CN1872029A - Spherical particles of taurine, and preparation method - Google Patents
Spherical particles of taurine, and preparation method Download PDFInfo
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- CN1872029A CN1872029A CNA2006100194888A CN200610019488A CN1872029A CN 1872029 A CN1872029 A CN 1872029A CN A2006100194888 A CNA2006100194888 A CN A2006100194888A CN 200610019488 A CN200610019488 A CN 200610019488A CN 1872029 A CN1872029 A CN 1872029A
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- taurine
- exsiccator
- spherical particle
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Abstract
A spherical taurine particle used as the raw material of medicine, and the additive of food or forage has a structure formula: H2N-CH2-CH2-SO3H. It is prepared through dissolving taurine in purified water, drying and granulating.
Description
Technical field
The present invention relates to a kind of taurine and preparation method thereof, specifically a kind of spherical particle taurine and preparation method thereof.
Background technology
Taurine is a kind of nonprotein amino acid; as medicinal it have antiinflammatory, analgesic, calm, analgesia, convulsion and effect such as bring high blood pressure down; to infant brain development, nerve conduction, visual function improve and calcium be absorbed with good action; taurine has a series of unique functions to cardiovascular system; energy health invigorating, relieving fatigue; make taurine gradually in medical treatment because have all functions, fields such as health care of food are widely used.
The taurine structure is as follows:
H
2N-CH
2-CH
2-SO
3H
Its chemistry is by name: 2-aminoethyl sulfonic acid, year consumption of present taurine in the world is above 1.5 ten thousand tons/year, the annual production of China's taurine is about 3000 tons, wherein 90% is used for outlet, along with economic development and people raising to taurine understanding, the demand of taurine also will further increase, and the also following present known taurine of problem is with the acicular crystal of water as solvent, and the powdery of conventional usefulness, its flowability of the taurine of existing crystal formation is poor, easily lump the moistureproof anti-poor performance of pressing, unsuitable long term store, long-distance transport; Also because it is subjected to the restriction of crystal formation, its dissolubility, bad dispersibility are used inconvenience, and how to address the above problem is the problem that present many taurine producer faces.Through inventor's research, the crystal formation and the crystal grain that change taurine are to solve one of storage, awkward feasible method.
Summary of the invention
The objective of the invention is for solving the problems of the technologies described above; the defective that overcomes existing taurine crystal formation provides a kind of novel crystal forms of taurine; its good fluidity; good dispersion; dissolubility is good, and prevented from caking can satisfy all requirements as preparation raw material, food additive, feed additive; convenient simultaneously the storage is convenient to transportation.
Discover through the inventor:
Taurine flowability and dispersibility and its crystal formation and crystal grain size in use has substantial connection.
A, from the crystal shape analysis, mobile performance: spherical particle is better than square granule, is better than cylindrical particle, is better than elongated piece.Connection
B, mobile from the analysis of crystal grain size, bulky grain is better than granule, and single-size is better than non-uniform granular.
C, analyze dispersive property from crystal grain size, granule is better than bulky grain and is better than nano sized particles.
Caking capacity and its crystal formation and the crystal formation size of taurine in storage process has close relation; on the ordinary meaning; the crystal formation that big crystal formation and surface area are little is compared prevented from caking; the crystal formation of drug molecule and the flowability of medicine, dissolubility, dispersibility, caking capacity are closely related; on the ordinary meaning, the crystal formation of drug molecule is even, and specific surface area is little; have better flowability, dispersibility, show different storages, serviceability.
Taurine novel crystal forms among the present invention is a kind of spherical particle, and particle diameter is the 10-200 order, and preferred particle diameter is the 80-120 order, most preferably is 100 orders.Granule is a not only good fluidity of 80-120 purpose spherical particle taurine as mentioned above, and its dispersive property is also very good.
Preparation method of the present invention may further comprise the steps:
(1), in blending tank with taurine mix homogeneously soluble in water, make waterborne suspension, then waterborne suspension is transported in the exsiccator by pump.
(2), the inlet temperature in the exsiccator is controlled at 250-150 ℃, return air temperature is controlled at 100 ℃, the taurine waterborne suspension of input is passed through the shower nozzle A ejection of exsiccator, the pelletize oven dry, with the taurine waterborne suspension carry finish after, treat in exsiccator, to take out taurine particles after inlet temperature is reduced to 80 ℃;
(3), the granule that makes 200 mesh sieves excessively, preferable separate sieve or filter screen are spherical particle taurine of the present invention less than 200 purposes.
That sifts out can also turn back in the exsiccator recycling by conveyer device greater than particle diameter 200 purpose taurine fine powders again.
