CN117281762A - High-performance skin care composition and preparation method and application thereof - Google Patents
High-performance skin care composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN117281762A CN117281762A CN202311589160.XA CN202311589160A CN117281762A CN 117281762 A CN117281762 A CN 117281762A CN 202311589160 A CN202311589160 A CN 202311589160A CN 117281762 A CN117281762 A CN 117281762A
- Authority
- CN
- China
- Prior art keywords
- glossy privet
- extract
- skin care
- parts
- privet fruit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 239000000284 extract Substances 0.000 claims description 104
- 241000830535 Ligustrum lucidum Species 0.000 claims description 71
- 235000013399 edible fruits Nutrition 0.000 claims description 70
- 238000000855 fermentation Methods 0.000 claims description 60
- 230000004151 fermentation Effects 0.000 claims description 60
- 241000221095 Simmondsia Species 0.000 claims description 52
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 52
- 238000002156 mixing Methods 0.000 claims description 36
- 239000000706 filtrate Substances 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000002608 ionic liquid Substances 0.000 claims description 23
- 239000004094 surface-active agent Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
- 239000007791 liquid phase Substances 0.000 claims description 15
- 241000186660 Lactobacillus Species 0.000 claims description 14
- 229940069521 aloe extract Drugs 0.000 claims description 14
- 230000001815 facial effect Effects 0.000 claims description 14
- 229940039696 lactobacillus Drugs 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 12
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 238000005191 phase separation Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000007790 solid phase Substances 0.000 claims description 7
- 238000009210 therapy by ultrasound Methods 0.000 claims description 7
- 239000004471 Glycine Substances 0.000 claims description 6
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 6
- 235000004279 alanine Nutrition 0.000 claims description 6
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 229920002261 Corn starch Polymers 0.000 claims description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 5
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 5
- 239000008120 corn starch Substances 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 4
- 239000001569 carbon dioxide Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 108700004121 sarkosyl Proteins 0.000 claims description 4
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 4
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 4
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 3
- 244000060011 Cocos nucifera Species 0.000 claims description 3
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 229940049964 oleate Drugs 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- 229940104261 taurate Drugs 0.000 claims description 3
- 229940071160 cocoate Drugs 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 238000004042 decolorization Methods 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 2
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 239000000047 product Substances 0.000 description 65
- 230000000694 effects Effects 0.000 description 30
- 235000019198 oils Nutrition 0.000 description 30
- 230000000052 comparative effect Effects 0.000 description 22
- 238000012360 testing method Methods 0.000 description 15
- 230000003020 moisturizing effect Effects 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 8
- 239000013543 active substance Substances 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 230000007774 longterm Effects 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- 229930091371 Fructose Natural products 0.000 description 5
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 5
- 239000005715 Fructose Substances 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000010298 pulverizing process Methods 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000004202 carbamide Substances 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000002390 rotary evaporation Methods 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 235000014104 aloe vera supplement Nutrition 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 2
- 241000283977 Oryctolagus Species 0.000 description 2
- 241001122767 Theaceae Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 210000000795 conjunctiva Anatomy 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 229940068517 fruit extracts Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000000554 iris Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 231100000286 mucous membrane, eye irritation or corrosion testing Toxicity 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229940060304 sodium myristoyl sarcosinate Drugs 0.000 description 1
- IPUUFZFIUKCPJN-UHFFFAOYSA-M sodium;2-(hexadecanoylamino)acetate Chemical group [Na+].CCCCCCCCCCCCCCCC(=O)NCC([O-])=O IPUUFZFIUKCPJN-UHFFFAOYSA-M 0.000 description 1
- KHCOJQDJOCNUGV-UHFFFAOYSA-M sodium;2-[methyl(tetradecanoyl)amino]acetate Chemical group [Na+].CCCCCCCCCCCCCC(=O)N(C)CC([O-])=O KHCOJQDJOCNUGV-UHFFFAOYSA-M 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a high-performance skin care composition, a preparation method and application thereof, and belongs to the field of cosmetics.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a high-performance skin care composition and a preparation method and application thereof.
Background
In the prior art, a skin care cleaning product is generally required to have various performances including oil control, acne removal and the like besides basic cleaning and moisturizing performances, so that the components of the skin care cleaning product are more complex, and the problem is that the functional components in the skin care cleaning product are gradually increased, the skin care cleaning product is more prone to the property of medicines, and skin irritation can be caused to sensitive muscles or infant users.
On the other hand, some skin care cleansing products contain natural non-irritating oil-controlling and moisturizing plant source components, but the permeation efficiency of the components is low, the effect on the skin is very small under the condition of small addition and short-time use, if the proportion of the components is increased, the stability of the prepared skin care cleansing products is possibly reduced, adverse phenomena such as 'particle clusters', 'layering' and the like are easy to occur after the skin care cleansing products are stored for a period of time, the natural components are easy to be influenced by environment, the activity efficacy is rapidly attenuated with the passage of time, and the shelf life is short.
Disclosure of Invention
Based on the defects existing in the prior art, the invention aims to provide the high-performance skin care composition, the glossy privet fruit extract prepared by supercritical carbon dioxide extraction is used as a raw material, then the natural plant fermentation filtrate is prepared by lactobacillus fermentation, and finally the aloe extract, the specific type of amino acid surfactant and the thickening agent are compounded, so that the rapid permeation and absorption can be realized during use, the absorption process is mild and has no stimulation, good oil control and moisturizing effects are realized, meanwhile, the stability of the natural functional components is strong, the adverse phenomenon of the product is avoided, and the shelf life is long.
