CN117074500A - Blood sample analysis module - Google Patents

Abstract

The application provides a blood sample analysis module, which comprises a shell and a wall assembly, wherein a cavity is arranged in the shell, and a first through hole, a second through hole and a third through hole are formed in the shell; the enclosure component is arranged in the cavity and is contacted with the cavity to form a standard cavity and a contrast cavity, the first through hole, the second through hole and the standard cavity are communicated, and the third through hole is communicated with the contrast cavity; the cavity walls of the standard cavity and the control cavity are respectively provided with an electrode assembly; the periphery side in the standard chamber and/or the contrast chamber of enclosure subassembly is equipped with first pipeline and second pipeline, and first pipeline embedding first through-hole, second pipeline embedding second through-hole, and first pipeline and second pipeline all communicate standard chamber. According to the blood sample analysis module provided by the embodiment of the application, the standard cavity and the control cavity are formed by arranging the enclosing wall component in the shell, and the first pipeline and the second pipeline which are communicated with the standard cavity are arranged on the enclosing wall component, so that external liquid of the blood sample analysis module can flow into and out of the standard cavity from the first pipeline and the second pipeline, and repeated measurement is realized.

Description

Blood sample analysis module

Technical Field

The application relates to the technical field of medical instruments, in particular to a blood sample analysis module.

Background

In medical diagnosis, pairSome index determination of blood samples is important in medical diagnostics and therapy, such as pH, hematocrit, ion concentration (K+, na+, cl-, ca) ₂ (+) glucose, lactic acid, and O ₂ 、CO ₂ Partial pressure, etc.

The blood gas biochemical test card is widely used in the medical industry, integrates biochemical test electrodes, and performs test liquid (blood) test after cleaning by cleaning liquid and calibration by calibration liquid. The waste liquid in the test process is stored in the test card, however, based on the limited capacity in the test card, the test card can generally only complete the measurement of single round or few rounds, the measurement times are limited, and the improvement of the test efficiency is not facilitated.

Disclosure of Invention

The application aims to provide a blood sample analysis module to solve the defect that a blood gas biochemical test card can only finish single-round or very few-round measurement.

The embodiment of the application provides a blood sample analysis module, which comprises a shell and a wall assembly, wherein a cavity is arranged in the shell, and a first through hole, a second through hole and a third through hole are formed in the shell; the enclosure component is arranged in the cavity and is contacted with the cavity to form a standard cavity and a contrast cavity, the first through hole, the second through hole and the standard cavity are communicated, and the third through hole is communicated with the contrast cavity; the cavity walls of the standard cavity and the control cavity are respectively provided with an electrode assembly; the periphery side of the standard cavity and/or the contrast cavity of the enclosure assembly is provided with a first pipeline and a second pipeline, the first pipeline is embedded into the first through hole, the second pipeline is embedded into the second through hole, and the first pipeline and the second pipeline are both communicated with the standard cavity.

According to the blood sample analysis module provided by the embodiment of the application, the enclosure wall assembly is arranged in the cavity in the shell to form the standard cavity and the contrast cavity, the first pipeline and the second pipeline which are communicated with the standard cavity are arranged on the enclosure wall assembly, the first pipeline is embedded into the first through hole of the shell, the second pipeline is embedded into the second through hole of the shell to be communicated with the inside and the outside of the shell, so that external liquid of the blood sample analysis module can flow into and out of the standard cavity from the first pipeline and the second pipeline, and the external liquid or liquid which is pre-accommodated in the blood sample analysis module can flow into the contrast cavity from the third through hole. Meanwhile, the cavity walls of the standard cavity and the control cavity are respectively provided with an electrode assembly, so that the blood sample analysis module can complete corresponding measurement operation, and liquid in the standard cavity can not be stored in the blood sample analysis module after measurement is completed, so that the volume of the blood sample analysis module can be greatly reduced. The liquid in the standard cavity can flow into and flow out of the blood sample analysis module through the first pipeline and the second pipeline respectively, so that the blood sample analysis module can realize repeated measurement for many times, the measurement times of the blood sample analysis module are greatly improved, the blood sample analysis module is not required to be replaced frequently, and the testing efficiency is high.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below. It is evident that the drawings in the following description are only some embodiments of the present application and that other drawings may be obtained from these drawings without inventive effort for a person of ordinary skill in the art.

