CN116343987A - A Personalized Adaptive Amblyopia Training System and Its Quantitative Analysis and Adjustment Method - Google Patents

Abstract

The invention discloses a personalized self-adaptive amblyopia training system and a quantitative analysis and adjustment method thereof.A control device performs quantitative analysis on visual function damage characteristics of an amblyopia patient through a amblyopia damage mechanism quantitative analysis model according to the recorded training performance of the amblyopia patient on visual patterns, so as to obtain the single-eye and double-eye visual function damage characteristics of the amblyopia patient, the weakening degree of an amblyopia input signal and the inter-eye inhibition degree of a non-amblyopia on the amblyopia input signal; according to the quantitative analysis result of the damage of the monocular and binocular vision functions and/or the damage mechanism of the amblyopia, the control device generates the individual training modes and doses which are most suitable for the damage degree and characteristics of the patient, the binocular training task and the combination thereof, and the like, and transmits the individual training modes and doses to the display device for the amblyopia patient to carry out vision training, the system automatically carries out self-adaptive adjustment on the training task in real time according to the task completion condition of the patient, and the process is repeated until the patient is healed, so that the pertinence is strong, and the training is efficient.

Description

A Personalized Adaptive Amblyopia Training System and Its Quantitative Analysis and Adjustment Method

technical field

The invention relates to the field of medical and health care equipment, in particular to a personalized adaptive amblyopia training system and its quantitative analysis and adjustment method, which can quantitatively evaluate the condition of amblyopia patients and perform personalized and adaptive amblyopia training.

Background technique

Amblyopia (Lazy eye) is a common ophthalmic disease caused by abnormal development of the visual nervous system during the growth and development of children. The incidence rate accounts for about 3-5% of the total population. The area responsible for processing visual information input to the amblyopic eye is underdeveloped, resulting in poor vision and amblyopia. The external manifestation of amblyopia is low vision in one or both eyes, and there is no organic damage to the eyes, but it cannot be corrected by glasses. A large number of studies have shown that, in addition to decreased vision, patients with amblyopia are usually accompanied by decreased contrast sensitivity, abnormal integration of binocular information, decreased motion perception, and decreased stereopsis. Amblyopia has the characteristics of "early detection, early treatment, late detection, difficult treatment". Clinically, there are about 30 million older children and adults with amblyopia in China who have no effective treatment measures, and 700,000 to 1 million new children with amblyopia are added every year.

Since amblyopia is often detected by parents in childhood, parents will actively seek medical assistance, and usually follow the doctor's instructions to actively carry out a long-term recovery course. As mentioned above, the traditional view is that amblyopia originates from the disuse of the visual nervous system to the amblyopic eye caused by abnormal visual input experiences during the development of the visual system (such as anisometropia, strabismus, cataract, etc.) Signal weakening), which is why amblyopia is also known as lazy eye. Therefore, covering the amblyopic eye (covering therapy) is the most commonly used method in the current treatment after removing the factors affecting visual input, that is, covering the relatively healthy eye and forcing the patient to use the amblyopic eye until the visual acuity of the amblyopic eye is improved to be equivalent to that of the relatively healthy eye. level. This therapy has been found to work only in some children with amblyopia (about 2/3), and it is basically ineffective for older children and adults with amblyopia, and it is not effective in restoring binocular functions such as stereopsis; the compliance of covering therapy is relatively low. Poor, on the one hand, some children with amblyopia refuse to cover for fear of being ridiculed when covering; Significantly affect the study and life of patients; the cycle of masking therapy is long, generally takes 1 to 3 years, which brings a heavy burden to patients and patients' families. Clinically, there is also a depressive therapy that applies atropine or a depressive film to the non-amlyopic eye to suppress the visual acuity of the non-amlyopic eye to a comparable level of the amblyopic eye. The effect and disadvantages are similar to those of the masking method. The rest of the treatment methods, such as instrument therapy, visual stimulation therapy or drug therapy, etc., the principle of treatment is to stimulate the amblyopic visual system from different aspects, promote the redevelopment of the amblyopic visual system, thereby improving the visual acuity of the amblyopic eye. But these methods all have defects in varying degrees, such as children need to cooperate to cover eyes during treatment, and the degree of cooperation is not high, and there is also the problem that some children refuse to cover because they are worried that they will be ridiculed by others.

In recent years, in order to improve the treatment effect, some comprehensive treatment devices for amblyopia have also been produced in this field. The common device is a mechanical device that uses the light source at the back of the device to illuminate the image or text board inserted into the device. Instructions are operated and implemented by the display glass plate of the device in accordance with the instructions and images or text boards, thereby enhancing vision. However, this kind of device has poor precision and is less suitable for patients, and many years of research have found that its effect is not good; there are also technical solutions in this field that try to use liquid crystal display screens to produce image changes. The principle of this treatment method is to exercise the visual system by allowing the eyeballs of the amblyopia to move within a larger range, and improve the blood circulation, metabolism, muscle movement and nerve reflex of the eyes. But this device can only train eyeball function, and use is complicated, needs to carry out complicated setting to liquid crystal display image for different amblyopia, can't be used by patients themselves. In response to the above problems, some new amblyopia training systems have also been tried in this field recently, such as the technical solutions disclosed in US 8066372, CN201410141132.6, etc. Compared with the traditional technical solutions, an evaluation module of binocular vision function has been added, and the treatment The visual function of both eyes is evaluated in advance, so as to generate a balance point between binocular vision training based on the evaluation result and present a binocular cooperative task for training. Although this technical solution overcomes some shortcomings of the traditional solution, it still does not take into account the potential differences in the mechanism of low vision caused by different amblyopia patients, and its entire treatment plan is based on the relative contrast sensitivity of the two eyes, the relative internal noise, the relative Response time, relative brightness sensitivity and other indicators to adjust the input signals of the two eyes, give the two eyes different and matching graphic stimuli, and perform visual perception training to improve vision. This treatment method lacks a comprehensive quantitative analysis of the degree of monocular damage and binocular damage of different amblyopia patients, and overemphasizes one of the damage degrees (that is, binocular function), and the resulting treatment plan will inevitably focus too much on one eye. Aspects of growth in visual function. Clinical experimental studies in recent years have shown that although binocular functional training alone can improve amblyopic stereopsis to a certain extent, the improvement effect on amblyopic eye vision is not good, and there is no correlation between the improvement of the two eyes, suggesting that monocular vision in amblyopic patients The mechanism of damage to binocular vision is not exactly the same, and individualized symptomatic treatment should be carried out during the treatment process.

In terms of treatment principles, the early training methods for amblyopia were aimed at strengthening the amblyopia eye (i.e. monocular strengthening), while the newly emerging training methods in the recent field focus on strengthening the function of the amblyopia eyes. These different programs are mostly intensive training for a single visual function or a simple combination of several types of training. The training methods ignore that different amblyopic patients may have different causes and mechanisms (anisometropia or strabismus), and different visual function impairments. and different degrees of damage; implementing the same training measures for all amblyopia patients without specific quantitative analysis of the degree and mechanism of amblyopia may significantly affect the training effect, and even lead to ineffective or harmful training.

