CN117899361A - A wireless, power-free implantable probe based on thermoelectric materials - Google Patents

Abstract

The invention relates to the technical field of nerve probes, and provides a wireless and powerless implantation type probe based on a thermoelectric material, which comprises a cold source part, a heat source part, a thermoelectric interlayer and a probe main body, wherein the cold source part is used for being attached to a cold source; the heat source part and the cold source part are relatively fixed and are used for attaching a heat source, the heat source part comprises a substrate, a wireless transmission module and a control module, and the wireless transmission module is electrically connected with the control module and is arranged on the substrate. The wireless and powerless implanted probe based on the thermoelectric material is characterized in that a cold source part, a heat source part and a thermoelectric interlayer are arranged, the cold source part and the heat source part are respectively contacted with the cold source and the heat source to perform heat exchange, and a temperature difference is formed at two ends of the thermoelectric interlayer to form a potential difference on the thermoelectric interlayer so as to supply power for a wireless transmission module and a control module, so that the control module can perform wireless communication with a user side, and meanwhile, a stimulation module is driven by the control module to form a stimulation source to perform nerve stimulation on an animal model.

Description

A wireless, power-free implantable probe based on thermoelectric materials

Technical Field

The present invention relates to the technical field of neural probes, and in particular to a wireless, power-free implantable probe based on thermoelectric materials.

Background technique

Advances in electronic, optoelectronic, and microfluidic interfacing technologies for living biological systems have laid the foundation for multifunctional devices that can modulate the central and peripheral nervous systems. In addition to their use in basic research, neural tissue interfaces are also being developed for the treatment of neurological disorders and diseases. Implantable neural interfaces expand the design and capabilities of existing miniaturized systems to support real-time control of user-programmed optical, chemical, and electrical stimulation. Implantable neural interfaces are similar to cochlear implants and pacemakers, and can use the rigid combination of electronic modules of devices such as probes as interfaces to neuronal collections. Neural interfaces in conjunction with other systems (such as deep brain stimulation) can monitor and improve various psychiatric disorders, especially depression, epilepsy, chronic pain, deafness, and Parkinson's disease.

Neural tissue interfaces are usually configured with wired communication and active power supply. Wired and battery power supply will increase the weight and volume of the neural tissue interface, restrict the natural movement of animals, hinder social interaction in animal models, and limit the application of neural tissue interfaces and corresponding systems in behavioral neuroscience research. For example, a cochlear implant converts sound into electrical signals in a certain coded form through an external speech processor, and directly stimulates the auditory nerve through an electrode system implanted in the body to restore, improve and reconstruct the hearing function of the deaf. However, since the battery needs to be replaced every 3-5 days, in order to facilitate user operation, it will be magnetically attached for users to wear and operate. However, the external processor of the cochlear implant is easy to fall and lose, which also imposes great restrictions on the user's activities.

Summary of the invention

In view of this, the present invention proposes a wireless, power-free implantable probe based on thermoelectric materials. Wireless implantable devices can provide powerful, durable and high-fidelity interfaces for the central and peripheral nervous systems. These interfaces and supporting platforms enhance the repeatability of experiments and reduce the interaction between test subjects and environmental obstacles. At the same time, wireless devices can significantly improve the accuracy of research results by minimizing the impact on the movement of experimental animals.

The technical solution of the present invention is implemented as follows: The present invention provides a wireless, power-free implantable probe based on thermoelectric materials, comprising a cold source portion, a heat source portion, a thermoelectric interlayer and a probe body, wherein:

The cold source part is used for attaching the cold source;

The heat source part and the cold source part are relatively fixed and used to fit the heat source. The heat source part includes a substrate, a wireless transmission module and a control module. The wireless transmission module and the control module are electrically connected and are both arranged on the substrate. The wireless transmission module is used to enable the control module to communicate with the user end. A microfluidic channel is arranged on the substrate.

The thermoelectric interlayer is arranged between the cold source part and the hot source part, and is electrically connected to the wireless transmission module and the control module. The thermoelectric interlayer is used to form a voltage by carrier migration under the temperature difference between the cold source part and the hot source part, so as to supply power to the wireless transmission module and the control module.

