CN118356297B - Multi-wavelength medical laser systems - Google Patents
Multi-wavelength medical laser systems Download PDFInfo
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- CN118356297B CN118356297B CN202410625035.8A CN202410625035A CN118356297B CN 118356297 B CN118356297 B CN 118356297B CN 202410625035 A CN202410625035 A CN 202410625035A CN 118356297 B CN118356297 B CN 118356297B
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- 238000011282 treatment Methods 0.000 claims abstract description 33
- 230000005540 biological transmission Effects 0.000 claims abstract description 31
- 210000004087 cornea Anatomy 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 18
- 230000008569 process Effects 0.000 claims abstract description 16
- 210000005252 bulbus oculi Anatomy 0.000 claims description 19
- 239000007787 solid Substances 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 4
- 238000012546 transfer Methods 0.000 abstract description 3
- 210000001508 eye Anatomy 0.000 description 11
- 230000003287 optical effect Effects 0.000 description 11
- 239000010410 layer Substances 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000004075 alteration Effects 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 208000014733 refractive error Diseases 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- ISQINHMJILFLAQ-UHFFFAOYSA-N argon hydrofluoride Chemical compound F.[Ar] ISQINHMJILFLAQ-UHFFFAOYSA-N 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002430 laser surgery Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012014 optical coherence tomography Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00804—Refractive treatments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00814—Laser features or special beam parameters therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Laser Surgery Devices (AREA)
Abstract
本发明提供了一种多波长医疗激光系统，涉及激光设备技术领域。本发明所述系统包括：包括飞秒激光器、大数字孔径聚焦镜片组、深紫外脉冲激光器、光束补偿器、第一激光传输装置、第一反射镜、第二激光传输装置、定位激光装置眼球追踪系统、手术显微镜，深紫外纳米激光器产生波长为190～213纳米的深紫外激光，飞秒激光器产生波长在800～1100纳米之间的飞秒激光，可以由第一反射镜对飞秒激光(例如1053纳米激光)进行反射，对深紫外激光(例如：213纳米激光)进行透射，或，由第一反射镜对深紫外激光进行反射，对飞秒激光进行透射，从而由一台仪器实现既可以利用深紫外激光对角膜进行精准切削处理，又可以利用飞秒激光在眼角膜中间层进行切削，在治疗过程中无需使用多台仪器，不需要对患者进行转移，简化治疗过程，提高治疗效率。
The present invention provides a multi-wavelength medical laser system, which relates to the technical field of laser equipment. The system of the present invention includes: a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet pulse laser, a beam compensator, a first laser transmission device, a first reflector, a second laser transmission device, a positioning laser device eye tracking system, and a surgical microscope. The deep ultraviolet nano-laser generates a deep ultraviolet laser with a wavelength of 190 to 213 nanometers, and the femtosecond laser generates a femtosecond laser with a wavelength between 800 and 1100 nanometers. The first reflector can reflect the femtosecond laser (for example, a 1053 nanometer laser) and transmit the deep ultraviolet laser (for example, a 213 nanometer laser), or the first reflector can reflect the deep ultraviolet laser and transmit the femtosecond laser, so that one instrument can realize both precise corneal cutting with a deep ultraviolet laser and cutting in the middle layer of the cornea with a femtosecond laser. During the treatment process, there is no need to use multiple instruments, and there is no need to transfer the patient, which simplifies the treatment process and improves the treatment efficiency.
Description
Technical Field
The embodiment of the invention relates to the technical field of laser equipment, in particular to a multi-wavelength medical laser system.
Background
In the prior art, the treatment or diagnosis of the eye is generally carried out using individual instruments whose design is adapted to the respective application purpose. For example, if refractive errors are to be corrected by laser surgery on the cornea of an eye, first an instrument suitable for diagnosing the eye is used, such as using a slit lamp, an optical arrangement for three-dimensional measurement of the cornea, an arrangement for optical coherence tomography, etc. The results achieved with such diagnostic instruments are then used to determine the measure of treatment, and the instrument that is available for treatment is selected and prepared. In the treatment, a flap-like cover (Deckel), called a "flap", is first formed on the corneal surface by means of a so-called "flap knife (FLAPSCHNEIDE)" laser (also known as a laser keratome, or microkeratome in its mechanical variant), the thickness of which is significantly smaller than the thickness of the cornea, before the surgery to correct refractive errors. In order to be able to produce such flap caps as precisely as possible, laser keratomes have been used in the prior art which produce a therapeutic laser beam with a pulse width of less than 10 -12 s. Thus, a locally limited breakdown (Durchbruch) with an extension of only a few micrometers is achieved in the cornea. By purposefully arranging a plurality of such breakdowns together, the desired "skin flap" can be constructed and rendered reversible. After the "flap" is created, tissue is resected from the exposed interior region of the cornea in the inverted "flap" using another instrument for the purpose of correcting refractive errors. The ablation operation in turn needs to be performed by introducing energy by means of a pulsed therapeutic laser beam, which may be from an excimer laser. Diagnostic instrumentation is also often required after treatment in order to be able to evaluate the treatment outcome and to be able to schedule subsequent treatments if necessary.
