CN107115428A - It is a kind of to treat Chinese medicine composition of apoplexy and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of apoplexy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating apoplexy, it is made up of the raw material of following parts by weight：300 600 parts of the Radix Astragali, 180 300 parts of Ligusticum wallichii, 180 300 parts of the red sage root, 90 200 parts of earthworm, 50 150 parts of leech, 90 200 parts of grass-leaved sweetflag, 50 150 parts of polygala, 100 200 parts of the root of kudzu vine.The Chinese medicine composition of the treatment apoplexy is used to be prepared into capsule, tablet, granule, oral liquid.The invention also discloses a kind of preparation method of capsule.Complete square compatibility 5 of the present invention is reasonable, " monarch, minister, help, make " principle is followed, using the Radix Astragali as monarch drug in a prescription, Ligusticum wallichii, the red sage root are ministerial drug, earthworm, leech are adjutant, the monarch and his subjects can be helped, polygala, grass-leaved sweetflag, the root of kudzu vine is make medicine, and this 8 kinds of Chinese medicines, which are shared, has effects that qi and activate blood circulation, disperse blood stasis and dredge collateral, the sharp key of restoring consciouness, and it is steady without invading five ZANG-organs,impairing five ZANG-organs, have no toxic side effect, for stroke in convalescent stage and sequela stage, with definite curative effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of treat Chinese medicine composition of apoplexy and preparation method thereof.
Background technology
Apoplexy also known as " palsy ", " wind " is fast containing the oncoming force, changes the meanings such as many, dizzy servant.This disease is fallen forward with suddenly dusk, does not save people
Thing, or suddenly occur mouth eye fish sticking its mouth out of the water tiltedly, hemiplegia, aphasia is cardinal symptom, and it includes the cerebral hemorrhage of modern medicine, brain blood
Bolt is formed, the disease such as cerebral embolism, facioplegia.
Apoplexy is that cranial vascular disease is one of three dead big reasons of current human diseases, with the development of aging society
Trend, its high incidence, high mortality, high disability rate, seriously jeopardizes human health, jeopardizes the life matter of mid-aged population
Amount.Do not know that how many patient is unable to leave the bed for many years because of hemiplegia at present, or it is handicapped, or unconsciousness, how many
Patient is overwhelmed with sorrow due to can't take care of oneself all the year round.This must make one to feel paralysis due to windstroke to patient, to family, to society
How serious the harm of meeting has, it is impossible to think little of the study on prevention work of " hemiplegia ".
The content of the invention
It is an object of the invention to：For above-mentioned problem, there is provided a kind of Chinese medicine composition for treating apoplexy, this hair
Bright composition compatibility is precise and appropriate, has effects that to receive qi and activate blood circulation, disperse blood stasis and dredge collateral, the sharp key of restoring consciouness.
In order to realize foregoing invention purpose, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
300-600 parts of the Radix Astragali, 180-300 parts of Ligusticum wallichii, 180-300 parts of the red sage root, 90-200 parts of earthworm, 50-150 parts of leech,
90-200 parts of grass-leaved sweetflag, 50-150 parts of polygala, 100-200 parts of the root of kudzu vine.
It is preferred that a kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
400-500 parts of the Radix Astragali, 200-250 parts of Ligusticum wallichii, 200-250 parts of the red sage root, 100-150 parts of earthworm, 80-120 parts of leech,
100-150 parts of grass-leaved sweetflag, 70-110 parts of polygala, 120-180 parts of the root of kudzu vine.
It is preferred that the Chinese medicine composition of the treatment apoplexy is used to be prepared into capsule, tablet, granule, oral liquid.
It is preferred that the preparation method of the capsule is comprised the steps of：
(1) Radix Astragali, Ligusticum wallichii, the red sage root, earthworm, leech, grass-leaved sweetflag, polygala and the root of kudzu vine are weighed in proportion, it is standby after mixing；
(2) 6-10 times of decocting is added to boil 2-3 times above-mentioned mixed medicinal material, each 1-3h, collecting decoction, filtering is obtained
To filtrate；
(3) filtrate is condensed into thick paste, dries, crushes, added starch mixing, load capsule shells, produce the capsule
Agent.
It is preferred that relative density of the thick paste under the conditions of 60-80 DEG C is 1.15-1.25.
It is preferred that the concentration is is concentrated under reduced pressure, described be concentrated under reduced pressure under conditions of 50-70 DEG C is carried out.
