CN110613425A - Setting system for objectively quantifying interocular inhibition degree of crowd - Google Patents

Abstract

The invention relates to the technical field of visual cognition, and relates to a setting system and method for objectively quantifying the degree of suppression between the eyes of a crowd. The black-and-white sine-wave grating induced the subjects' optokinetic nystagmus, which was presented to both eyes through a split-view mirror, and then induced competition between the eyes. Real-time display on the screen, by analyzing the eye movement recorded data and calculating the eye competition balance point, the present invention can objectively and quantitatively evaluate the degree of inhibition between the eyes of the crowd, and solves the problem that the prior art cannot be applied to poor coordination or cannot make subjective judgments. The test problem is improved, the evaluation accuracy of inhibition degree is improved, and the complete dependence of existing methods on population compliance is relieved.

Description

A setup system for objectively quantifying the degree of suppression between the eyes of a population

technical field

The invention relates to the technical field of visual cognition, relates to an ophthalmology method for quantifying the degree of inhibition between people's eyes, and in particular relates to a setting system and method for objectively quantifying the degree of inhibition between people's eyes, so as to evaluate the degree of balance between the eyes.

Background technique

For some ophthalmic diseases, such as Optokinetic Nystagmus (OKN), it is necessary to measure the inhibitory process between the eyes of patients. In clinical ophthalmology practice, the method of quantifying the degree of inhibition between the eyes is often used to evaluate the balance of the eyes. Studies have shown that when a person's eyes receive different visual stimuli, competition occurs between the eyes, and the contrast sensitivity of the suppressed eye decreases overall. The theory of binocular competition proposes that the competition between eyes is the result of the two eyes competing for dominance (or dominance). eye induced inhibition of the contralateral eye. Since the competition between the eyes will induce the occurrence of the inhibition between the eyes, some studies have conducted relevant tests based on this theory. The results show that when the eyes are presented with different visual stimulation patterns, the competition between the eyes will be induced, which will further induce the dominant eye to the contralateral eye. The intensity changes of visual stimuli presented in front of the eyes can determine the real-time competition pattern between the eyes, and the intensity of visual stimuli in turn depends on the physical characteristics designed by the stimulus conditions, including various influencing factors such as contrast. Based on the above theoretical system, further studies have shown that when the intensity of a stimulus is intentionally enhanced, such as an increase in contrast, the dominance of the corresponding stimulus and the dominance of the corresponding presented eye can be enhanced. Based on the above logic chain, other studies have used the creation of binocular competition to induce binocular inhibition. Specifically, the eyes are presented with opposite visual stimuli to induce competition between the eyes, and the binocular competition can be further changed in real time by adjusting the intensity conditions of the visual stimuli. When the contrast conditions of the eyes are different, the intensity of visual stimuli seen by the eyes is unbalanced, and the competition state between the eyes becomes unbalanced, which further causes the dominant eye to inhibit the contralateral eye. .

At present, the existing methods for measuring the degree of inhibition between the eyes in clinical ophthalmology practice are basically subjective methods, including qualitative and quantitative methods, which require the help of relevant measurement and setting tools; the Worth four-point lamp and Bagolini line commonly used in clinical practice Various tools such as scleroscope can only evaluate the degree of inhibition between the eyes subjectively and qualitatively, which is completely dependent on the subjective judgment of the subjects; while quantitative methods, such as the judgment method of the overall orientation sense of the eyes, the judgment method of the overall sense of movement of the eyes, and the integration of the binocular phase The methods, etc. all require the subjects to make subjective judgments, and the cognitive level of the subjects is required to be high. Therefore, there has been a long-term lack of an objective, quantitative, and simple method for evaluating the degree of inhibition between the eyes and related setting tools.

The definition of optokinetic nystagmus (OKN) can be divided into following movement (slow phase) and saccade movement (fast phase). Studies have shown that OKN can be induced by visual stimuli and can be recorded and measured objectively. Yes, there is a corresponding binocular splitting experiment in some studies to verify that the grid visual stimulus moving in the opposite direction can induce binocular competition and OKN alternately appearing in the opposite direction. Other studies also show that the OKN can be directly used to follow the direction of the movement. Objective proof of the dominant direction of movement seen by the subjects during binocular competition; however, none of the above methods can effectively measure the degree of inhibition between the eyes.

Based on the current state of the prior art, the inventor of the present application intends to provide an objective, quantitative and convenient method for evaluating the degree of inhibition between eyes and a related setting system.

SUMMARY OF THE INVENTION

The purpose of the present invention is to solve the deficiencies of the prior art, and to provide an objective method and a setting system and method for quantifying the degree of suppression between the eyes of a population, so as to evaluate the degree of balance between the eyes.

In the present invention, the grid visual stimuli with different contrast ratios moving in opposite directions are designed to be presented to the eyes respectively, inducing the competition between the eyes, and then the occurrence of the OKN direction alternation. By analyzing the OKN record data, it objectively reflects the situation that the eyes are competing for the upper hand. , that is, the state of binocular competition and the degree of inhibition of the dominant eye to the contralateral eye.

The present invention further provides a setting system for objectively quantifying the degree of suppression between the eyes of a crowd. The setting system includes a subject machine 1, a split-view mirror 2, an eye tracker 3, and a main test machine 4. During clinical use: using the subject machine 1 The screen of test machine 1 displayed visual stimuli (black and white sine wave grids with different contrast ratios of opposite motion, as shown in Figure 2) that induced the subjects' optokinetic nystagmus (OKN), which were presented through the split-view mirror 2 respectively. In both eyes, the competition between the eyes is then induced, and the eye movement under different contrast ratio conditions is objectively recorded by the eye tracker 3 and displayed on the screen of the main test machine 4 in real time. The effective contrast ratio at which the eyes compete to reach equilibrium.

The binocular competition equilibrium point obtained in the present invention can be used as an index to objectively quantify the degree of inhibition between the eyes.

The tested machine, the split-view mirror, the eye tracker and the main test machine in the setting system of the present invention are known in the art or can be obtained through commercial channels.

In the present invention, using the screen of the tested machine 1 to display the visual stimulus as shown in Figure 2, the black and white sine wave bars with different contrast ratios of opposite motion (centripetal), wherein the high contrast (contrast 100%) bars One eye of the subject was presented, and different contrasts (contrast 10%-100%) were presented to the other eye of the subject to induce optokinetic nystagmus (OKN). Induce competition between eyes.

In the present invention, by analyzing the eye movement recorded data, calculating the index of objectively quantifying the degree of inhibition between the eyes, which includes: first extracting the target data segment, removing the saccade movement and blinking, and extracting only the following movement; The accumulation time in the OKN direction/the accumulation time in the OKN direction corresponding to the low-contrast image is the OKN direction ratio; according to the ratio and the corresponding contrast ratio condition, a power function curve is fitted, and when the OKN direction ratio is 1, the corresponding contrast ratio between the eyes is defined as The effective contrast ratio, that is, under the condition of this effective contrast ratio, the binocular competition reaches a balanced state, and the calculated binocular competition balance point, that is, the effective contrast ratio when the subject's binocular competition reaches a balanced state, can be used as an objective quantification of the ratio between the eyes. An indicator of the degree of inhibition.

The present invention provides an objective method and setting system for quantifying the degree of suppression between the eyes of a population. After clinical trials, the results show that the present invention has the advantage of being able to objectively and quantitatively evaluate the degree of suppression between the eyes of a population, especially for clinical trials. In scientific research, it provides an objective means to measure the degree of inhibition, which not only can effectively and conveniently quantify the degree of inhibition between the eyes from an objective point of view, but also broadens the scope of clinical application, and solves the problem that the existing methods cannot be applied to poor coordination or cannot be used. The problem of subjects who make subjective judgments improves the evaluation accuracy of the degree of inhibition, relieves the complete dependence of existing methods on population compliance, and is significantly beneficial to clinical practice in the field of ophthalmology and visual cognition, as well as the study of pathogenesis. Explore further.

Description of drawings

Fig. 1 is the structural representation of the setting system of the present invention for objectively quantifying the degree of suppression between the eyes of a crowd,

Among them, 1. The subject machine 2. The split-view mirror 3. The eye tracker 4. The main test machine.

Figure 2 is a schematic representation of the visual stimuli presented.

The present invention will be further described with reference to the accompanying drawings and embodiments.

Detailed ways

Example 1

Provide an evaluation system for objectively quantifying the degree of suppression between the eyes of a crowd. The setting system includes a subject machine 1, a split mirror 2, an eye tracker 3, and a main test machine 4. 1 The screen displays the visual stimuli as shown in Figure 2, the black and white sine wave grids with different contrast ratios of opposite motion (centripetal), in which the high contrast (contrast 100%) grid is presented to the subject's eye, and the low contrast (contrast 100%) %, 80%, 40%, 20% or 10%) were presented to the other eye of the subject to induce optokinetic nystagmus (OKN). The eye movement OKN under different contrast ratio conditions is recorded by the eye tracker 3 and displayed on the screen of the main test machine 4 in real time;

It can be observed from the screen of the main test machine 4 that if the right eye image is dominant in the binocular competition, the OKN direction is from left to right; when the left eye image is dominant, the OKN direction is from right to left, and then the eye movements are extracted and analyzed. Record data, remove saccades and blinks, and extract only following movements;

In this embodiment, the accumulation time in the OKN direction corresponding to the high-contrast image/the accumulation time in the OKN direction corresponding to the low-contrast image is defined as the OKN direction ratio, and a power function curve is fitted according to the ratio and the corresponding contrast ratio condition. When the ratio is 1, the corresponding binocular contrast ratio is the effective contrast ratio, that is, under the condition of this effective contrast ratio, the binocular competition reaches a balanced state. Effective contrast ratio, as an objective quantification of the degree of inhibition between the eyes.

Claims (6)

1. A setting system for objectively quantifying the degree of interocular suppression of a human population, comprising a machine under test (1), a minute vision mirror (2), an eye tracker (3), and a main tester (), wherein: visual stimulation is displayed on a screen of a tested machine (1), black and white sine wave bars with different contrast ratios moving in opposite directions are used for inducing visual dynamic nystagmus (OKN) to be tested, the eye movement tremor (OKN) to be tested is respectively displayed on two eyes through a sight splitting mirror (2), then competition between the two eyes is induced, eyeball movement conditions under different contrast ratio conditions are objectively recorded by an eye movement instrument (3) and displayed on a screen of a main testing machine (4) in real time, and a binocular competition balance point is calculated by analyzing eye movement recorded data, namely the binocular competition reaches the effective contrast ratio under a balance state.

2. The setting system for objectively quantifying the degree of interocular suppression of a human population according to claim 1, wherein the calculated binocular competition balance point is used as an index for objectively quantifying the degree of interocular suppression.

3. The setting system for objectively quantifying the degree of interocular suppression of a human population according to claim 1, wherein the screen of the machine under test (1) is used to display visual stimuli, the bar gratings with different contrast ratios (centripetal) moving in opposite directions show the first eye under test with a high contrast ratio (i.e., a contrast ratio of 100%), the bar gratings with different contrast ratios (i.e., a contrast ratio of 10% to 100%) show the other eye under test, so as to induce the kinetic nystagmus (OKN) under test, the visual stimuli respectively show the two eyes through the sight glass (2), and then the competition between the two eyes is induced.

4. The setting system for objectively quantifying binocular suppression of human beings according to claim 1, wherein an index for objectively quantifying the binocular suppression is calculated by analyzing the eye movement record data, which includes first extracting a target data segment, removing saccadic motion and blink, and extracting only follow-up motion; defining the accumulation time in the OKN direction corresponding to the high-contrast image/the accumulation time in the OKN direction corresponding to the low-contrast image as an OKN direction ratio; and fitting a power function curve according to the ratio and a corresponding contrast ratio condition, and defining the corresponding binocular contrast ratio as an effective contrast ratio when the OKN direction ratio is 1, namely under the condition of the effective contrast ratio, the binocular competition reaches an equilibrium state, and calculating a binocular competition equilibrium point, namely the effective contrast ratio when the tested binocular competition reaches the equilibrium state.

5. The setting system for objectively quantifying the degree of interocular suppression of a human population according to claim 4, wherein the ratio of the effective contrast ratio of the two tested eyes competing to reach the equilibrium state is used as an index for objectively quantifying the degree of interocular suppression.

6. A method for objectively quantifying the degree of suppression between two eyes of a crowd is characterized by comprising the steps of designing bar grid visual stimuli with different contrast ratios of motions in opposite directions to be respectively presented to the two eyes to induce binocular competition, further enabling visual dynamic nystagmus (OKN) direction alternate transformation to occur, and objectively reflecting the situation that the two eyes compete for dominance through analyzing the OKN recorded data, namely the state of binocular competition and the degree of suppression of the dominant eye to the opposite eye.