CN1245985C - 含有抗坏血酸磷酸酯的组合物 - Google Patents
含有抗坏血酸磷酸酯的组合物 Download PDFInfo
- Publication number
- CN1245985C CN1245985C CNB018132413A CN01813241A CN1245985C CN 1245985 C CN1245985 C CN 1245985C CN B018132413 A CNB018132413 A CN B018132413A CN 01813241 A CN01813241 A CN 01813241A CN 1245985 C CN1245985 C CN 1245985C
- Authority
- CN
- China
- Prior art keywords
- ascorbic acid
- value
- phosphoric acid
- compositions
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- -1 ascorbic acid phosphoric acid esters Chemical class 0.000 title claims abstract description 43
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 37
- 239000011668 ascorbic acid Substances 0.000 title claims abstract description 34
- 235000010323 ascorbic acid Nutrition 0.000 title claims abstract description 34
- 229960005070 ascorbic acid Drugs 0.000 title claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 10
- 239000011575 calcium Substances 0.000 claims abstract description 10
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 10
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 7
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 6
- 239000000551 dentifrice Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 150000002772 monosaccharides Chemical class 0.000 claims description 6
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 claims description 5
- 150000002482 oligosaccharides Chemical class 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 3
- 229940040145 liniment Drugs 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 abstract description 8
- 235000020357 syrup Nutrition 0.000 abstract description 8
- 229920002472 Starch Polymers 0.000 abstract description 7
- 239000008107 starch Substances 0.000 abstract description 7
- 235000019698 starch Nutrition 0.000 abstract description 7
- 229910052782 aluminium Inorganic materials 0.000 abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 34
- 235000002639 sodium chloride Nutrition 0.000 description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 238000002360 preparation method Methods 0.000 description 18
- 239000000377 silicon dioxide Substances 0.000 description 14
- 229960001866 silicon dioxide Drugs 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 11
- 239000000600 sorbitol Substances 0.000 description 11
