CN117797359B - Injection pump control system for transdermal administration - Google Patents
Injection pump control system for transdermal administration Download PDFInfo
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- CN117797359B CN117797359B CN202410045977.9A CN202410045977A CN117797359B CN 117797359 B CN117797359 B CN 117797359B CN 202410045977 A CN202410045977 A CN 202410045977A CN 117797359 B CN117797359 B CN 117797359B
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- 238000002347 injection Methods 0.000 title claims abstract description 163
- 239000007924 injection Substances 0.000 title claims abstract description 163
- 238000012549 training Methods 0.000 claims abstract description 68
- 239000003814 drug Substances 0.000 claims abstract description 51
- 229940079593 drug Drugs 0.000 claims abstract description 43
- 238000001647 drug administration Methods 0.000 claims abstract description 30
- 230000004044 response Effects 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 24
- 230000008569 process Effects 0.000 claims abstract description 23
- 230000036760 body temperature Effects 0.000 claims description 33
- 230000036772 blood pressure Effects 0.000 claims description 32
- 238000007789 sealing Methods 0.000 claims description 13
- 238000012377 drug delivery Methods 0.000 claims description 6
- 238000013271 transdermal drug delivery Methods 0.000 claims description 3
- 210000001503 joint Anatomy 0.000 description 9
- 230000001105 regulatory effect Effects 0.000 description 5
- 230000035487 diastolic blood pressure Effects 0.000 description 3
- 230000035488 systolic blood pressure Effects 0.000 description 3
- 206010039897 Sedation Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000010999 medical injection Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- 239000000932 sedative agent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
- A61M2230/06—Heartbeat rate only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/30—Blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/50—Temperature
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Theoretical Computer Science (AREA)
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- Anesthesiology (AREA)
- Evolutionary Computation (AREA)
- Physics & Mathematics (AREA)
- Computing Systems (AREA)
- Vascular Medicine (AREA)
- Artificial Intelligence (AREA)
- Mathematical Physics (AREA)
- Data Mining & Analysis (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a transdermal administration injection pump control system, which relates to the technical field of injection pumps and comprises an injection pump main body, wherein the top surface of the injection pump main body is provided with a control panel, and one side of the injection pump main body is provided with a driving arm; the control module is arranged in the control panel, and is used for collecting a historical training data set of the injection pump main body in advance and training a drug administration control model of the injection pump main body based on the historical training data set; the control module collects the drug response data of the injection pump main body in the real-time injection process, and predicts the drug administration rate of the injection pump main body by using a drug administration control model according to the drug response data; the trained drug control model predicts the drug administration rate of the injection pump main body according to the drug reaction data, and when special conditions are met, the injection pump main body can automatically adjust the drug administration rate, so that the safety of the drug administration process of the injection pump main body is greatly improved.
Description
Technical Field
The invention relates to the technical field of injection pumps, in particular to a transdermal administration injection pump control system.
Background
An existing injection pump control system, such as an electroencephalogram monitoring sedation depth closed-loop control injection pump device disclosed in China patent publication No. CN103735261A, acquires an original electroencephalogram signal of a human body through a set electroencephalogram data acquisition module, converts the original electroencephalogram signal into a quantitative data index capable of monitoring sedation depth, determines sedative drug administration parameter information according to the quantitative data index, and performs sedative drug injection quantity control according to the administration parameter information, so that personalized drug administration and accurate drug administration are realized. The injection pump disclosed in China patent publication No. CN108653871B measures the distance between the injector and the push head by arranging a distance sensor on the push head, so as to avoid the problem that the injection rising time is too long to influence the infusion precision due to overlarge gap between the push head and the injector piston.
The above-mentioned patent can not carry out real-time adjustment according to patient's physical reaction in the use, when patient's health appears unusual circumstances, can't in time make the adjustment, causes the influence to patient's health easily, and in the in-process that syringe pump promotes the syringe, the accuracy of control syringe is relatively poor, leads to dosage control inaccuracy.