A high-performance skin care composition comprises the following components in parts by weight:
1-1.5 parts of glossy privet fruit extract fermentation filtrate, 0.1-0.3 part of aloe extract, 1-3 parts of acrylamide dimethyl taurate/VP copolymer and 8-10 parts of N-amido surfactant;
the glossy privet fruit extract fermentation filtrate is obtained by fermenting glossy privet fruit extract by lactobacillus;
the fructus Ligustri Lucidi extract is obtained by supercritical carbon dioxide extraction of fructus Ligustri Lucidi.
The glossy privet fruit contains very abundant active ingredients including various kinds of polysaccharide, alkaloid, saturated and unsaturated fatty acid, vitamin and the like, wherein the prior art has been researched to show that the glossy privet fruit has a certain inhibition effect on 5 alpha-reductase in human skin, and the 5 alpha-reductase has a great relation with the secretion of sebaceous glands of the human body, so that the active ingredients in the fruit have a beneficial effect on controlling the secretion of grease of the human skin, and in addition, the natural plant also has a certain effect of improving the moisture content of the skin, so that the glossy privet fruit is an ideal skin care product ingredient in theory. However, experiments of the inventor find that the glossy privet fruit extract prepared by the traditional process has complex components, and when the glossy privet fruit extract is compounded to prepare skin care products, particularly products containing various surfactants and other active ingredients, the glossy privet fruit extract not only can cause unexpected performance due to component oxidation failure, but also can cause the conditions of color change and particle cluster generation after long-term storage of the products.
Therefore, the inventor firstly adopts supercritical extraction to extract the glossy privet fruit, the method can effectively extract active ingredients (including thermosensitive and easily-deformable components) in the glossy privet fruit, and then the obtained extract is fermented by lactobacillus, as lactobacillus can convert easily-oxidized substances such as fructose, starch, protein and the like in the extract into functional ingredients with active functions on skin, the prepared glossy privet fruit extract fermentation filtrate has better oil control and moisturizing effects and stronger stability compared with the extract obtained by independently extracting or extracting the glossy privet fruit, and under the basis, the inventor adopts a specific amino acid surfactant N-amido surfactant and an organic surfactant ammonium acryloyldimethyl taurate/VP copolymer to compound, so that the component has stronger permeability after contacting skin, and the instant oil control effect is realized. If two of the surfactant systems are replaced, not only the activity effect of the fermentation filtrate of the glossy privet fruit extract is poor, but also the shelf life of the product is possibly shortened.
However, the glossy privet fruit extract fermentation filtrate alone cannot achieve the effect of rapid moisture retention, so the inventor takes aloe extract as a collocation type active efficacy component, and as a result, the inventor finds that after a small amount of aloe extract is introduced, the aloe extract and the glossy privet fruit extract fermentation filtrate can achieve obvious synergistic effect on the moisture retention effect, so that the product can achieve the high moisture retention in a short time.
Preferably, the N-amido surfactant is at least one of sodium lauroyl sarcosinate and sodium lauroyl glutamate.
The N-amido surfactant is a surfactant with high safety and good biocompatibility, and the substance contains rich hydrophilic groups, so that the N-amido surfactant can effectively serve as a transportation bridge between fermentation filtrate of glossy privet fruit extracts and aloe extracts and skin, and active substances from two plants can fully permeate into the skin to play roles in controlling oil and preserving moisture; on the other hand, after the organic surfactant thickener of the ammonium acryloyldimethyl taurate/VP copolymer is matched, each component of the skin care composition has long-term stability even under the condition that a plurality of emulsifying agents are not introduced in the preparation process, so that the product can not have the problems of efficacy failure, shape change and the like after long-term storage; finally, the N-amido surfactant also has a certain antibacterial effect, and can further prolong the shelf life of the product.
Preferably, the preparation method of the glossy privet fruit extract comprises the following steps: crushing the cleaned and dried glossy privet fruits, placing the crushed glossy privet fruits into an extraction kettle containing 1L of supercritical carbon dioxide, and extracting for 2-4 hours at 25-35 ℃ and 20-40 MPa to obtain glossy privet fruit extracts;
more preferably, the flow rate of the supercritical carbon dioxide is 20-30L/h.
Preferably, the preparation method of the glossy privet fruit extract fermentation filtrate comprises the following steps: adding the glossy privet fruit extract into a fermentation medium, then inoculating lactobacillus, fermenting for 80-120 hours at 25-35 ℃, sterilizing, centrifuging, and removing solids to obtain the glossy privet fruit extract fermentation filtrate.
The glossy privet fruit extract has higher content of active substances compared with glossy privet fruit, so after lactobacillus is further inoculated for fermentation, unstable substances in the active substances or micromolecular substances with insignificant activity effect can be converted and consumed, and macromolecular active substances are converted into fermentation products with remarkable oil control and moisture preservation effects on skin, in the process, the inventor finds that the fermentation condition of lactobacillus can be carried out without special fermentation temperature only by adopting normal 25-35 ℃, the operation is convenient, the fermentation time has certain influence on the performance of the product, the fermentation time is too short, the conversion degree of the fermentation products is lower, the stability and the skin activity of the product are insufficient, but if the fermentation time is too long, partial active substances are converted excessively, the activity effect is reduced, and the effect is optimal by 80-120 h.
More preferably, the lactobacillus is inoculated in an amount of 1 to 2vol%.
More preferably, the fermentation medium comprises the following components in parts by weight based on 100 parts: 20-35 parts of glossy privet fruit extract, 5-10 parts of glucose, 1-5 parts of fructose, 5-10 parts of urea and the balance of water.
More preferably, the centrifugal speed is 3000-4000 r/min and the centrifugal time is 1-2 h when the solids are removed by centrifugation.
Preferably, the components of the high-performance skin care composition also contain 0.1-0.3 part of jojoba seed extract;
more preferably, the jojoba seed extract is obtained by extracting jojoba seeds with an ionic liquid.
More preferably, the preparation method of the jojoba seed extract comprises the following steps: crushing jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to the mass ratio of (1-3): (18-22) mixing, carrying out ultrasonic treatment for 20-30 min, carrying out solid phase separation, and carrying out decolorization treatment on the obtained liquid phase to obtain the jojoba seed extract.
More preferably, the ionic liquid is a mixture of glycine and alanine, and the mass ratio of the glycine to the alanine is (0.8-1.2): (0.8-1.2).
The jojoba seeds contain rich oil phase substances and are moisture-preserving components of traditional skin care products, but the product contains more unsaturated fatty acids with higher activity and is easy to be induced to deteriorate by external environment, so that after the skin care products are prepared, the moisture-preserving activity of the product can be attenuated along with the time, and even the long-acting moisture-preserving property of the product is influenced in the product, in order to overcome the defect of jojoba seed oil, the inventor extracts the jojoba seeds by ionic liquid of specific types, and compared with the jojoba seed oil prepared by traditional cold pressing and refining, the jojoba seed extract prepared by the invention has higher stability and component compatibility, can keep stability and bioactivity even under higher temperature and light, and can further improve the moisture-preserving property and activity long-acting property of the product.
Another object of the present invention is to provide a high performance skin care cleansing emulsion comprising the high performance skin care composition of the present invention.
Preferably, the high performance skin care cleansing emulsion further comprises a solvent;
more preferably, the solvent comprises water.
More preferably, the high-performance skin care facial cleanser comprises the following components in parts by weight based on 100 parts:
8-12 parts of glycerin, 1-1.5 parts of glossy privet fruit extract fermentation filtrate, 0.1-0.3 part of aloe extract, 1-3 parts of acrylamide/VP copolymer, 1-3 parts of disodium cocoate monoethanolamide sulfosuccinate, 1-3 parts of corn starch, 8-10 parts of N-amido surfactant, 0.1-0.3 part of jojoba seed extract, 100.1-0.2 part of polyglycerol, 0.5-1 part of sodium alginate, 0.1-0.5 part of p-hydroxyacetophenone, 0.1-0.5 part of hexanediol and the balance of water.
Under the combined action of the fermentation filtrate of the glossy privet fruit extract, the aloe extract and the jojoba seed extract, the high-performance skin care composition not only has synergistic oil control and moisturizing effects, but also has good activity timeliness and stability, after a specific type of surfactant and a thickener are compounded, the component stability of the product is strong, and obvious morphological change can not occur after long-term storage; the product has simple components, is safe and has no stimulation, is suitable for users with various skin conditions, and can effectively realize moisture preservation and oil control when the user uses the product for cleaning the face in a short time after compounding the high-performance skin care facial cleanser, and the effect is far better than that of the conventional product prepared by adopting other formulas after clinical experiments.
The invention also aims at providing a preparation method of the high-performance skin care facial cleanser, which comprises the following steps of:
adding proper water into the ammonium acryloyldimethyl taurate/VP copolymer, disodium cocoanut oleate monoethanolamide sulfosuccinate, corn starch, N-amido surfactant and polyglycerol-10, and uniformly mixing at 90-95 ℃ to obtain solution A;
adding proper water into glycerol, sodium alginate, p-hydroxyacetophenone and hexanediol, and uniformly mixing to obtain solution B;
and mixing and stirring the solution A and the solution B at 50-60 ℃ for 20-30 min, cooling, and then adding the glossy privet fruit extract fermentation filtrate, the aloe extract and the jojoba seed extract, and continuously and uniformly mixing to obtain the high-performance skin-care facial cleanser.
The invention has the beneficial effects that the invention provides the high-performance skin care composition, the glossy privet fruit extract prepared by supercritical carbon dioxide extraction is used as a raw material, then the natural plant fermentation filtrate is prepared by lactobacillus fermentation, and finally the aloe extract, the specific type of amino acid surfactant and the thickening agent are compounded, so that the high-performance skin care composition can realize rapid permeation and absorption during use, the absorption process is mild and has no stimulation, good oil control and moisturizing effects are realized, meanwhile, the stability of the natural functional components is strong, the adverse phenomenon of the product is avoided, and the shelf life is long.
Detailed Description
The present invention will be further described with reference to specific examples and comparative examples for better illustrating the objects, technical solutions and advantages of the present invention, and the object of the present invention is to be understood in detail, not to limit the present invention. All other embodiments, which can be made by those skilled in the art without the inventive effort, are intended to be within the scope of the present invention. The experimental reagents and instruments involved in the practice of the present invention are common reagents and instruments unless otherwise specified.
Examples 1 to 4
The high-performance skin care composition is used for preparing skin care facial cleanser, and the composition of the skin care facial cleanser is shown in table 1.
TABLE 1
The preparation method of the glossy privet fruit extract fermentation filtrate comprises the following steps:
(1) Pulverizing cleaned and dried fructus Ligustri Lucidi, placing into an extraction kettle containing 1L supercritical carbon dioxide with flow rate of 30L/h, extracting at 30deg.C under 30MPa for 2 hr, and removing excessive liquid phase to obtain fructus Ligustri Lucidi extract;
(2) Adding the glossy privet fruit extract into a fermentation medium, then inoculating 1vol% of lactobacillus, fermenting for 120 hours at 25-35 ℃, sterilizing, centrifuging the obtained mixture in a centrifuge at 3000r/min for 2 hours, and taking a liquid phase as a glossy privet fruit extract fermentation filtrate; wherein the fermentation medium contains 25 parts of glossy privet fruit extract, 10 parts of glucose, 5 parts of fructose, 5 parts of urea and 55 parts of water.
The aloe extract is a commercial aloe vera extract product;
the preparation method of the jojoba seed extract comprises the following steps: crushing fresh and dried jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to a mass ratio of 2:20, mixing and carrying out ultrasonic treatment for 30min, and carrying out solid phase separation, wherein the obtained liquid phase is decolorized by a commercially available alkaline fiber adsorption column to obtain the jojoba seed extract; the preparation method of the ionic liquid comprises the following steps: and (3) dissolving glycine and alanine in a mass ratio of 1:1 into water according to a solid-to-liquid ratio of 1g:10L, mixing and stirring for 48 hours, and performing rotary evaporation and drying to obtain the ionic liquid.
The preparation method of the skin care facial cleanser comprises the following steps:
adding proper water into the ammonium acryloyldimethyl taurate/VP copolymer, disodium cocoanut oleate monoethanolamide sulfosuccinate, corn starch, N-amido surfactant and polyglycerol-10, and uniformly mixing at 95 ℃ to obtain solution A;
adding proper water into glycerol, sodium alginate, p-hydroxyacetophenone and hexanediol, and uniformly mixing to obtain solution B;
mixing the solution A and the solution B at 60deg.C, stirring for 30min, cooling, adding fructus Ligustri Lucidi extract fermentation filtrate, aloe extract and jojoba seed extract (except in example 4), and mixing to obtain the high-performance skin care facial cleanser.
Example 5
The embodiment of the high-performance skin care composition, the preparation method and the application thereof, disclosed by the invention, are different from the embodiment 1 only in that the fermentation time of the fermentation filtrate of the glossy privet fruit extract is 80 hours.
Example 6
The embodiment of the high-performance skin care composition, the preparation method and the application thereof, disclosed by the invention, are different from the embodiment 1 only in that the fermentation time of the fermentation filtrate of the glossy privet fruit extract is 60 hours.
Example 7
The embodiment of the high-performance skin care composition, the preparation method and the application thereof, disclosed by the invention, are different from the embodiment 1 only in that the fermentation time of the fermentation filtrate of the glossy privet fruit extract is 140 hours.
Example 8
The embodiment of the invention, the preparation method and the application thereof are different from the embodiment 1 only in that the preparation method of the jojoba seed extract is as follows: crushing fresh and dried jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to a mass ratio of 2:20, mixing and carrying out ultrasonic treatment for 30min, and carrying out solid phase separation, wherein the obtained liquid phase is decolorized by a commercially available alkaline fiber adsorption column to obtain the jojoba seed extract; the preparation method of the ionic liquid comprises the following steps: and (3) dissolving arginine and alanine in a mass ratio of 1:1 into water according to a solid-to-liquid ratio of 1g:10L, mixing and stirring for 48 hours, and performing rotary evaporation and drying to obtain the ionic liquid.
Example 9
The embodiment of the invention, the preparation method and the application thereof are different from the embodiment 1 only in that the preparation method of the jojoba seed extract is as follows: the preparation method of the jojoba seed extract comprises the following steps: crushing fresh and dried jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to a mass ratio of 2:20, mixing and carrying out ultrasonic treatment for 30min, and carrying out solid phase separation, wherein the obtained liquid phase is decolorized by a commercially available alkaline fiber adsorption column to obtain the jojoba seed extract; the preparation method of the ionic liquid comprises the following steps: and (3) dissolving glycine and arginine in a mass ratio of 1:1 into water according to a solid-to-liquid ratio of 1g:10L, mixing and stirring for 48 hours, and performing rotary evaporation and drying to obtain the ionic liquid.
Example 10
The embodiment of the invention, the preparation method and the application thereof are different from the embodiment 1 only in that the preparation method of the jojoba seed extract is as follows: the preparation method of the jojoba seed extract comprises the following steps: crushing fresh and dried jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to a mass ratio of 2:20, mixing and carrying out ultrasonic treatment for 30min, and carrying out solid phase separation, wherein the obtained liquid phase is decolorized by a commercially available alkaline fiber adsorption column to obtain the jojoba seed extract; the preparation method of the ionic liquid comprises the following steps: and (3) dissolving glycine in water according to a solid-to-liquid ratio of 1g to 10L, mixing and stirring for 48 hours, and performing rotary evaporation and drying to obtain the ionic liquid.
Example 11
The embodiment of the invention, the preparation method and the application thereof are different from the embodiment 1 only in that the preparation method of the jojoba seed extract is as follows: the preparation method of the jojoba seed extract comprises the following steps: crushing fresh and dried jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to a mass ratio of 2:20, mixing and carrying out ultrasonic treatment for 30min, and carrying out solid phase separation, wherein the obtained liquid phase is decolorized by a commercially available alkaline fiber adsorption column to obtain the jojoba seed extract; the preparation method of the ionic liquid comprises the following steps: dissolving alanine in water according to a solid-to-liquid ratio of 1g to 10L, mixing and stirring for 48 hours, and spin-evaporating and drying to obtain the ionic liquid.
Example 12
The high performance skin care composition, the preparation method and the application example of the high performance skin care composition are different from the example 1 only in that the jojoba seed extract is replaced by commercially available jojoba seed oil.
Comparative example 1
An embodiment of a skin care composition, a preparation method and an application thereof are different from embodiment 1 only in that the glossy privet fruit extract fermentation filtrate is replaced by a glossy privet fruit extract, and the preparation method of the glossy privet fruit extract is as follows: pulverizing cleaned and dried fructus Ligustri Lucidi, extracting with ethanol at 30deg.C under 30MPa for 2 hr, leaching for 5 times, filtering to obtain solid, and volatilizing the liquid phase to obtain fructus Ligustri Lucidi extract.
Comparative example 2
An embodiment of a skin care composition, a preparation method and an application thereof are different from embodiment 1 only in that the glossy privet fruit extract fermentation filtrate is replaced by a glossy privet fruit extract, and the preparation method of the glossy privet fruit extract is as follows: pulverizing 5g of cleaned and dried fructus Ligustri Lucidi, adding 500mL of water, mixing at 60deg.C, stirring for 2 hr, filtering to obtain solid, and naturally drying the liquid phase to obtain fructus Ligustri Lucidi extract.
Comparative example 3
An embodiment of a skin care composition, a preparation method and an application thereof, which are different from embodiment 1 only in that the glossy privet fruit extract fermentation filtrate is replaced by a glossy privet fruit fermentation product, and the preparation method of the glossy privet fruit fermentation product is as follows:
pulverizing the cleaned and dried glossy privet fruits, adding the crushed glossy privet fruits into a fermentation medium, inoculating 1vol% of lactobacillus, fermenting for 120 hours at 25-35 ℃, sterilizing, centrifuging the obtained mixture in a centrifuge at 3000r/min for 2 hours, and taking a liquid phase as a glossy privet fruit extract fermentation filtrate; wherein the fermentation medium contains 25 parts of glossy privet fruits, 10 parts of glucose, 5 parts of fructose, 5 parts of urea and 55 parts of water.
Comparative example 4
An embodiment of a skin care composition, a preparation method and an application thereof are different from embodiment 1 only in that the preparation method of the glossy privet fruit extract fermentation filtrate is as follows:
(1) Pulverizing cleaned and dried fructus Ligustri Lucidi, extracting with ethanol at 30deg.C under 30MPa for 2 hr, leaching for 5 times, filtering to obtain solid, and volatilizing the liquid phase to obtain extract A; the solids were then mixed according to 1g: mixing 100mL of water at 60deg.C, stirring for 2h, filtering to obtain solid, naturally drying the liquid phase to obtain extract B, and mixing extract A and extract B to obtain fructus Ligustri Lucidi extract;
(2) Adding the glossy privet fruit extract into a fermentation medium, then inoculating 1vol% of lactobacillus, fermenting for 120 hours at 25-35 ℃, sterilizing, centrifuging the obtained mixture in a centrifuge at 3000r/min for 2 hours, and taking a liquid phase as a glossy privet fruit extract fermentation filtrate; wherein the fermentation medium contains 25 parts of glossy privet fruit extract, 10 parts of glucose, 5 parts of fructose, 5 parts of urea and 55 parts of water.
Comparative example 5
Examples of skin care compositions, methods of making and using the same, differ from example 1 only in that the aloe vera extract is replaced with a commercially available witch hazel extract.
Comparative example 6
Examples of skin care compositions, methods of making the same, and uses thereof, differ from example 1 only in that the aloe vera extract is replaced with commercially available hyaluronic acid.
Comparative example 7
Examples of skin care compositions, methods of making and using the same, differ from example 1 only in that the glossy privet fruit extract fermentation filtrate is replaced with a commercially available camellia seed extract.
Comparative example 8
A skin care composition, a preparation method and an application example thereof are different from the example 1 only in that the glossy privet fruit extract fermentation filtrate is replaced by a tea seed extract fermentation filtrate prepared by fresh and dried tea seeds according to the same extraction and fermentation method.
Comparative example 9
Examples of skin care compositions, methods of making and using the same, differ from example 1 only in that sodium lauroyl sarcosinate is replaced with sodium myristoyl sarcosinate.
Comparative example 10
Examples of skin care compositions, methods of making and using the same, differ from example 1 only in that sodium lauroyl sarcosinate is replaced with sodium palmitoyl glycinate.
Comparative example 11
Examples of skin care compositions, methods of making the same, and applications thereof, differ from example 1 only in that the ammonium acryloyldimethyl taurate/VP copolymer is replaced with a dimethicone/vinyl dimethicone crosspolymer.
Effect example 1
To verify the mildness of the skin care cleansing milk prepared from each high performance skin care composition of the present invention, each example product was subjected to an acute eye irritation test: taking New Zealand rabbits of biological technology limited company of Shaanxi, testing according to chapter 2015 of cosmetic safety technical Specification, checking two eyes of the New Zealand rabbits with sodium fluorescein for 24 hours before starting to confirm that eyes are normal, and then respectively taking 0.1g of the products prepared in each example into conjunctiva bags of one eye of the animal, so that the upper eyelid and the lower eyelid are closed for 1s to 30s, washing with water, and taking the eyes of the other side as blank control; the test was performed at 1h, 24h, 48h, 72h, day 4 and day 7 after the dropping test, and if the stimulus response did not occur for 72h, the test was terminated, and if the stimulus was found to occur, the test was not recovered for 7 days, and the test was considered to have the stimulus.
The animals were evaluated for the highest integral of the stimulus response and recovery time at 24h, 48h or 72h, respectively, after dosing, the cornea, iris or conjunctiva.
The results show that the integral evaluation of the products of each example is 0, indicating that the products of each example are non-irritating.
Subsequently, each product was allowed to stand for 1 month, and the same test was repeated, and the result was the same as the initial result, indicating that the mildness of each product had long-lasting effect.
Effect example 2
In order to verify the oil control property and long-acting oil control property of the skin care cleansing cream prepared by each high-performance skin care composition of the invention, each example product and comparative example product were subjected to an inhibition test of 5α -reductase (the enzyme can excessively secrete oil from sebaceous glands), and the test method is as follows: taking 5α -reductase provided by university of Guangdong medical science as an experimental object, (1) a sample tube: mixing 1mL of the product of the example or the comparative example, 1mL of enzyme solution, 1mL of NADPH and 1mL of testosterone in a test tube, taking 200 mu L of the mixture in a 96-well ELISA plate by a pipette, making three samples in parallel, and placing the samples into an ELISADetecting by a meter (BioTekSynergy LX), measuring absorbance at 340mm, and taking average value to obtain A 0 Incubating the sample at 37deg.C for 20min, repeatedly measuring, and taking average value to obtain A 20 The method comprises the steps of carrying out a first treatment on the surface of the (2) enzyme tube: mixing 1mLPBS solution, 1mL enzyme solution, 1mL NADPH and 1mL testosterone in a test tube, taking 200 mu L of the mixture in a 96-hole ELISA plate by a pipette, making three parallel samples, placing the samples into an ELISA instrument (BioTekSynergy LX) for detection, measuring the absorbance at 340mm, taking an average value to obtain A Enzyme 0 Incubating the sample at 37deg.C for 20min, repeatedly measuring, and taking average value to obtain A Enzyme 20 The method comprises the steps of carrying out a first treatment on the surface of the Blank and positive control are simultaneously made, and the additive of the positive control is finasteride with the concentration of 2.5mmol/L.
The inhibition ratio of 5α -reductase of each sample was calculated as: inhibition (%) =100 [1- (a) 0 -A 20 ）/（A Enzyme 0 -A Enzyme 20 ）。
The results are shown in Table 2. It can be seen that the inhibition rate of the products of each embodiment can be maintained to be more than 90%, and the comparative products corresponding to the glossy privet fruit active substances prepared by different preparation methods and the products prepared by different active ingredients can not achieve the corresponding effects.
Subsequently, the products of each example and comparative example were allowed to stand at 42℃for 72 hours while applying a fluorescent lamp (the sample was left open under the fluorescent lamp), and whether or not the appearance of the products had oil-water separation, precipitation, thinning or discoloration phenomenon was observed, and then the same test was performed according to the above-described method, and the results are shown in Table 3.
The results show that the products of the examples still have good stability and oil control properties under hot and light environments, while the products of the comparative examples, especially the products employing surfactants and thickeners outside the limits of the present invention, exhibit phenomena such as particle precipitation and discoloration, and at the same time the oil control effect is significantly reduced, failing to maintain long-term efficacy.
Subsequently, the products of each example and comparative example were allowed to stand at room temperature of 25℃for 3 months, and whether the appearance of the products had oil-water separation, precipitation, thinning or discoloration phenomenon was observed, and then the same test was conducted in accordance with the above-described method, and the results are shown in Table 4.
TABLE 2
TABLE 3 Table 3
TABLE 4 Table 4
As can be seen from table 4, similar to the photo-thermal resistance experiment, the product of each example has no obvious change of the oil control effect compared with the initial state, which indicates that the product has ideal oil control long-term effect, wherein according to example 1, example 4 and examples 8 to 12, the jojoba seed extract in the product has no great improvement of the oil control effect, but the stability of the active substance of the jojoba seed extract may affect the oil control long-term effect of the product, and the stability of the extract prepared by the specific ionic liquid process is optimal. The obvious oil control effect attenuation of the comparative example products also appears, which indicates that the oil control active ingredients in the comparative example products are lost or deteriorated in the standing period of 3 months, and even the products have particle agglomeration phenomenon and discoloration phenomenon due to the conversion of active substances, and the appearance is influenced.
Effect example 3
In order to verify the moisturizing property, long-acting moisturizing stability and actual use oil control effect of the skin care cleansing emulsion prepared by the high-performance skin care composition, a volunteer actual use test is adopted, and the test method comprises the following steps: screening a plurality of volunteers with 20-30 years old, no facial skin diseases and allergic medical history of cosmetic skin care products, respectively adopting CornomemerCM 82 skin moisture probes and German CK skin fat tester SebumemerSM 815 to test the moisture content and the fat content of the cheek parts of each volunteer (the cheek part is cleaned by clean water, the test area is 2 multiplied by 2 cm), screening 230 volunteers with the moisture content and the fat content close to each other, dividing the volunteers into 23 groups, namely 10 for men and women, respectively corresponding to the skin care facial cleaner used for left face and face cleaning by using each example and comparative example, adopting fingers for evenly rubbing for 2-3 min during use, adopting two instruments for further recording the moisture content and the fat content of the cheeks at two sides as initial values; after standing at room temperature and normal pressure for 3 hours, the moisture content and the oil content of the cheeks at both sides were further recorded again by using two instruments, and then the results of the moisture and oil change rates of the products of each example and comparative example after 2 hours of use were recorded as shown in table 5, wherein the skin moisture content change rate (%) = (initial moisture content value-initial moisture content after use)/initial moisture content value×100%, the skin oil content change rate (%) = (initial oil content after use-initial oil content value)/initial oil content value×100%, and the average value of each group was finally calculated as statistics.
TABLE 5
As can be seen from the table, after the product of each embodiment of the invention is used, the moisturizing effect of the facial skin of a user is obviously enhanced, the minimum change rate of 1.22% of skin moisture can be maintained after 3 hours, and meanwhile, the product has instant oil control effect, and the oil growth rate is reduced by about 100%.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. The high-performance skin care composition is characterized by comprising the following components in parts by weight:
1-1.5 parts of glossy privet fruit extract fermentation filtrate, 0.1-0.3 part of aloe extract, 1-3 parts of acrylamide dimethyl taurate/VP copolymer and 8-10 parts of N-amido surfactant;
the glossy privet fruit extract fermentation filtrate is obtained by fermenting glossy privet fruit extract by lactobacillus;
the fructus Ligustri Lucidi extract is obtained by supercritical carbon dioxide extraction of fructus Ligustri Lucidi.
2. The high performance skin care composition of claim 1, wherein said N-amido surfactant is at least one of sodium lauroyl sarcosinate, sodium lauroyl glutamate.
3. The high performance skin care composition of claim 1, wherein said glossy privet fruit extract is prepared by a process comprising: crushing the cleaned and dried glossy privet fruits, placing the crushed glossy privet fruits into an extraction kettle containing 1L of supercritical carbon dioxide, and extracting for 2-4 hours at 25-35 ℃ and 20-40 MPa to obtain the glossy privet fruit extract.
4. The high performance skin care composition of claim 1, wherein the preparation method of the fermentation filtrate of the glossy privet fruit extract comprises the following steps: adding the glossy privet fruit extract into a fermentation medium, then inoculating lactobacillus, fermenting for 80-120 hours at 25-35 ℃, sterilizing, centrifuging, and removing solids to obtain the glossy privet fruit extract fermentation filtrate.
5. The high performance skin care composition according to claim 1, wherein the components of the high performance skin care composition further comprise 0.1 to 0.3 parts of jojoba seed extract, wherein the jojoba seed extract is obtained by extracting jojoba seeds from an ionic liquid.
6. The high performance skin care composition of claim 5, wherein said jojoba seed extract is prepared by a process comprising: crushing jojoba seeds, and mixing the crushed jojoba seeds with an ionic liquid according to the mass ratio of (1-3): (18-22) mixing, carrying out ultrasonic treatment for 20-30 min, carrying out solid phase separation, and carrying out decolorization treatment on the obtained liquid phase to obtain the jojoba seed extract.
7. The high performance skin care composition of claim 6, wherein the ionic liquid is a mixture of glycine and alanine in a mass ratio of (0.8-1.2): (0.8-1.2).
8. A high performance skin care cleansing cream comprising the high performance skin care composition of any one of claims 1 to 7.
9. The high-performance skin-care facial cleanser according to claim 8, which comprises the following components in parts by weight, based on 100 parts:
8-12 parts of glycerin, 1-1.5 parts of glossy privet fruit extract fermentation filtrate, 0.1-0.3 part of aloe extract, 1-3 parts of acrylamide-dimethyl taurate/VP copolymer, 1-3 parts of disodium cocoate monoethanolamide sulfosuccinate, 1-3 parts of corn starch, 8-10 parts of N-amido surfactant, 0.1-0.3 part of jojoba seed extract, 0.1-0.2 part of polyglycerol-0.5 part of sodium alginate, 0.1-0.5 part of p-hydroxyacetophenone, 0.1-0.5 part of hexanediol and the balance of water.
10. The method for preparing the high-performance skin-care facial cleanser according to claim 9, which comprises the following steps:
adding proper water into the ammonium acryloyldimethyl taurate/VP copolymer, disodium cocoanut oleate monoethanolamide sulfosuccinate, corn starch, N-amido surfactant and polyglycerol-10, and uniformly mixing at 90-95 ℃ to obtain solution A;
adding proper water into glycerol, sodium alginate, p-hydroxyacetophenone and hexanediol, and uniformly mixing to obtain solution B;
and mixing and stirring the solution A and the solution B at 50-60 ℃ for 20-30 min, cooling, and then adding the glossy privet fruit extract fermentation filtrate, the aloe extract and the jojoba seed extract, and continuously and uniformly mixing to obtain the high-performance skin-care facial cleanser.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311589160.XA CN117281762B (en) | 2023-11-27 | 2023-11-27 | High-performance skin care composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311589160.XA CN117281762B (en) | 2023-11-27 | 2023-11-27 | High-performance skin care composition and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117281762A true CN117281762A (en) | 2023-12-26 |
| CN117281762B CN117281762B (en) | 2024-03-08 |
Family
ID=89248495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311589160.XA Active CN117281762B (en) | 2023-11-27 | 2023-11-27 | High-performance skin care composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117281762B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118141718A (en) * | 2024-02-04 | 2024-06-07 | 广州美兮生物科技有限公司 | Plant oil control composition and application thereof in cosmetics |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309348A (en) * | 2016-09-18 | 2017-01-11 | 诺斯贝尔化妆品股份有限公司 | Pure-amino-acid mild foam cleansing cream with rice fermentation products |
| CN107468599A (en) * | 2017-10-09 | 2017-12-15 | 广西三椿生物科技有限公司 | A kind of tea seed cake hand cleanser and preparation method |
| KR101901670B1 (en) * | 2018-07-04 | 2018-09-28 | 주식회사 아미코스메틱 | A cosmetic compositon for anti-pollution containing extracts of ligustrum lucidum |
| CN109199982A (en) * | 2018-11-02 | 2019-01-15 | 曾日威 | A kind of amino acid moisturizing face cleaning cream and preparation method thereof |
| CN111184773A (en) * | 2020-01-21 | 2020-05-22 | 广东药科大学 | A kind of Ligustrum lucidum extract and its application in the preparation of 5α-reductase inhibitor |
| CN114732847A (en) * | 2022-04-19 | 2022-07-12 | 赵鸿斌 | Oil-control anti-alopecia composition, oil-control anti-alopecia product and preparation method thereof |
| CN116270289A (en) * | 2023-02-03 | 2023-06-23 | 完美（广东）日用品有限公司 | Ionic gel composition containing hydrolyzed actin and preparation method thereof |
-
2023
- 2023-11-27 CN CN202311589160.XA patent/CN117281762B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309348A (en) * | 2016-09-18 | 2017-01-11 | 诺斯贝尔化妆品股份有限公司 | Pure-amino-acid mild foam cleansing cream with rice fermentation products |
| CN107468599A (en) * | 2017-10-09 | 2017-12-15 | 广西三椿生物科技有限公司 | A kind of tea seed cake hand cleanser and preparation method |
| KR101901670B1 (en) * | 2018-07-04 | 2018-09-28 | 주식회사 아미코스메틱 | A cosmetic compositon for anti-pollution containing extracts of ligustrum lucidum |
| CN109199982A (en) * | 2018-11-02 | 2019-01-15 | 曾日威 | A kind of amino acid moisturizing face cleaning cream and preparation method thereof |
| CN111184773A (en) * | 2020-01-21 | 2020-05-22 | 广东药科大学 | A kind of Ligustrum lucidum extract and its application in the preparation of 5α-reductase inhibitor |
| CN114732847A (en) * | 2022-04-19 | 2022-07-12 | 赵鸿斌 | Oil-control anti-alopecia composition, oil-control anti-alopecia product and preparation method thereof |
| CN116270289A (en) * | 2023-02-03 | 2023-06-23 | 完美（广东）日用品有限公司 | Ionic gel composition containing hydrolyzed actin and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 伍钦: "氨基酸工艺学 第二版", 华南理工大学出版社, pages: 323 - 5 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118141718A (en) * | 2024-02-04 | 2024-06-07 | 广州美兮生物科技有限公司 | Plant oil control composition and application thereof in cosmetics |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117281762B (en) | 2024-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103565729B (en) | Condensation and preparation method thereof is repaired in a kind of black Fructus Lycii moisturizing | |
| CN103845272B (en) | Earth-worm extractive as raw material with resisting age of skin effect and its preparation method and application | |
| CN102883733A (en) | AGE production inhibitor | |
| JP7315985B2 (en) | Soap composition using mountain ginseng and soap containing the same | |
| CN113717297B (en) | A kind of rose polysaccharide and its preparation method and application | |
| CN117281762B (en) | High-performance skin care composition and preparation method and application thereof | |
| CN115137673A (en) | Fermented cosmetic composition and preparation method and application thereof | |
| CN110420143B (en) | A kind of condensate containing nine-pin perfume lotus extract and preparation method thereof | |
| CN105640834B (en) | An anti-wrinkle and oil-removing film skin care product containing theabrownin and preparation method thereof | |
| JP2004346045A (en) | Cosmetic additive, bathing agent and health food containing sake lees extract obtained in brewing of sake using deep seawater | |
| CN110151813A (en) | A kind of Codonopsis pilosula extract and its preparation method and application | |
| CN114557927B (en) | Yeast essence water composition, yeast essence water, and preparation method and application thereof | |
| CN101249059A (en) | Moisture-keeping face pack and method of preparing the same | |
| CN105380887A (en) | Purely-natural moisture-retaining toner and preparation method thereof | |
| CN113425662A (en) | Hyaluronic acid and dendrobium officinale yeast fermentation product composition and cosmetic | |
| CN108451863A (en) | A kind of 48 hours facial treatment essence water of long-acting moisturizing | |
| CN118267339A (en) | Preparation and application of nourishing and anti-wrinkle face cream | |
| CN114989324B (en) | A kind of preparation method and application of black garlic polysaccharide | |
| CN114469817B (en) | Pore-shrinking composition and preparation method and application thereof | |
| CN110613663A (en) | Skin repairing composition, skin care product and preparation method thereof | |
| CN107485598B (en) | It is a kind of to thicken pearl toner and preparation method thereof certainly | |
| JP7378217B2 (en) | Cornflower fermented liquid and its manufacturing method, and cosmetics | |
| CN113750017A (en) | Method for preparing dendrobium nobile skin care product with whitening effect | |
| JP4013390B2 (en) | Moisturizing cosmetics | |
| CN107213029A (en) | A kind of moisturizing toner for adding low-temperature superoxide dismutase and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |