8-12 time | / |
| 11 | Shake at interval | 2-3 minute | / |
| 12 | Drop temperature | 40-44℃ | / |
4. finished product content analysis result
| Sampling | Content | Content | Content |
| 1 | 103.95％ | 100.10％ | 100.90％ |
| 2 | 98.74％ | 97.30％ | 97.10％ |
| 3 | 96.73％ | 99.90％ | 99.10％ |
| 4 | 104.33％ | 103.10％ | 104.30％ |
| 5 | 103.08％ | 99.30％ | 101.00％ |
| 6 | 95.50％ | 104.10％ | 99.92％ |
| 7 | 94.28％ | 97.10％ | 95.67％ |
| 8 | 104.51％ | 98.90％ | 94.90％ |
| 9 | 102.47％ | 102.20％ | 100.00％ |
| 10 | 101.32％ | 96.90％ | 93.67％ |
| On average | 100.49％ | 99.89％ | 98.66％ |
| S | 3.87 | 2.54 | 3.27 |
| A | 0.49 | 0.11 | 1.34 |
| A+1.8S | 7.46 | 4.69 | 7.23 |
Embodiment 2.
1, forms
| Ten thousand numbers | 2,000,000 | |
| The name of an article | Inventory | Purposes |
| Ethinylestradiol | 0.010 | Principal agent |
| Cyproterone | 4.000 | Principal agent |
| Alcohol 95 % | 13.000 | Solvent |
| Distilled water | 4.000 | Solvent |
| Pregelatinized Starch | 18.000 | In add adjuvant |
| Icing Sugar | 14.000 | In add adjuvant |
| Starch | 48.000 | In add adjuvant |
| Starch | 3.000 | Dash the slurry adjuvant |
| Dextrin | 6.000 | Dash the slurry adjuvant |
| Icing Sugar | 20.000 | Dash the slurry adjuvant |
| Magnesium stearate | 1.000 | Add |
| Gross weight | 110.010 |
2,1. process implementing carries out according to embodiment.
3, finished product content analysis result
| Sampling | Content | Content | Content |
| 1 | 101.50％ | 99.10％ | 100.10％ |
| 2 | 99.74％ | 99.30％ | 99.10％ |
| 3 | 96.73％ | 97.90％ | 99.80％ |
| 4 | 102.33％ | 102.10％ | 102.30％ |
| 5 | 101.07％ | 100.30％ | 103.00％ |
| 6 | 98.50％ | 101.10％ | 101.92％ |
| 7 | 97.28％ | 99.10％ | 98.67％ |
| 8 | 103.51％ | 98.90％ | 98.90％ |
| 9 | 105.47％ | 103.20％ | 99.00％ |
| 10 | 100.32％ | 95.90％ | 97.67％ |
| On average | 100.65％ | 99.69％ | 100.05％ |
| S | 2.74 | 2.10 | 1.77 |
| A | 0.65 | 0.31 | 0.05 |
| A+1.8S | 5.57 | 4.08 | 3.23 |
Claims (2)
1. a preparation production technique that contains denier medicine drug content at the 2.000-0.005mg/ sheet is characterized in that this technology comprises the following steps:
(1) starch and dextrin use after all crossing the 70-90 mesh sieve, and Icing Sugar is crossed 60 orders after beating powder with dusting cover;
(2) with raw material ethinylestradiol 0.01kg, be dissolved in 13.33kg ethanol after, add the 4.44kg distilled water again, be one group;
(3) with starch 3Kg, dextrin 6Kg, Icing Sugar 20Kg drops into successively and joins in the slurry bucket, adds 100 ℃ of pure water, and the limit edged is stirred to the mixing slurry binding agent of 55Kg, uses when being cooled to room temperature;
(4) with amylum pregelatinisatum 17.77Kg, Icing Sugar 14.223Kg, starch 48Kg drops into truck successively, then truck is pushed a body;
(5) mixing of material setting preheating under 50-75 ℃ of situation of inlet temperature, mixed 3 minutes, when making the temperature of charge preheating at 30-38 ℃, carry out spray granulation, spray the alcoholic solution of ethinylestradiol during operation earlier, and then whitewashing, starch temperature control during whitewashing in room temperature, and filter with 100 mesh sieves;
(6) do uniform particles ground and add magnesium stearate 1Kg after, through Fast granulate machine with No. 4 sieve plate granulate;
(7) the dried granule behind the granulate sucks mixer, mixes 10 minutes.