Disclosure of Invention
In order to overcome the technical problems, the invention aims to provide a transdermal administration injection pump control system, which solves the problems that in the prior art, the injection pump cannot be adjusted in time when abnormal conditions occur to the body of a patient because the real-time adjustment cannot be performed according to the body reaction of the patient.
The aim of the invention can be achieved by the following technical scheme:
in particular to a control system of a syringe pump for transdermal administration, which comprises the following components:
The injection pump comprises an injection pump main body, wherein the top surface of the injection pump main body is provided with a control panel, and one side of the injection pump main body is provided with a driving arm;
The control module is arranged in the control panel, and is used for collecting a historical training data set of the injection pump main body in advance and training a drug administration control model of the injection pump main body based on the historical training data set;
the control module collects the drug response data of the injection pump main body in the real-time injection process, and predicts the drug administration rate of the injection pump main body by using a drug administration control model according to the drug response data.
As a further scheme of the invention: the historical training data set is collected in clinical treatment, and one administration process of the injection pump main body is a group of training data;
The historical training data set comprises N groups of training data, wherein N is a positive integer greater than 0, and each group of training data comprises drug response data and drug administration rate;
the drug response data includes body temperature data, heart rate data, blood pressure data, and resistance data;
The body temperature data is the body temperature value of a patient connected with the injection pump main body for injection;
the heart rate data is a heart rate value of a patient connected with the injection pump main body for injection;
The blood pressure data is the blood pressure value of a patient connected with the injection pump main body for injection;
The resistance data is a resistance value received by the injection pump main body in the injection process.
As a further scheme of the invention: the training mode of the drug administration control model is as follows:
The drug response data in each group of training data are converted into training parameters, each group of training parameters is used as the input of a drug control model, the predicted drug administration rate of each group of training parameters by the drug control model is used as the output, the drug administration rate of the injection pump main body (1) corresponding to each group of drug response data is used as a prediction target, and the sum of the prediction accuracy of all training parameters is minimized to be used as a training target;
The calculation formula of the prediction accuracy is Zi= (Yi-Xi) 2, wherein Zi is the prediction accuracy, yi is the predicted administration rate corresponding to the ith group of training parameters, and Xi is the administration rate corresponding to the ith group of drug response data;
and training the medicine control model until the sum of the prediction accuracy reaches convergence, and stopping training.
As a further scheme of the invention: the calculation formula of the administration rate is as follows:
Vi＝V0-M(f，t，n，p)；
wherein Vi is the administration rate of the syringe pump body, V 0 is the preset administration rate of the syringe pump body, M (f, t, n, p) is the training parameter coefficient, and f, t, n and p represent the resistance parameter, the body temperature parameter, the heart rate parameter and the blood pressure parameter, respectively.
As a further scheme of the invention: the calculation formula of the resistance parameter coefficient is M (f) =a× (f-f 0)2;
Wherein a is a proportionality coefficient larger than 0, f 0 is preset resistance data of the injection pump main body, and f is real-time resistance data of the injection pump main body.
As a further scheme of the invention: the calculation formulas of the body temperature parameter, the heart rate parameter and the blood pressure parameter are respectively as follows:
M(t)＝b×floor(t-t0)2；
Wherein M (t) is a body temperature parameter, b is a proportionality coefficient larger than 0, t 0 is preset body temperature data, and t is real-time body temperature data;
M(n)＝c×floor[(n-n0)2/10]；
Wherein M (n) is a heart rate parameter, c is a proportionality coefficient larger than 0, n 0 is preset heart rate data, and n is real-time heart rate data;
M(p)＝d×floor[(m-m0)2/10]；
wherein M (p) is a blood pressure parameter, d is a proportionality coefficient larger than 0, M 0 is preset blood pressure data, and M is real-time blood pressure data.
As a further scheme of the invention: the driving arm comprises a driving rod, one end of the outer side of the driving rod is fixedly connected with a movable seat, one side of the movable seat is provided with a sealing end cover, and the other side of the movable seat is provided with an injection pushing plate.
As a further scheme of the invention: an adjusting plate is arranged between the sealing end cover and the injection pushing plate, a supporting spring is fixedly connected between the injection pushing plate and the adjusting plate, a communicating pipe is fixedly connected to the circle center position of one side, far away from the supporting spring, of the adjusting plate, an electromagnetic valve is arranged in the communicating pipe, and one end, far away from the adjusting plate, of the communicating pipe penetrates through the sealing end cover.
As a further scheme of the invention: the outside of communicating pipe has seted up the screw thread groove, and the outside nestification of communicating pipe has ball nut, and ball nut movable mounting is covered at the sealed end.
As a further scheme of the invention: and a pressure sensor is arranged on one side of the injection pushing plate far away from the supporting spring.
The invention has the beneficial effects that:
1. According to the invention, the control module is arranged on the control panel, the control module converts the drug response data in each group of training data into training parameters, each group of training parameters is used as the input of a drug control model, the drug control model predicts the drug administration rate of each group of training parameters and takes the drug administration rate of the injection pump main body corresponding to each group of drug response data as a prediction target, and the sum of the prediction accuracy of all training parameters is minimized and taken as the training target; the calculation formula of the prediction accuracy is Zi= (Yi-Xi), wherein Zi is the prediction accuracy, yi is the predicted administration rate corresponding to the ith group of training parameters, and Xi is the administration rate corresponding to the ith group of drug response data; training the medicine control model until the sum of the prediction accuracy reaches convergence, stopping training, predicting the medicine feeding rate of the injection pump main body according to the medicine response data by the trained medicine control model, and automatically adjusting the medicine feeding rate by the injection pump main body when special conditions are met, so that the safety of the medicine feeding process of the injection pump main body is greatly improved.
2. In the invention, in the process of quickly approaching the injector by the arranged driving arm, when the surface of the injection push plate contacts the injector, the injection push plate can not push the injector, and a butt joint terminal is arranged between the injection push plate and the regulating plate, wherein the butt joint terminal is a start switch for setting the pushing speed of the injection push plate to be the drug delivery rate, namely, in the process of moving the injection push plate backwards, when the butt joint terminal between the injection push plate and the regulating plate is connected, the speed of the injection push plate is instantly regulated to be the drug delivery rate, because the injection push plate is necessarily in good contact with the injector when the injection pump main body pushes the injector by the injection push plate, the injection pump main body ensures the drug delivery accuracy of the injector.
3. According to the invention, through the adjusting plate, supporting springs with different elasticity are improved for injectors with different specifications, one end of the butt-joint terminal is fixed on the side face of the injection pushing plate, and the other end of the butt-joint terminal is fixed in the middle position inside the control cavity, so that the distance between two ends of the butt-joint terminal cannot be changed, the position of the adjusting plate can be adjusted through the micro motor, and the injection pushing plate can be ensured to receive different elasticity.
Drawings
The invention is further described below with reference to the accompanying drawings.
FIG. 1 is a schematic diagram of the structure of a control system of a syringe pump for transdermal administration according to the present invention;
FIG. 2 is a schematic view of the structure of the driving arm in the present invention;
FIG. 3 is a front view of the mobile station of the present invention;
FIG. 4 is a cross-sectional view of the mobile station of the present invention;
FIG. 5 is a schematic view of the structure of the adjusting plate of the present invention;
Fig. 6 is a system flow diagram of a transdermal drug delivery syringe pump control system of the present invention.
