CN117695202A - Probiotic metazoan composition for improving scalp environment and preparation method and application thereof - Google Patents

Abstract

The invention discloses a probiotic metagen composition for improving scalp environment, a preparation method and application thereof, wherein the probiotic metagen composition for improving scalp environment comprises metagen obtained by fermenting two strains of lactobacillus paracasei ProSci-101 and lactobacillus fermentum ProSci-602; the collection number of the lactobacillus paracasei ProSci-101 is CGMCC No.26528; the lactobacillus fermentum ProSci-602 has a preservation number of CGMCC NO.25451. The probiotic metazoan composition for improving scalp environment has the effects of repairing cells, improving elastin and renewing metabolism of dermis, can slow down cell aging and promote proliferation of keratinocytes; thereby effectively achieving the aims of improving scalp environment and preventing alopecia.

Description

Probiotic postbiotic composition for improving scalp environment and preparation method and application thereof

Technical field

The present invention relates to the technical field of cleansing and care products, and in particular to a probiotic postbiotic composition that improves the scalp environment and its preparation method and application.

Background technique

The skin is like the human body's barrier. It is soft, tough, and elastic. It protects the tissues and organs in the body from damage by various harmful factors in the external environment. It also has natural moisturizing properties. However, as age increases, the skin's water-holding capacity also weakens. Due to climate changes, seasonal changes, and bad living habits, the skin is dehydrated and dry, dandruff appears, and the stratum corneum is damaged. As for the scalp, most adults have varying degrees of problems such as oily scalp, itchy scalp, and dandruff, and some even suffer from severe hair loss; therefore, it is necessary to repair the scalp environment.

Scalp microecology is currently a hot research topic in scalp health, and research on preventing and treating scalp diseases by regulating microecological balance is becoming more and more in-depth. Existing research has found that when the ecological balance of the scalp is disrupted, it will irritate the scalp and cause scalp diseases such as acne and dermatitis.

Postbiotics, as bacterial components or microbial metabolites of biologically active microorganisms, have been proven to be rich in a variety of organic acids, antibacterial peptides, bacteriocins, short-chain fatty acids and other biologically active substances. A large number of experiments have proven that postbiotics play an important role in immune balance, Digestive health and skin care areas play an important role. The use of postbiotics avoids the problems of low bioavailability and unstable effects of probiotics. However, postbiotic solutions produced by fermentation and metabolism of various probiotics disclosed in the prior art can improve the scalp cell environment when added and used. , promoting cell metabolism and circulation is not significant. It usually needs to be combined with other plant extracts with scalp care effects to effectively achieve the effects of improving the skin environment and replenishing moisture.

Contents of the invention

Therefore, the technical problem to be solved by the present invention is to overcome the shortcomings disclosed in the prior art that simply adding probiotic postbiotic compositions cannot significantly improve the scalp environment and prevent hair loss, thereby providing a method that can significantly improve the scalp environment when added alone. A probiotic postbiotic composition for environment and hair loss prevention, and a preparation method and application of the probiotic postbiotic composition are provided.

A probiotic postbiotic composition that improves the scalp environment, characterized by including postbiotics fermented by two strains of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602;

The Lactobacillus paracasei ProSci-101 has a deposit number of CGMCC No. 26528 and is recorded in the patent application text with publication number CN116555112A.

The Lactobacillus fermentum ProSci-602 has a deposit number of CGMCC NO.25451 and is recorded in the patent application text with publication number CN115624517A.

The above-mentioned Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602 are both published strains, and the preservation information will not be described again.

The postbiotic component is a mixture containing metabolites and is rich in biologically active substances such as a variety of organic acids, antimicrobial peptides, bacteriocins, short-chain fatty acids, etc.

The postbiotics include antibacterial substances, active substances and short-chain fatty acids.

In the postbiotic, the antibacterial substance is an organic acid component; preferably, the organic acid component includes lactic acid 10-45 mg/g, citric acid 100-200 mg/g, oxalic acid 1.0-2.3 mg/g, and malic acid 0.5 -3.0mg/g, phenyllactic acid 0.75-3.25mg/g, succinic acid 0.3-3.5mg/g, 4-hydroxyphenyllactic acid 0.2-3.8mg/g, phenylalanine 0.03-2.9mg/g.

More preferably, the organic acids also include salicylic acid 0.01-1.0 mg/g, vanillic acid 0.01-0.8 mg/g, benzoic acid 3-17 mg/g, and tartaric acid 0.01-1.2 mg/g.

And/or, in the postbiotics, the active substances include lauryl diethanolamine 1-5 mg/g, soy saponin 0.2-0.9 mg/g, soy isoflavones 0.05-2.25 mg/g, and γ-aminobutyric acid 0.1 -3.6mg/g, malonylgenistein 0.05-1.75mg/g, D-psicose 0.03-1.75mg/g, 3-indoleacrylic acid 0.01-0.5mg/g, genistein 0.01-0.5 mg/g, malonyl daidzein-0.03-0.5mg/g, irisone 0.5-3.5mg/g, Preaustinoid A0.2-1.6mg/g, hyaluronic acid 0.02-1.85mg/g, extracellular polysaccharide 0.1 -5.0 mg/g, polypeptide 0.2-5.0 mg/g; preferably, the active substances also include isostearic acid 0.08-2.0 mg/g, trihydroxyflavone 0.02-2.5 mg/g, and daidzein 0.01-2.4 mg/g, butyrin 0.05-3.6 mg/g.

And/or, in the postbiotic, the short-chain fatty acids include acetic acid 10-80 mg/g, propionic acid 3-25 mg/g, butyric acid 0.05-10 mg/g, valeric acid 0.01-5 mg/g, and caproic acid 0.5 -12.0mg/g.

The contents of specific components in the above-mentioned antibacterial substances, active substances and short-chain fatty acids are based on the mass of postbiotics.

The probiotic postbiotic composition for improving the scalp environment not only includes postbiotics, but also includes 11-16% moisturizer, 4-9% oil, 4-7% skin conditioner, and 0.8-1.6% emulsifier. , of which postbiotics are 1.5-4.0%, and the balance is deionized water.

If the added amount of postbiotic ingredients is less than 1.5%, the compound use effect will not be obvious and cannot be completely integrated with other components; if the added amount of postbiotic ingredients is greater than 4%, its compound use will have a good effect on improving the scalp. Environment, anti-hair loss effect. Meanwhile, in hair lotions, postbiotic ingredients also act as moisturizers and skin conditioners.

The moisturizing agent is at least one of glycerol, butylene glycol, allantoin, betaine, hydrolyzed sodium hyaluronate, gluconolactone, 1,3-propanediol and panthenol; further preferably, the The moisturizing agent is one or more of glycerin, butylene glycol, betaine, and hydrolyzed sodium hyaluronate.

Betaine has a strong hydrating effect. When applied to the skin surface, it can achieve the effect of hydrating and moisturizing, keeping the skin moist for a long time. It can also regulate the osmotic pressure of the scalp, promote the synthesis of proteins in cells, and improve the cell density of scalp hair follicles. vitality.

And/or, the oil is at least one of squalane, jojoba oil, shea butter, borage oil, almond oil and linseed oil; further preferably, the oil is squalane, One or more of jojoba oil and flaxseed oil.

Squalane has ultra-high affinity and is the lipid closest to human sebum. When used on the skin, it can form a natural protective film for the skin. It also has good permeability and can reach the dermis layer through the skin, which can promote the renewal and proliferation of basal cells, repair damaged cells at the same time, delay the aging of cells, improve and enhance the ability of cells to retain water, and "treat both the symptoms and root causes" of the scalp. environment, enhance hair follicle growth;

Flaxseed oil contains a variety of unsaturated fatty acids and high-quality natural vitamin E and vitamin K, which has good penetration and affinity for the skin. When flaxseed oil enters the dermis layer of the skin, the fatty acids in it can be absorbed by the skin as nutrients, supplementing the lipid substances needed by the scalp to repair damaged stratum corneum. Flaxseed oil also forms a water-retaining film on the surface of the scalp, preventing deep moisture loss and dryness within the skin.

And/or, the skin conditioner is at least one of p-hydroxyacetophenone, retinol, calendula extract, resurrection grass extract, pomegranate extract, and Atractylodes algae extract; further preferably , the skin conditioning agent includes retinol, calendula extract, and resurrection grass extract.

Retinol is a type of fat-soluble vitamin, namely vitamin A, which has a good protective effect on the scalp, promotes skin metabolism, accelerates skin keratinization, and prevents scalp dehydration and dryness and abnormal keratin metabolism. It also has the effect of antioxidant and promoting collagen regeneration, keeping the skin soft and plump, fundamentally strengthening the scalp's water-locking ability, and preventing scalp dryness and aging;

Calendula extract can quickly activate dormant fibroblasts, promote cell division and self-repair and renewal, secrete collagen substances, enhance skin elasticity, regenerate skin cells continuously, give the skin sufficient moisture and super water-locking ability, and promote cell growth at the same time. Self-repair to achieve a better effect of improving the head environment;

Resurrection grass extract is rich in a large amount of glycosyl trehalose. This small molecule substance enters the skin base and replenishes cells with a large amount of water, rejuvenating basal cells and making cells youthful.

And/or, the emulsifier is oleth-10, PEG-100 stearate, PEG-10 polydimethylsiloxane, glyceryl oleate, polyglyceryl-6 polyricinoleate , at least one of cetearyl glucoside, sodium stearoyl lactylate, and sodium stearoyl glutamate.

In the probiotic postbiotic composition of the present invention, the oil and fat constitute the oil phase A, and the postbiotic and other components other than the oil and fat constitute the water phase B.

Further, the oil phase A includes squalane, jojoba oil and flaxseed oil; the water phase B includes glycerin, butylene glycol, betaine, retinol, hydrolyzed sodium hyaluronate, calendula extract, resurrection grass extract, emulsifier and deionized water.

The preparation method of a probiotic postbiotic composition that improves the scalp environment includes: mixing other ingredients in the probiotic postbiotic composition except for postbiotics evenly to obtain a mixture and sterilizing it, and then adding the postbiotics to a temperature lowered to 42 -50°C mixture, mix evenly.

Wherein, the preparation process of the mixture is:

Heat the oil to 80-85°C and stir evenly until it is completely dissolved and transparent to obtain oil phase A;

Mix oil and other raw materials other than postbiotics, heat to 75-85°C and stir evenly until completely dissolved to obtain water phase B;

Mix the oil phase A and the water phase B, and continue stirring until the mixture is uniform, and control the temperature at 75-80°C;

Mix evenly to obtain a mixture;

The mixture was then sterilized at 75-80°C for 30 minutes.

The present invention also discloses the use of a probiotic postbiotic composition that improves the scalp environment in improving the scalp environment and preventing hair loss; preferably, the product is a shampoo, conditioner, cream hair mask or hair care essential oil Class cleansing and care products; the content of postbiotics in the products is 1.5-4.0%.

The technical solution of the present invention has the following advantages:

1. The probiotic postbiotic composition provided by the present invention for improving the scalp environment, when added to the care product, can restore the moisturizing ability of the scalp and achieve better effects of improving the scalp environment and preventing hair loss; specifically, the present invention The postbiotic ingredients selected in the invention include Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602. They also contain a variety of antibacterial substances and active ingredients, which can repair cells, increase elastin and renew the metabolism of the dermis, and can slow down the metabolism of the dermis. Cell senescence promotes the proliferation of cuticle cells; the postbiotics in the present invention are obtained by fermentation of two strains of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602, which are similar in composition to postbiotics obtained by fermentation of a single strain. Compared with this product, it has better hydrating, moisturizing, hair growth and anti-hair loss effects, and can solve more scalp health problems caused by imbalance of scalp microecology.

