CN1272039C - Chinese patent medicine for treating apoplexy and its preparation method - Google Patents
Chinese patent medicine for treating apoplexy and its preparation method Download PDFInfo
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Abstract
The present invention relates to a Chinese patent medicine for treating apoplexy and its preparation method. The medicine is prepared by medical materials such as astragalus root, spatholobus stem, angelica, chuanxiong rhizome, earthworm, hirudo, batryticated silkworm, buthus martensi kirsch, and hooked uncaria. Compared with existing technology, the Chinese patent medicine provided in the invention has the function of benefiting vital and nourishing blood, dispersing pathogenic wind and resolving phlegm, promoting blood circulation and relaxing vein, and it is mainly adapted for the patient who has the vital deficiency and blood stasis, wind phlegm and blood stasis block pulse in (blood lack) palsy disease, especially adapted for the patient in recovering period; the product has no toxic effect, the medical material recipe is more accurate and refine, the selected preparation can facilitate cure requirement for different patients; the provided preparation method can be directly used for instructing production, the production technics is simple, and the product quality can be conveniently controlled.
Description
Technical field: the present invention relates to a kind of Chinese patent medicine that is used for the treatment of apoplexy and preparation method thereof, belong to the field of traditional Chinese medicine technology.
Background technology: apoplexy is one of common clinical, is 115.61/10 ten thousand according to the interrelated data statistics at China's apoplexy sickness rate, prevalence is 259.93/10 ten thousand, mortality rate is 81.33/10 ten thousand, and disability rate accounts for suffers from patient's about 60%, human body health in serious harm, is the listed modern difficult treatment of WHO.At present, doctor trained in Western medicine clinical treatment cerebrovascular disease mainly is the therapeutic alliance that relies on multiple medicine, though curative effect is very fast, human body is all had the untoward reaction and the side effect of certain degree.The Chinese patent communique discloses name, and to be called " a kind of medicine for the treatment of apoplexy ", application number be 98120544.5 patent application, and its prescription is 25 flavor medicines nearly, and curative effect and quality all are difficult to be guaranteed; The Chinese patent communique also discloses name, and to be called " a kind of Chinese medicinal capsule agent and method for making thereof that can be used for treating the apoplexy and the thoracic obstruction ", application number be 01128760.8 patent application, its prescription also reaches 16 flavor medicines, main disease to be treated not only has cerebrovascular disease, also has cardiovascular disease; The applicant had once submitted to application number to be on May 30th, 2003 to State Patent Office: 031342140, name is called " a kind of Chinese patent medicine that is used for the treatment of apoplexy "; This application has all solved the problem that prior art exists from the aspects such as control of the clinical effectiveness and the quality of production; But because at the beginning of application, many methods, technology and imperfection; Simultaneously can select, be prepared into the sort of suitable Chinese patent medicine preparation and indeterminate for use, not finish this invention fully.
Summary of the invention: the objective of the invention is to: a kind of Chinese patent medicine that is used for the treatment of apoplexy and preparation method thereof is provided.Medicine that this provides and preparation method are that the applicant proposes on the basis of improving former patent application technology, compare with original application, and the application has finished development, the selection of suitable Chinese patent medicine preparation; Determined the usage ratio of selected medical material more; Also worked out the preparation method of different formulation products; These methods can directly apply to the production of instructing enterprise; The present invention constitutes like this: the Chinese medicine preparation of treatment apoplexy, calculate according to components by weight percent, it mainly is prepared from by Radix Astragali 100-300 part, Caulis Spatholobi 50-150 part, Radix Angelicae Sinensis 30-80 part, Rhizoma Chuanxiong 10-40 part, Pheretima 40-120 part, Hirudo 40-120 part, Bombyx Batryticatus 10-40 part, Scorpio 10-30 part, Ramulus Uncariae Cum Uncis 10-40 part, Flos Carthami 10-40 part, Ramulus Cinnamomi 10-40 part, Radix Achyranthis Bidentatae 10-40 part.Concretely: it is prepared from by 200 parts of the Radixs Astragali, 100 parts of Caulis Spatholobis, 25 parts of Ramulus Cinnamomi, 25 parts of Rhizoma Chuanxiongs, 50 parts of Radix Angelicae Sinensis, 75 parts of Hirudos, 75 parts of Pheretimas, 25 parts of Bombyx Batryticatus, 17 parts of Scorpios, 25 parts of Ramulus Uncariae Cum Uncis, 25 parts on Flos Carthami, 25 parts of Radix Achyranthis Bidentataes and appropriate amount of auxiliary materials.Described adjuvant comprises according to the different dosage form of preparation: 5% hydroxypropyl cellulose and cane sugar powder etc.Preparation of the present invention comprises granule, capsule, tablet, drop pill, oral liquid, injection, slow releasing preparation, controlled release preparation etc.
