CN113081942A - Multi-dimensional hydration cream containing apple stem cells - Google Patents

Abstract

The invention discloses a multi-vitamin water cream containing apple stem cells, which comprises the following components in parts by weight: EMULIUM DELTA 0.5-3.5%, polydimethylsiloxane 1-5%, cyclopentadimethylsiloxane 1-5%, polydimethylsiloxane cross-linked polymer 1-5%, and cyclohexasiloxane 1-5%; water phase: acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 6-11% of glycerol and pure water to 100%; active ingredients: 0.1-1% of mung bean fermentation liquor, 0.2-1.3% of glycerol glucoside, 0.1-0.5% of tabasheer bark extract, 0.1-0.5% of bisabolol, 1-2% of EPI epidermal repair factor, 0.1-0.5% of Artocarpus heterophyllus leaf/stem extract and 1-2% of apple fruit cell culture extract; 0.2 to 1 percent of preservative; pH regulators: 0.01 to 0.05 percent of sodium hydroxide. Compared with the prior art, the invention has the advantages that: the semi-permeable ointment has the characteristics that the oil-in-water property makes a water-in-oil skin feel, the skin is moist but not greasy, a layer of film is formed on the epidermis, the water is strongly locked, the skin is repaired by multi-dimensional water supplement, the skin is fully remodeled, is transparent and fine, and the young state of the skin is kept.

Description

Multi-dimensional hydration cream containing apple stem cells

Technical Field

The invention relates to the technical field of cosmetics, in particular to a multi-vitamin hydration cream containing apple stem cells.

Background

The skin care products containing lipids on the market are roughly divided into two categories: one is an "oil-in-water" formulation; one is a "water-in-oil" formulation. "water-in-oil" type: the proportion of oil is larger than that of water, and the oil content is more; the cream has thick, heavy and greasy texture, is mostly opaque white or yellow cream, is suitable for dry skin in autumn and winter, and is beneficial to locking water, keeping moisture and resisting external invasion. Oil-in-water type: the water has a larger proportion than oil, has refreshing texture, is in a semitransparent flowing liquid state, is quickly absorbed by skin, mainly plays a role in water supplement, and is suitable for mixed skin, oily skin or summer.

When the consumers select the water-in-oil type skin refreshing feeling, the consumers can worry about insufficient water replenishing and incapability of locking skin moisture, and the consumers select the water-in-oil type water locking feeling, do not want thick and greasy skin feeling and are not easy to absorb by the skin.

Dry skin has fine pores, is easy to dry and is easy to generate dry lines and wrinkles. The skin care product should be water-in-oil cold cream, and water can be absorbed into skin after being applied, so that the skin care product is moist and refreshing. The oily component can form an oily film on the skin surface, and has good moisturizing, softening and moistening effects on the skin. The neutral skin is smooth and fine, and an oil-in-water cream-shaped skin care product is selected to form an isolating film on the surface of the skin, so that the skin is isolated from the outside air, the excessive diffusion of the moisture of the epidermis is controlled, the stratum corneum is adjusted and protected, and the stratum contains a proper amount of moisture, thereby playing an important role in the softness, elasticity and health of the skin. The oily skin has a rough surface and obvious pores, is easy to produce closed mouth and acne, and has good moistening and humidifying effects on the skin by selecting fresh and moist skin care products or oil-in-water type emulsion.

Disclosure of Invention

The invention aims to provide the multi-dimensional hydrating cream containing the apple stem cells, which has the semi-permeable paste character, is moist but not greasy, forms a film on the epidermis, strongly locks water, and is multi-dimensionally moisturized to repair the skin, so that the skin is remolded, plump, transparent and fine, and the young state of the skin is kept.

The purpose of the invention is realized by the following technical scheme:

a multi-dimensional hydrating cream containing apple stem cells comprises the following components in parts by weight: EMULIUM DELTA 0.5-3.5%, polydimethylsiloxane 1-5%, cyclopentadimethylsiloxane 1-5%, polydimethylsiloxane cross-linked polymer 1-5%, and cyclohexasiloxane 1-5%; water phase: acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.1-0.25%, glycerol 6-11%, and pure water to 100%; active ingredients: 0.1-1% of mung bean fermentation liquor, 0.2-1.3% of glycerol glucoside, 0.5-2% of cloaca maculata bark extract, 0.1-0.5% of bisabolol, 1-2% of EPI epidermal repair factor, 0.1-0.5% of Ardisia crenata leaf/stem extract and 1-2% of apple fruit cell culture extract; 0.2 to 1 percent of preservative; pH regulators: 0.01 to 0.05 percent of sodium hydroxide.

