CN117883507A - A Chinese medicine formula for indirectly reversing diabetes and its preparation method - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine formula for indirectly reversing diabetes, which is characterized by comprising the following raw materials: 5-30 parts of cassia twig, 5-30 parts of epimedium herb, 5-30 parts of morinda officinalis, 5-25 parts of dried orange peel and 3-15 parts of liquorice. In the invention, the traditional Chinese medicine formula can obviously relieve side effects caused by moderate hunger in the fasting process, improve the compliance of patients, and enable the patients to adhere to moderate hunger and reverse diabetes.

Description

A Chinese medicine formula for indirectly reversing diabetes and its preparation method

Technical Field

The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine formula for indirectly reversing diabetes.

Background technique

Modern pharmacological experiments and clinical trials have shown that moderate hunger can be used as a primary or auxiliary means to produce therapeutic effects on diabetes. In clinical practice, it is found that overweight and obese people often have "excess yin". After moderate hunger, they often experience cold limbs, no desire to drink water, fatigue, thick tongue coating, yellow and white complexion, and other symptoms of insufficient yang and phlegm and dampness. Therefore, it is urgent to solve the side effects of moderate hunger in diabetic patients to control their weight from the perspective of traditional Chinese medicine and Western medicine pharmacology.

Summary of the invention

The purpose of the present invention is to provide a Chinese medicine formula for indirectly reversing diabetes. The Chinese medicine formula has a significant alleviating effect on the side effects associated with moderate hunger, so that patients can persist in moderate hunger and reverse diabetes.

In order to achieve the above object, the technical solution of the present invention is as follows.

A Chinese medicine formula for indirectly reversing diabetes, characterized in that, measured by weight, the raw materials of the Chinese medicine formula include: 5-30 parts of cassia twig, 5-30 parts of epimedium, 5-30 parts of Morinda officinalis, 5-25 parts of tangerine peel, and 3-15 parts of liquorice.

"Insufficient Yang Qi and phlegm and turbidity" are the key pathological changes in the process of moderate hunger reversing diabetes, so "warming Yang and removing turbidity" is the key. Looking at the whole Chinese medicine formula, it is consistent with "those with phlegm and fluid should be treated with warm medicine" and the key pathological mechanism in the process of reversing diabetes.

Cinnamon twig is pungent in taste and warm in nature. It enters the heart, lung, and bladder meridians. It can warm the yang, transform qi and promote diuresis, and is the main medicine; Epimedium is pungent in taste and warm in nature. It enters the liver and kidney meridians. It can tonify the kidney and assist yang; Morinda officinalis is pungent in taste and slightly warm in nature. It enters the kidney meridian. It can tonify the kidney and assist yang, and eliminate dampness. They are all minister medicines; Tangerine peel is sweet in nature and warm in taste. It can strengthen the spleen, dry dampness and resolve phlegm. It is an adjuvant medicine; Licorice is sweet in taste and neutral in nature. It can tonify the spleen and replenish qi, relieve urgency and stop hunger, and can harmonize all medicines. It is the guiding medicine.

Furthermore, the Chinese medicine formula includes: 10 parts of cinnamon twig, 10 parts of epimedium, 10 parts of Morinda officinalis, 10 parts of tangerine peel, and 10 parts of liquorice.

Furthermore, the Chinese medicine formula includes: 5 parts of cinnamon twig, 5 parts of epimedium, 5 parts of Morinda officinalis, 10 parts of tangerine peel, and 10 parts of liquorice.

Furthermore, the cassia twig is stir-fried cassia twig, the epimedium is epimedium cordifolia, the Morinda officinalis is salt Morinda officinalis, the tangerine peel is tangerine peel, and the licorice is licorice root.

Furthermore, the Chinese medicine formula is in the form of powder, oral liquid, tablet, water pill, honey pill or capsule.

A method for preparing a traditional Chinese medicine for reversing diabetes, characterized in that the preparation method comprises:

Separate or combine the raw materials of the Chinese medicine formula and boil them twice with water;

Add 5-10 times the amount of water for the first time, boil for 1.5-3 hours, and collect the volatile oil;

Add 4-8 times the amount of water for the second time and boil for 0.5-1.5 hours;

The decoctions are combined, filtered, and the filtrate is placed at 60° C. and concentrated to form a concentrated solution with a specific gravity of 1.10-1.35;

The concentrate is diluted with water and allowed to stand for 24 hours, and the supernatant is filtered through a 300-400 mesh filter, concentrated again, and then made into powder, oral solution, tablets, water pills, honey pills or capsules.

In the present invention, the beneficial effect of the present invention is that it can significantly alleviate the side effects caused by moderate hunger during fasting, improve the compliance of patients, enable patients to adhere to moderate hunger, and reverse diabetes.

Detailed ways

In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

The present embodiment provides a first example of a traditional Chinese medicine formula for indirectly reversing diabetes. Calculated by weight, the traditional Chinese medicine formula includes: 10 parts of stir-fried cassia twigs, 10 parts of heart-leaf epimedium, 10 parts of salt-leaved Morinda officinalis, 10 parts of old tangerine peel, and 10 parts of inflated fruit liquorice.

In this embodiment, the Chinese medicine formula is in the form of powder, oral liquid, tablet, water pill, honey pill or capsule.

The present embodiment provides a second example of a traditional Chinese medicine formula for indirectly reversing diabetes. The traditional Chinese medicine formula includes, by weight: 5 parts of stir-fried cassia twig, 5 parts of heart-leaf epimedium, 5 parts of salt-leaved Morinda officinalis, 10 parts of old tangerine peel, and 10 parts of inflated fruit liquorice.

In this embodiment, the Chinese medicine formula is in the form of powder, oral liquid, tablet, water pill, honey pill or capsule.