Granule of the present invention can prepare like this: Hirudo, Pheretima, Bombyx Batryticatus, Scorpio four flavor cold drying, be ground into fine powder, and sieve, mixing, standby; Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis three flavors add water distillation and extraction volatile oil, filter, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; Medicinal residues decoct with water three times with all the other Radixs Astragali, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, the Radix Achyranthis Bidentatae five tastes, filter, and filtrate and above-mentioned filtrate merge, be condensed into clear paste, spray drying adds above-mentioned medical material fine powder and an amount of cane sugar powder, mixing, spray into volatile oil again, dry granulation sieves, granulate, the bag film-coat, promptly.
Capsule of the present invention can prepare like this: Hirudo, Pheretima, Bombyx Batryticatus, Scorpio four flavor cold drying, be ground into fine powder, and sieve, mixing, standby; Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis three flavors add water distillation and extraction volatile oil, filter, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; Add an amount of beta cyclodextrin and water grinding in the volatile oil, cold drying is ground into fine powder, sieves, and is standby; All the other Radixs Astragali, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, the Radix Achyranthis Bidentatae five tastes decoct with water (medicinal residues of carrying behind the oil add) three times when decocting for the second time, decoction liquor merges with above-mentioned filtrate, filtration, be condensed into clear paste, spray drying adds above-mentioned medical material fine powder, mixing is granulated, and sieves, cold drying, granulate adds an amount of clathrate, mixing, sieve, encapsulated, promptly.
Tablet of the present invention can prepare like this: Hirudo, Pheretima, Bombyx Batryticatus, Scorpio four flavor cold drying, be ground into fine powder, and sieve, mixing, standby; Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis three flavors add water distillation and extraction volatile oil, filter, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; All the other Radixs Astragali, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, the Radix Achyranthis Bidentatae five tastes decoct with water (medicinal residues of carrying behind the oil add) three times when decocting for the second time, decoction liquor merges with above-mentioned filtrate, filtration, be condensed into clear paste, spray drying adds above-mentioned medical material fine powder, mixing is granulated, and sieves, cold drying, granulate adds 5% hydroxypropyl cellulose, spray into volatile oil, mixing, tabletting, the bag film-coat, promptly.
Compared with prior art, Chinese patent medicine preparation provided by the invention has the effect of benefiting QI and nourishing blood, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation to remove obstruction in the collateral, mainly be applicable to the patient of the being seen syndrome of blood stasis due to qi deficiency of (ischemic) apoplexy apoplex involving the channels and collaterals, wind-phlegm obstruction of collaterals by blood stasis arteries and veins card, be particularly useful for convalescent patient, have no side effect, the medical material prescription that uses in the product is more accurate, concise, can make things convenient for dissimilar patients' treatment demand through the preparation of selecting; And the preparation method that provides can be directly used in, and guidance is produced, production technology is easy, and product quality is convenient to control, has overcome the problem that prior art exists, and has reached the purpose of invention.
Theory of Chinese medical science is thought: the refreshing machine of the outer caused brains of resistance of brain BI-syndrome involved the blood vessels or blood oozing from the body openings or subcuta neous tissue brain feeling pulse is impaired to be the basic pathogenesis feature of apoplexy, its primary symptom be coma, hemiplegia, aphasia or in silence, crooked mouth and tongue, hemianesthesia, apoplex involving the channels and collaterals does not then have coma or slight refreshing knowledge obstacle, and based on diseases such as hemiplegia.Investigation of clinical epidemiology data according to State Administration of Traditional Chinese Medicine's tcm emergency encephalopathy cooperative groups shows, the apoplex involving the channels and collaterals patient sees so that wind-phlegm blood stasis numbness resistance venation card more, assertive evidence can doublely see have a dizzy spell, patient's condition relaxes, thermal image not very, white and greasy fur is clinical manifestation characteristic.Apoplex involving the channels and collaterals patient convalescent period common syndrome of blood stasis due to qi deficiency, except that primary symptom, be feature with shortness of breath and fatigue, mouthful sialorrhea, from sweating, brothers' swelling.Primary disease is the main patient of sending out with the middle-aged and elderly people, its asthenia is weakened body resistance, deficiency of the liver and kindey, the kidney failing to nourish the liver, and the excessive rising of liver-YANG that arrives is originally sick for it, or body void just declines, mechanism of qi gasification decline, and the capable Tianjin of unable fortune blood is its root, if it is unsuccessful to meet feelings will, or overstrain too, can make the wind-transformation of rising suddenly and sharply of high partially liver-yang form the acute attack of primary disease, and this i.e. the meaning of " endogenous wind turn ".This sick major lesions position is the brains venation, and with the functional disorder of the many internal organs of multisystem, its asthenia of edge is weakened body resistance, consumes the opinion that impairment of QI blood, fortune blood, Gu Dongyuan are summarized as " healthy energy is from empty " when acute attack again in a large number in addition, the lid deficiency of vital energy can not hemopoietic, fortune blood, can not hemopoietic blood deficiency then; Can not transport blood then blood clotting become the stasis of blood.The deficiency of vital energy is unable to walk Tianjin, Hua Jin also, causes body fluid to stop poly-and to generate expectorant turbid.So expectorant is turbid, blood stasis is by scurrying on the wind within the turn, blocks in deficient brains venation, causes the QI and blood scarcity of warm foster brain network, refreshing the supporting of unit is difficult to keep, the refreshing machine sensible assertive evidence that forms of can not coming in and going out.As seen, in the acute stage and the convalescent period (the especially latter) of primary disease, the deficiency of vital energy, insufficiency of blood, blood stasis, expectorant are turbid, there's no one who doesn't or isn't influence each other between the endogenous wind, and interrelated, becoming vicious cycle is the place, key of the touching refractory of primary disease.Thus, wind-phlegm blood stasis numbness resistance channels and blood stasis due to qi deficiency are the primary disease pathogenesis key of convalescent period.Method of treatment: the convalescent treatment of primary disease should be with giving consideration to both the incidental and fundamental, sets upright with eliminating evil and with being principle.Because the state of an illness drills to stage convalescent period, belong to simulataneous insufficiency and excessive more and lay particular emphasis on weakened body resistance, its void then with the deficiency of vital energy or QI and blood deficiency for seeing more, so answer invigorating primordial QI, yin nourishing blood is with Zhi Qiben.The disease of right hemiplegia, hemianesthesia, stiff tongue and retardation in speech still exists, and this is that the turbid gesture that blocks the brain network of blood stasis, expectorant becomes, still has endogenous wind residual in vivo, so in the void of effecting a permanent cure, it is turbid to reduce phlegm to hold concurrently, and blood stasis dispelling blood, logical brain network pursues residual wind and controls its mark.Follow this treatment thinking, Gu Er drafted benefiting QI and nourishing blood, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation to remove obstruction in the collateral ruling by law it.Observe by big group of case clinical preliminary test, can find apoplexy apoplex involving the channels and collaterals patient with insufficiency of vital energy and blood, the deficiency in origin and excess in superficiality card person of wind-phlegm obstruction of collaterals by blood stasis is in the majority, so the apparatus that meets the tendency aspect treatment has benefiting QI and nourishing blood, expectorant dispels the wind, the prescription of the network function of invigorating blood circulation development new drug preparation so that its blood vessels network road is unobstructed, recovers that QI and blood is warm moistens foster function, and refreshing machine is recovered lost hearing, the limbs bones of the body collectively must be supported, thereby improves patient's quality of life, reduces disability rate.
Be monarch drug with the Radix Astragali in the prescription of the present invention, its sweet in the mouth is warm in nature, mainly goes into the spleen lung, processs with the key medicine that is tonification vigour." book on Chinese herbal medicine meets former " record Radix Astragali " though the property temperature compensation, and can lead to blood circulation regulating, popular meridians do not stagnate can hinder in stopping up yet ".Essentials of Matea Medica proposes again, and the Radix Astragali " is processed and used invigorating middle warmer, beneficial vigour, warm three warmers, strong taste." we reuse Radix Astragali Preparata, make the vigour abundance first, join Radix Angelicae Sinensis with nourshing blood and promoting blood circulation, can control that QI and blood is two loses; Moreover the unable handsome blood of the deficiency of vital energy, fortune blood, so 5 play the double merit of benefiting QI for activating blood circulation mutually with tonifying the blood and stretching the tendon with Caulis Spatholobi; Also have apoplexy convalescent period insufficiency of primordial QI, the blockage of phlegm and blood stasis channels uses Ramulus Cinnamomi and Radix Astragali compatibility, be because the purport of the prescription of the secondary scape Huangqi Guizhi Wuwu Tang that dries in the air, the effect of borrowing Ramulus Cinnamomi to rouse oneself yang-energy can be carried forward the power of Radix Astragali QI invigorating, has the effect of warming the meridian, He Ying, blood stasis dispelling, blood stasis dispelling again.
We are ministerial drug with Radix Angelicae Sinensis, Caulis Spatholobi.The hot little hardship of Radix Angelicae Sinensis sweet in the mouth, warm in nature, go into liver, the heart, spleen three warps.Its sweet suffering can be loose, and it is logical that hardship is let out temperature, among blood-supplementing blood-nourishing, holds concurrently and can invigorate blood circulation, and is particularly suitable to the stasis of blood person that deficient qi and blood is arranged.Caulis Spatholobi is bitter sweet warm in nature, goes into Liver Channel, 5 is " foshousan " mutually with Radix Angelicae Sinensis, can adopt that blood dispels the wind, the merit of promoting blood circulation to restore menstrual flow.