- 235000010356 sorbitol Nutrition 0.000 description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 9
- 239000004141 Sodium laurylsulphate Substances 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 208000007565 gingivitis Diseases 0.000 description 9
- 239000008213 purified water Substances 0.000 description 9
- 235000012239 silicon dioxide Nutrition 0.000 description 9
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 8
- 229940085605 saccharin sodium Drugs 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 229910052749 magnesium Inorganic materials 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 239000000741 silica gel Substances 0.000 description 6
- 229910002027 silica gel Inorganic materials 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 229960004106 citric acid Drugs 0.000 description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000000811 xylitol Substances 0.000 description 4
- 235000010447 xylitol Nutrition 0.000 description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 3
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 3
- 229960000401 tranexamic acid Drugs 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 description 2
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 229910000323 aluminium silicate Inorganic materials 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229960002303 citric acid monohydrate Drugs 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 239000001685 glycyrrhizic acid Substances 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 159000000003 magnesium salts Chemical class 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 239000000892 thaumatin Substances 0.000 description 2
- 235000010436 thaumatin Nutrition 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 1
- WUOACPNHFRMFPN-VIFPVBQESA-N (R)-(+)-alpha-terpineol Chemical compound CC1=CC[C@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-VIFPVBQESA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 description 1
- 108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 description 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical group OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- XCOJIVIDDFTHGB-UEUZTHOGSA-N Perillartine Chemical compound CC(=C)[C@H]1CCC(\C=N\O)=CC1 XCOJIVIDDFTHGB-UEUZTHOGSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 description 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000001654 beetroot red Substances 0.000 description 1
- 235000012677 beetroot red Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 235000002185 betanin Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- WKZFQFQFYZJKPR-UHFFFAOYSA-N butanedioic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OC(=O)CCC(O)=O WKZFQFQFYZJKPR-UHFFFAOYSA-N 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 238000004939 coking Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- DBTMGCOVALSLOR-AXAHEAMVSA-N galactotriose Natural products OC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](CO)O[C@@H](O[C@H]3[C@@H](O)[C@H](O)O[C@@H](CO)[C@@H]3O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O DBTMGCOVALSLOR-AXAHEAMVSA-N 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N glyceric acid Chemical compound OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- 229940074046 glyceryl laurate Drugs 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 1
- FBJQEBRMDXPWNX-FYHZSNTMSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)C(O)O2)O)O1 FBJQEBRMDXPWNX-FYHZSNTMSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940074371 monofluorophosphate Drugs 0.000 description 1
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- SKDZEPBJPGSFHS-UHFFFAOYSA-N n,n-bis(2-hydroxyethyl)tetradecanamide Chemical compound CCCCCCCCCCCCCC(=O)N(CCO)CCO SKDZEPBJPGSFHS-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 150000003334 secondary amides Chemical class 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229940045845 sodium myristate Drugs 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- JUQGWKYSEXPRGL-UHFFFAOYSA-M sodium;tetradecanoate Chemical compound [Na+].CCCCCCCCCCCCCC([O-])=O JUQGWKYSEXPRGL-UHFFFAOYSA-M 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- PBSRSWFGYPZDAU-FFIPNUABSA-H trimagnesium;[(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2h-furan-4-yl] phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] PBSRSWFGYPZDAU-FFIPNUABSA-H 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种含有抗坏血酸磷酸酯的组合物，其特征在于含有：(A)抗坏血酸磷酸酯或它的盐；(B)一种阴离子表面活性剂；以及(C)或多种选自具有4个或更多个碳原子的单糖醇、寡糖醇和还原淀粉糖浆的糖醇；其中钙和铝离子源的含量小于总组合物的10重量%，并且在25℃下贮存1个月后，该组合物的pH值为8.0或更高。
Description
技术领域
本发明涉及一种含有抗坏血酸磷酸酯的口服和外用组合物。
背景技术
已知抗坏血酸磷酸酯及其盐在开发体内酶活性中具有重要作用，并具有多种生理活性。尤其是，已经承认：它们充当脯氨酰和赖氨酰羟化酶的一种辅酶，并且对于胶原合成是必需的。近年来，一直关注一种抗氧化剂维生素的酯或盐，该维生素可去除体内所产生的过量活性氧，并可防止活组织氧失调。并且，已知这些酯和盐具有多种生理活性。
迄今为止，已经提出大量的含有抗坏血酸磷酸酯及其盐的组合物，包括化妆品(日本专利公开第Sho 62-298508号和日本专利公开第Hei3-63208号)、增白化妆品(日本专利公开第Sho 63-243014和日本专利公开号第Hei 1-305009号和3-133914号)、口腔含化剂(日本专利公开第Sho 62-96408号)、浴剂(日本专利公开第Sho 62-96410号)、口服组合物(日本专利公开第Hei 2-292210、2-292211和4-173727号)、皮肤的外用制剂(日本专利公开第Hei 3-34908、7-206632和8-133951号)等等。
但是，当抗坏血酸磷酸酯或其盐被配制成不同类型的组合物时，由于钙、金属、微生物和pH的影响，它们变得不稳定，伴随出现的问题是它们被转化为抗坏血酸和磷酸。因此，需要保持组合物的稳定。
为了解决这个问题，在配方中加入抗氧化剂或螯合剂。而且，为了将其与水的接触控制到最小程度，已经进行了将此组合物转变为粉末或颗粒的研究(日本专利公开Hei7-252127号)。但是在配制有抗坏血酸磷酸酯及其盐的组合物中，不仅需要使所配制的抗坏血酸磷酸酯稳定，而且还需要使它们在应用中可达到较高的生理活性。
在这个方面，应当选择具有良好应用性的制剂，诸如糊剂、液体或乳膏，以使其保持适当的发泡能力和分散性。同时，在这些制剂中保持抗坏血酸磷酸酯及其盐的结构的同时，应当使这种酯或盐被所应用的活体所吸收。目前需要开发一种技术，其中在这样的含水制剂中，可以稳定地配制一种抗坏血酸磷酸酯或其盐以表现出此效力。
发明的详细说明
本发明的目的是提供一种用处于稳定和活性状态的抗坏血酸磷酸酯及其盐配制的组合物。
为了达到上述目的，本发明人已进行了深入的研究，结果发现，当将一种阴离子表面活性剂，和一种或多种选自含4个或4个以上碳原子的单糖醇、寡糖醇和还原淀粉糖浆的糖醇，配制在含有抗坏血酸磷酸酯或其盐的组合物中时，钙和铝离子源的含量被限制在占此总组合物的10％以下(在此为重量百分比，下同)，并且其起始pH值被调至不低于8.0，优选为8.5至9.5，在将此组合物在25℃下贮存超过一个月以后，含有此抗坏血酸磷酸酯的组合物的稳定性，随时间而提高。另外，长时间贮存以后，可有效地防止这种组合物中抗坏血酸磷酸酯或其盐的残余率下降，以确保其效力的发挥。尽管其起始pH值被调至8.0或以上，特别是8.5至9.5，许多配制了抗坏血酸磷酸酯或其盐的组合物在制备后贮存于室温左右时，其pH值在一个月内将会发生很大的变化，而且在某些情况中，pH值将变得低于8.0。在25℃下贮存一个月后其pH值为8.0或以下时，将不能获得稳定的抗坏血酸磷酸酯及其盐的制剂。因此，我们已经发现在25℃贮存一个月后的组合物的pH值对于抗坏血酸磷酸酯及其盐的制剂的稳定和活性状态是重要的。
附图的简要说明
[附图1]
附图1(A)、1(B)和1(C)分别是显示前牙牙龈状态的示意图，其中附图1(A)显示未患齿龈炎的状态，附图1(B)显示患有轻微程度齿龈炎的状态，附图1(C)显示患有可感知程度齿龈炎的状态。
完成本发明的最佳方式
现在对本发明进行更详细地描述。
本发明组合物的特征是含有(A)抗坏血酸磷酸酯或其盐，(B)阴离子表面活性剂和(C)选自含4个或4个以上碳原子的单糖醇、寡糖醇和还原淀粉糖浆的一种或多种糖醇，其中钙和铝离子源的含量小于总组合物的10％，并且在25℃下贮存一个月后此组合物的pH值为8.0或以上。
抗坏血酸磷酸酯指那些酯，其中抗坏血酸的2、3、5和6位中任意位上的一个或多个羟基被一种化合物例如为磷酸和多磷酸酯化。实例包括抗坏血酸-2-磷酸酯、抗坏血酸-3-磷酸酯、抗坏血酸-6-磷酸酯、抗坏血酸-2-多磷酸酯等等。这些酯的盐包括，例如为碱金属盐和碱土金属盐，诸如钠盐、钾盐、钙盐、镁盐等等。当然，在用于口腔的组合物中，从预防和治疗牙周疾病的角度来看，优选抗坏血酸磷酸酯的镁盐和钠盐。
其量为占总组合物量的0.001至10％，优选0.01至5％。如果量太小，其效力不能满意地表现出来。较大的量可能会降低可用性。
其次，应用阴离子表面活性剂的目的是使此组合物具有适宜程度的发泡能力和分散性。尽管已经承认：加入阴离子表面活性剂将降低抗坏血酸磷酸酯或其盐的稳定性，但是按照本发明，如果配制了阴离子表面活性剂，可以通过将此组合物在25℃贮存一个月后将此组合物的pH值保持在8.0或以上，克服这一点，同时可成功地获得一种稳定的抗坏血酸磷酸酯或其盐的制剂。
在本发明中所用的阴离子表面活性剂是本领域普通技术人员已知常用的那些，包括，例如烷基硫酸盐、聚氧乙烯烷基硫酸盐、α-磺基脂肪酸酯、α-烯属磺酸酯、烷基或羟烷基醚羧酸盐、N-酰化牛磺酸、N-酰化甘氨酸、N-酰化天冬氨酸、N-酰化肌氨酸、N-酰化戊二酸、单烷基磷酸盐、烷基酰胺基醚硫酸盐、烷基(聚)甘油醚硫酸盐、烷基(聚)甘油醚羧酸盐、仲酰胺型N-酰氨基酸盐、酒石酸烷基酰胺、苹果酸烷基酰胺、柠檬酸烷基酰胺、烷基(聚)甘油磺酸盐、单甘油琥珀酸酯等等。其中，优选烷基硫酸盐。
适当地选择一种阴离子表面活性剂的量，通常为占总组合物的0.1至10％，优选为0.5至3％。
