CN118319602B - All-solid cornea operation system under SSOCT monitoring guidance - Google Patents

Abstract

The invention provides an all-solid cornea operation system under SSOCT monitoring and guiding, and relates to the technical field of medical equipment. According to the all-solid cornea operation system under the SSOCT monitoring guidance provided by the embodiment of the invention, a multi-wavelength medical laser system is combined with the SSOCT monitoring technology, real-time and high-resolution eye images can be provided in the operation process, and the operation can be more accurately performed based on the system, so that errors and risks are avoided. In the embodiment of the invention, detailed eye anatomy structure information including a plurality of parameters such as cornea morphology, thickness and the like can be acquired through SSOCT monitoring, so that the operation process can be personalized adjusted according to individual characteristics of a patient, and the operation effect and prognosis are improved. The all-solid cornea operation system under the guidance of SSOCT monitoring can better control risks in the operation process by monitoring the condition of eyes in real time. The control in the aspects of cutting depth, cornea structure stability and the like can reduce the operation risk to the greatest extent.

Description

All-solid cornea operation system under SSOCT monitoring guidance

Technical Field

The embodiment of the invention relates to the technical field of medical equipment, in particular to an all-solid cornea operation system under the guidance of SSOCT monitoring.

Background

According to World Health Organization (WHO) data, 10 million people's vision impairment origins can be prevented or remain to be solved in 2020, wherein the prevention and treatment rate is required to be improved for 6520 ten thousand cataracts, 6900 ten thousand glaucoma and the like. Of the causes of blindness, cataract accounts for 9% and glaucoma accounts for 10%, both of which are the main causes of blindness and vision impairment worldwide. The number of ophthalmic beds in ophthalmic hospitals and health institutions in China is continuously increased, and the purchasing demand of ophthalmic microscopes is directly promoted. Compared with foreign ophthalmic microscope products, the domestic product has obvious price advantage, which is beneficial to reducing the operating cost of hospitals and the hospitalizing cost of patients. But in the field of high-end products, domestic products have larger competitive disadvantages in terms of public praise and quality.

In the prior art, the treatment or diagnosis of the eye is generally carried out using individual instruments whose design is adapted to the respective application purpose. For example, if refractive errors are to be corrected by laser surgery on the cornea of an eye, first an instrument suitable for diagnosing the eye is used, such as using a slit lamp, an optical arrangement for three-dimensional measurement of the cornea, an arrangement for optical coherence tomography, etc. The results achieved with such diagnostic instruments are then used to determine the measure of treatment, and the instrument that is available for treatment is selected and prepared. In the treatment, a flap-like cover (Deckel), called a "flap", is first formed on the corneal surface by means of a so-called "flap knife (FLAPSCHNEIDE)" laser (also known as a laser keratome, or microkeratome in its mechanical variant), the thickness of which is significantly smaller than the thickness of the cornea, before the surgery to correct refractive errors. In order to be able to produce such flap caps as precisely as possible, laser keratomes have been used in the prior art which produce a therapeutic laser beam with a pulse width of less than 10 ^-12 s. Thus, a locally limited breakdown (Durchbruch) with an extension of only a few micrometers is achieved in the cornea. By purposefully arranging a plurality of such breakdowns together, the desired "skin flap" can be constructed and rendered reversible. After the "flap" is created, tissue is resected from the exposed interior region of the cornea in the inverted "flap" using another instrument for the purpose of correcting refractive errors. The ablation operation in turn needs to be performed by introducing energy by means of a pulsed therapeutic laser beam, which may be from an excimer laser. Diagnostic instrumentation is also often required after treatment in order to be able to evaluate the treatment outcome and to be able to schedule subsequent treatments if necessary.

It follows that the order of the instruments used for diagnosing or treating the eye must be carefully considered during the treatment, wherein in particular the identification data, diagnosis data and/or treatment data relating to the patient and the configuration data or protocol data and control signals relating to the treatment are taken into account, so that the doctor or user who is taking the treatment can make the necessary adjustments for the treatment or diagnosis on the respectively used instruments. The patient also needs to be repositioned from instrument to instrument or the individual instruments need to be moved to align the patient's eyes for diagnosis or treatment.

In the prior art, since the instruments used are typically separate from each other, it is necessary to transport the patient from one instrument to the next during the treatment. However, this alone does not guarantee the exact positioning necessary for the treatment or diagnosis on the respective instrument. Since the geometry of the instruments is not consistent with each other, it is not only necessary to transport the patient between the instruments, but also to adjust the position of the patient according to the corresponding instrument design.

Disclosure of Invention

Optical coherence tomography (Swept-Source Optical Coherence Tomography, SSOCT) is a non-contact imaging modality capable of detecting backscattered photons from tissue having high sensitivity and micrometer-scale spatial resolution. The advent of SSOCT fourier domain detection and its validation of sensitivity advantages over time domain techniques has facilitated a transition from real-time two-dimensional B-SCAN imaging to real-time three-dimensional volumetric imaging.

Based on the above, the embodiment of the invention provides an all-solid cornea operation system under the guidance of SSOCT monitoring, so that the whole process of the all-solid cornea operation is realized through an integrated operation system under the guidance of SSOCT monitoring.

The embodiment of the invention provides an all-solid cornea surgery system under the monitoring and guiding of SSOCT, which comprises an SSOCT system and a multi-wavelength medical laser system, wherein the multi-wavelength medical laser system comprises a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first reflecting mirror, a second laser transmission device, a positioning laser device eyeball tracking system and a surgical microscope, the deep ultraviolet nanometer laser generates laser with the wavelength of 190-213 nanometers, the femtosecond laser generates laser with the wavelength of 800-1100 nanometers, the laser with the wavelength of 190-213 nanometers is transmitted to the first reflecting mirror through the first laser transmission device, the laser with the wavelength of 800-1100 nanometers is transmitted to a first reflecting mirror through the large digital aperture focusing lens group, the laser with the first reflecting mirror is transmitted to a target position through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the tracking system and the surgical microscope, the laser is used for cutting an intermediate layer between 190-213 nanometers and the laser is used for cutting an angle between 800-1100 nanometers;

The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls working parameters of each component in the multi-wavelength medical laser system.

Optionally, the deep ultraviolet nano laser generates laser light with a wavelength of 213 nm, the femto-second laser generates laser light with a wavelength of 1053 nm, the first mirror reflects 1053 nm laser light in a first state and transmits 213 nm laser light, and the first mirror reflects 213 nm laser light and transmits 1053 nm laser light in a second state;

the SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, controls relevant parameters of each component in the multi-wavelength medical laser system, and comprises the following steps:

The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, controls the state of the first reflecting mirror, controls the working parameters of the femtosecond laser and controls the working parameters of the deep ultraviolet nanometer laser.

Optionally, the femtosecond laser is a high repetition rate femtosecond laser between 800 nanometers and 1100 nanometers.

Optionally, the deep ultraviolet laser is a Nd-YAG quintupled 213 nanometer pulse laser, and the solid laser is subjected to frequency conversion to generate the deep ultraviolet pulse laser with the wavelength between 190 nanometers and 213 nanometers.

Optionally, the first laser transmission device comprises a beam compensator, a reflector, a beam expander and a beam homogenizer.

Optionally, the second laser transmission device comprises an X-Y scanning mirror and a focusing lens.

Optionally, the femtosecond laser is an optical fiber laser, the pulse energy is 1 mu J, the pulse width is 300fs, the pulse frequency is less than 4MHz, and the cooling mode is air cooling.

Optionally, the spot diameter of the laser generated by the fiber laser is 3 μm, the focusing energy is 150 nJ/pulse, and the focusing range is 300 μm.

According to the all-solid cornea operation system under the SSOCT monitoring guidance, which is provided by the embodiment of the invention, the all-solid cornea operation system is combined with the SSOCT monitoring technology, real-time and high-resolution eye images can be provided in the operation process, and the operation can be more accurately performed based on the system, so that errors and risks are avoided. In the embodiment of the invention, detailed eye anatomy structure information including a plurality of parameters such as cornea morphology, thickness and the like can be acquired through SSOCT monitoring, so that the operation process can be personalized adjusted according to individual characteristics of a patient, and the operation effect and prognosis are improved. The all-solid cornea operation system under the guidance of SSOCT monitoring can better control risks in the operation process by monitoring the condition of eyes in real time. The control in the aspects of cutting depth, cornea structure stability and the like can reduce the operation risk to the greatest extent.

In the all-solid cornea operation system under the monitoring and guiding of the SSOCT provided by the embodiment of the invention, the multi-wavelength medical laser system can control the state conversion of the first reflecting mirror under the monitoring and guiding of the SSOCT, the first reflecting mirror reflects 1053 nm laser and transmits 213 nm laser or the first reflecting mirror reflects 213 nm and transmits 1053 nm, so that the cornea can be precisely cut by using 213 nm laser and the 1053 nm laser can be cut in the cornea intermediate layer by using one instrument, a plurality of instruments are not needed in the treatment process, the patient is not needed to be transferred, the treatment process can be simplified, and the treatment efficiency is improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments of the present invention will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 shows a schematic structural diagram of an all-solid cornea surgery system under the guidance of SSOCT monitoring according to an embodiment of the present invention;

Fig. 2 shows a schematic structural diagram of a multi-wavelength medical laser system in an all-solid-state cornea surgery system under the guidance of SSOCT monitoring according to an embodiment of the present invention.

Detailed Description

In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.

In the embodiment of the invention, an all-solid cornea operation system under SSOCT monitoring guidance is provided, as shown in fig. 1, which shows a structural schematic diagram of the all-solid cornea operation system under SSOCT monitoring guidance provided by the embodiment of the invention, and specifically, the system comprises an SSOCT system and a multi-wavelength medical laser system. In the embodiment of the invention, a structural schematic diagram of a multi-wavelength medical laser system in an all-solid cornea operation system under the guidance of SSOCT monitoring is further provided, as shown in fig. 2, specifically, the multi-wavelength medical laser system comprises a femto-second laser, a large-digital-aperture focusing lens group, a deep-ultraviolet nano laser, a beam compensator, a first laser transmission device, a first reflecting mirror, a second laser transmission device, a positioning laser device eyeball tracking system and an operation microscope, wherein the deep-ultraviolet nano laser generates laser with the wavelength of 190-213 nanometers, the femto-second laser generates laser with the wavelength of 800-1100 nanometers, the laser with the wavelength of 190-213 nanometers is transmitted to the first reflecting mirror through the first laser transmission device, the laser with the wavelength of 800-1100 nanometers is transmitted to a first reflecting mirror through the large-digital-aperture focusing lens group, the laser with the first reflecting mirror passes through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the tracking system and the operation microscope, the femto-second laser transmission device generates laser with the wavelength of 800-213 nanometers, and the laser with the wavelength of 800-213 nanometers is used for cutting the cornea at the angle of 800-1100 nanometers.

The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls working parameters of each component in the multi-wavelength medical laser system.

In embodiments of the present invention, SSOCT is a non-invasive imaging technique for imaging ocular structures. Which uses a laser light source to emit a beam of near infrared light and generates a high resolution eye image by measuring the reflection of the beam. SSOCT can provide detailed information about ocular structures such as retina, vitreous, optic nerve, cornea, and the like. SSOCT systems use swept sources to provide faster imaging speeds and higher resolution. The SSOCT system uses a swept source to emit a series of wave packets, resulting in higher speed and resolution.

In a specific application process, the SSOCT system can provide real-time eye images, help doctors to accurately position operation areas and structures, conduct accurate operation planning and operation, and can output control signals based on the real-time eyeball images to control working parameters of various components in the multi-wavelength medical laser system.

In the embodiment of the invention, the SSOCT system can avoid causing additional damage to eye tissues while imaging at high speed, and particularly, the SSOCT is a non-invasive imaging technology, imaging is performed by using an optical principle, and the SSOCT system does not need to be in direct contact with eyeballs or eye tissues. This means that the SSOCT system does not directly cause physical damage to the eye tissue when performing surgery. Furthermore, SSOCT systems can provide faster imaging speeds using swept source technology. This means that the time for image acquisition is very short, reducing the exposure time to eye tissue and thus reducing the risk of additional damage. In addition, the SSOCT system has the advantage of high resolution, and can provide clear and detailed high resolution imaging eye images. This allows the physician to more accurately view the ocular structures and avoid mishandling or unnecessary damage to surrounding tissue. Therefore, the SSOCT system ensures that the eye tissue is prevented from being additionally damaged while the high-speed imaging is performed through non-invasive imaging, rapid imaging and high-resolution imaging, and can accurately guide the multi-wavelength medical laser system to perform cutting treatment on the cornea and perform cutting on the intermediate layer of the cornea.

In the embodiment of the invention, the SSOCT system can also provide real-time eye images, and a doctor can observe eye structures through a monitoring screen in the operation process. This allows the surgeon to accurately locate the surgical field and structure and make adjustments in time. In particular, high resolution imaging of SSOCT systems can clearly reveal ocular anatomy, including retina, vitreous, optic nerve, cornea, and the like. From these image information, the doctor can understand the state and position of the eye tissue, thereby guiding the surgical operation. The SSOCT system also has guide marking and measurement functions that the physician can mark and measure on the image to help determine the surgical position and angle, which can provide a quantitative reference that makes the surgical procedure more accurate.

In the embodiment of the invention, the SSOCT system can reconstruct a three-dimensional image of the eye structure, and a doctor can acquire a more comprehensive visual field by rotating and magnifying the image. The method helps doctors to better understand the spatial relationship of the eye structures and perform more accurate operation planning and operation.

In the embodiment of the invention, the femtosecond laser can be specifically a high repetition frequency femtosecond laser between 800 nanometers and 1100 nanometers.

In the embodiment of the invention, the deep ultraviolet laser is a 213 nanometer pulse laser with Nd: YAG frequency doubling, and can generate the deep ultraviolet pulse laser with the wavelength of 190-213 nanometers by using a solid laser through a frequency conversion technology.

In the practical application process, one of the 213 nanometer laser or the deep ultraviolet nanometer laser is selected at will.

In the practical application process, the first reflecting mirror has two states, wherein the first state can transmit 213 nanometers of laser to the second laser transmission device, and the second state can transmit 1053 nanometers of femtosecond laser to the second laser transmission device.

Alternatively, the first state of the first mirror may reflect 1053 nm laser light and transmit 213 nm laser light, and the second state of the first mirror may reflect 213 nm and transmit 1053 nm.

In this case, in the practical application process, the first mirror may be set to the second state by default, and even if one or more of the two lasers are started, the laser light does not reach the eyeball position, so that misoperation may be avoided. In the operation process of the operation, the femtosecond laser can be started first, the first reflecting mirror is set to be in a second state, 1053 nanometer femtosecond laser generated by the femtosecond laser reaches the eyeball position through reflection of the first reflecting mirror, accurate cutting of the cornea intermediate layer is completed under the monitoring and guiding of SSOCT, after the cutting of the cornea intermediate layer is confirmed to be completed under the monitoring and guiding of SSOCT, a control signal is output, the state of the first reflecting mirror is controlled, the deep ultraviolet nanometer laser is started, and 213 nanometer laser generated by the deep ultraviolet nanometer laser is transmitted to the eyeball position through the first reflecting mirror, and cutting treatment is performed on the cornea.

In the embodiment of the invention, the eyeball tracking system can monitor the position and the movement of the eyeball in real time so as to ensure that the laser irradiates at the correct position. The eye tracking system may further help reduce errors in surgery and improve the accuracy and safety of the surgery.

Alternatively, the first state of the first mirror may be transmissive to 213 nm laser light and the second state may be reflective to 1053 nm laser light.

Under the condition, in the practical application process, the femtosecond laser can be controlled to be started first, the first reflecting mirror is controlled to be adjusted to have a reflecting function, then the laser beam generated by the femtosecond laser is reflected into the second laser transmission device through the first reflecting mirror and finally transmitted to the eyeball, cutting is carried out on the middle layer of the cornea of the eyeball, and then the femtosecond laser is controlled to be closed. And controlling the 213 nanometer laser or the deep ultraviolet nanometer laser to start, controlling the first reflecting mirror to adjust the laser beam into a transmission function, transmitting the laser beam into the second laser transmission device through the first reflecting mirror, and finally transmitting the laser beam to the eyeball to cut the cornea.

Specifically, the first reflecting mirror may be a lens with two sides having different curvatures, so that one side reflects the received light beam, and the other side transmits the received light beam, and in practical application, the first reflecting mirror may be turned over and angle adjusted to implement the conversion between the two states.

Specifically, the first reflecting mirror can also form a lens system by using a plurality of lenses, and the conversion of the two states is realized by adjusting parameters such as the number, the position, the curvature and the like of the lenses.

In embodiments of the present invention, the large numerical aperture focusing lens group functions to focus the beam onto a very small spot or area. Such lens groups are typically composed of a plurality of lenses to achieve more complex optical functions.

Specifically, the roles of a large numerical aperture focusing lens group include:

high numerical aperture-large numerical aperture means that the diameter and focal length of the lens are relatively large, which means that a larger range of incident light can be received. This design allows the focusing lens group to collect more light and to handle larger angles of incidence, improving the collection efficiency of the light and the luminous flux of the lens system.

High resolution the large numerical aperture focusing lens group can provide higher resolution, i.e. can focus light more clearly, resulting in a smaller size of the focal point. This is important for applications requiring high precision imaging or high resolution, such as microscopy, laser writing, optical sensors, etc.

Optical correction the focusing lens group can correct optical distortion by combining lenses of different curvatures and shapes. This includes spherical aberration, chromatic aberration, and the like. By optimizing the design and combination of the lens groups, better optical performance can be achieved, and imaging quality and definition of the focusing point can be improved.

Beam shape adjustment the large numerical aperture focusing lens group can also adjust the shape of the beam by the shape and combination of lenses. For example, by using an aspherical lens or a non-uniform lens curvature, adjustment of the beam shape, such as converting a circular beam into an elliptical beam, can be achieved.

In the embodiment of the invention, the second laser transmission device comprises an X-Y scanning mirror and a focusing lens.

In the embodiment of the invention, the femtosecond laser is an optical fiber laser, the pulse energy is 1 mu J, the pulse width is 300fs, the pulse frequency is less than 4MHz, and the cooling mode is air cooling.

In the embodiment of the invention, the diameter of a light spot of laser generated by the fiber laser is 3 mu m, the focusing energy is 150 nJ/pulse, and the focusing range is 300 mu m.

In embodiments of the present invention, the X-Y scanning mirror is a component commonly used in optical systems and laser technology. The laser beam positioning and orientation device consists of two mirrors which are perpendicular to each other, one is used for the horizontal direction (X axis) and the other is used for the vertical direction (Y axis), and by controlling the movement of the two mirrors, the accurate positioning and orientation of the laser beam can be realized. The primary function of the X-Y scanning mirror is to change the direction and position of the beam. By controlling the angle and speed of the scanning mirror, the beam can be scanned, focused, deflected and positioned on a plane.

The focusing lens in the multi-wavelength medical laser system provided by the embodiment of the invention can focus the light beam to a smaller point or area, and the focusing lens can change the propagation direction of the light beam and the intensity distribution of the light beam, so that the light beam becomes more concentrated and powerful.

Specifically, the focusing lens mainly has the following functions:

Focusing the focusing lens focuses the parallel incident beam to a focal point. The focal length of the beam and the position of the focal point can be controlled by changing the relative position of the lens to the beam or adjusting the curvature of the lens.

Beam shape adjustment-the focusing lens may change the shape of the laser beam, e.g. to convert a circular beam into an elliptical beam.

Beam adjustment-the focusing lens can adjust the diameter and divergence angle of the beam. By varying the aperture and curvature of the lens, the degree of divergence or focusing of the beam can be controlled.

Optical correction-the focusing lens may also be used to correct optical distortions in the light beam. For example, spherical lenses can correct spherical aberration, thereby maintaining better quality and sharpness of the focal point of the beam during focusing.

Specifically, in the practical application process, the working parameters of the large digital aperture focusing lens group, the X-Y scanning mirror and the focusing lens can be controlled based on the real-time eyeball image obtained by the SSOCT system, so as to adjust the direction, the position, the diameter, the divergence angle and the like of the laser beam reflected by the first reflecting mirror, and make the laser beam meet the operation requirement.

In the embodiment of the invention, the first laser transmission device comprises a beam compensator, a reflector, a beam expander and a beam homogenizer.

In an embodiment of the invention, the beam compensator is a device for adjusting the focal point position of the laser beam inside the eye. The device has the effects of correcting errors generated when light beams are refracted in eyeballs due to factors such as cornea morphology, diopter and the like, ensuring that laser can be accurately focused on the eyeballs, and further realizing accurate and effective treatment effects. The technique can greatly reduce the risk of operation and improve the success rate of operation and the treatment experience of patients.

In the embodiment of the invention, the beam expander can adjust and limit the diameter and the shape of the 213 nanometer laser beam. The beam expander plays a role in focusing and controlling the laser beam so that the laser beam can be accurately irradiated to a specific part of the eyes of the patient, thereby realizing an accurate treatment effect.

In the embodiment of the invention, the beam expander can ensure the focusing degree and accuracy of the laser beam, improve the safety and accuracy of the operation, limit the diameter of the laser beam within a smaller range, ensure that the laser beam can be accurately concentrated in a specific area of the eye, and simultaneously can also furthest protect surrounding tissues from unnecessary injury. By reasonably adjusting and using the beam expander, a doctor can better control the intensity and the focusing range of the laser, thereby effectively performing various ophthalmic surgical treatments.