2. The probiotic postbiotic composition provided by the present invention for improving the scalp environment can also be compounded with a variety of other ingredients with various functions such as moisturizing, anti-allergic, repairing, etc., to achieve the purpose of mutual synergy; in particular, the present invention The invention uses a combination of calendula extract, resurrection grass extract and postbiotics, which can play a synergistic and promoting role. Through the compound use of multiple ingredients, the bioavailability of postbiotic ingredients is improved, which better improves the scalp environment.

Detailed ways

The following examples are provided to better understand the present invention. They are not limited to the best embodiments and do not limit the content and protection scope of the present invention. Anyone who is inspired by the present invention or uses the present invention to Any product that is identical or similar to the present invention by combining it with other features of the prior art falls within the protection scope of the present invention.

If no specific experimental steps or conditions are specified in the examples, the procedures can be carried out according to the conventional experimental steps or conditions described in literature in the field. If the manufacturer of the reagents or instruments used is not indicated, they are all conventional reagent products that can be purchased commercially.

Among them, the preparation process of postbiotics obtained by fermentation of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602 is as follows:

Seed culture: Take 0.1 mL of Lactobacillus paracasei ProSci-101 bacterial liquid and inoculate it into MRS liquid culture medium (purchased from Beijing Luqiao Technology Co., Ltd.) and culture it at 30°C for 30 hours to obtain ProSci-101 seed liquid; take 0.1 mL of Lactobacillus fermentum ProSci-602 bacterial liquid was inoculated into MRS liquid culture medium, and cultured at 30°C for 30 hours to obtain ProSci-602 seed liquid;

Fermentation: Inoculate ProSci-101 seed liquid and ProSci-602 seed liquid into the fermentation medium until the total viable count of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602 is 2×106CFU/ After mL, culture it at 30°C for 30 hours to obtain the fermentation broth; during inoculation, the viable bacterial ratio of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602 is 1:1;

Post-processing: Sterilize and inactivate the fermentation broth at 85°C for 15 minutes to obtain a sterilized and inactivated fermentation broth; spray-dry the sterilized and inactivated fermentation broth to obtain postbiotics (in postbiotics, Lactobacillus paracasei ProSci-101 The total number of cells of Lactobacillus fermentum ProSci-602 is 2.0×1011/g);

Wherein, the preparation method of fermentation medium is as follows:

In terms of mass percentage, the components of the fermentation medium are composed of 1% skimmed soybean powder, 8% skimmed milk powder and the balance water; after mixing the components of the fermentation medium in proportion, the material is mixed at 58°C (that is, stirred at 150 rpm) After 15 minutes, the material liquid is obtained; homogenize the material liquid once at 58°C at a primary pressure of 19Mpa and a secondary pressure of 5.0Mpa to obtain a homogenized material liquid; sterilize the homogenized material liquid at 93°C for 30 minutes , to obtain a sterilized feed liquid; cool the sterilized feed liquid to 35°C to obtain a fermentation medium.

After testing, the postbiotics prepared by the above method include lactic acid 22.2mg/g, citric acid 155.03mg/g, oxalic acid 1.44mg/g, malic acid 1.85mg/g, phenyllactic acid 1.45mg/g, and succinic acid 1.65mg /g, 4-hydroxyphenyllactic acid 1.03mg/g, phenylalanine 0.38mg/g, salicylic acid 0.075mg/g, vanillic acid 0.053mg/g, benzoic acid 7.2mg/g, tartaric acid 0.055mg/g, Lauryl diethanolamine 3.03mg/g, soybean saponin 0.447mg/g, soybean isoflavones 0.282mg/g, γ-aminobutyric acid 0.438mg/g, malonylgenistin 0.265mg/g, D-alloxone Sugar 0.241mg/g, 3-indoleacrylic acid 0.231mg/g, genistein 0.226mg/g, malonyl daidzein 0.212mg/g, irisone 1.124mg/g, Preaustinoid A 0.481mg/g, hyaluronic acid Acid 0.065mg/g, extracellular polysaccharide 0.303mg/g, polypeptide 0.576mg/g, isostearic acid 0.316mg/g, trihydroxyflavone 0.298mg/g, daidzein 0.283mg/g, butyrin 0.261 mg/g, acetic acid 32.82mg/g, propionic acid 8.68mg/g, butyric acid 2.14mg/g, valeric acid 1.21mg/g, caproic acid 4.69mg/g.