All the other all medicines are adjuvant drug.Pheretima is salty-cold, goes into liver, kidney, lung meridian; The salty bitterness of Hirudo is flat, goes into liver, urinary bladder channel, and two medicines are the good medicine of phlegm reduction of blood circulation promoting, removing blood stasis collateral dredging, apoplexy sees syndrome of blood stasis person, and this is a medicine commonly used.Bombyx Batryticatus acrid in the mouth saltiness is flat, goes into liver, lung meridian, and the expectorant powder junction spasmolytic can relieve dizziness, high fever, infantile convulsions, epilepsy, etc.The Scorpio suffering is put down into Liver Channel, and spasmolytic, activating collaterals to relieve pain can relieve dizziness, high fever, infantile convulsions, epilepsy, etc.The Ramulus Uncariae Cum Uncis sweet in the mouth is slightly cold into liver, pericardium channel, and the suppressing the hyperactive liver to relieve the wind syndrome that we use is main, and idol has surplus heat or for a long time living hot person of the stasis of blood holds concurrently can remove it.The hot temperature of Flos Carthami is gone into the heart, Liver Channel, promoting blood circulation to remove obstruction in the collateral, promoting tissue regeneration by removing blood stasis.Ramulus Cinnamomi is hot sweet warm in nature, goes into the heart, lung, urinary bladder channel, and warming the meridian for promoting the flow of YANG QI reaches battalion thoroughly and defends, and can show in the energy, doublely goes into blood system.The Radix Achyranthis Bidentatae bitter in the mouth is salty flat, mainly goes into liver, kidney, with its temperature compensation Liver and kidney, bone and muscle strengthening with solid its, and can relaxing muscles and tendons to promote blood circulation, and to treat limbs Chinese holly contraction, paralysed its mark of controlling of flaccidity.Rhizoma Chuanxiong, Hirudo, Ramulus Cinnamomi, Flos Carthami, Radix Achyranthis Bidentatae match in the side, strengthen the power of blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.In addition, according to the reason of " control wind and control blood earlier, the blood sector-style is from going out ", nourshing blood and promoting blood circulation all can be treated the disease of puerperal tetanus.Again according to the opinion of " the capable then Tianjin of gas row, the deficiency of vital energy then Tianjin is stopped ", Bombyx Batryticatus, Pheretima and the Radix Astragali coexist under the prerequisite of QI invigorating, and promoting circulation of body fluid is with the expectorant that dispels the wind.With coming from gas, the reason that the symbiosis of the expectorant stasis of blood is relevant organizes the blood stasis dispelling and the two groups of medicines that reduce phlegm altogether in a side by the expectorant stasis of blood, under the monarch drug Radix Astragali of heavy prescription QI invigorating, reducing phlegm then helps blood stasis dispelling with handsome, invigorates blood circulation and helps expectorant, both bring out the best in each other, altogether the effect of the logical brains venation of long memorial.In addition, stroke in convalescent stage is if disease is seen the limbs contracture, and stiff tongue and retardation in speech surely belongs to due to the liver-wind, if meet feelings will, overstrain is all because of swashing mutually, in often can taking place again by " endogenous wind turn ",, search and pick endogenous wind so use Scorpio, Bombyx Batryticatus, Ramulus Uncariae Cum Uncis, Pheretima in the side with the flat liver-yang of diving, the Shujin spasmolytic, the existing multiple health of condition of disease that is beneficial to again can preventing exacerbation after being taken ill, to stop the source in multiple.
Clinical observation and curative effect
One, case is selected
(1) diagnostic criteria (drafting) according to " the clinical research guideline of new Chinese medicine treatment apoplexy " that Ministry of Health of the People's Republic of China formulates.
(2) include the case standard in
(1) meet the apoplexy diagnosis, apoplexy integration 10-24 branch, Chinese medical discrimination is apoplex involving the channels and collaterals syndrome of blood stasis due to qi deficiency patient.
(2) meet cerebral infarction Western medicine diagnose standard.
(3) convalescent period case, 2 thoughtful 6 months inpatients' (comprising hospital bed set up at a patient's home) promptly fall ill.
Two, test method:
(1) EXPERIMENTAL DESIGN: this test is adopted at random, the method for double blinding, parallel control, is multiple center trial.
(2) test routine number
Amount to 200 examples, wherein 100 examples are organized in treatment, matched group 100 examples.
(3) administrated method
4 of each oral the Drug Capsule agent of treatment group, every heavily about 0.4 part, every day 3 times.Around be one course of treatment.
(4) observation index
1, health giving quality observation
(1) patient's mind, language and motor function
(2) nervous system signs
(3) Cranial Computed Tomography
(4) blood examination.
2, safety detects
(1) general health check-up project.
(2) blood, urine, just routine test.
(3) electrocardiogram, liver (part PT), renal function (BUN, Cr) functional check.
Three, curative effect determinate standard (according to new Chinese medicine treatment apoplexy clinical research guideline)
(1) apoplexy efficacy assessment standard
Adopt the nimodipine method: [integration before (integration one treatment back integration before the treatment) ÷ treatment] * 100%, represent with percent.