This embodiment also provides a method for preparing a traditional Chinese medicine for reversing diabetes, the preparation method comprising:

Separate or combine the raw materials of the Chinese medicine formula and boil them twice with water;

Add 5-10 times the amount of water for the first time, boil for 1.5-3 hours, and collect the volatile oil;

Add 4-8 times the amount of water for the second time and boil for 0.5-1.5 hours;

The decoctions are combined, filtered, and the filtrate is placed at 60° C. and concentrated to form a concentrated solution with a specific gravity of 1.10-1.35;

The concentrate was diluted with water and allowed to stand for 24 hours, and the supernatant was filtered through a 300-400 mesh filter and concentrated again;

Then add appropriate amount of excipients, spray dry into granules, and pack into small bags to obtain powder; or make into oral liquid, tablets, water pills, honey pills or capsules according to conventional preparation technology.

When this Chinese medicine formula was used to treat patients with type 2 diabetes, 34 patients who were moderately hungry for 7 days were clinically observed, all of whom were type 2 diabetes patients; all 34 patients persisted in moderate hunger and reversed diabetes, and the clinical efficacy of all patients was evaluated and followed up for 6 months; after taking this preparation during the moderate hunger period, symptoms such as hunger, chills and cold limbs, fatigue, dizziness and stuffiness were significantly reduced, and glycosylated hemoglobin was significantly reduced after fasting, 3 months of follow-up, and 6 months of follow-up; the results showed that this drug has a significant alleviating effect on the side effects associated with moderate hunger, allowing patients to persist in moderate hunger, reverse diabetes, and lose weight, and no hypoglycemia or other adverse reactions were observed during use.

Clinical observations of the Chinese medicine formula in treatment:

(I) Diagnostic criteria for type 2 diabetes: Diagnosis of type 2 diabetes (for diagnostic criteria, see the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2017 Edition)); BMI ≥ 24 kg/m2.

(II) Case inclusion criteria

1. Aged 18 to 65;

2. Meet the criteria for type 2 diabetes;

3. Meet the criteria: BMI ≥ 24 kg/m2;

4. Normal heart, liver and kidney functions;

5. Comply with the Declaration of Helsinki and sign the informed consent;

(III) Case exclusion criteria

1. Those who have used insulin therapy;

2. Recent glycosylated hemoglobin ≥ 12%;

3. Pregnant or lactating women;

4. Malignant tumor or blood disease;

5. Mental illness;

6. Ulcers with severe gastric bleeding;

7. Excessive weight loss and malnutrition;

8. Patients with serious concurrent diseases;

9. Those who used drugs or surgery to lose weight within 3 months;

10. Unable to cooperate with treatment and poor compliance;

11. Other situations that the researcher judges to be unsuitable for enrollment.

(IV) Treatment methods

All patients signed an informed consent form before starting treatment. In the first month of moderate hunger, they took one dose of Chinese medicine every day, decocted it in water twice, and extracted about 1000 ml of juice. They drank it in small amounts frequently when they felt hungry between 10-12 am and 3-6 pm.

(V) Observation indicators

Changes in indicators such as glycated hemoglobin before, 3 months, and 6 months of moderate starvation.

(VI) Results Comparison of glycosylated hemoglobin (%) before and after fasting and during follow-up

The drug of the present invention was clinically used for 34 patients with type 2 diabetes and was effective.

VII. Conclusion

The drug of the present invention combined with fasting has a good therapeutic effect on metabolic syndrome without obvious adverse reactions; it can greatly improve the patient's ability to tolerate hunger and compliance with dietary control.

The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims (6)

1. A Chinese medicine formula for indirectly reversing diabetes, characterized in that, measured by mass, the raw materials of the Chinese medicine formula include: 5-30 parts of cassia twig, 5-30 parts of epimedium, 5-30 parts of Morinda officinalis, 5-25 parts of tangerine peel, and 3-15 parts of liquorice. 2. The Chinese medicine formula for indirectly reversing diabetes according to claim 1, characterized in that the Chinese medicine formula comprises: 10 parts of cinnamon twig, 10 parts of epimedium, 10 parts of Morinda officinalis, 10 parts of tangerine peel, and 10 parts of liquorice. 3. The Chinese medicine formula for indirectly reversing diabetes according to claim 1, characterized in that the Chinese medicine formula comprises: 5 parts of cinnamon twig, 5 parts of epimedium, 5 parts of Morinda officinalis, 10 parts of tangerine peel, and 10 parts of liquorice. 4. A Chinese medicine formula for indirectly reversing diabetes according to claim 1, characterized in that the cinnamon twig is stir-fried cinnamon twig, the epimedium is epimedium cordifolia, the Morinda officinalis is salt Morinda officinalis, the tangerine peel is tangerine peel, and the licorice is licorice root. 5. A Chinese medicine formula for indirectly reversing diabetes according to any one of claims 1-4, characterized in that the Chinese medicine formula is in the form of powder, oral liquid, tablet, water pill, honey pill or capsule. 6. A method for preparing a traditional Chinese medicine for reversing diabetes, characterized in that the preparation method comprises: Separate or combine the raw materials of the Chinese medicine formula according to any one of claims 1 to 5 and boil them twice with water; Add 5-10 times the amount of water for the first time, boil for 1.5-3 hours, and collect the volatile oil; Add 4-8 times the amount of water for the second time and boil for 0.5-1.5 hours; The decoctions are combined, filtered, and the filtrate is placed at 60° C. and concentrated to form a concentrated solution with a specific gravity of 1.10-1.35; The concentrate is diluted with water and allowed to stand for 24 hours, and the supernatant is filtered through a 300-400 mesh filter, concentrated again, and then made into powder, oral solution, tablets, water pills, honey pills or capsules.