It follows that the order of the instruments used for diagnosing or treating the eye must be carefully considered during the treatment, wherein in particular the identification data, diagnosis data and/or treatment data relating to the patient and the configuration data or protocol data and control signals relating to the treatment are taken into account, so that the doctor or user who is taking the treatment can make the necessary adjustments for the treatment or diagnosis on the respectively used instruments. The patient also needs to be repositioned from instrument to instrument or the individual instruments need to be moved to align the patient's eyes for diagnosis or treatment.
In the prior art, since the instruments used are typically separate from each other, it is necessary to transport the patient from one instrument to the next during the treatment. However, this alone does not guarantee the exact positioning necessary for the treatment or diagnosis on the respective instrument. Since the geometry of the instruments is not consistent with each other, it is not only necessary to transport the patient between the instruments, but also to adjust the position of the patient according to the corresponding instrument design.
Disclosure of Invention
Embodiments of the present invention provide a multi-wavelength medical laser system to at least partially solve the problems existing in the related art.
The embodiment of the invention provides a multi-wavelength medical laser system, which comprises a femtosecond laser, a large-numerical-aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first reflecting mirror, a second laser transmission device, a positioning laser device eyeball tracking system and a surgical microscope, wherein the deep ultraviolet nanometer laser generates laser with the wavelength of 190-213 nanometers, the femtosecond laser generates laser with the wavelength of 800-1100 nanometers, the laser with the wavelength of 190-213 nanometers is transmitted to the first reflecting mirror through the first laser transmission device, the laser with the wavelength of 800-1100 nanometers is transmitted to the first reflecting mirror through the large-numerical-aperture focusing lens group, the laser passing through the first reflecting mirror is transmitted to a target position through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the eyeball tracking system and the surgical microscope, the laser with the wavelength of 190-213 nanometers is used for cutting the cornea, and an interlayer between 800-1100 nanometers is used for cutting the cornea.
Optionally, the deep ultraviolet nano laser generates laser light with a wavelength of 213 nm, the femto-second laser generates laser light with a wavelength of 1053 nm, the first mirror reflects 1053 nm laser light in a first state and transmits 213 nm laser light, and the first mirror reflects 213 nm laser light and transmits 1053 nm laser light in a second state.
Optionally, the femtosecond laser is a high repetition rate femtosecond laser between 800 nanometers and 1100 nanometers.
Optionally, the deep ultraviolet laser is a Nd-YAG quintupled 213 nanometer pulse laser, and the solid laser is subjected to frequency conversion to generate the deep ultraviolet pulse laser with the wavelength between 190 nanometers and 213 nanometers.
Optionally, the first laser transmission device comprises a beam compensator, a reflector, a beam expander and a beam homogenizer.
Optionally, the second laser transmission device comprises an X-Y scanning mirror and a focusing lens.
Optionally, the femtosecond laser is an optical fiber laser, the pulse energy is 1 mu J, the pulse width is 300fs, the pulse frequency is less than 4MHz, and the cooling mode is air cooling.
Optionally, the spot diameter of the laser generated by the fiber laser is 3 μm, the focusing energy is 150 nJ/pulse, and the focusing range is 300 μm.
According to the multi-wavelength medical laser system provided by the embodiment of the invention, the first reflecting mirror is used for reflecting 1053 nanometer laser and transmitting 213 nanometer laser, or the first reflecting mirror is used for reflecting 213 nanometer laser and transmitting 1053 nanometer laser, so that the precise cutting treatment of cornea by 213 nanometer laser and cutting of the intermediate layer of cornea by 1053 nanometer laser can be realized by one instrument, a plurality of instruments are not needed in the treatment process, the patient is not needed to be transferred, the treatment process can be simplified, and the treatment efficiency is improved.
In the embodiment of the invention, the solid laser is used for replacing 193 nm argon fluoride excimer gas laser widely used at present by using deep ultraviolet pulse solid laser with the wavelength of 190 nm-213 nm generated by various frequency conversion technologies, so that a toxic high-pressure fluorine gas cylinder can be avoided, the environmental threat possibly caused by gas leakage of the high-pressure gas cylinder is effectively avoided, and the safety of equipment to doctors and patients is greatly improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments of the present invention will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 shows a schematic structural diagram of a multi-wavelength medical laser system according to an embodiment of the present invention.
Detailed Description
In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.
In the embodiment of the invention, a multi-wavelength medical laser system is provided, as shown in fig. 1, wherein the multi-wavelength medical laser system provided by the embodiment of the invention comprises a femtosecond laser, a large-numerical-aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first reflecting mirror, a second laser transmission device, a positioning laser device eyeball tracking system and a surgical microscope, the deep ultraviolet nanometer laser generates laser with the wavelength of 190-213 nanometers, the femtosecond laser generates laser with the wavelength of 800-1100 nanometers, the laser with the wavelength of 190-213 nanometers is transmitted to the first reflecting mirror through the first laser transmission device, the laser with the wavelength of 800-1100 nanometers is transmitted to a first reflecting mirror through the large-numerical-aperture focusing lens group, the laser with the laser beam compensator is transmitted to a target position through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the eyeball tracking system and the surgical microscope, the laser with the wavelength of 190-213 nanometers is used for cutting an intermediate layer between the laser with the wavelength of 800-213 nanometers, and the laser with the angle of 1100 nanometers is cut.
In the embodiment of the invention, the femtosecond laser can be specifically a high repetition frequency femtosecond laser between 800 nanometers and 1100 nanometers.
In the embodiment of the invention, the deep ultraviolet laser is a 213 nanometer pulse laser with Nd: YAG frequency doubling, and can generate the deep ultraviolet pulse laser with the wavelength of 190-213 nanometers by using a solid laser through a frequency conversion technology.
In the practical application process, one of the 213 nanometer laser or the deep ultraviolet nanometer laser is selected at will.
In the practical application process, the first reflecting mirror has two states, wherein the first state can transmit 213 nanometers of laser to the second laser transmission device, and the second state can transmit 1053 nanometers of femtosecond laser to the second laser transmission device.
Alternatively, the first state of the first mirror may reflect 1053 nm laser light and transmit 213 nm laser light, and the second state of the first mirror may reflect 213 nm and transmit 1053 nm.
In this case, in the practical application process, the first mirror may be set to the second state by default, and even if one or more of the two lasers are started, the laser will not reach the eyeball position, so that misoperation may be avoided. In the operation process of the system, the femtosecond laser can be started first, the first reflecting mirror is set to be in a second state, 1053 nanometer femtosecond laser generated by the femtosecond laser reaches the eyeball position through reflection of the first reflecting mirror to finish cutting at the middle layer of the cornea, and then the deep ultraviolet nanometer laser is started, so that 213 nanometer laser generated by the deep ultraviolet nanometer laser reaches the eyeball position through transmission of the first reflecting mirror to cut the cornea.
Alternatively, the first state of the first mirror may be transmissive to 213 nm laser light and the second state may be reflective to 1053 nm laser light.
In this case, in the practical application process, the femtosecond laser may be started first, and the first mirror is adjusted to have a reflection function, so that the laser beam generated by the femtosecond laser is reflected into the second laser transmission device by the first mirror and finally transmitted to the eyeball, and cutting is performed on the middle layer of the cornea of the eyeball, and then the femtosecond laser is turned off. Starting 213 nanometer laser or deep ultraviolet nanometer laser, adjusting the first reflector to a transmission function, transmitting laser beams into the second laser transmission device through the first reflector, finally transmitting the laser beams to eyeballs, and cutting the cornea.
Specifically, the first reflecting mirror may be a lens with two sides having different curvatures, so that one side reflects the received light beam, and the other side transmits the received light beam, and in practical application, the first reflecting mirror may be turned over and angle adjusted to implement the conversion between the two states.
Specifically, the first reflecting mirror can also form a lens system by using a plurality of lenses, and the conversion of the two states is realized by adjusting parameters such as the number, the position, the curvature and the like of the lenses.
In embodiments of the present invention, the large numerical aperture focusing lens group functions to focus the beam onto a very small spot or area. Such lens groups are typically composed of a plurality of lenses to achieve more complex optical functions.
Specifically, the roles of a large numerical aperture focusing lens group include:
High numerical aperture-large numerical aperture means that the diameter and focal length of the lens are relatively large, which means that a larger range of incident light can be received. This design allows the focusing lens group to collect more light and to handle larger angles of incidence, improving the collection efficiency of the light and the luminous flux of the lens system.
High resolution the large numerical aperture focusing lens group can provide higher resolution, i.e. can focus light more clearly, resulting in a smaller size of the focal point. This is important for applications requiring high precision imaging or high resolution, such as microscopy, laser writing, optical sensors, etc.
Optical correction the focusing lens group can correct optical distortion by combining lenses of different curvatures and shapes. This includes spherical aberration, chromatic aberration, and the like. By optimizing the design and combination of the lens groups, better optical performance can be achieved, and imaging quality and definition of the focusing point can be improved.
Beam shape adjustment the large numerical aperture focusing lens group can also adjust the shape of the beam by the shape and combination of lenses. For example, by using an aspherical lens or a non-uniform lens curvature, adjustment of the beam shape, such as converting a circular beam into an elliptical beam, can be achieved.
In the embodiment of the invention, the second laser transmission device comprises an X-Y scanning mirror and a focusing lens.
In the embodiment of the invention, the femtosecond laser is an optical fiber laser, the pulse energy is 1 mu J, the pulse width is 300fs, the pulse frequency is less than 4MHz, and the cooling mode is air cooling.
In the embodiment of the invention, the diameter of a light spot of laser generated by the fiber laser is 3 mu m, the focusing energy is 150 nJ/pulse, and the focusing range is 300 mu m.
In embodiments of the present invention, the X-Y scanning mirror is a component commonly used in optical systems and laser technology. The laser beam positioning and orientation device consists of two mirrors which are perpendicular to each other, one is used for the horizontal direction (X axis) and the other is used for the vertical direction (Y axis), and by controlling the movement of the two mirrors, the accurate positioning and orientation of the laser beam can be realized. The primary function of the X-Y scanning mirror is to change the direction and position of the beam. By controlling the angle and speed of the scanning mirror, the beam can be scanned, focused, deflected and positioned on a plane.
The focusing lens in the multi-wavelength medical laser system provided by the embodiment of the invention can focus the light beam to a smaller point or area, and the focusing lens can change the propagation direction of the light beam and the intensity distribution of the light beam, so that the light beam becomes more concentrated and powerful.
Specifically, the focusing lens mainly has the following functions:
Focusing the focusing lens focuses the parallel incident beam to a focal point. The focal length of the beam and the position of the focal point can be controlled by changing the relative position of the lens to the beam or adjusting the curvature of the lens.
Beam shape adjustment-the focusing lens may change the shape of the laser beam, e.g. to convert a circular beam into an elliptical beam.
Beam adjustment-the focusing lens can adjust the diameter and divergence angle of the beam. By varying the aperture and curvature of the lens, the degree of divergence or focusing of the beam can be controlled.
Optical correction-the focusing lens may also be used to correct optical distortions in the light beam. For example, spherical lenses can correct spherical aberration, thereby maintaining better quality and sharpness of the focal point of the beam during focusing.
Specifically, in the practical application process, the direction, the position, the diameter, the divergence angle and the like of the laser beam reflected by the first reflecting mirror can be adjusted based on the matching of the large-numerical aperture focusing lens group, the X-Y scanning mirror and the focusing lens.
In the embodiment of the invention, the first laser transmission device comprises a beam compensator, a reflector, a beam expander and a beam homogenizer.
In an embodiment of the invention, the beam compensator is a device for adjusting the focal point position of the laser beam inside the eye. The device has the effects of correcting errors generated when light beams are refracted in eyeballs due to factors such as cornea morphology, diopter and the like, ensuring that laser can be accurately focused on the eyeballs, and further realizing accurate and effective treatment effects. The technique can greatly reduce the risk of operation and improve the success rate of operation and the treatment experience of patients.
In the embodiment of the invention, the beam expander can adjust and limit the diameter and the shape of the 213 nanometer laser beam. The beam expander plays a role in focusing and controlling the laser beam so that the laser beam can be accurately irradiated to a specific part of the eyes of the patient, thereby realizing an accurate treatment effect.
In the embodiment of the invention, the beam expander can ensure the focusing degree and accuracy of the laser beam, improve the safety and accuracy of the operation, limit the diameter of the laser beam within a smaller range, ensure that the laser beam can be accurately concentrated in a specific area of the eye, and simultaneously can also furthest protect surrounding tissues from unnecessary injury. By reasonably adjusting and using the beam expander, a doctor can better control the intensity and the focusing range of the laser, thereby effectively performing various ophthalmic surgical treatments.
In the embodiment of the invention, the beam expander can also help control the energy density of the laser, so as to ensure that the laser generates proper thermal effect in eye tissues to achieve the expected treatment effect.
In the embodiment of the invention, the beam expander is generally composed of a high-quality optical element, so that the quality and stability of the laser beam can be maintained.
In the embodiment of the invention, the beam homogenizer can adjust the intensity distribution of the laser beam so that the laser beam can uniformly cover the whole target area when the eye tissue of a patient is treated. Thus, the patient can be ensured to receive uniform laser energy, and the accuracy and safety of the operation are improved. Beam homogenizers are typically manufactured using special optical designs and materials to ensure that the laser beam is effectively homogenized as it passes through the device. In addition, the beam homogenizer can also help to adjust the diameter and shape of the laser beam to meet different surgical needs.
In the embodiment of the invention, in the application process of the multi-wavelength medical laser system, a doctor can complete the adjustment of the shape, the position, the focal power and the intensity of the laser beam based on the cooperation of the eyeball tracking system and the mutual cooperation of the beam compensator, the beam expander and the beam homogenizer under the observation of a surgical microscope so as to adapt to the needs of patients.
In the embodiment of the invention, 213 nanometer laser or deep ultraviolet laser generated by a 213 nanometer laser or deep ultraviolet nanometer laser can be adjusted based on the mutual coordination of a beam compensator, a beam expander and a beam homogenizer to obtain laser beams which are suitable for the actual condition of a patient, and the laser beams are transmitted out through a first reflector and then transmitted to the cornea of an eyeball through an X-Y scanning mirror and a focusing lens, so that cornea cutting is completed.
In the embodiment of the invention, in the transmission process of the 213 nanometer laser beam, the related parameters of the X-Y scanning mirror and the focusing lens in the second laser transmission device can be fixed, and the related parameters of the beam compensator, the reflector, the beam expander and the beam homogenizer in the first laser transmission device are adjusted so as to enable the shape, the position, the focusing power and the intensity of the 213 nanometer laser beam to meet the actual requirements.
The multi-wavelength medical laser system provided by the embodiment of the invention can reflect laser generated by the femtosecond laser by the first reflector, can transmit laser generated by the 213 nanometer or deep ultraviolet nanometer laser, can cut cornea by using 213 nanometer laser and can cut cornea intermediate layer by using femtosecond solid laser by one instrument, does not need to use a plurality of instruments in treatment process, does not need to transfer patients, can simplify treatment process and improve treatment efficiency.
The embodiment of the invention also provides a control method of the multi-wavelength medical laser system, which comprises the following steps:
And 1, starting a femtosecond laser, and adjusting related parameters of an X-Y scanning mirror and a focusing lens in the large-numerical aperture focusing lens group and the second laser transmission device.
And 2, controlling the adjusted femtosecond laser to emit laser, and cutting the interlayer of the cornea of the eye.
And 3, turning off the femtosecond laser, starting a 213 nanometer laser or a deep ultraviolet nanometer laser, and adjusting relevant parameters of a beam compensator, a reflector, a beam expander and a beam homogenizer in the first laser transmission device.
And 4, controlling the adjusted 213 nanometer laser or the deep ultraviolet nanometer laser to emit laser, and cutting the cornea.
The multi-wavelength medical laser system provided by the embodiment of the invention can reflect laser generated by the femtosecond laser by the first reflector, can transmit laser generated by the 213 nanometer or deep ultraviolet nanometer laser, can cut cornea by using 213 nanometer laser and can cut cornea intermediate layer by using femtosecond solid laser by one instrument, does not need to use a plurality of instruments in treatment process, does not need to transfer patients, can simplify treatment process and improve treatment efficiency.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
The previous description of the inventive aspects is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these aspects will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other aspects without departing from the scope of the invention. Thus, the present invention is not intended to be limited to the aspects shown herein but is to be accorded the widest scope consistent with the principles and novel features herein.
The foregoing description has been presented for purposes of illustration and description. Furthermore, this description is not intended to limit embodiments of the invention to the form disclosed herein. Although a number of example aspects and embodiments have been discussed above, a person of ordinary skill in the art will recognize certain variations, modifications, alterations, additions, and subcombinations thereof.
Claims (7)
1. The multi-wavelength medical laser system is characterized by comprising a femto-second laser, a large digital aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first reflecting mirror, a second laser transmission device, a positioning laser device eyeball tracking system and a surgical microscope, wherein the deep ultraviolet nanometer laser generates laser with the wavelength of 190-213 nanometers, the femto-second laser generates laser with the wavelength of 800-1100 nanometers, the laser with the wavelength of 190-213 nanometers is transmitted to the first reflecting mirror through the first laser transmission device, the laser with the wavelength of 800-1100 nanometers is transmitted to the first reflecting mirror through the large digital aperture focusing lens group, the laser with the wavelength of 800-1100 nanometers is transmitted to a target position through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the eyeball tracking system and the surgical microscope, the laser with the wavelength of 190-213 nanometers is used for cutting cornea, and the laser with the wavelength of 800-1100 nanometers is used for separating cornea intermediate layers;
The deep ultraviolet nano laser generates laser with the wavelength of 213 nanometers, the femto-second laser generates laser with the wavelength of 1053 nanometers, the first reflecting mirror reflects the 1053 nanometer laser in a first state and transmits the 213 nanometer laser, and the first reflecting mirror reflects the 213 nanometer laser in a second state and transmits the 1053 nanometer laser;
In the application process of the multi-wavelength medical laser system, a first reflecting mirror is set to be in a second state, at the moment, even if one or more of two lasers are started, laser does not reach the eyeball position, misoperation is avoided, a femtosecond laser is started first, the first reflecting mirror is adjusted to be a reflecting function, laser beams generated by the femtosecond laser are reflected into a second laser transmission device and finally transmitted to the eyeball, cutting is conducted on an intermediate layer of an cornea, then the femtosecond laser is closed, a 213 nanometer laser or a deep ultraviolet nanometer laser is started, the first reflecting mirror is adjusted to be a transmitting function, the laser beams are transmitted into the second laser transmission device through the first reflecting mirror, finally transmitted to the eyeball, and cutting treatment is conducted on the cornea.
2. The multi-wavelength medical laser system of claim 1, wherein the femtosecond laser is a high repetition rate femtosecond laser between 800 nanometers and 1100 nanometers.
3. The multi-wavelength medical laser system according to claim 1, wherein the deep ultraviolet nano laser is a Nd: YAG frequency-doubled 213 nanometer pulse laser, and the solid laser is subjected to frequency conversion to generate a deep ultraviolet pulse laser with a wavelength between 190 nm and 213 nm.
4. The multi-wavelength medical laser system of claim 1, wherein the first laser delivery device comprises a beam compensator, a mirror, a beam expander, and a beam homogenizer.
5. The multi-wavelength medical laser system of claim 1, wherein the second laser delivery device comprises an X-Y scanning mirror and a focusing lens.
6. The multi-wavelength medical laser system according to claim 1, wherein the femtosecond laser is a fiber laser, the pulse energy is 1 μj, the pulse width is 300fs, the pulse frequency is less than 4MHz, and the cooling mode is air cooling.
7. The multi-wavelength medical laser system of claim 6, wherein the laser beam generated by the fiber laser has a spot diameter of 3 μm and a focusing energy of 150 nJ/pulse.
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| US6258082B1 (en) * | 1999-05-03 | 2001-07-10 | J. T. Lin | Refractive surgery and presbyopia correction using infrared and ultraviolet lasers |
| CN102355875A (en) * | 2009-03-17 | 2012-02-15 | 威孚莱有限公司 | Laser device for ophthalmology |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP3164236B2 (en) * | 1991-10-04 | 2001-05-08 | 株式会社ニデック | Light therapy equipment |
| US5752950A (en) * | 1994-04-25 | 1998-05-19 | Autonomous Technologies Corp. | System for automatically inhibiting ophthalmic treatment laser |
| KR101118146B1 (en) * | 2009-12-04 | 2012-03-12 | 한국표준과학연구원 | Apparatus for the Treatment of Ocular Diseases and Apparatus for the Diagnosis of Ocular Diseases |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258082B1 (en) * | 1999-05-03 | 2001-07-10 | J. T. Lin | Refractive surgery and presbyopia correction using infrared and ultraviolet lasers |
| CN102355875A (en) * | 2009-03-17 | 2012-02-15 | 威孚莱有限公司 | Laser device for ophthalmology |
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