Exsiccator preferably spray drying device or fluidized bed dryer that exsiccator the inventive method among the present invention is used, in the present invention simultaneously, the inventor has done necessary improvement to exsiccator:
(1) in the practical operation, part taurine dust can promptly cause wastage of material, also contaminated air because the wind-force effect is discharged from air outlet.At this problem, among the present invention, described exsiccator return air inlet place also is provided with cleaner unit, can remove the taurine dust in the air-out, is carried back in the exsiccator the preferred cyclone separator of described cleaner unit again by the isolated taurine dust of cleaner unit.
(2) have two shower nozzles in the exsiccator among the present invention, one is the suspension shower nozzle, and another is the dry powder shower nozzle, and the suspension shower nozzle is used for the conventional taurine waterborne suspension of carrying; The dry powder shower nozzle connect another set of conveyer device be used for carrying from bolter separate obtain greater than 200 purpose taurine fine powders and from cleaner unit isolated taurine dust; described dry powder shower nozzle and suspension shower nozzle spray simultaneously; the waterborne suspension that the fine powder of dry powder shower nozzle ejection is sprayed by the suspension shower nozzle mixes in exsiccator and is wrapped up rapidly, the oven dry pelletize.
By improvement, make to go out of use or bring the raw material of pollution to be reclaimed as much as possible to exsiccator.
This process can circulate and carry out repeatedly, has saved raw material, has reduced the pollution of dust to air, the concordance on the finished form size that can guarantee to make simultaneously.
The solid content of preferably controlling the taurine waterborne suspension among the present invention is 50%-80%, can guarantee that so dried grain diameter reaches requirement.
The present invention has following beneficial effect
1, good fluidity, good dispersion, dissolubility is good, prevented from caking.
2, the present invention can be used as medicine preparation raw material, food additive, feed additive.
3, the convenient storage is convenient to transportation.
4, reusable edible, conservation purifies air.
Description of drawings
Fig. 1 is the structural representation of exsiccator among the present invention.
The specific embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1: the preparation of spherical particle taurine
Start spray dryer, the intensification preheating is dissolved in the 5kg taurine in the 5kg pure water simultaneously; make solid content and be 50% waterborne suspension, device inlet temperature to be dried rises to 250 ℃, 100 ℃ of return air; start membrane pump suspension is delivered to spray dryer; keep out temperature to mass transport to finish, treat that inlet temperature reduces to 80 ℃, stop exsiccator; take out taurine product 9kg (moisture content=0.07%; content 99.2%), particle size distribution such as following table, (getting the 200g screening)
Embodiment 2: the preparation of spherical particle taurine
Start spray dryer; the intensification preheating; simultaneously with the 15kg taurine; be dissolved in the 5kg pure water; make solid content and be 75% waterborne suspension; device inlet temperature to be dried rises to 250 ℃; 100 ℃ of return air; start plunger displacement pump waterborne suspension is delivered to spray dryer oven dry pelletize, start the taurine particles of bolter after and separate, will isolatedly send back in the exsiccator by conveyer device and spray from dry product shower nozzle 2 greater than 200 purpose fine powders to pelletize; mixed in spray dryer with the waterborne suspension of the taurine of suspension shower nozzle 1 ejection; dry pelletize again; keep out temperature to mass transport to finish, treat that inlet temperature reduces to 80 ℃, stop exsiccator; taking-up is less than 200 purpose spherical particle taurine product 9kg (moisture content=0.07%; content 99.2%), particle size distribution such as following table, (getting the 200g screening)
Embodiment 3: the preparation of spherical particle taurine
Start spray dryer; the intensification preheating; simultaneously with the 10kg taurine; be dissolved in the 2.5kg pure water; make solid content and be 80% waterborne suspension; device inlet temperature to be dried rises to 250 ℃; 100 ℃ of return air; start plunger displacement pump waterborne suspension is delivered to spray dryer oven dry pelletize, start the taurine particles of bolter after and separate, will isolatedly send back in the exsiccator by conveyer device and spray from dry product shower nozzle 2 greater than 200 purpose fine powders to pelletize; mixed in spray dryer with the waterborne suspension of the taurine of suspension shower nozzle 1 ejection; dry pelletize again; keep out temperature to mass transport to finish, treat that inlet temperature reduces to 80 ℃, stop exsiccator; taking-up is less than 200 purpose spherical particle taurine product 9kg (moisture content=0.07%; content 99.2%), particle size distribution such as following table, (getting the 200g screening)
Embodiment 4: the preparation of spherical particle taurine
Start fluidized bed dryer, the intensification preheating, simultaneously with the 10kg taurine, it is that 67% waterborne suspension is poured in the hopper that pure water 5kg makes solid content, device inlet temperature to be dried rises to 150 ℃, 100 ℃ of return air start membrane pump suspension are delivered in the fluidized bed dryer, keep out temperature to mass transport to finish; To send exsiccator again back to by the isolated taurine dust of the cyclone separator on the fluidized bed dryer exhaust outlet,, in exsiccator, mix the oven dry pelletize with the taurine waterborne suspension of suspension shower nozzle 1 ejection by 2 ejections of dry product shower nozzle.Treat that inlet temperature reduces to 80 ℃, stop exsiccator, take out taurine product 8.5kg (moisture content=0.09%, content 99.2%), particle size distribution such as following table, (getting the 200g screening)
Embodiment 5: mobile, caking performance is investigated.