In the figure: 1. a syringe pump body; 2. a control panel; 3. a syringe groove; 4. a limiting clamp; 5. a driving arm; 51. a driving rod; 52. a movable seat; 521. a control chamber; 53. sealing the end cover; 531. a ball nut; 54. injecting a push plate; 541. a butt-joint terminal; 55. a support spring; 56. an adjusting plate; 57. a communicating pipe; 58. a solenoid valve.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1:
As shown in fig. 1 and 6, the invention discloses a transdermal administration injection pump control system, which comprises an injection pump main body 1, wherein the top surface of the injection pump main body 1 is provided with a control panel 2, one side of the injection pump main body 1 is provided with a driving arm 5, a control module is arranged in the control panel 2, the control module collects a historical training data set of the injection pump main body 1 in advance, and an administration control model of the injection pump main body 1 is trained based on the historical training data set; the control module collects the drug response data of the injection pump main body 1 in the real-time injection process, and predicts the drug administration rate of the injection pump main body 1 by using a drug administration control model according to the drug response data;
The historical training data set is collected in clinical treatment, and one administration process of the injection pump main body 1 is a group of training data; the historical training data set comprises N groups of training data, wherein N is a positive integer greater than 0, and each group of training data comprises drug response data and drug administration rate; the drug response data includes body temperature data, heart rate data, blood pressure data, and resistance data;
The body temperature data is the body temperature value of a patient connected with the injection pump main body 1 for injection; the heart rate data is the heart rate value of a patient connected with the injection pump main body 1 for injection; the blood pressure data is the blood pressure value of the patient connected with the injection pump main body 1 for injection; the resistance data is the resistance value received by the injection pump main body 1 in the injection process;
When the injection pump main body 1 is used for administration, a patient can monitor the change of the body temperature of the patient in real time through a thermometer, and the thermometer can convey the body temperature value of the patient to a control module, so that the control module can acquire the body temperature data of the patient in real time;
the heart rate data and the blood pressure data can be measured in real time by using the existing equipment of a hospital, and the measured heart rate data and blood pressure data are transmitted to the control module, so that the control module can acquire the heart rate data and the blood pressure data of the patient in real time.
The training mode of the administration control model is as follows:
The drug response data in each group of training data are converted into training parameters, each group of training parameters is used as the input of a drug control model, the predicted drug administration rate of each group of training parameters by the drug control model is used as the output, the drug administration rate of the injection pump main body 1 corresponding to each group of drug response data is used as a prediction target, and the sum of the prediction accuracy of all training parameters is minimized to be used as a training target; the calculation formula of the prediction accuracy is Zi= (Yi-Xi) 2, wherein Zi is the prediction accuracy, yi is the predicted administration rate corresponding to the ith group of training parameters, and Xi is the administration rate corresponding to the ith group of drug response data; the drug control model is trained until the sum of the prediction accuracy reaches convergence, and the convergence judgment standard is set according to specific model training conditions by a person skilled in the art.
The dosage rate was calculated as:
Vi＝V0-M(f，t，n，p)；
Wherein Vi is the administration rate of the syringe pump body 1, V 0 is the administration rate preset by the syringe pump body 1, M (f, t, n, p) is the training parameter coefficient, and f, t, n and p represent the resistance parameter, the body temperature parameter, the heart rate parameter and the blood pressure parameter, respectively.
The calculation formula of the resistance parameter coefficient is M (f) =a× (f-f 0)2;
wherein a is a proportionality coefficient larger than 0, f 0 is resistance data preset by the injection pump main body 1, f is resistance data of the injection pump main body 1 in real time, and it is to be noted that the resistance data refers to resistance of the injection pump main body 1 in the patient body during administration, so that the resistance data needs to remove friction force of the injector, and in the actual use process of the injection pump main body 1, whether the resistance data of the injection pump main body 1 is large or small is in an abnormal state, so that the administration rate of the injection pump main body 1 needs to be reduced, the reduction of the administration rate of the injection pump main body 1 is regulated by the proportionality coefficient a, and the value of the proportionality coefficient a is given by an administration control model in the training process.