FIG. 1 is a schematic diagram of a blood sample analysis module according to some embodiments of the present application;

FIG. 2 is a schematic diagram showing the structural separation of the blood sample analysis module in the embodiment of FIG. 1;

FIG. 3 is a schematic cross-sectional view of a blood sample analysis module according to some embodiments of the present application;

FIG. 4 is a schematic view of the structure of a wall assembly according to some embodiments of the application;

FIG. 5 is a schematic cross-sectional view of the enclosure assembly of the embodiment of FIG. 4 taken along the direction A-A;

FIG. 6 is a schematic view of the structure of a first housing in some embodiments of the application;

FIG. 7 is a schematic diagram of another cross-sectional configuration of a blood sample analysis module according to some embodiments of the present application;

FIG. 8 is a schematic view of the structure of the first housing in other embodiments of the application;

FIG. 9 is a schematic diagram of a portion of a blood sample analysis module according to some embodiments of the application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. It will be apparent that the described embodiments are only some, but not all, embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.

As used herein, a "blood sample analysis module" may also be referred to as a "blood gas biochemical test card" or a "test card". The blood sample analysis module can be matched with blood gas analysis equipment to measure PH value, hematocrit, ion concentration (K+, na+, cl-, ca) in blood sample ₂ (+) glucose, lactic acid, and O ₂ 、CO ₂ Partial pressure, etc. The blood sample analysis module can generally utilize an electrochemical method or an alternating current impedance method to complete the parameter measurement.

As used herein, the "blood gas analysis device" may also be referred to as a "blood gas analyzer" or a "blood gas biochemical analyzer", which utilizes a blood gas analysis technique. The blood gas analysis technique is applied to blood gas analysis equipment, and can be used for measuring H+ concentration in blood sample and gas dissolved in blood (mainly CO ₂ 、O ₂ Etc.) and other parameters, etc., to understand the respiratory function and the acid-base equilibrium state of the human body, it can directly reflect the pulmonary ventilation function and the acid-base equilibrium state thereof, and the adopted specimen is usually a blood sample.

Referring to fig. 1, fig. 1 is a schematic diagram of a blood sample analysis module 100 according to some embodiments of the present application, wherein the blood sample analysis module 100 may generally include a housing 10 and a wall assembly 30.

The housing 10 has a cavity 101 therein, and the enclosure assembly 30 is disposed in the cavity 101 and contacts the cavity 101 to form a standard cavity 301 and a control cavity 302. The housing 10 is further provided with a first through hole 110, a second through hole 120 and a third through hole 130, the first through hole 110, the second through hole 120 being in communication with the standard chamber 301, the third through hole 130 being in communication with the control chamber 302.

The external liquid of the blood sample analysis module 100 can flow into and out of the standard cavity 301 from the first through hole 110 and the second through hole 120, and the external liquid or the liquid previously contained in the blood sample analysis module 100 can flow into the control cavity 302 from the third through hole 130. Further, the walls of both the standard chamber 301 and the control chamber 302 are provided with electrode assemblies 50 to enable the blood sample analysis module 100 to perform the corresponding measurement operations. It can be understood that the external liquid can be a cleaning liquid, a calibration liquid, a test liquid, and the like, and the external liquid flows into the standard cavity 301 from the outside of the blood sample analysis module 100 to complete the operations of cleaning, calibrating, testing, and the like, and the liquid in the standard cavity 301 can flow out of the blood sample analysis module 100 after the measurement is completed, so that the liquid cannot be stored in the blood sample analysis module 100, and the volume of the blood sample analysis module 100 can be greatly reduced. The liquid in the standard cavity 301 can flow into and out of the blood sample analysis module 100, so that the blood sample analysis module 100 can realize repeated measurement for a plurality of times, the measurement times of the blood sample analysis module 100 are greatly improved, the blood sample analysis module 100 is not required to be replaced frequently, and the measurement efficiency is high.

In one embodiment, the electrode assembly 50 generally includes a first set of test electrodes 51 exposed in a standard chamber 301 and a second set of test electrodes 52 exposed in a control chamber 302.

In an embodiment, the housing 10 may further be provided with a fourth through hole 140 communicating with the cavity 101, and the fourth through hole 140 is not communicated with the standard cavity 301 and the reference cavity 302. The electrode assembly 50 may further include a third test electrode set 53 exposed in the fourth through hole 140, i.e., the third test electrode set 53 may be exposed to the outside of the blood sample analysis module 100 through the fourth through hole 140, thereby enabling the blood sample analysis module 100 to implement signal connection with the blood gas analysis device through the third test electrode set 53 to conduct signals related to the test. The first test electrode group 51 and the second test electrode group 52 are respectively in signal connection with the third test electrode group 53.

Further, the standard chamber 301 and/or the reference chamber 302 of the enclosure assembly 30 are provided with a first pipe 310 and a second pipe 320 on the peripheral side, the first pipe 310 is embedded in the first through hole 110, the second pipe 320 is embedded in the second through hole 120, and the first pipe 310 and the second pipe 320 are both communicated with the standard chamber 301, so that external liquid of the blood sample analysis module 100 can flow into and out of the standard chamber 301 from the first pipe 310 and the second pipe 320. Preferably, the perimeter side of the standard cavity 301 of the enclosure assembly 30 is provided with a first conduit 310 and a second conduit 320.

It will be appreciated that in embodiments of the present application, all directional indications (such as up, down, left, right, front, rear … …) are merely used to explain the relative positional relationship, movement, etc. between the components in a particular gesture (as shown in the figures), and that if the particular gesture changes, the directional indication changes accordingly.

Referring to fig. 2 in combination, fig. 2 is a schematic diagram showing a split structure of the blood sample analysis module 100 in the embodiment of fig. 1, and the housing 10 generally includes a first housing 11 and a second housing 12 disposed on one side of the first housing 11. The first housing 11 may be connected to the second housing 12 by screwing, plugging, buckling, bonding, welding, or the like, and forms a cavity 101 by being surrounded by the first housing and the second housing. Of course, in other embodiments, the first housing 11 and the second housing 12 may be of unitary construction.

The first housing 11 may be made of a hard material such as plastic, resin, polymer material, or the like. For example, the first case 11 may be made of ABS (Acrylonitrile Butadiene Styrene plastic, acrylonitrile butadiene styrene), PDMS (Polydimethylsiloxane), PC (Polycarbonate), PMMA (Polymethyl methacrylate ), PS (General purpose polystyrene, polystyrene), PP (Polypropylene), COC (copolymers of cycloolefin, cyclic olefin copolymer), or the like, and may be manufactured by injection molding, numerical control machining, or 3D printing.

The material of the second housing 12 may be the same as or different from that of the first housing 11. Preferably, the second housing 12 may be a circuit board provided with the electrode assembly 50, that is, the circuit board is provided with a first test electrode set 51, a second test electrode set 52 and a third test electrode set 53, wherein the first test electrode set 51 and the second test electrode set 52 are disposed on the same side of the circuit board, that is, the second housing 12; the third test electrode set 53 and the first test electrode set 51 may be disposed on the same side of the second housing 12 as the circuit board, or may be disposed on opposite sides of the second housing 12.

Wherein, the first through hole 110 and the second through hole 120 respectively penetrate through the second housing 12 to communicate with the standard cavity 301, and the third through hole 130 penetrates through the first housing 11 to communicate with the contrast cavity 302.

Referring to fig. 3, fig. 3 is a schematic cross-sectional structure of a blood sample analysis module 100 according to some embodiments of the present application, two opposite sides of a first housing 11 are respectively provided with a first accommodating cavity 11a and a second accommodating cavity 11b, and a second housing 12 is at least partially embedded in the first accommodating cavity 11a and is enclosed with the first housing 11 to form a cavity 101. In other words, a first accommodating cavity 11a is disposed on a side of the first housing 11 close to the second housing 12, and a second accommodating cavity 11b is disposed on a side of the first housing 11 away from the second housing 12. The enclosure assembly 30 is disposed between the first housing 11 and the second housing 12 and abuts against opposite sides of the cavity 101 to form a standard cavity 301 and a reference cavity 302, i.e. opposite sides of the enclosure assembly 30 abut against the first housing 11 and the second housing 12 to form the standard cavity 301 and the reference cavity 302, respectively.

Preferably, the second housing 12 is embedded in the first accommodating cavity 11a, and the outer periphery of the second housing 12 is matched with the shape of the cavity wall of the first accommodating cavity 11 a. In an embodiment, the second housing 12 may be connected and fixed to the cavity wall of the first accommodating cavity 11a by a connection manner such as a screw connection, a plug connection, a buckle connection, an adhesive connection, a welding connection, or the like. For example, at least one assembly structure (such as a positioning column, a positioning hole, etc.) is disposed on a wall of the first accommodating cavity 11a, and a connection structure (such as a positioning column, a positioning hole, etc.) adapted to the positioning structure is disposed on the second housing 12. The fitting structure and the connecting structure cooperate to achieve fitting connection of the cavity wall of the first housing cavity 11a with the second housing 12. Preferably, the assembly structure and the connection structure may be provided in a foolproof manner to avoid the reverse installation phenomenon when the second housing 12 is assembled to the first housing 11.

Wherein, the third through hole 130 penetrates through the cavity wall of the second accommodating cavity 11b, and the control cavity 302 and the second accommodating cavity 11b are communicated through the third through hole 130. Preferably, the contrast chamber 302 is disposed on a chamber wall of the second accommodating chamber 11b adjacent to the first accommodating chamber 11a, and the third through hole 130 penetrates the chamber wall of the second accommodating chamber 11b adjacent to the first accommodating chamber 11a to communicate the contrast chamber 302 with the second accommodating chamber 11b. The fourth through hole 140 penetrates the first housing 11 to communicate with the first accommodating chamber 11a, and the fourth through hole 140 is not communicated with the standard chamber 301 and the reference chamber 302.

Preferably, the shapes of the first through hole 110, the second through hole 120, the third through hole 130, and the fourth through hole 140 may be circular, rectangular, polygonal, etc., without being particularly limited. The first through hole 110 and the second through hole 120 penetrate through the second housing 12 at intervals, and the axes of the first through hole 110 and the second through hole 120 are substantially parallel and are arranged at intervals. The third through hole 130 and the fourth through hole 140 penetrate through the cavity wall of the first accommodating cavity 11a at intervals, and are communicated with the first accommodating cavity 11a, and the axial lines of the third through hole 130 and the fourth through hole 140 are arranged in parallel at intervals. Of course, in some embodiments, the axes of the first through hole 110, the second through hole 120, the third through hole 130, and the fourth through hole 140 are substantially parallel. It should be understood that the use of the term "substantially, generally" in the present disclosure in terms of a numerical quantity or other quantifiable relationship (e.g., perpendicularity or parallelism) should be understood to indicate a quantity of + -10%. Thus, for example, lines that are substantially parallel to each other may be at an angle between 0 ° and 10 ° to each other.

It should be noted that the terms "first," "second," and the like herein are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features.

Referring now to fig. 4 and 5, fig. 4 is a schematic diagram illustrating the structure of enclosure assembly 30 according to some embodiments of the application, and fig. 5 is a schematic diagram illustrating the cross-sectional structure of enclosure assembly 30 along direction A-A according to the embodiment of fig. 4. Wherein the wall assembly 30 generally comprises a first wall 30a and a second wall 30b, the first wall 30a abutting against opposite sides of the cavity 101 to form a standard cavity 301, the second wall 30b abutting against said opposite sides of the cavity 101 to form a contrast cavity 302, the liquids in the standard cavity 301 and the contrast cavity 302 being not in communication with each other.

Specifically, the opposite sides of the first enclosure wall 30a respectively collide with the first housing 11 and the second housing 12 to form the standard chamber 301, and the opposite sides of the second enclosure wall 30b respectively collide with the first housing 11 and the second housing 12 to form the contrast chamber 302. The first surrounding wall 30a is provided with a first duct 310 and a second duct 320 on the peripheral side. Preferably, the first duct 310 and the second duct 320 are disposed on one side of the first enclosure wall 30a that abuts against the second housing 12.

Wherein, the first pipe 310 and the second pipe 320 are arranged at two ends of the first surrounding wall 30a, are communicated with the standard cavity 301, and are not communicated with the control cavity 302. The first enclosure wall 30a and the second enclosure wall 30b are disposed between the first housing 11 and the second housing 12, that is, the first housing 11 and the second housing 12 cooperatively sandwich the first enclosure wall 30a and the second enclosure wall 30b. The first wall 30a and the second wall 30b may be fastened to the first housing 11 and/or the second housing 12 by screwing, plugging, snapping, welding, bonding, or the like.

The first surrounding wall 30a is substantially annular and surrounds the first set of test electrodes 51 such that the first set of test electrodes 51 is exposed to the standard chamber 301. The second enclosure wall 30b is generally annular and surrounds the second set of test electrodes 52 such that the second set of test electrodes 52 is exposed to the control chamber 302.

The first pipe 310 and the second pipe 320 are disposed on the same side of the first enclosure wall 30a and respectively penetrate through the second housing 12. Wherein the first pipe 310 is embedded in the first through hole 110 and is in interference fit with the inner wall of the first through hole 110 to realize sealing; the second pipe 320 is embedded in the second through hole 120 and is interference fit with the inner wall of the second through hole 120 to achieve sealing.

In one embodiment, the wall assembly 30 may be made of a material having a certain elasticity, such as rubber, silicone, or the like. For example, the enclosure assembly 30 is made of silicone rubber, and the first enclosure wall 30a, the second enclosure wall 30b, the first conduit 310, and the second conduit 320 may be formed by an integral molding process (e.g., injection molding). Of course, in other embodiments, the first enclosure wall 30a, the second enclosure wall 30b, the first conduit 310, and the second conduit 320 may be separately formed and assembled into the enclosure assembly 30, which is not described in detail.

Preferably, the enclosure assembly 30 is made of rubber, silicone, or other elastic material, so that the first housing 11 and the second housing 12 can seal the standard cavity 301 and the reference cavity 302, respectively, by interference fit when the enclosure assembly 30 is clamped.

In an embodiment, the first pipe 310 is formed with a liquid inlet 311, the second pipe 320 is formed with a liquid outlet 321, and the liquid inlet 311 and the liquid outlet 321 are respectively communicated with the standard cavity 301. The inlet 311 generally includes a first inlet section 3111 and a second inlet section 3112, where the first inlet section 3111 is communicated with the standard cavity 301, and the second inlet section 3112 is disposed at an end of the first inlet section 3111 facing away from the standard cavity 301. The outlet 321 generally comprises a first outlet segment 3211 and a second outlet segment 3212, which are connected, wherein the first outlet segment 3211 is communicated with the standard cavity 301, and the second outlet segment 3212 is arranged at the end of the first outlet segment 3211 facing away from the standard cavity 301. Preferably, the first inlet port section 3111 has a substantially uniform aperture in the axial direction thereof, and the second inlet port section 3112 has a gradually increasing aperture in the axial direction thereof in a direction away from the first inlet port section 3111, i.e., the second inlet port section 3112 is substantially horn-shaped. The first outlet hole segments 3211 have substantially uniform apertures along their axes, and the second outlet hole segments 3212 have progressively larger apertures along their axes in a direction away from the first outlet hole segments 3211, i.e. the second outlet hole segments 3212 are substantially trumpet-shaped. It will be appreciated that the trumpet-shaped second inlet section 3112 facilitates docking with an external liquid conduit, and the trumpet-shaped second outlet section 3212 facilitates docking with an external liquid conduit.

Referring to fig. 6, fig. 6 is a schematic structural diagram of the first housing 11 according to some embodiments of the present application. The enclosure assembly 30 generally includes a first enclosure wall 30a that interfaces with opposite sides of the cavity 101 to form a standard cavity 301 and a second enclosure wall 30b that interfaces with the opposite sides of the cavity 101 to form a control cavity 302. At least one cavity wall of the two opposite sides of the cavity 101 is provided with a limiting piece 150, and the enclosing wall assembly 30 is sleeved on the limiting piece 150 to limit the enclosing wall assembly 30.

Taking the example that the limiting member 150 is disposed on the cavity wall of the first accommodating cavity 11a, the limiting member 150 may be a plurality of limiting columns protruding on the cavity wall of the first accommodating cavity 11a, and the first surrounding wall 30a and the second surrounding wall 30b are sleeved on the plurality of limiting columns to realize limiting. Of course, in other embodiments, the limiting member 150 may be a limiting wall surrounding the standard cavity 301 and the contrast cavity 302, where the limiting wall cooperates with the cavity wall of the first accommodating cavity 11a to form a limiting groove, and the first surrounding wall 30a and the second surrounding wall 30b are embedded in the limiting groove to implement limiting.

Referring to fig. 7 and 8, fig. 7 is a schematic cross-sectional view of a blood sample analysis module 100 according to some embodiments of the present application, and fig. 8 is a schematic structural view of a first housing 11 according to other embodiments of the present application. The enclosure assembly 30 generally includes a first enclosure wall 30a that interfaces with opposite sides of the cavity 101 to form a standard cavity 301 and a second enclosure wall 30b that interfaces with the opposite sides of the cavity 101 to form a control cavity 302. At least one of the opposite sides of the cavity 101 is provided with a first accommodating groove 1011 for limiting the first surrounding wall 30a and a second accommodating groove 1012 for limiting the second surrounding wall 30b. The first enclosure wall 30a is at least partially embedded in the first accommodating groove 1011, and the second enclosure wall 30b is at least partially embedded in the second accommodating groove 1012, so as to avoid dislocation of the enclosure assembly 30 during assembly.

It should be understood that, the first enclosure wall 30a and the second enclosure wall 30b are at least partially embedded in the first accommodating groove 1011 and the second accommodating groove 1012, so that not only the dislocation phenomenon of the enclosure wall assembly 30 during assembly can be avoided, but also the tightness of the standard cavity 301 and the contrast cavity 302 can be improved, and the liquid leakage phenomenon can be avoided. Wherein, the shape of the first accommodating groove 1011 is matched with the outer periphery of the first surrounding wall 30a, and the shape of the second accommodating groove 1012 is matched with the outer periphery of the second surrounding wall 30b.

In one embodiment, the first enclosure wall 30a and the second enclosure wall 30b are integrally formed, and at this time, the first accommodating groove 1011 and the second accommodating groove 1012 are in communication. Of course, in other embodiments, the first enclosure wall 30a and the second enclosure wall 30b may be separate structures, and in this case, the first accommodating groove 1011 and the second accommodating groove 1012 are not communicated with each other.

The first pipe 310 and the second pipe 320 are disposed at a side of the first enclosure wall 30a away from the first accommodating groove 1011 and are respectively communicated with the first accommodating groove 1011, so that the first pipe 310 and the second pipe 320 can be communicated with the standard cavity 301 through the first accommodating groove 1011.

Specifically, the bottom wall of the first accommodating groove 1011 is provided with a first fluid groove 1011a communicating with the liquid inlet 311 and a second fluid groove 1011b communicating with the liquid outlet 321, the first fluid groove 1011a communicates with the liquid inlet 311 and the standard cavity 301, respectively, and the second fluid groove 1011b communicates with the liquid outlet 321 and the standard cavity 301, respectively. In other words, the liquid inlet 311 may communicate with the standard chamber 301 via the first fluid tank 1011a, and the liquid outlet 321 may communicate with the liquid outlet 321 and the standard chamber 301 via the second fluid tank 1011 b. That is, the first pipe 310 may be in communication with the standard chamber 301 via the first fluid tank 1011a, and the second pipe 320 may be in communication with the standard chamber 301 via the second fluid tank 1011 b.

Wherein the first enclosing wall 30a and the second enclosing wall 30b are arranged side by side on the cavity wall of the first accommodating cavity 11 a. When the first casing 11 and the second casing 12 cooperate to clamp the first enclosing wall 30a and the second enclosing wall 30b, the first casing 11 and the second casing 12 cooperate to clamp the first enclosing wall 30a, so that two opposite sides of the first enclosing wall 30a are respectively in interference fit with the first casing 11 and the second casing 12 to realize a sealing effect; the first housing 11 and the second housing 12 cooperatively clamp the second enclosure wall 30b such that opposite sides of the second enclosure wall 30b are in interference fit with the first housing 11 and the second housing 12, respectively, to achieve a sealing effect.

Meanwhile, the first pipeline 310 and the standard cavity 301 are respectively communicated with the first fluid groove 1011a, and the second pipeline 320 and the standard cavity 301 are respectively communicated with the second fluid groove 1011b, so that the liquid outside the blood sample analysis module 100 can flow into the first fluid groove 1011a through the first pipeline 310 and then flow into the standard cavity 301 through the first fluid groove 1011 a; and so that the liquid in the standard chamber 301 can flow into the second conduit 320 via the second fluid slot 1011b and then flow to the outside of the blood sample analysis module 100 via the second conduit 320.

As described above, the third through hole 130 penetrates the cavity wall of the second housing cavity 11b. Further, the third through hole 130 penetrates through the bottom wall of the second accommodating groove 1012, so that the control chamber 302 can communicate with the second accommodating chamber 11b through the third through hole 130. I.e. the liquid in the second receiving chamber 11b can flow into the control chamber 302 via the third through-hole 130. Preferably, the second enclosure wall 30b is disposed around the periphery of the third through hole 130 to enhance the sealing effect of the control chamber 302.

It will be appreciated that when the blood sample analysis module 100 is used in conjunction with a blood gas analysis device, the test fluid, calibration fluid, and cleaning fluid may flow through the standard chamber 301 to perform the corresponding testing, calibration, and cleaning operations. It will be appreciated that the second housing 12 may be provided with at least one electrode for performing electrochemical analysis, which may be distributed over the walls of the standard chamber 301 and the control chamber 302, and that the liquid flowing into the standard chamber 301 and the control chamber 302 covers the electrodes, whereby the pH, hematocrit, ion concentration, lactic acid, and O may be achieved by means of electrical signals on the electrodes ₂ 、CO ₂ And measuring parameters such as partial pressure and the like.

The blood sample analysis module provided by the application has the advantages that before the measurement of the test liquid is carried out, the cleaning liquid and the calibration liquid respectively flow into the standard cavity to finish the cleaning and calibration operation, and after the operation is finished, the blood sample analysis module flows out of the standard cavity and cannot be stored in the blood sample analysis module. The test liquid flows into the standard cavity to finish parameter measurement, and flows out of the standard cavity to the blood sample analysis module after measurement is finished, so that the test liquid cannot be stored in the blood sample analysis module. The blood sample analysis module provided by the application has the advantages that the waste liquid recovery container is not required to be arranged in the blood sample analysis module, the volume of the blood sample analysis module can be greatly reduced, and the light and thin blood sample analysis module is facilitated to be realized. In addition, the test liquid, the cleaning liquid and the calibration liquid respectively flow through the standard cavity to finish corresponding operation, and then flow out of the blood sample analysis module from the standard cavity, so that repeated measurement can be realized by the blood sample analysis module, the measurement times of the blood sample analysis module are greatly improved, the blood sample analysis module is not required to be replaced frequently, and the test efficiency can be further improved.

Referring to fig. 9, fig. 9 is a schematic diagram of a portion of a blood sample analysis module 100 according to some embodiments of the present application, wherein fig. 9 illustrates a fitting manner of the enclosure assembly 30 and the second housing 12. The first enclosure wall 30a and the second enclosure wall 30b of the enclosure assembly 30 are disposed side by side on the second housing 12 and cooperate with the second housing 12 and the first housing 11 to form a control chamber 302 of the standard chamber 301. As described above, the second housing 12 may be a circuit board, on which the first test electrode set 51, the second test electrode set 52, and the third test electrode set 53 are disposed at intervals.

Wherein the first set of test electrodes 51 is configured for measuring an electrochemical parameter of the liquid in the reference chamber 301 and the second set of test electrodes 52 is configured for feeding back the potential of the first set of test electrodes 51 to ensure a stable potential of the first set of test electrodes 51.

In particular, the first set of test electrodes 51 may comprise at least one test electrode exposed on the cavity wall of the standard cavity 301 for obtaining electrochemical parameters of the liquid in the standard cavity 301. The second set of test electrodes 52 may include at least one reference electrode exposed on the chamber wall of the control chamber 302 for acquiring electrode potential. The first test electrode set 51 and the second test electrode set 52 are respectively connected with the third test electrode set 53, so that the acquired signal data is sent to the blood gas analysis device for further processing by the third test electrode set 53.

Based on this, the control chamber 302 is configured to hold a liquid such as a reference liquid, and there is no need to additionally provide a container for holding a liquid such as a reference liquid, and the overall structure is simple and the assembly is convenient. The second housing 12 is further provided with a salt bridge 54 penetrating the standard chamber 301 and the control chamber 302 to reduce the liquid connection potential. Can be used forIt is understood that the insertion of a salt bridge between the two solutions to replace the original direct contact of the two solutions, reduces and stabilizes the liquid junction potential (when two electrolytes of different compositions or activities are in contact, the separation of positive and negative charges at the solution junction due to the difference in ion migration rate of positive and negative ions through the interface forms an electric double layer, so that the resulting potential difference is referred to as the liquid junction diffusion potential, abbreviated as the liquid junction potential), and minimizes the liquid junction potential to be nearly eliminated. I.e., to prevent ions in the standard chamber 301 from diffusing into the control chamber 302 to affect the potential of the reference electrode. For example, when the reference solution in the control chamber 302 is a saturated KCI solution, its concentration is typically as high as 4.2mol/dm ³ When a salt bridge is inserted into the interface between two electrolyte solutions of low concentration, two interfaces are created, and the K+ and CI-out-diffusion in the salt bridge becomes the main stream of ion diffusion at these two interfaces. Because the diffusion rates of K+ and CI-are similar, the liquid connection potential generated by the contact of a salt bridge and two solutions is very small, and the directions of the K+ and the CI-are opposite, so that the K+ and the CI-are mutually offset and then reduced to 1-2 mV. The electrolyte in the salt bridge is selected in such a way that it has a high concentration, has a nearly equal number of positive and negative ion transitions, and does not chemically react with the liquid in the standard chamber 301. The reference solution is usually a saturated solution of KCI, NH4NO3 and KNO 3.

Namely, by arranging the salt bridge 54 to penetrate through the standard cavity 301 and the control cavity 302, the liquid in the standard cavity 301 and the control cavity 302 is ensured to be not mixed, and the potential influence on the reference electrode is reduced.

It will be appreciated that the second receiving chamber 11b is configured to receive a reference liquid or a container or the like containing a reference liquid, and that the reference liquid in the second receiving chamber 11b can flow into the control chamber 302 via the third through-hole 130, which can increase the number of uses of the blood sample analysis module.

According to the blood sample analysis module provided by the application, the standard cavity and the contrast cavity are formed by arranging the enclosing wall component in the cavity in the shell, and the first pipeline and the second pipeline which are communicated with the standard cavity are arranged on the enclosing wall component, the first pipeline is embedded into the first through hole of the shell, the second pipeline is embedded into the second through hole of the shell so as to be communicated with the inside and the outside of the shell, so that external liquid of the blood sample analysis module can flow into and out of the standard cavity from the first pipeline and the second pipeline, and external liquid or liquid which is pre-accommodated in the blood sample analysis module can flow into the contrast cavity from the third through hole. Meanwhile, the cavity walls of the standard cavity and the control cavity are respectively provided with an electrode assembly, so that the blood sample analysis module can complete corresponding measurement operation, and liquid in the standard cavity can not be stored in the blood sample analysis module after measurement is completed, so that the volume of the blood sample analysis module can be greatly reduced. The liquid in the standard cavity can flow into and flow out of the blood sample analysis module through the first pipeline and the second pipeline respectively, so that the blood sample analysis module can realize repeated measurement for many times, the measurement times of the blood sample analysis module are greatly improved, the blood sample analysis module is not required to be replaced frequently, and the testing efficiency is high.

It should be noted that the terms "comprising" and "having," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those listed steps or elements but may alternatively include other steps or elements not listed or inherent to such process, method, article, or apparatus.

The foregoing description is only a partial embodiment of the present application, and is not intended to limit the scope of the present application, and all equivalent devices or equivalent processes using the descriptions and the drawings of the present application or directly or indirectly applied to other related technical fields are included in the scope of the present application.

Claims (13)

1. A blood sample analysis module, comprising:

the shell is internally provided with a cavity and is provided with a first through hole, a second through hole and a third through hole;

the enclosing wall assembly is arranged in the cavity and is in contact with the cavity to form a standard cavity and a contrast cavity, the first through hole, the second through hole and the standard cavity are communicated, and the third through hole is communicated with the contrast cavity; the cavity walls of the standard cavity and the control cavity are respectively provided with an electrode assembly;

the periphery side of the standard cavity and/or the contrast cavity of the enclosure assembly is provided with a first pipeline and a second pipeline, the first pipeline is embedded into the first through hole, the second pipeline is embedded into the second through hole, and the first pipeline and the second pipeline are both communicated with the standard cavity.

2. The blood sample analysis module of claim 1, wherein the enclosure assembly includes a first enclosure wall and a second enclosure wall, the first enclosure wall abutting opposite sides of the cavity to form the standard cavity, the second enclosure wall abutting opposite sides of the cavity to form the control cavity, the standard cavity and the control cavity being non-communicating with each other.

3. The blood sample analysis module of claim 2, wherein at least one of the two opposing faces has a wall with a stop, the wall assembly being disposed over the stop.

4. The blood sample analysis module of claim 2, wherein one of the two opposing surfaces has a cavity wall with a first receiving groove for limiting the first wall and a second receiving groove for limiting the second wall, the first wall being at least partially embedded in the first receiving groove, and the second wall being at least partially embedded in the second receiving groove.

5. The blood sample analysis module of claim 4, wherein the first enclosure wall and the second enclosure wall are of unitary construction.

6. The blood sample analysis module of claim 4, wherein the first and second receiving grooves are in communication.

7. The blood sample analysis module of claim 4, wherein the first conduit and the second conduit are disposed on a side of the first enclosure wall facing away from the first receiving slot and are in communication with the first receiving slot, respectively.

8. The blood sample analysis module of claim 7, wherein the bottom wall of the first housing groove is provided with a first fluid groove and a second fluid groove, the first conduit communicates with the standard chamber via the first fluid groove, and the second conduit communicates with the standard chamber via the second fluid groove.

9. The blood sample analysis module of claim 1, wherein the housing comprises a first housing and a second housing disposed on one side of the first housing, wherein a first receiving cavity and a second receiving cavity are disposed on opposite sides of the first housing, respectively; the second shell is at least partially embedded in the first accommodating cavity and is matched with the first shell to form the cavity.

10. The blood sample analysis module of claim 9, wherein the first and second through holes extend through the second housing to communicate with the standard chamber, respectively.

11. The blood sample analysis module of claim 9, wherein the third through-hole extends through a wall of the second receiving chamber, the control chamber and the second receiving chamber being in communication through the third through-hole.

12. The blood sample analysis module of claim 9, wherein the second housing is a circuit board, the electrode assembly includes a first set of test electrodes disposed on the circuit board and a second set of test electrodes, the first set of test electrodes being exposed to the standard chamber and the second set of test electrodes being exposed to the control chamber.

13. The blood sample analysis module of claim 12, wherein the electrode assembly further comprises a third set of test electrodes disposed on the circuit board, the first housing having a fourth through hole in communication with the first receiving cavity, the third set of test electrodes being exposed to the exterior of the blood sample analysis module via the fourth through hole.