CN1283492A - A kind of Tibetan medicine for treating liver diseases and its preparation method - Google Patents

Abstract

The Tibetan medicine for curing liver disease is made up by using pine stone, pearl, coral, rock extract, sandalwood, swertia, carthamus flower, drynaria, ephedra, zollinger, myrobalan, artificial bezoar and musk through the processes of pulverizing, grinding, uniformly mixing and making pill.

Description

A kind of Tibetan medicine for treating liver diseases and its preparation method

The present invention relates to a Tibetan medicine for treating liver diseases and a preparation method thereof, in particular to a kind of medicine which is prepared from pure Chinese and Tibetan medicinal materials and has significant curative effects on chronic hepatitis B, viral hepatitis, liver cirrhosis, liver ascites, etc. , also known as Dongger Sanyiwei Songshijiu, a Tibetan medicine for treating liver diseases and its preparation method.

At present, viral hepatitis is an infectious disease that seriously endangers people's life and health. It has a wide range of prevalence and high incidence, which is unmatched by other infectious diseases. China is a high-incidence area of hepatitis B virus. There are 1 million of them. Among the 5 types of viral hepatitis, hepatitis B and C are most likely to become chronic. It has been confirmed that viral hepatitis is closely related to liver cirrhosis and primary liver cancer. Although Tibetan medicine has unique features in the treatment of liver and gallbladder diseases, and there are many traditional formulas, these traditional formulas need to be further improved and strengthened due to the constant changes in eating habits and other factors.

The object of the present invention is to provide a kind of Tibetan medicine for treating liver disease with high cure rate and quick curative effect on chronic hepatitis B, viral hepatitis such as liver cirrhosis and its preparation method.

The solution of the present invention is based on the theory of traditional Chinese medicine and Tibetan medicine, based on the twenty-five-flavored Songshi pills in "Tibetan Medicine Clinical Notes", referring to "Zhenbao Dari Pills", "Thirteen Flavored Red Flower Pills", "Sixteen Flavored Songshi Pills" The prescriptions of "Stone Pill", "Nanlu Yuejing Pill" and "Qiwei Honghua Zhusheng Pill" have been selected from the treasury of Tibetan medicine in the motherland after more than 20 years of clinical practice, repeated addition, subtraction and processing. turquoise, coral, artificial bezoar, meconopsis five veins, watercress, and saffron; pearls, rock essence paste, stone flower, and rhizoma drynaria with liver protection and detoxification effects; detoxification and health-preserving functions. Zuotai, which can improve the efficacy and prolong the shelf life of medicines; has the functions of clearing away heat, stopping bleeding, and invigorating the spleen, and acts on ephedra, which acts on liver depression, stagnation of qi, blood stasis, and spleen discomfort; has detoxification functions, and is used for various toxicities such as food poisoning Drynaria rhizome and other 31 kinds of medicinal raw materials are mixed and developed into a Tibetan medicine for treating liver diseases with excellent curative effect on liver depression and qi stagnation, liver poisoning, viral hepatitis, hepatitis B, liver cirrhosis and liver ascites and its preparation method.

The purpose of the present invention is achieved in that it consists of turquoise, pearl, coral, silver vermilion, emblica, rock essence paste, white sandalwood, red sandalwood, waved melon seeds, broadwood, nutmeg, clove, watercress, Geranium yellow, grass safflower, saffron, kapok, stone flower, drynaria, ephedra, zotai, cardamom, myrobalan, cinnamon, safflower, artificial bezoar, meconopsis five veins, tangutou It is composed of the compatibility of head, chebula, musk, and Tibetan woody incense, and is prepared by Tibetan medicine processing methods such as crushing, sieving, blending, mixing, pan-pilling, drying, coating, polishing, inspection, and packaging. It is characterized in that it is a Tibetan medicine made from the following components (parts by weight):

Pine Stone 20 Pearl 5

Coral 5 Silver Vermilion 5

Phyllanthus emblica 5 rock extract 5

White Sandalwood 5 Rosewood 5

Poleng melon seeds 5 Guangmuxiang 5

Nutmeg 5 cloves 5

Swertia 10 Tianzhuhuang 5

Grass safflower 10 saffron 0.5

Kapok 5 Stone Flower 5

Drynaria 5 5 Ephedra 2.5

Zuotai 2.5 Grass cardamom 5

Myrobalan 10 Cinnamon 15

Saibei Viola 5 Artificial Bezoar 5

Meconopsis five veins 10 Aconitum tangut 15

Myrobalan 5 5 Musk 0.04

Tibetan woody fragrance 10.

It is also characterized in that: the described Myrobalan and Myrobalan are the cored Myrobalan and Myrobalan.

The preparation method that above-mentioned each component is made Tibetan medicine of the present invention is:

① Grind the famous and precious fine medicinal materials Zuotai, bezoar, saffron and musk into fine powder respectively, and set aside for later use.

