CN1272066C - Medicinal composition for relieving itching - Google Patents
Medicinal composition for relieving itching Download PDFInfo
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- CN1272066C CN1272066C CN 200410012128 CN200410012128A CN1272066C CN 1272066 C CN1272066 C CN 1272066C CN 200410012128 CN200410012128 CN 200410012128 CN 200410012128 A CN200410012128 A CN 200410012128A CN 1272066 C CN1272066 C CN 1272066C
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- rhizoma
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- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 208000003251 Pruritus Diseases 0.000 title abstract description 14
- 230000007803 itching Effects 0.000 title description 3
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000003908 antipruritic agent Substances 0.000 claims description 8
- 241000206501 Actaea <angiosperm> Species 0.000 claims description 2
- 241000931705 Cicada Species 0.000 claims description 2
- 241000628997 Flos Species 0.000 claims description 2
- 241000555682 Forsythia x intermedia Species 0.000 claims description 2
- 241000245240 Lonicera Species 0.000 claims description 2
- 241000219780 Pueraria Species 0.000 claims description 2
- 241001180876 Saposhnikovia Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 239000002775 capsule Substances 0.000 abstract description 11
- 238000012360 testing method Methods 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 241000906579 Actaea cimicifuga Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000050051 Chelone glabra Species 0.000 abstract 1
- 241000229179 Ledebouriella Species 0.000 abstract 1
- 206010067482 No adverse event Diseases 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 235000005301 cimicifuga racemosa Nutrition 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 230000002110 toxicologic effect Effects 0.000 abstract 1
- 231100000027 toxicology Toxicity 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 12
- 229940079593 drug Drugs 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 230000001154 acute effect Effects 0.000 description 4
- 230000001139 anti-pruritic effect Effects 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 2
- 229960004494 calcium gluconate Drugs 0.000 description 2
- 235000013927 calcium gluconate Nutrition 0.000 description 2
- 239000004227 calcium gluconate Substances 0.000 description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 2
- 229960003291 chlorphenamine Drugs 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010052568 Urticaria chronic Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000024376 chronic urticaria Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960000785 fluocinonide Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a medicinal composition for relieving itch, which comprises the raw materials of the following proportion by weight: 6 to 9 portions of swordlike atractylodes rhizome, 6 to 9 portions of rhizome, 6 to 9 portions of largetrifoliolious bugbane rhizome, 6 to 9 portions of radix puerariae, 4 to 12 portions of baical skullcap root, 4 to 12 portions of amur cork-tree, 6 to 9 portions of weeping forsythiae capsule, 3 to 9 portions of red peony root, 6 to 12 portions of ledebouriella root and 1 to 4 portions of fresh ginger. The medical composition has the advantages of favorable effect on relieving itch, short curing time, obvious long-time therapeutic effect, short therapeutic period and no adverse reaction through the toxicological tests of animals and clinical application.
Description
Affiliated field
The present invention relates to pharmaceutical product, specifically a kind of antipruritic agent compositions that is applicable to skin pruritus.
Technical background
Skin pruritus is the common skin disease.Its cause of disease complexity is with all multifactor relevant.Chinese medicine thinks that the cause of disease of this disease and damp and hot ailment said due to cold or exposure are strongly fragrant in skin, endogenous cause of ill with insufficiency of the spleen, the wet positive QI-insufficiency of spleen is relevant.It is extra-to be generally shape, and old complaint is in the lining.Clinical application at present is a lot, and as fluocinonide, dexamethasone, chlorphenamine, diphenhydramine, calcium gluconate or the like, but effect is all undesirable, and particularly late result has much room for improvement especially.
Summary of the invention
Purpose of the present invention just provides the good antipruritic agent compositions of a kind of antipruritic effect.
The object of the present invention is achieved like this:
Antipruritic agent compositions provided by the present invention includes the following weight proportion raw material:
6～9 parts of Rhizoma Atractylodis, 6～9 parts of the Rhizoma Atractylodis Macrocephalaes, 6～9 parts of Rhizoma Cimicifugaes, 6～9 parts of Radix Puerariaes, 4～12 parts of Radix Scutellariaes, 4～12 parts of Cortex Phellodendris, 6～9 parts of Fructus Forsythiaes, 3～9 parts of Radix Paeoniae Rubra, 6～12 parts of Radix Saposhnikoviaes, 1～4 part in Rhizoma Zingiberis Recens.
Each component of medicine of the present invention is determined through testing repeatedly, screening, and behind each component compatibility, has produced good synergism.