Contents of the invention

Aiming at the defects of amblyopia training in the prior art, the present invention provides a personalized adaptive amblyopia training system and its quantitative analysis and adjustment method. Quantitatively analyze the weakening degree of its own signal input and the degree of abnormal inhibition of the non-amblyopic eye on the amblyopic eye, and then according to the quantitative evaluation results, provide the amblyopic patients with personalized monocular training, binocular training tasks and their combinations that are most suitable for the degree and characteristics of the patient's own damage Task training mode and dosage; during the training process, the system automatically and in real time adjusts the training task automatically and in real time according to the patient's task completion, and repeats the process until the binocular vision function is improved.

The present invention adopts following technical scheme:

On the one hand, the present invention provides a personalized adaptive amblyopia training system, the system includes a control device, a display device and an interaction device; the control device contains a visual training task database and amblyopia damage mechanism quantitative analysis model, the A variety of visual patterns are provided in the visual training task database, the control device is connected with the display device and the interactive device, and the interactive device is used to adjust the physical properties of the visual image observed by the amblyopic patient through the display device, And feed back to the control device;

According to the recorded performance of the amblyopia patients in training the visual pattern, the control device quantifies and analyzes the characteristics of the visual function impairment of the amblyopia patients through the quantitative analysis model of the amblyopia damage mechanism, and obtains the monocular and binocular visual function impairment characteristics of the amblyopia patients , the degree of weakening of the amblyopic eye input signal and the interocular inhibition degree of the non-amblyopic eye to the amblyopic eye input signal; according to the quantitative analysis results of monocular and binocular visual function damage and/or amblyopia damage mechanism, the control device is controlled by the visual training task database Extract the visual pattern from the image, generate a personalized visual training task for the amblyopic patient, and transmit it to the display device for the amblyopic patient to perform visual training.

Further, the control device is a device with program execution, data processing and storage functions, including but not limited to computers (PC, Mac), tablet computers (iPad, etc.), mobile phones or any other processors with programmable functions , memory.

Preferably, the display device is a display capable of realizing binocular separation and/or a device that assists in realizing binocular separation.

Further, the binocular vision patterns displayed by the display device have the same, similar or complementary visual patterns, and the interaction device can adjust the physical properties of the presented visual patterns to make them the same or different.

Preferably, said interaction means is a means by which user feedback on the visual training task can be given, which is one of a joystick, a device with a plurality of buttons, a mouse, a reaction box, a touch screen with a plurality of clickable options kind.

The visual training task is to stimulate the retinal receptor cells of the human eye and quantify the visual graphics of the measured physical properties, including sinusoidal gratings, square wave gratings, Gabor gratings, original or filtered numbers/Chinese characters/letters, original or filtered natural One or a combination of stimuli, dots, or visual noise patterns.

The system also includes a wired or wireless communication device, the communication device is connected to the control device, and the training result of the amblyopia patient and the result on the training participation evaluation task are returned to the amblyopia patient, children through the communication device. Parents of patients, professional doctors and sensory training experts, professional doctors and sensory training experts track and accurately evaluate the training results and the degree of participation of amblyopia patients during the training period in real time, and make personalized adjustments to the follow-up training programs for amblyopia patients.

The individualized vision training task includes a training mode and a training dose, and the training mode includes a monocular vision function training task, a combination task of monocular vision function training and binocular vision function training, a combination task of binocular vision function training and monocular vision function training, binocular There are four modes of visual function training tasks; the training dose is 3000-12000 trials/task, and the average distribution is carried out according to 5-20 training times.

The interaction device adjusts the physical properties of visual images observed by amblyopia patients, including stimulus contrast, brightness, phase, orientation, angle, orientation, size, color, shape, spatial frequency, temporal frequency, three-dimensional depth, motion speed, and motion direction. , motion direction consistency level, binocular parallax, presentation time, presentation location or one or several physical attributes.

On the other hand, the present invention also provides an adaptive amblyopia quantitative analysis and adjustment method, said method comprising the following steps:

Step 1, the control device extracts the visual pattern from the visual training task database to form a visual training task, and transmits it to the display device for amblyopia patients to train monocular function and/or binocular function;

Step 2, adjust the physical properties of the first visual pattern observed by the amblyopic eye and/or the physical properties of the second visual pattern observed by the non-amblyopic eye through the interactive device. For judging the physical dimension of the visual pattern, the control device records and stores the physical attribute values of the first visual pattern observed by the amblyopic eye and/or the second visual pattern observed by the non-amblyopic eye;

Step 3, the control device sends an instruction to the display device, so that the display device gradually eliminates the first visual pattern or the second visual pattern or simultaneously eliminates the first and second visual patterns, waits for the amblyopia patient to make a task judgment, the control device records and Store the correct rate of judgment or reaction time data;

Step 4, as required, the controllable device sends an instruction to the display device, so that the display device displays a third visual pattern whose physical properties are different from the first visual pattern and the second visual pattern to the amblyopic eye of the amblyopic patient, and the third visual pattern the spatial location on the retina is adjacent to the spatial location of the first visual pattern and the second visual pattern;

Step 5, according to needs, the amblyopic patient adjusts the physical properties of the third visual pattern observed by the amblyopic eye through the interactive device until its visual perception is the same as the integrated pattern of the first visual pattern and the second visual pattern, and the control device Recording and storing the physical attribute value of the third visual pattern observed by the amblyopic eye;

Step 6, according to needs, the control device sends an instruction to the display device, so that the display device fades away to eliminate the third visual pattern;

Step 7, as required, the control device sends an instruction to the display device, so that the display device displays a fourth visual pattern whose physical properties are different from the first visual pattern and the second visual pattern to the non-amlyopic eye of the amblyopic patient, so that the fourth visual pattern the spatial location on the retina is adjacent to the spatial location of the first visual pattern and the second visual pattern;

Step 8, according to needs, the amblyopic patient adjusts the physical properties of the fourth visual pattern observed by the non-amblyopic eye through the interactive device until its visual perception is the same as the integrated visual pattern of the first visual pattern and the second visual pattern, The control device records and stores the physical attribute value of the fourth visual pattern observed by the non-amblyopic eye;

Step 9, according to the physical attribute values of the first visual pattern, the second visual pattern, the third visual pattern, and the fourth visual pattern, or according to the reaction time or correct rate data described in steps 1-3, the control device uses the amblyopia damage mechanism The quantitative analysis model quantifies the characteristics of visual function impairment, and obtains the specific value of the weakening degree of the input signal of the amblyopic eye and the degree of interocular inhibition of the input signal of the amblyopic eye by the non-amblyopic eye, and the performance function of the amblyopic eye and the non-amblyopic eye on the monocular task. Difference data and binocular vision function data;

Step 10, based on the binocular intensity data obtained in step 9, the function difference data between the amblyopic eye and the non-amlyopic eye, and the binocular vision function data, the control device forms a personalized training task, and obtains the patterns and methods of monocular intensive training and binocular training for amblyopic patients. Dosage, according to the setting and needs, repeat all or part of the steps from step 1 to step 9 until the set threshold or training intensity is reached, and the training is stopped.

The calculation formula of weakening degree of amblyopia eye input signal and degree of interocular inhibition in said step 9 is as follows:

The degree of attenuation of the input signal of the amblyopic eye is AF=1-m4/m3;

The interocular inhibition degree IF=[m4/(m2×m3)] ^N of the input signal of the non-amblyopic eye to the amblyopic eye, where N≥1 is a real number;

Wherein, m2, m3, and m4 are the physical attribute values of the second visual pattern, the third visual pattern and the fourth visual pattern, respectively.

The calculation method of the functional difference between the amblyopic eye and the non-amblyopic eye in the step 9 is as follows:

Function difference between amblyopic eye and non-amblyopic eye: DIFF＝m2/m1;

Among them, m1 and m2 are the physical attribute values of the first visual pattern, the third visual pattern and the fourth visual pattern obtained under the same accuracy rate or reaction time level respectively when performing monocular function measurement.

The calculation method of the binocular vision function in the step 9 is as follows:

Binocular vision function BF=(m1+m2)/2;

Wherein, m1 and m2 are the physical attribute values of the first visual pattern and the second visual pattern at a specific correct rate or response time level respectively when binocular function is measured, generally m1=m2.

In the step 10, the weakening degree of the amblyopic eye input signal AF is used as the main criterion, and the functional difference DIFF between the amblyopic eye and the non-amlyopic eye and the binocular vision function BF are used as auxiliary criteria;

When the weakening degree of the input signal of the amblyopic eye is AF>10%, the monocular (amblyopic eye) visual function strengthening training is adopted, and the training dose is calculated according to 100*INT (90*AF+30), and INT is a rounding function, (such as AF=0.36 , the total dose is 6200), and training is carried out at 400-1200 trials/day;

If the weakening degree of the input signal of the amblyopic eye is AF≤10%, binocular vision function training is adopted, and the training dose is calculated according to min(12000, max(100*INT(IF*10), 100*INT(90*AF+30)), And train according to 400-1200 trials/day.

When the degree of damage to the amblyopic eye and the degree of interocular inhibition cannot be reasonably estimated due to age, cognitive level, comprehension ability, or cooperation, it can be judged based on the functional difference DIFF between the amblyopic eye and the non-amlyopic eye:

If DIFF<60%, use monocular (amblyopia) visual function strengthening training, the training dose is calculated according to 100*INT[120*(1-DIFF)], and the training is carried out according to 400-1000 trials/day;

If DIFF>=60%, use binocular vision function training, training dose according to max(3000,100*INT[120*(1-DIFF)]), and train according to 400-1000 trials/day.

The method also includes: step 11, during the training process of the amblyopia patients, the amblyopia patients can regularly or according to their own needs send back the training results to professional doctors and training experts through communication devices, and the doctors or training experts can track and evaluate the training results in real time, The real-time adjustment of the training task and the training dose is carried out and then transmitted to the control device through the communication device for training of amblyopia patients.

The method also includes: step 12, during the training process, the amblyopic patients can periodically or according to their own needs return the evaluation of the training participation degree of the amblyopic patients to professional doctors, training experts and parents through the communication device, and the doctors or training experts Track and evaluate patient training participation and completion, and make human contact when needed.

The method also includes: step 13, after the amblyopia patient completes a training task, he can repeat steps 1-9 to carry out quantitative analysis of the visual function of the amblyopia eye and the non-amblyopia eye, the functional characteristics of both eyes and the mechanism of amblyopia damage, and then carry out Step 10 judges the degree of difference in function between the amblyopic eye and the non-amblyopic eye, the functional characteristics of both eyes and the extent of damage, and determines whether to continue training and the mode and dose of training.

In the step 10, when the interocular function difference data is less than 20%, the difference between binocular vision function data and the normal control is less than 20%, the degree of damage to the amblyopic eye is less than 10%, and the interocular inhibition coefficient is less than 2, it may be considered to terminate the training; Otherwise, repeat steps 1-10 to continue training.

The technical solution of the present invention has the following advantages:

A. The present invention comprehensively considers the differences in interocular function of different amblyopic patients, the function of both eyes, the degree of weakening of the input signal of the patient's own amblyopic eye, and the degree of inhibition of the input signal of the amblyopic eye by the non-amblyopic eye, rather than just considering amblyopia Eye function and binocular function, the control device compares the monocular function difference characteristics and binocular function characteristics of amblyopia eyes and non-amblyopia eyes by training different monocular vision functions and binocular vision functions, or analyzes the damage mechanism characteristics of amblyopia patients through models, for each Tailor-made training program for amblyopia patients, with personalized characteristics, is more effective in improving amblyopia and binocular vision.

B. The present invention is based on the visual training task database and the quantitative analysis model of the amblyopia damage mechanism, and performs self-adaptive adjustment in the training, real-time adjustment of the training task, stimulation parameters, degree of difficulty and dose, etc., so that the amblyopia can be better trained, Effectively improve and restore visual function.

C. After each training in the present invention, the training system will update the personalized training program for the amblyopia patient's previous task completion. The whole process is repeated until the patient's vision recovers. The interactive adaptability is stronger, and it is more conducive to carrying out amblyopia training for children. .

D. the present invention can improve patient's visual acuity, contrast sensitivity and stereopsis in a relatively short period of time (can be as low as 4 days, every day 30 minutes of training), strengthens the proportion of amblyopia eye in binocular competition, for severe amblyopia patient , It can quickly improve the visual acuity of the amblyopic eye in the early stage, so as to adapt to the traditional masking therapy and be more effective.

E. Since the present invention uses specially designed filter letters, the use of filter letters improves measurement accuracy and compliance, and is applicable to a wider age group and education level, and has very high user-friendliness and compliance. Users only need to be able to This task and training can be completed by identifying the eye chart.

Description of drawings

In order to illustrate the specific implementation of the present invention more clearly, the accompanying drawings used in the specific implementation will be briefly introduced below. Obviously, the accompanying drawings in the following description are some implementations of the present invention, which are common to those skilled in the art. As far as the skilled person is concerned, other drawings can also be obtained based on these drawings on the premise of not paying creative work.

Fig. 1 is the structural block diagram of amblyopia training system of the present invention;

Fig. 2 is the workflow diagram of the amblyopia training system of the present invention;

Fig. 3 is provided by the present invention to carry out quantitative analysis and the method for producing training strategy to the visual function impairment characteristic of amblyopia patient;

Fig. 4 is a graphical representation of the training results of the 20-year-old patient with anisometropia provided by the scheme of the present invention;

Fig. 5 is the illustration of the training result of the binocular amblyopia patient of 6-year-old children provided by the scheme of the present invention;

Fig. 6-1, Fig. 6-2 and Fig. 6-3 are illustrations of the results of amblyopia training for eleven adults provided by the solution of the present invention.

Detailed ways

The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are part of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" etc. The indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, or in a specific orientation. construction and operation, therefore, should not be construed as limiting the invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and should not be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that unless otherwise specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. Connected, or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention in specific situations.

As shown in Fig. 1, the present invention provides an adaptive amblyopia training system, which includes a control device, a display device and an interaction device connected to each other. The control device contains a visual training task database and a quantitative analysis model of amblyopia damage mechanism. There are various visual patterns in the visual training task database for visual training and testing of amblyopic patients; the interactive device is used to adjust the visual images observed by amblyopic patients The physical properties of the amblyopia patients are fed back to the control device; the control device records and stores the performance of the amblyopia patients during the training process, and quantitatively analyzes the visual function impairment characteristics of the amblyopia patients through the quantitative analysis model of the amblyopia damage mechanism, and obtains the monocular and binocular vision of the amblyopia patients Functional impairment characteristics, weakening degree of amblyopic eye input signal and interocular inhibition degree of non-amlyopic eye input signal to amblyopic eye; according to the quantitative analysis results of monocular and binocular visual function impairment and/or amblyopia impairment mechanism, the control device is controlled by the visual training task The visual pattern is extracted from the database, and a personalized visual training task for the amblyopic patient is generated, and transmitted to the display device for the amblyopic patient to perform visual training. The above process continues to circulate until the vision of amblyopia patients is improved to an appropriate range, and a vision training strategy based on the patient's own situation is realized in real time and adaptively adjusted. The vision adjustment is more targeted and more efficient.

The control device here is a device with program execution, data processing and storage functions, including but not limited to computers (PC, Mac), tablet computers (iPad, etc.), mobile phones or any other processors with programmable functions, memory, etc. processing unit.

Wherein, the display device is a display with a display function, which can display different visual patterns for the eyes of a person. Since it is necessary to output different images for the left and right eyes, a display device with a binocular display function is usually used. For example, the The polarized display is matched with the corresponding polarized 3D glasses, and the lenses receive two display signals respectively; it can also be a shutter type 3D display, and the left and right two sets of image frames sent by the display are respectively received by the 3D glasses; of course, it can also be a naked-eye 3D display Or a 3D projection device. In a word, any display device that can realize human eyes receiving two different images on the left and right can be used as the display device of the present invention. Preferably, in order to facilitate head-mounted use, the display device adopted in the present invention is a head-mounted display (HMD), and a large number of such products are on the market, such as the HMZ-T (1, 2, 3) series of Sony Corporation products, Oculus Rift head-mounted 3D display, etc.

In addition, the interactive device provided by the present invention can be a device for the user to provide feedback on the visual pattern of the visual task, such as a joystick, a device with multiple buttons, or a touch screen with multiple clickable options, etc.

In order to better realize the participation of remote experts, a wired or wireless communication device is also provided in the system. The communication device is connected to the control device, and the training results of the amblyopic patients and the results of the training participation evaluation task are sent back through the communication device. Amblyopia patients, parents of child patients, professional doctors and perception training experts, through real-time tracking and accurate evaluation of training results, and personalized adjustments to follow-up training programs for amblyopia patients, in order to better adjust vision.

The visual pattern used to realize the visual task in the present invention can be realized in many ways, including but not limited to sinusoidal grating, square wave grating, Gabor grating, original or filtered letters, original or filtered natural stimulation and other graphic methods. In a nutshell, as long as it is a graphic with physical properties that can stimulate retinal receptor cells in the human eye and be quantified, the physical properties can be contrast, brightness, phase, orientation, angle, orientation, size, color, shape, and spatial frequency. , time frequency, stereo depth, motion speed, motion direction, consistency level of motion direction, binocular disparity, presentation time, presentation position, etc., when training a specific visual task for a patient, usually Use a visual pattern of changes in physical properties.

The present invention comprehensively considers the functional difference between the amblyopic eye and the non-amblyopic eye, the functional characteristics of binocular vision, the weakening degree of the input signal of the amblyopic eye of different amblyopic patients, and the degree of inhibition of the input signal of the amblyopic eye by the non-amblyopic eye, rather than only considering the amblyopic eye The degree of weakening of the input signal of the eye or only considering the amblyopia binocular imbalance, according to the quantitative analysis model of the amblyopia damage mechanism, adaptive adjustment is made during the training, and the training tasks, difficulty level and dose are adjusted in real time, so as to better treat amblyopia. Train, quickly improve and restore visual function.

The training system of the present invention can quantify and distinguish the degree of weakening of the input signal of the amblyopic eye of the amblyopic patient and the degree of suppression of the input signal of the amblyopic eye by the non-amblyopic eye, and based on the results of the quantitative analysis, it can generate monocular strengthening training and binocular function strengthening for the amblyopic patient itself The mode and dose of training meet the needs of different types of amblyopia, so as to restore visual function more effectively and comprehensively.

The personalized visual training task program generated by this system includes monocular visual function training tasks (such as contrast detection training, contrast discrimination training, etc.) Training, noise exclusion, motion detection, motion direction discrimination, motion information integration, biological information, estimation, etc.); the main purpose is to enhance the coordination and consistency of amblyopic eyes and non-amblyopic eyes and improve binocular vision functions (such as spatial complementarity , time synchronization, stereopsis, binocular integration and competition, depth perception, etc.) binocular vision function training tasks (such as binocular coordination, binocular integration, binocular competition, interocular masking and stereopsis judgment, etc.); or monocular and binocular vision functions The core of the combination of training tasks is that the selection of different tasks, the sequence of training and the dose of training vary with the difference between the amblyopic eye and the non-amlyopic eye, the functional characteristics of both eyes, or the damage mechanism of the amblyopic patient.

The task combination selection and sequence in the personalized vision training task plan include monocular vision function training, monocular vision function training plus binocular vision function training, binocular vision function training plus monocular vision function training, binocular vision function training and other four different modes , the training dose is generally 3000-12000 trials/tasks, and it is evenly distributed according to 5-20 training times. The core lies in the degree of difference between amblyopic eyes and non-amblyopic eyes, binocular function or amblyopic eye signal attenuation in the damage mechanism of amblyopic patients Factors such as the relative ratio of interocular abnormal inhibition and monocular/binocular task priority training or not and the training dose are correlated. The visual training process in this system has the characteristics of self-adaptation. The system will adjust the physical parameters of the stimulation in real time according to the completion of each trial of the amblyopia patients, so that the performance of the patients in related tasks can be maintained at a relatively stable level; Physical parameters include but are not limited to stimulus contrast, brightness, orientation, orientation, size, movement speed, movement direction, consistency level of movement direction, binocular parallax, presentation time, presentation location, etc.

Fig. 2 has shown the workflow of the amblyopia training system of the present invention, and the control device sends visual pattern to the display device to evaluate the visual function of the amblyopia patient, and the amblyopia patient utilizes the interactive device to make a judgment according to the observation of the visual pattern by both eyes, and the interactive device sends the visual pattern to the control The device feeds back the performance of the amblyopia patient to complete the test task, and the control device calculates the degree of weakening of the amblyopia eye and the degree of inhibition of the non-amblyopia eye according to the feedback, so as to produce training tasks corresponding to its amblyopia pathogenesis for the amblyopia patient (including but not limited to monocular training, One or more tasks of binocular training) mode and dose, the visual pattern of this monocular strengthening training task after adjustment, binocular training task is displayed on the display device by the control device, and amblyopia patients are retrained, readjusted repeated training And the adjustment process until the eyes of amblyopia patients are adjusted to the appropriate range.

The present invention also provides a quantitative analysis and adjustment method for visual function impairment characteristics of amblyopia patients, as shown in Figure 3, which includes the following steps:

[S1] The control device extracts the visual pattern from the visual training task database to form a visual training task, and transmits it to the display device for amblyopia patients to train monocular function and/or binocular function; the display device provides amblyopia and non-amblyopia The first visual pattern and the second visual pattern are respectively displayed, wherein the first visual pattern and the second visual pattern have substantially the same pattern or complementary images, and the physical properties of the two displayed patterns are different. When training binocular function, the display device shows the first vision pattern and the second vision pattern respectively to the amblyopia eye and the non-amblyopia eye of the amblyopia patient. There are differences in the physical properties of the amblyopic patients; for example, when testing monocular function, the display device only presents the first visual pattern to the amblyopic eye of the amblyopic patient, or only presents the second visual pattern to the non-amblyopic eye of the amblyopic patient.

[S2] Use the interactive device to adjust the physical properties of the first visual pattern observed by the amblyopic eye and/or the physical properties of the second visual pattern observed by the non-amblyopic eye, and the amblyopic patients correspond to each other through the amblyopic eye and/or the non-amblyopic eye For judging the physical dimension of the visual pattern, the control device records and stores the physical attribute values of the first visual pattern observed by the amblyopic eye and/or the second visual pattern observed by the non-amblyopic eye.

When training binocular function, according to different functions, amblyopia patients can adjust the physical properties of the second visual pattern observed by the non-amblyopic eye through the interactive device until the balance point of the eyes is reached, and the control device records and stores what the non-amblyopic eye observes at this time The physical attribute value of the second visual pattern; amblyopia patients can also observe the first visual pattern and the second visual pattern with both eyes, and carry out the judgment of the physical dimension related to binocular vision (such as parallax, matching, complementarity, etc.), and the control device records and Store the physical parameters at this time; when testing the monocular function, according to the needs of the task, the amblyopic patient judges the corresponding physical dimension (such as contrast, stimulus, size, speed, direction, etc.) The control device records and stores the physical attribute values of the first visual pattern observed by the amblyopic eye or the second visual pattern observed by the non-amblyopic eye at this time.

[S3] The control device sends an instruction to the display device, so that the display device gradually eliminates the first visual pattern or the second visual pattern or simultaneously eliminates the first and second visual patterns, and waits for the amblyopic patient to make a task judgment, and the control device records and Store the correct rate of judgment or reaction time data;

[S4] The control device sends an instruction to the display device, so that the display device displays a third visual pattern whose physical properties are different from the first visual pattern and the second visual pattern to the amblyopic eye of the amblyopic patient, and the third visual pattern is on the retina The spatial location is located near the spatial location of the first visual pattern and the second visual pattern on the retina.

[S5] The amblyopic patient adjusts the physical properties of the third visual pattern observed by the amblyopic eye through the interactive device until its visual perception is the same as the integrated pattern of the first visual pattern and the second visual pattern, and the control device records and stores The physical attribute value of the third visual pattern observed by the amblyopic eye;

[S6] The control device sends an instruction to the display device, so that the display device fades away to eliminate the third visual pattern.

[S7] The control device sends an instruction to the display device, so that the display device displays a fourth visual pattern whose physical properties are different from the first visual pattern and the second visual pattern to the non-amblyopic eye of the amblyopic patient, so that the fourth visual pattern is on the retina The spatial location of is located near the spatial location of the first visual pattern and the second visual pattern on the retina.

[S8] The amblyopic patient adjusts the physical properties of the fourth visual pattern observed by the non-amblyopic eye through the interactive device until its visual perception is the same as the integrated visual pattern of the first visual pattern and the second visual pattern, and the control device records And storing the physical attribute value of the fourth visual pattern observed by the non-amblyopic eye;

[S9] According to the physical attribute values of the first visual pattern, the second visual pattern, the third visual pattern, and the fourth visual pattern, or according to the reaction time or accuracy data collected from steps [S1] to [S3], The control device quantitatively analyzes the visual function impairment characteristics of amblyopia patients through the quantitative analysis model of amblyopia damage mechanism, and obtains the specific value of the weakening degree of the input signal of the amblyopia eye and the degree of inhibition of the input signal of the amblyopia eye by the non-amlyopia eye. Differences in the performance of monocular tasks (such as the ratio of correct rate, reaction time, sensitivity, discrimination threshold, etc.) and binocular functional performance (such as stereo vision, masking degree, integration ability, etc.); The calculation formulas for the degree of attenuation and the degree of interocular suppression are as follows:

Amblyopia input signal attenuation degree (Attenuation Factor, AF) = 1-m4/m3,

Inhibition Factor (IF)=[m4/(m2×m3)] ^N , where N≥1 is a real number, usually N is between 1 and 5, where m2, m3, m4 are the physical attribute values of the second visual pattern, the third visual pattern and the fourth visual pattern respectively.

The functional difference between the amblyopic eye and the non-amblyopic eye: DIFF=m2/m1, where m1 and m2 are the first visual pattern, the third visual pattern and the fourth visual pattern obtained under the same correct rate or reaction time level respectively when performing monocular function measurement physical property values.

Binocular visual function BF=(m1+m2)/2, wherein m1, m2 are the physical attribute values of the first visual pattern and the second visual pattern under the specific correct rate or response level when measuring the binocular function respectively, generally m1=m2.

[S10] Based on the binocular intensity data obtained in step [S9], the function difference data between the amblyopic eye and the non-amblyopic eye, and the binocular vision function data, the control device forms a personalized training task, and obtains monocular intensive training and binocular training for amblyopic patients. Mode and dose, according to the settings and needs, repeat all or part of the steps from step 1 to step 9 until the set threshold or training intensity is reached, and the training is stopped. When the interocular function difference data is less than 20%, the difference between the binocular vision function data and the normal control is less than 20%, the degree of amblyopic eye damage is less than 10%, and the interocular inhibition coefficient is less than 2, consider terminating the training; otherwise, perform step [10] 】.

