CN1279888A

CN1279888A - Hand washing and sterilizing agent

Info

Publication number: CN1279888A
Application number: CN 99113854
Authority: CN
Inventors: 孙忠; 罗鑫龙; 周鸣方
Original assignee: SHANGHAI WHITE CAT CO Ltd
Current assignee: Shanghai Whitecat Shareholding Co., Ltd.
Priority date: 1999-07-07
Filing date: 1999-07-07
Publication date: 2001-01-17
Anticipated expiration: 2019-07-07
Also published as: CN1156215C

Abstract

Technologically the presentinvention features that a hand sterilizing agent is prepared by mixing organic chloride and low-carbon chain alcohol as disinfector, cellulose, acrylic acid and cationic polymer as densifier, potassium salt, sodium salt, ammonium salt, alcohol amine, etc. as neutralizer, moisture maintaining agent and water. When small amount of the sterilizing agent is applied to hands homogeneously through rubbing and after being volatized, it can kill 99.99% of bacteria in hands and has certain destruction to hepatitis B HBsAg. It is superior to common hand washing sterilizing liquid in that its application needs no water carrier, and this can prevent cross infection and bacteria propagation.

Description

The sterilization detergent for cleaning hand

The present invention relates to the chemical products field, especially a kind of hand disinfectant.

At present, hand disinfectant commonly used in the daily life is the disinfection hand cleanser of liquid type, and mainly adopting surfactant, disinfectant, thickener, solvent, water is primary raw material.This series products is mainly used in the washroom in family, hotel, uses in the process of washing one's hands, and must wash by water after using, so its use occasion has limited its scope of application.

The object of the present invention is to provide a kind of Disinfection Effect good, good hand touch portably uses conveniently, does not need the sterilization detergent for cleaning hand of water.

Technical scheme of the present invention is: according to the occupation mode of product, the disinfectant of selecting for use and other auxiliary agent use the back in that residue is the least possible on hand, and residue does not influence feel.According to the sterilization requirement of this product, select suitable disinfectant and working concentration, reach the purpose of quick kill bacteria and destruction antigen of hepatitis B virus.Outward appearance according to product reaches transparent gel shape colloid and uses the requirement of back to feel, selects suitable thickening, neutralizer, humectant.

Its concrete technical scheme is to adopt following raw material and weight percent concentration thereof:

A: alcohol disinfectant 30-90%, it can be that low carbon chain alcohol can be ethanol or propyl alcohol or isopropyl alcohol.

B: chlorine class disinfectant: 0.1-5%, it can be chlorobenzene phenols or chlorobenzene ethers or its two mixture, as PCMX 2-hydroxyl-4, ' 2 ', 4 '-three chlorodiphenyl ethers, 2,6 one dimethyl-4-hydroxyl chlorobenzene, clorox.

C: animals and plants thickener: 0.1-5%, adopt cellulose family, acrylic compounds, cationic polymer, they can be: the Ka Baibo acrylic resin.

D: neutralizer 0.1-5%, can be hydroxide potassium, sodium ammonium salt or monoethanolamine ,=monoethanolamine, triethanolamine.

E: humectant: 0.5-5% adopts polyalcohol, as medicinal glycerin.

F: deionized water: surplus

By having adopted alcohols, chlorine class disinfectant among the present invention, make its disinfective action strong, again owing to contain thickener, neutralizer, humectant in the product of the present invention, and one time usage amount is few, the overwhelming majority becomes the effumability material in the prescription, most of component vapors away in the use, and the residue of staying after the use on hand is micro-, and residue is nontoxic.Therefore this product can be crossed water after using, and the adversary does not injure, and can play the effect of preserving moisture on the contrary.