Among the present invention, the effect of playing yang invigorating altogether, detoxify, inducing sweat is share in Rhizoma Cimicifugae yang invigorating expelling pathogenic factors from the exterior, detoxifcation with Radix Puerariae.Radix Paeoniae Rubra removing pathogenic heat from blood and toxic substance from the body, regulating and activating blood circulation; The Rhizoma Atractylodis Macrocephalae is drying damp and strengthening spleen, the diuretic dampness removing; Radix Scutellariae, Fructus Forsythiae heat-clearing and toxic substances removing; Radix Saposhnikoviae drives the ailment said due to cold or exposure of human body, can send out ailment said due to cold or exposure and go out from the hair key, and Rhizoma Zingiberis Recens can be conciliate all medicines, helps ailment said due to cold or exposure to go out and the effect of conciliating taste is arranged.All medicines share, and have three clear effects, i.e. the poison of a clear fur; Damp and hot poison in the two clear bodies; Three stasis of blood poison in purifying the blood.
Pharmaceutical composition of the present invention is monarch drug with the antipyretic, is ministerial drug with the invigorating spleen to remove dampness medicine, and the wet spleen that goes is strong, and it is adjuvant drug that wind dispelling is searched the network medicine, thereby reaches the purpose for the treatment of both the principal and secondary aspects of a disease.Because of its periphery of itching is wind, cold is arranged in the wind again, so separate in the wind cold with a small amount of guiding drug.
Compatibility of the present invention is precise and appropriate, drug effect obvious, the focus of can going directly, and has the effect of getting instant result.
For strengthening the effect of detoxifcation of the present invention, can in compositions, increase the following weight proportion raw material: 10～12 parts of Flos Loniceraes.
For further strengthening the effect of its dampness removing heat clearing away, can in compositions, increase the following weight proportion raw material: 30～45 parts of Rhizoma Smilacis Glabraes, 6～9 parts of Radix Sophorae Flavescentiss.
Also can in compositions, increase the following weight proportion raw material: 6～9 parts of Radix Angelicae Sinensis, 20～30 parts of the Fructus Kochiae, 6～9 parts of Periostracum Cicadaes.With further enhancing drug effect of the present invention.
Pharmaceutical composition of the present invention can be prepared into capsule, honeyed pill, decoction, oral liquid, also can be prepared into lotion and liniment.
The preparation method of medicament composition capsule of the present invention is:
After each medicine components oven dry of the present invention, take by weighing, sterilize, pulverized 80 mesh sieves by its weight proportion, mixing, in incapsulating, every capsules nearly weighs 0.5 gram.
Other dosage forms of pharmaceutical composition of the present invention all can be prepared by the conventional preparation method in the pharmaceutics.
Pharmaceutical composition of the present invention has that heat-clearing and toxic substances removing, removing heat from blood nourish blood, dampness removing blood stasis dispelling, the antipruritic effect of wind dispelling.
Can be used for treating acute and chronic urticaria, acute and chronic eczema, recurrent eczema, intractable eczema, acute and chronic dermatitis, vulva pruritus, skin itching diseases such as eczema scrotum.
Instructions of taking of the present invention is:
Capsule is taken 4～6 at every turn, every day three times.
Decoction every day three times, take at every turn and be equivalent to crude drug in whole 6～9 grams.
The other drug of can stopping using during the treatment, and can keep original diet and living habit constant.Acute stage,, chronic patients was to take capsule based on decoction or oral liquid.Be seven days a course of treatment, and the general lighter patient of symptom takes a course of treatment and can fully recover, and sick time is grown (more than half a year) and then need be taken 2～4 courses of treatment.
Pharmaceutical composition of the present invention has good antipruritic effect, and its healing time is short, and late result is definite, short treating period, and do not find untoward reaction through animal toxicology test and clinical practice.
Beneficial effect of the present invention is confirmed by following experiment.
Physical data
100 routine skin pruritus patients (age is at 8 years old～60 years old, and year does not wait disease time a few days～10, and the male patient accounts for 42%, and female patient accounts for 58%).All case is a primary symptom with part or whole skin pruritus all, with the red pimple of skin, welt or scratch.Wherein have 52% patient to use chlorphenamine, dexamethasone, calcium gluconate, but all effect is bad or have a relapse.
Therapeutic Method:
The patient of disease time within a few days takes course of treatment of capsule of the present invention (clean skin itching-relieving capsule, the i.e. made capsule of embodiment 1).Disease time is taken 2～4 courses of treatment of capsule of the present invention the patient more than ten days.
Curative effect judging standard:
Recovery from illness: no pruritus; Produce effects: pruritus once in a while, not medication do not influence the work and study life; Invalid: pruritus does not alleviate, and influences work and study.