②Crush the rest of the medicinal materials except the above-mentioned rare fine medicines into fine powder, sieve,

③ Add Zotai, bezoar, saffron, and musk fine powder to grind, mix well,

④ Add rock extract, add water pan pill,

⑤ Dry until the moisture content is ≤9.0%,

6. coating, lighting, quality inspection, finished product packaging, stockpiling, a kind of Tibetan medicine for treating liver disease of the present invention is obtained.

Compared with the prior art, the present invention has stable quality, safe and convenient administration, fast curative effect, high cure rate and low recurrence rate, and has the functions of clearing away heat and detoxification, soothing liver and promoting gallbladder, and removing blood stasis after taking it. Qi stagnation, blood stasis, liver poisoning, liver pain, liver infiltration, and various acute and chronic hepatitis and cholecystitis, especially for chronic hepatitis B, cirrhosis and other viral hepatitis.

Further illustrate the present invention below in conjunction with embodiment

Example

① Commercially purchased and weighed raw materials with the following weight (g) ratio

Pine Stone 20 Pearl 5

Coral 5 Silver Vermilion 5

Phyllanthus emblica 5 rock extract 5

White Sandalwood 5 Rosewood 5

Poleng melon seeds 5 Guangmuxiang 5

Nutmeg 5 cloves 5

Swertia 10 Tianzhuhuang 5

Grass safflower 10 saffron 0.5

Kapok 5 Stone Flower 5

Drynaria 5 5 Ephedra 2.5

Zuotai 2.5 Grass cardamom 5

Pit Myrobalan 10 Cinnamon 15

Saibei Viola 5 Artificial Bezoar 5

Meconopsis five veins 10 Aconitum tangut 15

Denuclear Myrobalan 5 Musk 0.04

Tibetan woody fragrance 10

②Except for the fine powders of rare and precious herbs (Zuotai, Bezoar, Saffron, Musk) and Yanjing ointment, which are ground into fine powders and passed through a 100-mesh sieve, add the fine powders of precious herbs and grind, mix well, Add appropriate amount of water to pan pills with Yanjing ointment, dry, the water content is 5%, coating, polishing, quality inspection, finished product packaging, and stock to get black water pills, fragrant, bitter and astringent according to the present invention for treating liver diseases It is also known as Dongger Thirty-one Songshi Pills.

The Tibetan medicine of the present invention shows through pharmacodynamics (see attached page), has anti-hepatic necrosis and promotes hepatic cell repair effect, and its immunoregulatory effect has positive significance to eliminating virus, stabilizing body defense ability, and to each liver cirrhosis animal. Indexes all have different degrees of improvement; Toxicology research results show (see attached page), longer course of treatment, larger doses of taking the preparation have no obvious toxic damage to animal hematology, blood biochemistry and important tissues and organs, showing that The preparation has low toxicity and is safe to take orally.

Years of clinical observation results show that the Tibetan medicine of the present invention has significant curative effects on chronic hepatitis B and liver cirrhosis. During the observation period, no obvious adverse reactions were found in the Tibetan medicine of the present invention. It is safe and convenient to take, has obvious protective effects on various experimental liver injuries, obvious anti-fibrosis effects, has immune enhancement effects and promotes liver cell regeneration,

56 cases of chronic hepatitis B and 10 cases of decompensated liver cirrhosis are collected and sorted out in clinical practice. The effective rate for chronic hepatitis B is 32.1%, the effective rate is 60.7%, and the total effective rate is 92.8%. %, the effective rate is 20%, and the total effective rate is 30%. During the clinical practice observation period, no obvious adverse reactions are found in the Tibetan medicine of the present invention. The collected cases are classified as follows:

(1) Tibetan medicine of the present invention treats hepatitis B clinical summary

(1) General information

The diagnosis of chronic hepatitis B is based on the diagnostic criteria revised by the National Viral Hepatitis Academic Association in 1990 (Shanghai), and the diagnosis is made based on the course of disease, symptoms, signs, laboratory tests and serum markers of hepatitis B. Among the 56 cases, 34 were males, accounting for 60.7%, and 22 were females, accounting for 39.2%. The oldest was 59 years old and the youngest was 16 years old. Twenty cases of chronic hepatitis B were randomized and hospitalized at the same time (treated with general liver-protecting drugs). ) as a control, 13 males and 7 females, aged 18-55 years.

(2) Treatment and curative effect

Treatment: 1 pill each time, twice a day, each pill weighs 19, one month is a course of treatment.

Efficacy:

① Curative effect standard

Markedly effective: normal appetite, disappearance of abdominal distension, nausea, and diarrhea, elimination of fatigue, reduction of hepatomegaly, softening to moderate in those with moderate or higher texture, and normal liver function;

Effective: the above symptoms disappeared, the texture of the liver remained unchanged, and the liver function improved compared to before;

Invalid: Compared with before treatment, there is no obvious improvement in all aspects.

② curative effect

therapy group

The effective rate is 32.1% (18/56); the effective rate is 60.7% (34/56);

Ineffective rate 7.1% (4/56); total effective rate 92.8% (52/56)

The total effective rate of the control group was 35% (7/20), that is, the treatment group was significantly higher than the control group.