本发明的组合物还应当配制有一种或多种选自所含碳原子不小于4个的单糖醇、寡糖醇和还原淀粉糖浆的成分。含4个或4个以上碳原子的单糖醇的实例包括赤藓醇、木糖醇、甘露糖醇、山梨糖醇、半乳糖醇、艾杜糖醇等等。寡糖醇的实例包括麦芽糖醇、乳糖醇、palatinit、麦芽三糖醇(maltotriito1)、异麦芽三糖醇(isomaltotriito1)等等。还原淀粉糖浆包括，例如为一种低糖化的还原淀粉糖浆、一种高糖化的还原淀粉糖浆、一种还原麦芽糖浆等等。这些可单独应用，或者可两种或多种联合应用。
尽管这些糖醇的量可占总组合物的1至80％，优选5至60％，但是这些糖醇以与此组合物中水的量相比0.5或者以上的比例配制，更优选0.5至2.0的比例，最优选0.75至1.5的比例。这样可使抗坏血酸磷酸酯或其盐更有效地发挥其效力。
应当注意的是：甘油是一种具有3个碳原子的单糖醇，它并不具有上述这样一种效力。
在实施本发明中，钙离子源和铝离子源的含量小于总组合物的10％，优选不大于1％，特别优选不大于0.1％，此钙离子源和铝离子源例如一种含钙化合物，例如磷酸氢钙、三代磷酸钙、焦磷酸钙等等，和一种含铝化合物，例如氢氧化铝等等。更特别优选的是，根本不配制这些含钙化合物和含铝化合物。如果，含钙化合物以较大的量存在，抗坏血酸磷酸酯或其盐与钙反应，将形成一种不溶性的钙盐。如果含铝化合物以较大的量存在，由于铝的作用，将促进抗坏血酸磷酸酯或其盐的分解。当含钙化合物和一种含铝化合物的含量被限定在小于总组合物含量的10％的范围内，将会克服上述缺点。
本发明的组合物可用于多种目的，例如口腔和外用目的，并且其制剂可以选择为各种剂型。优选将此组合物制成一种糊剂、液体和霜剂等等。
根据最终的用途和制剂的形式，可用已知的成分和上述的组分一起，进一步配制本发明的组合物。例如，所提供的口腔用组合物可为一种洁牙剂，例如牙膏、液体洁牙剂或其他二一种牙龈按摩用的霜剂；一种表面擦剂或漱口剂。在这种洁牙剂中，可配制常用量的研磨剂、粘合剂、增甜剂、增香剂以及各种类型的有效成分。
优选的研磨剂包括二氧化硅研磨剂，例如硅胶、沉淀二氧化硅、硅铝酸盐、硅锆酸盐(zirconosilicate)(结合钛的二氧化硅)等等。碳酸镁、皂粘土、甲基聚甲基丙烯酸酯等等也可以配制。
可以配制的粘合剂包括一种或多种角叉菜胶；纤维素衍生物，例如羧甲基纤维素钠、甲基纤维素、羟乙基纤维素等等；海藻酸衍生物，例如海藻酸钠、丙二醇藻酸盐等等；树胶例如黄原胶、吉兰糖胶、tranganth胶、卡拉牙胶等等；合成粘合剂，例如聚乙烯醇、聚丙烯酸钠、羧乙烯基聚合物等等；以及无机粘合剂，例如硅胶、蜂胶、laponite等等。
如有必要，除上述糖醇以外，湿润剂还包括甘油、丙二醇、聚乙二醇等等。可以配制的表面活性剂，除前面所述的阴离子表面活性剂以外，还包括非离子表面活性剂，例如癸甘油基月桂酸酯(decaglyceryllaurate)、肉豆蔻酰二乙醇酰胺(myristoyl diethanolamide)等等，以及两性表面活性剂例如甜菜碱。
增香剂包括薄荷醇、茴香脑、香芹酮、丁子香酚、正子癸醇、香茅醇、α-萜品醇、桉树脑、芳樟醇、乙基芳樟醇、香草醛、麝香草酚、薄荷油、留兰香油、冬青油、丁子香油、桉树油等等、它们可以单独配制或两种或多种联合配制。而且，可以配制增甜剂，例如糖精钠、紫苏亭、祝马丁(thaumatin)等等。
在本发明的实施中，还可以配制一种或多种已知的有效成分，包括阳离子杀菌剂，例如氯己定、苄索氯铵、苯扎氯铵、氯化十六烷基吡啶鎓、decalinium chloride等等；酚化合物，例如三氯生、扁柏酚、biozole等等；酶，例如葡聚糖酶、齿斑葡聚糖酶(mutanase)、溶菌酶、淀粉酶、蛋白酶、溶菌素、SOD等等；碱金属一氟磷酸盐例如一氟磷酸钠、一氟磷酸钾等等；氟化物例如氟化钠、氟化亚锡等等；氨甲环酸、ε-氨基己酸、尿囊素、二氢胆甾烷醇、甘草酸、甘草亭酸、甘草磷酸盐、叶绿素、氯化钠、木糖醇、氯化锌、水溶性无机磷酸盐化合物、维生素A、维生素B类、维生素E类及其衍生物。
应当调整本发明组合物的起始pH值，以便在25℃下贮存1个月后，pH为8.0或以上，优选8.0至9.5，特别优选8.5至9.5。规定的pH值不是一个起始值，而是贮存1个月后的pH值的原因是：对于大多数组合物，pH值在邻近室温的情况下，在制备后1个月内发生很大变化，并最终被稳定下来。因此，本发明的发明人注意到：在25℃下贮存1个月后的pH值是重要的。
在这种情况下，pH值的变化根据配制成分的类型而不同。例如，当配制硅胶时，pH值高于25℃下贮存1个月后的pH值，但是当配制沉淀二氧化硅时，情况相反，pH值则下降。因而，为了调节起始pH以便在25℃下贮存1个月后的pH值达到一个预定的pH值，依据组合物的配制，将起始pH值设定在高于或低于预定的贮存1个月后的pH值的水平。如有必要，采用一种技术，其中根据一个预试验可以确定起始pH值和在25℃下贮存1个月后的pH值之间的关系。应当注意的是：通过使用一个常用的pH值调节剂可以调节pH值，为了此目的，通常可应用氢氧化钠或氢氧化钾，并且可以优选使用一种水溶性的柠檬酸盐、磷酸盐、碳酸盐、碳酸氢盐等。
可以用一种处于稳定和活性状态的抗坏血酸磷酸酯或其盐配制本发明的含有抗坏血酸磷酸酯的组合物，它在长时间的贮存后仍显示出具有有效的效力。
实施例
对实验例、实施例和比较实施例进行描述，以特别陈述本发明，但本发明不应当被认为限制在下列的实施例中。
实验例