Further, the EMULIUM DELTA component comprises: cetyl alcohol, glyceryl stearate, PEG-75 stearate, ceteth-20, steareth-20.

Further, the mung bean fermentation liquor comprises the following components: lactobacillus/semen phaseoli radiati (Phaseolus RADIATUS) seed extract/sodium glutamate fermentation filtrate, water, butylene glycol, glycerol, fructus Citri Grandis (Citrus GRANDIS) seed extract, rhizoma Acori Graminei (Acorus CALAMUS) root extract, and folium Perillae (Perilla octaOIDES) extract.

Further, the preservative is a mixture of two or more of glyceryl caprylate, caprylyl hydroxamic acid, 1, 2-pentanediol and 1.2-hexanediol.

Further, the pH value is in the range of 5.5 to 6.5.

A method for preparing multi-dimensional hydration cream containing apple stem cells comprises the following steps:

1) cleaning and disinfecting emulsification equipment;

2) accurately weighing oil phase raw materials, adding into an oil phase pot, heating and stirring to 80 deg.C for dissolving completely;

3) accurately weighing water phase raw materials, adding into an emulsifying pot, stirring, heating to 80-85 deg.C, dissolving completely, homogenizing for 3-5 min, and stirring for 30 min under heat preservation;

4) pumping the dissolved oil phase into the water phase through a filtering device, homogenizing at the rotation speed of 500-1000r/min for 3-5 minutes, and vacuumizing for defoaming;

5) cooling to 60 ℃, dissolving the sodium hydroxide and the 5% water uniformly, adding the mixture into a pot, stirring uniformly, and keeping the temperature and stirring for 30 minutes;

6) cooling to 45 deg.C, sequentially adding active ingredient and antiseptic, stirring, adding sodium hydroxide to adjust pH, and discharging.

Compared with the prior art, the invention has the advantages that:

the mung bean fermentation liquor uses a natural mung bean fermentation product fermented by lactobacillus, has a soothing effect on sensitive skin, promotes the synthesis of collagen, promotes the proliferation of fiber cells, is fermented by probiotics, is safe and effective, and enhances the skin barrier function; effectively clean skin, keep moisture, resist acne, enhance skin elasticity, relax and relax mind, and maintain beautiful skin.

The glycerol glucoside is used for extracting the dead grass during the flowering and is pure, and the activity and the metabolism of skin cells are enhanced; restoring aged cells to a young cell state; promoting the generation of collagen, slowing down the aging process of skin cells, activating and regenerating skin cells, accelerating wound healing and tissue repair, relieving skin redness and resisting erythra; the moisturizing factor can increase the moisturizing property, elasticity and smoothness of the skin, make the skin smooth and tender, and recover and keep the light state.

The tabebuia avellanedae bark extract has anti-inflammatory effect to improve skin resistance, inhibit degranulation, inhibit PGE2 synthesis, and eliminate free radical, and can be used for treating skin problems such as erythema, pruritus, erythra or pain caused by dust, microorganism and irritants by acting on chemical medium to release inflammatory chemical medium, so as to keep skin in a healthy state.

The EPI epidermal repair factor component comprises: butanediol, glycerol, serine, glycine, alanine, arginine, aspartic acid, valine, isoleucine, leucine, glutamic acid, proline, sodium lactate, potassium hydroxide, citric acid and water. The skin-care product is rich in various amino acids, is a component of natural moisturizing factors, prevents the moisture loss of the skin, can be used for moisturizing various skins, effectively improves the skin problems of dry skin, roughness, large pores and the like, and the repair of the epidermal layer is the first step of perfect skin, emphasizes on the use feeling, has no sticky feeling, has smooth and soft skin feeling and fresh and moist feeling, and is fresh, moist and not tight.

The millettia speciosa leaf/stem extract is obtained by crushing dead grass in Germany, injects oasis-like vitality into desert-like skin, reduces oxidative stress, protects skin lipid, prolongs skin moisturizing time to 48 hours, reduces intracellular water diversion and stabilizes cell membranes, prevents cell wall damage, can also utilize self capacity to assist the repair process of cells after the cells are damaged, meets the challenge of harsh environment (dry or long-term exposure), provides protection for skin cells, stabilizes skin, sustains moisture, improves skin texture and redness, is visible to the naked eye, activates dry areas, strengthens skin barriers, has pleasant skin feeling after use, and enables the skin to be regenerated.

The apple fruit cell culture extract is obtained by crushing precious apples of Switzerland, can effectively protect epidermis and hair follicle stem cells, activate dormant stem cells, improve the gene expression of 'aged' cells, reduce the primary activity of the epidermis stem cells, continuously replace the aged cells, is rich in specific epigenetic factors and metabolites of the Switzerland apples, has the effects of maintaining the cell life and protecting the activity of the stem cells, has more durable proliferative capacity of the skin stem cells, and simultaneously prolongs the capacity of the skin stem cells in carrying out complex layering and differentiation processes, so the apple stem cells can help the epidermis stem cells to self-renew, differentiate cells, repair damaged cells and tissues, resist oxygen and tighten the skin, remold, enable the skin to be transparent and fine and keep the young state of the skin.

The invention provides a multi-dimensional hydration cream containing apple stem cells, which is in a semi-permeable paste shape, has a water-in-oil skin feeling due to an oil-in-water property, is moist but not greasy, forms a film on the epidermis, strongly locks water, and is capable of multi-dimensionally moisturizing and repairing the skin, so that the skin is fully remodeled, transparent and fine, and the young state of the skin is kept. The skin moisturizing cream has the advantages of supplementing moisture to the skin, improving the resistance of the skin, promoting the generation of skin collagen, enhancing the cell activity, and achieving the moisturizing and long-lasting health state of the skin by matching exogenous water with endogenous water.

Drawings

Fig. 1 is a moisturizing efficacy test.

Detailed Description

Example 1

A multi-dimensional hydration cream containing apple stem cells comprises the following components in percentage by mass: oil phase: EMULIUM DELTA 2%, polydimethylsiloxane 2%, cyclopentadimethicone 3%, dimethicone crosspolymer 3%, cyclohexasiloxane 2%;

water phase: acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.2%, glycerol 8%, pure water to 100%;

active ingredients: 0.8% of mung bean fermentation liquor, 0.5% of glycerol glucoside, 1% of clockwork bark extract, 0.35% of bisabolol, 1.5% of EPI epidermal repair factor, 0.4% of Artocarpus heterophyllus leaf/stem extract and 2% of apple fruit cell culture extract;

0.8% of preservative; pH regulators: 0.02 percent of sodium hydroxide.

Example 2:

a multi-dimensional hydration cream containing apple stem cells comprises the following components in percentage by mass: oil phase: EMULIUM DELTA 3.5%, polydimethylsiloxane 5%, cyclopentadimethylsiloxane 1%, dimethicone crosspolymer 1%, cyclohexasiloxane 5%;

water phase: acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.1%, glycerol 6-11%, pure water to 100%;

active ingredients: 0.1% of mung bean fermentation liquor, 0.2% of glycerol glucoside, 2% of clockwork bark extract, 0.5% of bisabolol, 2% of EPI epidermal repair factor, 0.5% of Artocarpus heterophyllus leaf/stem extract and 1% of apple fruit cell culture extract;

0.2 to 1 percent of preservative; pH regulators: 0.05 percent of sodium hydroxide.

Example 3

A multi-dimensional hydration cream containing apple stem cells comprises the following components in percentage by mass: oil phase: EMULIUM DELTA 0.5%, polydimethylsiloxane 1%, cyclopentadimethylsiloxane 1%, polydimethylsiloxane crosspolymer 1%, cyclohexasiloxane 1%;

water phase: acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.15%, glycerol 6%, pure water to 100%;

active ingredients: 0.1% of mung bean fermentation liquor, 1.3% of glycerol glucoside, 0.5% of clockwork bark extract, 0.1% of bisabolol, 1% of EPI epidermal repair factor, 0.1% of Artocarpus heterophyllus leaf/stem extract and 1% of apple fruit cell culture extract;

0.2 percent of preservative; pH regulators: 0.01 percent of sodium hydroxide.

Example 4

A method for preparing multidimensional hydration cream containing apple stem cells comprises the following steps: 1) cleaning and disinfecting emulsification equipment; 2) accurately weighing oil phase raw materials, adding into an oil phase pot, heating and stirring to 80 deg.C for dissolving completely; 3) accurately weighing water phase raw materials, adding the water phase raw materials into an emulsifying pot, stirring and heating to 82 ℃, dissolving completely, homogenizing for 4 minutes properly, and stirring for 30 minutes under heat preservation; 4) pumping the dissolved oil phase into the water phase through a filtering device, homogenizing at a low speed for 4 minutes, and vacuumizing for defoaming; 5) cooling to 60 ℃, dissolving the sodium hydroxide and the 5% water uniformly, adding the mixture into a pot, stirring uniformly, and keeping the temperature and stirring for 30 minutes; 6) cooling to 45 deg.C, sequentially adding active ingredient and antiseptic, stirring, adding sodium hydroxide to adjust pH, and discharging.

Examples 1-3 the preparation provided in example 4 was used.

Comparative example 1

The difference from example 1 is that no active ingredient EPI epidermal repair factor is added.