Example 1

The probiotic postbiotic composition that improves the scalp environment is also a hair care lotion. Its specific composition is as follows:

Postbiotics: 1.5%;

Moisturizer: glycerin 3%, butylene glycol 4%, betaine 2%, hydrolyzed sodium hyaluronate 2%;

Oils and fats: 1% squalane, 0.8% jojoba oil, 2% linseed oil;

Skin conditioners: Retinol 3%, calendula extract 0.5%, resurrection grass extract 0.4%;

Emulsifier: 0.8%;

The balance is deionized water.

The preparation method of the above probiotic postbiotic composition is:

(1) Mix squalane, jojoba oil and linseed oil in oil phase A, heat to 82°C and stir evenly until completely dissolved and transparent;

(2) Mix the glycerin, butylene glycol, betaine, retinol, hydrolyzed sodium hyaluronate, calendula extract, resurrection grass extract, emulsifier and deionized water in water phase B, and heat to 80 ℃ and stir evenly until completely dissolved;

(3) Mix the oil phase A and the water phase B, and continue stirring until the mixture is uniform, and control the temperature at 78°C;

(4) Mix evenly and keep warm for 30 minutes for sterilization, then turn on the cooling water to cool down. The cooling water temperature is 25°C;

(5) When the temperature is lowered to 45°C, add postbiotics and stir evenly;

(6) Continue to cool to 32°C, discharge the material, and complete the preparation of hair care solution.

Example 2

The probiotic postbiotic composition that improves the scalp environment is also a hair care lotion. Its specific composition is as follows:

Postbiotics: 2.5%;

Moisturizer: 4% glycerin, 3.5% butylene glycol, 3% betaine, 2% hydrolyzed sodium hyaluronate;

Oils and fats: 1% squalane, 0.8% jojoba oil, 2% linseed oil;

Skin conditioners: retinol 5%, calendula extract 0.5%, resurrection grass extract 0.7%;

Emulsifier: 0.8%;

The balance is deionized water.

The preparation method of the above probiotic postbiotic composition is:

(1) Mix squalane, jojoba oil and linseed oil in oil phase A, heat to 82°C and stir evenly until completely dissolved and transparent;

(2) Mix the glycerin, butylene glycol, betaine, retinol, hydrolyzed sodium hyaluronate, calendula extract, resurrection grass extract, emulsifier and deionized water in water phase B, and heat to 80 ℃ and stir evenly until completely dissolved;

(3) Mix the oil phase A and the water phase B, and continue stirring until the mixture is uniform, and control the temperature at 78°C;

(4) Mix evenly and keep warm for 30 minutes for sterilization, then turn on the cooling water to cool down. The cooling water temperature is 25°C;

(5) When the temperature is lowered to 45°C, add postbiotics and stir evenly;

(6) Continue to cool to 32°C, discharge the material, and complete the preparation of hair care solution.

Example 3

The probiotic postbiotic composition that improves the scalp environment is also a hair care lotion. Its specific composition is as follows:

Postbiotics: 4%;

Moisturizer: glycerin 4%, butylene glycol 5%, betaine 3.5%, hydrolyzed sodium hyaluronate 3%;

Oils and fats: 3% squalane, 2% jojoba oil, 4% linseed oil;

Skin conditioners: retinol 5%, calendula extract 0.8%, resurrection grass extract 0.4%;

Emulsifier: 1.6%;

The balance is deionized water.

