CN102123764A - Hydroalcoholic gel compositions for use with dispensers - Google Patents

Abstract

The present invention relates to a hydroalcoholic gel composition comprising greater than about 40% by weight alcohol, polyacrylate thickener and ester anti-blocking agent, based on the total weight of the alcohol composition. The composition is suitable for use in a dispenser with reduced misdirected output when the dispenser is actuated.

Description

Hydroalcoholic gel composition for use with a dispenser

related application

This application claims the benefit of US Provisional Application No. 60/983856, filed October 30, 2007. This application is hereby expressly incorporated by reference.

technical field

The present invention relates to a hydroalcoholic gel composition for use with a dispenser wherein misdirection occurs when the hydroalcoholic gel composition includes a plug-preventing additive The frequency of the splitter output drops.

Background technique

Personal care and hygiene compositions are usually formulated in the form of hydroalcoholic gels. Typically, these products are provided in dispensers. Dispenser outlets, such as nozzles, can become clogged or partially blocked over time as the gel sets to form a deposit on the nozzle. Subsequently, when the dispenser is next used, the clogged nozzle causes the product to be dispensed in the wrong direction. Instead of dispensing the product directly into the user's hand, the product is ejected sideways through a clogged nozzle. A product in the wrong direction can hit walls, clothing, floors and can cause damage to these items or areas.

Therefore, there is a need for hydroalcoholic gel compositions that reduce clogging of dispenser nozzles.

Contents of the invention

One or more embodiments provide a method of reducing the formation of coagulated gel deposits, the method comprising the steps of: combining a C _1-4 alcohol, an effective amount of a polyacrylate thickener, and an anti-blocking additive Forming a dispensable gel composition, wherein the anti-blocking additive comprises an ester having 2-6 ester groups or a polymeric ester comprising at least one ester group, and wherein the composition comprises at least about 40% by weight of said alcohol and less than about 1% by weight of fatty alcohol, petrolatum, mineral oil, or a mixture thereof, all based on the total weight of said dispensable gel composition; and, storing said dispensable gel in a cycle-action In a pump dispenser wherein the formation of coagulated gel deposits is reduced compared to a dispensable gel that does not include an anti-clogging additive.

One or more embodiments of the present invention further provide a method of reducing the frequency of misdirection output from a gel dispenser, said method comprising the steps of: mixing a C _1-4 alcohol, an effective amount of a polyacrylate thickener, and The anti-blocking additives combine to form a dispensable gel composition, wherein the anti-blocking additive comprises an ester having 2-6 ester groups or a polymeric ester comprising at least one ester group, and wherein the composition comprises at least about 40% by weight of said alcohol and less than about 1% by weight of fatty alcohol, petrolatum, mineral oil, or mixtures thereof, all based on the total weight of said dispensable gel composition; and, storing said dispensable gel In a pump dispenser that includes an outlet and operates periodically, the frequency of misdirected outputs is reduced therein as compared to a dispensable gel that does not include an anti-clogging additive.

One or more embodiments of the present invention further provide gel compositions comprising at least about 60% by weight of C _1-4 alcohols (based on the total weight of the gel composition), an effective amount of Polyacrylate thickeners, ester anti-blocking additives (comprising 2-6 ester groups) or polymeric esters (comprising at least one ester group), and less than about 1% by weight of fatty alcohol, petrolatum, mineral oil or Mixtures, all based on the total weight of the gel composition.

Detailed ways

In one or more embodiments, the dispensable hydroalcoholic gel compositions of the present invention include a hydroalcoholic vehicle, a polyacrylate thickener, and an anti-blocking additive. In one or more embodiments, the hydroalcoholic carrier includes water and alcohol.

In one embodiment, the alcohol is a lower alkanol, ie, an alcohol containing 1 to 4 carbon atoms. Typically, these alcohols have antimicrobial properties. Examples of lower alkanols include, but are not limited to, methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol, and mixtures thereof. In one embodiment, the alcohol comprises ethanol.

Generally, the hydroalcoholic gel composition comprises at least about 40 weight percent (wt %) alcohol, based on the total weight of the hydroalcoholic gel composition. In one embodiment, the hydroalcoholic gel composition comprises at least about 45 wt% alcohol, in another embodiment, the hydroalcoholic gel composition comprises at least about 50 wt% alcohol, in another embodiment, the hydroalcoholic gel The composition comprises at least about 60 weight percent alcohol, based on the total weight of the hydroalcoholic gel composition. In some cases more or less alcohol may be required, depending inter alia on the other ingredients employed in the composition and/or their amounts. In some embodiments, the hydroalcoholic gel composition comprises from about 40 wt% to about 98 wt% alcohol, in other embodiments, the hydroalcoholic gel composition comprises from about 45 wt% to about 95 wt% alcohol, In still other embodiments, the hydroalcoholic gel composition comprises from about 50 wt% to about 90 wt% alcohol, in other embodiments, the hydroalcoholic gel composition comprises from about 60 wt% to about 80 wt% alcohol, Based on the total weight of the hydroalcoholic gel composition.

The hydroalcoholic gel composition may include a mixture of C _1-9 alkanols. In one or more embodiments, the hydroalcoholic gel composition includes a mixture of one or more C _1-4 alkanols and one or more C _5-9 alkanols. The mixture may include primary, secondary or tertiary alcohols.

The hydroalcoholic gel can be thickened with polyacrylate thickeners, such as those conventionally available and/or known in the art. Examples of polyacrylate thickeners include carbomers, acrylates/C10-30 alkyl acrylate crosspolymers, copolymers of acrylic acid and alkyl (C5-C10) acrylates, acrylic acid and maleic anhydride copolymers, and mixtures.

In one or more embodiments, the polymeric thickener includes from about 0.5 wt% to about 4 wt% crosslinker. Examples of crosslinking agents include polyalkenyl polyethers.

Acrysol

ICS-1、Polygel

Sokalan

Carbopol

1623、Carbopol695、Ultrez 10和Polygel

DB商品名销售的那些。Commercially available polyacrylate polymers include Carbopol

Acrysol

ICS-1, Polygel

Sokalan

Carbopol

1623. Carbopol 695, Ultrez 10, and Polygel

Those sold under the DB trade name.

In one or more embodiments, the compositions of the present invention include an effective amount of a polymeric thickener to adjust the viscosity of the hydroalcoholic gel to a viscosity in the range of about 1,000 to about 65,000 centipoise. In one embodiment, the viscosity of the hydroalcoholic gel is from about 5,000 to about 35,000, and in another embodiment, the viscosity is from about 10,000 to about 25,000. Viscosity is measured by a Brookfield RV Viscometer using an RV and/or LV Spindle at 22°C +/- 3°C.

As those skilled in the art will recognize, the effective amount of thickening agent will vary depending on a number of factors including the amount of alcohol and other ingredients in the hydroalcoholic gel composition. In one or more embodiments, an effective amount of thickener is at least about 0.01 wt%, based on the total weight of the hydroalcoholic gel composition. In other embodiments, the effective amount is at least about 0.02 wt%, in other embodiments at least about 0.05 wt%, in other embodiments at least about 0.1 wt%. In one embodiment, the effective amount of the thickener is at least about 0.5 wt%, and in another embodiment, at least about 0.75 wt%, based on the total weight of the hydroalcoholic gel. In one or more embodiments, the compositions of the present invention comprise up to about 10% by weight of the total composition of a polymeric thickener. In some embodiments, the amount of thickener is about 0.01 wt% to about 1 wt%, in another embodiment, about 0.02 wt% to about 0.4 wt%, in another embodiment, about 0.05 wt% % - about 0.3 wt%, based on the total weight of the hydroalcoholic gel. In one embodiment, the amount of thickener is from about 0.1 wt% to about 10 wt%, in another embodiment from about 0.5 wt% to about 5 wt%, in another embodiment from about 0.75 wt% to About 2 wt%, based on the total weight of the hydroalcoholic gel.

In one or more embodiments, the hydroalcoholic gel may further include a neutralizing agent. The use of neutralizing agents to form salts of carbomer polymers is well known. Examples of neutralizing agents include amines, alkanolamines, alkanolamides, inorganic bases, amino acids, including their salts, their esters and acyl derivatives.

Examples of common neutralizers are shown in Table 1, along with the preparation of these neutralizers, and recommendations to achieve neutralization (pH 7.0) when the equivalent weight of the polymeric thickener is about 76 +/- 4 Ratio (per part of polymer thickener).

Table 1

In one or more embodiments, the neutralizing agent can be selected based on the amount of alcohol to be gelled. Table 2 gives the neutralizers generally recommended for use in hydroalcoholic systems.

Table 2

The hydroalcoholic gel further includes one or more anti-blocking additives. In general, the additive prevents the hydroalcoholic gel from setting into a solid or semi-solid material that may deposit on surfaces or clog dispenser nozzles. In one or more embodiments, the anti-blocking additive comprises a compound comprising 2-6 ester groups or a polymeric ester comprising at least one ester group. In one embodiment, the anti-blocking additive comprises a monomeric or polymeric diester, triester, tetraester, pentaester, or hexaester, or a polymeric monoester.

In one or more embodiments, the anti-blocking additive includes one or more of the following: C1-C30 alcohol esters of C1-C30 carboxylic acids, ethylene glycol monoesters of C1-C30 carboxylic acids, C1-C30 carboxylic acid Ethylene glycol diester of C1-C30 carboxylic acid propylene glycol monoester, C1-C30 carboxylic acid propylene glycol diester, C1-C30 carboxylic acid monoester and polypropylene glycol polyester, C1-C30 carboxylic acid monoester and polyester Polyesters of propylene glycol, polyesters of C1-C30 carboxylic acid monoesters and C4-C20 alkyl ethers, C1-C30 carboxylic acid monoesters and di-C8-C30 alkyl ethers, and mixtures thereof.

In one or more embodiments, the anti-blocking additive includes one or more of the following: C1-C22 alcohol ester of C1-C22 carboxylic acid, C11-C22 alcohol ester of C3-C10 carboxylic acid, C1-C22 carboxylic acid Ethylene glycol monoester of C1-C22 carboxylic acid ethylene glycol diester, C1-C22 carboxylic acid propylene glycol monoester, C1-C22 carboxylic acid propylene glycol diester, C1-C22 carboxylic acid monoester and polypropylene glycol Polyester, C1-C22 carboxylic acid monoester and polyester of polypropylene glycol, C1-C22 carboxylic acid monoester and C4-C22 alkyl ether polyester, C1-C22 carboxylic acid monoester and di-C8-C22 alkyl Polyesters of ethers, and mixtures thereof.

In one or more embodiments, the esters are formed from any kind of acid and alcohol. In one or more embodiments, at least one of the acid or alcohol includes a fatty chain. In one or more embodiments, the ester is formed from an acid having from about 4 to about 28 carbon atoms and an alcohol having from about 2 to about 22 carbon atoms, and in another embodiment, the ester is formed from acids having about 8 to about 22 carbon atoms and alcohols having about 2 to about 22 carbon atoms.

Examples of ester anti-blocking additives include acetyl tributyl citrate, acetyl triethyl citrate, acetyl triethylhexyl citrate, acetyl trihexyl citrate, butyl benzyl phthalate Formate, Butylphthaloyl Butyl Glycolate, Butyryl Trihexyl Citrate, Dibutyl Adipate, Dibutyl Octyl Malate, Dibutyl Oxalate, Dibutyl Phthalate Dicarboxylate, Dibutyl Sebacate, Dioctyl Adipate, Dicapryl/Capryl Sebacate, Diethylene Glycol Dibenzoate, Diethylene Glycol Diethylhexyl Esters/diisonononanoate, diethylene glycol diisonononate, diethylene glycol abietate, diethylhexyl adipate, diethylhexyl phthalate, diethyl Hexyl Sebacate, Diethyl Hexyl Succinate, Diethyl Hexyl Terephthalate, Diethyl Oxalate, Diethyl Phthalate, Diethyl Sebacate, Diethyl succinate, diisoamyl malate, diisobutyl adipate, diisobutyl maleate, diisobutyl oxalate, diisohexadecyl adipate ester, diisohexadecyl dodecanedioate, diisodecyl adipate, diisononyl adipate, diisohexadecyl adipate, diisooctylmaleic acid ester, diisooctyl sebacate, diisopropyl adipate, diisopropyl oxalate, diisopropyl sebacate, diisopropyl dimer dilinoleate , Diisostearyl adipate, Diisostearyl fumarate, Diisostearyl glutarate, Diisostearyl malate, Diisostearyl sebacate, Dimethyl adipate, Dimethyl oxalate, Dimethyl phthalate, Dioctyl dodecyl adipate, Dioctyl dodecyl dimer dilinoleum Dioctyl dodecyl dodecanedioate, Dioctyl dodecyl fluoroheptyl citrate, Dioctyl dodecyl IPDI, Dioctyl dodecyl lauroyl diacetate Dioctyl dodecyl malate, Dioctyl dodecyl sebacate, Dioctyl dodecyl stearyl glutamate, Dipentaerythritol hexa C5-9 acid Ester, Dipentaerythritol Hexa C5-10 Ester, Dipropyl Oxalate, Pentaerythritol Tetra C5-9 Ester, Pentaerythritol Tetra C5-10 Ester, Tributyl Citrate, Tricapryl/Octyl Trimellitate, triethyl citrate, triethylene glycol dibenzoate, triethylene glycol abietate, triethylhexyl citrate, triethylhexyl trimellitate, three Methylpentyl Dibenzoate, Trimethylpentyl Diisobutyrate, Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Pentahydroxystearate, Polyglyceryl-10 Pentaisostearate, Polyglyceryl-10 Pentalaurate, Polyglyceryl-10 Pentalinoleate, Polyglyceryl-5 Pentamyristate, Polyglyceryl-4-Pentoleate, Polyglyceryl-6 Pentaoleate, Polyglyceryl-10 Penta-Oleate, Polyglyceryl-3 Penta-Rinoleate, Polyglyceryl-6 Penta-Cinoleate, Polyglyceryl-10 Penta-Castor Oil Ester, Polyglyceryl-4 Pentastearate, Polyglyceryl-6 Pentastearate, Polyglyceryl-10 Pentastearate, Sorbitol Polyoxyethylene (20) Ether Penta Isostearate, Sorbitol polyoxyethylene (30) ether pentaisostearate, Sorbitan polyoxyethylene (40) ether pentaisostearate, Sorbitol polyoxyethylene (50) ether pentaisostearate Fatty acid esters, polyoxyethylene (40) sorbitan pentaoleate, sucrose pentaerucate, and triacetylglycerides, combinations thereof.

In one or more embodiments, the anti-blocking additive comprises a polymeric ester. In one embodiment, the polymeric ester comprises a polyether polymer chain and at least one ester group. In one embodiment, the polymeric ester includes two or more ester groups.

In one or more embodiments, the polymer chains include polyethylene glycol (PEG) chains, polypropylene glycol (PPG), or combinations thereof. In one or more embodiments, the polymer chain includes up to about 12 PEG units, PPG units, or combinations thereof. In one or more embodiments, the polymer chain includes up to about 10 PEG units, PPG units, or combinations thereof. In one or more embodiments, the polymer chain includes up to about 8 PEG units, PPG units, or combinations thereof. In one or more embodiments, the polyether polymer chain includes from about 1 to about 12 PPG or PEG units, in other embodiments from about 2 to about 8 PPG or PEG units, or combinations thereof.

Examples of polymeric esters include those that can be represented by the formula:

wherein ^R is a linear or branched alkyl group having from 1 to 28 carbon atoms; each ^R can be the same or different, including polyether chains having from 1 to about 12 PEG or PPG groups or combinations thereof; Each R ³ may be the same or different, include an alkyl or alkylene group having 1 to about 30 carbon atoms, and wherein each R ³ group is attached to R ² via an ether bond.

