CN119574653A - Sample analyzer and calibration method for electrolyte determination thereof - Google Patents
Sample analyzer and calibration method for electrolyte determination thereof Download PDFInfo
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- CN119574653A CN119574653A CN202311138304.XA CN202311138304A CN119574653A CN 119574653 A CN119574653 A CN 119574653A CN 202311138304 A CN202311138304 A CN 202311138304A CN 119574653 A CN119574653 A CN 119574653A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
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Abstract
本发明适用于体外诊断设备领域，公开了一种样本分析仪及样本分析仪中电解质测定的校准方法，该样本分析仪包括检测容器、第一样本分配组件、电极组件、排液组件和控制器，控制器被配置为执行如下校准动作：控制排液组件驱动目标离子浓度不同的至少三种校准液，分别流经电极组件并测得对应的第一测定参数，根据电极组件对至少三种校准液测得的至少三个第一测定参数，得到用于表征目标离子浓度与测定参数关系的校准结果；控制器还被配置为执行如下电解质测定动作：根据校准结果以及电极组件对待测液测得的第二测定参数，得到样本的目标离子测定结果。采用本发明的电解质测定的校准方案，可提高样本分析仪对样本进行电解质测定结果的准确性。
The present invention is applicable to the field of in vitro diagnostic equipment, and discloses a sample analyzer and a calibration method for electrolyte determination in the sample analyzer. The sample analyzer includes a detection container, a first sample distribution component, an electrode component, a drainage component and a controller, and the controller is configured to perform the following calibration actions: control the drainage component to drive at least three calibration liquids with different target ion concentrations to flow through the electrode component respectively and measure the corresponding first measurement parameters, and obtain a calibration result for characterizing the relationship between the target ion concentration and the measurement parameter according to the at least three first measurement parameters measured by the electrode component for the at least three calibration liquids; the controller is also configured to perform the following electrolyte measurement action: obtain the target ion measurement result of the sample according to the calibration result and the second measurement parameter measured by the electrode component for the test liquid. The calibration scheme for electrolyte determination of the present invention can improve the accuracy of the electrolyte measurement result of the sample analyzer on the sample.
Description
Technical Field
The invention relates to the field of in-vitro diagnostic equipment, in particular to a sample analyzer and a calibrating method for electrolyte measurement in the sample analyzer.
Background
In one sample analyzer provided in the related art, an electrolyte measurement module is provided, the electrolyte measurement module includes a detection container and an electrode assembly for performing electrolyte measurement on a liquid to be measured flowing out from the detection container. The electrolyte measurement module is typically calibrated prior to electrolyte measurement. In the related art, the calibration mode of the electrolyte measurement module is that a calibration solution prepared from two standard solutions with known target ion concentrations flows through an electrode assembly, measurement parameters of the electrode assembly when the two calibration solutions flow through the electrode assembly are measured, and a calibration result for representing the linear relation between the target ion concentration and the measurement parameters is obtained according to the measurement parameters measured by the two standard solutions. When the electrolyte of the sample is measured, the target ion measurement result of the sample can be obtained according to the measurement parameters and the calibration result measured by the electrode assembly.
For a part of samples, the calibration scheme of the related technology is adopted, the measurement results of the target ions obtained through calculation are more accurate, and for samples with the target ion concentration lower or higher than the concentration range of the two standard solutions, the measurement results of the target ions obtained through calculation according to the calibration results have larger deviation from the actual target ion concentration of the samples, namely the actual target ion concentration of the samples and the measurement parameters do not meet the linear relation between the target ion concentration and the measurement parameters in the calibration results, so that the accuracy of the measurement results of the target ions of the samples is seriously affected, and particularly, the measurement results are obviously shown on urine samples. Because the concentration distribution range of the target ions in the urine sample is wider than that of serum, the deviation of the measurement results of the target ions is larger.
Disclosure of Invention
A first object of the present invention is to provide a sample analyzer, which aims to solve the technical problem of large deviation of the measurement result of the target ions of the calculated part of the sample in the calibration result obtained by performing the electrolyte measurement calibration using two standard solutions in the related art.
In order to achieve the above object, the present invention provides a sample analyzer comprising:
a detection container having an inner cavity and a liquid drain port in communication with the inner cavity;
A first sample dispensing assembly for dispensing a sample into the lumen;
An electrode assembly for measuring target ions in a liquid to be measured which is discharged from the liquid discharge port and contains at least a sample;
A liquid discharge assembly for driving the liquid to be measured containing at least the sample to flow through the electrode assembly and for driving a calibration liquid containing at least a standard solution to flow through the electrode assembly;
The controller is configured to execute the following calibration actions, wherein the controller controls the liquid discharge assembly to drive at least three kinds of calibration liquids with different target ion concentrations to flow through the electrode assembly respectively and measure corresponding first measurement parameters, and according to the at least three first measurement parameters measured by the electrode assembly on the at least three kinds of calibration liquids, a calibration result used for representing the relation between the target ion concentration and the measurement parameters is obtained, and the calibration result comprises at least one of a calibration parameter, a calibration curve and a calibration relation;
the controller is further configured to perform an electrolyte measurement operation of controlling the liquid discharge assembly to drive the liquid to be measured, flowing through the electrode assembly from the detection container and obtaining a corresponding second measurement parameter, and obtaining a target ion measurement result of the sample according to the calibration result and the second measurement parameter measured by the electrode assembly for the liquid to be measured.