The probe body is fixed on the heat source part. A drug administration channel is opened on the probe body. The drug administration channel is connected to the microfluidic channel and is used for local drug administration to the animal model. The probe body includes a stimulation module. The stimulation module is electrically connected to the control module and is used to stimulate the local nerves of the animal model.

On the basis of the above technical solution, preferably, the thermoelectric interlayer comprises a silicon substrate, an alloy thin layer and an interface, wherein:

Two ends of the silicon substrate are respectively fixed to the heat source part and the cold source part;

Two ends of the alloy thin layer are respectively fixed to the heat source part and the cold source part, and the alloy thin layer is compositely fixed to the silicon substrate;

An interface is formed between the silicon substrate and the alloy thin layer, and the interface is used for heat conduction between the silicon substrate and the alloy thin layer.

On the basis of the above technical solution, preferably, the thermoelectric interlayer includes a positive terminal and a negative terminal, the positive terminal is fixed to the heat source part and is electrically connected to the wireless transmission module and the control module, and the negative terminal is fixed to the cold source part and is electrically connected to the wireless transmission module and the control module to form a complete current loop.

Further preferably, the heat source part also includes a positive electrode sheet, which is arranged on the substrate, and the positive end of the thermoelectric interlayer is electrically connected to the wireless transmission module and the control module through the positive electrode sheet; the cold source part includes a negative electrode sheet, and the negative end of the thermoelectric interlayer is electrically connected to the wireless transmission module and the control module through the negative electrode sheet.

More preferably, there are multiple thermoelectric interlayers, and the array is arranged between the cold source part and the heat source part, the positive end of each thermoelectric interlayer is electrically connected to the positive electrode sheet, and the negative end of each thermoelectric interlayer is electrically connected to the negative electrode sheet.

On the basis of the above technical solution, preferably, the heat source part also includes a voltage stabilizing module, the voltage stabilizing module is arranged on the substrate, the voltage stabilizing module includes a voltage stabilizing input end and a voltage stabilizing output end, the voltage stabilizing input end is electrically connected to the thermoelectric interlayer, the voltage stabilizing output end is electrically connected to the wireless transmission module and the control module, and the voltage stabilizing module is used to stabilize the voltage formed on the thermoelectric interlayer and output it to the wireless transmission module and the control module.

On the basis of the above technical solution, preferably, the control module includes a micro control unit and a power adjustment unit, wherein:

The micro control unit is electrically connected to the wireless transmission module, and the micro control unit is used to output a control signal;

The power regulating unit has a control end, a power input end and a load end. The control end is electrically connected to the microcontroller unit, and the control end is used to receive a control signal sent by the microcontroller unit. The power input end is electrically connected to the thermoelectric interlayer, and the load end is electrically connected to the stimulation module. The power regulating unit is used to adjust the power of the stimulation module.

On the basis of the above technical solution, preferably, the stimulation module includes an LED stimulation unit, the LED stimulation unit is electrically connected to the thermoelectric interlayer, and the LED stimulation unit is used to emit LED light to stimulate local nerves of the animal model.

On the basis of the above technical solution, preferably, the stimulation module comprises an ultrasonic stimulation unit, the ultrasonic stimulation unit is electrically connected to the thermoelectric interlayer, and the ultrasonic stimulation unit is used to emit ultrasonic waves to stimulate local nerves of the animal model.

On the basis of the above technical solution, preferably, the stimulation module includes an electrical signal stimulation unit, the electrical signal stimulation unit is electrically connected to the thermoelectric interlayer, and the electrical signal stimulation unit is used to send electrical signals to stimulate local nerves of the animal model.

The wireless, power-free implantable probe based on thermoelectric materials of the present invention has the following beneficial effects compared with the prior art:

(1) By setting a cold source part, a hot source part and a thermoelectric interlayer, and making the cold source part and the hot source part contact the cold source and the hot source respectively for heat exchange, a temperature difference is formed at the two ends of the thermoelectric interlayer, so that an electric potential difference is formed on the thermoelectric interlayer, and power is supplied to the wireless transmission module and the control module, so that the control module can communicate wirelessly with the user end, and at the same time, the control module drives the stimulation module to form a stimulation source to perform neural stimulation on the animal model. This wireless passive setting can provide a powerful, durable and high-fidelity interface for the central and peripheral nervous systems. These interfaces and supporting platforms enhance the repeatability of the experiment and reduce the interaction between the test subject and the environmental obstacles. In comparison with wired optogenetics equipment and battery-powered wireless optogenetics measurement equipment, wireless implantable devices have obvious advantages. In many cases, wired devices can significantly hinder the social behavior and overall activities of animals, while wireless devices can significantly improve the accuracy of research results by minimizing the impact on the movement of experimental animals.

(2) A plurality of thermoelectric interlayers are arranged in an array, and corresponding positive and negative electrodes are arranged on the heat source and the cold source to connect the two ends of the plurality of thermoelectric interlayers, so that each thermoelectric interlayer forms an electrical connection relationship, providing a stable voltage and current output to meet the passive power supply requirements of the device. At the same time, a voltage stabilizing module is provided, which is first boosted by a boost switching regulator and outputs a stable high voltage. The high voltage is then input into a series Zener voltage divider regulator, and is output after being stepped down and stabilized by the Zener shunt regulator, thereby obtaining a stable voltage that meets the system operation requirements.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

FIG1 is a perspective view of a wireless, power-free implantable probe based on thermoelectric materials of the present invention;

FIG2 is a partial cross-sectional view of a heat source portion of a wireless, power-free implantable probe based on thermoelectric materials according to the present invention;

FIG3 is a structural diagram of a thermoelectric interlayer of a wireless, power-free implantable probe based on thermoelectric materials according to the present invention;

4 is a partial cross-sectional view of the probe body of the wireless, power-free implantable probe based on thermoelectric materials of the present invention.

Detailed ways

The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

As shown in FIGS. 1-4 , the wireless, power-free implantable probe based on thermoelectric materials of the present invention includes a cold source portion 1 , a heat source portion 2 , a thermoelectric interlayer 3 and a probe body 4 .

The cold source part 1 is used to fit the cold source. The cold source part 1 is preferably an engineering plastic, and specifically can be made of PT material, i.e. polyethylene terephthalate, which has good mechanical properties and heat resistance, and a high heat deformation temperature, and can be used for a long time at a high temperature without deformation. In addition, the corrosion resistance of polyethylene terephthalate is also very good, and it has good corrosion resistance to some chemical substances. The cold source described in this embodiment can be a cold compress gel sheet. Before use, the cold compress gel sheet is attached to the cold source part 1 to dissipate heat from the cold source part 1, so that it is always at a lower temperature than the body temperature of the animal model. The cold compress gel has a physical cooling and heat dissipation effect.

The heat source part 2 is relatively fixed to the cold source part 1, and the relative spacing is set within five millimeters. The heat source part 2 is used to fit the heat source. The heat source part 2 includes a substrate 21, a wireless transmission module 22 and a control module 23. The wireless transmission module 22 is electrically connected to the control module 23 and both are arranged on the substrate 21. The wireless transmission module 22 is used to enable the control module 23 to communicate with the user end. A microfluidic channel is arranged on the substrate 21. In this embodiment, the bottom of the substrate 21 is used to contact the animal model, and the animal model is used as a heat source to form a temperature difference between the heat source part 2 and the cold source part 1. The substrate 21 can be made of PT material, which is the same as the cold source part 1. On the heat source part 2, since it is closer to the animal model, a microfluidic channel for drug administration is arranged on the heat source part 2. By connecting the microfluidic channel to a micro heat source pump or other devices, drug administration is performed. At the same time, the wireless transmission module 22 and the control module 23 arranged on the substrate 21 are integrated to greatly reduce the occupied space and improve portability.

