CN116983230A - No-blocking wash-free ethanol gel after drying and preparation method thereof - Google Patents
No-blocking wash-free ethanol gel after drying and preparation method thereof Download PDFInfo
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- CN116983230A CN116983230A CN202311249159.2A CN202311249159A CN116983230A CN 116983230 A CN116983230 A CN 116983230A CN 202311249159 A CN202311249159 A CN 202311249159A CN 116983230 A CN116983230 A CN 116983230A
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- gel
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 159
- 238000001035 drying Methods 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 66
- 230000000903 blocking effect Effects 0.000 claims abstract description 23
- 150000002148 esters Chemical class 0.000 claims description 29
- 239000003921 oil Substances 0.000 claims description 24
- 235000019198 oils Nutrition 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 23
- 229920002125 Sokalan® Polymers 0.000 claims description 22
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 21
- 229960001631 carbomer Drugs 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000008367 deionised water Substances 0.000 claims description 16
- 229910021641 deionized water Inorganic materials 0.000 claims description 16
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 11
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000011148 porous material Substances 0.000 claims description 8
- -1 fatty acid ester Chemical class 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- 235000019489 Almond oil Nutrition 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 239000008168 almond oil Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3
- 229960000281 trometamol Drugs 0.000 claims description 3
- 239000010497 wheat germ oil Substances 0.000 claims description 3
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 13
- 230000006698 induction Effects 0.000 abstract description 6
- 230000002411 adverse Effects 0.000 abstract description 4
- 230000006378 damage Effects 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract description 2
- 239000007924 injection Substances 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 60
- 235000019441 ethanol Nutrition 0.000 description 41
- 210000003491 skin Anatomy 0.000 description 26
- 230000000052 comparative effect Effects 0.000 description 16
- 239000002562 thickening agent Substances 0.000 description 8
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 238000012795 verification Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 241000700605 Viruses Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940049964 oleate Drugs 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229920013818 hydroxypropyl guar gum Polymers 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a washing-free ethanol gel without blocking holes after drying and a preparation method thereof, which comprises the following components in percentage by weight: the invention has the advantages that when the liquid outlet is matched with an automatic induction liquid outlet machine for use, gel residues which are dry and hard to accumulate are few, even residues attached to the inner wall of the liquid outlet can be smoothly discharged along with the next liquid outlet, the discharged residues can not cause irritation or injury to skin, and adverse effects caused by disordered injection of the liquid outlet of the machine can be effectively avoided.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a washing-free ethanol gel without blocking holes after drying and a preparation method thereof.
Background
60% -75% (v/v) ethanol solution has wide virus killing capacity, so that the ethanol solution is widely applied to various places, but high-concentration ethanol solution has high risk. In order to facilitate the safe use of consumers, a plurality of wash-free disinfection gels with the ethanol content of 75% (v/v) or the ethanol content of 50% -75% (v/v) compounded with other polyols or bactericides appear on the market, so that people can disinfect hands at any time under the anhydrous condition, and virus invasion is prevented. However, in some public places, such as hospital guide, clinic, ICU room, collective office, business super cash desk, bank window, etc., even in the home, people need to receive non-contact anti-virus gel to prevent cross infection between people. Thus, non-contact automatic liquid-sensing machines have been developed.
When the traditional high-ethanol-content washing-free gel is matched with an automatic induction liquid outlet machine, gel residues generally exist at a liquid outlet of the machine. Residual gel can dry and knot at the liquid outlet along with the volatilization of solvent (mainly ethanol and water), and the dry and knot is accumulated for a plurality of times, so that the liquid outlet of a machine is easily blocked, and the liquid is not smooth and even sprayed in an unoriented way. If the ethanol gel solution is sprayed on the body or eyes of a user, the use experience of the product is affected on one hand, and the safety risk is brought on the other hand. The main reasons are as follows: the higher the ethanol content, the more thickening agents (e.g., carbomers, cellulose gums, chitosan, hydroxypropyl guar, etc.) that need to be added to the formulation to achieve a convenient viscosity, which can introduce more or less film forming and adhesion. In addition, the high content of ethanol can dehydrate the skin epidermis to cause skin dryness while sterilizing, therefore, it is common to add moisturizing agents such as glycerin, sodium hyaluronate, polyethylene glycol and the like into the formula, and the addition of the moisturizing ingredients further increases the film forming property or the adhesiveness of the gel. So the dry matters of the common wash-free ethanol gel are sticky, elastic, agglomerated or firm in shape, and the dry matters of the ethanol gel block the liquid outlet of the machine, so that the liquid is not smooth and even sprayed in an unoriented manner. Therefore, there is an urgent need to develop a wash-free ethanol gel without blocking holes after drying and a preparation method thereof to solve the above technical problems.
In view of this, the present invention has been made.
Disclosure of Invention
The invention aims to provide the wash-free ethanol gel without blocking holes after drying and the preparation method thereof, and the wash-free ethanol gel has less gel residues dried and accumulated at a liquid outlet when being matched with an automatic induction liquid outlet machine, can be smoothly discharged along with the next liquid outlet even if residues attached to the inner wall of the liquid outlet are arranged, can not cause irritation or damage to skin, can effectively avoid adverse effects caused by random spraying of the liquid outlet of the machine due to blockage, has wide application prospect, and is beneficial to popularization and application.
In order to achieve the purpose, the invention provides a washing-free ethanol gel without blocking holes after drying, which comprises the following components in percentage by weight: 0.1-0.3% carbomer, 55-70% ethanol, 0.2-2.0% liquid water-soluble skin care oil ester, and proper amount of alkaline pH regulator to reach pH value of 5.5-7.5 for the whole system of components, and deionized water for the rest.
Preferably, the carbomer is U10, U20, U21, U30, 940, 941, 980, 934 or 981.
Preferably, the liquid water-soluble skin care oil ester is an oligoglycerol fatty acid ester or a polyethylene glycol fatty acid ester.
Preferably, the liquid water-soluble skin care oil ester is glycerol polyether-8 wheat germ oil ester, glycerol polyether-8 almond oil ester, PEG-7 cocoyl glyceride or PEG-7 caprylic/capric glyceride.
Preferably, the alkaline pH regulator is NaOH, KOH, triethanolamine, aminomethylpropanol or tromethamine.
The invention also provides a preparation method of the wash-free ethanol gel without blocking holes after drying, which comprises the following steps:
s1: dispersing 0.1-0.3% carbomer in deionized water, stirring and dispersing until no white powder or obvious large granule exists;
s2: adding 55-70% ethanol, and stirring until no granule exists;
s3: adding 0.2-2.0% of liquid water-soluble skin care oil ester into the above components, and stirring uniformly;
s4: while stirring the above components, adding alkaline pH regulator until the system becomes transparent gel, and controlling pH value within 5.5-7.5.
Preferably, in S1, the stirring is performed by using an electric stirrer or a magnetic stirrer.
Preferably, in S2, stirring is performed by using a homogenizer, an electric stirrer or a magnetic stirrer.
Preferably, in S3, the stirring is performed by using an electric stirrer or a magnetic stirrer.
The wash-free ethanol gel without blocking holes after drying and the preparation method thereof have the following beneficial effects.
1. When the invention is matched with an automatic induction liquid outlet machine, gel residues which are dried and bound at the liquid outlet are less, the accumulation is difficult, even residues attached to the inner wall of the liquid outlet can be smoothly discharged along with the next liquid outlet, the discharged residues can not cause irritation or damage to the skin, and adverse effects caused by disordered spraying of the liquid outlet of the machine due to blockage can be effectively avoided.
2. In a great deal of experimental researches, the inventor of the invention accidentally finds that the thickening agent carbomer, the liquid water-soluble skin care oil ester and the alkaline pH regulator are simultaneously applied to the wash-free ethanol gel, so that remarkable synergistic effect can be generated, the gel liquid outlet is not blocked after being dried, and unexpected technical effects are generated.
Detailed Description
The invention is further described below in connection with specific examples and implementations to aid in understanding the context of the invention.
The invention provides a no-pore blocking wash-free ethanol gel after drying, which comprises the following components in percentage by weight: 0.1-0.3% carbomer, 55-70% ethanol, 0.2-2.0% liquid water-soluble skin care oil ester, and proper amount of alkaline pH regulator to reach pH value of 5.5-7.5 for the whole system of components, and deionized water for the rest. The carbomer is U10, U20, U21, U30, 940, 941, 980, 934 or 981. The liquid water-soluble skin care oil ester is an oligoglycerol fatty acid ester or a polyethylene glycol fatty acid ester. Preferably, the liquid water-soluble skin care oil ester is glycerol polyether vegetable oleate, polyethylene glycol vegetable oleate or polyethylene glycol carboxylic acid glyceride (medium and short chain with carboxylic acid groups of less than 10 carbons). The liquid water-soluble skin care oil ester is glycerol polyether-8 wheat germ oil ester, glycerol polyether-8 almond oil ester, PEG-7 cocoyl glyceride or PEG-7 caprylic/capric glyceride. The four raw materials are derived from natural vegetable oil which is friendly to skin, or caprylic acid/capric acid glyceride which has a structure similar to that of triglyceride of skin, have the function of moisturizing skin, are commonly used as a fat-forming agent or a humectant in skin care products, and are mild and non-irritating raw materials. The alkaline pH regulator is NaOH, KOH, triethanolamine, aminomethylpropanol or tromethamine.
The invention also provides a preparation method of the wash-free ethanol gel without blocking holes after drying, which comprises the following steps:
s1: dispersing 0.1-0.3% carbomer in deionized water, and stirring and dispersing by an electric stirrer or a magnetic stirrer until no white powder or no obvious large particle exists;
s2: adding 55-70% ethanol, and stirring with homogenizer, electric stirrer or magnetic stirrer until no granule exists;
s3: adding 0.2-2.0% of liquid water-soluble skin care oil ester into the above components, and stirring with electric stirrer or magnetic stirrer;
s4: while stirring the above components, adding alkaline pH regulator until the system becomes transparent gel, and controlling pH value within 5.5-7.5.
Example 1:
the wash-free ethanol gel without blocking holes after drying consists of the following components in percentage by weight: 0.1% carbomer U30, 55% absolute ethanol, 0.2% PEG-7 coco glyceride, 0.018% aminomethylpropanol, the balance deionized water.
Example 2:
the wash-free ethanol gel without blocking holes after drying consists of the following components in percentage by weight: 0.28% carbomer U30, 68% absolute ethanol, 0.3% PEG-7 coco glyceride, 0.055% aminomethylpropanol, and the balance deionized water.
Example 3:
the wash-free ethanol gel without blocking holes after drying consists of the following components in percentage by weight: 0.3% carbomer U30, 70% absolute ethanol, 2.0% PEG-7 coco glyceride, 0.058% aminomethylpropanol, and the balance deionized water.
Example 4:
the wash-free ethanol gel without blocking holes after drying consists of the following components in percentage by weight: 0.3% carbomer U30, 55% absolute ethanol, 2.0% PEG-7 coco glyceride, 0.058% aminomethylpropanol, and the balance deionized water.
Comparative example 1:
the wash-free ethanol gel which is easy to plug holes after being dried comprises the following components in percentage by weight: 0.28% carbomer U30, 68% absolute ethanol, 0.055% aminomethylpropanol, and the balance deionized water.
Comparative example 2:
the wash-free ethanol gel which is easy to plug holes after being dried comprises the following components in percentage by weight: 0.4% hydroxyethyl cellulose, 55% absolute ethyl alcohol and the balance deionized water.
Comparative example 3:
the wash-free ethanol gel which is easy to plug holes after being dried comprises the following components in percentage by weight: 0.8% hydroxypropyl guar gum, 68% absolute ethyl alcohol, a proper amount of citric acid (with pH value adjusted to 5.0-6.5) and the balance of deionized water.
Comparative example 4:
the wash-free ethanol gel which is easy to plug holes after being dried comprises the following components in percentage by weight: 0.1% carbomer U30, 55% absolute ethanol, 0.058% aminomethylpropanol, and the balance deionized water.
Comparative example 5:
the wash-free ethanol gel which is easy to plug holes after being dried comprises the following components in percentage by weight: 0.3% carbomer U30, 70% absolute ethyl alcohol, 0.058% aminomethyl propanol, and the balance deionized water.
Comparative example 6:
the wash-free ethanol gel which is easy to plug holes after being dried comprises the following components in percentage by weight: 0.3% carbomer U30, 55% absolute ethyl alcohol, 0.058% aminomethyl propanol, and the balance deionized water.
The formulations of examples 1-4 and comparative examples 1-6 are shown in tables 1 and 2:
table 1 example formulation
Table 2 comparative example formulation
TABLE 3 description of other ingredients in the formulation that affect gel texture
The components in Table 3 are intended to illustrate the individual effects of the thickener and liquid water-soluble skin care oil ester of the present invention: the carbomer and the alkaline pH regulator are added in a pair according to a specific proportion to achieve a thickening effect to form gel and achieve a safe pH value which accords with skin application. Neither carbomer nor alkaline pH adjusting agent alone forms an ethanol gel that meets the teachings of the present invention. The components in Table 3 are mutually soluble and do not have any thickening properties, so that no matter what operation is carried out, no gel preparation can be formed, but only a mixture containing ethanol can be formed. The formulation without the addition of a thickener (containing a pH adjustor) is not within the scope of the present invention.
Physicochemical tests were conducted on examples 1 to 4 and comparative examples 1 to 6, and the results of the physicochemical tests are shown in Table 4:
TABLE 4 physicochemical experimental results
The results of the above physicochemical experiments show that: the pH values of examples 1-4 and comparative examples 1-6 are between 5.5 and 7.5, so that the requirements of human skin on the pH values can be met, and the viscosity and the state of the wash-free ethanol gel accord with the characteristics of the conventional skin or hand.
Effect verification experiments were performed on examples 1 to 4 and comparative examples 1 to 6, and the verification method is as follows:
(1) 3g of the gel obtained in the above formula was placed in a dish, dried in a forced air drying oven at 50℃for 4 hours, and then taken out to observe the gel dry matter.
(2) 100g of gel obtained by the formula is prepared and put into unified containers, each container is provided with the same hand-washing-free disinfection gel automatic discharging machine, and the normal use of each machine is confirmed before testing.
The testing method comprises the following steps: the 10 sets of machine and gel combination were left to drain 1 time a day in the morning and evening at room temperature. Day 1-5, the test was continued. And stopping the test at the 6 th to the 7 th days, so that the gel liquid remained at the liquid outlet can be dried and bonded fully and naturally. And 4 cycles are continuously performed for 7 days, and the liquid outlet state and the dry state of the liquid outlet of the machine are recorded.
The results of the effect verification experiments are shown in tables 5 and 6:
table 5 example effect verification experiment results
Table 6 comparative example effect verification experiment results
The experimental results of the above effect verification show that: examples 1-4 enable the gel to dry without blocking the machine outlet, and at the same time, the dry product can be washed off smoothly by the gel liquid. And the gel spraying phenomenon occurs after the test for 2-10 days in comparative examples 1-6. Since examples 1 to 4 each contained a water-soluble skin care oil ester in a liquid state, and comparative examples 1 to 6 lacked a water-soluble skin care oil ester in a liquid state. Wherein the thickeners of comparative examples 2, 3 also differ from examples 1-4. Comparative examples 1, 4, 5, and 6 correspond to examples 2, 1, 3, and 4, respectively, for removal of liquid water-soluble skin care oil esters.
From this, it can be seen that the thickener carbomer, the liquid water-soluble skin care oil ester and the alkaline pH regulator are applied to the wash-free ethanol gel at the same time, so that a remarkable synergistic effect is generated, and the gel liquid outlet is not blocked after being dried, so that unexpected technical effects are generated.
The mechanism realized by the invention is described as follows:
(1) In the process of using the gel and the automatic induction liquid outlet machine in a matched manner, a small amount of residual gel is always attached to a liquid outlet of the machine, along with the continuous volatilization of ethanol and water, a thickener in the gel can form an adhesive substance to be attached to the inner wall of the liquid outlet, and a liquid water-soluble skin care oil ester part in the gel is uniformly fused with the thickener, so that the formed adhesive substance is soft and weak, and the residual oil ester is attached to the inner wall of the liquid outlet.
(2) After the repeated 'use-stop-residual gel dry-up' circulation, the adhesive on the inner wall of the liquid outlet gradually increases and even the liquid outlet is stuck.
(3) As the number of the adhesive matters increases, the more liquid oil ester is attached to the inner wall of the liquid outlet, and the better the lubricity is.
(4) Then under the impact force of the gel liquid flowing out and the lubrication action of the liquid oil ester, the film forming property of the adhesive is destroyed by the oil ester, and the adhered adhesive is easy to be washed down, so that no gel spraying phenomenon exists, the adhesive is gradually discharged after the gel liquid flows out for 1-3 times, and the liquid outlet is cleaned again.
When the invention is matched with an automatic induction liquid outlet machine, gel residues which are dried and hard at the liquid outlet are less, and are not easy to accumulate, even residues attached to the inner wall of the liquid outlet can be smoothly discharged along with the next liquid outlet, and the discharged residues can not cause irritation or damage to skin, thereby effectively avoiding adverse effects caused by disordered injection of the liquid outlet of the machine due to blockage, having wide application prospect and being beneficial to popularization and application.
Specific examples are set forth herein to illustrate the invention in detail, and the description of the above examples is only for the purpose of aiding in understanding the core concept of the invention. It should be noted that any obvious modifications, equivalents, or other improvements to those skilled in the art without departing from the inventive concept are intended to be included in the scope of the present invention.
Claims (9)
1. The wash-free ethanol gel without blocking holes after drying is characterized by comprising the following components in percentage by weight: 0.1-0.3% carbomer, 55-70% ethanol, 0.2-2.0% liquid water-soluble skin care oil ester, and proper amount of alkaline pH regulator to reach pH value of 5.5-7.5 for the whole system of components, and deionized water for the rest.
2. The no-pore blocking wash-free ethanol gel of claim 1, wherein the carbomer is U10, U20, U21, U30, 940, 941, 980, 934, or 981.
3. The no-pore blocking wash-free ethanol gel as claimed in claim 1, wherein the liquid water-soluble skin care oil ester is an oligoglycerol fatty acid ester or polyethylene glycol fatty acid ester.
4. The no-pore blocking wash-free ethanol gel after drying according to claim 1, wherein the liquid water-soluble skin care oil ester is glycerol polyether-8 wheat germ oil ester, glycerol polyether-8 almond oil ester, PEG-7 cocoyl glyceride or PEG-7 caprylic/capric glyceride.
5. The no-pore blocking wash-free ethanol gel after drying according to claim 1, wherein the alkaline pH adjuster is NaOH, KOH, triethanolamine, aminomethylpropanol or tromethamine.
6. The preparation method of the wash-free ethanol gel without blocking holes after drying is characterized by comprising the following steps:
s1: dispersing 0.1-0.3% carbomer in deionized water, stirring and dispersing until no white powder or obvious large granule exists;
s2: adding 55-70% ethanol, and stirring until no granule exists;
s3: adding 0.2-2.0% of liquid water-soluble skin care oil ester into the above components, and stirring uniformly;
s4: while stirring the above components, adding alkaline pH regulator until the system becomes transparent gel, and controlling pH value within 5.5-7.5.
7. The method for preparing a no-pore blocking wash-free ethanol gel after drying according to claim 6, wherein in S1, stirring is performed by an electric stirrer or a magnetic stirrer.
8. The method for preparing a no-pore blocking wash-free ethanol gel after drying according to claim 6, wherein in S2, a homogenizer, an electric stirrer or a magnetic stirrer is used for stirring.
9. The method for preparing a no-pore blocking wash-free ethanol gel after drying according to claim 6, wherein in S3, stirring is performed by an electric stirrer or a magnetic stirrer.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003321321A (en) * | 2002-04-30 | 2003-11-11 | Lion Corp | Cosmetic |
| CN102123764A (en) * | 2007-10-30 | 2011-07-13 | Gojo工业公司 | Hydroalcoholic gel compositions for use with dispensers |
| US20200179250A1 (en) * | 2017-04-04 | 2020-06-11 | Gojo Industries, Inc. | Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003321321A (en) * | 2002-04-30 | 2003-11-11 | Lion Corp | Cosmetic |
| CN102123764A (en) * | 2007-10-30 | 2011-07-13 | Gojo工业公司 | Hydroalcoholic gel compositions for use with dispensers |
| US20200179250A1 (en) * | 2017-04-04 | 2020-06-11 | Gojo Industries, Inc. | Methods and compounds for increasing virucidal efficacy in hydroalcoholic systems |
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