As one embodiment, the sample analyzer further comprises an internal standard liquid dispensing assembly for dispensing an internal standard liquid into the detection vessel;
the liquid discharging component is also used for driving a reference liquid at least containing the internal standard liquid to flow through the electrode component;
The controller controls the liquid discharging assembly to drive the calibration liquid to flow through the electrode assembly and measure the corresponding first measurement parameters, and comprises controlling the liquid discharging assembly to drive the calibration liquid and the reference liquid to flow through the electrode assembly and measure the corresponding first measurement parameters respectively;
The controller controls the liquid discharging assembly to drive the liquid to be measured to flow through the electrode assembly and obtain the corresponding second measurement parameters, and comprises controlling the liquid discharging assembly to drive the liquid to be measured and the reference liquid to flow through the electrode assembly respectively and measure the corresponding second measurement parameters.
As one embodiment, the first measurement parameter is a potential difference between the calibration fluid flowing through the electrode assembly and the reference fluid flowing through the electrode assembly;
The second measurement parameter is a potential difference between the liquid to be measured flowing through the electrode assembly and the reference liquid flowing through the electrode assembly.
As one embodiment, the at least three calibration liquids include a first calibration liquid including at least a first standard volume, a second calibration liquid including at least a second standard volume, and a third calibration liquid including at least a third standard volume, the first standard solution having a target ion concentration greater than the target ion concentration of the internal standard solution, the second standard solution having a target ion concentration less than the target ion concentration of the internal standard solution and greater than the target ion concentration of the third standard solution.
As an embodiment, the third standard solution and the calibration solution comprising at least the third standard solution are both diluents, and/or,
The difference between the target ion concentrations of the first standard solution and the second standard solution is greater than the difference between the target ion concentrations of the second standard solution and the third standard solution.
As one embodiment, the controlling the liquid discharge assembly to drive at least three kinds of calibration liquids with different target ion concentrations, respectively flowing through the electrode assembly and measuring corresponding first measurement parameters, and obtaining a calibration result for representing a relationship between the target ion concentration and the measurement parameters according to at least three first measurement parameters measured by the electrode assembly on the at least three kinds of calibration liquids, includes:
Controlling the liquid discharging assembly to drive the first calibration liquid and the reference liquid which at least comprise the first standard solution to flow through the electrode assembly respectively and measure a first potential difference, controlling the liquid discharging assembly to drive the second calibration liquid and the reference liquid which at least comprise the second standard solution to flow through the electrode assembly respectively and measure a second potential difference, controlling the liquid discharging assembly to drive the third calibration liquid and the reference liquid which at least comprise the third standard solution to flow through the electrode assembly respectively and measure a third potential difference, and obtaining the calibration result for representing the relation between the target ion concentration and the measured parameter at least according to the first potential difference, the second potential difference and the third potential difference.
As one embodiment, the at least three calibration fluids include a first calibration fluid comprising at least a first standard volume, a second calibration fluid comprising at least a second standard volume, a third calibration fluid comprising at least a third standard volume, and a fourth calibration fluid comprising at least a fourth standard volume, wherein the first standard solution has a target ion concentration greater than the target ion concentration of the internal standard solution and less than the target ion concentration of the fourth standard solution, and the second standard solution has a target ion concentration less than the target ion concentration of the internal standard solution and greater than the target ion concentration of the third standard solution, or
The at least three calibration liquids comprise a first calibration liquid at least comprising a first standard liquid, a second calibration liquid at least comprising a second standard liquid and a fourth calibration liquid at least comprising a fourth standard liquid, wherein the target ion concentration of the first standard liquid is greater than the target ion concentration of the internal standard liquid and less than the target ion concentration of the fourth standard liquid, and the target ion concentration of the second standard liquid is less than the target ion concentration of the internal standard liquid.
As one embodiment, the third standard solution and the third calibration solution comprising the third standard solution are both diluents, and/or,
The difference of the target ion concentrations of the first standard solution and the second standard solution is larger than the difference of the target ion concentrations of the second standard solution and the third standard solution, and the difference of the target ion concentrations of the first standard solution and the second standard solution is larger than the difference of the target ion concentrations of the fourth standard solution and the first standard solution.
As one embodiment, the sample analyzer further comprises a diluent dispensing assembly for dispensing a diluent into the detection container, the calibration solution is made of the standard solution and the diluent, the liquid to be measured is made of the sample and the diluent, and the reference solution is made of the internal standard solution and the diluent.
In one embodiment, the calibration result for representing the relation between the target ion concentration and the measurement parameters is obtained according to at least three first measurement parameters measured by the electrode assembly on the at least three calibration liquids, and the calibration result comprises at least one calibration result which is obtained according to two first measurement parameters measured by the electrode assembly on any two adjacent calibration liquids of the target ion concentration, a set of calibration parameters, a calibration straight line and a calibration relation.
In one embodiment, the electrode assembly is used for measuring at least two target ions of the liquid to be measured or the calibration liquid, the calibration result for representing the relationship between the target ion concentration and the measurement parameter is obtained according to at least three first measurement parameters measured by the electrode assembly on the at least three calibration liquids, the calibration result comprises that at least two groups of calibration parameters for representing the linear function of the relationship between the target ion concentration and the measurement parameter are obtained according to at least three first measurement parameters measured by the electrode assembly on the at least three calibration liquids, each group of calibration parameters comprises a calibration slope and a calibration intercept for representing the linear function of the relationship between the target ion concentration and the measurement parameter, the calibration slope and the calibration intercept of each group of calibration parameters are obtained according to two first measurement parameters measured by two calibration liquids adjacent to the target ion concentration, the two calibration slopes of each group of calibration parameters are different, and/or,
The electrode assembly is used for measuring at least two target ions of the liquid to be measured or the calibration liquid, and the calibrating result used for representing the relation between the concentration of the target ions and the measuring parameters is obtained according to at least three first measuring parameters measured by the electrode assembly on the at least three calibration liquids, and comprises the following steps: according to at least three first measurement parameters measured by the electrode assembly on the at least three calibration liquids, corresponding to each target ion, obtaining at least two calibration straight lines used for representing the relation between the concentration of the target ion and the measurement parameters, wherein the at least two calibration straight lines obtained by each target ion are sequentially connected and have different slopes, and each calibration straight line is obtained by two first measurement parameters measured by two calibration liquids with adjacent target ion concentrations.
As one implementation mode, the sample analyzer pre-stores at least one preset condition that a first preset time length after the sample analyzer is started up is reached, a second preset time length is reached after the calibration working mode is executed last time, the time length of the sample analyzer for continuously executing the electrolyte measuring working mode is reached to a third preset time length, the time length of the sample analyzer for accumulating the electrolyte measuring working mode to reach a fourth preset time length after the calibration working mode is executed last time, the times of the sample analyzer for continuously executing the electrolyte measuring working mode is reached to a first preset times, the times of the sample analyzer for accumulating the electrolyte measuring working mode to reach a second preset times after the calibration working mode is executed last time, and a preset time point of a preset period is reached, wherein the preset period is daily or every two days or every four days or every five days or every week;
the controller is further configured to perform the calibration action when any one of the preset conditions is met.
As one embodiment, the sample analyzer further comprises a standard solution dispensing assembly for dispensing the standard solution into the detection vessel, the standard solution dispensing assembly being the same assembly as the first sample dispensing assembly or being two independent assemblies, and/or,
The electrode assembly comprises at least one ion selective electrode and a reference electrode, the liquid draining assembly drives the liquid to be detected in the detection container to flow through the electrode assembly comprises drives the liquid to be detected in the detection container to sequentially flow through the ion selective electrode and the reference electrode, the liquid draining assembly drives the calibration liquid to flow through the electrode assembly comprises drives the calibration liquid in the detection container to sequentially flow through the ion selective electrode and the reference electrode, and the at least one ion selective electrode comprises at least one of a sodium ion selective electrode, a chloride ion selective electrode and a potassium ion selective electrode.
As one embodiment, the sample analyzer further comprises a reagent dispensing assembly for aspirating a sample from a sample container for dispensing to a reaction container, a second sample dispensing assembly for aspirating a reagent from a reagent container for dispensing to the reaction container, and at least one optical assay assembly for optically assaying at least the sample dispensed by the second sample dispensing assembly and a reaction solution made of the reagent dispensed by the reagent dispensing assembly;
the at least one optical assay component comprises at least one of a biochemical assay component, an immunoassay component, a clotting assay component;
Wherein the second sample distribution component and the first sample distribution component are the same component or two different components.
A second object of the present invention is to provide a method for calibrating electrolyte measurement in a sample analyzer, the method comprising the steps of:
controlling the liquid discharge assembly to drive at least three calibration liquids with different target ion concentrations to flow through the electrode assembly respectively and measuring corresponding first measurement parameters;
and obtaining a calibration result for representing the relation between the target ion concentration and the measurement parameters according to at least three first measurement parameters measured by the at least three calibration liquids, wherein the calibration result comprises at least one of calibration parameters, calibration curves and calibration relations.
As one embodiment, the controlling the liquid discharging assembly to drive at least three calibration liquids with different target ion concentrations respectively flows through the electrode assembly and measures corresponding first measurement parameters, including:
Controlling the liquid discharging assembly to drive the first calibration liquid at least containing a first standard solution and the reference liquid at least containing an internal standard solution to flow through the electrode assembly respectively and measure a first potential difference, controlling the liquid discharging assembly to drive the second calibration liquid at least containing a second standard solution and the reference liquid at least containing an internal standard solution to flow through the electrode assembly respectively and measure a second potential difference, and controlling the liquid discharging assembly to drive the third calibration liquid at least containing a third standard solution and the reference liquid at least containing an internal standard solution to flow through the electrode assembly respectively and measure a third potential difference.
As an embodiment, the third standard solution and the calibration solution comprising at least the third standard solution are both diluents, and/or,
The target ion concentration of the first standard solution is greater than the target ion concentration of the internal standard solution, and the target ion concentration of the second standard solution is less than the target ion concentration of the internal standard solution and greater than the target ion concentration of the third standard solution.
According to the sample analyzer and the calibration method for electrolyte measurement in the sample analyzer, at least three kinds of calibration liquids with different target ion concentrations are adopted for calibrating the electrolyte measurement, namely, the calibration of adding at least one kind of calibration liquid for calibrating the electrolyte measurement on the basis of a calibration scheme of the related technology is equivalent, so that a calibration result with a wider target ion concentration range is obtained, the calibration result can be used for accurately measuring the target ion concentration of more samples, and the accuracy of the electrolyte measurement result of the sample analyzer on different samples is ensured.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic liquid path diagram of an electrolyte measurement section of a sample analyzer according to an embodiment of the present invention.
The reference numerals illustrate 10, a sample analyzer, 100, an electrode assembly, 110, an ion selective electrode, 120, a reference electrode, 200, a detection container, 300, a liquid discharge assembly, 310, a liquid discharge power part, 320, a waste liquid channel, 400, a first sample distribution assembly, 410, a first sample needle, 500, a diluent distribution assembly and 600, an internal standard liquid distribution assembly.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that all directional indicators (such as up, down, left, right, front, and rear) in the embodiments of the present invention are merely used to explain the relative positional relationship between the components, the movement condition, and the like in a certain specific posture, and if the specific posture is changed, the directional indicator is changed accordingly.
It will also be understood that when an element is referred to as being "mounted" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be indirectly connected to the other element through intervening elements.
Furthermore, the description of "first," "second," etc. in this disclosure is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.
Embodiment one:
as shown in fig. 1, a sample analyzer 10 according to a first embodiment of the present invention includes an electrode assembly 100 and a detection container 200, where the electrode assembly 100 is configured to measure target ions (i.e., electrolyte measurement, which is mainly performed to measure a target ion concentration in a liquid to be measured) from the liquid to be measured flowing out of the detection container 200, and the liquid to be measured at least includes a sample.
In one embodiment, the test container 200 has an inner cavity and a drain port in communication with the inner cavity for allowing a fluid to be tested to flow from the inner cavity to the electrode assembly 100. The inner cavity is used for providing a containing place for the sample and the liquid to be tested. The electrode assembly 100 is used for measuring target ions in a liquid to be measured which is discharged from a liquid discharge port and contains at least a sample.
In one embodiment, the sample analyzer 10 further includes a drain assembly 300, the drain assembly 300 being configured to drive a liquid through the electrode assembly 100, i.e., the drain assembly 300 being configured to provide a driving force for the liquid to flow through the electrode assembly 100. In this embodiment, the liquid discharge assembly 300 is used for driving a liquid to be measured containing at least a sample to flow through the electrode assembly 100 and for driving a calibration liquid containing at least a standard solution to flow through the electrode assembly 100.
As one embodiment, the sample analyzer 10 further includes a first sample dispensing assembly 400, the first sample dispensing assembly 400 for dispensing a sample into the interior cavity of the test receptacle 200. The first sample dispensing assembly 400 is primarily used to effect the dispensing of a sample. The first sample dispensing assembly 400 injects the sample into the test receptacle 200 by dispensing.
As one embodiment, the sample analyzer 10 further comprises a controller electrically connected to at least one of the electrode assembly 100, the drain assembly 300, and the first sample dispensing assembly 400.
As one embodiment, the controller is electrically connected to the electrode assembly 100, the drain assembly 300, and the first sample distribution assembly 400, respectively. The controller is used for controlling the liquid discharging assembly 300 and the first sample distributing assembly 400 to work, and is used for obtaining a target ion measuring result of a sample according to the electric parameters of the electrode assembly 100 when the liquid to be measured flows through the electrode assembly 100.
As one embodiment, the controller is configured to perform a calibration operation of controlling the liquid discharge assembly 300 to drive at least three kinds of calibration liquids with different target ion concentrations, respectively flowing through the electrode assembly 100 and measuring corresponding first measurement parameters, and obtaining a calibration result for representing the relationship between the target ion concentration and the measurement parameters according to at least three first measurement parameters measured by the electrode assembly 100, wherein the calibration result comprises at least one of a calibration parameter, a calibration curve and a calibration relation. The controller is further configured to perform an electrolyte measurement operation of controlling the liquid discharge assembly 300 to drive the liquid to be measured, flowing through the electrode assembly 100 from the detection container 200 and obtaining a corresponding second measurement parameter, and obtaining a target ion measurement result of the sample according to the calibration result and the second measurement parameter measured by the electrode assembly 100 for the liquid to be measured. The calibration operation of electrolyte measurement, also called as calibration operation of electrolyte measurement, is mainly used for determining the relation of the target ion concentration and the measurement parameter. In this embodiment, at least three calibration solutions with different target ion concentrations are used for calibrating the electrolyte measurement, which is favorable for obtaining a calibration result with a wider target ion concentration range, so that the calibration result can be used for accurately measuring the target ion concentration of more samples, and the accuracy of the electrolyte measurement result of the sample analyzer 10 for different samples is ensured.
As an embodiment, the electrode assembly 100 includes a reference electrode 120 and at least one ion-selective electrode 110, the liquid discharge assembly 300 driving the liquid to be measured in the detection vessel 200 to flow through the electrode assembly 100 includes driving the liquid to be measured in the detection vessel 200 to flow through the ion-selective electrode 110 and the reference electrode 120 in sequence, the liquid discharge assembly 300 driving the calibration liquid to flow through the electrode assembly 100 includes driving the calibration liquid in the detection vessel 200 to flow through the ion-selective electrode 110 and the reference electrode 120 in sequence, and the at least one ion-selective electrode 110 includes at least one of a sodium ion-selective electrode 110, a chloride ion-selective electrode 110, and a potassium ion-selective electrode 110. In this embodiment, the ion selective electrode 110 and the reference electrode 120 are arranged side by side, and the measurement parameter is obtained by sequentially flowing the liquid to be measured through the ion selective electrode 110 and the reference electrode 120. Of course, the arrangement of the electrode assembly 100 is not limited thereto in a specific application.
As one embodiment, the electrode assembly 100 includes a reference electrode 120, a sodium ion selective electrode 110, a chloride ion selective electrode 110, a potassium ion selective electrode 110. In this embodiment, the sodium ion concentration, the chloride ion concentration, and the potassium ion concentration can be measured for the sample.
As one embodiment, the electrode assembly 100 further includes a measurement channel through which the drain communicates with the drain assembly 300. The reference electrode 120 and the ion-selective electrode 110 are both at least partially disposed through the measurement channel such that liquid flowing through the measurement channel can contact the reference electrode 120 and the ion-selective electrode 110.
As one embodiment, the liquid draining assembly 300 includes a liquid draining power part 310 and a liquid waste channel 320, wherein the liquid draining power part 310 is used for driving the liquid in the inner cavity of the detection container 200 to sequentially flow through the liquid draining port and the electrode assembly 100 and then be discharged to the liquid waste channel 320. The liquid discharge power part 310 is mainly used for providing driving force for liquid in the detection container 200 to flow out of the liquid discharge port and flow through the electrode assembly 100. The waste liquid channel 320 communicates with a waste liquid collecting container for discharging the liquid discharged through the liquid discharge power part 310 to the waste liquid collecting container.
As one embodiment, the sample is serum or plasma or urine or other body fluids. After the sample is collected from the patient, it is stored in a sample container, and the first sample dispensing assembly 400 is configured to aspirate the sample from the sample container and dispense at least a portion of the aspirated sample into the test container 200. The sample container is provided with an identification code, and the identification code comprises at least one of a bar code, a two-dimensional code and a wireless radio frequency code.
In one embodiment, the first sample dispensing assembly 400 includes a first sample needle 410, a first motion driving component and a first pipetting driving component, where the first motion driving component is configured to drive the first sample needle 410 to perform a two-dimensional or three-dimensional spatial motion, so as to move the first sample needle 410 to different stations, such as a standby station, a pipetting station, a loading station, a washing station, and the like. The first pipetting and drainage driving unit is configured to drive the first sample needle 410 to perform pipetting and drainage operations.
As one embodiment, the sample analyzer 10 further includes a standard solution dispensing assembly for dispensing a standard solution into the test container 200.
As an embodiment, the standard solution dispensing assembly is the same assembly as the first sample dispensing assembly 400, i.e., the first sample dispensing assembly 400 is multiplexed to dispense standard solution in addition to being used to dispense samples, which is beneficial to reduce the cost of the sample analyzer 10. Of course, in a specific application, the standard solution dispensing assembly and the first sample dispensing assembly 400 may be two separate assemblies as an alternative embodiment.
As an embodiment, the sample is loaded in a sample container, which is transported by a sample rack or sample holder to the first sample suction site. The standard solution is loaded in a standard solution container, and the standard solution container is conveyed to the second sample sucking position through a standard solution frame. The first sample sucking position and the second sample sucking position can be the same position or two different positions. The sample rack and the standard solution rack are two different rack bodies, and can also be the same rack body. The first sample dispensing assembly 400 is for aspirating a sample from a sample container at a first sample aspirating position into the test container 200 and for aspirating a standard solution from a standard solution container at a second sample aspirating position into the test container 200.
As one embodiment, the sample analyzer 10 further includes an internal standard fluid dispensing assembly 600, the internal standard fluid dispensing assembly 600 being configured to dispense an internal standard fluid into the test receptacle 200. The drain assembly 300 is also used to drive a reference liquid containing at least an internal standard liquid through the electrode assembly 100. The controller controls the liquid discharging assembly 300 to drive a calibration liquid to flow through the electrode assembly 100 and measure a corresponding first measurement parameter, and includes controlling the liquid discharging assembly 300 to drive a calibration liquid and a reference liquid to flow through the electrode assembly 100 and measure a corresponding first measurement parameter, respectively. The controller controls the liquid discharging assembly 300 to drive the liquid to be measured to flow through the electrode assembly 100 and obtain the corresponding second measurement parameters, and includes controlling the liquid discharging assembly 300 to drive the liquid to be measured and the reference liquid to flow through the electrode assembly 100 respectively and measure the corresponding second measurement parameters. The internal standard solution is a solution having a known target ion concentration and disposed inside the sample analyzer 10. The concentration of target ions in the internal standard solution will be closer to the concentration of target ions in normal human serum than in the standard solution. In this embodiment, when the second measurement parameter obtained by performing the electrolyte measurement is obtained by calculating the electrical parameter of the electrode assembly 100 when the solution to be measured and the reference solution respectively flow through the electrode assembly 100, the measurement result of the electrolyte of the sample can be more accurate, and the measurement speed is faster. Since the second measurement parameter is obtained by flowing the reference liquid containing the internal standard liquid through the electrode assembly 100 in the electrolyte measurement of the sample, in order to obtain the calibration result for representing the relationship between the target ion concentration and the measurement parameter by calibration, the correspondence between the target ion concentration and the measurement parameter used in the electrolyte measurement is obtained, so that the first measurement parameter obtained in the calibration process is obtained by calculating according to the electrical parameter of the electrode assembly 100 when the calibration liquid and the reference liquid respectively flow through the electrode assembly 100. Of course, in particular applications, alternative embodiments, the electrolyte determination and calibration may be performed without the need for a reference fluid containing an internal standard fluid to flow through the electrode assembly 100.
As one embodiment, the internal standard solution dispensing assembly 600 includes an internal standard solution needle and a second liquid suction and discharge drive member. The second liquid sucking and discharging driving part is used for driving the internal standard liquid needle to perform liquid sucking action and liquid discharging action. The internal standard liquid needle is connected to the frame body of the detection container 200 through a connecting seat. The internal standard liquid needle is not movable.
As an embodiment, the sample analyzer 10 further includes a diluent distribution assembly 500, where the diluent distribution assembly 500 is configured to distribute a diluent into the detection container 200, the calibration solution is made of a standard solution and the diluent, the sample to be measured is made of a sample and the diluent, and the reference solution is made of an internal standard solution and the diluent. In this embodiment, when the electrolyte is measured, the sample is diluted with the diluent to obtain the liquid to be measured, and the concentration of the target ion in the sample is measured by the indirect method, which has the advantages of consuming a small amount of sample and reducing the influence of substances such as protein and lipid in the sample on the measurement result. Of course, in a specific application, the test solution may also contain only the sample, and no diluent, as an alternative embodiment.
As one embodiment, the diluent dispensing assembly 500 includes a diluent needle that is connected to the testing container 200 via a connector. The diluent needle is not movable.
As one embodiment, the first measurement parameter is the potential difference between the calibration fluid flowing through the electrode assembly 100 and the reference fluid flowing through the electrode assembly 100, and the second measurement parameter is the potential difference between the fluid to be measured flowing through the electrode assembly 100 and the reference fluid flowing through the electrode assembly 100. The first measurement parameter and the second measurement parameter adopt potential difference, and are easy to realize.
