CN1216630C - External use medicine for treating vaginitis - Google Patents
External use medicine for treating vaginitis Download PDFInfo
- Publication number
- CN1216630C CN1216630C CN 03111408 CN03111408A CN1216630C CN 1216630 C CN1216630 C CN 1216630C CN 03111408 CN03111408 CN 03111408 CN 03111408 A CN03111408 A CN 03111408A CN 1216630 C CN1216630 C CN 1216630C
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- CN
- China
- Prior art keywords
- externally
- medicine
- external use
- medicaments
- vaginitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 35
- 201000008100 Vaginitis Diseases 0.000 title abstract description 8
- 206010046914 Vaginal infection Diseases 0.000 title abstract description 7
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960000282 metronidazole Drugs 0.000 claims abstract description 7
- 229960000988 nystatin Drugs 0.000 claims abstract description 7
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract 3
- 229940079593 drug Drugs 0.000 claims description 9
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 3
- 201000004624 Dermatitis Diseases 0.000 abstract description 7
- 208000010668 atopic eczema Diseases 0.000 abstract description 7
- 208000003251 Pruritus Diseases 0.000 abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 4
- 244000045947 parasite Species 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 210000001215 vagina Anatomy 0.000 abstract description 4
- 208000025865 Ulcer Diseases 0.000 abstract description 3
- 230000007803 itching Effects 0.000 abstract description 3
- 231100000397 ulcer Toxicity 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 241000132012 Atractylodes Species 0.000 abstract 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 abstract 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 abstract 1
- 241000212948 Cnidium Species 0.000 abstract 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 abstract 1
- 241000229179 Ledebouriella Species 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 206010039509 Scab Diseases 0.000 abstract 1
- 241000245665 Taraxacum Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 241001502500 Trichomonadida Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 229940097275 indigo Drugs 0.000 abstract 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 abstract 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 210000003756 cervix mucus Anatomy 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 201000005630 leukorrhea Diseases 0.000 description 2
- 230000002969 morbid Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 208000005687 scabies Diseases 0.000 description 2
- 206010046901 vaginal discharge Diseases 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 208000032159 Vaginal inflammation Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses an externally-used medicament for treating vaginitis, which is jointly prepared from traditional Chinese medicaments and western medicaments. The traditional Chinese medicaments mainly comprise the raw medicinal materials containing ledebouriella root, kuhseng, phellodendron bark, common cnidium fruit, atractylodes rhizome, natural indigo and dandelion. The western medicaments mainly comprise the raw medicinal materials containing nystatin and metronidazole. The externally-used medicament can be made into any one common externally-used dosage. The externally-used medicament has the functions of clearing away heat, relieving inflammation, eliminating dampness, destroying parasites, relieving itching and eliminating swelling, eczema, damp sore, scab and lichen, etc., has the good therapeutic effects on treating various types of nonspecific and senile vaginitis and vagina ulcer caused by trichomonad, mildew and diabetes, and has the advantages of short treatment course and high curative ratio.
Description
Technical field
The present invention relates to the colpitic medicine for external use of a kind of treatment, belong to medical technical field.
Background technology
The gynaecologic vaginal inflammation is women's commonly encountered diseases and a frequently-occurring disease.Generally be divided into infusorian property, mycotic, non-specific, senile and diabetic vaginitis.Ulcer of vagina, viral skin ulcer rash also are common gynecological diseases.At present, both at home and abroad estrogen and Chinese and Western these gynaecopathia of antibacterials combined treatment of adopting more, all there be toxic and side effects and Drug resistance in various degree in long-term prescription, and therapeutic effect is not very good yet.
Summary of the invention
The object of the present invention is to provide the colpitic medicine for external use of a kind of treatment, this medicine all has better curative effect to infusorian, mycete, various vaginitiss and ulcer of vagina non-specific, senile and that diabetes cause, and short treating period, and the cure rate height can thoroughly effect a radical cure.
Medicine for external use of the present invention is formed by Chinese medicine and Western medicine formulated in combination, and the raw material of Chinese medicine medicine is made up of Radix Saposhnikoviae, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, Rhizoma Atractylodis, Indigo Naturalis, Herba Taraxaci, and the Western medicine crude drug is made up of nystatin and metronidazole.
Radix Saposhnikoviae: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic; Radix Sophorae Flavescentis: heat clearing and damp drying wind dispelling insecticide, morbid leukorrhea; Antipruritic disease such as grade.Cortex Phellodendri: heat clearing and damp drying, sore swollen toxin, sensible heat etc. is removed in the eczema pathogenic fire purging.Fructus Cnidii: cold expelling dispels the wind, dampness removing to stop itchin parasite killing, pudendum pruritus due to damp pathogen, eczema, eczema scabies etc.Indigo Naturalis: heat-clearing and toxic substances removing, removing heat from blood looses swollen, Rhizoma Atractylodis: dampness wind-damp dispelling.Herba Taraxaci: antiinflammatory heat clearing away.Nystatin and metronidazole have parasite killing, antiinflammatory, itching relieving effect.
The weight proportion of crude drug of the present invention is: Radix Saposhnikoviae 6～10%, Radix Sophorae Flavescentis 15～20%, Cortex Phellodendri 6～10%, Fructus Cnidii 15～20%, Rhizoma Atractylodis 6～10%, Indigo Naturalis 4～8%, Herba Taraxaci 15～20%, nystatin 6～10%, metronidazole 10～15%.
Be preferably: the weight proportion of crude drug of the present invention is: Radix Saposhnikoviae 8%, Radix Sophorae Flavescentis 16%, Cortex Phellodendri 8%, Fructus Cnidii 16%, Rhizoma Atractylodis 8%, Indigo Naturalis 6%, Herba Taraxaci 16%, nystatin 8%, metronidazole 14%.
Medicine for external use of the present invention can be ground into powder and incapsulate use.Also can adopt the conventional method of Chinese medicine preparation to be mixed with any conventional external preparation, as powder, spray, suppository.
The present invention adopts Chinese medicine to combine with Western medicine, has effects such as heat clearing and inflammation relieving, dampness, killing parasites for relieving itching, detumescence, eczema, scabies.Can effectively treat rotten to the corn white pustule of exanthema vesiculosum, eczema shape or lamellar eczema that infusorian, mycete cause, herpes simplex virus, diabetic vaginitis.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by clinical observation on the therapeutic effect test.
1, physical data
Accept female patient totally 500 examples for medical treatment, the age is between 18～60 years old.
2, diagnostic criteria
Profuse leukorrhea, yellow or smelly, pollute underwear, pudendal pruritus, the vaginal secretions smear for microscopic examination is found infusorian or mycete, can be diagnosed as vaginitis.And the vaginal secretions amount is few, Se Bai or faint yellow, and no pudendum pruritus is not generally thought morbid state.
3, Therapeutic Method
External every day once, each 1.5 grams, 7 days is a course of treatment, medicine is sent into vagina after will vaginadouche before the medication clean.
4, efficacy assessment standard
Cure: above transference cure, mucosa change over to normally, and laboratory examination is negative.Take a turn for the better: transference cure, chemical examination has 1-2 infusorian or mycete.
5, therapeutic outcome
Cure patient's 480 examples, 20 examples take a turn for the better.Cure rate is 96%, and total effective rate is 100%.Medicine for external use of the present invention uses and can take effect for 1 time.The lighter, vaginitiss such as simple property infusorian or mycete can be cured in 7 days, and heavier person, cured in 7-10 days by two kinds or merge other bacterial infection person.
Claims (3)
1, the colpitic medicine for external use of a kind of treatment is characterized in that: be made up of following materials of weight proportions medicine: Radix Saposhnikoviae 6～10%, Radix Sophorae Flavescentis 15～20%, Cortex Phellodendri 6～10%, Fructus Cnidii 15～20%, Rhizoma Atractylodis 6～10%, Indigo Naturalis 4～8%, Herba Taraxaci 15～20%, nystatin 6～10%, metronidazole 10～15%.
2, the colpitic medicine for external use of a kind of treatment according to claim 1, it is characterized in that: wherein the consumption of each crude drug is: Radix Saposhnikoviae 8%, Radix Sophorae Flavescentis 16%, Cortex Phellodendri 8%, Fructus Cnidii 16%, Rhizoma Atractylodis 8%, Indigo Naturalis 6%, Herba Taraxaci 16%, nystatin 8%, metronidazole 14%.
3, the preparation method of claim 1 or 2 described medicine for external use is characterized in that: the crude drug pulverize is incapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03111408 CN1216630C (en) | 2003-04-07 | 2003-04-07 | External use medicine for treating vaginitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03111408 CN1216630C (en) | 2003-04-07 | 2003-04-07 | External use medicine for treating vaginitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1442176A CN1442176A (en) | 2003-09-17 |
| CN1216630C true CN1216630C (en) | 2005-08-31 |
Family
ID=27796880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03111408 Expired - Fee Related CN1216630C (en) | 2003-04-07 | 2003-04-07 | External use medicine for treating vaginitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1216630C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101690785B (en) * | 2009-10-15 | 2011-12-21 | 贵州百灵企业集团制药股份有限公司 | Bacteriostatic lotion and preparation method thereof |
-
2003
- 2003-04-07 CN CN 03111408 patent/CN1216630C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1442176A (en) | 2003-09-17 |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |