CN119366514A - Composition containing chlorine dioxide and method for preparing chlorine dioxide tablets - Google Patents

Abstract

The application provides a composition containing chlorine dioxide and a method for preparing a chlorine dioxide tablet, wherein the composition contains a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor, the stabilizer is one or more than two of hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride, after the composition is prepared into a tablet, the composition has good stability of a use solution after activation, can be stably stored for 6 months and has low metal corrosion, and the problems that the use solution after activation of the existing chlorine dioxide tablet is difficult to store and has strong metal corrosion are well solved.

Description

Chlorine dioxide-containing composition and method for preparing chlorine dioxide tablet

Technical Field

The application relates to the technical field of disinfection, in particular to a composition containing chlorine dioxide and a method for preparing a chlorine dioxide tablet.

Background

Chlorine dioxide was found by Sir Humphrey Davy in 1811 and the use of chlorine dioxide for pulp bleaching and potable water treatment was reported around 1940. ClO ₂, used at pH levels of 3.0 to 8.0, does not form carcinogenic by-products such as dioxins, chloroform, haloacetic acid, etc., its residue is H ₂O、NaCl、CO₂, and it does not combine with phenols to form toxic chlorophenolides. Chlorine dioxide at low concentrations is considered harmless to humans, animals and plants. And the oxidation activity of the chlorine dioxide is 2.63 times of that of the chlorine, and the effect of killing bacteria, germs, algae, zooplankton and the like is better than that of liquid chlorine. Because of the characteristics of high efficiency and low toxicity of chlorine dioxide, the chlorine dioxide is now regarded by world health organization as Al-level high-efficiency bactericide and excellent-performance bactericide, and the application fields of the chlorine dioxide relate to industries such as water treatment, papermaking, food, medical and health, cultivation and the like.

Chlorine dioxide is a gas at normal temperature. The material is unstable, has the characteristics of easy decomposition of visible light, easy occurrence of low-level explosion and the like, and brings inconvenience to storage and transportation of the material, thereby influencing the wide popularization and use of the material. Thus, methods for producing stable chlorine dioxide solutions and solid chlorine dioxide formulations have been sought.

Chlorine dioxide is unstable in aqueous solution and decays by itself, chen Bingji reports that ClO ₂ decays at room temperature, clO ₂ decays under acidic conditions with Cl ^- as the main product, a small amount of ClO ₂ ^- as the main product, and ClO ₂ ^- and a small amount of ClO ₃ ^- as the main product under neutral conditions. And the external factors influencing the stability of the chlorine dioxide, such as temperature, illumination, metal ions, pH value, microorganisms and the like, are also more. The short storage period of chlorine dioxide is the biggest factor limiting the large-scale popularization of chlorine dioxide. The appearance of the chlorine dioxide tablet solves the problem of short storage period, and the storage period of the chlorine dioxide tablet can reach more than two years. However, even if the chlorine dioxide tablet is prepared into a use solution, the storage period of the use solution is generally not longer than one month, and the stability of the tablet is ensured and the stability of the use solution after activation is less in the current research of the chlorine dioxide tablet. And chlorine dioxide has certain corrosiveness to metals such as carbon steel, copper, aluminum and the like under different concentrations, and especially has stronger corrosiveness to carbon steel. This also limits the application of chlorine dioxide to some extent, and thus reducing the corrosiveness of chlorine dioxide use fluids is also important.

Disclosure of Invention

Based on the problems, the application provides a composition containing chlorine dioxide and a method for preparing a chlorine dioxide tablet, wherein the composition containing chlorine dioxide has good stability of a using solution and low corrosiveness to metals after being prepared into a tablet and activated.

The specific technical scheme of the application is as follows:

there is provided a composition comprising chlorine dioxide, which comprises a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor, wherein the stabilizer is one or more selected from hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride.

Preferably, for the composition described above, wherein the corrosion inhibitor is selected from one or more of hydroxyethylidene bisphosphonic acid, sodium salt of methylbenzotriazole, azabenzene ring polyaminocaproic acid, tetrasodium iminodisuccinate and organosiloxane.

For the composition of any of the above claims, wherein the composition further comprises an activator, a disintegrant, a binder, and a lubricant.

The composition comprises, by mass, 30-50% of the chlorine dioxide precursor, 20-30% of the activator, 2-8% of the disintegrant, 8-15% of the binder, 0.1-1% of the stabilizer, 0.05-0.5% of the corrosion inhibitor and 0.1-0.5% of the lubricant.

The composition comprises one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid, and/or

The disintegrating agent comprises sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, and/or

The adhesive is one or more selected from polyvinylpyrrolidone K30, sodium carboxymethylcellulose, hydroxypropyl methylcellulose and polyethylene glycol, and/or

The lubricant is one or more selected from talcum powder, magnesium stearate and micro silica gel.

For the composition of any of the above claims, wherein the dosage form of the composition is a tablet.

The application provides a method for preparing a chlorine dioxide tablet, which comprises the following steps:

mixing and crushing a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture;

mixing and crushing an activating agent and a disintegrating agent to obtain a second mixture;

mixing the first mixture and the second mixture, and tabletting to obtain chlorine dioxide tablets;

And mixing and crushing the corrosion inhibitor and the chlorine dioxide precursor, the adhesive, the stabilizer and the lubricant to obtain a first mixture or mixing and crushing the corrosion inhibitor and the activator and the disintegrating agent to obtain a second mixture.

The method of the above, wherein the chlorine dioxide precursor is 30-50% by mass, the activator is 20-30% by mass, the disintegrant is 2-8% by mass, the binder is 8-15% by mass, the stabilizer is 0.1-1% by mass, the corrosion inhibitor is 0.05-0.5% by mass, and the lubricant is 0.1-0.5% by mass.

The method, wherein the activator is one or more selected from citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid, and/or

The disintegrating agent comprises sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, and/or

The adhesive is one or more selected from polyvinylpyrrolidone K30, sodium carboxymethylcellulose, hydroxypropyl methylcellulose and polyethylene glycol, and/or

The lubricant is one or more selected from pulvis Talci, magnesium stearate and silica gel micropowder, and/or

The stabilizer is one or more selected from hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride, and/or

The corrosion inhibitor is one or more than two selected from hydroxyethylidene diphosphonic acid, methyl benzotriazol sodium salt, azabenzene ring polyamino caproic acid, iminodisuccinic acid tetrasodium and organosiloxane.

ADVANTAGEOUS EFFECTS OF INVENTION

After the composition is prepared into a tablet, the stability of the use solution is good after activation, the use solution can be stably stored for 6 months, and the corrosion to metal is low, so that the problems that the use solution after activation of the existing chlorine dioxide tablet is difficult to store and has strong corrosion to metal can be well solved.

Detailed Description

The application is described in detail below in connection with the embodiments described. While specific embodiments of the application are shown, it should be understood that the application may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the application to those skilled in the art.

It should be noted that certain terms are used throughout the description and claims to refer to particular components. Those of skill in the art will understand that a person may refer to the same component by different names. The specification and claims do not identify differences in terms of components, but rather differences in terms of the functionality of the components. As referred to throughout the specification and claims, the terms "include" or "comprising" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description hereinafter sets forth a preferred embodiment for practicing the application, but is not intended to limit the scope of the application, as the description proceeds with reference to the general principles of the description. The scope of the application is defined by the appended claims.

The application provides a composition containing chlorine dioxide, which comprises a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor, wherein the stabilizer is one or more than two of hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride.

The chlorine dioxide precursor may be a material commonly used in the art, for example, sodium chlorite, potassium chlorite, calcium chlorite, magnesium chlorite, barium chlorite, etc., preferably sodium chlorite.

In some embodiments, the corrosion inhibitor is selected from one or more of hydroxyethylidene bisphosphonic acid, sodium salt of methylbenzotriazole, azabenzene ring polyaminocaproic acid, tetrasodium iminodisuccinate, and organosiloxane.

In some embodiments, the composition further comprises an activator, a disintegrant, a binder, and a lubricant.

In the present application, the activator, the disintegrant, the binder and the lubricant are activators, disintegrants, binders and lubricants commonly used in the art, which may be selected conventionally according to need without any limitation by those skilled in the art, for example, the activator may be citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid or a combination thereof;

The disintegrating agent may comprise sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, etc.;

The binder can be polyvinylpyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol and the like or a combination thereof;

The lubricant can be talcum powder, magnesium stearate, micro silica gel and the like or a combination thereof.

In some embodiments, the chlorine dioxide precursor is 30-50% by mass, the activator is 20-30% by mass, the disintegrant is 2-8% by mass, the binder is 8-15% by mass, the stabilizer is 0.1-1% by mass, the corrosion inhibitor is 0.05-0.5% by mass, and the lubricant is 0.1-0.5% by mass.

For example, the chlorine dioxide precursor may be 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, etc., by mass percent of the composition;

the activator may be 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, etc.;

The disintegrating agent is 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, etc.;

the binder may be 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.;

The stabilizer is 0.1%、0.15%、0.2%、0.25%、0.3%、0.35%、0.4%、0.45%、0.5%、0.55%、0.6%、0.65%、0.7%、0.75%、0.8%、0.85%、0.9%、0.95%、1%;

The corrosion inhibitor may be 0.05%, 006%, 0.07%, 0.08%, 0.09%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, etc.;

the lubricant may be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, etc.

In the present application, for the stabilizer, when two or more of hydroxypropyl- β -cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride are selected, any combination may be made, one component of the combination must not be lower than one tenth of the other component, as long as the content of the stabilizer is within the above-described range, for example, when a combination of hydroxypropyl- β -cyclodextrin and sodium silicate is used as the stabilizer, the mass ratio (m _{Hydroxypropyl radical -β- Cyclodextrin} :m _{Sodium silicate} ) of the two may be 10:1 to 1:10, and similarly, when a combination of sodium hexametaphosphate and boron nitride is used as the stabilizer, the mass ratio (m _{sodium hexametaphosphate} :m _{Boron nitride} ) of the two may be 10:1 to 1:10;

For example, the mass ratio of hydroxypropyl- β -cyclodextrin to sodium silicate (m _{Hydroxypropyl radical -β- Cyclodextrin} :m _{Sodium silicate} ) may be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.;

The mass ratio (m _{sodium hexametaphosphate} :m _{Boron nitride} ) of sodium hexametaphosphate to boron nitride can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

Also for the corrosion inhibitor, when two or more of hydroxyethylidene bisphosphonic acid, tolyltriazole sodium salt, azabenzene ring polyaminocaproic acid, tetrasodium iminodisuccinate and organosiloxane are selected, any combination may be made, one component in the combination must not be less than one tenth of the other component, as long as the content of the corrosion inhibitor is within the above-mentioned range.

For example, when a combination of hydroxyethylidene bisphosphonic acid and sodium salt of methylbenzotriazole is used as the corrosion inhibitor, the mass ratio (m _{hydroxy ethylidene diphosphonic acid} :m _{Sodium salt of methylbenzotriazole} ) of the two may be 10:1 to 1:10, and similarly, when a combination of azabenzene ring polyaminohexanoic acid and organosiloxane is used as the corrosion inhibitor, the mass ratio (m _{azabenzene ring polyaminocaproic acid} :m _{Organosiloxane ketone} ) of the two may be 10:1 to 1:10;

For example, the mass ratio of hydroxyethylidene bisphosphonic acid to sodium salt of methylbenzotriazole (m _{hydroxy ethylidene diphosphonic acid} :m _{Sodium salt of methylbenzotriazole} ) may be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.;

The mass ratio (m _{azabenzene ring polyaminocaproic acid} :m _{Organosiloxane ketone} ) of azabenzphetamine to organosiloxane can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

In some embodiments, the dosage form of the composition is a tablet.

The composition provided by the application has the advantages that after the composition is prepared into tablets, the stability of the use solution is good, the use solution can be stably stored for more than 6 months, the use solution can be stored for about one month after the activation in the prior art, the corrosion to metals is low, the use solution is basically non-corrosive to some metals, and the use solution is slightly corrosive to some metals.

The application provides a method for preparing a chlorine dioxide tablet, which comprises the following steps:

mixing and crushing a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture;

mixing and crushing an activating agent and a disintegrating agent to obtain a second mixture;

mixing the first mixture and the second mixture, and tabletting to obtain chlorine dioxide tablets;

And mixing and crushing the corrosion inhibitor and the chlorine dioxide precursor, the adhesive, the stabilizer and the lubricant to obtain a first mixture or mixing and crushing the corrosion inhibitor and the activator and the disintegrating agent to obtain a second mixture.

In the present application, the specific corrosion inhibitor may be mixed and pulverized with the chlorine dioxide precursor, the binder, the stabilizer and the lubricant to obtain a first mixture, or mixed and pulverized with the activator and the disintegrant to obtain a second mixture, according to the performance requirements thereof.

For example, when the corrosion inhibitor is hydroxyethylidene bisphosphonic acid and/or sodium salt of methylbenzotriazole, it may be mixed with an activator and a disintegrant and crushed to obtain a second mixture;

When the corrosion inhibitor is azabenzene ring polyamino caproic acid and/or organosiloxane, it may be mixed with chlorine dioxide precursor, adhesive, stabilizer and lubricant and crushed to obtain the first mixture.

In some embodiments, the activator, disintegrant, and optionally corrosion inhibitor are baked, preferably in an oven at 50-60 ℃, preferably for 12-24 hours, prior to comminution in preparing the second mixture.

In some embodiments, the temperature is 20-30 ℃ and/or the relative humidity is 20-40% during the process of preparing chlorine dioxide tablets.

For example, the temperature may be 20 ℃, 21 ℃, 22 ℃, 23 ℃, 24 ℃, 25 ℃, 26 ℃, 27 ℃, 28 ℃, 29 ℃,30 ℃, etc.;

the relative humidity may be 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, 40%, etc.

In some embodiments, the chlorine dioxide precursor is 30-50% by mass, the activator is 20-30% by mass, the disintegrant is 2-8% by mass, the binder is 8-15% by mass, the stabilizer is 0.1-1% by mass, the corrosion inhibitor is 0.05-0.5% by mass, and the lubricant is 0.1-0.5% by mass. In some embodiments, the activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride, and phytic acid, and/or

The disintegrating agent comprises sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, and/or

The adhesive is one or more selected from polyvinylpyrrolidone K30, sodium carboxymethylcellulose, hydroxypropyl methylcellulose and polyethylene glycol, and/or

The lubricant is one or more selected from pulvis Talci, magnesium stearate and silica gel micropowder, and/or

The stabilizer is one or more selected from hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride, and/or

The corrosion inhibitor is one or more than two selected from hydroxyethylidene diphosphonic acid, methyl benzotriazol sodium salt, azabenzene ring polyamino caproic acid, iminodisuccinic acid tetrasodium and organosiloxane.

The chlorine dioxide tablet prepared by the method is very stable in use solution after activation, can be stably stored for 6 months, and has small corrosion to metals.

Examples

The materials used in the test and the test methods are described generally and/or specifically in the examples which follow,% represents wt%, i.e. weight percent, unless otherwise specified. The reagents or apparatus used were conventional reagent products commercially available without the manufacturer's knowledge.

Example 1

(1) Adding chlorine dioxide precursor, adhesive, stabilizer and lubricant into pulverizer, pulverizing, and sieving the powder with 100 mesh sieve to obtain first mixture.

Wherein the chlorine dioxide precursor is sodium chlorite and the dosage is 500g.

Wherein the adhesive is polyvinylpyrrolidone K30, and the dosage is 80g.

Wherein the stabilizer is a mixture of hydroxypropyl-beta-cyclodextrin and sodium silicate, the dosage of the hydroxypropyl-beta-cyclodextrin is 1g, and the dosage of the sodium silicate is 5g.

Wherein the lubricant is talcum powder and the dosage is 5g.

(2) And (3) putting the activator, the disintegrating agent and the corrosion inhibitor into a 50 ℃ oven for baking for 24 hours, cooling, taking out, crushing by a crusher, and sieving the powder by a 100-mesh sieve to obtain a second mixture.

Wherein the activator is tartaric acid, and the dosage is 300g.

Wherein the disintegrating agent is a mixture of citric acid and sodium bicarbonate, the dosage of the citric acid is 30g, and the dosage of the sodium bicarbonate is 100g.

Wherein the corrosion inhibitor is a mixture of hydroxyethylidene diphosphonic acid and sodium salt of methyl benzotriazol, the dosage of the hydroxyethylidene diphosphonic acid is 1g, and the dosage of the sodium salt of methyl benzotriazol is 1.5g.

(3) And uniformly mixing the first mixture and the second mixture, and directly tabletting to obtain the chlorine dioxide tablet.

The whole preparation process is carried out under the conditions that the temperature is 20-30 ℃ and the relative humidity is 20-40%.

Example 2

(1) Adding chlorine dioxide precursor, corrosion inhibitor, adhesive, stabilizer and lubricant into a pulverizer, pulverizing, and sieving the powder with 100 mesh sieve to obtain a first mixture.

Wherein the chlorine dioxide precursor is sodium chlorite and the dosage is 300g.

Wherein the corrosion inhibitor is a mixture of azabenzene ring polyamino caproic acid and organic siloxane ketone, the dosage of the azabenzene ring polyamino caproic acid is 3g, and the dosage of the organic siloxane ketone is 2g.

Wherein the adhesive is a mixture of hydroxypropyl methylcellulose and polyethylene glycol, the dosage of the hydroxypropyl methylcellulose is 50g, and the dosage of the polyethylene glycol is 100g.

Wherein the stabilizer is a mixture of sodium hexametaphosphate and boron nitride, the dosage of the sodium hexametaphosphate is 10g, and the dosage of the boron nitride is 1g.

Wherein the lubricant is micro silica gel powder with the dosage of 3g.

(2) The activator and the disintegrating agent are put into a 60 ℃ oven to be baked for 12 hours, then are taken out to be crushed by a crusher, and the powder is sieved by a 100-mesh sieve, thus obtaining a second mixture.

Wherein the activator is a mixture of potassium dihydrogen phosphate and aluminum trichloride, the dosage of the potassium dihydrogen phosphate is 150g, and the dosage of the aluminum trichloride is 150g.

Wherein the disintegrating agent is a mixture of malic acid and sodium bicarbonate, the dosage of the malic acid is 50g, and the dosage of the sodium bicarbonate is 100g.

(3) And uniformly mixing the first mixture and the second mixture, and directly tabletting to obtain the chlorine dioxide tablet.

The whole preparation process is carried out under the conditions that the temperature is 20-30 ℃ and the relative humidity is 20-40%.

Example 3

Example 3 differs from example 1 in that only hydroxypropyl-beta-cyclodextrin was used in an amount of 6g to prepare chlorine dioxide tablets.

Example 4

Example 4 differs from example 3 in that the chlorine dioxide tablet is prepared using an amount of hydroxypropyl-beta-cyclodextrin of 1g.

Example 5

Example 5 differs from example 3 in that the chlorine dioxide tablet is prepared using an amount of hydroxypropyl-beta-cyclodextrin of 10 g.

Example 6

Example 6 differs from example 3 in that the chlorine dioxide tablet is prepared using an amount of hydroxypropyl-beta-cyclodextrin of 4 g.

Example 7

Example 6 differs from example 3 in that the chlorine dioxide tablet is prepared using an amount of hydroxypropyl-beta-cyclodextrin of 15 g.

Example 8

Example 8 differs from example 1 in that only sodium silicate was used, the amount of sodium silicate being 6g, to prepare chlorine dioxide tablets.

Example 9

Example 9 differs from example 3 in that 6g of magnesium sulfate, a stabilizer conventional in the art, was used to prepare chlorine dioxide tablets.

Example 10

Example 10 differs from example 1 in that only the sodium salt of methylbenzotriazole was used to prepare chlorine dioxide tablets.

Example 11

Example 11 differs from example 10 in that a chlorine dioxide tablet was prepared with an amount of 1g of sodium salt of methylbenzotriazole.

Example 12

Example 12 differs from example 10 in that a chlorine dioxide tablet is prepared with 5g of sodium salt of methylbenzotriazole.

Example 13

Example 13 differs from example 10 in that the chlorine dioxide tablet is prepared using 2.5g of sodium phosphate, a corrosion inhibitor conventional in the art.

Example 14

Example 14 differs from example 1 in that only hydroxyethylidene bisphosphonic acid was used in an amount of 2.5g to prepare chlorine dioxide tablets.

Example 15

Example 15 differs from example 2 in that only sodium hexametaphosphate was used in an amount of 11g to prepare chlorine dioxide tablets.

Example 16

Example 16 differs from example 2 in that only boron nitride was used, the amount of boron nitride being 11g, to prepare chlorine dioxide tablets.

Example 17

Example 17 differs from example 2 in that only azabenzene ring polyamino caproic acid was used, the amount of azabenzene ring polyamino caproic acid used being 5g to prepare chlorine dioxide tablets.

Example 18

Example 18 differs from example 2 in that only organosiloxane ketone was used in an amount of 5g to prepare chlorine dioxide tablets.

Example 19

Example 19 differs from example 1 in that a chlorine dioxide tablet is prepared using hydroxypropyl-beta-cyclodextrin in an amount of 0.1g and sodium silicate in an amount of 5g.

Example 20

Example 20 differs from example 1 in that a chlorine dioxide tablet is prepared using hydroxypropyl-beta-cyclodextrin in an amount of 5g and sodium silicate in an amount of 1 g.

Example 21

Example 21 differs from example 1 in that a chlorine dioxide tablet was prepared using a quantity of hydroxyethylidene diphosphonic acid of 0.1g and a quantity of sodium methylbenzotriazole salt of 1.5 g.

Example 22

Example 22 differs from example 1 in that chlorine dioxide tablets were prepared using 1.5g of hydroxyethylidene diphosphonic acid and 1g of sodium salt of methylbenzotriazole.

Example 23

Example 23 differs from example 2 in that chlorine dioxide tablets were prepared using sodium hexametaphosphate in an amount of 1g and boron nitride in an amount of 10 g.

Example 24

Example 24 differs from example 2 in that chlorine dioxide tablets were prepared using 2g of azabenzene ring polyaminocaproic acid and 3g of organosiloxane.

Comparative example 1

(1) The chlorine dioxide precursor, the adhesive and the lubricant are added into a pulverizer to be pulverized, and the powder is sieved by a 100-mesh sieve to obtain a first mixture.

Wherein the chlorine dioxide precursor is sodium chlorite and the dosage is 500g.

Wherein the adhesive is polyvinylpyrrolidone K30, and the dosage is 80g.

Wherein the lubricant is talcum powder and the dosage is 5g.

(2) And (3) putting the activator and the disintegrating agent into a 50 ℃ oven for baking for 24 hours, cooling, taking out, crushing by a crusher, and sieving the powder by a 100-mesh sieve to obtain a second mixture.

Wherein the activator is tartaric acid, and the dosage is 300g.

Wherein the disintegrating agent is a mixture of citric acid and sodium bicarbonate, the dosage of the citric acid is 30g, and the dosage of the sodium bicarbonate is 100g.

(3) And uniformly mixing the first mixture and the second mixture, and directly tabletting to obtain the chlorine dioxide tablet.

The whole preparation process is carried out under the conditions that the temperature is 20-30 ℃ and the relative humidity is 20-40%.

Comparative example 2

(1) The chlorine dioxide precursor, the adhesive and the lubricant are added into a pulverizer to be pulverized, and the powder is sieved by a 100-mesh sieve to obtain a first mixture.

Wherein the chlorine dioxide precursor is sodium chlorite and the dosage is 300g.

Wherein the adhesive is a mixture of hydroxypropyl methylcellulose and polyethylene glycol, the dosage of the hydroxypropyl methylcellulose is 50g, and the dosage of the polyethylene glycol is 100g.

Wherein the lubricant is micro silica gel powder with the dosage of 3g.

(2) The activator and the disintegrating agent are put into a 60 ℃ oven to be baked for 12 hours, then are taken out to be crushed by a crusher, and the powder is sieved by a 100-mesh sieve, thus obtaining a second mixture.

Wherein the activator is a mixture of potassium dihydrogen phosphate and aluminum trichloride, the dosage of the potassium dihydrogen phosphate is 150g, and the dosage of the aluminum trichloride is 150g.

Wherein the disintegrating agent is a mixture of malic acid and sodium bicarbonate, the dosage of the malic acid is 50g, and the dosage of the sodium bicarbonate is 100g.

(3) And uniformly mixing the first mixture and the second mixture, and directly tabletting to obtain the chlorine dioxide tablet.

The whole preparation process is carried out under the conditions that the temperature is 20-30 ℃ and the relative humidity is 20-40%.

TABLE 1

;

。

Experimental example stability and metal corrosiveness test

1G of the chlorine dioxide tablets in examples 1-12 and comparative examples 1-2 was dissolved in 1L of purified water, and after activation, 50-200mg/L of chlorine dioxide use solution was obtained, and stability and metal corrosiveness of the use solution were measured by referring to methods in "sterilizing technical Specification" (2002 edition) 2.2.3 and 2.2.4, and the results are shown in Table 2.

TABLE 2

。

In summary, the composition of the application adds the stabilizer and the corrosion inhibitor, wherein the stabilizer and the corrosion inhibitor are specific stabilizers and corrosion inhibitors, and the prepared tablet has greatly improved stability of the use solution and greatly reduced corrosion to metals after activation, which is beneficial to large-scale popularization and application of chlorine dioxide.

The above description is only a preferred embodiment of the present application, and is not intended to limit the application in any way, and any person skilled in the art may make modifications or alterations to the disclosed technical content to the equivalent embodiments. However, any simple modification, equivalent variation and variation of the above embodiments according to the technical substance of the present application still fall within the protection scope of the technical solution of the present application.

Claims (9)

1. A composition comprising chlorine dioxide comprising a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor;

The stabilizer is one or more selected from hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride.

2. The composition of claim 1, wherein the corrosion inhibitor is selected from one or more of hydroxyethylidene bisphosphonic acid, sodium salt of methylbenzotriazole, azabenzene ring polyaminocaproic acid, tetrasodium iminodisuccinate, and organosiloxane.

3. The composition of any of claims 1-2, wherein the composition further comprises an activator, a disintegrant, a binder, and a lubricant.

4. A composition according to claim 3, wherein the chlorine dioxide precursor is 30-50% by mass of the composition, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%.

5. A composition according to claim 3, wherein the activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid, and/or

The disintegrating agent comprises sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, and/or

The adhesive is one or more selected from polyvinylpyrrolidone K30, sodium carboxymethylcellulose, hydroxypropyl methylcellulose and polyethylene glycol, and/or

The lubricant is one or more selected from talcum powder, magnesium stearate and micro silica gel.

6. The composition of any one of claims 1-2, wherein the composition is in the form of a tablet.

7. A method of preparing a chlorine dioxide tablet comprising:

mixing and crushing a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture;

mixing and crushing an activating agent and a disintegrating agent to obtain a second mixture;

mixing the first mixture and the second mixture, and tabletting to obtain chlorine dioxide tablets;

And mixing and crushing the corrosion inhibitor and the chlorine dioxide precursor, the adhesive, the stabilizer and the lubricant to obtain a first mixture or mixing and crushing the corrosion inhibitor and the activator and the disintegrating agent to obtain a second mixture.

8. The method of claim 7, wherein the chlorine dioxide precursor is 30-50% by mass, the activator is 20-30% by mass, the disintegrant is 2-8% by mass, the binder is 8-15% by mass, the stabilizer is 0.1-1% by mass, the corrosion inhibitor is 0.05-0.5% by mass, and the lubricant is 0.1-0.5% by mass.

9. The method according to claim 7 or 8, wherein the activator is one or more selected from citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid, and/or

The disintegrating agent comprises sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, and/or

The adhesive is one or more selected from polyvinylpyrrolidone K30, sodium carboxymethylcellulose, hydroxypropyl methylcellulose and polyethylene glycol, and/or

The lubricant is one or more selected from pulvis Talci, magnesium stearate and silica gel micropowder, and/or

The stabilizer is one or more selected from hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride, and/or

The corrosion inhibitor is one or more than two selected from hydroxyethylidene diphosphonic acid, methyl benzotriazol sodium salt, azabenzene ring polyamino caproic acid, iminodisuccinic acid tetrasodium and organosiloxane.