Be almost recovered: 〉=85%; Produce effects: 〉=50%; Effectively: 〉=20%; Invalid:＜20%.
(2) tcm symptom efficacy assessment standard
Integration before the therapeutic index n=[(treatment-treatment back integration) integration before the ÷ treatment] * 100%.
Be almost recovered: 〉=90; Produce effects: 〉=70%; Effectively: 〉=30%; Invalid:＜20%.
Four, safety evaluatio standard
1 grade: safety, there is not any untoward reaction.
2 grades: compare safety,, need not do any processing and can continue administration if any untoward reaction.
3 grades: safety issue is arranged, and moderate untoward reaction can continue administration after processing.
4 grades: because of test is ended in untoward reaction.
This test, the treatment group is observed 100 examples altogether, wherein produce effects 33 examples, effective 47 examples, invalid 20 examples, total effective rate 80%, viewing duration is not found toxicity, side effect and untoward reaction, and result of the test confirms that this medicine treatment apoplexy blood stasis due to qi deficiency disease is evident in efficacy, is safe and reliable new Chinese medicine.
In addition, need select different adjuvants for use for the preparation of various dosage forms, we have also made experimental selection:
The granule cane sugar powder is selected foundation:
| The investigation project | Adjuvant | ||
| Sucrose | Soluble starch | Dextrin | |
| Mouldability | Very | Very | Very |
| Granule yield (%) | 97 | 95 | 93 |
| Cost (unit/bag) | 2.19 | 3.66 | 5.89 |
Tablet 5% hydroxypropyl cellulose is selected foundation:
| Adjuvant | Granular mass | Tabletting | Disintegration (min) | Sheet heavy (g/ sheet) |
| 5% hydroxypropyl cellulose | Evenly, heavy real | Compressibility is good, rollability is good | 27 | 0.5 |
| 10% gelatin | Evenly, granule is loose | Compressibility is good, rollability is poor | 81 | 0.57 |
| 30% syrup | Inhomogeneous, heavy real | Poor compressibility, rollability are good | 53 | 0.55 |
The specific embodiment:
Embodiments of the invention 1: with Hirudo 75g, Pheretima 75g, Bombyx Batryticatus 25g, Scorpio 17g60 ℃ drying, mix, be ground into fine powder, sieve, mixing, standby; Ramulus Cinnamomi 25g, Rhizoma Chuanxiong 25g, Radix Angelicae Sinensis 50g add 6 times of water gagings, and distillating extracting oil 7 hours filters, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; Medicinal residues add 12 times of water gagings with Radix Astragali 200g, Caulis Spatholobi 100g, Ramulus Uncariae Cum Uncis 25g, Flos Carthami 25g, Radix Achyranthis Bidentatae 25g and decoct three times, soak 40 minutes for the first time, for the second time, each 2 hours for the third time, filter, filtrate and above-mentioned filtrate merge, and being concentrated into relative density is the clear paste of 1.10～1.20 (65 ℃), spray drying adds above-mentioned medical material fine powder and suitable amount of sucrose powder, mixing, spray into volatile oil again, dry granulation sieves, granulate, the bag film-coat, promptly.Swallow, 3 times on the one, one time 1 bag.