The wireless transmission module 22 can send and receive information with the user end, thereby realizing information exchange between the control module 23 and the user. In particular, the user's control information can be converted into an electrical signal by the wireless transmission module 22 and then transmitted to the control module 23 for adjustment. The wireless communication of this embodiment is realized by the set wireless transmission module 22.

It should be noted that due to the limitation of the thickness of the heat source part 2, in order to avoid too slow entry efficiency of the drug solution, the number of microfluidic channels is preferably set to multiple, and liquid inlets corresponding to the microfluidic channels are set on the outer side of the substrate 21. The microfluidic channels are located at one end of the inner side of the substrate 21 and are interconnected to increase the entry efficiency of the drug solution by diversion. If a larger microfluidic channel is used for liquid entry, the opening may be too large to affect the mechanical stability of the substrate 21.

As shown in Figure 2, the thermoelectric interlayer 3 is arranged between the cold source part 1 and the heat source part 2, and is electrically connected to the wireless transmission module 22 and the control module 23. The thermoelectric interlayer 3 is used to cause carrier migration to form a voltage under the temperature difference between the cold source part 1 and the heat source part 2, so as to power the wireless transmission module 22 and the control module 23.

The thermoelectric interlayer 3 can be directly selected and set according to the Seebeck effect, which is also called the Seebeck effect, and is a thermoelectric effect. It describes the phenomenon that when the temperature of the two contact points in a closed loop composed of two different metals or semiconductors is different, a thermoelectric potential will appear in the loop and a current will flow through the loop. This effect allows a voltage difference to be generated between the two ends of the metal or semiconductor according to the temperature difference, which can be used to measure temperature or generate electrical energy in a thermoelectric power generation system. The principle of the Seebeck effect is based on the different movement speeds of electrons at different temperatures. When the temperature of the lower end increases, the electrons on that end will accelerate; conversely, when the temperature of the higher end decreases, the electrons will slow down. This temperature-dependent electron migration causes an imbalance in electron density, which leads to the generation of voltage.

By setting the thermoelectric interlayer 3 between the cold source part 1 and the heat source part 2, a certain voltage can be formed by the temperature difference between the cold source part 1 and the heat source part 2, and the wireless transmission module 22 and the control module 23 are powered by the formed voltage, thereby realizing passive driving in this embodiment.

The combination of wireless and passive technologies can provide powerful, durable and high-fidelity interfaces for the central and peripheral nervous systems. These interfaces and supporting platforms enhance the reproducibility of experiments, reduce the interaction between test subjects and environmental barriers, and reduce obstacles to social interaction in animal models.

The probe body 4 is fixed on the heat source part 2, and a drug administration channel is opened on the probe body 4. The drug administration channel is connected to the microfluidic channel and is used for local drug administration to the animal model. The probe body 4 includes a stimulation module 41, and the stimulation module 41 is electrically connected to the control module 23 for stimulating the local nerves of the animal model.

In a specific embodiment, the number of microfluidic channels is set to four, the probe body 4 is set in the middle position of the heat source part 2, and the drug delivery channel on the probe body 4 extends into the heat source part 2. The four microfluidic channels are all opened on the same side of the substrate 21, specifically on the thick side of the substrate 21, which can be conveniently connected to the external drug delivery pipeline. The microfluidic channels are all flat, and the four microfluidic channels are all bent toward the drug delivery channel in the substrate 21, and are interconnected at the ends of the drug delivery channel, so that the drug solution can enter the drug delivery channel together after being gathered inside the substrate 21.

The microfluidic channel includes channel one 211, channel two 212 and channel three 213. The four channels one 211 are parallel to each other and connected to the outside on the same side of the substrate 21. Channel two 212 is connected to channel one 211 and bent at the connection so that the extension direction of channel two 212 is toward the drug delivery channel. The four channels three 213 are connected to each other to form a collection channel, which brings the four microfluidic channels together and connects the drug delivery channel. The shortest straight line connecting the side where the opening side of channel one 211 is located with the center of the drug delivery channel on the substrate 21 is the middle line. The four microfluidic channels are mirror images of each other on both sides of the middle line. Channel one 211, channel two 212 and channel three 213 have the same thickness, and the width of channel 212 is consistent with the width of channel one 211.