[S11] During the training process of amblyopia patients, amblyopia patients can send back the training results to professional doctors and training experts through the communication device on a regular basis or according to their own needs, and the doctors or training experts will track and evaluate the training results in real time, and perform training tasks and doses The real-time adjustment is transmitted to the control device through the communication device for training of amblyopia patients.

[S12] During the training process, amblyopic patients can regularly or according to their own needs send back the evaluation of the training participation level of the amblyopic patients to professional doctors, training experts and parents through communication devices, and the doctors or training experts will track and evaluate the training of patients in real time Participation and completion, with human contact if required.

[S13] After completing a training task, the amblyopic patient can repeat steps [S1] to [S9] to conduct quantitative analysis of the visual function of the amblyopic eye and the non-amlyopic eye, the functional characteristics of both eyes, and the mechanism of amblyopia damage, and then proceed to step 10 Judging the degree of difference in function between the amblyopic eye and the non-amblyopic eye, the functional characteristics of both eyes, and the extent of damage, determine whether to continue training and the mode and dose of training.

Example 1

1) The control device issues instructions to present two sinusoidal gratings (hereinafter referred to as binocular gratings) with the same size, average brightness, and spatial frequency but different spatial phases and contrasts to the two eyes of the amblyopic patient through the display device. The spatial phase values of the two binocular gratings are the same, but opposite in polarity. The contrast value of the binocular grating observed by the amblyopic eye is fixed at 100%, and the contrast value of the binocular grating observed by the non-amblyopic eye is a random value within 0-100%. Value m1.

The two binocular gratings correspond to the same retinal spatial position on both eyes of the patient. Therefore, although the phases of the gratings observed by the patient's own eyes are different, the patient can only perceive one sinusoidal grating (hereinafter referred to as the integrated grating) when both eyes observe at the same time.

2) When the patient adjusts the contrast of the binocular grating observed by the non-amblyopic eye through the human-computer interaction device, the phase of the integrated grating perceived by the patient will change accordingly. The patient adjusts the contrast of the binocular grating observed by the non-amblyopic eye through the interactive device until the phase of the integrated grating perceived by the patient reaches the predetermined binocular balance point (zero phase point). The contrast ratio m2 of the binocular grating observed by the eye, m2 is usually less than 100%.

3) The control device issues an instruction and presents the third sinusoidal grating (hereinafter referred to as monocular matching grating 1) at the position of the amblyopic eye of the amblyopic patient on the display device. The sinusoidal grating phase is located at the preset binocular balance point (zero phase point), the contrast value is a random value within 0-100%, and the spatial position is located near but not coincident with the aforementioned two binocular integrated gratings. Therefore, the patient will perceive two sinusoidal gratings at this time, one of which is the aforementioned integrated grating and the other is the monocular matching grating 1 .

4) The patient adjusts the contrast value of the monocular matching grating 1 through the interactive device until the contrast is perceptually close to the aforementioned integrated grating, and the control device records the contrast value m3 of the monocular matching grating 1 at this time.

5) The control device sends an instruction to the display device, so that the display device fades away to eliminate the third visual pattern;

6) The control device sends an instruction to the display device, and presents the fourth sinusoidal grating (hereinafter referred to as monocular matching grating 2) at the position corresponding to the non-amblyopic eye of the amblyopic patient on the display device. The sinusoidal grating phase is located at the preset binocular balance point (zero phase point), the contrast value is a random value within 0-100%, and the spatial position is located near but not coincident with the aforementioned two binocular integrated gratings. Therefore, the patient will perceive two sinusoidal gratings at this time, one of which is the aforementioned integrated grating and the other is the monocular matching grating 2 .

7) The patient adjusts the contrast value of the monocular matching grating 2 through the interactive device until the contrast is perceptually close to the aforementioned integrated grating, and the host control device records the contrast value m4 of the monocular matching grating 2 at this time.

8) According to the previously measured contrast ratio m2 of binocular gratings observed by the non-amblyopic eye when the preset binocular balance point is reached, the contrast value m3 of monocular matching grating 1 and the contrast value m4 of monocular matching grating 2, the patient's personal visual function is impaired. The characteristics were quantitatively analyzed, and the contribution value of the weakening degree of the input signal of the amblyopic eye and the suppression degree of the input signal of the amblyopic eye to the amblyopic eye were respectively given.

The specific calculation method is as follows:

AF (Attenuation Factor) = 1-m4/m3,

IF (Inhibition Factor) = [m4/(m2×m3)] ^N , the degree of inhibition of non-amblyopic eyes on the input signal of amblyopic eyes. The N used can be assigned after a statistical test according to the specific type of physical properties used. In some cases, N can be assigned a value between 2 and 2.5.

9) According to the above-mentioned calculated data, the system generates the mode and dose of monocular intensive training and binocular training for the patient respectively, wherein the binocular training mode is that the contrast ratio of the stimulation input for the amblyopia eye is 100%, and the contrast ratio of the stimulation input for the non-amblyopia eye is 100%. Binocular vision task training for m2, including but not limited to different types of binocular vision tasks such as binocular fusion, competition, correlation, and stereo; monocular intensive training mode is monocular detection or discrimination task training performed by covering the non-amblyopic eye, both The dose ratios were allocated according to the quantified results above.

AF was used as the main criterion, and DIFF and BF were used as auxiliary criteria. Generally, when the weakening degree of the input signal of the amblyopic eye is greater than 10%, the monocular (amblyopic eye) training is preferred, and the training dose is calculated according to 100*INT (90*AF+30) (INT is a rounding function, such as AF=0.36, then The total dose is 6200), and training is carried out at 400-1200 trials/day; if AF≤10%, binocular vision function training is used, and the training dose is min(12000, max(100*INT(IF*10), 100 *INT(90*AF+30)) is calculated, and the training is carried out according to 400-1200 trials/day. Due to the limitations of factors such as age, cognitive level, comprehension ability or cooperation degree, the degree of damage to the amblyopic eye and the When reasonably estimating the degree of inter-interval inhibition, it can be judged based on DIFF: when DIFF<60%, use monocular (amblyopia) visual function strengthening training, and the training dose is calculated according to 100*INT[120*(1-DIFF)], and Train at 400-1000 trials/day; if DIFF>=60%, use binocular vision function training, training dose according to max(3000,100*INT[120*(1-DIFF)]), and press 400- 1000 trials/day for training.

10) At the same time, a communication device is connected to the control device to transmit information to remote personnel (professional physicians and sensory training experts). During the training process, patients can send back the training results to professional doctors and training experts on a regular basis or according to their own needs, and the doctors or training experts can track and evaluate the training results in real time, and make real-time adjustments to the training tasks, modes and doses for better results. good training.

The following are the specific training and effects of two kinds of amblyopia patients of different ages collected according to the above steps.

As shown in the table below, the vision information of a 20-year-old patient with anisometropia was collected and a training test was performed on it. The test results show that m2 = 0.18, m3 = 0.95, m4 = 0.54, according to the formula calculation, the degree of weakening of the input signal of the amblyopic eye is AF = 1-0.64/0.95 = 0.43; the training dose is based on 100*INT (90*AF+30) Calculated, the total dose available is 6800 times. Contrast sensitivity is the most important visual function, and it is also a typical impairment of amblyopia; the contrast sensitivity impairment of this amblyopia child is very significant, and the left eye is amblyopia, so the left eye contrast detection task training is first chosen, and the training is arranged 850 times a day. A total of 8 days of training are required. After 8 times of training, the visual acuity of the amblyopic eye of the amblyopic patient has improved significantly (from 0.6 to 0.8 in the right eye), while the visual acuity of the healthy eye has remained good, and the contrast sensitivity has also been significantly improved (Figure 4); the stereopsis function has also been improved by 50” to 20".

As shown in the table below, the vision information of a 6-year-old child with binocular amblyopia was collected, and a training test was performed on it. The visual acuity and stereopsis information of the patient's eyes were measured by the clinical visual acuity chart and stereopsis test method as shown in the table below. Because the child was too young to complete the relevant measurements of the degree of damage to the amblyopic eye and the degree of interocular inhibition, the plan was determined based on the functional differences of the two eyes. The vision ratio of the right eye and the left eye is 0.3/0.6=0.5, which can be calculated according to the above formula (100*INT[120*(1-0.5)]), and the total training dose is 6000. Contrast sensitivity is the most important visual function, and it is also a typical impairment of amblyopia; the contrast sensitivity impairment of this amblyopic child is very significant (Figure 5), and the right eye is the weaker eye, so the right eye contrast detection task training is selected first, according to 750 trials per training session, a total of 8 training sessions were performed. After 8 times of training, the visual acuity of the left and right eyes of the amblyopia patients has improved significantly (from 0.3 to 0.5 for the right eye, and from 0.6 to 0.8 for the left eye), and the contrast sensitivity has also been significantly improved (Figure 5); the stereoscopic function also has 200” Raised to 60".

Utilize the training system provided by the present invention to train eleven adult patients with amblyopia, as shown in Figure 6, through the training of 8 days on average, improve visual acuity 2 rows on average (in the middle; logMAR visual acuity is lower the better, and 0.1logMAR corresponds to 1 row), and also significantly improved contrast sensitivity (left) and stereopsis (right).

The self-adaptive amblyopia training system and method provided by the present invention are also suitable for visual function impairment training of other diseases such as myopia and presbyopia.

Apparently, the above-mentioned embodiments are only examples for clear description, rather than limiting the implementation. For those of ordinary skill in the art, other changes or changes in different forms can be made on the basis of the above description. It is not necessary and impossible to exhaustively list all the implementation manners here. However, the obvious changes or changes derived therefrom still fall within the scope of protection of the present invention.

Claims (19)

1. A personalized self-adaptive amblyopia training system, which is characterized by comprising a control device, a display device and an interaction device; the control device comprises a visual training task database and a amblyopia damage mechanism quantitative analysis model, a plurality of visual patterns are arranged in the visual training task database, the control device is connected with the display device and the interaction device, and the interaction device is used for adjusting physical properties of visual images observed by a patient with amblyopia through the display device and feeding back the physical properties to the control device;

The control device performs training on the visual patterns according to the recorded representation of the amblyopia patient, and performs quantitative analysis on the visual function damage characteristics of the amblyopia patient through the amblyopia damage mechanism quantitative analysis model to obtain the single-eye and double-eye visual function damage characteristics of the amblyopia patient, the weakening degree of the amblyopia input signals and the inter-eye inhibition degree of the non-amblyopia on the amblyopia input signals; according to the quantitative analysis result of the visual function damage and/or the visual damage mechanism of the monocular and binocular eyes, the control device extracts visual patterns from the visual training task database, generates an individualized visual training task for the patient with the amblyopia, and transmits the individualized visual training task to the display device for the patient with the amblyopia to carry out visual training.

2. The personalized adaptive amblyopia training system according to claim 1, wherein the control device is a device with program execution, data processing and storage functions, comprising a computer (PC, mac), tablet (iPad, etc.), cell phone or any other processor, memory with programmable functions.

3. The personalized adaptive amblyopia training system of claim 1, wherein the display device is a display capable of binocular split vision and/or a device assisting in binocular split vision.

4. A personalized adaptive amblyopia training system according to claim 3, wherein the binocular vision patterns displayed by the display means are identical, similar or complementary vision patterns, and the interaction means can adjust the physical properties of the presented vision patterns to be identical or different.

5. The personalized adaptive amblyopia training system of claim 1, wherein the interactive device is a device that can be used by a user to feedback on a visual training task, which is one of a joystick, a device with multiple keys, a mouse, a reaction box, a touch screen with multiple clickable options.

6. The personalized adaptive amblyopia training system according to claim 1, wherein the visual training task is a visual pattern that stimulates human eye retinal receptor cells and quantifies measured physical properties, including one or a combination of sinusoidal grating, square wave grating, gabor grating, original or filtered numbers/kanji/letters, original or filtered natural stimulus, dots, or visual noise patterns.

7. An adaptive amblyopia training system according to any one of claims 1-6, further comprising a wired or wireless communication device connected to the control device, through which the training results of the amblyopia patient and the results on the training participation assessment task are returned to the amblyopia patient, child patient parents, specialists and perception training specialists, who track and accurately assess the training results and the participation of the amblyopia patient during the training period in real time and personalize the subsequent amblyopia patient training regimen.

8. The personalized adaptive amblyopia training system according to claim 1, wherein the personalized visual training task comprises a training mode and a training dose, the training mode comprises four modes of a monocular visual function training task, a monocular visual function training and binocular visual function training combined task, a binocular visual function training and monocular visual function training combined task, and a binocular visual function training task; training doses were 3000-12000 trials/task and were equally distributed over 5-20 exercises.

9. The personalized adaptive amblyopia training system of claim 1, wherein the interaction means adjusts physical properties of the visual image observed by the amblyopia patient to include one or more physical properties of contrast, brightness, phase, azimuth, angle, orientation, size, color, shape, spatial frequency, temporal frequency, stereoscopic depth, movement speed, movement direction uniformity level, binocular parallax, presentation time, presentation location of the stimulus.