As one embodiment, the at least three calibration fluids include a first calibration fluid comprising at least a first standard volume, a second calibration fluid comprising at least a second standard volume, and a third calibration fluid comprising at least a third standard volume, the first standard solution having a target ion concentration greater than the target ion concentration of the internal standard solution, the second standard solution having a target ion concentration less than the target ion concentration of the internal standard solution and greater than the target ion concentration of the third standard solution. The first standard solution is a standard solution with larger target ion concentration, the second standard solution is a standard solution with smaller target ion concentration, the third standard solution and the second standard solution are standard solutions with smaller target ion concentration than the internal standard solution, and the third standard solution is a standard solution with smaller target ion concentration than the second standard solution. According to the embodiment, the low-value third standard solution with smaller target ion concentration is additionally arranged on the basis of the first standard solution and the second standard solution to calibrate the electrolyte measurement, so that the target ion measurement result of a sample with the target ion concentration smaller than the concentration range of the first standard solution and the second standard solution can be reduced, and the accuracy of the electrolyte measurement result of a sample with the small target ion concentration can be improved.
In one embodiment, the third standard solution is a diluent, and the calibration solution including at least the third standard solution is also a diluent. The target ion concentration of the diluent is very low and known, the diluent is adopted as the standard solution with low target ion concentration, on one hand, a distribution component of a third standard solution is not required to be additionally arranged, on the other hand, the diluent is adopted for calibration, and the calibration is close to zero point calibration, so that the calibrated target ion concentration range is effectively enlarged, a sample with small target ion concentration also has an applicable calibration coefficient, and the accuracy and the linearity of the electrolyte measurement result of the sample with small target ion concentration are fully ensured.
As one implementation mode, the difference value of the target ion concentration of the first standard solution and the second standard solution is larger than that of the second standard solution and the third standard solution, the determined target ion concentration range of the first standard solution and the second standard solution is larger, and accurate electrolyte determination results can be obtained by determining the calibration results by fully ensuring samples with larger target ion concentration ranges.
As one embodiment, the controlling the liquid discharging assembly 300 to drive at least three calibration liquids with different target ion concentrations, respectively flowing through the electrode assembly 100 and measuring corresponding first measurement parameters, and obtaining calibration results for representing the relationship between the target ion concentration and the measurement parameters according to at least three first measurement parameters measured by the electrode assembly 100 for the at least three calibration liquids comprises: the liquid discharging assembly 300 is controlled to drive a first calibration liquid and a reference liquid which at least comprise a first standard solution to flow through the electrode assembly 100 respectively and measure a first potential difference, the liquid discharging assembly 300 is controlled to drive a second calibration liquid and a reference liquid which at least comprise a second standard solution to flow through the electrode assembly 100 respectively and measure a second potential difference, the liquid discharging assembly 300 is controlled to drive a third calibration liquid and a reference liquid which at least comprise a third standard solution to flow through the electrode assembly 100 respectively and measure a third potential difference, and a calibration result for representing the relation between the target ion concentration and the measured parameter is obtained at least according to the first potential difference, the second potential difference and the third potential difference. In this embodiment, when an electrolyte is measured and calibrated by using one standard solution, the potential difference is obtained by matching with the measurement of the internal standard solution, which is beneficial to ensuring the accuracy of the calibration result.
In one embodiment, the calibration results for representing the relationship between the target ion concentration and the measurement parameters are obtained according to at least three first measurement parameters measured by the electrode assembly 100 for at least three calibration liquids, and the calibration results comprise at least one calibration result, namely a group of calibration parameters, a calibration straight line and a calibration relational expression, obtained according to two first measurement parameters measured by the electrode assembly 100 for any two adjacent calibration liquids for the target ion concentration. In this embodiment, two calibration solutions with similar concentrations of any two target ions are used as two points to obtain a calibration result, so that samples in different concentration ranges can be respectively calculated by using different calibration results to calculate the measurement result of the target ions, thereby being beneficial to ensuring that samples in different concentration ranges of the target ions can obtain more accurate measurement results.
As one embodiment, the electrode assembly 100 is used for measuring at least two target ions of a liquid to be measured or a calibration liquid, and the calibration result for representing the relationship between the concentration of the target ions and the measurement parameters is obtained according to at least three first measurement parameters measured by the electrode assembly 100 for at least three calibration liquids, and comprises, corresponding to each target ion, obtaining at least two sets of calibration parameters for representing a linear function of the relationship between the concentration of the target ions and the measurement parameters, wherein each set of calibration parameters comprises a calibration slope and a calibration intercept for representing a linear function of the relationship between the concentration of the target ions and the measurement parameters, the calibration slope and the calibration intercept in each set of calibration parameters are obtained by two first measurement parameters measured by two calibration liquids adjacent to the concentration of the target ions, and the two calibration slopes of each set of calibration parameters are different. The target ion concentration and the measurement parameter satisfy the following linear function y=kx+b, where y is the measurement parameter, x is the target ion concentration, k is the slope, and b is the intercept. The calibration action is mainly to calibrate the slope k and intercept b in the resulting primary function. In this embodiment, the calibration slope and the calibration intercept of at least two functions can be obtained for each target ion concentration, each function representing the relationship between the target ion concentration and the measurement parameter over the interval.
In the above-mentioned scheme, the calibration result of each target ion measurement is the calibration slope and the calibration intercept of at least two linear functions, and of course, in specific applications, the calibration result is not limited thereto, for example, as an alternative embodiment, the calibration result of each target ion measurement may also be a calibration curve formed by splicing at least two calibration straight lines. Specifically, in this alternative embodiment, the electrode assembly 100 is configured to measure at least two target ions of a solution to be measured or a calibration solution, and obtain a calibration result for characterizing a relationship between a target ion concentration and a measurement parameter according to at least three first measurement parameters measured by the electrode assembly 100 for at least three calibration solutions, where the calibration result includes obtaining at least two calibration straight lines for characterizing the relationship between the target ion concentration and the measurement parameter according to at least three first measurement parameters measured by the electrode assembly 100 for at least three calibration solutions, where the at least two calibration straight lines obtained for each target ion are sequentially connected and have different slopes, and each calibration straight line is obtained from two first measurement parameters measured by two calibration solutions adjacent to the target ion concentration.