The probe body 4 is a needle-shaped component. When it is used, one end is inserted into the body of the animal model, and the heat source part 2 connected to the other end of the probe body 4 is closely fitted with the animal model to achieve real-time heat exchange between the heat source part 2 and the animal model, so that the heat source part 2 and the cold source part 1 have a relatively stable temperature difference, and a voltage is formed through the thermoelectric interlayer 3 to power the control module 23, and the stimulation module 41 is formed into a stimulation source through the control module 23 to stimulate the nerves of the animal model, wherein the stimulation source can be at least one of an LED stimulation source, an electrical signal stimulation source or an ultrasonic stimulation source.

As shown in Figure 3, in this embodiment, in order to make the voltage formed by the temperature difference reach a certain value to drive the wireless transmission module 22 and the control module 23 to work, it can be achieved by increasing the ZT value of the thermoelectric interlayer 3. The ZT value is an important indicator for measuring the thermoelectric performance of thermoelectric materials. It reflects the maximum efficiency of energy conversion of thermoelectric materials at a specific temperature. Specifically, the thermoelectric interlayer 3 includes a silicon substrate 31, an alloy thin layer 32 and an interface 33. The two ends of the silicon substrate 31 are respectively fixed to the heat source part 2 and the cold source part 1, and the two ends of the alloy thin layer 32 are respectively fixed to the heat source part 2 and the cold source part 1. The alloy thin layer 32 is compositely fixed to the silicon substrate 31, and the interface 33 is composited between the silicon substrate 31 and the alloy thin layer 32. The interface 33 is used to enable heat conduction between the silicon substrate 31 and the alloy thin layer 32.

The alloy thin layer 32 is made of iron, vanadium, tungsten and aluminum, and its thickness can be set between 0.5-2 μm. Correspondingly, the thickness of the silicon substrate 31 is set between 0.2-0.4 mm, and the thickness of the interface 33 can be set between 10-30 nm. The interface 33 can be made of silicone grease or silica gel. Silicone grease is a commonly used insulating thermal conductive material with good thermal conductivity and insulation performance. It is suitable for filling the gap in the thermoelectric module to improve the thermal contact effect between the thermoelectric material and the heat sink, thereby improving the thermoelectric conversion efficiency. Silicone grease is a material with better thermal conductivity, which is usually used to fill the tiny gap in the thermoelectric module to improve the thermal contact effect between the thermoelectric material and the heat sink, and further improve the thermoelectric conversion efficiency. Selecting a suitable interface material is crucial to improving the performance of the thermoelectric module, which can effectively reduce thermal resistance and improve the thermoelectric conversion efficiency. In thermoelectric materials with higher ZT values, selecting a suitable interface material can further optimize the performance of the thermoelectric module.

In this embodiment, the thermoelectric interlayer 3 includes a positive terminal and a negative terminal, the positive terminal is fixed to the heat source part 2, and is electrically connected to the wireless transmission module 22 and the control module 23, and the negative terminal is fixed to the cold source part 1, and is electrically connected to the wireless transmission module 22 and the control module 23 to form a complete current loop. The positive terminal and the negative terminal of the thermoelectric interlayer 3 are not separate alloy films 32 or silicon substrates 31, but one end of the alloy film 32 and the silicon substrate 31 is composited as the positive terminal, and the other end is the negative terminal. The positive terminal and the negative terminal are not the structure or properties of the thermoelectric interlayer 3 itself, but when the thermoelectric interlayer 3 is in use, the end with a higher temperature is the positive terminal, and the end with a lower temperature is the negative terminal.