10. A personalized adaptive amblyopia quantitative analysis and adjustment method, characterized in that the method comprises the following steps:

Step 1, a control device extracts visual patterns from a visual training task database to form a visual training task, and transmits the visual training task to a display device for a patient with amblyopia to train a monocular function and/or a binocular function;

step 2, adjusting physical properties of a first visual pattern observed by the amblyopia eye and/or physical properties of a second visual pattern observed by the non-amblyopia eye through an interaction device, judging physical dimensions of the corresponding visual patterns by the amblyopia eye and/or the non-amblyopia eye respectively, and recording and storing physical property values of the first visual pattern observed by the amblyopia eye and/or the second visual pattern observed by the non-amblyopia eye by a control device;

step 3, the control device sends out instructions to the display device, so that the display device can fade to eliminate the first visual pattern or the second visual pattern or simultaneously eliminate the first visual pattern and the second visual pattern, and the control device waits for the amblyopia patient to make task judgment, and records and stores the judgment accuracy or data during reaction;

step 4, the controllable device sends out instructions to the display device according to the needs, so that the display device displays a third visual pattern with different physical properties from the first visual pattern and the second visual pattern to the amblyopia eye of the amblyopia patient, and the spatial position of the third visual pattern on the retina is positioned near the spatial positions of the first visual pattern and the second visual pattern on the retina;

Step 5, according to the requirement, the physical attribute of the third visual pattern observed by the amblyopia patient is regulated by the interaction device until the visual perception of the physical attribute is the same as the pattern after the integration of the first visual pattern and the second visual pattern, and the control device records and stores the physical attribute value of the third visual pattern observed by the amblyopia patient;

step 6, the control device sends out instructions to the display device according to the requirements, so that the display device can fade in and fade out to eliminate the third visual pattern;

step 7, the control device sends an instruction to the display device according to the need, so that the display device displays a fourth visual pattern with different physical properties from the first visual pattern and the second visual pattern to the non-amblyopia eye of the amblyopia patient, and the space position of the fourth visual pattern on the retina is positioned near the space positions of the first visual pattern and the second visual pattern on the retina;

step 8, according to the need, the patient with amblyopia adjusts the physical attribute of the fourth visual pattern observed by the non-amblyopia eye through the interaction device until the visual perception is the same as the visual pattern after the integration of the first visual pattern and the second visual pattern, and the control device records and stores the physical attribute value of the fourth visual pattern observed by the non-amblyopia eye;

Step 9, according to the physical attribute values of the first visual pattern, the second visual pattern, the third visual pattern and the fourth visual pattern or according to the response time or the correct rate data in the step 1-3, the control device quantitatively analyzes the visual function damage characteristics through a amblyopia damage mechanism quantitative analysis model to obtain specific values of the weakening degree of the amblyopia input signals and the inter-eye inhibition degree of the non-amblyopia on the amblyopia input signals, the performance function difference data of the amblyopia eyes and the non-amblyopia on the monocular task and the binocular vision function data;

and step 10, forming an individualized training task by the control device based on the binocular intensity degree data, the amblyopia eye and non-amblyopia eye function difference data and the binocular vision function data obtained in the step 9, obtaining a mode and a dosage of monocular strengthening training and binocular training for the amblyopia patient, repeating all or part of the steps from the step 1 to the step 9 according to the setting and the requirement until the set threshold value or training intensity is reached, and stopping training.

11. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 10, wherein the calculation formula of the weakening degree and the inter-eye suppression degree of the amblyopia input signal in the step 9 is as follows:

The degree of weakening of the amblyopia eye input signal af=1-m 4/m3;

degree of interocular suppression of input signals to the amblyopia by the non-amblyopia eye if= [ m 4/(m2×m3)] ^N Wherein N is a real number greater than or equal to 1;

wherein m2, m3, m4 are physical attribute values of the obtained second, third and fourth visual patterns, respectively.

12. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 10, wherein the method for calculating the functional differences between the amblyopia eyes and the non-amblyopia eyes in step 9 is as follows:

functional differences between amblyopia and non-amblyopia: diff=m2/m 1;

wherein m1 and m2 are physical attribute values of the first visual pattern, the third visual pattern and the fourth visual pattern obtained under the same accuracy or response time level when monocular function measurement is performed.

13. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 10, wherein the calculation method of binocular vision function in step 9 is as follows:

binocular vision function bf= (m1+m2)/2;

wherein m1 and m2 are physical attribute values of the first visual pattern and the second visual pattern at a specific accuracy or reaction level when measuring binocular function, respectively, and m1=m2 is generally taken.

14. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 11, wherein in the step 10, the weakening degree AF of the input signal of the amblyopia eye is used as a main criterion, and the difference DIFF and BF between the functions of the amblyopia eye and the non-amblyopia eye are used as auxiliary criteria;

if the weakening degree AF of the input signal of the amblyopia eye is more than 10%, training is carried out by adopting the strengthening training of the visual function of the single eye (the amblyopia eye), wherein the training dosage is calculated according to 100 INT (90 AF+30), INT is a rounding function, and the training is carried out according to 400-1200 test times per day;

when the weakening degree AF of the input signals of the amblyopia eyes is less than or equal to 10%, training is carried out according to the training dosage calculated according to min (12000, max (100 INT (IF 10), 100 INT (90 AF+30)), and the training is carried out according to 400-1200 test times per day.

15. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 11, wherein when the damage degree and the inhibition degree between eyes cannot be reasonably estimated due to age, cognitive level, comprehension ability or coordination degree and other factors, the method is characterized by comprising the following steps:

if DIFF <60%, training with monocular (amblyopia) vision enhancement, the training dose is calculated as 100 x int [120 x (1-DIFF) ] and training is performed at 400-1000 trials/day;

If DIFF > = 60%, binocular vision function training is used at a training dose according to max (3000, 100 x int [120 x (1-DIFF) ]), and training is performed at 400-1000 trials/day.

16. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 10, further comprising: step 11, in the training process, the amblyopia patient can regularly or according to own needs pass the training result back to the professional doctor and training expert through the communication device, the doctor or training expert tracks and evaluates the training result in real time, and the training result is transmitted to the control device through the communication device after real-time adjustment of the training task and the training dosage, so that the amblyopia patient can be trained.

17. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 16, further comprising: step 12, in the training process, the weak-vision patient can regularly or according to own needs pass back the training participation degree evaluation condition of the weak-vision patient to the professional doctor, training expert and parents through the communication device, and the doctor or training expert tracks and evaluates the training participation and completion condition of the patient in real time and performs manual contact when required.

18. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 17, further comprising: step 13, after finishing a training task, the patient with amblyopia can repeat steps 1-9, carry out quantitative analysis on visual functions, binocular functional characteristics and amblyopia damage mechanisms of the amblyopia eye and the non-amblyopia eye, and then carry out step 10 to judge the difference degree of the functions of the amblyopia eye and the non-amblyopia eye, the binocular functional characteristics and the damage amplitude condition, and determine whether to continue training and the mode and dosage of training.

19. The personalized adaptive amblyopia quantitative analysis and adjustment method according to claim 10, wherein in the step 10, when the difference of the inter-ocular function data is less than 20%, the difference of the binocular vision function data is less than 20% compared with the normal control, the degree of the amblyopia eye damage is less than 10%, the inter-ocular inhibition coefficient is less than 2, the termination of the training is considered; otherwise, repeating the steps 1-10 to continue training.

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