In combination of the above thing：
The Radix Astragali, sweet, slightly warm in nature, Return liver, spleen, lung, kidney channel have that invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore are promoted the production of body fluid, Li Shui disappears
Swollen effect.For the key medicine of tonifying Qi, strengthening spleen and tonifying lung, activating qi and collateral coordinates the product of all promoting blood circulations, the work(of its promoting the circulation of qi inrigorating qi and promoting blood circulation is more
Very, thus the monarch drug in a prescription for we of reuse.
Ligusticum wallichii, the red sage root are ministerial drug.Ligusticum wallichii is pungent, warm-natured, Return liver, gallbladder channel, there is blood-activating and qi-promoting, disperse blood stasis and dredge collateral, expelling wind and clearing away cold
The work(of analgesic, is the gas medicine in blood, and its pungent perfume (or spice) of property is walked to alter, can temperature three-way meridian, blood-activating and qi-promoting, wind-expelling pain-stopping walked without keeping, can
The up head, again can thorough fur outside, side reaches four limbs, and can more pass through blood vessels；Red sage root bitter, cold in nature, Thoughts of returning home bag, Liver Channel, with work
Blood menstruation regulating, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, the work(of nourishing blood and tranquilization, have saying for " red sage root work(being like four things simply ", both, which share, mutually benefits
Evident, minister duty is taken charge of in promoting blood circulation, blood-nourishing, promoting circulation of blood altogether.
Earthworm, leech are adjutant.Earthworm is salty-cold, enter liver, lung, bladder warp, has and picks heresy, unimpeded qi and blood, relieving convulsion and spasm into network
Effect.Leech is mild-natured, salty hardship, Return liver, bladder warp, and blood-breaking of invigorating blood circulation, the power broken through is very strong, with earthworm phase 5, can help the monarch and his subjects, increases
Promoting blood circulation, blood-breaking, the effect of removing blood stasis for promoting tissue regeneration.
Polygala, grass-leaved sweetflag, the root of kudzu vine are to make medicine.Polygala is worked hard tepor, and the thoughts of returning home, liver, spleen, lung channel have mental-tranquilization, eliminating the phlegm to open
The work(of key, removing toxicity for detumescence.The arduous temperature of grass-leaved sweetflag, the thoughts of returning home, stomach have functions that helping digestion appetizing, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.Far
Will, grass-leaved sweetflag Papillary, can dissipating phlegm for resuscitation, and can restoring normal coordination between heart and kidney.With cool in nature, the root of kudzu vine with delicate fragrance, the work(of rising Yang, more
Energy consciousness regaining, three medicines share and lead mission.
The compatibility of pharmaceutical composition of the present invention is according to being：Apoplexy is deficiency of vital energy and blood, and marrow secretly consumes, and it is this that internal injury product, which is damaged,
Wind, fire, phlegm, the stasis of blood are caused by this void is developed, to make body imbalance of yin and yang, and qi and blood is inverse disorderly.Qing Dynasty's name doctor's Wang Qingren is thought：Apoplexy belongs to
" qi deficiency to blood stasis, it is indicated that：The gist cured the disease, is to understand qi and blood ".So treatment apoplexy must catch qi and blood, this is basic, is used to
Based on Qi-tonifying drug, it is promoting blood circulation and removing blood stasis supplemented by " activating qi and collateral soup " treat this disease and use till today.Convalescence and sequelae after apoplexy
Phase, healthy tendency day consumption, hemostasis more hinders, qi deficiency to blood stasis as becoming apparent, QI-blood circulation is not smooth, and numbness resistance channels, tendon and vessel is lost to support and caused
The hemiplegia impotence of limbs gives up, hemostasis superinverse, and be jammed brain network blood vessels, and with the passing of time disease prolongs, and deficiency of vital energy essence is lost, and brain becomes homeless foster, and brain network occlusion, brain is lost
Fill, then first god becomes deaf, intelligence decay.As can be seen here, the clear key of qi deficiency to blood stasis, venation block is the sick main pathogenesis, and treatment is worked as
Using qi and activate blood circulation, disperse blood stasis and dredge collateral, the sharp key of restoring consciouness as big method.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
Complete square compatibility 5 of the present invention is reasonable, it then follows " monarch, minister, help, make " principle, using the Radix Astragali as monarch drug in a prescription, is lived with promoting the circulation of qi tonifying Qi
Effect of blood, using Ligusticum wallichii, the red sage root as ministerial drug, department's promoting blood circulation, blood-nourishing, the minister duty of promoting circulation of blood, using earthworm, leech as adjutant, can help monarch altogether
Minister, chemokine blood, blood-breaking, effect of removing blood stasis for promoting tissue regeneration, using polygala, grass-leaved sweetflag, the root of kudzu vine to make medicine, moderate performance, with mental-tranquilization,
Effect of restoring normal coordination between heart and kidney, consciousness regaining, this 8 kinds of Chinese medicines, which are shared, has effects that qi and activate blood circulation, disperse blood stasis and dredge collateral, the sharp key of restoring consciouness, and
Steadily without invading five ZANG-organs,impairing five ZANG-organs, have no toxic side effect.For the qi deficiency to blood stasis of stroke in convalescent stage and sequela stage, train of thought impatency, key closes god
Severe case with unfavourable prognosis, symptoms include hemiplegia, praise powerless, dysphonia, and facial paralysis is touching not to go, very hypophrenia person, with definite
Curative effect.