2. a kind of production technology that contains the preparation of denier medicine according to claim 1 is characterized in that wherein said processing parameter is:
Sequence number item argument remarks
1 spray gun type, one rifle three beams/
2 spray gun height height/
3 atomisation pressures 〉=3.8bar/
4 spouting velocity 0.8-1kg/min/
5 slurry temperature room temperatures/
6 whitewashing amount 55kg/ pots/
7 inlet temperature 50-75 ℃/
8 temperature of charge 30-38 ℃
9 leaving air temps≤40 ℃/
10 shake number of times 8-12 time/
11 shakes 2-3 minute at interval/
12 drop temperature 40-44 ℃/.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100536087A CN1307974C (en) | 2004-08-10 | 2004-08-10 | Process for preparing formulation containing infinitesimal medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100536087A CN1307974C (en) | 2004-08-10 | 2004-08-10 | Process for preparing formulation containing infinitesimal medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1732906A CN1732906A (en) | 2006-02-15 |
| CN1307974C true CN1307974C (en) | 2007-04-04 |
Family
ID=36075662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100536087A Expired - Lifetime CN1307974C (en) | 2004-08-10 | 2004-08-10 | Process for preparing formulation containing infinitesimal medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1307974C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674756B (en) * | 2019-02-19 | 2021-03-16 | 河北君临药业有限公司 | Clenbuterol hydrochloride tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063822A2 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
-
2004
- 2004-08-10 CN CNB2004100536087A patent/CN1307974C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063822A2 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
Non-Patent Citations (1)
| Title |
|---|
| 喷雾法使饲料中微量元素的添加更加均匀 张平远，水产科技情报，第29卷第5期 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1732906A (en) | 2006-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1204882C (en) | Directly compressible, ultra fine acetaminophen compositions and process for producing same | |
| CN1177787C (en) | Powdery mannitol and preparation method thereof | |
| CN1298313C (en) | Pre-formulation for the tabletting of natural mixtures of conjugated estrogens | |
| CN1074228A (en) | Microcrystalline celluiose spheronization composition | |
| CN1426297A (en) | Directly compressed solid dosage particles | |
| CN1268888A (en) | Granule free of excipients | |
| CN1087185C (en) | Process and apparatus for agglomeration of hydrolytically sensitive substances by means of steam | |
| CN1307974C (en) | Process for preparing formulation containing infinitesimal medicine | |
| CN1309375C (en) | Granulating process of medicinal material and supplementary material for dispensing directly | |
| CN1872029A (en) | Spherical particles of taurine, and preparation method | |
| CN1899618A (en) | Process for preparing micro crystal cellulose milk sugar | |
| CN104224726A (en) | Preparation method of traditional Chinese medicine pellet | |
| CN113975241B (en) | Preparation process of trelagliptin succinate tablets | |
| CN1537882A (en) | Granulating of nonionic cellulose ether | |
| CN106806132A (en) | It is a kind of to be suitable to the method for granulating of viscous material | |
| CN1793064A (en) | Pelletization of lemery salt | |
| CN1237964C (en) | Method for preparing composition granules containing ibuprofen amino guanidyl valeric acid | |
| CN1045440C (en) | Production of beta-form thiamine hydrochloride crystals | |
| CN106389368A (en) | Sodium valproate sustained release preparation as well as preparation process and applications thereof | |
| CN1634045A (en) | Compound famotidine chewing tablet preparation method | |
| CN1049114C (en) | Method for prepn. of slowly-released medicaments preparation | |
| CN1285265C (en) | Monosultap granules and its preparation method | |
| CN101036658A (en) | Hydrochlorothiazide grain and sugar-coat producing technique of compound luobuma tablets | |
| CN1943787A (en) | A damp proof composition for pharmaceutical and its preparation methods | |
| CN100431527C (en) | Chinese medicine bolus preparing process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI XINYI TIANPING PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANGHAI SINE KANGJIE PHARMACEUTICAL CO., LTD. Effective date: 20120222 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201419 FENGXIAN, SHANGHAI TO: 201108 MINHANG, SHANGHAI |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20120222 Address after: 201108, Minhang District, Shanghai, No. 4598 Kim Patentee after: SHANGHAI XINYI TIANPING PHARMACEUTICAL CO.,LTD. Address before: 201419 Spark Development Zone, Shanghai, Fengxian District Patentee before: Shanghai Sine Kangjie Pharmaceutical Co.,Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20070404 |
|
| CX01 | Expiry of patent term |