In one or more embodiments, ^R includes up to about 20 carbon atoms, in other embodiments, ^R includes up to about 10 carbon atoms, in other embodiments, ^R includes up to about 8 carbon atoms . In one or more embodiments, R ³ may be represented by the formula CH ₃ (CH ₂ ) _z O—, wherein in one or more embodiments, z is an integer from 1 to about 21, in other embodiments , is 2 to about 17, and in other embodiments is 3 to about 15.

In one or more embodiments, the polymeric ester may be represented by the formula

Wherein R ⁴ includes straight or branched chain alkyl or alkylene having 1 to about 22 carbon atoms. In one or more embodiments, R ⁴ may be represented by CH ₃ (CH ₂ ) _z -, wherein in one or more embodiments, z is an integer from 1 to about 21, and in other embodiments is 2- Integers from about 17, in other embodiments from 3 to about 15. In one or more embodiments, n is an integer from 1 to about 20, and in other embodiments from 2 to about 10. In one or more embodiments, x is 0, in other embodiments, x is an integer of up to about 12, in other embodiments, an integer of up to about 10, in other embodiments, an integer of up to about 8 integer. In one or more embodiments, y is 0, in other embodiments, y is an integer of up to about 12, in other embodiments is an integer of up to about 10, in other embodiments is an integer of up to about 8 .

Examples of polymeric esters further include those that can be represented by the formula:

wherein R ¹ , R ² and R ³ are as described above.

Examples of polymeric esters include any of the above diesters, triesters, tetraesters, pentaesters, or hexaesters that have been modified to include PPG, PEG, or PPG/PEG polymer chains of suitable length. Specific examples include di-PPG-3-hexadecyl polyoxyethylene (4) ether adipate, di-PPG-2-tetradecyl polyoxyethylene (10) ether adipate, di-PPG - 3-myristyl ether adipate, and PPG-2-myristyl ether propionate. In one or more embodiments, a mixture of one or more polymeric esters and one or more monomeric diesters, triesters, tetraesters, pentaesters, or hexaesters may be employed as the anti-blocking additive.

In one embodiment, the anti-blocking additive is present in an amount (active) of about 0.005 wt% to about 4 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the anti-blocking additive is present in an amount of about 0.01 wt % to about 1 wt %, based on the total weight of the hydroalcoholic gel composition, and in another embodiment, the anti-blocking additive is present in an amount of about 0.02 wt % to about 1 wt % It is present in an amount of about 0.7 wt%, based on the total weight of the hydroalcoholic gel composition.

In one embodiment, the anti-blocking additive is added directly to the hydroalcoholic gel composition. In one or more other embodiments, the anti-blocking additive is added to the hydroalcoholic gel composition in the form of a solution or emulsion. In other words, the anti-blocking additive can be premixed with the carrier to form an anti-blocking additive solution or emulsion, provided the carrier does not adversely affect the anti-caking properties of the hydroalcoholic gel composition. Examples of carriers include water, alcohols, glycols such as propylene glycol or ethylene glycol, ketones, linear and/or cyclic hydrocarbons, triglycerides, carbonates, silicones, alkenes, esters such as acetates, benzoic acid Esters, fatty acid esters, glycerides, ethers, amides, polyethylene glycol and PEG/PPG copolymers, inorganic salt solutions such as saline, and mixtures thereof. It should be understood that when the anti-blocking additive is premixed to form the anti-blocking additive solution or emulsion, the amount of the solution or emulsion added to the hydroalcoholic gel composition is selected so that the amount of the anti-blocking additive falls within the above range.

In one or more embodiments, the balance of the hydroalcoholic gel composition includes water or other suitable solvent. In one embodiment, one or more volatile silicone-based materials are included in the formulation to further assist in the evaporation process. Exemplary volatile silicones have lower heats of vaporization than alcohols. In some embodiments, the use of silicone-based materials can reduce the surface tension of fluid compositions. This provides greater contact with the surface. In one embodiment, a silicone-based material, such as cyclomethicone, trimethylsiloxysilicate, or a combination thereof, may be present at a concentration of about 4 wt % to about 50 wt % , in another embodiment, is included in the formulation at a concentration of about 5 wt % to about 35 wt %, in another embodiment about 11 wt % to about 25 wt %, based on the total weight of the hydroalcoholic gel composition .

The hydroalcoholic gel compositions of the present invention may further comprise a wide range of optional ingredients, provided they do not adversely affect the anti-caking properties of the hydroalcoholic gel composition. CTFA International Cosmetic Ingredient Dictionary and Handbook, Eleventh Edition, 2005 and 2004 CTFA International Buyer's Guide (both of which are hereby incorporated by reference in their entirety) describe various ingredients commonly used in the skin care industry that are suitable for use in the compositions of the present invention. A non-limiting cosmetic and pharmaceutical composition. Non-limiting examples of functional classes of ingredients are described in these documents. Examples of these functional classes include: abrasives, antiacne agents, anticoagulants, antioxidants, binders, biological additives, botanicals, bulking agents, chelating agents, chemical additives; colorants, cosmetic astringents, cosmetic Biological agents, denaturants, pharmaceutical astringents, emulsifiers, external analgesics, film formers, fragrance components, humectants, odor neutralizers, opacifiers, plasticizers, preservatives, propellants, reducing agents, skin Bleaching agents, skin conditioning agents (emollients, humectants, miscellaneous and occlusive agents), skin protectants, solvents, foam boosters, hydrotropes, solubilizers, suspending agents (non-surfactant ), sunscreens, UV absorbers, detackifiers, and tackifiers (aqueous and non-aqueous). Examples of other functional classes of materials useful herein known to those skilled in the art include solubilizers, sequestrants, keratolytics, and the like. In one or more embodiments, one or more ingredients may be encapsulated or microencapsulated. For example, active substances, colourants, fragrances, flavors, botanicals, solids or other synthetic ingredients may be present in the composition in encapsulated form.

Surfactants may be included in hydroalcoholic gel compositions to enhance or alter gel quality and properties, to alter the feel of the final formulation during application and/or drying, to provide persistence or long-term microbial utility, for solubilizing other ingredients such as fragrances or sunscreens, and for irritation relief. Optional surfactants include, but are not necessarily limited to, sulfosuccinates, amine oxides, PEG-80 sorbitan laurate, polyglucosides, alkanolamides, sorbitan derivatives, fatty alcohol ethoxylates , quaternary ammonium compound, amidoamine, sultaine, isothionate (isothiosulfate), sarcosinate (salt), betaine, polysorbate and fatty alcohol polyethylene glycol.

In one or more embodiments, the hydroalcoholic gel composition comprises one or more of the following optional components: glycerin, fragrance, isopropyl myristate, titanium dioxide, aluminum oxide, tocopheryl acetate , Aloe Vera Extract, Dye and Propylene Glycol. In these or other embodiments, the hydroalcoholic gel composition includes one or more auxiliary thickeners, such as cationic polymeric thickeners.

The amount of optional components is not particularly limited so long as the optional components have no detrimental effect on the anti-caking properties of the hydroalcoholic gel composition. In some embodiments, one or more adjuvants may be present in the hydroalcoholic gel composition in an amount of about 0 to about 2 wt%, based on the total weight of the hydroalcoholic gel composition. In other embodiments, one or more adjuvants may be present in the hydroalcoholic gel composition in an amount of about 0.1 to about 1 wt%, based on the total weight of the hydroalcoholic gel composition.

In some embodiments, the hydroalcoholic gel composition includes one or more humectants. Examples of humectants include propylene glycol, dipropylene glycol, hexanediol, 1,4-dihydroxyhexane, 1,2,6-hexanetriol, sorbitol, butylene glycol, propylene glycol such as methylpropylene glycol, dipropylene glycol, tris Ethylene glycol, glycerin (glycerol), polyethylene glycol, ethoxydiethylene glycol, polyethylene sorbitol, and combinations thereof. Other humectants include glycolic acid, glycolate salts, lactate salts, lactic acid, sodium pyrrolidone carboxylate, hyaluronic acid, and chitin, among others. In one embodiment, the humectant is present in an amount of about 0.1 wt% to about 20 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the humectant is present in an amount of about 1 wt % to about 8 wt %, and in another embodiment, in an amount of about 2 wt % to about 3 wt %, based on the total weight of the hydroalcoholic gel composition .

In these or other embodiments, the hydroalcoholic gel composition comprises one or more conditioning or moisturizing esters. Examples of esters include cetyl myristate, cetyl myristate, and other cetyl esters, and isopropyl myristate. In one embodiment, the ester is present in an amount of up to 10 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the ester is present in an amount of about 0.5% to about 5% by weight, and in another embodiment, in an amount of about 1% to about 2% by weight, based on the hydroalcoholic gel combination total weight of the object.

In one or more embodiments, the hydroalcoholic gel composition includes one or more emulsifiers. Examples of emulsifiers include stearyl alcohol, sorbitan oleate trideceth-2, poloxamers, and PEG/PPG-20/6 simethicone. In one embodiment, the emulsifier is present in an amount up to about 10 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the emulsifier is present in an amount of about 0.1 wt % to about 5 wt %, in another embodiment about 0.5 wt % to about 2 wt %, based on the total weight of the hydroalcoholic gel composition .

In one or more embodiments, the hydroalcoholic gel composition includes one or more solubilizers. Examples of solubilizers include PEG-40 hydrogenated castor oil, sorbitan polyoxyethylene (20) ether oleate (polysorbate-80), PEG-80 sorbitan laurate, cetostearyl Oxyethylene (20) ether (ceteareth-20), oleyl polyoxyethylene (12) ether (oleth-20), PEG-4 and propylene glycol. The amount of solubilizing agent is not particularly limited as long as it has no detrimental effect on the anti-caking properties of the hydroalcoholic gel composition.

In one embodiment, alcohol is the only active antimicrobial ingredient incorporated into the composition. In this embodiment, the amount of auxiliary antimicrobial ingredient is less than about 0.5 wt%, and in another embodiment less than about 0.1 wt%, based on the total weight of the hydroalcoholic gel composition. In other embodiments, the composition includes a supplementary antimicrobial agent in addition to the alcohol.

The hydroalcoholic gel compositions of the present invention may optionally further comprise a wide range of topical pharmaceutically active substances, provided they do not adversely affect the anti-caking properties of the hydroalcoholic gel composition.

One or more of the above optional ingredients may be limited for reasons including solubility and aesthetics. In one or more embodiments, the limited amount of optional ingredients is less than about 0.5 wt%, and in another embodiment, less than about 0.1 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the hydroalcoholic gel composition is free of such limited optional ingredients.

One or more of the following components may be limited for reasons including solubility and aesthetics. In one or more embodiments, the amount of fatty alcohol is limited. In one embodiment, the amount of fatty alcohol is less than about 0.5 wt%, in another embodiment less than about 0.1 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the hydroalcoholic gel composition is free of fatty alcohols.

In one or more embodiments, the amount of petrolatum or mineral oil is limited. In one embodiment, the amount of petrolatum or mineral oil is less than about 0.5 wt%, in another embodiment less than about 0.1 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the hydroalcoholic gel composition is free of petrolatum or mineral oil. In these or other embodiments, the total amount of fatty alcohol, petrolatum, and mineral oil is less than about 1 wt%.

In one or more embodiments, the amount of glycerol is limited. In one embodiment, the amount of glycerin is less than about 1 wt%, and in another embodiment, less than about 0.5 wt%, based on the total weight of the hydroalcoholic gel composition. In another embodiment, the hydroalcoholic gel composition is free of glycerin.

Dispensable hydroalcoholic gel compositions can be prepared by simply mixing the components together. The order of addition is not particularly limited. In one embodiment, a hydroalcoholic gel composition is prepared by a process comprising: dispersing a polymeric thickener in alcohol with slow to moderate agitation; adding water; then adding an anti-clogging additive; and mixing until the mixture is homogeneous. In other embodiments, the hydroalcoholic gel composition is prepared by a process comprising: dispersing a polymeric thickener in water with slow to moderate agitation; adding alcohol, anti-clogging additives; and mixing until the mixture is homogeneous . In one or more embodiments, a neutralizing agent is added to the mixture to neutralize the thickener and form a gel. Those skilled in the art will understand that optional ingredients can be added at various points during the mixing process. It should also be understood that gels can be formed without a neutralizing agent if the thickener is one that swells when mixed with water or alcohol.

和TFX^TM获自GOJOIndustries的那些，以及传统的袋在盒中式分配器(bag-in-box dispenser)。分配器实例描述在美国专利5,265,772、5,944,227、6,877,642、7,028,861和U.S公布申请2006/0243740 A1和2006/0124662 A1中，在此全部通过引用结合进来。在一个或多个实施方案中，分配器包括出口比如喷嘴，水醇凝胶组合物通过所述出口分配。The hydroalcoholic gel composition of the present invention may be used in any type of dispenser typically used for gel products, such as pump dispensers. A wide range of pump dispensers are suitable. The pump dispenser can be attached to a bottle or other free-standing container. Pump dispensers can be incorporated into wall mounted dispensers. Pump dispensers can be manually activated with a hand or foot pump, or can be automatically activated. Useful allocators include the names NXT

and TFX ^™ from GOJO Industries, as well as traditional bag-in-box dispensers. Examples of dispensers are described in US Patent Nos. 5,265,772, 5,944,227, 6,877,642, 7,028,861 and US Published Applications 2006/0243740 Al and 2006/0124662 Al, all of which are hereby incorporated by reference. In one or more embodiments, the dispenser includes an outlet, such as a nozzle, through which the hydroalcoholic gel composition is dispensed.

In one or more embodiments, the hydroalcoholic gels of the present invention are dispensed with fewer misdirections than conventional hydroalcoholic gels without an anti-blocking agent. The frequency of misdirection outputs can be determined as a percentage of the total number of dispenser actions. Comparative measurements can be made at various rates of motion. Output targets can be created to distinguish acceptable output from misdirected output. In one or more embodiments, the output target simulates the dispenser user's hand(s). The output target defines the area of acceptable output. In one or more embodiments, when an effective amount of an anti-blocking agent is added to the hydroalcoholic gel composition, the frequency of misdirection outputs can be reduced. In some embodiments, when the dispenser actuation rate is 0.1 actuations per hour, the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle less than 50% of the time. In other embodiments, when the dispenser actuation rate is 0.1 actuations per hour, the dispenser output is located outside of a 2.5 square inch area approximately 3 inches directly below the dispenser nozzle less than 30% of the time. In one or more embodiments, when the dispenser actuation rate is 0.1 actuations per hour, the dispenser output is located less than 20% of the time outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one embodiment, when the dispenser actuation rate is 0.1 actuations per hour, the dispenser output has a frequency of less than 15% outside a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, substantially none of the dispenser output is located outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle when the dispenser actuation rate is 0.1 actuation per hour.

In one or more embodiments, when an effective amount of an anti-blocking agent is added to the hydroalcoholic gel composition, the frequency of misdirected outputs can be reduced. In some embodiments, when the dispenser actuation rate is 0.1 actuations per hour, the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle with less than 10% frequency. In other embodiments, when the dispenser actuation rate is 0.1 actuations per hour, less than 5% of the time the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 0.1 actuations per hour, less than 1% of the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one embodiment, when the dispenser actuation rate is 0.1 actuations per hour, less than 0.5% of the dispenser output will be outside a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, substantially none of the dispenser output is located outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle when the dispenser actuation rate is 0.1 actuation per hour.

In some embodiments, when the dispenser actuation rate is 0.5 actuations per hour, less than 40% of the time the dispenser output will be located outside the 2.5 square inch area approximately 3 inches directly below the dispenser nozzle. In other embodiments, when the dispenser actuation rate is 0.5 actuations per hour, less than 30% of the time, the dispenser output will be outside a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 0.5 actuations per hour, less than 20% of the time, the dispenser output will be outside a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one embodiment, when the dispenser actuation rate is 0.5 actuations per hour, less than 15% of the time the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 0.5 actuations per hour, substantially none of the dispenser output will be located outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle.

In some embodiments, when the dispenser actuation rate is 0.5 actuations per hour, less than 10% of the time, the dispenser output will be outside the 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In other embodiments, when the dispenser actuation rate is 0.5 actuations per hour, less than 5% of the time the dispenser output will be outside the 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 0.5 actuations per hour, less than 1% of the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one embodiment, when the dispenser actuation rate is 0.5 actuations per hour, less than 0.5% of the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 0.5 actuations per hour, substantially none of the dispenser output will be located outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle.

In some embodiments, when the dispenser actuation rate is 3 actuations per hour, less than 40% of the time, the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In other embodiments, when the dispenser actuation rate is 3 actuations per hour, less than 30% of the time, the dispenser output will be outside the 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 3 actuations per hour, less than 20% of the time, the dispenser output will be outside the 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one embodiment, when the dispenser actuation rate is 3 actuations per hour, less than 15% of the time the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 3 actuations per hour, substantially none of the dispenser output will lie outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle.

In some embodiments, when the dispenser actuation rate is 3 actuations per hour, less than 10% of the time, the dispenser output will be outside the 2.5 square inch area approximately 3 inches directly below the dispenser nozzle. In other embodiments, when the dispenser actuation rate is 3 actuations per hour, less than 5% of the time the dispenser output will be outside the 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 3 actuations per hour, less than 1% of the dispenser output will be outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle. In one embodiment, when the dispenser actuation rate is 3 actuations per hour, less than 0.5% of the dispenser output will be located outside of a 2.5 square inch area approximately 3 inches directly below the dispenser nozzle. In one or more embodiments, when the dispenser actuation rate is 3 actuations per hour, substantially none of the dispenser output will lie outside of a 2.5 inch square area approximately 3 inches directly below the dispenser nozzle.

In one or more embodiments, the effectiveness of the anti-blocking additive can be expressed as a percentage reduction in misdirection frequency. That is to say, the hydroalcoholic gel composition containing the anti-blocking additive can be compared with the control sample without the anti-blocking additive. The frequency of misdirection can be determined as above, and the percent reduction in misdirection frequency can be calculated for the composition containing the anti-blocking additive compared to the control. More generally, the percent reduction in misdirection frequency can be calculated for any motion rate and any output target area relative to a control composition without any anti-blocking additive and tested under the same conditions. In one or more embodiments, the percent reduction in misdirection frequency is at least about 50%. In other embodiments, the percent reduction in misdirection frequency is at least about 60%, in other embodiments at least about 70%, in still other embodiments at least about 80%. In one or more embodiments, the percent reduction in misdirection frequency is at least about 90%, in other embodiments at least about 95%, and in still other embodiments at least about 97%.

In order to verify the practice of the present invention, the following examples were prepared and tested. However, the examples should not be viewed as limiting the scope of the invention. The claims are used to define the invention.

Example

Example 1-7

并行式分配器(side-by-sidedispenser)来分配凝胶。分配器符合ADA，特征在于单手推式操作。对于所用样品动作速率保持常数。输出靶位于喷嘴尖端下方大约3英寸处，限定为2.5平方英寸。对每种组合物，提供了基于动作总数的方向错误百分比。Hydroalcoholic gel formulations were prepared by mixing the ingredients in the amounts shown in Tables 3-6 below. By using GOJO NXT with 1000ml refill volume and DP1 pump

Parallel dispenser (side-by-side dispenser) to distribute the gel. Dispenser is ADA compliant and features one-hand push operation. The motion rate was kept constant for the samples used. The output target is located approximately 3 inches below the nozzle tip and is defined as 2.5 inches square. For each composition, the percentage of misdirection based on the total number of movements is provided.

Testing was performed over 15 days, with each sample tested in multiple dispensers. Accordingly, the percentage data in the table below is an average of up to about 900 actuations observed for each formulation. In the case of a high frequency of misdirection, a deposit of coagulated gel was observed on the dispenser nozzle surface.

table 3

weight% Example 1 Example 2 Example 3 water Appropriate amount Appropriate amount Appropriate amount Acrylate/C 10-30 Alkyl Acrylate 0.3 0.3 0.3 Alcohol SDA 3C 74 74 74 Glycerin 0.25 0.25 0.25

Aminomethylpropanol (95%) .098 .098 0.098 Diisopropyl sebacate 0.25 ---- 0.25 PEG/PPG-20/6 Simethicone (65%) 0.10 ---- ---- Spices ---- ---- 0.13 Tocopheryl Acetate ---- ---- 0.001 Isopropyl myristate 0.25 0.001 0.001 % wrong direction 2.0 52.0 7.7

Table 4

weight% Example 4 Example 5 water Appropriate amount Appropriate amount Carbomer 0.25 0.25 Alcohol SDA 3C 65 65 Glycerin 0.25 0.25 Aminomethylpropanol 0.098 0.098 Diisopropyl sebacate ---- 0.5 Isopropyl myristate 0.5 ---- % wrong direction 7.1 0

table 5

weight% Example 6 water Appropriate amount Carbomer 0.23 Alcohol SDA 3C 64.5

Glycerin 0.25 Aminomethylpropanol 0.098 Diisopropyl sebacate ---- Isopropyl myristate 0.001 Spices 0.13 Tocopheryl Acetate 0.001 % wrong direction 35.0

Table 6

weight% Example 7 water Appropriate amount Carbomer 0.23 Alcohol SDA 3C 64.5 Glycerin 0.25 Aminomethyl propanol 0.098

Diisopropyl sebacate 0.25 Isopropyl myristate ---- Spices 0.13 Tocopheryl Acetate 0.0001 % wrong direction 0.44

Example 8-16

Examples 8-16 are hydroalcoholic gel formulations containing approximately 74 wt% ethanol SDA3C. Each of them also contained the following ingredients in the same amount: Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glycerin, Aminomethylpropanol, and Water. Examples 8-16 differ in the amount and type of anti-blocking additives included in the formulations. They are summarized in Table 7 below. Example 9 differs from Example 8 only in that Example 9 includes 0.13 wt% fragrance. Examples 8-16 were assigned and tested for misdirection frequencies as described above for Examples 1-7. Example 8 was designed as a control sample, and the misdirection frequencies of Examples 9-16 were normalized based on Example 8. Table 7 summarizes the percent reduction in misdirection frequency, which can also be referred to as the percent reduction in misdirection output for Examples 9-16 relative to Example 8.

Table 7

Example number Anti-blocking additive (wt.%) (%) Direction error output drops 8 none N/A 9 none 5.66 10 0.25% di-PPG-3-hexadecyl polyoxyethylene (4) ether adipate 97.13 11 0.5% di-PPG-3-hexadecyl polyoxyethylene (4) ether adipate 98.19 12 0.5% di-PPG-2-tetradecyl polyoxyethylene (10) ether adipate 97.94 13 0.5% Di-PPG-3 myristyl ether adipate 98.45 14 0.5% PPG-2 Myristyl Ether Propionate 99.37

15 0.5% triacetylglycerides 55.75 16 1.0% Triacetylglycerides 57.95

Various changes and modifications without departing from the spirit and scope of the invention will become apparent to those skilled in the art. The present invention is not intended to be limited to the exemplary embodiments presented herein.

Claims (40)

1. A method of reducing the formation of coagulated gel precipitates, said method comprising the steps of: A _C1-4 alcohol, an effective amount of a polyacrylate thickener, and an anti-blocking additive are combined to form a dispensable gel composition, wherein the anti-blocking additive comprises an ester having 2-6 ester groups or A polymeric ester comprising at least one ester group, and wherein said composition comprises at least about 40% by weight of said alcohol and less than about 1% by weight of fatty alcohol, petrolatum, mineral oil, or mixtures thereof, all based on said dispensable The total weight of the gel composition; and, Storing the dispensable gel in a periodically acting pump dispenser wherein the formation of coagulated gel deposits is reduced compared to a dispensable gel not including the anti-clogging additive. 2. The method according to claim 1, wherein the alcohol comprises methanol, ethanol, propanol, isopropanol, butanol, isobutanol, t-butanol or mixtures thereof. 3. The method according to claim 1, wherein said ester anti-blocking additive comprises one or more of the following: C1-C30 alcohol ester of C1-C30 carboxylic acid, ethylene glycol monoester of C1-C30 carboxylic acid, C1 -Ethylene glycol diesters of C30 carboxylic acids, propylene glycol monoesters of C1-C30 carboxylic acids, propylene glycol diesters of C1-C30 carboxylic acids, C1-C30 carboxylic acid monoesters and polyesters of polypropylene glycol, C1-C30 carboxylic acids Polyesters of monoesters and polypropylene glycols, polyesters of C1-C30 carboxylic acid monoesters and C4-C20 alkyl ethers, polyesters of C1-C30 carboxylic acid monoesters and di-C8-C30 alkyl ethers, and mixtures thereof . 4. The method according to claim 1, wherein said ester anti-blocking additive comprises one or more of the following: C1-C22 alcohol ester of C1-C22 carboxylic acid, C11-C22 alcohol ester of C3-C10 carboxylic acid, C1 -Ethylene glycol monoester of C22 carboxylic acid, ethylene glycol diester of C1-C22 carboxylic acid, propylene glycol monoester of C1-C22 carboxylic acid, propylene glycol diester of C1-C22 carboxylic acid, C1-C22 carboxylic acid monoester Polyester with polypropylene glycol, C1-C22 carboxylic acid monoester and polypropylene glycol polyester, C1-C22 carboxylic acid monoester and C4-C22 alkyl ether polyester, C1-C22 carboxylic acid monoester and di-C8 - Polyesters of C22 alkyl ethers, and mixtures thereof. 5. The method of claim 1, wherein the ester anti-blocking additive is formed from an acid having from about 4 to about 28 carbon atoms and an alcohol having from about 2 to about 22 carbon atoms. 6. The method of claim 1, wherein the ester anti-blocking additive comprises a polymer chain comprising up to about 12 PEG units, PPG units, or combinations thereof. 7. The method according to claim 1, wherein said ester anti-blocking additive is represented by the following formula:

wherein R is a linear or branched alkyl group having ¹ to about 28 carbon atoms; wherein each ^R can be the same or different, including polyethers having 1 to about 12 PEG or PPG groups or combinations thereof chain; wherein each R ³ may be the same or different, including a branched or straight chain alkyl or alkylene group having 1 to about 30 carbon atoms, and wherein each R ³ is attached to R ² via an ether bond. 8. The method according to claim 1, wherein said ester anti-blocking additive is represented by the following formula:

wherein ^R includes straight or branched chain alkyl or alkylene groups having 1 to about 22 carbon atoms, wherein n is an integer of 1 to about 20, wherein x is 0 or an integer of up to about 12, and wherein y is 0 or an integer up to about 12. 9. The method according to claim 1, wherein said ester anti-blocking additive is represented by the following formula:

wherein R ¹ is a linear or branched alkyl group having 1 to about 28 carbon atoms; wherein R ² comprises a polyether chain having 1 to about 12 PEG or PPG groups or combinations thereof, wherein R ³ comprises a polyether chain having 1-A branched or linear alkyl or alkylene group of about 30 carbon atoms, and wherein the ^R3 group is connected to ^R2 via an ether bond. 10. The method according to claim 1, wherein said ester anti-blocking additive comprises acetyl tributyl citrate, acetyl triethyl citrate, acetyl triethylhexyl citrate, acetyl trihexyl lemon Butyl benzyl phthalate, Butyl phthaloyl butyl glycolate, Butyryl trihexyl citrate, Dibutyl adipate, Dibutyl octyl malate, Dibutyl oxalate, dibutyl phthalate, dibutyl sebacate, dioctyl adipate, dicapryl/octyl sebacate, diethylene glycol dibenzoate Esters, diethylene glycol diethylhexanoate/diisonononate, diethylene glycol diisonononate, diethylene glycol abietate, diethylhexyl adipate, diethylhexyl Phthalate, Diethylhexyl sebacate, Diethylhexyl succinate, Diethylhexyl terephthalate, Diethyl oxalate, Diethyl phthalate ester, diethyl sebacate, diethyl succinate, diisoamyl malate, diisobutyl adipate, diisobutyl maleate, diisobutyl oxalate , diisohexadecyl adipate, diisohexadecyl dodecanedioate, diisodecyl adipate, diisononyl adipate, diisohexadecyl adipate Diacid ester, diisooctyl maleate, diisooctyl sebacate, diisopropyl adipate, diisopropyl oxalate, diisopropyl sebacate, diisopropyl adipate Propyl dimer dilinoleate, diisostearyl adipate, diisostearyl fumarate, diisostearyl glutarate, diisostearyl malate, Diisostearyl sebacate, Dimethyl adipate, Dimethyl oxalate, Dimethyl phthalate, Dioctyl dodecyl adipate, Dioctyl Dodecyl dimer dilinoleate, Dioctyl dodecyl dodecanedioate, Dioctyl dodecyl fluoroheptyl citrate, Dioctyl dodecyl IPDI, Dioctyldodecyl lauroyl glutamate, Dioctyl dodecyl malate, Dioctyl dodecyl sebacate, Dioctyl dodecyl stearoyl glutamate Ester, dipentaerythritol-based hexa-c5-9 ester, dipentaerythritol-based hexa-c5-10 ester, dipropyl oxalate, pentaerythritol-based tetra-c5-9 ester, pentaerythritol-based tetra-c5-10 ester, tributyl Citrate, Tricapryl/Octyl Trimellitate, Triethyl Citrate, Triethylene Glycol Dibenzoate, Triethylene Glycol Rosinate, Triethylhexyl Citrate, Tris Ethylhexyl Trimellitate, Trimethylpentyl Dibenzoate, Trimethylpentyl Diisobutyrate, Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Pentahydroxy Stearate, Polyglyceryl-10 Pentaisostearate, Polyglyceryl-10 Pentalaurate, Polyglyceryl-10 Pentalinoleate, Polyglyceryl-5 Pentamyristate, Poly Glyceryl-4-pentoleate, Polyglyceryl-6 pentaoleate, Polyglyceryl-10 pentaoleate, Polyglyceryl-3 penta-ricinoleate, Polyglyceryl-6 penta-ricinoleic acid Esters, Polyglyceryl-10 Pentaricinoleate, Polyglyceryl-4 Pentastearate, Polyglyceryl-6 Pentastearate, Polyglyceryl-10 Pentastearate Ester, polyoxyethylene (20) sorbitan pentaisostearate, polyoxyethylene sorbitan (30) pentaisostearate, polyoxyethylene sorbitan (40) pentaisostearate, Sorbitan polyoxyethylene (50) ether pentaisostearate, sorbitan polyoxyethylene (40) ether pentaoleate, sucrose pentaerucate, triacetylglyceride, di-PPG-3-hexadecane Polyoxyethylene (4) ether adipate, di-PPG-2-tetradecyl polyoxyethylene (10) ether adipate, di-PPG-3-myristyl ether adipate, PPG-2-myristyl ether propionate, or a mixture thereof. 11. The method of claim 1, wherein the ester anti-blocking additive comprises di-PPG-3-hexadecyl polyoxyethylene (4) ether adipate, di-PPG-2-tetradecyl polyoxyethylene Ethylene (10) ether adipate, di-PPG-3-myristyl ether adipate, PPG-2-myristyl ether propionate, or a mixture thereof. 12. The method according to claim 1, wherein said polyacrylate thickener is selected from the group consisting of carbomers, acrylates/C10-30 alkyl acrylate crosspolymers, acrylic acid and alkyl (C5- C10) Copolymers of acrylates, copolymers of acrylic acid and maleic anhydride, and mixtures thereof. 13. The method of claim 1, wherein the composition comprises from about 0.005 wt% to about 4 wt% of the ester anti-blocking additive, based on the total weight of the composition. 14. A method of reducing the frequency of misdirection output from a gel dispenser, said method comprising the steps of: A _C1-4 alcohol, an effective amount of a polyacrylate thickener, and an anti-blocking additive are combined to form a dispensable gel composition, wherein the anti-blocking additive comprises an ester having 2-6 ester groups or A polymeric ester comprising at least one ester group, and wherein said composition comprises at least about 40% by weight of said alcohol and less than about 1% by weight of fatty alcohol, petrolatum, mineral oil, or mixtures thereof, all based on said dispensable The total weight of the gel composition; and The dispensable gel is stored in a pump dispenser including an outlet and cyclically acting, wherein the frequency of misdirected outputs is reduced compared to a dispensable gel not including the anti-clogging additive. 15. The method of claim 14, wherein when the dispenser actuation rate is 0.1 actuations per hour, the dispenser output is located less than 50% of the time outside of a 2.5 inch square area approximately 3 inches directly below the dispenser outlet. 16. The method of claim 14, wherein the frequency of misdirection output from the dispenser is reduced by at least about 50% when compared to a control gel tested under the same conditions. 17. The method of claim 14, wherein the frequency of misdirection output from the dispenser is reduced by at least about 70% when compared to a control gel tested under the same conditions. 18. The method of claim 14, wherein the frequency of misdirection output from the dispenser is reduced by at least about 90% when compared to a control gel tested under the same conditions. 19. The method of claim 14, wherein the ester anti-blocking additive comprises a polymer chain comprising up to about 12 PEG units, PPG units, or combinations thereof. 20. The method according to claim 14, wherein said ester anti-blocking additive is represented by the following formula:

wherein R is a linear or branched alkyl group having ¹ to about 28 carbon atoms; wherein each ^R can be the same or different, including polyethers having 1 to about 12 PEG or PPG groups or combinations thereof chain; wherein each R ³ may be the same or different, including straight or branched chain alkyl or alkylene groups having 1 to about 30 carbon atoms, and wherein each R ³ group is attached to R ² via an ether bond superior. 21. The method according to claim 14, wherein said ester anti-blocking additive is represented by the following formula:

wherein ^R comprises a linear or branched alkyl or alkylene group having 1 to about 22 carbon atoms, wherein n is an integer of 1 to about 20, wherein x is 0 or an integer of up to about 12, and wherein y is 0 or an integer up to about 12. 22. The method according to claim 14, wherein said ester anti-blocking additive is represented by the following formula:

wherein R ¹ is a linear or branched alkyl group having 1 to about 28 carbon atoms; wherein R ² comprises a polyether chain having 1 to about 12 PEG or PPG groups or combinations thereof, wherein R ³ comprises a polyether chain having 1-A branched or linear alkyl or alkylene group of about 30 carbon atoms, and wherein ^R3 is connected to ^R2 via an ether bond. 23. The method according to claim 14, wherein said ester anti-blocking additive comprises acetyl tributyl citrate, acetyl triethyl citrate, acetyl triethylhexyl citrate, acetyl trihexyl lemon Butyl benzyl phthalate, Butyl phthaloyl butyl glycolate, Butyryl trihexyl citrate, Dibutyl adipate, Dibutyl octyl malate, Dibutyl oxalate, dibutyl phthalate, dibutyl sebacate, dioctyl adipate, dicapryl/octyl sebacate, diethylene glycol dibenzoate Esters, diethylene glycol diethylhexanoate/diisonononate, diethylene glycol diisonononate, diethylene glycol abietate, diethylhexyl adipate, diethylhexyl Phthalate, Diethylhexyl sebacate, Diethylhexyl succinate, Diethylhexyl terephthalate, Diethyl oxalate, Diethyl phthalate ester, diethyl sebacate, diethyl succinate, diisoamyl malate, diisobutyl adipate, diisobutyl maleate, diisobutyl oxalate , diisohexadecyl adipate, diisohexadecyl dodecanedioate, diisodecyl adipate, diisononyl adipate, diisohexadecyl adipate Diacid ester, diisooctyl maleate, diisooctyl sebacate, diisopropyl adipate, diisopropyl oxalate, diisopropyl sebacate, diisopropyl adipate Propyl dimer dilinoleate, diisostearyl adipate, diisostearyl fumarate, diisostearyl glutarate, diisostearyl malate, Diisostearyl sebacate, Dimethyl adipate, Dimethyl oxalate, Dimethyl phthalate, Dioctyl dodecyl adipate, Dioctyl Dodecyl dimer dilinoleate, Dioctyl dodecyl dodecanedioate, Dioctyl dodecyl fluoroheptyl citrate, Dioctyl dodecyl IPDI, Dioctyldodecyl lauroyl glutamate, Dioctyl dodecyl malate, Dioctyl dodecyl sebacate, Dioctyl dodecyl stearoyl glutamate Ester, dipentaerythritol-based hexa-c5-9 ester, dipentaerythritol-based hexa-c5-10 ester, dipropyl oxalate, pentaerythritol-based tetra-c5-9 ester, pentaerythritol-based tetra-c5-10 ester, tributyl Citrate, Tricapryl/Octyl Trimellitate, Triethyl Citrate, Triethylene Glycol Dibenzoate, Triethylene Glycol Rosinate, Triethylhexyl Citrate, Tris Ethylhexyl Trimellitate, Trimethylpentyl Dibenzoate, Trimethylpentyl Diisobutyrate, Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Pentahydroxy Stearate, Polyglyceryl-10 Pentaisostearate, Polyglyceryl-10 Pentalaurate, Polyglyceryl-10 Pentalinoleate, Polyglyceryl-5 Pentamyristate, Poly Glyceryl-4-pentoleate, Polyglyceryl-6 pentaoleate, Polyglyceryl-10 pentaoleate, Polyglyceryl-3 penta-ricinoleate, Polyglyceryl-6 penta-ricinoleic acid Esters, Polyglyceryl-10 Penta-ricinoleate, Polyglyceryl-4 Penta-Stearate, Polyglyceryl-6 Penta-Stearate, Polyglyceryl-10 Penta-Stearate Ester, polyoxyethylene (20) sorbitan pentaisostearate, polyoxyethylene sorbitan (30) pentaisostearate, polyoxyethylene sorbitan (40) pentaisostearate , Sorbitol polyoxyethylene (50) ether pentaisostearate, sorbitan polyoxyethylene (40) ether pentaoleate, sucrose pentaerucate, triacetylglyceride, di-PPG-3-hexadecyl Alkyl polyoxyethylene (4) ether adipate, Di-PPG-2-tetradecyl polyoxyethylene (10) ether adipate, Di-PPG-3-myristyl ether adipate , PPG-2-myristyl ether propionate, or a mixture thereof. 24. The method of claim 14, wherein the ester anti-blocking additive comprises di-PPG-3-hexadecyl polyoxyethylene (4) ether adipate, di-PPG-2-tetradecyl polyoxyethylene Ethylene (10) ether adipate, di-PPG-3-myristyl ether adipate, PPG-2-myristyl ether propionate, or a mixture thereof. 25. The method according to claim 14, wherein said polyacrylate thickener is selected from the group consisting of carbomer, acrylates/C10-30 alkyl acrylate crosspolymer, acrylic acid and alkyl (C5- C10) Copolymers of acrylates, copolymers of acrylic acid and maleic anhydride, and mixtures thereof. 26. The method of claim 14, wherein the composition comprises from about 0.005 wt% to about 4 wt% of the ester anti-blocking additive, based on the total weight of the composition. 27. A gel composition comprising: At least about 60% by weight of C _1-4 alcohols, based on the total weight of the gel composition; An effective amount of polyacrylate thickener; Ester anti-blocking additives comprising 2-6 ester groups, or polymeric esters comprising at least one ester group; and Less than about 1 weight percent fatty alcohol, petrolatum, mineral oil, or mixtures thereof, based on the total weight of the gel composition. 28. The composition according to claim 27, wherein the alcohol comprises methanol, ethanol, propanol, isopropanol, butanol, isobutanol, tert-butanol or mixtures thereof. 29. The composition according to claim 27, wherein said ester anti-blocking additive comprises one or more of the following: C1-C30 alcohol esters of C1-C30 carboxylic acids, ethylene glycol monoesters of C1-C30 carboxylic acids, Ethylene glycol diester of C1-C30 carboxylic acid, propylene glycol monoester of C1-C30 carboxylic acid, propylene glycol diester of C1-C30 carboxylic acid, C1-C30 carboxylic acid monoester and polyester of polypropylene glycol, C1-C30 carboxylic acid Polyester of acid monoester and polypropylene glycol, polyester of C1-C30 carboxylic acid monoester and C4-C20 alkyl ether, polyester of C1-C30 carboxylic acid monoester and di-C8-C30 alkyl ether, and mixture. 30. The composition according to claim 27, wherein said ester anti-blocking additive comprises one or more of the following: C1-C22 alcohol esters of C1-C22 carboxylic acids, C11-C22 alcohol esters of C3-C10 carboxylic acids, Ethylene glycol monoester of C1-C22 carboxylic acid, ethylene glycol diester of C1-C22 carboxylic acid, propylene glycol monoester of C1-C22 carboxylic acid, propylene glycol diester of C1-C22 carboxylic acid, C1-C22 carboxylic acid monoester Polyester and polypropylene glycol, C1-C22 carboxylic acid monoester and polypropylene glycol polyester, C1-C22 carboxylic acid monoester and C4-C22 alkyl ether polyester, C1-C22 carboxylic acid monoester and di- Polyesters of C8-C22 alkyl ethers, and mixtures thereof. 31. The composition according to claim 27, wherein said ester anti-blocking additive is formed from an acid having from about 8 to about 22 carbon atoms and an alcohol having from about 2 to about 22 carbon atoms. 32. The composition of claim 27, wherein the ester anti-blocking additive comprises a polymer chain comprising up to about 12 PEG units, PPG units, or combinations thereof. 33. The composition according to claim 27, wherein said ester anti-blocking additive is represented by the formula: wherein R is a linear or branched alkyl group having ¹ to about 28 carbon atoms; wherein each ^R can be the same or different, including polyethers having 1 to about 12 PEG or PPG groups or combinations thereof chain; wherein each R ³ may be the same or different, including a linear or branched alkyl or alkylene group having 1 to about 30 carbon atoms, and wherein each R ³ is connected to R ² via an ether bond. 34. The composition according to claim 27, wherein said ester anti-blocking additive is represented by the formula:

wherein ^R comprises a linear or branched alkyl or alkylene group having 1 to about 22 carbon atoms, wherein n is an integer of 1 to about 20, wherein x is 0 or an integer of up to about 12, and wherein y is 0 or an integer up to about 12. 35. The composition according to claim 27, wherein said ester anti-blocking additive is represented by the formula:

wherein R ¹ is a linear or branched alkyl group having 1 to about 28 carbon atoms; wherein R ² comprises a polyether chain having 1 to about 12 PEG or PPG groups or combinations thereof, wherein R ³ comprises a polyether chain having 1-A branched or linear alkyl or alkylene group of about 30 carbon atoms, and wherein the ^R3 group is connected to ^R2 via an ether bond. 36. The composition according to claim 27, wherein said ester anti-blocking additive comprises acetyl tributyl citrate, acetyl triethyl citrate, acetyl triethylhexyl citrate, acetyl trihexyl citrate, Citrate, Butylbenzylphthalate, Butylphthalylbutylglycolate, Butyryltrihexylcitrate, Dibutyladipate, Dibutyloctylmalate , Dibutyl oxalate, Dibutyl phthalate, Dibutyl sebacate, Dioctyl adipate, Dicapryl/octyl sebacate, Diethylene glycol dibenzoate diethylene glycol diethylhexanoate/diisonononate, diethylene glycol diisonononate, diethylene glycol abietate, diethylhexyl adipate, diethyl Hexyl phthalate, diethylhexyl sebacate, diethylhexyl succinate, diethylhexyl terephthalate, diethyl oxalate, diethyl phthalate diethyl sebacate, diethyl succinate, diisoamyl malate, diisobutyl adipate, diisobutyl maleate, diisobutyl oxalate Esters, diisohexadecyl adipate, diisohexadecyl dodecanedioate, diisodecyl adipate, diisononyl adipate, diisohexadecyl Adipate, diisooctyl maleate, diisooctyl sebacate, diisopropyl adipate, diisopropyl oxalate, diisopropyl sebacate, diisopropyl sebacate, Isopropyl dimer dilinoleate, diisostearyl adipate, diisostearyl fumarate, diisostearyl glutarate, diisostearyl malate , diisostearyl sebacate, dimethyl adipate, dimethyl oxalate, dimethyl phthalate, dioctyl dodecyl adipate, dioctyl Dioctyl dodecyl dimer dilinoleate, Dioctyl dodecyl dodecane dioate, Dioctyl dodecyl fluoroheptyl citrate, Dioctyl dodecyl IPDI , Dioctyldodecyl lauroyl glutamate, Dioctyl dodecyl malate, Dioctyl dodecyl sebacate, Dioctyl dodecyl stearoyl glutamine Dipentaerythritol-based hexa-c5-9 ester, dipentaerythritol-based hexa-c5-10 ester, dipropyl oxalate, pentaerythritol-based tetra-c5-9 ester, pentaerythritol-based tetra-c5-10 ester, tributyl Citrate, tricapryl/octyltrimelellitate, triethyl citrate, triethylene glycol dibenzoate, triethylene glycol abietate, triethylhexyl citrate, Triethylhexyl Trimellitate, Trimethylpentyl Dibenzoate, Trimethylpentyl Diisobutyrate, Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Penta Hydroxystearate, Polyglyceryl-10 Pentaisostearate, Polyglyceryl-10 Pentalaurate, Polyglyceryl-10 Pentalinoleate, Polyglyceryl-5 Pentamyristate, Polyglyceryl-4-pentoleate, Polyglyceryl-6 pentaoleate, Polyglyceryl-10 pentaoleate, Polyglyceryl-3 penta-ricinoleate, Polyglyceryl-6 penta-ricinoleate Ester, Polyglyceryl-10 Pentaricinoleate, Polyglyceryl-4 Pentastearate, Polyglyceryl-6 Pentastearate, Polyglyceryl-10 Pentastearate Fatty acid ester, sorbitol polyoxyethylene (20) ether pentaisostearate, sorbitan polyoxyethylene (30) ether pentaisostearate, sorbitan polyoxyethylene (40) ether pentaisostearate Ester, polyoxyethylene (50) sorbitan pentaisostearate, polyoxyethylene sorbitan (40) pentaoleate, sucrose pentaerucate, triacetylglyceride, di-PPG-3-deca Hexaalkyl polyoxyethylene (4) ether adipate, Di-PPG-2-tetradecyl polyoxyethylene (10) ether adipate, Di-PPG-3-myristyl ether adipate Esters, PPG-2-myristyl ether propionate, or mixtures thereof. 37. The composition of claim 27, wherein the ester anti-blocking additive comprises di-PPG-3-hexadecyl polyoxyethylene (4) ether adipate, di-PPG-2-tetradecyl polyoxyethylene (4) ether adipate, Oxyethylene(10) ether adipate, di-PPG-3-myristyl ether adipate, PPG-2-myristyl ether propionate, or a mixture thereof. 38. The composition according to claim 27, wherein said polyacrylate thickener is selected from the group consisting of carbomer, acrylates/C10-30 alkyl acrylate crosspolymer, acrylic acid and alkyl (C5 -C10) Copolymers of acrylates, copolymers of acrylic acid and maleic anhydride, and mixtures thereof. 39. The composition according to claim 27, wherein said composition comprises from about 0.005 wt% to about 4 wt% of an ester anti-blocking additive, based on the total weight of said composition. 40. The composition according to claim 27, wherein the viscosity of said composition is from about 1000 to about 65000 centipoise.