By with the taurine of traditional taurine goods and spherical particle of the present invention mobile,
Product of the present invention and traditional is investigated in contrast on caking capacity, dispersibility and the dissolubility
Difference between the taurine goods.
1, fluidity test
The finished product of embodiment 1 is got 100g (A), will have crystal formation now and get 100g (B), be poured into outlet respectively in the funnel of 10mm, the A sample is quicksand like and spills, and the B sample is difficult to flow out, and needs the rapping funnel just to spill.The results are shown in following table:
| A | 10 seconds | 110-120℃ | Quicksand like |
| B | 55 seconds | 90-100℃ | Become bulk |
Result of the test shows that product of the present invention is quicksand like and flows out, and the delivery time is short, is difficult for agglomerating; And contrast product is difficult for flowing out, and becomes bulk.
2, caking capacity test
Above-mentioned A, B sample are packed in the sample sack, push down with the 5kg weight, placed 1 year, it is as follows to observe the caking capacity result:
Result of the test shows that traditional taurine crystal 4 little caking occurred after individual month, promptly occurs heavily luming in 6 months; And the true spherical particle of the present invention is placed and is not lumpd yet after 1 year, has the anti-performance of pressing of excellent protection against the tide, is convenient to store, transport.
Claims (10)
1, a kind of taurine of spherical particle, structural formula are H
2N-CH
2-CH
2-SO
3H is characterized in that it is a kind of spherical particle, and particle grain size is 10 orders-200 orders.
2, according to the taurine of the described spherical particle of claim 1, the particle diameter that it is characterized in that the taurine of described spherical particle is 80 orders-120 orders.
3, according to the taurine of the described spherical particle of claim 1, the particle diameter that it is characterized in that the taurine of described spherical particle is 100 orders.
4, the preparation method of the taurine of any one spherical particle of claim 1 to 3, it may further comprise the steps:
(1), in blending tank, taurine is dissolved in mix homogeneously in the pure water, make waterborne suspension; Then waterborne suspension is transported in the exsiccator by pump.
(2), the inlet temperature in the exsiccator is controlled at 250-150 ℃, return air temperature is controlled at 100 ℃, the taurine waterborne suspension of input is sprayed by shower nozzle, the pelletize oven dry, with the taurine waterborne suspension carry finish after, treat in exsiccator, to take out taurine particles after inlet temperature is reduced to 80 ℃;
(3), the granule that makes 200 mesh sieves excessively, be spherical particle taurine of the present invention less than 200 purposes.
5, as the preparation method of the taurine of a kind of spherical particle as described in the claim 4, the solid content that it is characterized in that the taurine waterborne suspension in the step (1) is 50%-80%.
6, as the preparation method of the taurine of spherical particle as described in the claim 4, it is characterized in that described exsiccator is spray dryer or fluidized bed dryer, two shower nozzles are housed in the exsiccator, one is the suspension shower nozzle, and another is the dry powder shower nozzle.
7, as the preparation method of the taurine of a kind of spherical particle as described in the claim 4; it is characterized in that it also comprises the steps: to send back in the exsiccator again greater than 200 purpose taurine fine powders in the step (3); by the dry powder shower nozzle ejection of exsiccator, the taurine waterborne suspension that sprays simultaneously with the suspension shower nozzle mixes, dries pelletize in exsiccator.
8, as the preparation method of the taurine of spherical particle as described in claim 5 or 6; the air outlet that it is characterized in that exsiccator also is provided with cleaner unit; the isolated taurine dust of cleaner unit is sent back in the exsiccator again by the ejection of dry powder shower nozzle, and the taurine waterborne suspension that sprays simultaneously with the suspension shower nozzle mixes, dries pelletize in exsiccator.
9, the preparation method of the taurine of spherical particle as claimed in claim 7; it is characterized in that in the step (3) taurine particles that makes in the exsiccator directly being imported 200 order filter screens; obtain greater than 200 purpose taurine fine powders; and in cleaner unit, separate the taurine fine powder that obtains and send back in the exsiccator by conveyer device, from the dry powder shower nozzle, spray.