Embodiments of the invention 2: with Hirudo 40g, Pheretima 40g, Bombyx Batryticatus 10g, Scorpio 10g60 ℃ drying, mix, be ground into fine powder, sieve, mixing, standby; Ramulus Cinnamomi 10g, Rhizoma Chuanxiong 10g, Radix Angelicae Sinensis 30g add 6 times of water gagings, and distillating extracting oil 7 hours filters, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; Add an amount of beta cyclodextrin and water in the volatile oil, grind, cold drying is ground into fine powder, sieves, and is standby; Radix Astragali 100g, Caulis Spatholobi 50g, Ramulus Uncariae Cum Uncis 10g, Flos Carthami 10g, Radix Achyranthis Bidentatae 10g add 12 times of water gagings and decoct (medicinal residues of carrying behind the oil add) three times when decocting for the second time, soaked 40 minutes for the first time, each 2 hours for the third time for the second time,, decoction liquor and above-mentioned filtrate merge, and filter, and being concentrated into relative density is the clear paste of 1.10～1.20 (65 ℃), spray drying, add above-mentioned medical material fine powder, mixing, alcohol granulation, cross 30 mesh sieves, cold drying, granulate adds an amount of clathrate in the granule, mix homogeneously, sieve, encapsulated, promptly.Oral, 3 times on the one, a 3-4 grain.
Embodiments of the invention 3: with Hirudo 120g, Pheretima 120g, 60 ℃ of dryings of Bombyx Batryticatus 40g, Scorpio 30g, mix, be ground into fine powder, sieve, mixing, standby; Ramulus Cinnamomi 40g, Rhizoma Chuanxiong 40g, Radix Angelicae Sinensis 80g add 6 times of water gagings, and distillating extracting oil 7 hours filters, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; Radix Astragali 300g, Caulis Spatholobi 150g, Ramulus Uncariae Cum Uncis 40g, Flos Carthami 40g, Radix Achyranthis Bidentatae 40g add 12 times of water gagings and decoct (medicinal residues of carrying behind the oil add) three times when decocting for the second time, soaked 40 minutes for the first time, for the second time, each 2 hours for the third time, decoction liquor and above-mentioned filtrate merge, filtration, being concentrated into relative density is the clear paste of 1.10～1.20 (65 ℃), spray drying adds above-mentioned medical material fine powder, mixing, alcohol granulation, cross 30 mesh sieves, cold drying, granulate, add 5% hydroxypropyl cellulose, spray into volatile oil, mixing, tabletting, the bag film-coat, promptly.Oral, 3 times on the one, one time 2.
Other preparation formulation that provides among the present invention prepares if desired, and the applicant found through experiments: can be prepared according to prior art, not need special preparation technology and adjuvant.
Claims (6)
1, a kind of Chinese patent medicine that is used for the treatment of apoplexy, it is characterized in that calculating according to components by weight percent, the raw material of making this Chinese medicine preparation active ingredient is: Radix Astragali 100-300 part, Caulis Spatholobi 50-150 part, Radix Angelicae Sinensis 30-80 part, Rhizoma Chuanxiong 10-40 part, Pheretima 40-120 part, Hirudo 40-120 part, Bombyx Batryticatus 10-40 part, Scorpio 10-30 part, Ramulus Uncariae Cum Uncis 10-40 part, Flos Carthami 10-40 part, Ramulus Cinnamomi 10-40 part, Radix Achyranthis Bidentatae 10-40 part.
2, according to the described Chinese patent medicine that is used for the treatment of apoplexy of claim 1, it is characterized in that calculating according to components by weight percent, the raw material of making this Chinese medicine preparation active ingredient is: 200 parts of the Radixs Astragali, 100 parts of Caulis Spatholobis, 25 parts of Ramulus Cinnamomi, 25 parts of Rhizoma Chuanxiongs, 50 parts of Radix Angelicae Sinensis, 75 parts of Hirudos, 75 parts of Pheretimas, 25 parts of Bombyx Batryticatus, 17 parts of Scorpios, 25 parts of Ramulus Uncariae Cum Uncis, 25 parts on Flos Carthami, 25 parts of Radix Achyranthis Bidentataes.
3, according to claim 1 or the 2 described Chinese patent medicines that are used for the treatment of apoplexy, it is characterized in that: described Chinese patent medicine is granule, hard capsule, soft capsule, tablet, drop pill, oral liquid, injection, slow releasing preparation or controlled release preparation.