Therapeutic outcome, recovery from illness accounts for 88%, produce effects 10%, total effective rate 98%, invalid 2%.
In the recovery from illness patient, 33 patients that come to go to a doctor because of having a relapse are arranged.This test has been carried out following up a case by regular visits in 5 years to the patient after fully recovering, and does not see recidivist again.
The specific embodiment
Embodiment 1
Take by weighing Rhizoma Atractylodis 6kg, Rhizoma Atractylodis Macrocephalae 6kg, Rhizoma Cimicifugae 9kg, Radix Puerariae 9kg, Radix Scutellariae 6kg, Cortex Phellodendri 6kg, Fructus Forsythiae 9kg, Radix Paeoniae Rubra 4.5kg, Radix Saposhnikoviae 9kg, Rhizoma Zingiberis Recens 1.5kg.
With above all medicines, oven dry, dry sterilization was pulverized 80 mesh sieves, and mix homogeneously incapsulates.Every capsules weighs 0.5 gram.
Following examples 2～5, its preparation method are with embodiment 1, and just component and proportioning weight are different, but all can realize effect of the present invention.
Claims (4)
1, a kind of antipruritic agent compositions is characterized in that it includes the following weight proportion raw material:
6～9 parts of Rhizoma Atractylodis, 6～9 parts of the Rhizoma Atractylodis Macrocephalaes, 6～9 parts of Rhizoma Cimicifugaes, 6～9 parts of Radix Puerariaes, 4～12 parts of Radix Scutellariaes, 4～12 parts of Cortex Phellodendris, 6～9 parts of Fructus Forsythiaes, 3～9 parts of Radix Paeoniae Rubra, 6～12 parts of Radix Saposhnikoviaes, 1～4 part in Rhizoma Zingiberis Recens.
2, antipruritic agent compositions according to claim 1 is characterized in that it also has the following weight proportion raw material: 10～12 parts of Flos Loniceraes.
3, antipruritic agent compositions according to claim 1 is characterized in that it also includes the following weight proportion raw material: 30～45 parts of Rhizoma Smilacis Glabraes, 6～9 parts of Radix Sophorae Flavescentiss.
4, antipruritic agent compositions according to claim 3 is characterized in that it also has the following weight proportion raw material: 6～9 parts of Radix Angelicae Sinensis, 20～30 parts of the Fructus Kochiae, 6～9 parts of Periostracum Cicadaes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012128 CN1272066C (en) | 2004-01-18 | 2004-01-18 | Medicinal composition for relieving itching |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012128 CN1272066C (en) | 2004-01-18 | 2004-01-18 | Medicinal composition for relieving itching |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1640451A CN1640451A (en) | 2005-07-20 |
| CN1272066C true CN1272066C (en) | 2006-08-30 |
Family
ID=34867780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410012128 Expired - Fee Related CN1272066C (en) | 2004-01-18 | 2004-01-18 | Medicinal composition for relieving itching |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1272066C (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491575B (en) * | 2008-12-18 | 2012-04-25 | 浙江省中医院 | Traditional Chinese medicine extract for treating atopic dermatitis and granules thereof |
| CN102488851B (en) * | 2011-12-28 | 2013-08-21 | 张志远 | Drug for treating recurrent genital herpes and preparation method thereof |
| CN102973674B (en) * | 2012-11-22 | 2014-08-13 | 张继成 | Eczema eliminating capsule |
| CN103202979A (en) * | 2013-03-04 | 2013-07-17 | 余金标 | Powder for treatment of scrotal eczema by using cascara Sagrada |
| CN103784588B (en) * | 2014-01-22 | 2016-09-28 | 陈天丽 | A kind of Chinese drugs agentia treating seborrheic dermatitis and preparation method |
| CN104208535A (en) * | 2014-09-29 | 2014-12-17 | 张晨 | Externally applied ointment for treating eczema |
| CN104857419A (en) * | 2015-05-18 | 2015-08-26 | 黄克会 | Medicine for treating pruritus inside and outside private parts of men and women |
| CN105267799A (en) * | 2015-11-16 | 2016-01-27 | 吴斌 | Medicine for treating chronic eczema |
| CN105770655A (en) * | 2016-04-24 | 2016-07-20 | 邹洪胜 | Traditional Chinese medicine composition for treating scroti eczema |
| CN105878811A (en) * | 2016-06-17 | 2016-08-24 | 杜威 | External-use traditional Chinese medicine for treating rubella itching |
-
2004
- 2004-01-18 CN CN 200410012128 patent/CN1272066C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1640451A (en) | 2005-07-20 |
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