The preparation method of the above probiotic postbiotic composition is:

(1) Mix squalane, jojoba oil and linseed oil in oil phase A, heat to 82°C and stir evenly until completely dissolved and transparent;

(2) Mix the glycerin, butylene glycol, betaine, retinol, hydrolyzed sodium hyaluronate, calendula extract, resurrection grass extract, emulsifier and deionized water in water phase B, and heat to 80 ℃ and stir evenly until completely dissolved;

(3) Mix the oil phase A and the water phase B, and continue stirring until the mixture is uniform, and control the temperature at 78°C;

(4) Mix evenly and keep warm for 30 minutes for sterilization, then turn on the cooling water to cool down. The cooling water temperature is 25°C;

(5) When the temperature is lowered to 45°C, add postbiotics and stir evenly;

(6) Continue to cool to 32°C, discharge the material, and complete the preparation of hair care solution.

Example 4

A shampoo, containing 96% of a commercially available brand of shampoo with no anti-hair loss effect, 4% of a probiotic postbiotic composition that improves the scalp environment, and the probiotic postbiotic composition that improves the scalp environment only contains the present invention Postbiotics in .

The specific preparation method includes: heating the shampoo without anti-hair loss effect to 45°C, adding postbiotics, and stirring evenly.

Example 5

The only difference between this comparative example and Example 1 is that the skin conditioning agents in the probiotic postbiotic composition that improves the scalp environment are replaced with: 3% retinol and 1.2% calendula extract.

Example 6

The only difference between this comparative example and Example 1 is that the skin conditioning agents in the probiotic postbiotic composition that improves the scalp environment are replaced with: 3% retinol and 1.2% resurrection grass extract.

Comparative example 1

The only difference between this comparative example and Example 1 is that no postbiotics are added to the probiotic postbiotic composition for improving the scalp environment.

Comparative example 2

The only difference between this comparative example and Example 4 is that postbiotics are not added to the shampoo.

Experimental example

Test method: A total of 128 volunteers aged 25-55 years old were selected and randomly divided into 8 groups, with 16 people in each group, 8 men and women. The same group of volunteers used the same product of the embodiment or comparative example.

Six groups of volunteers took 2 ml of the hair care solution of Examples 1-3, 5-6 and Comparative Example 1 and applied it to their scalp every morning and evening, and massaged for 3-5 minutes until completely absorbed. The remaining two groups of volunteers took 2 ml of the shampoo of Example 4 and Comparative Example 1 and applied it to the scalp every day, massaged for 3-5 minutes, and then washed.

Comb the hair every two weeks, collect the fallen hair and count it, and use a micro camera to record the hair growth, that is, evaluate the hair density, and finally get the average integer value of each group. The test results are shown in Table 1. The skin moisture tester Corneometer CM825 was used to test the moisture content of the scalp cuticle, and the Tewameter TM300 instrument was used to measure the transepidermal water loss rate. The measurements were made three times and the average value was taken. The test sites were all on the top of the head. The test results are shown in Table 2.

Sit quietly for 30 minutes in an indoor environment at 20°C and 50% relative humidity. Before applying, use a probe to test the scalp moisture content and water loss rate in the test area on the top of your head. Measure three times, and finally take the average of all data as the data before application; Take the composition sample of the example or comparative example and apply it to the test area. The amount of application is 2 mg/cm ² . Measure the moisture content after 30 minutes and 1 hour respectively. Repeat the same measurement three times and take the average to obtain the moisture content data. Continue to use it for sixteen Weeks, skin tests were conducted in the eighth and sixteenth weeks respectively. The results are shown in Table 3-Table 4.

Table 1 Average number of hair loss (roots)

As shown in Table 1, after the volunteers used the hair care solutions of Examples 1, 2, and 3 for sixteen weeks, the amount of hair loss was significantly reduced compared with before use (initial), and compared with Comparative Example 1 after using the hair care solutions for sixteen weeks The number of hair loss decreased significantly after 1 week. At the same time, the number of hair loss in Example 4 was also significantly improved compared with Comparative Example 1, indicating that the probiotic postbiotic composition of the present invention has a certain anti-hair loss effect.

Comparing Example 1 with Examples 5-6 and Comparative Example 1, it can be seen that the present invention uses calendula extract, resurrection grass extract and postbiotic ingredients to achieve the effect of synergistically promoting hair loss prevention.

Table 2 Hair Density (%)

As shown in Table 2, after sixteen weeks of using the hair care solutions of Examples 1, 2, and 3, the hair density of the volunteers became significantly larger than before use (initial), and compared with Comparative Example 1 after ten weeks of use. After six weeks, the hair density increased significantly. At the same time, Example 4 was also significantly improved compared with Comparative Example 2, indicating that the probiotic postbiotic composition of the present invention has a certain hair growth effect.

Comparing Example 1 with Examples 5-6 and Comparative Example 1, it can be seen that the present invention uses calendula extract, resurrection grass extract and postbiotic ingredients to achieve a synergistic effect in promoting hair growth.

Table 3 Skin moisture content

Table 4 Skin water loss rate (%)

It can be seen from the above results that the hydrating and moisturizing probiotic postbiotic composition prepared in the above embodiments and comparative examples of the present invention has a good hydrating and moisturizing effect, and all volunteers have no allergic or other discomfort reactions.

It can be seen from Examples 1, 2, 3 and 4 that after using the composition for sixteen weeks, the moisture content of the scalp cuticle increased as the amount of postbiotics added increased, and the water loss rate decreased accordingly. It can be seen from the results of Example 1 and Comparative Example 1 that the change rate of skin moisture content of 16w in Example 1 is 31.74%, and the change rate of water loss rate is -26.14%. Comparative Example 1 is 30.31% and -25.01 respectively. %; the change rate of 16w skin moisture content in Example 4 was 32.92%, the change rate of water loss rate was -27.40%, and Comparative Example 2 was 28.35% and -25.39% respectively, indicating that the addition of postbiotics better improved The hydrating and moisturizing effect of the composition is more conducive to improving the moisturizing performance of the scalp. The reason may be that the selected postbiotic ingredients have good ion resistance and are suitable for a wide pH range. By adding a small amount of low-cost ingredients in combination, a better effect can be achieved. Hydrating and moisturizing effect.

Obviously, the above-mentioned embodiments are only examples for clear explanation and are not intended to limit the implementation. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. An exhaustive list of all implementations is neither necessary nor possible. The obvious changes or modifications derived therefrom are still within the protection scope of the present invention.

Claims (10)

1. A probiotic postbiotic composition that improves the scalp environment, characterized in that it includes postbiotics obtained by fermentation of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602; The Lactobacillus paracasei ProSci-101 has a deposit number of CGMCC No. 26528; The Lactobacillus fermentum ProSci-602 has a deposit number of CGMCC NO.25451. 2. The probiotic postbiotic composition according to claim 1, further comprising 11-16% moisturizer, 3-9% oil, 3-7% skin conditioner, 0.8-1.6% Emulsifier, the postbiotic is 1.5-4.0%, and the balance is deionized water. 3. The probiotic postbiotic composition according to claim 2, wherein the moisturizing agent is glycerin, butylene glycol, allantoin, betaine, hydrolyzed sodium hyaluronate, gluconolactone, At least one of 1,3-propanediol and panthenol; And/or, the oil is at least one of squalane, jojoba oil, shea butter, borage oil, almond oil and linseed oil; And/or, the skin conditioning agent is at least one of p-hydroxyacetophenone, retinol, calendula extract, resurrection grass extract, pomegranate extract, and Atractylodes blooms extract; And/or, the emulsifier is oleth-10, PEG-100 stearate, PEG-10 polydimethylsiloxane, glyceryl oleate, polyglyceryl-6 polyricinoleate , at least one of cetearyl glucoside, sodium stearoyl lactylate, and sodium stearoyl glutamate. 4. The probiotic postbiotic composition according to claim 2 or 3, wherein the oil and fat constitute the oil phase A, and the postbiotic and other components other than the oil and fat constitute the water phase B. 5. The probiotic postbiotic composition according to claim 4, wherein the oil phase A includes squalane, jojoba oil and linseed oil; The aqueous phase B includes glycerol, butylene glycol, betaine, retinol, hydrolyzed sodium hyaluronate, calendula extract, resurrection grass extract, emulsifier and deionized water. 6. The probiotic postbiotic composition according to any one of claims 1 to 3, characterized in that the postbiotic includes antibacterial substances, active substances and short-chain fatty acids. 7. The probiotic postbiotic composition according to claim 6, wherein in the postbiotic, the antibacterial substance is an organic acid component; preferably, the organic acid component includes lactic acid 10-45 mg/g. , citric acid 100-200mg/g, oxalic acid 1.0-2.3mg/g, malic acid 0.5-3.0mg/g, phenyllactic acid 0.75-3.25mg/g, succinic acid 0.3-3.5mg/g, 4-hydroxyphenyllactic acid 0.2 -3.8mg/g, phenylalanine 0.03-2.9mg/g; more preferably, the organic acids also include salicylic acid 0.01-1.0mg/g, vanillic acid 0.01-0.8mg/g, benzoic acid 3-17mg/g, tartaric acid 0.01-1.2mg/g; And/or, in the postbiotics, the active substances include lauryl diethanolamine 1-5 mg/g, soy saponin 0.2-0.9 mg/g, soy isoflavones 0.05-2.25 mg/g, and γ-aminobutyric acid 0.1 -3.6mg/g, malonylgenistein 0.05-1.75mg/g, D-psicose 0.03-1.75mg/g, 3-indoleacrylic acid 0.01-0.5mg/g, genistein 0.01-0.5 mg/g, malonyl daidzein-0.03-0.5mg/g, irisone 0.5-3.5mg/g, Preaustinoid A 0.2-1.6mg/g, hyaluronic acid 0.02-1.85mg/g, extracellular polysaccharide 0.1- 5.0 mg/g, polypeptide 0.2-5.0 mg/g; preferably, the active substances also include isostearic acid 0.08-2.0 mg/g, trihydroxyflavone 0.02-2.5 mg/g, and daidzein 0.01-2.4 mg /g, butyrin 0.05-3.6mg/g; And/or, in the postbiotic, the short-chain fatty acids include acetic acid 10-80 mg/g, propionic acid 3-25 mg/g, butyric acid 0.05-10 mg/g, valeric acid 0.01-5 mg/g, and caproic acid 0.5 -12.0mg/g. 8. The method for preparing a probiotic postbiotic composition for improving the scalp environment according to any one of claims 1 to 7, characterized in that it includes: uniformly mixing other ingredients in the probiotic postbiotic composition except for postbiotics. After the mixture is obtained and sterilized, the postbiotics are added to the mixture when the temperature is lowered to 42-50°C and mixed well. 9. The preparation method according to claim 8, characterized in that the preparation process of the mixture is: Heat the oil to 80-85°C and stir evenly until it is completely dissolved and transparent to obtain oil phase A; Mix oil and other raw materials other than postbiotics, heat to 75-85°C and stir evenly until completely dissolved to obtain water phase B; Mix the oil phase A and the water phase B, and continue stirring until the mixture is uniform, and control the temperature at 75-80°C; Mix evenly to obtain a mixture; The mixture was then sterilized at 75-80°C for 30 minutes. 10. Application of the probiotic postbiotic composition for improving the scalp environment according to any one of claims 1 to 7 in products for improving the scalp environment and preventing hair loss; Preferably, the product is a liquid shampoo, conditioner, cream hair mask or hair care essential oil type care product; the content of postbiotics in the product is 1.5-4.0%.