CN117771147B - An anti-ultraviolet and sunscreen composition and its preparation method and application - Google Patents
An anti-ultraviolet and sunscreen composition and its preparation method and application Download PDFInfo
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- CN117771147B CN117771147B CN202311761737.0A CN202311761737A CN117771147B CN 117771147 B CN117771147 B CN 117771147B CN 202311761737 A CN202311761737 A CN 202311761737A CN 117771147 B CN117771147 B CN 117771147B
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- 230000000475 sunscreen effect Effects 0.000 title claims abstract 20
- 239000000516 sunscreening agent Substances 0.000 title claims abstract 20
- 239000000203 mixture Substances 0.000 title claims abstract 7
- 238000002360 preparation method Methods 0.000 title claims abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract 12
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract 10
- 239000000419 plant extract Substances 0.000 claims abstract 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract 5
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract 5
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract 5
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims abstract 5
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims abstract 5
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims abstract 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract 5
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract 5
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract 5
- 229940036350 bisabolol Drugs 0.000 claims abstract 5
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract 5
- 229960002442 glucosamine Drugs 0.000 claims abstract 5
- -1 glycosyl trehalose Chemical compound 0.000 claims abstract 5
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract 5
- 229940032094 squalane Drugs 0.000 claims abstract 5
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims abstract 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract 4
- 229920001353 Dextrin Polymers 0.000 claims abstract 4
- 239000004375 Dextrin Substances 0.000 claims abstract 4
- 235000019425 dextrin Nutrition 0.000 claims abstract 4
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims abstract 4
- 229940114124 ferulic acid Drugs 0.000 claims abstract 4
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims abstract 4
- 235000001785 ferulic acid Nutrition 0.000 claims abstract 4
- 239000002994 raw material Substances 0.000 claims abstract 4
- 239000011734 sodium Substances 0.000 claims abstract 4
- 229910052708 sodium Inorganic materials 0.000 claims abstract 4
- 239000000600 sorbitol Substances 0.000 claims abstract 4
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract 4
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims abstract 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract 2
- 229960003966 nicotinamide Drugs 0.000 claims abstract 2
- 235000005152 nicotinamide Nutrition 0.000 claims abstract 2
- 239000011570 nicotinamide Substances 0.000 claims abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 8
- 238000003756 stirring Methods 0.000 claims 5
- 239000005543 nano-size silicon particle Substances 0.000 claims 4
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims 4
- 235000012239 silicon dioxide Nutrition 0.000 claims 4
- 239000011787 zinc oxide Substances 0.000 claims 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- 239000000284 extract Substances 0.000 claims 3
- 229960005150 glycerol Drugs 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229960002920 sorbitol Drugs 0.000 claims 3
- 239000008213 purified water Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 240000007171 Imperata cylindrica Species 0.000 claims 1
- 244000269722 Thea sinensis Species 0.000 claims 1
- 229940082463 angelica sinensis root extract Drugs 0.000 claims 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims 1
- 229940087603 grape seed extract Drugs 0.000 claims 1
- 235000002532 grape seed extract Nutrition 0.000 claims 1
- 229940084750 sophora flavescens root extract Drugs 0.000 claims 1
- 239000001717 vitis vinifera seed extract Substances 0.000 claims 1
- 206010042496 Sunburn Diseases 0.000 abstract 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
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Abstract
本发明提供一种抗紫外线、防晒组合物及其制备方法和应用，原料包括：植物提取物20～32份、物理防晒剂7～12份、红没药醇0.1～2份、糖基海藻糖4～8份、角鲨烷4～10份、生育酚乙酸酯0.5～2份、烟酰胺3～8份、羧甲基糊精钠3～9份、葡糖胺1～4份、甘油丙烯酸酯/丙烯酸共聚物1～5份、阿魏酸0～7份、山梨糖醇1～7份、甘油2～5份。本发明通过植物提取物、物理防晒剂为主要的防晒物质，同时协同红没药醇、角鲨烷、糖基海藻糖、生育酚乙酸酯、烟酰胺、葡糖胺、甘油丙烯酸酯/丙烯酸共聚物等组分，能够形成稳定的防晒体系，能够协同增效起到良好的防晒效果，同时在各个组分的相互作用下，对肌肤进行防护保持水分，在使用过程中不干燥，保持水油平衡，延展性也更好，不粘腻，减少皮肤的晒伤。The invention provides an anti-ultraviolet and sunscreen composition, a preparation method and application thereof. The raw materials include: 20-32 parts of plant extracts, 7-12 parts of physical sunscreens, 0.1-2 parts of bisabolol, 4-8 parts of glycosyl trehalose, 4-10 parts of squalane, 0.5-2 parts of tocopherol acetate, 3-8 parts of nicotinamide, 3-9 parts of sodium carboxymethyl dextrin, 1-4 parts of glucosamine, 1-5 parts of glyceryl acrylate/acrylic acid copolymer, 0-7 parts of ferulic acid, 1-7 parts of sorbitol and 2-5 parts of glycerol. The present invention uses plant extracts and physical sunscreens as main sunscreen substances, and cooperates with components such as bisabolol, squalane, glycosyl trehalose, tocopheryl acetate, niacinamide, glucosamine, glyceryl acrylate/acrylic acid copolymer, etc. to form a stable sunscreen system, which can synergistically enhance the effect of sunscreen. At the same time, under the interaction of various components, the skin is protected and moisture is retained, the skin does not dry out during use, the water-oil balance is maintained, the ductility is better, the skin is not sticky, and sunburn of the skin is reduced.
Description
Technical Field
The invention relates to the technical field of skin care, in particular to an ultraviolet-resistant and sun-proof composition, a preparation method and application thereof.
Background
With the acceleration of the pace of life of people, irregular life work and rest and incorrect skin care habits lead to an increasing skin burden. In addition, as the environment is destroyed, the ultraviolet light is more and more stimulated, and the skin epidermis is damaged when people are exposed to the ultraviolet light for a long time, so that the skin becomes dark and dry, and the skin is inflamed, burned, skin cancer and the like are also caused. In order to prevent the damage of ultraviolet rays to the skin, sun protection products are used for protection. The main role in sunscreen products is to be taken into account by sunscreens. Sunscreens are generally classified into physical sunscreens mainly comprising titanium dioxide, zinc oxide, talc and the like, and are mainly protected by reflecting and scattering ultraviolet rays, and chemical sunscreens mainly converting the energy of ultraviolet rays into heat energy after absorbing the ultraviolet rays and releasing the heat energy. The physical sun-screening agent is not easy to be allergic, but is possibly light and thin enough, white marks are easy to be left after the application, and the sun-screening agent is easy to be washed away by water, so that the sun-screening agent is inconvenient to use; the chemical sunscreen agent has a relatively good effect, but contains chemical components, and may cause skin irritation to cause allergic reaction, and in addition, the active components may be completely released in a short time, resulting in a short sunscreen effect. At present, although a plurality of sun protection products appear on the market, the action effect is not ideal: some products show better sun protection effect, but have poorer moisturizing and moisturizing effects; some products can realize a long-time sun-proof effect when the consumption of the products is relatively large; some products have high viscosity after being used, so that the skin is greasy and thick, and the use effect is poor.
Disclosure of Invention
In view of the above, the invention provides an ultraviolet-resistant and sun-proof composition, and a preparation method and application thereof. The ultraviolet-resistant and sun-resistant composition can form a stable sun-resistant system, can keep the oil-water balance of skin, is light, thin, fresh and not greasy when in use, has the effects of moisturizing, diminishing inflammation and the like, is mild and not irritating to the skin, and has lasting effect.
The technical scheme of the invention is realized as follows:
An ultraviolet-resistant and sun-resistant composition comprises the following raw materials in parts by weight: 20-32 parts of plant extract, 7-12 parts of physical sun-screening agent, 0.1-2 parts of bisabolol, 4-8 parts of glycosyl trehalose, 4-10 parts of squalane, 0.5-2 parts of tocopheryl acetate, 3-8 parts of nicotinamide, 3-9 parts of sodium carboxymethyl dextrin, 1-4 parts of glucosamine, 1-5 parts of glycerate/acrylic acid copolymer, 0-7 parts of ferulic acid, 1-7 parts of sorbitol and 2-5 parts of glycerin.
Further, the ultraviolet-resistant and sun-resistant composition comprises the following raw materials in parts by weight: 20 parts of plant extract, 11 parts of physical sun-screening agent, 0.5 part of bisabolol, 8 parts of glycosyl trehalose, 8 parts of squalane, 1.5 parts of tocopheryl acetate, 5 parts of nicotinamide, 3 parts of sodium carboxymethyl dextrin, 3 parts of glucosamine, 2 parts of glycerylacrylate/acrylic acid copolymer, 2 parts of ferulic acid, 7 parts of sorbitol and 5 parts of glycerin.
Further, the plant extract comprises: one or more of grape seed extract, glycyrrhiza glabra root extract, tea extract, angelica sinensis root extract, imperata cylindrica root extract, and Sophora flavescens root extract.
Further, the plant extract comprises the following raw materials in parts by weight: 20-30 parts of grape seed extract, 18-22 parts of licorice root extract, 7-11 parts of tea extract, 10-15 parts of angelica root extract, 8-13 parts of cogongrass rhizome extract and 7-14 parts of kuh-seng root extract.
Further, the plant extract comprises the following raw materials in parts by weight: 25 parts of grape seed extract, 20 parts of licorice root extract, 10 parts of tea extract, 12 parts of angelica root extract, 10 parts of cogongrass rhizome extract and 12 parts of kuh-seng root extract.
Further, the physical sun-screening agent comprises one or a combination of more of nano titanium dioxide, nano silicon dioxide and nano zinc oxide.
The preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Mixing tocopheryl acetate, a physical sun-screening agent, a glycerol acrylate/acrylic acid copolymer, bisabolol and squalane under stirring to obtain a mixed material A;
(2) And (3) stirring and mixing the plant extract and the purified water at room temperature for the first time, raising the temperature, adding glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol for secondary stirring and mixing to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing again, and cooling to room temperature to obtain the ultraviolet-resistant and sun-proof composition.
Further, in the step (1), the weight of the purified water is 30-60% of that of the plant extract.
Further, the stirring and mixing speed is 400-800 r/min, the temperature is 30-60 ℃ and the time is 6-12 min.
Further, in the step (2), the primary stirring and mixing rotating speed is 200-500 r/min, and the time is 7-12 min; the secondary stirring and mixing speed is 800-1200 r/min, the temperature is 60-80 ℃ and the time is 8-14 min; the stirring and mixing speed is 400-700 r/min, the temperature is 30-50 ℃ and the time is 10-15 min.
Use of an anti-uv, sunscreen composition in a skin care product.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the plant extract and the physical sun-screening agent are used as main sun-screening substances, and the components such as bisabolol, squalane, glycosyl trehalose, tocopheryl acetate, nicotinamide, glucosamine, glycerate acrylate/acrylic acid copolymer and the like are cooperated, so that a stable sun-screening system can be formed, a good sun-screening effect can be achieved through synergy, and meanwhile, under the interaction of the components, the skin can be protected and kept against ultraviolet rays, moisture in the sun-screening composition is kept, the skin is not dried in the use process, the water-oil balance is kept, the ductility is better, and the skin is not sticky. In addition, the ultraviolet-resistant and sun-proof composition has small irritation to raw materials and high safety.
Under the synergistic effect of bisabolol, squalane, tocopheryl acetate, nicotinamide, glucosamine and the like, the invention can form a stable skin protection film, can improve the extensibility of the ultraviolet-resistant and sun-proof composition, is light, thin and thick, can help balance between skin and sebum, maintain skin moisture, reduce skin injury and the like, and has the effects of diminishing inflammation and good effect.
The invention can also improve the stability of the ultraviolet-resistant and sun-proof composition through specific process conditions, and keep the activity of the active ingredients of the composition, thereby improving the sun-proof, moisturizing and anti-inflammatory effects of the composition.
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
The plant raw materials of the invention are as follows: grape (VITISVINIFERA) seed extract, glycyrrhiza glabra (GLYCYRRHIZAGLABRA) root extract, tea (CAMELLIA SINENSIS) leaf extract, angelica sinensis (ANGELICA SINENSIS) extract, imperata cylindrica (IMPERATA CYLINDRICA) root extract, sophora flavescens (SOPHORA FLAVESCENS) root extract.
Example 1
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 32 parts of plant extract, 7 parts of physical sun-screening agent, 0.1 part of bisabolol, 4 parts of glycosyl trehalose, 10 parts of squalane, 2 parts of tocopheryl acetate, 7 parts of nicotinamide, 8 parts of sodium carboxymethyl dextrin, 2 parts of glucosamine, 5 parts of glycerate/acrylic acid copolymer, 5 parts of ferulic acid, 3 parts of sorbitol and 4 parts of glycerol; the plant extract consists of grape seed extract, licorice root extract, tea extract and kuh-seng root extract according to the mass ratio of 2:2:1:1; the physical sun-screening agent consists of nano titanium dioxide and nano silicon dioxide according to the mass ratio of 1:1;
the preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Mixing tocopheryl acetate, physical sun-screening agent, glycerol acrylate/acrylic acid copolymer, bisabolol and squalane at 800r/min and 50deg.C under stirring for 10min to obtain mixed material A;
(2) Stirring and mixing the plant extract and 30% of purified water by weight of the plant extract for 12min at the room temperature of 300r/min, raising the temperature to 60 ℃, adding glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol, stirring and mixing for 12min at the temperature of 60 ℃ at the speed of 1200r/min to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing for 11min again at the temperature of 50 ℃ at the speed of 600r/min, and cooling to the room temperature to obtain the ultraviolet-resistant and sun-screening composition.
Example 2
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 28 parts of plant extract, 12 parts of physical sun-screening agent, 1 part of bisabolol, 5 parts of glycosyl trehalose, 4 parts of squalane, 1 part of tocopheryl acetate, 3 parts of nicotinamide, 9 parts of sodium carboxymethyl dextrin, 1 part of glucosamine, 1 part of glycerylacrylate/acrylic acid copolymer, 7 parts of ferulic acid, 5 parts of sorbitol and 3 parts of glycerol; the plant extract consists of grape seed extract, licorice root extract, angelica root extract and cogongrass rhizome extract according to the mass ratio of 1:3:1:1; the physical sun-screening agent comprises nano titanium dioxide, nano silicon dioxide and nano zinc oxide according to the mass ratio of 2:1:1;
the preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Mixing tocopheryl acetate, physical sun-screening agent, glycerol acrylate/acrylic acid copolymer, bisabolol and squalane at rotation speed of 400r/min and temperature of 30deg.C under stirring for 6min to obtain mixed material A;
(2) Stirring and mixing the plant extract and 50% of purified water by weight of the plant extract for 9min at the room temperature of 200r/min, raising the temperature to 70 ℃, adding glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol, stirring and mixing for two times at the temperature of 70 ℃ for 14min at the speed of 1000r/min to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing for 15min again at the speed of 700r/min at the temperature of 30 ℃, and cooling to the room temperature to obtain the ultraviolet-resistant and sun-screening composition.
Example 3
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 25 parts of plant extract, 10 parts of physical sun-screening agent, 2 parts of bisabolol, 6 parts of glycosyl trehalose, 6 parts of squalane, 0.5 part of tocopheryl acetate, 8 parts of nicotinamide, 5 parts of sodium carboxymethyl dextrin, 4 parts of glucosamine, 4 parts of glycerate/acrylic acid copolymer, 0 part of ferulic acid, 1 part of sorbitol and 2 parts of glycerol; the plant extract consists of tea extract, angelica root extract, cogongrass rhizome extract and kuh-seng root extract according to the mass ratio of 2:2:1:1; the physical sun-screening agent consists of nano silicon dioxide and nano zinc oxide according to the mass ratio of 1:1;
the preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Mixing tocopheryl acetate, physical sun-screening agent, glycerol acrylate/acrylic acid copolymer, bisabolol and squalane at rotation speed of 600r/min and temperature of 40deg.C for 8min to obtain mixed material A;
(2) Stirring and mixing the plant extract and 60% of purified water by weight of the plant extract for 10min at the room temperature of 500r/min, then raising the temperature to 80 ℃, adding glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol, stirring and mixing for 10min at the temperature of 80 ℃ at the speed of 900r/min to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing for 10min again at the temperature of 40 ℃ at the speed of 500r/min, and cooling to the room temperature to obtain the ultraviolet-resistant and sun-screening composition.
Example 4
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 20 parts of plant extract, 11 parts of physical sun-screening agent, 0.5 part of bisabolol, 8 parts of glycosyl trehalose, 8 parts of squalane, 1.5 parts of tocopheryl acetate, 5 parts of nicotinamide, 3 parts of sodium carboxymethyl dextrin, 3 parts of glucosamine, 2 parts of glycerylacrylate/acrylic acid copolymer, 2 parts of ferulic acid, 7 parts of sorbitol and 5 parts of glycerol; the plant extract comprises the following raw materials in parts by weight: 25 parts of grape seed extract, 20 parts of licorice root extract, 10 parts of tea extract, 12 parts of angelica root extract, 10 parts of cogongrass rhizome extract and 12 parts of radix sophorae flavescentis root extract; the physical sun-screening agent consists of nano titanium dioxide and nano zinc oxide according to the mass ratio of 2:1;
the preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Mixing tocopheryl acetate, physical sun-screening agent, glycerol acrylate/acrylic acid copolymer, bisabolol and squalane at rotation speed of 500r/min and temperature of 60deg.C under stirring for 12min to obtain mixed material A;
(2) Stirring and mixing the plant extract and 40% of purified water by weight of the plant extract for 7min at the room temperature of 400r/min, then raising the temperature to 60 ℃, adding glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol, stirring and mixing for 8min at the temperature of 60 ℃ at the speed of 800r/min to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing for 12min again at the temperature of 50 ℃ at the speed of 400r/min, and cooling to the room temperature to obtain the ultraviolet-resistant and sun-screening composition.
Comparative example 1
The comparative example is different in the raw material ratio of the ultraviolet-resistant and sun-screening composition as compared with example 4.
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 10 parts of plant extract, 18 parts of physical sun-screening agent, 3 parts of bisabolol, 15 parts of glycosyl trehalose, 12 parts of squalane, 4 parts of tocopheryl acetate, 1 part of nicotinamide, 1 part of sodium carboxymethyl dextrin, 6 parts of glucosamine, 7 parts of glycerylacrylate/acrylic acid copolymer, 8 parts of ferulic acid, 1 part of sorbitol and 8 parts of glycerol; the plant extract comprises the following raw materials in parts by weight: 10 parts of grape seed extract, 10 parts of licorice root extract, 30 parts of tea extract, 5 parts of angelica root extract, 18 parts of cogongrass rhizome extract and 6 parts of kuh-seng root extract; the physical sun-screening agent consists of nano titanium dioxide and nano zinc oxide according to the mass ratio of 2:1;
Comparative example 2
This comparative example does not contain a plant extract as compared with example 4.
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 11 parts of physical sun-screening agent, 0.5 part of bisabolol, 8 parts of glycosyl trehalose, 8 parts of squalane, 1.5 parts of tocopheryl acetate, 5 parts of nicotinamide, 3 parts of sodium carboxymethyl dextrin, 3 parts of glucosamine, 2 parts of glycerol acrylate/acrylic acid copolymer, 2 parts of ferulic acid, 7 parts of sorbitol and 5 parts of glycerol; the physical sun-screening agent consists of nano titanium dioxide and nano zinc oxide according to the mass ratio of 2:1;
the preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Mixing tocopheryl acetate, physical sun-screening agent, glycerol acrylate/acrylic acid copolymer, bisabolol and squalane at rotation speed of 500r/min and temperature of 60deg.C under stirring for 12min to obtain mixed material A;
(2) Mixing glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol, adding 40% of purified water by weight of the mixture, stirring and mixing for 8min at the temperature of 60 ℃ at the speed of 800r/min to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing again for 12min at the temperature of 50 ℃ at the speed of 400r/min, and cooling to room temperature to obtain the ultraviolet-resistant and sun-resistant composition.
Comparative example 3
This comparative example does not contain bisabolol and squalane as compared with example 4.
The ultraviolet-resistant and sun-proof composition comprises the following raw materials in parts by weight: 20 parts of plant extract, 11 parts of physical sun-screening agent, 8 parts of glycosyl trehalose, 1.5 parts of tocopheryl acetate, 5 parts of nicotinamide, 3 parts of sodium carboxymethyl dextrin, 3 parts of glucosamine, 2 parts of glycerol acrylate/acrylic acid copolymer, 2 parts of ferulic acid, 7 parts of sorbitol and 5 parts of glycerol; the plant extract comprises the following raw materials in parts by weight: 25 parts of grape seed extract, 20 parts of licorice root extract, 10 parts of tea extract, 12 parts of angelica root extract, 10 parts of cogongrass rhizome extract and 12 parts of radix sophorae flavescentis root extract; the physical sun-screening agent consists of nano titanium dioxide and nano zinc oxide according to the mass ratio of 2:1;
the preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
(1) Stirring and mixing tocopheryl acetate, a physical sun-screening agent and a glycerol acrylic ester/acrylic acid copolymer for 12min at the temperature of 60 ℃ at the rotating speed of 500r/min to obtain a mixed material A;
(2) Stirring and mixing the plant extract and 40% of purified water by weight of the plant extract for 7min at the room temperature of 400r/min, then raising the temperature to 60 ℃, adding glycosyl trehalose, nicotinamide, sodium carboxymethyl dextrin, glucosamine, ferulic acid and sorbitol, stirring and mixing for 8min at the temperature of 60 ℃ at the speed of 800r/min to obtain a mixed material B, adding the mixed material A obtained in the step (1), stirring and mixing for 12min again at the temperature of 50 ℃ at the speed of 400r/min, and cooling to the room temperature to obtain the ultraviolet-resistant and sun-screening composition.
Comparative example 4
This comparative example is not identical to example 4 in preparation.
The preparation method of the ultraviolet-resistant and sun-resistant composition comprises the following steps:
Stirring and mixing the plant extract and 40% of purified water by weight thereof for 7min at the rotating speed of 400r/min, then raising the temperature to 60 ℃, adding physical sun-screening agent, bisabolol, glycosyl trehalose, squalane, tocopherol acetate, nicotinamide, sodium carboxymethyl dextrin, glucosamine, glycerate/acrylic acid copolymer, ferulic acid, sorbitol, glycerol and the mixture A obtained in the step (1), stirring and mixing for 15min at the rotating speed of 800r/min and the temperature of 60 ℃ for the second time, and cooling to the room temperature to obtain the ultraviolet-resistant and sun-screening composition.
Test conditions
The ultraviolet-resistant and sun-resistant compositions prepared in examples 1 to 4 and comparative examples 1 to 4 were used as test samples for performance experiments. The experimental conditions are as follows.
1. Stability test
Respectively taking 20g of each group of test samples, putting the test samples into a glass bottle, covering a bottle cap, and then respectively observing the split phase condition of each group of test samples at-15 ℃ and 49 ℃ for 60 days; then, the same amount of each group of test samples is taken and centrifuged at 2000r/min for 30min, and the layering condition of the test samples is observed.
TABLE 1 stability test results
As can be seen from Table 1, the UV-resistant and sun-screening compositions of examples 1 to 4 were not subjected to oil-water separation or delamination after being left at-15℃and 49℃for 60 days, and were also not subjected to delamination after being rapidly centrifuged, which indicates that the UV-resistant and sun-screening composition of the present invention was able to have higher stability by reasonable raw material ratios and specific preparation processes. The raw materials of comparative example 1 are different in proportion, and the preparation modes of comparative example 4 are different, so that the stability of the ultraviolet-resistant and sun-proof composition is reduced. Comparative example 2, which does not contain a plant extract, comparative example 3, which does not contain bisabolol and squalane, has less effect on the stability of the ultraviolet light resistant and sun screening composition.
2. Sun protection experiment
The experimental samples of inventive examples 1-4 and comparative examples 1-4 were subjected to sunscreen experiments according to the cosmetic safety technical Specification. Accurately weighing a test sample, uniformly smearing the test sample on a sample plate, naturally drying the sample in a shady place for 30min, then measuring UVA and UVB sun protection values by adopting a sun protection index testing instrument, and finally respectively using PA and SPF values to represent an experiment result, wherein the method for representing the protection grade PA comprises the following steps: PFA is more than or equal to 2 and less than 4 and is PA+; PFA <8 > is PA++ with the value of 4 or less; PFA is 8-16 and is PA++; PFA >16 is pa+ + with ++, of the material. As shown in table 2 below.
TABLE 2 Sun protection experimental conditions
| Group of | SPF value | PFA value | PA grade |
| Example 1 | 48.7 | 18.2 | PA++++ |
| Example 2 | 49.3 | 19.0 | PA++++ |
| Example 3 | 50.5 | 19.5 | PA++++ |
| Example 4 | 51.0 | 20.3 | PA++++ |
| Comparative example 1 | 45.2 | 14.8 | PA+++ |
| Comparative example 2 | 41.5 | 13.5 | PA+++ |
| Comparative example 3 | 47.9 | 17.4 | PA++++ |
| Comparative example 4 | 43.6 | 15.3 | PA+++ |
As can be seen from Table 2, the ultraviolet-resistant and sun-screening compositions prepared in examples 1-4 of the invention have the advantages of synergistic interaction, good sun-screening effect, best scheme in example 4 and best sun-screening effect. The proportion of the raw materials of the ultraviolet-resistant and sun-proof composition in comparative example 1 is not in the specific range of the invention, and the sun-proof effect is reduced; comparative example 2 does not contain a plant extract, loses the sun-screening component in the plant extract, and has a significantly reduced sun-screening effect; comparative example 3, which does not contain bisabolol and squalane, has less influence on the sunscreen effect; the preparation method of comparative example 4 is different, and may be due to poor stability of the ultraviolet-resistant and sun-screening composition, so that the sun-screening effect is obviously reduced due to failure of the sun-screening active ingredients.
3. Skin irritation test
The test samples prepared in examples 1 to 4 and comparative examples 1 to 4 were subjected to skin irritation experiments. Healthy white guinea pigs were selected in 48 groups of 6 randomly. Before the experiment starts, the hairs of the same area on the left side and the right side of the back vertebra of the guinea pig are cut off to serve as an experiment area, the area of the left area and the right area is 2 multiplied by 3cm, in the experiment process, 0.5ml of each group of experiment samples are respectively coated on the left experiment area of the guinea pig, no treatment is carried out on the right experiment area to serve as a blank control, and the experiment area is continuously coated for 7 days. The hair shearing treatment is carried out before the application, residual test substances are removed by water or non-irritating solvents, whether erythema and edema are caused or not is observed after 1 hour, the observation and scoring are carried out after the application according to the scoring standard of the table, the total score of each group of erythema and edema is counted, and the irritation evaluation is carried out according to the integral mean value.
TABLE 3 skin irritation response score
TABLE 4 skin irritation test
As is clear from Table 4, the ultraviolet-resistant and sun-screening compositions of examples 1 to 4 and comparative examples 1 to 4 showed no irritation reaction to guinea pig skin, and had good safety, indicating that the raw materials used in the invention had low irritation and high safety.
4. Evaluation of skin feel
80 Healthy volunteers were selected, randomly divided into 8 groups of 10 persons each, and skin feel experiments were conducted using the ultraviolet resistant and sun screening compositions prepared in examples 1 to 4 and comparative examples 1 to 4, respectively, as test samples. The face is cleaned before the test sample is used, then the same amount of test sample is taken to be smeared on the face once a day, the test sample is continuously used for 7 days, no other cosmetics are used during the test, after the test is used for 7 days, comprehensive scoring is carried out according to the daily use condition and the scoring standard, the total score is 20, the scoring condition is counted, the result is averaged, and the result is shown in the following table.
TABLE 5 skin feel scoring criteria
TABLE 6 evaluation of skin feel
| Average score of sun protection effect | Average score of skin feel index | |
| Example 1 | 9.2 | 9.3 |
| Example 2 | 9.4 | 9.5 |
| Example 3 | 9.5 | 9.6 |
| Example 4 | 9.7 | 9.7 |
| Comparative example 1 | 8.1 | 7.6 |
| Comparative example 2 | 7.6 | 7.0 |
| Comparative example 3 | 8.8 | 7.3 |
| Comparative example 4 | 7.9 | 7.4 |
As can be seen from Table 6, the ultraviolet-resistant and sun-resistant compositions prepared in examples 1 to 4 of the invention have good sun-resistant effects, are easy to spread and extend in the use process, are not thick, are fresh and not greasy, and can keep the oil-water balance of skin; the raw materials in the comparative example 1 are not scientific and reasonable in proportion, so that the sun-screening effect and the skin feel experience effect are poor, and the skin feel effect is slightly sticky and has the oil outlet condition; the comparative example 2 does not contain plant extracts, so that the sun-proof effect is reduced, the ultraviolet-resistant sun-proof composition is thicker, lighter, less sticky and slightly greasy, and the extensibility is poor; the comparative example 3, which does not contain bisabolol and squalane, has a major effect on skin feel, so that the ultraviolet-resistant and sun-screening composition has poor ductility; the preparation modes of comparative example 4 are different, so that the stability of the composition is slightly poor, and the sun-screening effect and the skin feel experience are affected.
The result shows that the ultraviolet-resistant and sun-resistant composition can form a stable sun-resistant system, can keep the oil-water balance of skin, is light, thin, fresh and not greasy when in use, has the effects of moisturizing, diminishing inflammation and the like, is mild and not irritating to the skin, and has lasting effect.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
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