In order to enable the positive and negative ends of the thermoelectric interlayer 3 to be connected to the wireless transmission module 22 and the control module 23 for power supply, the heat source part 2 also includes a positive electrode sheet, which is arranged on the substrate 21, and the positive end of the thermoelectric interlayer 3 is electrically connected to the wireless transmission module 22 and the control module 23 through the positive electrode sheet. The cold source part 1 includes a negative electrode sheet, and the negative end of the thermoelectric interlayer 3 is electrically connected to the wireless transmission module 22 and the control module 23 through the negative electrode sheet. Through the set positive electrode sheet and negative electrode sheet, the thermoelectric interlayer 3 can be directly connected to the power supply end of the wireless transmission module 22 and the control module 23, thereby forming a complete circuit to power the wireless transmission module 22 and the control module 23, and the positive electrode sheet and the negative electrode sheet can be selected to be metal platinum.

As a preferred embodiment, the number of the thermoelectric interlayers 3 is multiple, and the array is arranged between the cold source part 1 and the heat source part 2, the positive end of each of the thermoelectric interlayers 3 is electrically connected to the positive electrode sheet, and the negative end of each of the thermoelectric interlayers 3 is electrically connected to the negative electrode sheet. By setting up multiple thermoelectric interlayers 3, the sum of the voltages of each thermoelectric interlayer 3 can form the power supply voltage of the wireless transmission module 22 and the control module 23 to meet the stable power supply requirements.

As a preferred embodiment, since the temperature difference may fluctuate greatly, resulting in the inability of the thermoelectric interlayer 3 to output a stable voltage, a voltage stabilizing module 24 is also provided on the heat source part 2, and the voltage stabilizing module 24 is provided on the substrate 21. The voltage stabilizing module 24 includes a voltage stabilizing input end and a voltage stabilizing output end, the voltage stabilizing input end is electrically connected to the thermoelectric interlayer 3, and the voltage stabilizing output end is electrically connected to the wireless transmission module 22 and the control module 23. The voltage stabilizing module 24 is used to stabilize the voltage formed on the thermoelectric interlayer 3 and output it to the wireless transmission module 22 and the control module 23.

Specifically, the voltage regulator module 24 includes a boost switching regulator and a Zener voltage divider regulator. The voltage regulator input end is located on the boost switching regulator, and the voltage regulator output end is located on the Zener voltage divider regulator. The boost switching regulator and the Zener voltage divider regulator are connected in series with each other. After the unstable voltage is input into the voltage regulator module 24, it is first boosted by the boost switching regulator and outputs a stable high voltage. The high voltage is then input into the series Zener voltage divider regulator, and is output after being stepped down and stabilized by the Zener shunt regulator, thereby obtaining a stable voltage that meets the system operation requirements.

In this embodiment, the control module 23 includes a microcontroller unit and a power regulating unit. The microcontroller unit is electrically connected to the wireless transmission module 22. The microcontroller unit is used to output a control signal. The power regulating unit has a control end, a power input end and a load end. The control end is electrically connected to the microcontroller unit. The control end is used to receive a control signal issued by the microcontroller unit. The power input end is electrically connected to the thermoelectric interlayer 3. The load end is electrically connected to the stimulation module 41. The power regulating unit is used to adjust the power of the stimulation module 41.

In a specific embodiment, in order to achieve wireless power adjustment, a digital potentiometer or an analog potentiometer can be connected to the analog input pin of the microcontroller for analog input control voltage. Connect a control pin of a power regulating chip such as LM317 to the digital output pin of the microcontroller for controlling power output. Connect the input pin of LM317 to the voltage regulating output end of the voltage regulating module 24, and the output pin is connected to the stimulation module 41. Then connect the wireless transmission module 22 to the microcontroller for wireless communication. The wireless transmission module 22 can use a wireless communication chip of model nRF24L01, and the microcontroller can use a controller of model ATtiny85. After the circuit connection is completed, the code of the microcontroller can be written, and the remote control signal is received through the wireless module, and the analog input control voltage is adjusted according to the signal, thereby controlling the output power of LM317. In this way, the control signal is sent through the wireless module, and the microcontroller can adjust the control voltage of the power regulating chip to realize the remote wireless power adjustment function. It should be noted that the specific circuit design and code writing need to be adjusted according to the specific microcontroller and wireless module model.