Embodiment
For the objects, technical solutions and advantages of the present invention are more clearly understood, preferred embodiment is enumerated below, to this hair
It is bright to be further described.However, it is necessary to which many details listed in explanation, specification are used for the purpose of making reader to this
The one or more aspects of invention have a thorough explanation, can also realize the present invention's even without these specific details
These aspects.
Embodiment 1
A kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
Radix Astragali 445g, Ligusticum wallichii 230g, red sage root 234g, earthworm 130g, leech 100g, grass-leaved sweetflag 130g, polygala 100g, the root of kudzu vine
160g。
The invention also discloses a kind of preparation method of capsule, comprise the steps of：
(1) Radix Astragali, Ligusticum wallichii, the red sage root, earthworm, leech, grass-leaved sweetflag, polygala and the root of kudzu vine are weighed in proportion, it is standby after mixing；
(2) decocting that above-mentioned mixed medicinal material is added into 6 times is boiled 2 times, each 1h, collecting decoction, filtering, obtains filtrate；
(3) filtrate is concentrated under reduced pressure under the conditions of 50 DEG C, it is 1.15 (under the conditions of 80 DEG C) to be condensed into relative density
Thick paste, dries, crushes, and adds starch mixing, loads capsule shells, be made 1000, produce the capsule.
Embodiment 2
Other processes of the present embodiment are consistent with embodiment 1, and difference is：
A kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
Radix Astragali 300g, Ligusticum wallichii 180g, red sage root 180g, earthworm 90g, leech 50g, grass-leaved sweetflag 90g, polygala 50g, the root of kudzu vine
100g。
Embodiment 3
Other processes of the present embodiment are consistent with embodiment 1, and difference is：
A kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
Radix Astragali 600g, Ligusticum wallichii 300g, red sage root 300g, earthworm 200g, leech 150g, grass-leaved sweetflag 200g, polygala 150g, the root of kudzu vine
200g。
Embodiment 4
Other processes of the present embodiment are consistent with embodiment 1, and difference is：
A kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
Radix Astragali 400g, Ligusticum wallichii 200g, red sage root 200g, earthworm 100g, leech 80g, grass-leaved sweetflag 100g, polygala 70g, the root of kudzu vine
120g。
Embodiment 5
Other processes of the present embodiment are consistent with embodiment 1, and difference is：
A kind of Chinese medicine composition for treating apoplexy, is made up of the raw material of following parts by weight：
Radix Astragali 500g, Ligusticum wallichii 250g, red sage root 250g, earthworm 150g, leech 120g, grass-leaved sweetflag 150g, polygala 110g, the root of kudzu vine
180g。
Embodiment 6
Other processes of the present embodiment are consistent with embodiment 1, and difference is：
The invention also discloses a kind of preparation method of capsule, comprise the steps of：
(1) Radix Astragali, Ligusticum wallichii, the red sage root, earthworm, leech, grass-leaved sweetflag, polygala and the root of kudzu vine are weighed in proportion, it is standby after mixing；
(2) decocting that above-mentioned mixed medicinal material is added into 10 times is boiled 3 times, each 3h, collecting decoction, filtering, obtains filtrate；
(3) filtrate is concentrated under reduced pressure under the conditions of 70 DEG C, it is 1.25 (under the conditions of 60 DEG C) to be condensed into relative density
Thick paste, dries, crushes, obtain thick paste powder, adds starch mixing, and the weight ratio of starch and the thick paste powder after crushing is
0.2-0.5：1, load capsule shells, be made 1000, produce the capsule.
The Chinese medicine composition of above-mentioned treatment apoplexy can also be routinely preparation process tablet, granule, oral liquid is made.
The application method of Chinese medicine composition of present invention treatment apoplexy is：General capsule is three every time, twice daily；
The each 150mL of oral liquid, twice daily；Tablet, granule are three every time, twice daily.
Clinical observation on the therapeutic effect：
First, general data：Clinical paralytic 46 is chosen, wherein man 23, female 23；31-45 Sui 5,46-60
Year 16, more than 60 years old 25.
2nd, it is grouped
The paralytic that 46 meet inclusive criteria is divided into two groups：Observation group 1 (uses the gained glue of the embodiment of the present invention 1
Wafer), control group (drip-feed medicine group), every group each 23.
3rd, clinical application
(1) observation group 1：The capsule that embodiment 1 is prepared is oral to patient, three every time, twice daily, is within 2 weeks
One course for the treatment of, totally 3 courses for the treatment of, not other medicines intervention.
(2) control group (drip-feed medicine group)：μm/day of snake venom antithrombotic enzyme 0.5, administering mode：Intravenous injection, be within 4 weeks
One course for the treatment of, totally two courses for the treatment of, not other medicines intervention.
4th, evaluation criterion
Be defined according to clinical symptom disappearance, be divided into be almost recovered, it is effective, effective, invalid.
It is almost recovered：Lamprophonia, freedom of movement, life are autonomous, can do labor in general.
It is effective：Language is substantially clear, and action substantially freely, can live on one's own life substantially.
Effectively：Language is substantially clear, but it is slightly inconvenient to take action.
It is invalid：Brain is dizzy to be intended to fall forward, hemianesthesia, hemiplegia, aphasis.
5th, result
It is observation group 1 and control group obvious effective rate comparison sheet referring to table 1.The total effective rate of observation group is better than as seen from Table 1
Control group.
Table 1
Capsule made from 1-6 of the embodiment of the present invention is set to observation group 1-6, wherein observation group 1 is using present invention implementation
The capsule that example 1 is prepared.Clinical effectiveness is relatively shown in Table 2 after each group medication.
Table 2
From table 2 it can be seen that the total effective rate of observation group is better than control group, and use the medicine of observation group 1 and observation group 6
Formula, qi and activate blood circulation, disperse blood stasis and dredge collateral, the sharp key of restoring consciouness effect it is optimal, the number being almost recovered at most, total effective rate also highest.
6th, typical case
Case 1
Chen, man, 60 years old.Suffer stroke more than 3 years, existing symptom has facial paralysis, hemiplegia, inaction on one's sick bed of lying
Inconvenience, is in hospital or treat-and-release, is relieved after still loseing more than 3 years, and the capsule that the embodiment of the present invention 1 is prepared is to trouble
Person is oral, three every time, twice daily, is within 2 weeks a course for the treatment of.After 2 courses for the treatment of, mouth eye recovers normal, can voluntarily be stood up in lying bed,
1 course for the treatment of is taken again, and someone, which helps, slowly to take action, and effect is obvious；It is aided with the consolidation of 3 courses for the treatment of again, it is all after the course for the treatment of terminates
Disease replys as usual, is almost recovered.
Case 2
Liu, man, 55 years old, is worked over nearly 2 months and exaggerates, and prominent sense brain is dizzy to be turned over servants, walking shakiness, right side extremity numbness, moves then
Sweating, lassitude hypodynamia, tongue nature are light, the thin white, small and wiry pulse of tongue.Head CT is reported as：Left side corona radiata cerebral infarction.By present invention implementation
The capsule that example 1 is prepared is oral to patient, three every time, twice daily, and 2 weeks are a course for the treatment of, and totally 3 courses for the treatment of, not other
Pharmaceutical intervention.After the course for the treatment of terminates, all diseases reply as usual, are almost recovered.