As one embodiment, the sample analyzer 10 pre-stores at least one preset condition that a first preset time period after the sample analyzer 10 is started up is reached, a second preset time period is reached since the calibration operation mode is executed last time, a third preset time period is reached since the sample analyzer 10 continuously executes the electrolyte measurement operation mode, a fourth preset time period is reached since the sample analyzer 10 accumulates the time of executing the electrolyte measurement operation mode after the calibration operation mode is executed last time, a first preset number of times is reached since the sample analyzer 10 continuously executes the electrolyte measurement operation mode, a second preset number of times is reached since the sample analyzer 10 accumulates the time of executing the electrolyte measurement operation mode after the calibration operation mode is executed last time, and a preset time point of a preset period is reached. The controller is further configured to perform a calibration action when any one of the preset conditions is met. In this embodiment, the calibration action of the electrolyte measurement does not occupy the time of the electrolyte measurement, and is automatically executed according to a set program when the preset condition is satisfied, so that the operation personnel is basically insensitive to the calibration action process of the electrolyte measurement, and the interference of the calibration action process of the electrolyte measurement to the operation personnel is greatly reduced.
As one embodiment, the preset period is daily or every two days or every three days or every four days or every five days or every week.
As one embodiment, the sample analyzer 10 further comprises a reagent dispensing assembly for drawing a sample from a sample container into a reaction container, a reagent dispensing assembly for drawing a reagent from a reagent container into a reaction container, and at least one optical measurement assembly for optically measuring a reaction solution made of at least the sample dispensed by the second sample dispensing assembly and the reagent dispensed by the reagent dispensing assembly, wherein the at least one optical measurement assembly comprises at least one of a biochemical measurement assembly, an immunoassay assembly, and a coagulation measurement assembly, and wherein the second sample dispensing assembly is the same assembly as the first sample dispensing assembly 400 or is two different assemblies. In this embodiment, the sample analyzer 10 integrates at least one of a biochemical measurement function, an immunoassay function, and a blood coagulation measurement function in addition to the electrolyte measurement function, that is, the electrolyte measurement module may be integrated in the biochemical analyzer or the immunoassay analyzer or the blood coagulation analyzer, which is advantageous in diversifying the functions of the sample analyzer 10. Of course, in particular applications, the sample analyzer 10 may have only an electrolyte measuring function as an alternative embodiment, i.e., the sample analyzer 10 may be a stand-alone electrolyte measuring unit.
In one embodiment, the sample analyzer 10 is a biochemical analyzer integrated with an electrolyte measurement.
The embodiment also provides a calibration method for measuring the electrolyte in the sample analyzer 10, which comprises the following steps of controlling the liquid discharge assembly 300 to drive at least three calibration liquids with different target ion concentrations to flow through the electrode assembly 100 respectively and measure corresponding first measurement parameters, and obtaining a calibration result for representing the relationship between the target ion concentration and the measurement parameters according to the at least three first measurement parameters measured by the at least three calibration liquids, wherein the calibration result comprises at least one of the calibration parameters, a calibration curve and a calibration relation. The embodiment expands the calibration concentration range, leads the low concentration sample to have a proper calibration result, and improves the accuracy and the linearity of the electrolyte measurement result of the low concentration sample.
In one embodiment, controlling the liquid discharge assembly 300 to drive at least three calibration liquids with different target ion concentrations to flow through the electrode assembly 100 and measure corresponding first measurement parameters respectively includes controlling the liquid discharge assembly 300 to drive at least a first calibration liquid containing a first standard solution and at least a reference liquid containing an internal standard solution to flow through the electrode assembly 100 and measure a first potential difference respectively, controlling the liquid discharge assembly 300 to drive at least a second calibration liquid containing a second standard solution and at least a reference liquid containing an internal standard solution to flow through the electrode assembly 100 and measure a second potential difference respectively, and controlling the liquid discharge assembly 300 to drive at least a third calibration liquid containing a third standard solution and at least a reference liquid containing an internal standard solution to flow through the electrode assembly 100 and measure a third potential difference respectively.
As one embodiment, the third standard solution and the calibration solution including at least the third standard solution are both dilutions.
As one embodiment, the target ion concentration of the first standard solution is greater than the target ion concentration of the internal standard solution, and the target ion concentration of the second standard solution is less than the target ion concentration of the internal standard solution and greater than the target ion concentration of the third standard solution.
The specific principles and implementation of the calibration method for electrolyte measurement in the sample analyzer 10 provided in this embodiment are similar to those described in the sample analyzer 10, and will not be described in detail herein.
The present embodiment also provides a computer-readable storage medium storing a computer program which, when executed by a processor (e.g., the controller described above), causes the processor to implement the steps of the method for calibrating electrolyte measurement in the sample analyzer 10 described above. The computer readable storage medium may be an internal storage unit of the sample analyzer 10, such as a hard disk or a memory of the sample analyzer 10, or an external storage device of the sample analyzer 10, such as a plug-in hard disk, a smart memory card (SMART MEDIA CARD, SMC), a Secure Digital (SD) card, a flash memory card (FLASH CARD) or the like, which are provided on the sample analyzer 10.
As one embodiment, the principles of the sample analyzer 10 include:
(1) When the ion selective electrode method (indirect method) is used for measuring the target ion concentration in a serum sample or a plasma sample or a urine sample, for example, na +/K+/Cl- project is measured, the sample and the diluent are mixed in a certain dilution ratio, when the mixed liquid to be measured flows through the ion selective electrode 110 and the reference electrode 120, the target ions can be subjected to ion exchange and diffusion on the electrode film material due to the characteristics of the electrode film, the potential difference is formed by the ion selective electrode 110 of Na +/K+/Cl- and the reference electrode 120, the response intensity of the film potential is related to the concentration of the target ions, the higher the target ion concentration is, the greater the film potential is, the relation between the potential of the ion selective electrode 110 of Na +/K+/Cl- and the ion concentration of corresponding Na +/K+/Cl- in the sample is in accordance with Nernst equation, the potential difference between the potential of the liquid to be measured and the reference liquid is obtained according to the measurement, and the concentration of the target ions in the sample can be calculated through the potential difference.
(2) In order to make the electrolyte measurement result of the sample lower than the concentration ranges of the first standard solution and the second standard solution more accurate, the embodiment provides a calibration method for increasing zero point calibration, namely, a calibration point with very low concentration (the concentration is lower than the linear range of the target ion item) is added on the basis of the first standard solution and the second standard solution, so that the target ion concentration range applicable to the calibration result is enlarged, the low target ion concentration sample has an applicable calibration curve, and the accuracy and the linearity of the measurement result of the low concentration sample are improved. Because the target ion concentration of the diluent is low and known, the diluent is used as the zero point scale. In the specific embodiment, one additional measurement of the diluent is added to the calibration flow of the first standard solution and the second standard solution. According to the target ion concentration and the measurement parameters measured by the diluent and the measurement parameters measured by the second standard solution, a calibration curve suitable for a low-concentration sample is obtained, so that a more accurate result can be obtained for the low-concentration sample. Each time the calibration is performed, the electrolyte module measures the first standard solution, the second standard solution and the diluent to obtain a standard first calibration line and a low value section second calibration line (or obtain the slope and intercept of the first calibration line and the second calibration line). In sample measurement, a corresponding calibration straight line (or a slope and an intercept of the corresponding calibration straight line) is selected based on the measured potential difference, and a measurement result of the target ion is calculated. According to the invention, a zero point calibration is added on the basis of the existing calibration flow, the calibration concentration range is enlarged, a low concentration sample has an applicable calibration curve, and the accuracy and linearity of the low concentration sample result are improved.
Embodiment two:
The sample analyzer 10 and the method for calibrating the electrolyte measurement in the sample analyzer 10 provided in this embodiment are different from the first embodiment mainly in that the standard solution is adopted in the calibration process, and specifically include that in the first embodiment, the electrolyte measurement is calibrated by further adding a low-value third standard solution with smaller target ion concentration based on the first standard solution and the second standard solution, and in this embodiment, the electrolyte measurement is calibrated by further adding a low-value third standard solution with smaller target ion concentration and a fourth standard solution with larger target ion concentration based on the first standard solution and the second standard solution.
Specifically, in this embodiment, the at least three calibration liquids include a first calibration liquid including at least a first standard solution, a second calibration liquid including at least a second standard solution, a third calibration liquid including at least a third standard solution, and a fourth calibration liquid including at least a fourth standard solution, where the target ion concentration of the first standard solution is greater than the target ion concentration of the internal standard solution and less than the target ion concentration of the fourth standard solution, and the target ion concentration of the second standard solution is less than the target ion concentration of the internal standard solution and greater than the target ion concentration of the third standard solution. The embodiment can lead the samples with smaller target ion concentration and larger target ion concentration to have the applicable calibration coefficients, and fully ensures the accuracy and linearity of the electrolyte measurement results of the samples with smaller target ion concentration and the samples with larger target ion concentration.
As one embodiment, the third standard solution and the third calibration solution prepared by the third standard solution are all diluted solutions.
As one embodiment, the difference in target ion concentration between the first standard solution and the second standard solution is greater than the difference in target ion concentration between the second standard solution and the third standard solution, and the difference in target ion concentration between the first standard solution and the second standard solution is greater than the difference in target ion concentration between the fourth standard solution and the first standard solution.
In addition to the above differences, the sample analyzer 10 and other parts of the calibration method for electrolyte measurement in the sample analyzer 10 provided in this embodiment can refer to the first embodiment, and will not be described in detail herein.
Embodiment III:
The sample analyzer 10 and the method for calibrating the electrolyte measurement in the sample analyzer 10 provided in this embodiment are different from the first embodiment mainly in that the standard solution is adopted in the calibration process, and specifically include that in the first embodiment, the electrolyte measurement is calibrated by further adding a low-value third standard solution with smaller target ion concentration on the basis of the first standard solution and the second standard solution, and in the embodiment, the electrolyte measurement is calibrated by further adding a fourth standard solution with larger target ion concentration on the basis of the first standard solution and the second standard solution.
Specifically, in this embodiment, the at least three calibration liquids include a first calibration liquid including at least a first standard solution, a second calibration liquid including at least a second standard solution, and a fourth calibration liquid including at least a fourth standard solution, where the target ion concentration of the first standard solution is greater than the target ion concentration of the internal standard solution and less than the target ion concentration of the fourth standard solution, and the target ion concentration of the second standard solution is less than the target ion concentration of the internal standard solution. The embodiment can enable the sample with larger target ion concentration to have an applicable calibration coefficient, and fully ensures the accuracy and linearity of the electrolyte measurement result of the sample with larger target ion concentration.
In addition to the above differences, the sample analyzer 10 and other parts of the calibration method for electrolyte measurement in the sample analyzer 10 provided in this embodiment can refer to the first embodiment, and will not be described in detail herein.
The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structural changes made by the description of the present invention and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the invention.
Claims (17)
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