CN117815525A - Prefilled nasal spray device with sealing switch - Google Patents

Abstract

The pre-filled and sealed nasal spray device comprises a syringe, a nasal spray head and a fixing seat, wherein the fixing seat is arranged on the syringe, the nasal spray head is connected with the fixing seat, and a liquid channel from an inner cavity of the syringe to the nasal spray head through the fixing seat is formed in the pre-filled and sealed nasal spray device. A sealing switch is arranged in the liquid channel, the sealing switch being switchable between an open state in which the interior cavity of the syringe is in communication with the outside via the liquid channel and a closed state in which the interior cavity of the syringe is sealed from the outside. In the pre-filling and sealing nasal spray device, the sealing switch is simple in structure, and reliable sealing can be realized on liquid medicine pre-filled and sealed in the pre-filling and sealing nasal spray device.

Description

Prefilled nasal spray device with sealing switch

Technical Field

The present application relates to medical devices, and in particular to a nasal spray device for applying a medicament to an internal cavity of a human body such as a nasal cavity, and in particular, the nasal spray device is a pre-filled nasal spray device.

Background

There are various different types of spray delivery devices on the market, including a pre-filled nasal spray device. The prefilled nasal spray device is characterized in that the liquid medicine is prefilled into a needle cylinder of the spray administration device. In this way, when the medicine is applied to the nasal cavity or the like of the user, the medicine in the syringe can be directly injected into the nasal cavity without sucking the medicine liquid from the medicine container such as a penicillin bottle. The pre-filled nasal spray device is convenient to use, so that the application occasions of the pre-filled nasal spray device are wider and wider.

Since the liquid medicine to be applied to the user is pre-filled in the pre-filled nasal spray device, the sealing requirement for the pre-filled nasal spray device is particularly high to ensure the quality of the liquid medicine contained in the pre-filled nasal spray device.

In other words, the sealing properties of the pre-filled nasal spray device are critical to the quality of the medical fluid contained therein. If the sealing performance of the pre-filled nasal spray device is poor, on the one hand, the liquid medicine filled in the device can leak, volatilize and the like, so that the dosage which can be applied to a user is reduced, on the other hand, the liquid medicine can be contacted with the external environment, and the liquid medicine is polluted, oxidized and the like, so that the liquid medicine is deteriorated. The dosage reduction can influence the curative effect of the medicine, and the situations of medicine liquid pollution, oxidization and the like can influence the curative effect, and hidden danger can be buried on the use safety of the medicine.

Therefore, strict control is required during the design and production of the pre-filled nasal spray device to maximize its sealing performance with the highest answer standards.

The sealing structure of the existing pre-filling and sealing nasal spray device usually adopts a protective cap type sealing, namely, a protective cap is additionally arranged on the pre-filling and sealing nasal spray device so as to isolate the interior of the pre-filling and sealing nasal spray device from the outside. Common helmets are, for example, bayonet helmets, luer helmets, and the like. A disadvantage of bayonet-type helmets is that they do not seal reliably and are prone to slipping off the pre-filled nasal spray device, resulting in seal failure. The installation of luer caps requires a high level of expertise and requires a person of great practical experience to do so, either by screwing too loosely or by screwing too tightly. If too loosely screwed, the required seal is not achieved, but if too tightly screwed, the luer connection between the cap and the pre-filled nasal spray device is again prone to slipping off.

There is therefore a need for a prefilled nasal spray device whose structure is further improved, which can achieve reliable sealing on the prefilled nasal spray device with a simple structure.

Disclosure of Invention

The present application has been made to solve the above-mentioned problems occurring in the prior art. The object of the present application is to provide a pre-filled nasal spray device with an improved structure, comprising a sealing switch of simple structure, capable of achieving a reliable seal for the pre-filled nasal spray device.

The application provides a device is spouted to embedment nose in advance, this device is spouted to embedment nose in advance has syringe, nose shower nozzle and fixing base, and the fixing base is installed on the syringe, and the nose shower nozzle is connected in the fixing base, wherein, is formed with the liquid channel from the inside cavity of syringe to the nose shower nozzle through the fixing base in the device is spouted to embedment nose in advance. A sealing switch is arranged in the liquid channel, the sealing switch being switchable between an open state in which the interior cavity of the syringe is in communication with the outside via the liquid channel and a closed state in which the interior cavity of the syringe is sealed from the outside.