Case 3
Beam, female 58 years old, is suffered stroke more than 5 years, extremity numbness, and lower limb are soft and powerless, and walking is walked haltingly, aphasia, tongue
Matter is dull, and tongue is thin white, stringy and slow pulse.The capsule prepared using the embodiment of the present invention 1 is oral, three every time, twice daily,
It is within 2 weeks a course for the treatment of, totally 3 courses for the treatment of, not other medicines intervention.After 2 courses for the treatment of terminate, all diseases are clearly better, and speech is smooth, limb
Body is strong without numbness, after 3 courses for the treatment of terminate, and all diseases reply as usual, then is subject to the consolidation of 2 courses for the treatment of, and patient can live certainly
Reason, smooth running, are almost recovered.
In addition, Chinese medicine composition of the present invention has no toxic side effect, through acute toxicity test and long term toxicity test, press
The dose that clinic allows gives mouse stomach, and mouse activity is normal；The Cmax allowed by clinic is administered to rat, and rat lives
Dynamic and every testing result is without exception.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. a kind of Chinese medicine composition for treating apoplexy, it is characterised in that：It is made up of the raw material of following parts by weight：
300-600 parts of the Radix Astragali, 180-300 parts of Ligusticum wallichii, 180-300 parts of the red sage root, 90-200 parts of earthworm, 50-150 parts of leech, stone Chang
90-200 parts of Pu, 50-150 parts of polygala, 100-200 parts of the root of kudzu vine.
2. a kind of Chinese medicine composition for treating apoplexy according to claim 1, it is characterised in that：By the original of following parts by weight
Material is made：
400-500 parts of the Radix Astragali, 200-250 parts of Ligusticum wallichii, 200-250 parts of the red sage root, 100-150 parts of earthworm, 80-120 parts of leech, stone Chang
100-150 parts of Pu, 70-110 parts of polygala, 120-180 parts of the root of kudzu vine.
3. a kind of application of Chinese medicine composition for treating apoplexy according to claim 1 or 2, it is characterised in that：It is described to control
Treating the Chinese medicine composition of apoplexy is used to be prepared into capsule, tablet, granule, oral liquid.
4. a kind of application of Chinese medicine composition for treating apoplexy according to claim 3, it is characterised in that：The capsule
Preparation method comprise the steps of：
(1) Radix Astragali, Ligusticum wallichii, the red sage root, earthworm, leech, grass-leaved sweetflag, polygala and the root of kudzu vine are weighed in proportion, it is standby after mixing；
(2) 6-10 times of decocting is added to boil 2-3 times above-mentioned mixed medicinal material, each 1-3h, collecting decoction, filtering is filtered
Liquid；
(3) filtrate is condensed into thick paste, dries, crushes, added starch mixing, load capsule shells, produce the capsule.
5. a kind of application of Chinese medicine composition for treating apoplexy according to claim 4, it is characterised in that：The thick paste exists
Relative density under the conditions of 60-80 DEG C is 1.15-1.25.
6. a kind of application of Chinese medicine composition for treating apoplexy according to claim 5, it is characterised in that：The concentration is
It is concentrated under reduced pressure, described be concentrated under reduced pressure under conditions of 50-70 DEG C is carried out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710338940.5A CN107115428A (en) | 2017-05-15 | 2017-05-15 | It is a kind of to treat Chinese medicine composition of apoplexy and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108403983A (en) * | 2018-06-14 | 2018-08-17 | 刘秋艳 | Treat the stagnation resolvation Cyclandelate of cerebral infarction sequela |
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| CN1572314A (en) * | 2003-05-30 | 2005-02-02 | 咸阳步长医药科技发展有限公司 | Chinese patent medicine for treating apoplexy and its preparation method |
| CN101675948A (en) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for treating apoplexy |
| CN102512521A (en) * | 2011-12-16 | 2012-06-27 | 商洛学院 | Traditional Chinese medicine composition for treating apoplexy sequela |
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| CN1572314A (en) * | 2003-05-30 | 2005-02-02 | 咸阳步长医药科技发展有限公司 | Chinese patent medicine for treating apoplexy and its preparation method |
| CN101675948A (en) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for treating apoplexy |
| CN102512521A (en) * | 2011-12-16 | 2012-06-27 | 商洛学院 | Traditional Chinese medicine composition for treating apoplexy sequela |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108403983A (en) * | 2018-06-14 | 2018-08-17 | 刘秋艳 | Treat the stagnation resolvation Cyclandelate of cerebral infarction sequela |
| CN108403983B (en) * | 2018-06-14 | 2021-03-12 | 刘秋艳 | Stasis-removing and thrombus-resisting pill for treating cerebral infarction sequela |
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Application publication date: 20170901 |