In this embodiment, the stimulation module 41 may optionally include at least one of an LED stimulation unit 411, an ultrasonic stimulation unit 412 and an electrical signal stimulation unit 413. The provided stimulation unit forms a stimulation source to stimulate the local nerves of the animal model.

As shown in FIG. 4 , in a specific embodiment, the stimulation module 41 includes three stimulation units: an LED stimulation unit 411 , an ultrasound stimulation unit 412 , and an electrical signal stimulation unit 413 .

Among them, the LED stimulation unit 411 is electrically connected to the thermoelectric interlayer 3, and the LED stimulation unit 411 is used to emit LED light to stimulate the local nerves of the animal model. The LED stimulation source formed by the LED stimulation unit 411 can use low-energy LED light to irradiate specific parts to stimulate the nervous system and promote nerve repair and regeneration. This method can be used to treat neurological diseases, nerve damage, pain, inflammation and other problems. LED nerve stimulation is considered to be a non-invasive, non-traumatic and side-effect-free treatment method. When used in animal models, it can alleviate its neurological symptoms and accelerate the recovery process. The LED stimulation unit 411 can directly use light-emitting diodes. At the same time, different wavelengths of light have different stimulating effects on the nervous system. It should be noted that red light with a wavelength of about 630-700 nanometers and near-infrared light with a wavelength of about 800-1000 nanometers have better stimulating effects on the nervous system.

The ultrasonic stimulation unit 412 is electrically connected to the thermoelectric interlayer 3, and is used to emit ultrasonic waves to stimulate the local nerves of the animal model, and achieves therapeutic effects by using ultrasonic waves to stimulate the nervous system. Ultrasonic stimulation is usually used for problems related to the nervous system such as nerve pain, neuroinflammation, and nerve damage. Ultrasonic nerve stimulation can help promote nerve regeneration and repair, relieve pain and inflammation, promote blood circulation, and accelerate the recovery process. The ultrasonic stimulation unit 412 can be directly selected as an ultrasonic transmitter. The frequency of the ultrasonic wave has an effect on the nerve stimulation effect. Generally speaking, ultrasonic waves with a frequency between 1MHz and 3MHz have a better stimulation effect on the nervous system.

The electrical signal stimulation unit 413 is electrically connected to the thermoelectric interlayer 3, and the electrical signal stimulation unit 413 is used to send electrical signals to stimulate the local nerves of the animal model, which stimulates nerve cells by transmitting electrical signals to the nervous system to achieve therapeutic effects. Electrical signal stimulation is usually used to treat problems related to the nervous system such as nerve pain, nerve damage, and muscle atrophy. Electrical signal nerve stimulation can help promote nerve regeneration and repair, relieve pain and inflammation, enhance muscle function, and promote the recovery process. The electrical signal stimulation unit 413 can directly select electrodes as electrical signal stimulation sources, and specifically carbon electrodes can be selected, which have better biocompatibility and can reduce patients' skin allergies or irritation reactions.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A wireless, powerless implantable probe based on thermoelectric materials, characterized by: comprises a cold source part (1), a heat source part (2), a thermoelectric interlayer (3) and a probe main body (4), wherein,

The cold source part (1) is used for attaching a cold source;

The heat source part (2) is fixed relative to the cold source part (1) and is used for attaching a heat source, the heat source part (2) comprises a substrate (21), a wireless transmission module (22) and a control module (23), the wireless transmission module (22) is electrically connected with the control module (23) and are arranged on the substrate (21), the wireless transmission module (22) is used for enabling the control module (23) to communicate with a user terminal, and a micro-flow channel is arranged on the substrate (21);

the thermoelectric interlayer (3) is arranged between the cold source part (1) and the heat source part (2) and is electrically connected with the wireless transmission module (22) and the control module (23), and the thermoelectric interlayer (3) is used for enabling carriers to migrate to form voltage under the temperature difference of the cold source part (1) and the heat source part (2) so as to supply power to the wireless transmission module (22) and the control module (23);

The probe main body (4) is fixed on the heat source part (2), a drug administration channel is formed in the probe main body (4), the drug administration channel is communicated with the microfluidic channel and used for locally administering drugs to the animal model, the probe main body (4) comprises a stimulation module (41), and the stimulation module (41) is electrically connected with the control module (23) and used for stimulating local nerves of the animal model.

2. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the thermoelectric interlayer (3) comprises a silicon substrate (31), a thin alloy layer (32) and an interface (33), wherein,

Both ends of the silicon substrate (31) are respectively fixed with the heat source part (2) and the cold source part (1);

Both ends of the alloy thin layer (32) are respectively fixed with the heat source part (2) and the cold source part (1), and the alloy thin layer (32) is compositely fixed with the silicon substrate (31);

an interface (33) is compounded between the silicon substrate (31) and the alloy thin layer (32), and the interface (33) is used for conducting heat between the silicon substrate (31) and the alloy thin layer (32).

3. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the thermoelectric interlayer (3) comprises a positive electrode end and a negative electrode end, wherein the positive electrode end is fixed with the heat source part (2) and is electrically connected with the wireless transmission module (22) and the control module (23), and the negative electrode end is fixed with the cold source part (1) and is electrically connected with the wireless transmission module (22) and the control module (23) so as to form a complete current loop.

4. A thermoelectric material based wireless, powerless implantable probe according to claim 3, wherein: the heat source part (2) further comprises a positive plate, the positive plate is arranged on the substrate (21), the positive end of the thermoelectric interlayer (3) is electrically connected with the wireless transmission module (22) and the control module (23) through the positive plate, the cold source part (1) comprises a negative plate, and the negative end of the thermoelectric interlayer (3) is electrically connected with the wireless transmission module (22) and the control module (23) through the negative plate respectively.

5. The thermoelectric material based wireless, powerless implantable probe of claim 4, wherein: the number of the thermoelectric interlayers (3) is multiple, the thermoelectric interlayers are arranged between the cold source part (1) and the heat source part (2) in an array manner, the positive ends of the thermoelectric interlayers (3) are electrically connected with the positive plates, and the negative ends of the thermoelectric interlayers (3) are electrically connected with the negative plates.

6. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the heat source part (2) further comprises a voltage stabilizing module (24), the voltage stabilizing module (24) is arranged on the substrate (21), the voltage stabilizing module (24) comprises a voltage stabilizing input end and a voltage stabilizing output end, the voltage stabilizing input end is electrically connected with the thermoelectric interlayer (3), the voltage stabilizing output end is electrically connected with the wireless transmission module (22) and the control module (23), and the voltage stabilizing module (24) is used for stabilizing the voltage formed on the thermoelectric interlayer (3) and then outputting the voltage to the wireless transmission module (22) and the control module (23).

7. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the control module (23) comprises a micro control unit and a power regulating unit, wherein,

The micro control unit is electrically connected with the wireless transmission module (22) and is used for outputting control signals;

The power regulating unit is provided with a control end, a power input end and a load end, wherein the control end is electrically connected with the micro-control unit, the control end is used for receiving a control signal sent by the micro-control unit, the power input end is electrically connected with the thermoelectric interlayer (3), the load end is electrically connected with the stimulation module (41), and the power regulating unit is used for regulating the power of the stimulation module (41).

8. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the stimulation module (41) comprises an LED stimulation unit (411), the LED stimulation unit (411) is electrically connected with the thermoelectric interlayer (3), and the LED stimulation unit (411) is used for emitting LED light to stimulate local nerves of the animal model.

9. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the stimulation module (41) comprises an ultrasonic stimulation unit (412), wherein the ultrasonic stimulation unit (412) is electrically connected with the thermoelectric interlayer (3), and the ultrasonic stimulation unit (412) is used for sending out ultrasonic waves to stimulate local nerves of the animal model.

10. The thermoelectric material based wireless, powerless implantable probe of claim 1, wherein: the stimulation module (41) comprises an electric signal stimulation unit (413), wherein the electric signal stimulation unit (413) is electrically connected with the thermoelectric interlayer (3), and the electric signal stimulation unit (413) is used for sending out electric signals to stimulate local nerves of the animal model.