In the pre-filling and sealing nasal spray device, the sealing switch is simple in structure, and reliable sealing can be realized on pre-filled and sealed liquid medicine in the pre-filling and sealing nasal spray device.

In a specific structure, the sealing switch comprises a sealing plug, a sealing surface is formed at the front end of the fixing seat or on a needle seat of the injector, and the sealing plug can form sealing fit with the sealing surface.

Further specifically, the nose cup is movable relative to the holder in an axial direction of the pre-filled nasal spray device between a closed position in which the nose cup presses the sealing plug against the sealing surface and an open position in which the nose cup releases the pressing against the sealing plug.

Preferably, the fixing base comprises a guide rail part, and the top surface of the guide rail part comprises a lowering surface and a lifting surface; at least one slide block is formed on the outer surface of the outer sleeve of the nose nozzle, and the slide block is placed on the top surface of the guide rail part. The nose cup is rotatable relative to the mounting base such that the slider is in contact with the lowering surface and the raising surface, respectively, the nose cup being in a closed position relative to the mounting base when the slider is in contact with the lowering surface and in an open position relative to the mounting base when the slider is in contact with the raising surface.

In such a structure, the sealing switch can be easily opened and closed by rotating the nose cup with respect to the fixed base.

Alternatively, in another configuration, the nasal spray head is configured to be linearly movable relative to the mounting base along an axial direction of the pre-filled nasal spray device between a closed position and an open position.

Preferably, the sealing surface is a tapered inner surface formed in the front end of the holder or in the hub of the syringe. The tapered inner surface helps to improve the mating tightness between the sealing plug and the sealing surface.

In another specific construction, the sealing switch includes an aperture, the sealing switch being movable between a closed position in which the aperture is closed and an open position in which the aperture is open.

One exemplary embodiment of the opening is at least one side hole formed at the front end of the holder.

Preferably, the nose includes a nose inner sleeve having an inner diameter set smaller than an outer diameter of a portion of a front end of the fixing base where the side hole is formed, such that the portion of the front end where the side hole is formed is interference-fitted with the nose inner sleeve, and at least one guide groove is formed in the nose inner sleeve. Wherein the nose cup is rotatable relative to the holder between a closed position in which the side aperture is offset from the channel and an open position in which the side aperture is aligned with the channel.

Further preferably, the nose head includes a nose head inner sleeve in which a large inner diameter portion and a small inner diameter portion are formed, the inner diameter of the small inner diameter portion being smaller than the outer diameter of the portion of the front end of the fixing base where the side hole is formed, so that the portion of the front end of the fixing base where the side hole is formed forms an interference fit with the small inner diameter portion, and the inner diameter of the large inner diameter portion being larger than the outer diameter of the portion of the front end of the fixing base where the side hole is formed. Wherein the nasal spray head is capable of linear movement in an axial direction of the pre-potting head relative to the holder between a closed position in which a portion of the front end of the holder where the side aperture is formed is in interference fit with the small inner diameter portion and an open position in which the portion of the front end of the holder where the side aperture is formed is in the large inner diameter portion.

Further preferably, a groove is formed in the nose cup and a peripheral flange is formed on the holder, the peripheral flange fitting into the groove when the nose cup is connected to the holder, wherein the width of the groove is greater than the width of the peripheral flange, thereby allowing linear movement of the nose cup relative to the holder.

In another embodiment, the sealed switch includes a knob including a stem, the opening being a through hole formed in the stem. The fixing seat is internally provided with a transverse hole, the transverse hole extends along the direction vertical to the axial direction of the pre-filling and sealing nasal spray device, and the rod part is inserted into the transverse hole of the fixing seat. Wherein the knob is rotatable between a closed position in which the through-hole is offset from the longitudinal passage of the holder and an open position in which the through-hole is aligned with the longitudinal passage.

By rotating the knob, the sealing switch can be easily opened and closed.

Preferably, the nose nozzle or the fixing seat is integrally formed or connected with a finger buckle plate.

Further preferably, a stop catch is provided between the thumbplate and the flange on the rear end of the syringe. The stop catch can prevent the syringe from moving forward relative to the holder or nose cup during storage and transportation.

Alternatively, at least one frangible member may be provided between the thumbplate and the flange on the rear end of the syringe. In use, the breakable member can be broken by pushing the syringe forward, thereby allowing the syringe to move forward.

Drawings

Embodiments of the present invention will be more clearly understood from the structure shown in the accompanying drawings, in which:

fig. 1 shows a cross-sectional view of a pre-filled nasal spray device of a first embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

Fig. 2 shows another cross-sectional view of the prefilled nasal spray device of the first embodiment, wherein the prefilled nasal spray device is in an open state.

Fig. 3a is a partial enlarged view of a portion A1 in fig. 1.

Fig. 3B is a partial enlarged view of a portion B1 in fig. 2.

Fig. 4a shows a perspective view of the nasal spray head of the pre-filled nasal spray device of fig. 1.

Fig. 4b shows a perspective view of the holder of the pre-filled nasal spray device of fig. 1, without the finger tabs.

Fig. 4c shows a perspective view of the nose cup of fig. 4a assembled with the anchor mount of fig. 4 b.

Fig. 5 shows a cross-sectional view of a seal plunger in the pre-filled nasal spray device of fig. 1.

Fig. 6 shows a cross-sectional view of another construction of the holder with the finger tabs.

Fig. 7 shows a cross-sectional view of a pre-filled nasal spray device of a second embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

Fig. 8 shows another cross-sectional view of the pre-filled nasal spray device of the second embodiment, wherein the pre-filled nasal spray device is in an open state.

Fig. 9a is a partial enlarged view of a portion A2 in fig. 7.

Fig. 9B is a partial enlarged view of a portion B2 in fig. 8.

Fig. 10 shows a cross-sectional view of a pre-filled nasal spray device of a third embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

Fig. 11 shows another cross-sectional view of the pre-filled nasal spray device of the third embodiment, wherein the pre-filled nasal spray device is in an open state.

Fig. 12a is a partial enlarged view of a portion A3 in fig. 10.

Fig. 12B is a partial enlarged view of a portion B3 in fig. 11.

Fig. 13 shows a cross-sectional view of a pre-filled nasal spray device of a fourth embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

Fig. 14 shows another cross-sectional view of the pre-filled nasal spray device of the fourth embodiment, wherein the pre-filled nasal spray device is in an open state.

Fig. 15a is a partial enlarged view of a portion A4 in fig. 13.

Fig. 15B is a partial enlarged view of a portion B4 in fig. 14.

Fig. 16 shows a cross-sectional view of a pre-filled nasal spray device of a fifth embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

Fig. 17 shows another cross-sectional view of the pre-filled nasal spray device of the fifth embodiment, wherein the pre-filled nasal spray device is in an open state.

Fig. 18a is a partial enlarged view of a portion A5 in fig. 16.

Fig. 18B is a partial enlarged view of a portion B5 in fig. 17.

(symbol description)

100 prefilled nose spraying device

110 injector

111 needle stand

120 nose nozzle

121 nose nozzle outer sleeve

122 slider

123 limiting block

130 fixing seat

131 guide rail part

132 lowering the surface

133 raise surface

134 conical inner surface

135 liquid outlet

136 finger buckle plate

140 sealing plug

141 conical outer surface

200 prefilled nose spraying device

210 injector

220 nose spray head

221 nose nozzle inner sleeve

222 diversion trench

230 fixing seat

231 side hole

300 prefilled nose spraying device

310 injector

320 nose spray head

321 nose nozzle inner sleeve

322 large inner diameter portion

323 small inner diameter part

324 groove

325 finger buckle plate

330 fixing seat

331 side hole

332 peripheral flange

350 stop clip

400 prefilled nose spraying device

410 injector

420 nose nozzle

421 nose nozzle inner sleeve

422 groove

430 fixing seat

431 convex ring

440 sealing plug

500 prefilled nose spraying device

510 injector

520 nose nozzle

521 side opening

530 fixing seat

531 cross holes

532 longitudinal channels

540 knob

541 pole section

542 through hole

543 convex ring

Detailed Description

In order to facilitate an understanding of the present invention, a detailed description of specific embodiments of the pre-filled nasal spray device of the present invention will be provided below with reference to the accompanying drawings. It is to be understood that the drawings illustrate only the preferred embodiments of the invention and are not to be considered limiting of the scope of the invention. Various obvious modifications, variations, equivalent substitutions of the invention will be apparent to those skilled in the art based on the embodiments shown in the drawings, and the technical features of the different embodiments described below can be arbitrarily combined with each other without contradiction, and these fall within the scope of the invention.

In the following description of the pre-filled nasal spray device, terms such as "front", "rear", "upper", "lower" and the like are used to denote directions based on the orientation of the pre-filled nasal spray device shown in the drawings, and the orientation of the pre-filled nasal spray device shown in the drawings refers to the orientation that the pre-filled nasal spray device takes in use, wherein "front", "upper" refers to the upper side or end in the drawings that corresponds to the side or end of the pre-filled nasal spray device that is adjacent to the person to be administered with the medicament, and "rear", "lower" refers to the lower side or end in the drawings that corresponds to the side or end of the pre-filled nasal spray device that is remote from the person to be administered with the medicament.

< first embodiment >

Fig. 1 to 6 show the structure of a pre-potting nose spraying apparatus 100 and its respective components according to a first embodiment of the present application.

The pre-filled nasal spray device 100 includes a syringe 110, a nasal spray head 120, and a mount 130. The nose cup 120 is relatively movably coupled to the mounting 130, the specific coupling structure of which will be described in more detail below. The holder 130 is then secured to the hub 111 of the pre-filled nasal spray device 100 at the forward end of the syringe 110 by a structure such as a snap fit. Here, the syringe 110 may be a glass syringe or a plastic syringe, which is within the scope of the present application.

As shown, a fluid passage from the inner cavity of the syringe 110 to the inner cavity of the nasal spray head 120 through the fixing base 130 is formed in the pre-filled nasal spray device 100, and the medical fluid pre-filled in the syringe 110 can flow to the nozzle of the nasal spray head 120 through the fluid passage and be sprayed out.

Fig. 4a shows a schematic perspective view of the nasal spray head 120 of the pre-filled nasal spray device 100. The exemplary nose jet 120 shown in the figures is of a three-way construction to which two nozzles may be connected. However, it is within the scope of this application that the nose cup 120 may be provided in a single-head configuration, including only one nozzle thereon, as will be appreciated by those skilled in the art.

The nose cup 120 has a nose cup outer sleeve 121 with at least one slider 122 formed on an outer surface of the nose cup outer sleeve 121. Preferably, two sliders 122 are formed on the outer surface of the nose cup outer sleeve 121, which are disposed 180 ° apart from each other. At least one stopper 123 is preferably further formed on the outer surface of the outer nose nozzle sleeve 121 of the nose nozzle 120, and the stopper 123 is engaged with a guide rail portion 131 of a fixing seat 130 to be described later, to achieve a relatively movable connection between the nose nozzle 120 and the fixing seat 130.

Fig. 4b shows a schematic perspective view of the holder 130 of the pre-filled nasal spray device 100. The fixing base 130 includes a guide rail portion 131 provided on an outer circumference thereof, the guide rail portion 131 having a guide surface on a top thereof, the guide surface including a lowering surface 132 and a raising surface 133.

Fig. 4c shows a perspective view of the assembled nose cup 120 and mounting 130. When assembled together, the slider 122 on the nose cup 120 rests on the guide surface of the rail portion 131. The limiting block 123 is located below the guide rail 131, and cooperates with the lower surface of the guide rail 131 to prevent the nose nozzle 120 from being separated from the fixing base 130.

With further reference to fig. 6, it can be seen that a tapered inner surface 134 is formed at the front end of the holder 130, the tapered inner surface 134 being adjacent to the outlet 135 of the holder 130, the outlet 135 being in communication with the bore in the hub 111 of the syringe 110 in the installed state. The lower end of the sealing plug 140 (see fig. 5) may sealingly engage the tapered inner surface 134 to block the fluid outlet 135 and thereby prevent leakage of the medical fluid pre-filled in the syringe 110 or contact with the external environment. It can be seen that the sealing plug 140 cooperates with the tapered inner surface 134 in the holder 130 to form a sealing switch, and the sealing switch is disposed in the fluid passage.

Preferably, in the structure shown in fig. 5, a tapered outer surface 141 is formed at the lower end of the sealing plug 140, the tapered outer surface 141 being shaped to match the tapered inner surface 134 within the holder 130. In this way, when the sealing plug 140 is sealingly engaged against the tapered inner surface 134, a face seal is formed between the sealing plug 140 and the mount 130, thereby enabling a more reliable seal to be formed.

Further, as shown in fig. 6, a finger plate 136 is preferably further disposed on the fixing base 130, and the finger plate 136 is integrally formed at a lower end (or rear end) of the fixing base 130, for example. Of course, the finger plate 136 may be formed at other suitable locations on the mounting base 130. Alternatively, the finger plate 136 may be formed separately and then attached to the anchor 130 in place.