Product of the present invention has stronger disinfective action after testing and did not need the effect of water handguard, and concrete data are as follows:

1, to the killing rate of Pseudomonas aeruginosa (ATCC2027)

Concentration (%)	Difference (min) killing rate % action time
	Difference (min) killing rate % action time				1	2	5	10
100	100	100	100	100
20	99．65	99．70	99．80	99．83

Annotate: contrast bacterium number is 1.5 * 10 ⁶Cfu/ml2, to killing rate from look candida albicans (ATCCl272)

Concentration (%)	Difference (min) killing rate % action time
	Difference (min) killing rate % action time				1	2	5	10
100	100	100	100	100
20	99．99	99．999	100	100

Annotate: contrast bacterium number is 2.9 * 10 ⁶Cfu/ml3, to the killing rate of Escherichia coli (8099)

Concentration (%)	Difference (min) killing rate % action time
	Difference (min) killing rate % action time				1	2	5	10
100	100	100	100	100
20	99．92	99．94	99．98	99．999

Annotate: the contrast bacterium counts 2.8cfu/ml4, to the killing rate of staphylococcus aureus (ATCC6538)

Annotate: contrast bacterium number is 1.6 * 10 ⁶Cfu/ml

5, HbsAg failure test: the concentration of purifying HBxAg is the 10ug/ml neutralizer: 0.5% sodium thiosulfate+2% Tween-80+0.5% lecithin is to the HbsAg destruction:

Concentration (%)	No	Same-action time (min) OD value
Concentration (%)	No	Same-action time (min) OD value				????3	????5	????7	????10
????100	0．060(+)	0．053(+)	0．045(-)	0．041(-)		????3	????5	????7	????10
????100	0．060(+)	0．053(+)	0．045(-)	0．041(-)	????20	0．518(+)	0．471(+)	0．303(+)	0．183(+)

Negative control OD value 0.022 positive control OD value 0.286 sensitivity 1ng/ml

Good from the visible properties of product of the present invention of above-mentioned data.

Set forth most preferred embodiment of the present invention below:

Implementation column one:

A: ethanol 60%

B: PCMX 0.5%

C: card uncle ripple 941 resins 2%

D: sodium hydroxide 2%

E: medicinal glycerin 5%

F: deionized water surplus

Get final product after above-mentioned thing sample fully mixed.

Embodiment two:

A: isopropyl alcohol 50%

B:2-hydroxyl-4,2 ', 4 ' 1 chlorodiphenyl ethers 1%

C: card uncle ripple 940 resins 3%

D: triethanolamine 1%

E: medicinal glycerin 3%

F: deionized water surplus

Above-mentioned thing sample fully mixed to mix get final product after stirring.

Embodiment three:

A: propyl alcohol 70%

B:2,6-dimethyl-4-hydroxyl chlorobenzene 1.2%

C: card uncle ripple 934 resin fat 3%

D: monoethanolamine 2%

E: the medicinal glycerin chamber is sliding transfers 4%

F: deionized water surplus

Above-mentioned thing sample mixing is fully got final product after the stirring.

Claims

1, a kind of hand skin disinfectant is characterized in that its formulation weight percentage proportioning is:

A, alcohol disinfectant 30-90%;

B, the chlorine class neat 0.1-5% that sterilizes;

C, thickener 0.1-5%;

D, neutralizer 0.1-5%;

E, humectant adopt polyalcohol 0.5-5%;

F, surplus deionized water:

2, according to claim 1 described a kind of sterilization detergent for cleaning hand, it is characterized in that alcohol disinfectant can be a low carbon chain alcohol, this low carbon chain alcohol can be ethanol or propyl alcohol or isopropyl alcohol.

3, according to claim 1 described a kind of sterilization detergent for cleaning hand, it is characterized in that chlorine class disinfectant can be with a kind of: PCMX, 2-hydroxyl-4,2 ', 4 '-three chlorodiphenyl ethers, 2,6-dimethyl-4-hydroxyl chlorobenzene, clorox.

4,, it is characterized in that thickener can be a Ka Baibo oleic series resin according to claim 1 described a kind of sterilization detergent for cleaning hand.

5, according to claim 1 described a kind of sterilization detergent for cleaning hand, it is characterized in that neutralizer can be following a kind of: the potassium of hydroxide, sodium, ammonium salt, monoethanolamine, diethanol amine, triethanolamine.

6, according to claim 1 described a kind of sterilization detergent for cleaning hand, it is characterized in that humectant, polyalcohol can be a medicinal glycerin.