10, the preparation method of the taurine of spherical particle as claimed in claim 8 is characterized in that described cleaner unit is a cyclone separator.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100194888A CN100398096C (en) | 2006-06-29 | 2006-06-29 | Spherical particles of taurine, and preparation method |
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|---|---|---|---|
| CNB2006100194888A CN100398096C (en) | 2006-06-29 | 2006-06-29 | Spherical particles of taurine, and preparation method |
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|---|---|
| CN1872029A true CN1872029A (en) | 2006-12-06 |
| CN100398096C CN100398096C (en) | 2008-07-02 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2239251A1 (en) | 2009-04-08 | 2010-10-13 | Rheln Pharma Consult GmbH | Process for refining 2-aminoethanesulfonic acid from crude 2-aminoethane-sulfonic acid, 2-aminoethanesulfonic acid obtained there from and use thereof |
| CN101904819A (en) * | 2010-08-20 | 2010-12-08 | 湖北远大富驰医药化工股份有限公司 | Method for preparing taurine particles |
| CN103848763A (en) * | 2014-03-20 | 2014-06-11 | 天津大学 | Method for changing morphology of taurine crystals by adopting organic carboxylic acid or organic carboxylate additives |
| CN105293831A (en) * | 2015-11-20 | 2016-02-03 | 潜江永安药业股份有限公司 | Processing technology of taurine production sewage |
| CN106025198A (en) * | 2016-05-19 | 2016-10-12 | 宁波中科孚奇能源科技有限公司 | Lead-carbon composite material preparation method |
| US9907754B2 (en) | 2013-03-28 | 2018-03-06 | Vectura Limited | Taurine compositions suitable for inhalation |
| CN109574886A (en) * | 2018-11-19 | 2019-04-05 | 万华化学集团股份有限公司 | The taurine crystal and preparation method thereof that a kind of heap density, mobility are improved and do not coalesced |
| EP4296263A1 (en) | 2022-06-22 | 2023-12-27 | Qiangjiang Yongan Pharmaceutical Co., Ltd. | High-efficiency cyclic preparation method for columnar taurine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137267C (en) * | 2001-03-20 | 2004-02-04 | 石子聪 | Process for preparing natural taurine |
-
2006
- 2006-06-29 CN CNB2006100194888A patent/CN100398096C/en active Active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2239251A1 (en) | 2009-04-08 | 2010-10-13 | Rheln Pharma Consult GmbH | Process for refining 2-aminoethanesulfonic acid from crude 2-aminoethane-sulfonic acid, 2-aminoethanesulfonic acid obtained there from and use thereof |
| CN101857558A (en) * | 2009-04-08 | 2010-10-13 | 莱茵制药咨询有限公司 | Make with extra care the method for 2-aminoethyl sulfonic acid, thus obtained 2-aminoethyl sulfonic acid and uses thereof by rough 2-aminoethyl sulfonic acid |
| CN101904819A (en) * | 2010-08-20 | 2010-12-08 | 湖北远大富驰医药化工股份有限公司 | Method for preparing taurine particles |
| CN101904819B (en) * | 2010-08-20 | 2011-10-19 | 湖北远大富驰医药化工股份有限公司 | Method for preparing taurine particles |
| US9907754B2 (en) | 2013-03-28 | 2018-03-06 | Vectura Limited | Taurine compositions suitable for inhalation |
| CN103848763A (en) * | 2014-03-20 | 2014-06-11 | 天津大学 | Method for changing morphology of taurine crystals by adopting organic carboxylic acid or organic carboxylate additives |
| CN103848763B (en) * | 2014-03-20 | 2015-08-12 | 天津大学 | Organic carboxyl acid or organic carboxyl acid salt additives is adopted to change the method for taurine crystal habit |
| CN105293831A (en) * | 2015-11-20 | 2016-02-03 | 潜江永安药业股份有限公司 | Processing technology of taurine production sewage |
| CN106025198A (en) * | 2016-05-19 | 2016-10-12 | 宁波中科孚奇能源科技有限公司 | Lead-carbon composite material preparation method |
| CN106025198B (en) * | 2016-05-19 | 2019-04-16 | 宁波中科孚奇能源科技有限公司 | A kind of preparation method of lead carbon composite |
| CN109574886A (en) * | 2018-11-19 | 2019-04-05 | 万华化学集团股份有限公司 | The taurine crystal and preparation method thereof that a kind of heap density, mobility are improved and do not coalesced |
| EP4296263A1 (en) | 2022-06-22 | 2023-12-27 | Qiangjiang Yongan Pharmaceutical Co., Ltd. | High-efficiency cyclic preparation method for columnar taurine |
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| Publication number | Publication date |
|---|---|
| CN100398096C (en) | 2008-07-02 |
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