Returning to fig. 1 and 2, and in conjunction with fig. 3a and 3b, the principle of operation of the pre-filled nasal spray device 100 of the first embodiment will be described.

The pre-filled nasal spray device 100 shown in fig. 1 is in a closed state, in which the pre-filled nasal spray device 100 may be stored and transported or the like. At this time, the slider 122 of the nose head 120 is engaged with the lowered surface 132 in the guide surface of the guide rail portion 131 of the holder 130. At this time, the sealing plug 140 is compressed in the space between the inner nasal spray sleeve 124 of the nasal spray 120 and the upper end of the fixing base 130, and the lower end of the sealing plug 140, for example, the tapered outer surface 141 thereof is compressed on the tapered inner surface 134, thereby forming a seal, isolating the medical fluid pre-filled in the syringe 110 from the external environment (see fig. 3 a).

When it is desired to apply a medical fluid to a user, an operator (e.g., a medical practitioner) rotates the nasal spray 120 relative to the mount 130 such that the slider 122 of the nasal spray 120 slides on the rail portion 131 of the mount 130 from the lowered surface 132 to the raised surface 133, thereby axially moving the nasal spray 120 away from the injector 110. In this way, the axial pressing force applied to the sealing plug 140 is released, thereby achieving the open state shown in fig. 2. At this time, the operator pushes the plunger 112 of the syringe 110, and the sealing plug 140 is pushed away from the tapered inner surface 134 by the pressure of the medical fluid, so that the sealing switch is opened (see fig. 3 b), and the medical fluid in the syringe 110 can enter the nasal spray 120 and be sprayed out through the nozzle on the nasal spray 120 and be applied to the user, for example, to the nasal cavity thereof.

< second embodiment >

Fig. 7-9 b show a pre-filled nasal spray device 200 according to a second embodiment of the present application. The specific structure described above with respect to the first embodiment is also applicable to the second embodiment without contrary description or conflict. In the following description, the same structure will not be described in detail, and the structure of the second embodiment different from that of the first embodiment will be described in detail.

Similar to the first embodiment, the pre-filled nasal spray device 200 includes a syringe 210, a nasal spray 220, and a holder 230. The holder 230 is coupled to the hub of the syringe 210 by a snap-fit or the like. The nose cup 220 and the holder 230 may also be coupled together by a snap-fit or the like, and the nose cup 220 may be rotatable relative to the holder 230.

Fig. 7 shows the pre-filled nasal spray device 200 in a closed state. Referring to fig. 9a, the front end of the holder 230 is formed with at least one side hole 231. In the exemplary configuration shown in the figures, two side holes 231 are included, which are arranged 180 ° apart from each other. The forward end of the holder 230 is an interference fit in the inner nose cup sleeve 221 of the nose cup 220. In this way, the inner surface of the inner nasal spray sleeve 221 is in sealing contact with the outer surface of the front end of the holder 230, particularly the portion thereof including the side aperture 231, such that the side aperture 231 is in a closed state.

Fig. 8 shows the pre-filled nasal spray device 200 in an open state. Compared to the closed state shown in fig. 7, the nose 220 is rotated by a preset angle, for example, by 180 ° with respect to the holder 230. Referring to fig. 9b, at least one flow guide groove 222 is provided on the inner surface of the inner sleeve 221 of the nasal spray head, for example, in the structure shown in the drawing, two flow guide grooves 222 are provided at 180 ° from each other. At this time, after rotating through a preset angle, the guide groove 222 in the nasal spray head 220 is aligned with the side hole 231 in the fixing base 230, thereby opening the side hole 231, and the sealing of the pre-filled nasal spray device 200 is released.

It can be seen that in the second embodiment, the inner surface of the inner sleeve 221 of the nasal spray head cooperates with the side hole 231 of the fixing base 230 to form a sealed switch of the pre-filled nasal spray device 200.

< third embodiment >

Fig. 10-12 b show a pre-filled nasal spray device 300 according to a third embodiment of the present application. The specific structures described above with respect to the first and second embodiments are also applicable to the third embodiment without contrary description or conflict. In the following description, the same structure will not be described in detail, and the structure of the third embodiment different from the first and second embodiments will be specifically described.

Similar to the previous embodiments, the pre-filled nasal spray device 300 includes a syringe 310, a nasal spray 320, and a mount 330. The holder 330 is coupled to the hub of the syringe 310 by a snap-fit or the like. The nasal spray head 320 is coupled to the holder 330 and is capable of rectilinear motion relative to the holder 330 in the axial direction of the pre-filled nasal spray device 300.