(2) clinical summary of drug treatment of liver cirrhosis of the present invention

Liver cirrhosis is a common and stubborn chronic disease with great harm and no specific treatment, and there is no sure cure in the existing society. Yet take Tibetan medicine treatment of the present invention 10 cases, short-term effect is satisfactory.

(1) Clinical data

There were 10 cases in this group, including 6 males and 4 females, the oldest was 64 cases, and the youngest was 19 years old.

(2) Clinical manifestations:

The main symptoms are liver pain, fatigue, abdominal distension, fever, jaundice, splenomegaly, hepatomegaly, ascites, etc. However, during the development of liver cirrhosis, due to different changes in different periods and pathological anatomy or accompanying other diseases, there may be various rare clinical manifestations, which often lead to misdiagnosis or missed diagnosis. Some in this group showed acute abdomen (cholecystitis, cholelithiasis), some showed obstructive jaundice, some hepatomegaly was obviously uneven and suspected to be liver cancer, and some had systemic edema and abnormal urine samples, showing Kidney disease, etc., 10 cases in this group were diagnosed based on symptoms, signs, liver function, ultrasound and other items, combined with clinical analysis.

(3) Treatment:

Oral medicine of the present invention is taken twice a day, sooner or later each time, and is taken after meal, one pill, and the dosage of every pill is 1 gram.

(4) Curative effect standard

Significantly effective: the size of the liver and spleen is normal, the liver damage subsides, and the subjective symptoms disappear.

Effective: the liver and spleen are retracted, and the subjective symptoms are relieved.

Ineffective: After 1-2 courses of treatment, the liver damage and subjective symptoms were not relieved.

(5) curative effect

6 cases were markedly effective, accounting for 60%, 2 cases were effective, accounting for 20%, 2 cases were ineffective, accounting for 20%, the total effective rate was 80%

Claims (3)

1; a kind of Tibetan medicine for the treatment of hepatopathy; it is by tophus; Margarita; Corallium Japonicum Kishinouye; Vermilion; Fructus Phyllanthi; Mumiyah-asil; Santalum album; Lignum pterocarpi indici; Herpetospermum caudigerum Wall.; Radix Aucklandiae (Radix Vladimiriae); Semen Myristicae; Flos Caryophylli; Herba Swertiae bimaculatae; Concretio Silicea Bambusae; Flos Carthami; Stigma Croci; Flos Bombacis Malabarici; Parmelia saxatilis Ach.; Rhizoma Drynariae; Herba Ephedrae; ZUOTAI; Semen Alpiniae Katsumadai; the Fructus Chebulae; Cortex Cinnamomi; Corydalisimpatiens(Pall.)Fisch; the artificial Calculus Bovis; Flos meconopsis quintuplinerviae; Tangut aconite; Fructus Terminaliae Billericae; Moschus; the Radix Inulae compatibility is formed; through pulverizing; sieve; facing-up; mixing; general nine; dry; coating; polishing; check; packing waits the Tibetan medicine processing and concocting method to be prepared from, and it is characterized in that it is the medicine of being made by following component (weight portion):

Tophus 20 Margaritas 5

Corallium Japonicum Kishinouye 5 Vermilion 5

Fructus Phyllanthi 5 Mumiyah-asil 5

Santalum album 5 Lignum pterocarpi indici 5

Herpetospermum caudigerum Wall. 5 Radix Aucklandiae (Radix Vladimiriae) 5

Semen Myristicae 5 Flos Caryophyllis 5

Herba Swertiae bimaculatae 10 Concretio Silicea Bambusaes 5

Flos Carthami 10 Stigma Crocis 0.5

Flos Bombacis Malabarici 5 Parmelia saxatilis Ach. 5

Rhizoma Drynariae 5 Herba Ephedraes 2.5

ZUOTAI 2.5 Semen Alpiniae Katsumadai 5

Fructus Chebulae 10 Cortex Cinnamomis 15

Corydalisimpatiens(Pall.)Fisch 5 artificial Calculus Boviss 5

Flos meconopsis quintuplinerviae 10 Tangut aconite 15

Fructus Terminaliae Billericae 5 Moschus 0.04

Radix Inulae 10.

2, Tibetan medicine according to claim 1, its feature also is: described Fructus Chebulae and Fructus Terminaliae Billericae have been the Fructus Chebulae and the Fructus Terminaliae Billericae of nuclear.

3, a kind of preparation method for the treatment of the Tibetan medicine of hepatopathy according to claim 1, its feature also is: the preparation method that above-mentioned each component is made medicine of the present invention is:

1. famous and precious thin medical material ZUOTAI, Calculus Bovis, Stigma Croci, Moschus are developed into fine powder respectively, standby,

2. will become fine powder except that all the other pulverizing medicinal materials the above-mentioned famous and precious thin medicine, sieve,

3. add ZUOTAI, Calculus Bovis, Stigma Croci, Moschus fine powder facing-up, mixing,

4. add Mumiyah-asil, add water pill,

5. dry, to water content≤9.0%,

6. coating, polishing, quality examination, finished product packing, the stock promptly gets a kind of Tibetan medicine for the treatment of hepatopathy of the present invention.