In the embodiment of the invention, the beam expander can also help control the energy density of the laser, so as to ensure that the laser generates proper thermal effect in eye tissues to achieve the expected treatment effect.

In the embodiment of the invention, the beam expander is generally composed of a high-quality optical element, so that the quality and stability of the laser beam can be maintained.

In the embodiment of the invention, the beam homogenizer can adjust the intensity distribution of the laser beam so that the laser beam can uniformly cover the whole target area when the eye tissue of a patient is treated. Thus, the patient can be ensured to receive uniform laser energy, and the accuracy and safety of the operation are improved. Beam homogenizers are typically manufactured using special optical designs and materials to ensure that the laser beam is effectively homogenized as it passes through the device. In addition, the beam homogenizer can also help to adjust the diameter and shape of the laser beam to meet different surgical needs.

In the embodiment of the invention, in the application process of the multi-wavelength medical laser system, doctors can acquire real-time eyeball images under the observation of an operation microscope based on the cooperation of the eyeball tracking system and in combination with the SSOCT system, and the working parameters of the beam compensator, the beam expander and the beam homogenizer are controlled so as to finish the adjustment of the shape, the position, the focal power and the intensity of the laser beam, so that the device is suitable for the needs of patients.

In the embodiment of the invention, 213 nanometer laser or deep ultraviolet laser generated by a 213 nanometer laser or deep ultraviolet nanometer laser can be adjusted based on the mutual coordination of a beam compensator, a beam expander and a beam homogenizer to obtain laser beams which are suitable for the actual condition of a patient, and the laser beams are transmitted out through a first reflector and then transmitted to the cornea of an eyeball through an X-Y scanning mirror and a focusing lens, so that cornea cutting is completed.

In the embodiment of the invention, in the transmission process of the 213 nanometer laser beam, the related parameters of the X-Y scanning mirror and the focusing lens in the second laser transmission device can be fixed, and the related parameters of the beam compensator, the reflector, the beam expander and the beam homogenizer in the first laser transmission device are adjusted so as to enable the shape, the position, the focusing power and the intensity of the 213 nanometer laser beam to meet the actual requirements.

The multi-wavelength medical laser system provided by the embodiment of the invention can reflect laser generated by the femtosecond laser by the first reflector, can transmit laser generated by the 213 nanometer or deep ultraviolet nanometer laser, can cut cornea by using 213 nanometer laser and can cut cornea intermediate layer by using femtosecond solid laser by one instrument, does not need to use a plurality of instruments in treatment process, does not need to transfer patients, can simplify treatment process and improve treatment efficiency.

In the embodiment of the invention, the SSOCT system not only can acquire real-time eyeball images in the operation process and output control signals based on the real-time eyeball images to control the working parameters of each component in the multi-wavelength medical laser system, but also can provide detailed information of an eye anatomy structure in the pre-operation evaluation stage so as to help doctors to perform operation planning and pre-operation simulation, and can also be used for checking operation results and monitoring recovery conditions of patients after operation.

The embodiment of the invention also provides a control method of the all-solid cornea operation system under the monitoring and guiding of the SSOCT, which comprises the following steps:

starting an SSOCT system to acquire a real-time eyeball image, and outputting working parameters aiming at a femtosecond laser, a large-digital-aperture focusing lens group and a second laser transmission device based on the real-time eyeball image;

and 2, controlling the start of the femtosecond laser, and controlling the large digital aperture focusing lens group and the X-Y scanning mirror and the focusing lens in the second laser transmission device to work according to the working parameters determined in the step 1.

And 3, controlling the femtosecond laser to emit laser, and cutting the interlayer of the cornea of the eye.

And 4, controlling the femto-second laser to be turned off, controlling the deep ultraviolet nano laser to be started, controlling the first reflecting mirror to convert the working state, and outputting working parameters of the beam compensator, the reflecting mirror, the beam expander and the beam homogenizer in the first laser transmission device based on the real-time eyeball image.

And 5, controlling the deep ultraviolet nanometer laser to emit laser, and cutting the cornea.

The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.

The previous description of the inventive aspects is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these aspects will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other aspects without departing from the scope of the invention. Thus, the present invention is not intended to be limited to the aspects shown herein but is to be accorded the widest scope consistent with the principles and novel features herein.

The foregoing description has been presented for purposes of illustration and description. Furthermore, this description is not intended to limit embodiments of the invention to the form disclosed herein. Although a number of example aspects and embodiments have been discussed above, a person of ordinary skill in the art will recognize certain variations, modifications, alterations, additions, and subcombinations thereof.

Claims (7)

1. The all-solid cornea operation system under the monitoring and guiding of the SSOCT is characterized by comprising an SSOCT system and a multi-wavelength medical laser system, wherein the multi-wavelength medical laser system comprises a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nanometer laser, a beam compensator, a first laser transmission device, a first reflecting mirror, a second laser transmission device, a positioning laser device eyeball tracking system and an operation microscope, the deep ultraviolet nanometer laser generates laser with the wavelength of 190-213 nanometers, the femtosecond laser generates laser with the wavelength of 800-1100 nanometers, the laser with the wavelength of 190-213 nanometers is transmitted to the first reflecting mirror through the first laser transmission device, the laser with the wavelength of 800-1100 nanometers is transmitted to a first reflecting mirror through the large digital aperture focusing lens group, the laser with the first reflecting mirror is transmitted to a target position through the second laser transmission device, the positioning laser device adjusts the position of the laser based on the tracking system and the operation microscope, the laser with the positioning laser device is used for cutting an interlayer between 190-213 nanometers, and the laser with the angle between the 190-213 nanometers is used for cutting an interlayer between the eye films with the wavelength of 800 nanometers;

The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls working parameters of each component in the multi-wavelength medical laser system;

The deep ultraviolet nano laser generates laser with the wavelength of 213 nanometers, the femto-second laser generates laser with the wavelength of 1053 nanometers, the first reflecting mirror reflects the 1053 nanometer laser in a first state and transmits the 213 nanometer laser, and the first reflecting mirror reflects the 213 nanometer laser in a second state and transmits the 1053 nanometer laser;

The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, controls working parameters of each component in the multi-wavelength medical laser system, and comprises the following steps:

The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, controls the state of the first reflecting mirror, controls the working parameters of the femtosecond laser and controls the working parameters of the deep ultraviolet nanometer laser;

In the application process of the all-solid cornea operation system, a first reflecting mirror is set to be in a second state, at the moment, even if one or more of two lasers are started, laser does not reach the eyeball position, misoperation is avoided, in the operation process of operation, a femtosecond laser is started first, the first reflecting mirror is set to be in the second state, 1053 nanometer femtosecond laser generated by the femtosecond laser reaches the eyeball position through reflection of the first reflecting mirror, precise cutting of an cornea intermediate layer is completed under SSOCT monitoring and guiding, after cutting of the cornea intermediate layer is confirmed under SSOCT monitoring and guiding, a control signal is output, the state of the first reflecting mirror is controlled, and a deep ultraviolet nanometer laser is started, so that 213 nanometer laser generated by the deep ultraviolet nanometer laser reaches the eyeball position through transmission of the first reflecting mirror, and cutting treatment is performed on the cornea.

2. The SSOCT monitoring guided all-solid-state corneal surgery system of claim 1, wherein the femtosecond laser is a high repetition rate femtosecond laser between 800 nanometers and 1100 nanometers.

3. The SSOCT monitoring guided all-solid-state corneal surgery system according to claim 1, wherein the deep ultraviolet nanolaser is a nd:yag quintupled 213 nm pulsed laser, and the solid laser is converted to generate a deep ultraviolet pulsed laser with a wavelength between 190 nm and 213 nm.

4. The multi-wavelength medical laser system of claim 1, wherein the first laser delivery device comprises a beam compensator, a mirror, a beam expander, and a beam homogenizer.

5. The SSOCT monitoring guided all-solid-state corneal surgery system of claim 1, wherein the second laser delivery device comprises an X-Y scanning mirror and a focusing lens.

6. The SSOCT monitoring guided all-solid-state corneal surgery system according to claim 1, wherein the femtosecond laser is a fiber laser, the pulse energy is 1 μj, the pulse width is 300fs, the pulse frequency is less than 4MHz, and the cooling mode is air cooling.

7. The SSOCT monitoring guided total solid state corneal surgery system according to claim 4, wherein the laser beam generated by the fiber laser has a spot diameter of 3 μm and a focusing energy of 150 nJ/pulse.