Fig. 10 shows the prefilled nasal spray device 300 in a closed position. With further reference to fig. 12a, it can be seen that the front end of the holder 330 is formed with at least one side hole 331. The inner surface of the inner nose cup sleeve 321 of the nose cup 320 is formed in a stepped shape so that a large inner diameter portion 322 having a large inner diameter and a small inner diameter portion 323 having a small inner diameter are formed inside the inner nose cup sleeve 321. Wherein the large inner diameter portion 322 is located in front of the small inner diameter portion 323.

The inner diameter of the small inner diameter portion 323 is set to be slightly smaller than the outer diameter of the front end of the holder 330, so that the front end of the holder 330 can be interference-fitted with the small inner diameter portion 323. Thus, when the front end of the holder 330 is fitted in the small inner diameter portion 323, the side hole 331 may be sealed closed (fig. 12 a).

The inner diameter of the large inner diameter portion 322 is set to be larger than the outer diameter of the front end of the holder 330. Thus, when the front end of the holder 330 is fitted in the large inner diameter portion 322, a gap exists between the front end of the holder 330 and the large inner diameter portion 322, so that the side hole 331 is opened (fig. 12 b). Thus, the chemical solution prefilled in the syringe 310 can be introduced into the nozzle from the side hole 331 and ejected.

Preferably, the inner nasal spray sleeve 321 has a recess 324 formed therein and a peripheral flange 332 formed on the anchor 330. The peripheral flange 332 is capable of fitting into the recess 324 when the nose cup 320 is assembled with the anchor block 330. Also, the width of the peripheral flange 332 is less than the width of the groove 324, thereby allowing the nose cup 320 to reciprocate axially relative to the mount 330.

Preferably, a finger 325 is also formed on the nose cup 320, and the finger 325 may be integrally formed on the nose cup 320 or may be separately formed and connected to the nose cup 320.

Further preferably, the pre-filled nasal spray device 300 further includes a stop clip 350. In the closed state of the pre-filled nasal spray device 300 shown in fig. 10, the stop catch 350 is captured between the finger tabs 325 of the nasal spray 320 and the flange on the rear end of the syringe 310 to prevent movement of the syringe 310 toward the front end relative to the nasal spray 320.

When the operator applies the medical fluid to the user, the operator removes the stopper 350. Then, the plunger of the syringe 310 may be pushed toward the front end, and the syringe 310 and the holder 330 coupled to the needle mount thereof are pushed forward by the pressure of the medical fluid in the syringe 310, so that the portion of the front end of the holder 330 including the syringe 310 moves into the large inner diameter portion 322 of the syringe 310, thereby opening the side hole 331.

In addition to the stop catch 350, other structures may be provided to prevent relative forward movement of the syringe 310 during storage and transportation. One possible alternative is to provide a frangible member between thumb plate 325 and the rear end flange of syringe 310, such as a spacer ring with a frangible portion connected between thumb plate 325 and the rear end flange of syringe 310. In use, an operator pushes the plunger of the syringe 310 in the direction of the front end, which in turn pushes the syringe 310 towards the front end, under the action of which the spacer ring breaks or breaks along the frangible portion, thereby allowing the syringe 310 to move forward.

Further, the frangible member may also be a plurality of frangible struts circumferentially arranged, connected between the finger tabs 325 and the rear end flange of the syringe 310.

The frangible member may be integrally formed on one of the thumbclip 325 and the rear end flange of the syringe 310. Alternatively, the frangible member can be formed separately and connected between the thumbtack plate 325 and the rear flange of the syringe 310.

It can be seen that the side holes 331 in the holder 330 cooperate with the large inner diameter 322 and the small inner diameter 323 of the inner surface of the inner nose cap sleeve 321 of the nose cap 320 to form a sealed switch.

< fourth embodiment >

Fig. 13-15 b show a pre-filled nasal spray device 400 according to a fourth embodiment of the present application. The specific structures described above with respect to the first to third embodiments are also applicable to the fourth embodiment without contrary description or conflict. In the following description, the same structure will not be described in detail, and the structure of the fourth embodiment different from the first to third embodiments will be described in detail.

In a fourth embodiment, the pre-filled nasal spray device 400 includes a syringe 410, a nasal spray head 420, and a holder 430. The holder 430 is coupled to the hub of the syringe 410 by a snap-fit or the like. The nasal spray head 420 is coupled to the mounting base 430 and is capable of axial movement of the pre-potted nasal spray device 400 relative to the mounting base 430. Specifically, as shown in fig. 13, a collar 431 is formed on an outer surface of the holder 430, a groove 422 is formed on an inner surface of the outer sleeve of the nasal spray head 420, the collar 431 is fitted in the groove 422, and the fit between the collar 431 and the groove 422 allows relative movement between the nasal spray head 420 and the holder 430 in an axial direction of the pre-potting nasal spray device 400.

The pre-filled nasal spray device 400 further includes a sealing plug 440, which sealing plug 440 is located in a space in the front end of the holder 430 and is insertable into a liquid outlet on the hub of the syringe 410. As shown in fig. 15a, when the pre-filled nasal spray device 400 is in the closed state shown in fig. 13, the nasal spray head 420 is in a rearward position relative to the holder 430, wherein the inner nasal spray head sleeve 421 of the nasal spray head 420 presses against the sealing plug 440, such that the sealing plug 440 remains inserted into the outlet of the needle mount of the syringe 410.

In use, an operator pulls the nose cup 420 forward relative to the holder 430 (see arrow in fig. 14), thereby releasing the pressure of the nose cup inner sleeve 421 of the nose cup 420 against the sealing plug 440 (see fig. 15 b). The plunger of the syringe 410 is then pushed, and the sealing stopper 440 is pushed open by the hydraulic force of the medicine in the syringe 410, so that the medicine can be applied outward.

It can be seen that in the fourth embodiment, the sealing plug 440 cooperates with the inner nose cup sleeve 421 of the nose cup 420 to function as a sealing switch.

< fifth embodiment >

Fig. 16-18 b show a pre-filled nasal spray device 500 according to a fifth embodiment of the present application. The specific structures described above with respect to the first to fourth embodiments are also applicable to the fifth embodiment without contrary description or conflict. In the following description, the same structure will not be described in detail, and the structures of the fifth embodiment different from those of the first to fourth embodiments will be specifically described.

In a fifth embodiment, the pre-filled nasal spray device 500 includes a syringe 510, a nasal spray 520, and a holder 530. The fixed seat 530 is connected to the needle seat of the syringe 510, and the nose nozzle 520 is connected to the fixed seat 530. The connection between the above-mentioned components may be achieved, for example, by a snap ring-groove structure or the like.

The pre-potting nose spray apparatus 500 further includes a knob 540, and the holder 530 is disposed in a front end of the holder 530. Referring specifically to fig. 18a and 18b, the knob 540 includes a rod portion 541, and a lateral hole 531 is formed at a front end of the fixing base 530, the lateral hole 531 extending in a direction substantially perpendicular to an axial direction of the pre-potting nose spray device 500, and the rod portion 541 is inserted into the lateral hole 531. In addition, a side opening 521 is formed at a side portion of the nose nozzle 520, and a rod portion 541 of the knob 540 is inserted into the side opening 521 and then inserted into the transverse hole 531 of the fixing base 530.

As shown in fig. 18b, a through hole 542 is formed in the rod portion 541 of the knob 540. The knob 540 is rotatable relative to the holder 530 to switch between aligned and offset positions of the through-hole 542 with the longitudinal channel 532 in the holder 530.

Preferably, as shown in fig. 18a and 18b, a convex ring 543 is further formed on the rod 541, which helps to keep the knob 540 inserted into the transverse hole 531 of the fixing seat 530 and prevent it from being removed.

In the closed state shown in fig. 16 and 18a, the through-hole 542 of the knob 540 is offset from the longitudinal channel 532 in the front end of the holder 530, thereby isolating the medical fluid in the syringe 510 from the external environment. In use, an operator rotates the knob 540 to align the through-hole 542 in the knob 540 with the longitudinal channel 532 in the holder 530, as shown in fig. 18b, thereby allowing the interior of the syringe 510 to communicate with the external environment, and thereby allowing the medical fluid to be sprayed outwardly.

It follows that in the fifth embodiment, the knob 540 acts as a sealed switch.

Claims (15)

1. A pre-potting nose spray device having an injector, a nose spray head and a holder, the holder being mounted on the injector, the nose spray head being connected to the holder, wherein a liquid passage is formed in the pre-potting nose spray device from an internal chamber of the injector to the nose spray head through the holder, characterized in that,

a sealing switch is provided in the liquid passage, the sealing switch being switchable between an open state in which the interior cavity of the syringe communicates with the outside via the liquid passage and a closed state in which the interior cavity of the syringe is sealed from the outside.

2. The pre-filled nasal spray device of claim 1, wherein the sealing switch comprises a sealing plug having a sealing surface formed on a front end of the holder or on a hub of the syringe, the sealing plug being capable of forming a sealing engagement with the sealing surface.

3. The pre-filled nasal spray device of claim 2, wherein the nasal spray head is movable relative to the mount along an axial direction of the pre-filled nasal spray device between a closed position in which the nasal spray head presses the sealing plug against the sealing surface and an open position in which the nasal spray head releases the pressing of the sealing plug.

4. The pre-filled nasal spray device of claim 3, wherein the mount comprises a rail portion, a top surface of the rail portion comprising a lowered surface and a raised surface;

at least one sliding block is formed on the outer surface of the outer sleeve of the nose nozzle, and the sliding block is placed on the top surface of the guide rail part;

the nose sprayer can rotate relative to the fixed seat so that the sliding block is respectively contacted with the lowering surface and the lifting surface, the nose sprayer is in the closed position relative to the fixed seat when the sliding block is contacted with the lowering surface, and the nose sprayer is in the open position relative to the fixed seat when the sliding block is contacted with the lifting surface.

5. A pre-filled nasal spray device according to claim 3, wherein the nasal spray head is arranged to be linearly movable relative to the mounting base along an axial direction of the pre-filled nasal spray device between the closed position and the open position.

6. The pre-filled nasal spray device of claim 2, wherein the sealing surface is a tapered inner surface formed in a front end of the mount or in a hub of the syringe.

7. The pre-filled nasal spray device of claim 1, wherein the sealing switch comprises an aperture, the sealing switch being movable between a closed position in which the aperture is closed and an open position in which the aperture is open.

8. The pre-filled nasal spray device of claim 7, wherein the aperture is at least one side aperture formed in a front end of the mount.

9. The pre-potting head of claim 8, wherein the head includes a head inner sleeve having an inner diameter that is set smaller than an outer diameter of a portion of the front end of the holder where the side hole is formed, such that the portion of the front end where the side hole is formed is interference fit with the head inner sleeve, and at least one flow guide groove is formed in the head inner sleeve;

wherein the nose cup is rotatable relative to the mount between the closed position in which the side holes are offset from the channels and the open position in which the side holes are aligned with the channels.

10. The pre-potting head nasal spray device of claim 8, wherein the nasal spray head comprises a head inner sleeve having a large inner diameter portion and a small inner diameter portion formed therein, the small inner diameter portion having an inner diameter smaller than an outer diameter of a portion of the front end of the fixing base where the side hole is formed, such that the portion of the front end of the fixing base where the side hole is formed forms an interference fit with the small inner diameter portion, and an inner diameter of the large inner diameter portion is larger than an outer diameter of a portion of the front end of the fixing base where the side hole is formed;

wherein the nasal spray head is linearly movable relative to the holder in an axial direction of the pre-potting head between the closed position in which the portion of the front end of the holder in which the side aperture is formed is interference fit with the small inner diameter portion and the open position in which the portion of the front end of the holder in which the side aperture is formed is in the large inner diameter portion.

11. The pre-filled nasal spray device of claim 10, wherein a recess is formed in the nasal spray head and a peripheral flange is formed on the mount, the peripheral flange fitting into the recess when the nasal spray head is connected to the mount, wherein the width of the recess is greater than the width of the peripheral flange, thereby allowing linear movement of the nasal spray head relative to the mount.

12. The pre-filled nasal spray device of claim 7, wherein the sealing switch comprises a knob comprising a stem, the aperture being a through-hole formed in the stem;

a transverse hole is formed in the fixing seat, the transverse hole extends along the direction perpendicular to the axial direction of the pre-potting nose spraying device, and the rod part is inserted into the transverse hole of the fixing seat;

wherein the knob is rotatable between a closed position in which the through-hole is offset from the longitudinal passage of the holder and an open position in which the through-hole is aligned with the longitudinal passage.

13. The pre-filled nasal spray device of claim 1, wherein the nasal spray head or the mounting base is integrally formed with or connected to a thumbplate.

14. The pre-filled nasal spray device of claim 13, wherein a stop catch is provided between the thumbplate and a flange on the rear end of the syringe.

15. The pre-filled nasal spray device of claim 13, wherein at least one frangible member is provided between the thumbplate and a flange on the rear end of the syringe.