制备含有下列配方的洁牙剂。使用制备好1至3个月的洁牙剂，并对其进行一周的应用试验，以观察齿龈炎的改善效果。更具体说，10个正常健康的受试者各使用下列每种洁牙剂A和B一周以上，然后停止口腔清洁2天，自我评价齿龈炎状态，并填写一张调查表。应当注意的是：不同洁牙剂的使用间隔是一周或以上。在调查表的结果中，观察前牙上颌和下颌的齿龈，并用下列的方式，以点表示，参考附图1(A)至1(C)。结果显示于表1中。
0：没有齿龈炎(附图1(A))
1：观察到轻度齿龈炎(附图1(B))
2：观察到可以感知程度的齿龈炎(附图1(C))
在附图中，X代表牙齿，Y代表牙龈，而Z代表齿龈炎的位点。
洁牙剂A 洁牙剂B
L-抗坏血酸-2-磷酸酯镁 0.3％ 0.3％
沉淀二氧化硅 15％ 15％
丙二醇 3.5％ 3.5％
羧甲基纤维素 1.5％ 1.5％
对羟基苯甲酸丁酯 0.1％ 0.1％
糖精钠 0.2％ 0.2％
增香剂 1％ 1％
十二烷基硫酸钠 1.5％ 1.5％
二氧化钛 0.5％ 0.5％
柠檬酸 0.1％ 0.1％
70％山梨糖醇溶液 50％ -
85％甘油 - 0％
氢氧化钠 0.3％ 0.35％
纯化水 余量 余量
总计 100.0％ 100.0％
pH值(起始) 8.93 8.96
pH值(在25℃贮存1个月后) 8.58 8.60
与糖醇比的水分含量(重量比) 0.76 0
表1
| 评价点 | 试验开始时 | 洁牙剂试验10天后 | 停止口腔清洁2天后 | |||||||
| 点 | 2 | 1 | 0 | 2 | 1 | 0 | 2 | 1 | 0 | |
| 受试者数量 | 洁牙剂A | 0 | 3 | 7 | 0 | 0 | 10 | 0 | 2 | 8 |
| 洁牙剂B | 0 | 4 | 6 | 0 | 1 | 9 | 0 | 5 | 5 | |
实施例1至5，比较实施例1至4
分别制备具有下列相同配方的洁牙剂，其中按照表2中所示的方式配制表2中所示的组分(二氧化硅、山梨糖醇或甘油)。分别在制备后即刻和在25℃下贮存1个月、6个月和18月后，测定每种所得洁牙剂的pH值。另外，对一种在60℃的恒温室中保存1个月以上的洁牙剂产品、一种在40℃的恒温室中保存6个月以上的洁牙剂产品和一种在25℃的恒温室中保存18个月以上的洁牙剂产品的抗坏血酸磷酸酯镁的残余率进行测定。结果显示于表2中。
相同配方：
L-抗坏血酸-2-磷酸酯镁 0.3％
丙二醇 3.5
羧甲基纤维素 1.5
对羟基苯甲酸丁酯 0.1
糖精钠 0.2
增香剂 1
十二烷基硫酸钠 1.5
二氧化钛 0.5
柠檬酸 0.1
氢氧化钠 适量(大约0.3％)
二氧化硅 表2
山梨糖醇 表2
甘油 表2
纯化水 余量
总计 100.0％
表2
| 项目 | 实施例 | 比较实施例 | |||||||
| 1 | 1 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | |
| 二氧化硅的类型 | A | A | B | B | B | B | A | B | B |
| 二氧化硅量 | 11％ | 11％ | 11％ | 11％ | 11％ | 21％ | 11％ | 16％ | 16％ |
| 山梨糖醇量(70％) | 50％ | 45％ | 50％ | 45％ | 20％ | 40％ | 50％ | - | 30％ |
| 糖醇/水的比例 | 0.78 | 0.65 | 0.78 | 0.65 | 0.29 | 0.67 | 0.78 | 0 | 0.60 |
| 甘油量(85％) | - | - | - | - | 20％ | - | - | 40％ | - |
| 起始pH值 | 7.68 | 8.11 | 8.91 | 8.80 | 8.88 | 8.40 | 7.11 | 8.81 | 7.65 |
| 25℃下贮存1个月后的1H值 | 8.25 | 8.78 | 8.62 | 8.53 | 8.56 | 7.65 | 7.80 | 8.46 | 7.42 |
| 25℃下贮存6个月后的pH值 | 8.36 | 8.86 | 8.62 | 8.51 | 8.52 | 7.62 | 7.87 | 8.42 | 7.41 |
| 25℃下贮存18个月后的pH值 | 8.48 | 8.90 | 8.60 | 8.49 | 8.51 | 7.63 | 7.91 | 8.40 | 7.44 |
| 25℃下贮存18个月后的残余率 | 95.1％ | 96.5％ | 97.0％ | 95.4％ | 92.2％ | 88.2％ | 89.6％ | 77.6％ | 80.6％ |
| 评价 | ○ | ○ | ○ | ○ | △ | × | × | × | × |
二氧化硅类型A：硅胶
二氧化硅类型B：沉淀二氧化硅
实施例6 牙膏
丙二醇 5％
70％山梨糖醇 50
角叉菜胶 1.2
糖精钠 0.2
十二烷基硫酸钠 1.2
对羟基苯甲酸乙酯 0.1
抗坏血酸-2-磷酸酯镁 0.2
柠檬酸一水化物 0.2
硅锆酸盐 18
硅酸酐(Tokuyama公司) 3
增香剂 0.9
氢氧化钠 适量
纯化水 余量
总量 100％
起始pH值 9.28
25℃下贮存1个月后的pH值 8.80
实施例7 牙膏
聚乙二醇400 5％
70％山梨糖醇 40
黄原胶 1.1
木糖醇 10
十二烷基硫酸钠 0.9
肉豆蔻酸二乙醇酰胺 0.9
棕榈酸 0.5
抗坏血酸-2-磷酸酯钠 1
柠檬酸一水化物 0.5
