CN116211946B

CN116211946B - Application of traditional Chinese medicine composition in preparation of medicine for promoting fracture healing

Info

Publication number: CN116211946B
Application number: CN202310285949.XA
Authority: CN
Inventors: 杨丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2023-03-22
Filing date: 2023-03-22
Publication date: 2023-09-26
Anticipated expiration: 2043-03-22
Also published as: CN116211946A

Abstract

The application relates to the technical field of traditional Chinese medicine compositions, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for promoting fracture healing, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20-25 parts of teasel root, 15-20 parts of achyranthes root, 15-20 parts of myrrh, 10-15 parts of dogwood, 15-20 parts of drynaria rhizome, 10-20 parts of red sage root, 10-15 parts of dried rehmannia root, 10-15 parts of cortex moutan, 5-15 parts of pinellia tuber and 5-10 parts of ledebouriella root. In the application, teasel root, radix dipsaci, which are monarch drugs, are used for regulating blood and dredging collaterals, strengthening bones and muscles, and activating blood and dredging channels; myrrh has the effects of activating blood circulation to relieve pain, relieving swelling and promoting granulation, dogwood has the effects of nourishing liver and kidney, promoting blood circulation, relieving swelling, rhizoma drynariae to strengthen bones, tonifying kidney, dispelling wind-damp, activating blood circulation to relieve pain, and the three are ministerial drugs; the salvia miltiorrhiza has the effects of promoting blood circulation to remove blood stasis, clearing away blood heat, promoting the production of body fluid, cooling blood to stop bleeding, the cortex moutan has the effects of clearing deficiency heat, and the processed cornus officinalis has the effect of warming and astringing, and the three are adjuvant drugs, and the pinellia ternate and the radix sileris are combined as guiding drugs. The medicines are mutually combined to play roles of promoting blood circulation, removing blood stasis, relieving swelling and pain, strengthening bones and muscles, promoting poroma growth and accelerating healing of fracture parts of patients.

Description

Application of traditional Chinese medicine composition in preparation of medicine for promoting fracture healing

Technical Field

The application relates to the technical field of traditional Chinese medicine compositions, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for promoting fracture healing.

Background

Fracture refers to a break in the integrity or continuity of a bone. Fractures occur when bones are subjected to forces exceeding the maximum strength they can withstand. The clinical manifestations are that after trauma, symptoms such as pain, swelling, movement disorder and the like appear locally, and bone deformity, abnormal movement and bone abrasion sound (sensation) are special signs of fracture.

At present, a patient after fracture is generally fixed by beating gypsum or splints, the patient is firstly subjected to operation treatment and then reinforced with gypsum, the fracture is required to be fixed in a reduction way, no matter the internal fixation of operation treatment or the external fixation of conservative treatment, the better the fracture alignment is, the smaller the fracture gap is, the easier the fracture is healed, and the key point of fracture recovery is that the healing of fracture parts occurs; in general, a fracture patient needs more than three months to half a year to recover, delays the patient for a lot of time, and brings adverse effects to the work and life of the patient, so accelerating the healing of the fracture part is still a very important problem in the medical field. At present, the patients generally adopt traumatic injury medicaments such as Yunnan white drug powder capsules, pseudo-ginseng tablets and the like, the damage to liver function or kidney function can be caused after long-term administration, and the patients with abnormal liver and kidney functions are forbidden, so that a series of sequelae are easy to cause.

Disclosure of Invention

The application aims to overcome the defects in the prior art and provides application of a traditional Chinese medicine composition in preparation of a medicine for promoting fracture healing.

The application provides application of a traditional Chinese medicine composition in preparation of a medicine for promoting fracture healing, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-25 parts of teasel root, 15-20 parts of achyranthes root, 15-20 parts of myrrh, 10-15 parts of dogwood, 15-20 parts of drynaria rhizome, 10-20 parts of red sage root, 10-15 parts of dried rehmannia root, 10-15 parts of cortex moutan, 5-15 parts of pinellia tuber and 5-10 parts of ledebouriella root.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-23 parts of teasel root, 15-18 parts of achyranthes root, 15-18 parts of myrrh, 10-13 parts of dogwood, 15-18 parts of drynaria rhizome, 10-16 parts of red sage root, 10-13 parts of dried rehmannia root, 10-13 parts of cortex moutan, 5-11 parts of pinellia tuber and 5-8 parts of ledebouriella root.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 23 parts of teasel root, 18 parts of achyranthes root, 18 parts of myrrh, 13 parts of dogwood, 18 parts of drynaria rhizome, 16 parts of red sage root, 13 parts of dried rehmannia root, 13 parts of cortex moutan, 11 parts of pinellia tuber and 8 parts of ledebouriella root.

Preferably, the composition is an extract obtained by mixing and decocting the above raw materials according to the proportion.

Preferably, the traditional Chinese medicine composition is prepared by the following method: weighing the medicinal materials according to the weight ratio, soaking the medicinal materials in water for 2 hours, adding 10 times of water for 2 times of decoction, each time for 60 minutes, and combining the extracts of the two times.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-23 parts of radix dipsaci extract, 15-18 parts of achyranthes bidentata extract, 15-18 parts of myrrh extract, 10-13 parts of dogwood extract, 15-18 parts of drynaria extract, 10-16 parts of red sage root extract, 10-13 parts of radix rehmanniae extract, 10-13 parts of cortex moutan extract, 5-11 parts of pinellia tuber extract and 5-8 parts of radix saposhnikoviae extract.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 23 parts of radix dipsaci extract, 18 parts of achyranthes root extract, 18 parts of myrrh extract, 13 parts of dogwood extract, 18 parts of drynaria rhizome extract, 16 parts of red sage root extract, 13 parts of dried rehmannia root extract, 13 parts of cortex moutan extract, 11 parts of pinellia tuber extract and 8 parts of ledebouriella root extract.

The types and mechanisms of the medicines in the application are as follows:

teasel root, chinese medicine name. Is dry root of Dipsacus asperus asper wall. Ex Henry of Dipsacus of Dipsacaceae. Has effects of invigorating liver and kidney, strengthening tendons and bones, and promoting blood circulation.

Achyranthes root and its Chinese medicine name. Is root of Achyranthes bidentata (Achyranthes bidentata) belonging to genus Achyranthes of family Amaranthaceae and Achyranthes (Achyranthes bidentata) Cyathula officinalis Kuan belonging to genus Achyranthes. Has effects of promoting blood circulation, dredging channels, nourishing liver and kidney, strengthening tendons and bones, promoting diuresis, relieving stranguria, and inducing fire (blood) to descend.

Myrrh and Chinese medicine. Is oleoresin exuded from the bark of myrrh tree Commiphora myrrha Engl of Commiphora of Burseraceae, or other plants of the same genus. Has effects of promoting blood circulation, relieving pain, relieving swelling, and promoting granulation.

Fructus Corni, and traditional Chinese medicine. Is dried mature pulp of cornel Cornus officinalis Sieb.et Zucc. Has effects of invigorating liver and kidney, astringing, and inducing astringency.

Rhizoma Drynariae, and Chinese medicinal materials. Is rhizome of dryopteris crassifolia Drynaria fortunei (Kunze) J.Sm. Has effects of promoting blood circulation, promoting wound healing, invigorating kidney and strengthening bone.

Red sage root, the name of Chinese medicine. Is dry root and rhizome of Salvia Miltiorrhiza Salvia miltiorrhiza bge of Salvia of Labiatae. Has effects of promoting blood circulation, regulating menstruation, removing blood stasis, relieving pain, cooling blood, resolving carbuncle, relieving restlessness and tranquilizing.

Radix rehmanniae refers generally to the name of rehmannia root, chinese traditional medicine. Fresh or dried root tuber of rehmannia glutinosa Rehm, aniaglutinososis Libosch of Scrophulariaceae, clear heat and promote salivation, cool blood and stop bleeding, fresh radix rehmanniae is adopted in the application.

Cortex moutan, also called moutan bark, is known as Chinese medicine. Is dry root bark of Paeonia suffruticosa Paeonia suffruticosa Andr. Has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis.

Pinellia tuber, rhizoma Pinelliae, chinese medicine name. Is a dry tuber of the plant Pinellia ternata (thunder.) of Araceae, and has effects of eliminating dampness and phlegm, lowering adverse qi, relieving vomiting, and relieving stuffiness and resolving hard mass.

Radix Saposhnikoviae, and Chinese medicinal herbs. Is root of Ledebouriella plant of Ledebouriella of Umbelliferae Saposhnikovia divaricata (Turcz.) Schischk. Has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm.

Advantageous effects of the applicationEffects of

The formula of the application takes the formula principles of promoting blood circulation to remove blood stasis, relieving swelling and pain, strengthening bones and muscles and promoting callus growth, wherein teasel root regulates blood circulation to promote blood circulation, strengthens bones and muscles, and sets meridians, achyranthes root promotes blood circulation to promote menstruation, and the two are monarch drugs; myrrh has the effects of activating blood circulation to relieve pain, relieving swelling and promoting granulation, dogwood has the effects of nourishing liver and kidney, promoting blood circulation, relieving swelling, rhizoma drynariae to strengthen bones, tonifying kidney, dispelling wind-damp, activating blood circulation to relieve pain, and the three are ministerial drugs; the salvia miltiorrhiza has the effects of promoting blood circulation to remove blood stasis, clearing blood heat, promoting the production of body fluid, cooling blood to stop bleeding, the cortex moutan has the effects of clearing away deficiency heat, and the processed cornus officinalis has the effects of warming and astringing, and the three are adjuvant drugs, and the pinellia tuber has the effects of relieving distension and fullness, resolving masses, clearing heat and detoxicating, preventing wind, dispelling wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm and detoxifying, and the three are guiding drugs. The medicines are mutually combined to play roles of promoting blood circulation, removing blood stasis, relieving swelling and pain, strengthening bones and muscles, promoting poroma growth and accelerating healing of fracture parts of patients.

Detailed Description

It is noted that the following detailed description is exemplary and is intended to provide further explanation of the application, as all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs unless otherwise indicated. It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application.

The technical solutions of the present application will be clearly and completely described in connection with the embodiments, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

Example 1

Raw materials: 23g of teasel root, 18g of achyranthes root, 18g of myrrh, 13g of dogwood, 18g of drynaria rhizome, 16g of red sage root, 13g of dried rehmannia root, 13g of cortex moutan, 11g of pinellia tuber and 8g of divaricate saposhnikovia root.

The preparation method comprises the following steps: weighing the medicinal materials according to the weight ratio, soaking the medicinal materials in water for 2 hours, adding 10 times of water for 2 times, each time for 60 minutes, and combining the extracts of the two times.

Example 2

Raw materials: 25g of teasel root, 20g of achyranthes root, 20g of myrrh, 15g of dogwood, 20g of drynaria rhizome, 20g of red sage root, 15g of dried rehmannia root, 15g of cortex moutan, 15g of pinellia tuber and 10g of divaricate saposhnikovia root.

The preparation method is the same as in example 1

Example 3

Raw materials: 20g, achyranthes root 15g, myrrh 15g, dogwood 10g, drynaria 15g, red sage root 10g, dried rehmannia root 10g, tree peony bark 10g, pinellia tuber 5g and ledebouriella root 5g.

The preparation method is the same as in example 1

Example 4

Raw materials: 23g of radix dipsaci extract, 18g of achyranthes root extract, 18g of myrrh extract, 13g of dogwood extract, 18g of drynaria extract, 16g of red sage root extract, 13g of dried rehmannia root extract, 13g of cortex moutan extract, 11g of pinellia tuber extract and 8g of ledebouriella root extract.

Example 5

Raw materials: 20g of radix dipsaci extract, 15g of achyranthes root extract, 15g of myrrh extract, 10g of dogwood extract, 15g of drynaria extract, 10g of red sage root extract, 10g of dried rehmannia root extract, 10g of cortex moutan extract, 5g of pinellia tuber extract and 5g of ledebouriella root extract.

Treatment criteria:

and (3) healing: based on the X-ray image, the fracture line is blurred or invisible, continuous callus passes through the fracture line, swelling pain disappears, local pain is not caused, and the patient can move freely;

the method is effective: the symptoms and signs are obviously reduced, the functions are obviously improved, the activities are slightly limited, the porosis is obvious, the swelling and pain feeling is eliminated, and the patients can locally move;

invalidation: the symptoms have no change in sign, no poroma formation or little poroma formation, and obvious swelling and pain.

Experimental group

80 patients with ages of 20-60 years old (58 people with ages of 20-50 years old and 22 people with ages of 51-60 years old) firstly adopt the traditional Chinese medicine bone setting technique to reset the dislocated fracture, fix splint or gypsum externally, take the medicine prepared in the example 1 three times a day for 1 course of treatment, take 2-4 courses of treatment for ten days, and increase the serious patients to 5-6 courses of treatment.

Clinical results were observed after two months:

68 cases (85.00%) were cured, 9 cases (11.25%) were effective, 3 cases (3.75%) were ineffective, and the total effective rate was 96.25%.

Control group

Likewise 80 patients aged 20-60 years, 65 people 20-50 years old and 15 people 51-60 years old, drug selection: the patient adopts the fraxinus bone-setting capsule to treat, firstly adopts the traditional Chinese medicine bone setting technique to reset the dislocated fracture, and externally fixes the splint or gypsum, and continuously takes the capsule according to the standard quantity on the instruction.

Clinical results were observed after two months:

45 cases (56.25%) were cured, 24 cases (30.00%) were effective, 11 cases (13.75%) were ineffective, and the total effective rate was 86.25%.

In addition, as the treatment course of taking the medicine by some patients can be healed without two months, the recovery conditions of two groups of patients are counted, X-ray images are respectively carried out on the patients on the 20 th day, the 30 th day, the 45 th day and the 60 th day of taking the medicine, the recovery conditions are observed, and the sum of the recovery and the effective case number is counted at the time node respectively, so that the data are obtained as follows:

	day 20	For 30 days	45 days	For 60 days
					Experimental group	11 persons	32 people	67 persons	77 people
Control group	1 person	21 people	50 people	69 persons

It can be seen that the recovery rate of the experimental group patients was significantly greater than that of the control group patients.

Toxicity test:

mice were selected: male C57BL/6 mice, body weight 20-25 g,6 weeks old;

the extract prepared in example 1 was adjusted to the corresponding concentration according to the human-mouse dose-conversion factor 9. Firstly, raising a mouse in a proper environment for 2-3 days, then feeding the mouse with the extract with the adjusted concentration twice daily according to the frequency of 5-10ml each time for 3 weeks, ensuring that the mouse is at a temperature suitable for life during the test period, ensuring normal diet, and observing poisoning performance, weight, food intake and death condition of the mouse every day; results: the mice were normal after oral drenching, no abnormality occurred after 3 weeks, and then the mice were sacrificed and their viscera were dissected and examined, and no obvious abnormality was seen in each major viscera.

Comparative example 1

Raw materials: 23g of teasel root, 18g of achyranthes root, 18g of myrrh, 18g of drynaria rhizome, 16g of red sage root, 13g of dried rehmannia root and 8g of divaricate saposhnikovia root.

Typical cases:

mr, 43 years old, fertilizer factory workman, on the way to and from the class of riding electric motor car, owing to dodge a car, lead to heavily falling on the ground, right hand props the ground, later send the doctor, through doctor's diagnosis treatment for metacarpal fracture, wear splint and protective equipment and carry out the rest treatment, take the medicine of comparative example 1 preparation, respectively carried out X ray imaging on day 30 and day 45, the result of second imaging shows that the fracture line is fuzzy, has continuous callus to form, painful sense disappears, reach the standard that fully heals.

Mr. Zhao, the driving of the generation works, in riding the course of the small electric motor car evening, because the road light is darker and no obstacle of the road is observed, bump, then send the doctor, diagnose and treat to the humerus fracture through doctor, wear splint and protective equipment and carry on the rest treatment, take the medicament prepared in example 1, have carried on X-ray imaging on 20 th and 35 th day separately, the result of the second imaging shows the fracture line is fuzzy, there is continuous callus to form, the pain feel disappears, reach the above-mentioned standard that fully heals.

Comparative example 1 is one of the conditions before the inventor develops the component formula of the application, no dogwood, cortex moutan and pinellia tuber are added at that time, the taking effect is not expected by the inventor, a great amount of creative attempts and adjustment of the mechanism of the whole formula are carried out through the application, and mutual coordination and mutual restriction based on monarch, minister, assistant and guide in the formula are regulated, and after dogwood, cortex moutan and pinellia tuber are continuously added, the traditional medicine is synergistic, so that the medicine effect of the whole formula is greatly improved.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the application has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the application.

Claims

1. The application of the traditional Chinese medicine composition in preparing the medicine for promoting fracture healing is characterized by comprising the following raw material medicines in parts by weight: 20-25 parts of teasel root, 15-20 parts of achyranthes root, 15-20 parts of myrrh, 10-15 parts of dogwood, 15-20 parts of drynaria rhizome, 10-20 parts of red sage root, 10-15 parts of dried rehmannia root, 10-15 parts of cortex moutan, 5-15 parts of pinellia tuber and 5-10 parts of ledebouriella root.

2. The use according to claim 1, wherein the Chinese medicinal composition comprises the following raw materials in parts by weight: 20-23 parts of teasel root, 15-18 parts of achyranthes root, 15-18 parts of myrrh, 10-13 parts of dogwood, 15-18 parts of drynaria rhizome, 10-16 parts of red sage root, 10-13 parts of dried rehmannia root, 10-13 parts of cortex moutan, 5-11 parts of pinellia tuber and 5-8 parts of ledebouriella root.

3. The use according to claim 2, wherein the Chinese medicinal composition comprises the following raw materials in parts by weight: 23 parts of teasel root, 18 parts of achyranthes root, 18 parts of myrrh, 13 parts of dogwood, 18 parts of drynaria rhizome, 16 parts of red sage root, 13 parts of dried rehmannia root, 13 parts of cortex moutan, 11 parts of pinellia tuber and 8 parts of ledebouriella root.

4. The use according to any one of claims 1 to 3, wherein the Chinese medicinal composition is prepared by the following method: weighing the medicinal materials according to the weight ratio, soaking the medicinal materials in water for 2 hours, adding 10 times of water for 2 times of decoction, each time for 60 minutes, and combining the extracts of the two times.