Comparative example 2

The difference from example 1 is that apple stem cells were not added.

Comparative example 3

The difference from example 1 is that no mung bean fermentation broth, glycerol glucoside, was added.

And (3) moisturizing efficacy verification: the stratum corneum moisture content was measured as shown in FIG. 1.

30 volunteers, 20-50 years old, dry skin were selected, cleaned in the morning and evening and applied to the cheek for 3 weeks.

Using an instrument: CORNEOMETER CM825

And (4) conclusion: as can be seen from the data in FIG. 1, it can be seen that the skin stratum corneum of the subjects had significantly increased moisture after the use of the hydration creams provided in examples 1-3.

Transcutaneous water loss TEWL measurement:

30 volunteers, 20-50 years old, female and neutral skin are selected, and the facial skin is smeared after cleaning the face in the morning and evening every day, is used for 3 weeks and is detected at the cheek.

Using an instrument: tewameter TM300

Table 1: comparison of TEWL values at various times (average, n 80, g/m2h)

	Before smearing	After being smeared for 1 hour	After 1 week of use	After 3 weeks of use
					Example 1	13.2	11.9	10.1	9.9
Example 2	13.5	12.5	10.7	10.2
					Example 3	13.3	12.4	10.6	10.3
Comparative example 1	13.2	12.9	12.9	12.2
					Comparative example 2	12.9	12.7	12.7	12.1
Comparative example 3	13.1	12.9	12.8	12.3

And (4) conclusion: as can be seen from the data in Table 1, the TEWL value of the multi-vitamin hydrating cream prepared in examples 1-3 is obviously reduced, the skin moisture loss can be reduced, the water is strongly locked, and the skin is moisturized.

Claims (6)

1. A multi-dimensional hydrating cream containing apple stem cells is characterized by comprising the following components in parts by weight: EMULIUMDELTA 0.5-3.5%, polydimethylsiloxane 1-5%, cyclopentadimethylsiloxane 1-5%, polydimethylsiloxane cross-linked polymer 1-5%, and cyclohexasiloxane 1-5%; water phase: acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer 0.1-0.25%, glycerol 6-11%, and pure water to 100%; active ingredients: 0.1-1% of mung bean fermentation liquor, 0.2-1.3% of glycerol glucoside, 0.5-2% of cloaca maculata bark extract, 0.1-0.5% of bisabolol, 1-2% of EPI epidermal repair factor, 0.1-0.5% of Ardisia crenata leaf/stem extract and 1-2% of apple fruit cell culture extract; 0.2 to 1 percent of preservative; pH regulators: 0.01 to 0.05 percent of sodium hydroxide.

2. The multi-dimensional hydration cream containing apple stem cells according to claim 1, wherein the EMULIUM DELTA component comprises: cetyl alcohol, glyceryl stearate, PEG-75 stearate, ceteth-20, steareth-20.

3. The multi-vitamin water cream containing apple stem cells as claimed in claim 1, wherein the mung bean fermentation broth ingredients comprise: lactobacillus/semen phaseoli radiati (Phaseolus RADIATUS) seed extract/sodium glutamate fermentation filtrate, water, butylene glycol, glycerol, fructus Citri Grandis (Citrus GRANDIS) seed extract, rhizoma Acori Graminei (Acorus CALAMUS) root extract, and folium Perillae (Perilla octaOIDES) extract.

4. The multi-dimensional hydration cream containing apple stem cells according to claim 1, wherein the preservative is a mixture of two or more of caprylic acid, caprylyl hydroximic acid, 1, 2-pentanediol, and 1.2-hexanediol.

5. The multi-vitamin hydration cream containing apple stem cells according to claim 1, wherein the PH is in the range of 5.5-6.5.

6. A preparation method of multi-dimensional hydration cream containing apple stem cells is characterized by comprising the following steps:

1) cleaning and disinfecting emulsification equipment;

2) accurately weighing oil phase raw materials, adding into an oil phase pot, heating and stirring to 80 deg.C for dissolving completely;

3) accurately weighing water phase raw materials, adding into an emulsifying pot, stirring, heating to 80-85 deg.C, dissolving completely, homogenizing for 3-5 min, and stirring for 30 min under heat preservation;

4) pumping the dissolved oil phase into the water phase through a filtering device, homogenizing at the rotation speed of 500-1000r/min for 3-5 minutes, and vacuumizing for defoaming;

5) cooling to 60 ℃, dissolving the sodium hydroxide and the 5% water uniformly, adding the mixture into a pot, stirring uniformly, and keeping the temperature and stirring for 30 minutes;

6) cooling to 45 deg.C, sequentially adding active ingredient and antiseptic, stirring, adding sodium hydroxide to adjust pH, and discharging.

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