CN102335416B - Compound Chinese medicinal composition for treating hog cholera and preparation method thereof - Google Patents

Abstract

The invention discloses a compound Chinese medicinal composition for treating hog cholera and a preparation method thereof, relating to the field of animal medicines. The preparation method comprises the following steps of: (1) sieving all components (except interferon) in the prescription with a 500-mesh sieve after ultra-fine pulverization; (2) taking 15-25 parts of propolis, 3-10 parts of interferon for pigs, 10-25 parts of Cyrtomium fortune and 15-25 parts of selfheal according to weight part and mixing for 5-10 minutes until well mixing; (3) taking 10-20 parts of gypsum, 10-250 parts of dandelion, 10-25 parts of rhizoma anemarrhenae and 15-30 parts of rhubarb according to weight part and mixing for 5-10 minutes until well mixing; (4) combining the compositions prepared in the steps (2) and (3), continuing to mix for 10-15 minutes until well mixing. The invention has the beneficial effects of rational prescription and simple preparation; the composite has the advantages of no toxic effect, no pollution, no drug residue and no drug resistance, ultra-micro pulverization, high bioavailability, obvious curative effect and special effect for treating hog cholera through the clinical evidence.

Description

A kind of herbal mixture composition and method of making the same for the treatment of swine fever

Technical field

The present invention relates to animal medicine and preparation method field, particularly a kind of herbal mixture composition and method of making the same for the treatment of swine fever.

Background technology

Swine fever is caused by swine fever virus a kind of acute, heating, contagious disease.There is hyperinfection and lethal.It is characterized in that: acute, be septic and change, the organa parenchymatosum is hemorrhage, necrosis and infarction; The chronic fiber disposition necrotic enteritis that is, often there are paratyphoid fever and Bacillus pasteurii disease secondary in the later stage.Primary disease is an infected pigs under field conditions (factors), and the pig of all ages and classes, sex, kind and wild boar be susceptible all, all can occur throughout the year.It is one of principal disease of harm pig industry.

The pathogen of primary disease is swine fever virus, and this disease spreads all over more or less a hundred country of five continents, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral agents ban use of as Ministry of Agriculture such as ribavirin, amantadines.

Therefore research and develop and a kind ofly treat the drug residue free of swine fever, the specific medicament produced that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the herbal mixture composition and method of making the same of effective treatment swine fever of drug residue.

Implementation of the present invention is as follows for achieving the above object: a kind of herbal mixture compositions for the treatment of swine fever, by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part.

Described various component optimum ratio amount is: 20 parts of propolis, 5 parts of interferon, 20 parts of Rhizoma Osmundae, 20 parts of Spica Prunellaes, 15 parts, Gypsum Fibrosum, 20 parts of Herba Taraxacis, 20 parts of the Rhizoma Anemarrhenaes, 25 parts of Radix Et Rhizoma Rhei for pig.

A kind of preparation method for the treatment of the herbal mixture compositions of swine fever, carry out as follows:

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-25 part, pig with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, mix 5-10 minute to even;

(3) take by weight Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, there is the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had to inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Rhizoma Osmundae: hot, bitter, cold, return lung, liver, stomach warp, there is the function of heat-clearing and toxic substances removing, cooling blood for hemostasis; Cure mainly pestilence, pharyngeal swelling, sore swollen toxin, floating pulse, pathopyretic ulcer etc.

Spica Prunellae: bitter, cold, hot, return liver, gallbladder meridian, there is the function of purging liver-fire, improving eyesight, mass dissipating and swelling eliminating, diuresis; Cure mainly pestilence, conjunctival congestion and swelling pain, acute mastitis, skin ulcer swollen etc.

Herba Taraxaci: bitter, sweet, cold, return liver, stomach warp, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; Cure mainly sore, lung abscess, pharyngalgia, jaundice due to damp-heat, pyretic stranguria.

Gypsum Fibrosum: sweet, hot, Great Cold, attach to the lung and stomach meridians, there is the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, high fever coma etc.

The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, there is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, yin asthenia generating intrinsic heat etc.

Radix Et Rhizoma Rhei: bitter, cold, return spleen, stomach, large intestine, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass clots absorbing; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain etc.

Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of swine fever, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven flavors Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, the treatment swine fever is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of herbal mixture composition and method of making the same for the treatment of swine fever: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 30 parts of interferon, 100 parts of Rhizoma Osmundae, 150 parts of Spica Prunellaes for pig, mix 5-10 minute to evenly;

(3) take by weight 100 parts, Gypsum Fibrosum, 100 parts of Herba Taraxacis, 100 parts of the Rhizoma Anemarrhenaes, 150 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of swine fever and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight 200 parts of propolis, 50 parts of interferon, 150 parts of Rhizoma Osmundae, 200 parts of Spica Prunellaes for pig, mix 5-10 minute to evenly;

(3) take by weight 150 parts, Gypsum Fibrosum, 150 parts of Herba Taraxacis, 150 parts of the Rhizoma Anemarrhenaes, 200 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of swine fever and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 100 parts of interferon, 250 parts of Rhizoma Osmundae, 250 parts of Spica Prunellaes for pig, mix 5-10 minute to evenly;

(3) take by weight 200 parts, Gypsum Fibrosum, 250 parts of Herba Taraxacis, 250 parts of the Rhizoma Anemarrhenaes, 300 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 200kg feeds, and drinking-water 450kg, every day 2-3 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment swine fever:

Compile	Group	Dead	Cure	Symptom is arranged during end
					I	The blank group	10.5	74.6	14.9
II	The swine fever health group of faling apart	7.2	80.6	12.2
					III	Chinese medicine composition of the present invention	5.1	87.6	7.3

This clinical effectiveness statistical analysis, present composition treatment group is being compared significant difference (P<0.05) with the loose group of swine fever health aspect cure rate.

Above-mentioned detailed description of pure Chinese medicine composition of this treatment swine fever and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. a herbal mixture compositions for the treatment of swine fever, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part.

2. a kind of herbal mixture compositions for the treatment of swine fever according to claim 1, is characterized in that described various component optimum ratio amount is: 20 parts of propolis, 5 parts of interferon, 20 parts of Rhizoma Osmundae, 20 parts of Spica Prunellaes, 15 parts, Gypsum Fibrosum, 20 parts of Herba Taraxacis, 20 parts of the Rhizoma Anemarrhenaes, 25 parts of Radix Et Rhizoma Rhei for pig.

3. the preparation method of the herbal mixture compositions of a treatment swine fever according to claim 1 is characterized in that carrying out as follows:

(1) the various compositions except interferon in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-25 part, pig with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, mix 5-10 minute to even;

(3) take by weight Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.