CN119679867A - A veterinary Chinese medicine granule preparation and preparation method thereof - Google Patents
A veterinary Chinese medicine granule preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a veterinary traditional Chinese medicine granule preparation and a preparation method thereof, wherein the traditional Chinese medicine granule preparation comprises, by weight, 10-15 parts of sweet wormwood herb, 10-20 parts of mung bean extract, 10-15 parts of honeysuckle, 15-20 parts of cordate houttuynia, 15-20 parts of red paeony root, 15-20 parts of madder extract and the balance of auxiliary materials according to 100 parts. The formula of the invention complements each other, has the characteristics of synergistic effect, good antipyretic effect, less side effect, obvious function, safety, no toxicity, good stability, high bioavailability and the like, and is used for treating and relieving the fever symptoms of animal organisms. Has definite curative effect and small side effect in treating animal hyperthermia and summer heat relieving.
Description
Technical Field
The invention relates to a veterinary traditional Chinese medicine granule preparation and a preparation method thereof, belonging to the technical field of pharmaceutical preparations.
Background
While the poultry industry develops towards the intensive and large-scale directions, various infectious diseases are often popular, wherein viral infectious diseases are diseases which develop rapidly and are difficult to cure, accounting for 1/4 of the poultry diseases, and causing huge economic losses each year. At present, the phenomenon of adding chemicals or antibiotics into livestock and poultry raising feeds is very common, and the livestock and poultry raising risks are increased increasingly due to the abuse of drugs, unreasonable compatibility and the like, so that immunosuppression, propagation disorder and low survival rate are caused. Meanwhile, due to long-term use and continuously increased use dosage, viruses even cause mutation infection to human beings, serious harm exists to the life of the human beings, western medicines have very limited effects, and medicine residues are caused.
Sweet wormwood is bitter and pungent in flavor and cold in nature, and Shen nong Ben Cao Jing (Shen nong's herbal), it is recorded that sweet wormwood has the actions of removing deficiency heat, cooling blood, relieving summer-heat and treating malaria, and also has the actions of resisting virus, resisting plasmodium, promoting bile flow, relieving fever, easing pain, resisting inflammation, resisting tumor, reducing blood pressure and resisting arrhythmia, but is contraindicated for people with weakness of spleen and stomach and diarrhea.
Radix Rubiae, herba Saururi qian, herba Chenopodii, lignum sappan, plumbum Preparatium, saviae Miltiorrhizae radix, and Red Sage. Radix Rubiae is one of the red dyes used by human beings at the earliest time, and is described in ancient literature, and perennial climbing herbs are grown on hillside roads, edges, bushes and forests, and are dug in spring and autumn. Has effects of cooling blood, stopping bleeding, promoting blood circulation, and removing blood stasis. Is used for treating hemoptysis due to blood heat, puerperal abdominal pain due to blood stasis, traumatic injury, rheumatalgia, etc. The medical works of Ben Cao Hui Yan (Fu Jian drug Zhi) and the like record that madder root has the effects of cooling blood, removing blood stasis, stopping bleeding and dredging channels, and is mainly used for treating bleeding symptoms caused by blood heat recklessly flowing, blood stasis amenorrhea, traumatic injury, rheumatalgia and the like.
Mung beans are seeds of mung beans which are leguminous plants, are called green beans, planted beans and the like, and have a cultivation history of more than two thousand years in China. Mung beans have pharmacological effects of reducing blood lipid, reducing cholesterol, resisting allergy, resisting bacteria and tumors, stimulating appetite, protecting liver and kidney. Mung beans contain globulin and polysaccharide, and can promote the decomposition of cholesterol in animals into cholic acid in the liver, accelerate the secretion of bile salts in bile and reduce the absorption of cholesterol by small intestine. The effective components of semen Phaseoli Radiati have antiallergic effect, and can be used for the adjuvant treatment of anaphylaxis such as urticaria. Mung beans have an inhibitory effect on staphylococci. The proteins and phospholipids contained in mung beans have the functions of exciting nerves and stimulating appetite. Mung beans contain rich trypsin inhibitors, can protect the liver, reduce protein decomposition and reduce azotemia, thereby protecting the kidney.
At present, chemical medicines are used for treating animal fever symptoms clinically, but long-term use of the chemical medicines is easy to cause drug resistance of animals, accumulation of the chemical medicines in animal bodies is easy to occur if the dosage of the chemical medicines is increased continuously, so that human health is threatened, the traditional Chinese medicine preparation does not have adverse effects, the application of the traditional Chinese medicine is accepted by veterinary clinics, and the application of the traditional Chinese medicine preparation to prevention and treatment of animal diseases becomes a trend of livestock raising industry.
Patent CN104474007A discloses a veterinary antipyretic sweet wormwood licorice granule and soluble powder preparation and a preparation method thereof, and the prepared sweet wormwood licorice preparation is used for treating summer heat fever, yin deficiency fever, night fever and early cooling, bone steaming and fatigue fever, malaria cold and heat, damp-heat jaundice caused by eperythrozoon of livestock and aquatic breeding animals. Has the characteristics of obvious function, safety, no toxicity, good stability, high bioavailability and the like.
The present invention has been made in view of the above problems.
Disclosure of Invention
Aiming at the defects of the prior art, the first aim of the invention is to provide a veterinary traditional Chinese medicine granule preparation.
A second object of the present invention is to provide a process for the preparation comprising the above formulation.
In order to achieve the first purpose, the invention is realized by the following technical scheme that the veterinary traditional Chinese medicine granule preparation comprises, by weight, 10-15 parts of sweet wormwood herb, 10-20 parts of mung bean extract, 10-15 parts of honeysuckle, 15-20 parts of cordate houttuynia, 15-20 parts of red paeony root, 15-20 parts of madder extract and the balance of auxiliary materials according to 100 parts.
By adopting the technical scheme, the formula components complement each other, and the traditional Chinese medicine composition has the characteristics of synergistic effect, good antipyretic effect, less side effect, obvious function, safety, no toxicity, good stability, high bioavailability and the like, and is used for treating and relieving fever symptoms of animal organisms. Has definite curative effect and small side effect in treating animal hyperthermia and summer heat relieving.
Preferably, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose.
Preferably, the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 2-3:3-5:4-6:1.
Preferably, the method for extracting the madder extract comprises the following steps:
s1, crushing radix rubiae, adjusting the water content, and placing the crushed radix rubiae into a screw extruder for extrusion spraying treatment to obtain extruded radix rubiae;
S2, placing the extruded madder into distilled water, steaming for 1-5 hours, filtering and collecting filtrate A, adding distilled water into filter residues, continuously steaming for 1-5 hours, and filtering and collecting filtrate B;
S3, combining the filtrate A and the filtrate B, steaming until the filtrate is 20-50ml, and drying to obtain the madder extract.
Preferably, in the step S1, the particle size of the madder is 50-100 meshes, the water content of the madder is regulated to 10-30%, the extrusion spraying condition is that the extrusion temperature is 150-180 ℃, and the extrusion rotating speed is 150-200r/min.
Preferably, in step S2, the pH is adjusted to 5.0-5.5 with citric acid before each cook.
Preferably, the extraction method of the mung bean extract comprises the following steps of crushing mung beans to 100-150 meshes, adding 10-15 times of distilled water according to weight, boiling at a low temperature of 40-50 ℃ for 2-5 hours, filtering, washing filter residues, merging filtrate, concentrating under reduced pressure to 20-50ml, adding 4-6 times of ethanol solution, standing overnight, filtering, taking filtrate, concentrating, and drying to obtain the mung bean extract.
In order to achieve the second purpose, the invention is realized by the following technical scheme that the preparation method of the veterinary traditional Chinese medicine granule preparation comprises the following steps:
Respectively weighing sweet wormwood, honeysuckle, cordate houttuynia and red paeony root, crushing, placing in an extraction tank, placing in 10-15 times of distilled water, extracting for 2-5 hours at low temperature in vacuum, filtering, taking filtrate, and continuously concentrating until the volume of the filtrate is half to obtain thick paste;
and step two, adding auxiliary materials into the thick paste, stirring for 0.5-1h, mixing and granulating by using a boiling drying granulator, and drying.
Preferably, the relative density of the thick paste is 1.25-1.30.
Preferably, the particle size after granulation is 30-50 mesh.
The invention has the beneficial effects that:
The formula of the application complements each other, has the characteristics of synergistic effect, good antipyretic effect, less side effect, obvious function, safety, no toxicity, good stability, high bioavailability and the like, and is used for treating and relieving the fever symptoms of animal organisms. Has definite curative effect and small side effect in treating animal hyperthermia and summer heat relieving.
Detailed Description
The invention is further described in connection with the following detailed description, in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
Example 1
A veterinary Chinese medicinal granule comprises herba Artemisiae Annuae 10kg, semen Phaseoli Radiati extract 10kg, flos Lonicerae 15kg, herba Houttuyniae 20kg, radix Paeoniae Rubra 20kg, radix Rubiae extract 15kg and adjuvants 10kg.
In the embodiment, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 2:3:6:1.
In this embodiment, the method for extracting the madder extract includes the following steps:
S1, crushing radix rubiae to 50 meshes, adjusting the water content to 15%, and placing the crushed radix rubiae into a screw extruder for extrusion spraying treatment, wherein the extrusion spraying condition is that the extrusion temperature is 150 ℃, and the extrusion rotating speed is 200r/min to obtain the extruded radix rubiae;
s2, placing the extruded madder into distilled water, adjusting the pH to 5.0 by using citric acid, steaming and boiling for 2 hours, filtering and collecting filtrate A, adding distilled water into filter residues, adjusting the pH to 5.0 by using citric acid, continuously steaming and boiling for 5 hours, and filtering and collecting filtrate B;
And S3, combining the filtrate A and the filtrate B, steaming until the filtrate is 20ml, and drying to obtain the madder extract.
In this embodiment, the method for extracting mung bean extract comprises pulverizing mung bean to 150 mesh, adding 10 times of distilled water by weight, boiling at 50deg.C for 5 hr, filtering, washing the residue, mixing filtrates, concentrating under reduced pressure to 20ml, adding 6 times of ethanol solution, standing overnight, filtering, collecting filtrate, concentrating, and drying to obtain mung bean extract.
A preparation method of a veterinary traditional Chinese medicine granule preparation comprises the following steps:
Respectively weighing sweet wormwood, honeysuckle, cordate houttuynia and red paeony root, crushing to 50 meshes, placing in an extraction tank, placing 10 times of distilled water, extracting for 5 hours at low temperature in vacuum, filtering, taking filtrate, and continuously concentrating until the volume of the filtrate is half to obtain thick paste, wherein the relative density of the thick paste is 1.25;
and step two, adding auxiliary materials into the thick paste, stirring for 1h, mixing and granulating by using a boiling drying granulator, and drying the mixture with the particle size of 30 meshes.
Example 2
A veterinary Chinese medicinal granule comprises herba Artemisiae Annuae 15kg, semen Phaseoli Radiati extract 15kg, flos Lonicerae 10kg, herba Houttuyniae 16kg, radix Paeoniae Rubra 15kg, radix Rubiae extract 20kg and adjuvants 9kg.
In the embodiment, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 3:3:5:1.
In this embodiment, the method for extracting the madder extract includes the following steps:
S1, crushing radix rubiae to 100 meshes, adjusting the water content to 25%, and placing the crushed radix rubiae into a screw extruder for extrusion spraying treatment, wherein the extrusion spraying condition is that the extrusion temperature is 150 ℃, and the extrusion rotating speed is 150r/min to obtain the extruded radix rubiae;
s2, placing the extruded madder into distilled water, adjusting the pH to 5.5 by using citric acid, steaming for 1h, filtering and collecting filtrate A, adding distilled water into filter residues, adjusting the pH to 5.0 by using citric acid, continuously steaming for 1h, and filtering and collecting filtrate B;
and S3, combining the filtrate A and the filtrate B, steaming until the filtrate is 30ml, and drying to obtain the madder extract.
In this example, the method for extracting mung bean extract comprises pulverizing mung bean to 100 mesh, adding 15 times of distilled water, decocting at 40deg.C for 3 hr, filtering, washing the residue, mixing filtrates, concentrating under reduced pressure to 30ml, adding 4 times of ethanol solution, standing overnight, filtering, collecting filtrate, concentrating, and drying to obtain mung bean extract.
A preparation method of a veterinary traditional Chinese medicine granule preparation comprises the following steps:
Respectively weighing sweet wormwood, honeysuckle, cordate houttuynia and red paeony root, crushing to 100 meshes, placing in an extraction tank, placing 10 times of distilled water, extracting for 3 hours at low temperature in vacuum, filtering, taking filtrate, and continuously concentrating until the volume of the filtrate is half to obtain thick paste, wherein the relative density of the thick paste is 1.30;
And step two, adding auxiliary materials into the thick paste, stirring for 0.5h, mixing and granulating by using a boiling drying granulator, and drying the mixture with the particle size of 40 meshes.
Example 3
A veterinary Chinese medicinal granule comprises herba Artemisiae Annuae 12kg, semen Phaseoli Radiati extract 15kg, flos Lonicerae 12kg, herba Houttuyniae 20kg, radix Paeoniae Rubra 16kg, radix Rubiae extract 20kg and adjuvants 5kg.
In the embodiment, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 3:5:4:1.
In this example, the extraction method of the madder extract is the same as in example 1.
In this example, the method for extracting mung bean extract comprises pulverizing mung bean to 100 mesh, adding 15 times of distilled water, decocting at 40deg.C for 2 hr, filtering, washing the residue, mixing filtrates, concentrating under reduced pressure to 50ml, adding 4 times of ethanol solution, standing overnight, filtering, collecting filtrate, concentrating, and drying to obtain mung bean extract.
A preparation method of a veterinary traditional Chinese medicine granule preparation comprises the following steps:
respectively weighing sweet wormwood, honeysuckle, cordate houttuynia and red paeony root, crushing to 100 meshes, placing in an extraction tank, placing 10 times of distilled water, extracting for 2 hours at low temperature in vacuum, filtering, taking filtrate, and continuously concentrating until the volume of the filtrate is half to obtain thick paste, wherein the relative density of the thick paste is 1.30;
and step two, adding auxiliary materials into the thick paste, stirring for 1h, mixing and granulating by using a boiling drying granulator, and drying the mixture with the particle size of 50 meshes.
Example 4
A veterinary Chinese medicinal granule comprises herba Artemisiae Annuae 13kg, semen Phaseoli Radiati extract 20kg, flos Lonicerae 15kg, herba Houttuyniae 15kg, radix Paeoniae Rubra 18kg, radix Rubiae extract 16kg and adjuvants 3kg.
In the embodiment, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 2:3:4:1.
In this example, the extraction method of the madder extract is the same as in example 1.
In this example, the extraction method of mung bean extract was the same as in example 1.
A preparation method of a veterinary Chinese medicinal granule preparation is the same as in example 1.
Example 5
A veterinary Chinese medicinal granule comprises herba Artemisiae Annuae 15kg, semen Phaseoli Radiati extract 15kg, flos Lonicerae 14kg, herba Houttuyniae 18kg, radix Paeoniae Rubra 15kg, radix Rubiae extract 18kg and adjuvants 5kg.
In the embodiment, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 3:3:6:1.
In this embodiment, the method for extracting the madder extract includes the following steps:
s1, crushing radix rubiae to 100 meshes, adjusting the water content to 30%, and placing the crushed radix rubiae into a screw extruder for extrusion spraying treatment, wherein the extrusion spraying condition is that the extrusion temperature is 180 ℃, and the extrusion rotating speed is 150r/min to obtain the extruded radix rubiae;
s2, placing the extruded madder into distilled water, adjusting the pH to 5.5 by using citric acid, steaming for 5 hours, filtering and collecting filtrate A, adding distilled water into filter residues, adjusting the pH to 5.0 by using citric acid, continuously steaming for 5 hours, and filtering and collecting filtrate B;
and S3, combining the filtrate A and the filtrate B, steaming until the filtrate is 50ml, and drying to obtain the madder extract.
In this example, the extraction method of mung bean extract was the same as in example 1.
A preparation method of a veterinary Chinese medicinal granule preparation is the same as in example 1.
Example 6
A veterinary Chinese medicinal granule comprises herba Artemisiae Annuae 10kg, semen Phaseoli Radiati extract 10kg, flos Lonicerae 20kg, herba Houttuyniae 15kg, radix Paeoniae Rubra 20kg, radix Rubiae extract 20kg and adjuvants 5kg.
In the embodiment, the auxiliary materials comprise citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of the citric acid to the hydroxypropyl cellulose to the maltodextrin to the sucrose is 3:4:4:1.
In this example, the extraction method of the madder extract is the same as in example 1.
In this example, the extraction method of mung bean extract was the same as in example 1.
A preparation method of a veterinary Chinese medicinal granule preparation is the same as in example 1.
Test example 1 product stability
The stability of the product is inspected according to the operation method of the accelerated test and the long-term stability test of the veterinary drug stability test guidelines of the first edition of 2010 of the animal pharmacopoeia of the people's republic of China. See tables 1 and 2 for details.
TABLE 1 accelerated test results for the products prepared in example 1-example 6
TABLE 2 results of long-term stability test of the products obtained in example 1-example 6
In combination with tables 1 and 2, the products produced by the present invention did not change in appearance over a predetermined period of time under specific conditions of investigation by the acceleration test and the long-term test.
Test example 2 efficacy test
30 Rats with heat are selected and randomly divided into 3 groups, 10 rats in each group are marked as a test group, a comparison group and a blank group, wherein the test group is fed with the product prepared in the example 1 according to 5g/kg body weight, the comparison group is fed with aspirin according to 100mg/kg body weight, the blank group is fed with physiological saline according to 5g/kg body weight, the body temperature change trend of the rats is consistent after dry yeast injection, the temperature of each group is reduced and increased firstly, the body temperature of each group is not obviously different after 6 hours after heat generation, 3 hours before administration, the product has the same antipyretic effect as the comparison group, and the antipyretic effect of the product is stronger than that of the comparison group after administration for 3 hours.
Test example 3 efficacy test
Qualified piglets 120 are selected and randomly divided into 6 groups, namely a low-dose group in example 1, a medium-dose group in example 1, a high-dose group in example 1, an analgin control group, a positive control group and a blank control group, wherein each group is 20 heads, and each group (except the blank control group) is established with a method of LPS intraperitoneal injection to establish a heating model. And according to the established heating model, performing drug treatment after the body temperature rises stably. The low dose group, the medium dose group and the high dose group of the product are respectively infused with 0.25g/kg, 0.5g/kg and 1.0g/kg of body weight, and the administration is carried out for 3 days 1 time a day. The positive control group and the blank control group were filled with physiological saline at a volume of 1 mL/kg. The treatment results are shown in Table 3.
TABLE 3 curative effect results
| Group of | Invalidation of | Effective and effective | Has obvious effect | Healing |
| Blank control group | — | — | — | — |
| Positive control group | — | — | — | — |
| Analgin group | 0 | 3 | 6 | 11 |
| Example 1 Low dose group | 0 | 2 | 6 | 12 |
| Dose group in example 1 | 0 | 2 | 2 | 16 |
| Example 1 high dose group | 0 | 1 | 1 | 18 |
Wherein:
The clinical symptoms completely disappear after the medication, the spirit and the eating desire are recovered to be normal, and the cure rate is calculated by counting the cure number;
The clinical symptoms are obviously relieved after the medication, the patients with improved spirit and diet are treated, and the statistical effect number is calculated to obtain the effect;
the effective rate is the sum of cure rate and obvious efficiency;
The invalid condition is not improved after the symptoms are not disappeared after the treatment by the medicine, and the dead patients due to the disease are regarded as invalid during the treatment period, and the invalid number is counted, so that the calculation is inefficient.
As can be seen from Table 3, the low dose, medium dose and high dose groups of the product have obvious antipyretic effect on fever pigs.
Test example 4 Effect of Rubia cordifolia extract extraction Process on product efficacy
Test group example 1 and comparative group 1, the madder of comparative group 1 was not subjected to squeeze spray treatment during the extraction process. Otherwise, the same as in example 1 was conducted.
Test method the same as in test example 3.
The test results are shown in Table 4.
TABLE 4 curative effect results
| Group of | Invalidation of | Effective and effective | Has obvious effect | Healing |
| Blank control group | — | — | — | — |
| Positive control group | — | — | — | — |
| Analgin group | 0 | 3 | 6 | 11 |
| Example 1 Low dose group | 0 | 2 | 6 | 12 |
| Dose group in example 1 | 0 | 2 | 2 | 16 |
| Example 1 high dose group | 0 | 1 | 1 | 18 |
| Comparative group 1 Low dose group | 1 | 3 | 8 | 8 |
| Dose group in comparative group 1 | 0 | 3 | 4 | 13 |
| Comparative group 1 high dose group | 0 | 2 | 2 | 16 |
Referring to table 4, it can be seen that the extraction of the madder is performed after the extrusion spray treatment, so that the therapeutic effect of the product is improved, probably because the cells of the madder are broken after the extrusion spray treatment, the precipitation of the effective components is more facilitated in the extraction process, and the therapeutic effect of the product is further improved.
Test example 5 Effect of compatibility of sweet wormwood herb, mung bean extract and madder root extract on product efficacy
Test group 1, test group 1-test group 3, test group 1 did not contain mung bean extract and madder extract, test group 2 did not contain sweet wormwood and madder extract, test group 3 did not contain sweet wormwood and mung bean extract, otherwise, as in example 1.
Test method the same as in test example 3.
The test results are shown in Table 5.
TABLE 5 curative effect results
| Group of | Invalidation of | Effective and effective | Has obvious effect | Healing |
| Blank control group | — | — | — | — |
| Positive control group | — | — | — | — |
| Analgin group | 0 | 3 | 6 | 11 |
| Example 1 Low dose group | 0 | 2 | 6 | 12 |
| Dose group in example 1 | 0 | 2 | 2 | 16 |
| Example 1 high dose group | 0 | 1 | 1 | 18 |
| Test group 1 Low dose group | 1 | 3 | 7 | 9 |
| Dose group in test group 1 | 0 | 2 | 5 | 13 |
| Test group 1 high dose group | 0 | 2 | 3 | 15 |
| Test group 2 Low dose group | 1 | 2 | 6 | 12 |
| Dose group in test group 2 | 1 | 2 | 5 | 13 |
| Test group 2 high dose group | 0 | 1 | 4 | 15 |
| Test group 3 Low dose group | 1 | 3 | 5 | 12 |
| Dose group in test group 3 | 0 | 2 | 5 | 13 |
| Test group 3 high dose group | 0 | 1 | 4 | 15 |
Referring to Table 5, the products prepared in test group 1-test group 3 had weaker antipyretic effect on fever pigs than the product prepared in example 1, indicating synergistic effect of the ingredients, and were more favorable for antipyretic effect.
While the fundamental and principal features of the invention and advantages of the invention have been shown and described, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (10)
1. The veterinary traditional Chinese medicine granule preparation is characterized by comprising, by weight, 10-15 parts of sweet wormwood herb, 10-20 parts of mung bean extract, 10-15 parts of honeysuckle, 15-20 parts of cordate houttuynia, 15-20 parts of red paeony root, 15-20 parts of madder extract and the balance of auxiliary materials according to 100 parts.
2. The veterinary traditional Chinese medicine granule preparation as claimed in claim 1, wherein said adjuvant comprises citric acid, maltodextrin, sucrose and hydroxypropyl cellulose.
3. The veterinary traditional Chinese medicine granule preparation as claimed in claim 2, wherein the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 2-3:3-5:4-6:1.
4. A veterinary traditional Chinese medicine granule preparation as claimed in claim 3, wherein said extraction method of radix Rubiae extract comprises the steps of:
s1, crushing radix rubiae, adjusting the water content, and placing the crushed radix rubiae into a screw extruder for extrusion spraying treatment to obtain extruded radix rubiae;
S2, placing the extruded madder into distilled water, steaming for 1-5 hours, filtering and collecting filtrate A, adding distilled water into filter residues, continuously steaming for 1-5 hours, and filtering and collecting filtrate B;
S3, combining the filtrate A and the filtrate B, steaming until the filtrate is 20-50ml, and drying to obtain the madder extract.
5. The veterinary Chinese medicinal granule as claimed in claim 4, wherein in step S1, the granule diameter of radix Rubiae is 50-100 mesh, the water content is adjusted to 10% -30%, the extrusion spraying condition is extrusion temperature 150-180deg.C, and extrusion rotation speed is 150-200r/min.
6. A veterinary traditional Chinese medicine granule according to claim 5, wherein in step S2, the pH is adjusted to 5.0-5.5 with citric acid before each cooking.
7. The veterinary Chinese medicinal granule as claimed in claim 4, wherein the extraction method of semen Phaseoli Radiati extract comprises pulverizing semen Phaseoli Radiati to 100-150 mesh, adding 10-15 times of distilled water, decocting at 40-50deg.C for 2-5 hr, filtering, washing the residue, mixing filtrates, concentrating under reduced pressure to 20-50ml, adding 4-6 times of ethanol solution, standing overnight, filtering, collecting filtrate, concentrating, and drying to obtain semen Phaseoli Radiati extract.
8. A method for preparing a veterinary Chinese medicinal granule according to any one of claims 1 to 7, comprising the steps of:
Respectively weighing sweet wormwood, honeysuckle, cordate houttuynia and red paeony root, crushing, placing in an extraction tank, placing in 10-15 times of distilled water, extracting for 2-5 hours at low temperature in vacuum, filtering, taking filtrate, and continuously concentrating until the volume of the filtrate is half to obtain thick paste;
and step two, adding auxiliary materials into the thick paste, stirring for 0.5-1h, mixing and granulating by using a boiling drying granulator, and drying.
9. The method for preparing a veterinary Chinese medicinal granule according to claim 8, wherein the relative density of the soft extract is 1.25-1.30.
10. The method for preparing a veterinary Chinese medicinal granule as claimed in claim 9, wherein the particle size after granulation is 30-50 mesh.
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