The calculation formulas of the body temperature parameter, the heart rate parameter and the blood pressure parameter are respectively as follows:
M(t)＝b×floor(t-t0)2；
wherein M (t) is a body temperature parameter, b is a proportionality coefficient larger than 0, t 0 is preset body temperature data, t is real-time body temperature data, floor function is a downward rounding function, because the body temperature of a human body is a dynamic balance, the fluctuation range is smaller than one degree, when the body temperature parameter calculated by 'M (t) =b×floor (t-t 0)2' is about to be the body temperature fluctuation of a patient to be normal, the difference of t-t 0 is proved to be smaller than 1, so that the value of floor (t-t 0)2) can be taken to be 0, the body temperature parameter can be ignored, but when the difference of t-t 0 is larger than 1, that is, the body temperature of the patient is changed by more than 1 degree in the process of administration through the injection pump main body 1, the administration of the injection pump main body 1 needs to be stopped, and therefore, the proportionality coefficient of b can be directly set to be V 0;
once the body temperature of the patient is monitored to be changed by more than 1 degree, the injection pump main body 1 can immediately stop the administration, so that the life safety of the patient is ensured;
M(n)＝c×floor[(n-n0)2/10]；
Wherein M (n) is a heart rate parameter, c is a proportionality coefficient larger than 0, n 0 is preset heart rate data, n is real-time heart rate data, and it is required to be noted that the fluctuation of heart rate data of a patient is larger, so that the difference between n and n 0 can be reduced and set, for example, the difference is reduced by 10 times, that is, the fluctuation of the heart rate of the patient exceeds 10, the injection pump main body 1 is correspondingly regulated, the value of the proportionality coefficient c is correspondingly smaller, for example, the value is set to 0.25V 0, that is, when the heart rate of the patient changes, the administration of the injection pump main body 1 is properly reduced, and if the heart rate of the patient continuously increases or decreases, the abnormality of the body of the patient is indicated, and at the moment, the administration of the injection pump main body 1 can be stopped;
M(p)＝d×floor[(m-m0)2/10]；
wherein M (p) is a blood pressure parameter, d is a proportionality coefficient larger than 0, M 0 is preset blood pressure data, M is real-time blood pressure data, and it is required to be explained that blood of a human body is divided into systolic pressure and diastolic pressure, so that a calculation formula of the blood pressure parameter needs to be further refined:
M(p)＝d×floor[[(m Shrinking process -m1)+(m Sheet of paper -m2)]2/10]；
Wherein m Shrinking process is the real-time systolic pressure of the patient, m Sheet of paper is the real-time diastolic pressure of the patient, m 1 is the preset systolic pressure, and m 2 is the preset diastolic pressure;
In addition, it should be noted that the blood pressure of the human body is also dynamically balanced and fluctuates greatly, so that the setting of the blood pressure parameter is similar to the setting of the heart rate parameter, and the value of the proportionality coefficient d is also correspondingly smaller, for example, the value is set to 0.25V 0, namely, when the blood pressure of the patient changes, the administration of the syringe pump main body 1 is properly reduced, if the blood pressure of the patient continuously increases or decreases, the abnormality of the body of the patient is indicated, and at this time, the administration of the syringe pump main body 1 can be stopped;
m (f), M (t), M (n) and M (p) are combined, and then:
Vi＝V0-(a×(f-f0)2+b×floor(t-t0)2+c×floor[(n-n0)2/10]+d×floor[(m-m0)
2/10])。
Example 2:
As shown in fig. 1-5, the invention discloses a transdermal administration injection pump control system, which comprises an injection pump main body 1, wherein the top surface of the injection pump main body 1 is provided with a control panel 2, one side of the injection pump main body 1 is provided with a driving arm 5, the driving arm 5 comprises a driving rod 51, one end of the outer side of the driving rod 51 is fixedly connected with a movable seat 52, one side of the movable seat 52 is provided with a sealing end cover 53, the other side of the movable seat 52 is provided with an injection push plate 54, the front surface of the injection pump main body 1 is provided with an injection groove 3 near the driving arm 5, one end of the injection groove 3 is provided with a limiting clamp 4, and when in use, an injector can be placed in the injection groove 3, then the injector is fixed in the injection groove 3 through the limiting clamp 4, and then the output end of the injector is connected with a medical injection needle through a pipeline, so that the preparation work of the injection pump main body 1 is completed;
At the moment, medical staff can preset proper administration rate according to the physical information of a patient and medicines to be injected, and then can administer the medicines to the patient;
Specifically, medical staff inserts a medical injection needle into a patient, which can be muscle administration or vein administration, and then opens the injection pump main body 1 through the control panel 2;
The driving mechanism inside the syringe pump body 1 can push the driving rod 51, and the driving rod 51 drives the injection push plate 54 through the moving seat 52.