对羟基苯甲酸乙酯 0.1
硅铝酸盐 20
增香剂 1
纯化水 余量
总计 100％
起始pH值 8.71
25℃下贮存1个月后的pH值 8.92
实施例8 牙膏
丙二醇400 4％
山梨糖醇溶液(60％) 40
羧甲基纤维素 2
糖精钠 0.15
十二烷基硫酸钠 1
月桂酰肌氨酸钠 0.2
苯甲酸钠 0.5
氨甲环酸 0.05
抗坏血酸-2-磷酸酯镁 0.05
酒石酸钠 0.02
结合钛的二氧化硅 20
焦化硅石 1
增香剂 1
氢氧化钠 适量
纯化水 余量
总计 100％
起始pH值 9.05
25℃下贮存1个月后的pH值 8.61
实施例9 牙膏
丙二醇 5％
山梨糖醇溶液(60％) 60
藻酸钠 3
糖精钠 0.15
十二烷基硫酸钠 1
对羟基苯甲酸丁酯 0.5
三氯生 0.1
抗坏血酸-2-磷酸酯钠 1
三聚磷酸钠 1
肉豆蔻酸钠 0.2
硅胶 20
增香剂 1
氢氧化钠 适量
纯化水 余量
总计 100％
起始pH值 7.91
25℃下贮存1个月后的pH值 8.58
实施例10牙膏
聚丙烯酸钠 0.5％
黄原胶 0.5
丙二醇 5
70％山梨糖醇溶液 50
糖精钠 0.1
苯甲酸钠 0.3
十二烷基硫酸钠 1.5
氨甲环酸 0.1
抗坏血酸-2-磷酸酯镁 0.5
三乙醇胺 2.5
酒石酸 2
dl-α-生育酚 0.2
软木树树皮提取物 0.05
氟化钠 0.2
硅胶 10
沉淀二氧化硅 10
增香剂 1
碳酸钠 适量
纯化水 余量
总计 100％
起始pH值 8.71
25℃下贮存1个月后的pH值 8.68
实施例11漱口剂
乙醇 10％
甘油 5
山梨糖醇 5
甘露糖醇 3
麦芽糖醇(Maltitol) 3
聚环氧乙烷(60)硬化蓖麻油 1.0
十二烷基硫酸钠 0.1
抗坏血酸-2-磷酸酯镁 0.2
醋酸生育酚 0.05
增香剂 0.3
纯化水 余量
总量 100％
起始pH值 8.44
25℃下贮存1个月后的pH值 8.49
实施例12口腔糊剂
鲸蜡醇 20％
角鲨烷 5
P.O.E.(40)硬化蓖麻油 0.1
木糖醇 8
脱水山梨糖醇一油酸酯 1
十二烷基硫酸钠 0.2
甘草酸 0.1
糖精钠 0.6
抗坏血酸磷酸酯钠 0.3
柠檬酸 0.5
硅酸酐 3
增香剂 0.3
氢氧化钾 适量
纯化水 余量
总量 100％
起始pH值 8.25
25℃下贮存1个月后的pH值 8.38
Claims (3)
1.一种含有抗坏血酸磷酸酯的组合物，其特征在于含有：(A)抗坏血酸磷酸酯或它的盐；(B)阴离子表面活性剂；以及(C)一种或多种选自具有4个或更多个碳原子的单糖醇或寡糖醇的糖醇；和(D)水；其中钙和铝离子源的含量小于总组合物的10重量％，并且在25℃下贮存1个月后，该组合物的pH值为8.0或更高。
2.按照权利要求1的组合物，其中所含的一种或多种糖醇与水的重量比不小于0.5。
3.按照权利要求1或2的组合物，其中所述的组合物呈洁牙剂、牙龈按摩用的霜剂、表面擦剂或漱口剂的形式。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP199213/2000 | 2000-06-30 | ||
| JP2000199213A JP4257479B2 (ja) | 2000-06-30 | 2000-06-30 | アスコルビン酸リン酸エステル又はその塩含有歯磨剤組成物の製造方法 |
| JP199213/00 | 2000-06-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1443072A CN1443072A (zh) | 2003-09-17 |
| CN1245985C true CN1245985C (zh) | 2006-03-22 |
Family
ID=18697266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018132413A Expired - Lifetime CN1245985C (zh) | 2000-06-30 | 2001-03-27 | 含有抗坏血酸磷酸酯的组合物 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4257479B2 (zh) |
| CN (1) | CN1245985C (zh) |
| AU (1) | AU2001242807A1 (zh) |
| WO (1) | WO2002002124A1 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002058662A2 (en) * | 2001-01-24 | 2002-08-01 | Oraceutical Llc | Topical oral care compositions |
| JP2004035416A (ja) * | 2002-06-28 | 2004-02-05 | Sangi Co Ltd | 改良３ｄｓホームケア剤及び虫歯除菌システム |
| CN1909879B (zh) * | 2004-01-20 | 2010-11-24 | 株式会社高丝 | 化妆品 |
| CN101247834B (zh) * | 2005-06-17 | 2013-10-30 | 生命健康科学公司 | 包含一种或多种二-和/或单-（电子转移剂）磷酸酯衍生物或其络合物的载体 |
| CN102802602B (zh) * | 2009-06-08 | 2014-08-06 | 狮王株式会社 | 口腔用组合物 |
| JP5526619B2 (ja) * | 2009-06-25 | 2014-06-18 | ライオン株式会社 | 練歯磨剤組成物 |
| KR20140143136A (ko) * | 2012-03-07 | 2014-12-15 | 라이온 가부시키가이샤 | 구강용 조성물 |
| CN105663015B (zh) * | 2016-03-24 | 2018-06-29 | 广州健朗医用科技有限公司 | 一种孕产妇专用蜂胶牙膏及其制备方法 |
| CN111759788A (zh) * | 2020-07-27 | 2020-10-13 | 浙江爱尚日用品有限公司 | 一种防治口腔溃疡型牙膏 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2973511B2 (ja) * | 1990-11-06 | 1999-11-08 | ライオン株式会社 | 口腔用組成物 |
| JP2000351905A (ja) * | 1999-04-05 | 2000-12-19 | Showa Denko Kk | アスコルビン酸誘導体含有組成物 |
-
2000
- 2000-06-30 JP JP2000199213A patent/JP4257479B2/ja not_active Expired - Fee Related
-
2001
- 2001-03-27 WO PCT/JP2001/002466 patent/WO2002002124A1/ja active Application Filing
- 2001-03-27 CN CNB018132413A patent/CN1245985C/zh not_active Expired - Lifetime
- 2001-03-27 AU AU2001242807A patent/AU2001242807A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1443072A (zh) | 2003-09-17 |
| AU2001242807A1 (en) | 2002-01-14 |
| JP2002020292A (ja) | 2002-01-23 |
| JP4257479B2 (ja) | 2009-04-22 |
| WO2002002124A1 (fr) | 2002-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1222270C (zh) | 口腔组合物 | |
| CN1575158A (zh) | 牙齿增白方法、牙齿增白组合物和牙齿增白装置 | |
| CN1154469C (zh) | 抗牙齿菌斑的口腔牙齿洁治剂组合物 | |
| CN1243537C (zh) | 含有通过至少一种马来酸酐共聚物稳定化的至少一种氧化敏感性亲水性活性成分的组合物的化妆上和 /或皮肤上的用途 | |
| CN1232241C (zh) | 牙齿增白贴片 | |
| CN1221238C (zh) | 肟基－和羟氨基－前列腺素的用途 | |
| CN1165287C (zh) | 含有杀真菌剂和阳离子成分的组合物 | |
| CN1882353A (zh) | 催涎剂和混合该催涎剂的口腔用组合物以及食品组合物 | |
| CN100335081C (zh) | 含有牡丹根皮提取物作为活性成分的组合物 | |
| CN1136832C (zh) | 皱纹改善剂 | |
| CN1095586A (zh) | 口用组合物 | |
| CN1105235A (zh) | 防治齿斑和龈炎的口用组合物 | |
| CN1652744A (zh) | 包含二羧基官能化聚有机硅氧烷的口腔护理组合物 | |
| CN1101254A (zh) | 口用卫生组合物 | |
| CN1304074C (zh) | 口腔用组合物 | |
| CN1419438A (zh) | 用2－脱羧基－2－磷酸亚基衍生物治疗脱发的组合物和方法 | |
| CN1245985C (zh) | 含有抗坏血酸磷酸酯的组合物 | |
| CN1220596A (zh) | 含有十六烷基氯化吡啶鎓和一种两性表面活性剂的漱口药组合物 | |
| CN1674921A (zh) | 多羟基烷烃的脂肪酸酯和吡啶羧基衍生物的新型复合物 | |
| CN1200264A (zh) | 水性化妆品组合物以及使尿酸稳定溶于其中的方法 | |
| CN1735398A (zh) | 口腔用组合物用基质及口腔用组合物 | |
| CN1160064C (zh) | 选择性抗菌组合物 | |
| CN1610533A (zh) | 包含酪蛋白磷酸肽复合物和氟化物的稳定的口腔用组合物 | |
| CN1859906A (zh) | 含有多价金属无机盐包覆的视黄酸纳米颗粒的组合物 | |
| CN1144475A (zh) | 阿尔发羟基酸、阿尔发酮酸和相关化合物的多氨盐 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20060322 |
|
| CX01 | Expiry of patent term |