4, as any described preparation method that is used for the treatment of the Chinese patent medicine of apoplexy among the claim 1-3, it is characterized in that: Hirudo, Pheretima, Bombyx Batryticatus, Scorpio cold drying, be ground into fine powder, sieve, mixing, standby; Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis add water distillation and extraction volatile oil, filter, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; The same Radix Astragali of medicinal residues, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, Radix Achyranthis Bidentatae decoct with water three times, filter, and filtrate and above-mentioned filtrate merge, be condensed into clear paste, spray drying adds above-mentioned medical material fine powder and suitable amount of sucrose powder, mixing, spray into volatile oil again, dry granulation sieves, granulate, the bag film-coat promptly gets granule.
5, as the described preparation method that is used for the treatment of the Chinese patent medicine of apoplexy of any claim among the claim 1-3, it is characterized in that: Hirudo, Pheretima, Bombyx Batryticatus, Scorpio cold drying, be ground into fine powder, sieve, mixing, standby; Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis add water distillation and extraction volatile oil, filter, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; Add an amount of beta cyclodextrin and water grinding in the volatile oil, cold drying is ground into fine powder, sieves, and is standby; All the other Radixs Astragali, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, Radix Achyranthis Bidentatae decoct with water three times, and the medicinal residues of carrying behind the oil add when decocting for the second time, decoction liquor and the merging of above-mentioned filtrate, filter, be condensed into clear paste, spray drying, add above-mentioned medical material fine powder, mixing is granulated, sieve cold drying, granulate, adding is through the volatile oil of beta cyclodextrin enclose, and mixing sieves, encapsulated, promptly get capsule.
6, as any described preparation method that is used for the treatment of the Chinese patent medicine of apoplexy among the claim 1-3, it is characterized in that: Hirudo, Pheretima, Bombyx Batryticatus, Scorpio cold drying, be ground into fine powder, sieve, mixing, standby; Ramulus Cinnamomi, Rhizoma Chuanxiong, Radix Angelicae Sinensis add water distillation and extraction volatile oil, filter, and divide and get volatile oil, and other collects by device respectively for filtrate and medicinal residues; All the other Radixs Astragali, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Flos Carthami, Radix Achyranthis Bidentatae decoct with water three times, and the medicinal residues of carrying behind the oil add when decocting for the second time, decoction liquor and the merging of above-mentioned filtrate, filter, be condensed into clear paste, spray drying, add above-mentioned medical material fine powder, mixing is granulated, sieve cold drying, granulate, add 5% hydroxypropyl cellulose, spray into volatile oil, mixing, tabletting, the bag film-coat promptly gets tablet.
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| CN101129828B (en) * | 2007-09-12 | 2010-10-13 | 唐晓敏 | Traditional Chinese medicine for treating cataptosis |
| CN101199628B (en) * | 2007-12-18 | 2012-04-18 | 山东步长制药有限公司 | Chinese medicine capsule dose for treating stroke, producing method and quality controlling method thereof |
| CN101411742B (en) * | 2008-11-18 | 2011-08-03 | 山西振东开元制药有限公司 | Capsule for freeing collateral vessels containing astragalus and leech |
| CN103393757B (en) * | 2013-06-26 | 2014-10-29 | 郑奎生 | Traditional Chinese medicine decoction for treating radioactive brain damage |
| CN104435472A (en) * | 2013-09-13 | 2015-03-25 | 孙建民 | Recovery prescription for treating hemiplegia |
| CN105213771A (en) * | 2015-09-30 | 2016-01-06 | 陈玉勇 | A kind of medicine for the treatment of apoplexy and preparation method thereof |
| CN106309952B (en) * | 2016-10-11 | 2019-08-06 | 南阳理工学院 | Oral Chinese herbal medicine for treating cerebral apoplexy and preparation method thereof |
| CN107115428A (en) * | 2017-05-15 | 2017-09-01 | 玉林市中医医院 | It is a kind of to treat Chinese medicine composition of apoplexy and preparation method thereof |
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