As shown in fig. 4 and 5, an adjusting plate 56 is arranged between a sealing end cover 53 and an injection pushing plate 54, a supporting spring 55 is fixedly connected between the injection pushing plate 54 and the adjusting plate 56, a communicating pipe 57 is fixedly connected to the center of a circle of one side of the adjusting plate 56 away from the supporting spring 55, an electromagnetic valve 58 is arranged in the communicating pipe 57, and one end of the communicating pipe 57 away from the adjusting plate 56 penetrates through the sealing end cover 53;
It should be emphasized that, since the injection pump main body 1 is used to administer the drug, the drug is pushed at a very slow speed, and the drug is administered for up to 30 ml only after one hour, the push plate 54 is pushed at a very slow speed, so that a small amount of drug can be ensured to enter the human body;
The working mode of the injection pump main body 1 is divided into two stages, wherein the first stage is that before the injection push plate 54 pushes the injector, the injection push plate 54 needs to be quickly close to the injector, and the second stage is that when the injection push plate 54 pushes the injector, the pushing speed of the injection push plate 54 needs to be in accordance with the preset administration speed, which is quickly equivalent to the quick administration speed, and in fact, the pushing speed of the injection push plate 54 can be set to be 0.3-0.5 ml/s at the moment;
the first stage:
That is, before the injection push plate 54 pushes the injector, in the process that the injection push plate 54 is quickly approaching the injector, when the surface of the injection push plate 54 contacts the injector, the elastic force of the supporting spring 55 is smaller than the maximum static friction force of the injector, that is, the injection push plate 54 does not push the injector in the process of overcoming the movement of the supporting spring 55, and a butt joint terminal 541 is further arranged between the injection push plate 54 and the adjusting plate 56, wherein the butt joint terminal 541 is a start switch for setting the pushing speed of the injection push plate 54 to the drug delivery rate, that is, when the butt joint terminal 541 between the injection push plate 54 and the adjusting plate 56 is connected in the process that the injection push plate 54 moves backwards, the speed of the injection push plate 54 is instantly adjusted to the drug delivery rate;
The purpose of this arrangement is to ensure the accuracy of administration of the syringe pump body 1 because the syringe pump body 1 must be in good contact with the syringe by the injection push plate 54 when the syringe is pushed by the injection push plate 54, and thus the syringe pump body 1 ensures the accuracy of administration of the syringe;
example 3:
As shown in fig. 4, the butt-joint terminal 541 also controls the solenoid valve 58 inside the communicating tube 57, when the butt-joint terminal 541 between the injection push plate 54 and the adjustment plate 56 is turned on, the butt-joint terminal 541 immediately controls the solenoid valve 58 to be turned off, in order to ensure that the position of the injection push plate 54 is limited after the solenoid valve 58 is turned off, liquid water can be added into the control chamber 521, and one end of the communicating tube 57, which is far away from the adjustment plate 56, is connected with a water storage tube, which is provided on the movable seat 52, so that the volume of the control chamber 521 is limited when the solenoid valve 58 is turned off, and thus the position of the injection push plate 54 is limited.
Example 4:
As shown in fig. 5, a threaded groove is formed in the outer side of the communicating tube 57, a ball nut 531 is nested in the outer side of the communicating tube 57, the ball nut 531 is movably mounted on the sealing end cover 53, it is to be noted that a micro motor is mounted on the inner side of the sealing end cover 53, an output shaft of the micro motor is meshed with a side surface of the ball nut 531 through a gear, when the micro motor is opened, the output shaft of the micro motor can drive the ball nut 531 to rotate through the gear, the rotating ball nut 531 can drive the communicating tube 57 to drive the adjusting plate 56 to move, and the purpose of the arrangement is that for injectors of different specifications, supporting springs 55 with different elastic forces are improved, one ends of the butt joint terminals 541 are fixed on the side surface of the injection pushing plate 54, the other ends of the butt joint terminals 541 are fixed on the inner middle position of the control cavity 521, and therefore, the distance between the two ends of the butt joint terminals 541 can not be changed, and the position of the adjusting plate 56 can be adjusted through the micro motor, so that the injection pushing plate 54 can receive different elastic forces.
The side of the injection push plate 54 away from the supporting spring 55 is provided with a pressure sensor which acquires the extrusion force of the injector to the injection push plate 54, namely the resistance data of the injection pump main body 1, in real time during the process of pushing the injector by the injection push plate 54.
The foregoing describes one embodiment of the present invention in detail, but the description is only a preferred embodiment of the present invention and should not be construed as limiting the scope of the invention. All equivalent changes and modifications within the scope of the present invention are intended to be covered by the present invention.
Claims (4)
1. A syringe pump control system for transdermal administration, comprising:
the injection pump comprises an injection pump main body (1), wherein a control panel (2) is arranged on the top surface of the injection pump main body (1), and a driving arm (5) is arranged on one side of the injection pump main body (1);
the control module is arranged in the control panel (2), and is used for collecting a historical training data set of the injection pump main body (1) in advance and training a drug administration control model of the injection pump main body (1) based on the historical training data set;
the control module collects the drug response data of the injection pump main body (1) in the real-time injection process, and predicts the drug administration rate of the injection pump main body (1) by using a drug administration control model according to the drug response data;
the historical training data set is collected in clinical treatment, and one administration process of the injection pump main body (1) is a group of training data;
The historical training data set comprises N groups of training data, wherein N is a positive integer greater than 0, and each group of training data comprises drug response data and drug administration rate;
the drug response data includes body temperature data, heart rate data, blood pressure data, and resistance data;
the body temperature data is the body temperature value of a patient connected with the injection pump main body (1);
the heart rate data is a heart rate value of a patient connected with the injection pump main body (1);
the blood pressure data is the blood pressure value of a patient connected with the injection pump main body (1);
the resistance data is a resistance value received by the injection pump main body (1) in the injection process;
the training mode of the drug administration control model is as follows:
The drug response data in each group of training data are converted into training parameters, each group of training parameters is used as the input of a drug control model, the predicted drug administration rate of each group of training parameters by the drug control model is used as the output, the drug administration rate of the injection pump main body (1) corresponding to each group of drug response data is used as a prediction target, and the sum of the prediction accuracy of all training parameters is minimized to be used as a training target;
The calculation formula of the prediction accuracy is Zi= (Yi-Xi) 2, wherein Zi is the prediction accuracy, yi is the predicted administration rate corresponding to the ith group of training parameters, and Xi is the administration rate corresponding to the ith group of drug response data;
training the medicine control model until the sum of prediction accuracy reaches convergence, and stopping training;
The driving arm (5) comprises a driving rod (51), one end of the outer side of the driving rod (51) is fixedly connected with a movable seat (52), one side of the movable seat (52) is provided with a sealing end cover (53), and the other side of the movable seat (52) is provided with an injection pushing plate (54);
An adjusting plate (56) is arranged between the sealing end cover (53) and the injection pushing plate (54), a supporting spring (55) is fixedly connected between the injection pushing plate (54) and the adjusting plate (56), a communicating pipe (57) is fixedly connected to the center of a circle of one side, far away from the supporting spring (55), of the adjusting plate (56), an electromagnetic valve (58) is arranged in the communicating pipe (57), and one end, far away from the adjusting plate (56), of the communicating pipe (57) penetrates through the sealing end cover (53);
a thread groove is formed in the outer side of the communicating pipe (57), a ball nut (531) is nested in the outer side of the communicating pipe (57), and the ball nut (531) is movably arranged on the sealing end cover (53);
and a pressure sensor is arranged on one side of the injection push plate (54) away from the supporting spring (55).
2. The transdermal drug delivery syringe pump control system of claim 1, wherein the drug delivery rate is calculated as:
Vi＝V0-M(f，t，n，p)；
wherein Vi is the administration rate of the syringe pump main body (1), V 0 is the administration rate preset by the syringe pump main body (1), M (f, t, n, p) is the training parameter coefficient, and f, t, n and p respectively represent the resistance parameter, the body temperature parameter, the heart rate parameter and the blood pressure parameter.
3. A transdermal drug delivery syringe pump control system according to claim 2, wherein the calculation formula of the drag parameter coefficient is M (f) =a× (f-f 0)2;
Wherein a is a proportionality coefficient larger than 0, f 0 is preset resistance data of the injection pump main body (1), and f is real-time resistance data of the injection pump main body (1).
4. A transdermal administration pump control system as claimed in claim 3, wherein the calculation formulas of the body temperature parameter, the heart rate parameter and the blood pressure parameter are respectively:
M(t)＝b×floor(t-t0)2；
Wherein M (t) is a body temperature parameter, b is a proportionality coefficient larger than 0, t 0 is preset body temperature data, and t is real-time body temperature data;
M(n)＝c×floor[(n-n0)2/10]；
Wherein M (n) is a heart rate parameter, c is a proportionality coefficient larger than 0, n 0 is preset heart rate data, and n is real-time heart rate data;
M(p)＝d×floor[(m-m0)2/10]；
wherein M (p) is a blood pressure parameter, d is a proportionality coefficient larger than 0, M 0 is preset blood pressure data, and M is real-time blood pressure data.
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Citations (2)
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|---|---|---|---|---|
| WO1997034648A1 (en) * | 1996-03-18 | 1997-09-25 | Masson Jean Pierre | Apparatus for controlling an intravenous injection |
| CN103735261A (en) * | 2013-12-05 | 2014-04-23 | 北京思路高医疗科技有限公司 | Brain electricity monitoring sedation depth close loop control injection pump device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2580307A (en) * | 2018-12-12 | 2020-07-22 | Osama Al Baalbaky Alaa | Smart self-monitored syringe infusion pump |
| EP4035709A4 (en) * | 2019-09-25 | 2022-09-07 | Shenzhen Mindray Scientific Co., Ltd. | Syringe pump, method for confirming infusion information, medical device and storage medium |
| KR102477128B1 (en) * | 2020-06-01 | 2022-12-13 | 한국표준과학연구원 | Automatic injection system capable of realtime monitoring |
| KR102234007B1 (en) * | 2020-07-14 | 2021-03-31 | 고려대학교 산학협력단 | Device and method for controlling drug injection using reinforced learning |
| CN112007239B (en) * | 2020-09-24 | 2021-06-04 | 浙江迈帝康医疗器械有限公司 | Injection pump |
| CN115040723A (en) * | 2022-05-26 | 2022-09-13 | 深圳市宝安区中医院 | Remote control infusion system of injection pump |
| CN116850383A (en) * | 2023-08-09 | 2023-10-10 | 臧英男 | Target control injection control module |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997034648A1 (en) * | 1996-03-18 | 1997-09-25 | Masson Jean Pierre | Apparatus for controlling an intravenous injection |
| CN103735261A (en) * | 2013-12-05 | 2014-04-23 | 北京思路高医疗科技有限公司 | Brain electricity monitoring sedation depth close loop control injection pump device |
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