CN1161511C - Long-acting wide-spectrum antiseptic nanometer silver fabric and its making method - Google Patents
Long-acting wide-spectrum antiseptic nanometer silver fabric and its making method Download PDFInfo
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- CN1161511C CN1161511C CNB991111559A CN99111155A CN1161511C CN 1161511 C CN1161511 C CN 1161511C CN B991111559 A CNB991111559 A CN B991111559A CN 99111155 A CN99111155 A CN 99111155A CN 1161511 C CN1161511 C CN 1161511C
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- 239000004744 fabric Substances 0.000 title claims abstract description 77
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 35
- 239000004332 silver Substances 0.000 title claims abstract description 35
- 230000002421 anti-septic effect Effects 0.000 title claims description 22
- 238000001228 spectrum Methods 0.000 title claims description 21
- 238000000034 method Methods 0.000 title description 11
- 239000000835 fiber Substances 0.000 claims abstract description 10
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical group [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 208000015181 infectious disease Diseases 0.000 claims abstract description 4
- 206010052428 Wound Diseases 0.000 claims abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 3
- 229910001923 silver oxide Inorganic materials 0.000 claims abstract description 3
- 206010040872 skin infection Diseases 0.000 claims abstract description 3
- 239000002245 particle Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 13
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 101710134784 Agnoprotein Proteins 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 238000005098 hot rolling Methods 0.000 claims description 6
- 229910052742 iron Inorganic materials 0.000 claims description 6
- 239000007800 oxidant agent Substances 0.000 claims description 6
- 230000001590 oxidative effect Effects 0.000 claims description 6
- 241000233866 Fungi Species 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 208000002847 Surgical Wound Diseases 0.000 claims description 2
- 206010053615 Thermal burn Diseases 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- 230000000472 traumatic effect Effects 0.000 claims description 2
- 239000000675 fabric finishing Substances 0.000 claims 2
- 238000009962 finishing (textile) Methods 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 15
- 239000011882 ultra-fine particle Substances 0.000 abstract 2
- 208000014674 injury Diseases 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 201000009862 superficial mycosis Diseases 0.000 abstract 1
- 239000002344 surface layer Substances 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 description 25
- 241000894006 Bacteria Species 0.000 description 20
- 239000000243 solution Substances 0.000 description 19
- 238000012360 testing method Methods 0.000 description 18
- 230000001580 bacterial effect Effects 0.000 description 11
- 229920000742 Cotton Polymers 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000003112 inhibitor Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000003115 biocidal effect Effects 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 206010041925 Staphylococcal infections Diseases 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000001408 fungistatic effect Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 229920002972 Acrylic fiber Polymers 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000193468 Clostridium perfringens Species 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241000589516 Pseudomonas Species 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000122973 Stenotrophomonas maltophilia Species 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- -1 copper sulfide compound Chemical class 0.000 description 2
- 229960003276 erythromycin Drugs 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 241000589291 Acinetobacter Species 0.000 description 1
- 241000607528 Aeromonas hydrophila Species 0.000 description 1
- 241000607522 Aeromonas sobria Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000588986 Alcaligenes Species 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000222173 Candida parapsilosis Species 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- JFPVXVDWJQMJEE-QMTHXVAHSA-N Cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)C(=NOC)C1=CC=CO1 JFPVXVDWJQMJEE-QMTHXVAHSA-N 0.000 description 1
- 241000588923 Citrobacter Species 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000588697 Enterobacter cloacae Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241001360526 Escherichia coli ATCC 25922 Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 241000588771 Morganella <proteobacterium> Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000607265 Vibrio vulnificus Species 0.000 description 1
- 241000222126 [Candida] glabrata Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 241000933979 bacterium 14 Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229940055022 candida parapsilosis Drugs 0.000 description 1
- 229960001139 cefazolin Drugs 0.000 description 1
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
- GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 description 1
- 229960004261 cefotaxime Drugs 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000002682 general surgery Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- RNQBLUNNAYFBIW-NPULLEENSA-M hexadecyl(trimethyl)azanium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate Chemical compound COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O.CCCCCCCCCCCCCCCC[N+](C)(C)C RNQBLUNNAYFBIW-NPULLEENSA-M 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 229940046284 zinacef Drugs 0.000 description 1
Landscapes
- Chemical Or Physical Treatment Of Fibers (AREA)
Abstract
The present invention discloses a nano silver antibacterial functional fabric with long action and a broad spectrum. Ultrafine particle silver is attached between the fibers or to the fibers of the fabric, the surface layer of the ultrafine particle silver is silver oxide, the core is metal silver, and the particle diameter is from 1 to 100 nanometers. The fabric can be used as an article for daily use for people, and can be used as the functional fabric for treating the skin infections and skin superficial mycosis infections for patients with traumas, and preventing and treating the infections of incisional wounds after the incision operations of surgical operations.
Description
The invention relates to a kind of antiseptic fabric and manufacture method thereof, more particularly, is about a kind of long-acting wide-spectrum antiseptic nanometer silver fabric and manufacture method thereof, is that the patent No. is 92109288.1 continuity patent, international Patent classificating number D06M13/00.
Functional textile be this century the eighties at first propose by Germany scientist, and meet with a response in developed country rapidly, countries in the world have all been dropped into substantial contribution and have been researched and developed, and come out and are applied to clinical at portable existing procucts on the medicinal functional fabric of human body so far; But do not see breakthrough in the medicinal functional fabric of human body at Nonimplantation, the definition that main cause is to define this fabric must be carrier with the fabric, good stability, to the treatment of human body diseases ultra high efficiency, long-acting, low toxicity and auxiliary curing function or the like, the sort of anything but simple the sort of notion that sprinkles with the medicine dip-coating comes down to a kind of brand-new novel " stype ".
In the clear 54-151669 of Japan Patent, a kind of bactericidal properties cloth is disclosed, its compound resin solution independent or mixture that will contain copper, silver (6 microns of average grain diameters) is handled yarn, be made into bactericidal properties cloth again after making this solution evenly be coated on the surface of yarn, this product can be made the lining of rubber boot, canvas shoes and socks.
In Japan " process technology " vol.17 NO7 report, handle acrylic fiber with copper and sulfide, get acrylic fibers one copper sulfide compound, it has bacteriostasis to staphylococcus aureus, Escherichia coli, hay bacillus, the thread tinea alba bacterium of skin.
At Chinese invention patent CN87100231A, exercise question is " antibiotic deodorant fabric and a manufacture method ", open day: disclose a kind of antibiotic fabric in 18 days November in 1987, it is with acrylic fabric priority and Cu+, Viride Nitens 4 composite crosslinkings, product has bacteria resistance function to 10 bacterial classifications such as staphylococcus aureus, MRSA, white Portugal coccus, Candida albicanss, and it can be used as underwear, socks, shoe-pad and the medical industry of antibacterial deodourizing, the Work Clothes of food industry.
In the flat 3-136649 of Japan Patent, the applying date: disclose a kind of anti-bacteria cloth that prevents mastitis for milk cows in 24 days October in 1989.It is compound with the coordinate bond form with silver ion and polyacrylonitrile, and product has inhibitory action to 6 kinds of bacterial classifications such as streptococcus, staphylococcus, can be used as the anti-bacteria cloth of wiping cow breast nipple with the mammitis of prevention milk cow.
More than these products antibacterial action is all arranged, but antimicrobial spectrum is wide, effect is not obvious, and different fully with the present invention.
One of purpose of the present invention provides a kind of antiseptic fabric and manufacture method thereof.
Two of purpose of the present invention provides a kind of long-acting wide-spectrum antiseptic nanometer silver fabric.
Three of purpose of the present invention provides a kind of manufacture method of long-acting wide-spectrum antiseptic nanometer silver fabric.
These and other objects of the present invention will and be described and further set forth by following detailed description.
In long-acting wide-spectrum antiseptic nanometer silver fabric of the present invention, be attached with ultra micron silver between the fiber of fabric or on the fiber, the superficial layer of ultra micron silver is a silver oxide, and core is an argent, and the ultra micron silver granuel directly is 1～100 nanometer; Between the fiber of fabric or the amount of the ultra micron silver that adheres on the fiber be 2～200 micrograms/centimetre
2
The preparation method of long-acting wide-spectrum antiseptic nanometer silver fabric of the present invention comprises adding fabric then by the formulated finishing agent, moisteningly evenly take out to squeeze and go redundant solution, press with electric iron or hot-rolling machine and be Huang to fabric and exhaust look, washing is repeatedly pressed smooth more again; Finishing agent contains: (in 200 kilograms of fabrics)
AgNO
32～40 kilograms, NH
3H
210～30 liters of O,
20～50 liters in oxidant, C
6H
12O
62～40 kilograms.
Further, finishing agent of the present invention comprises: (in 200 kilograms of fabrics)
AgNO
32～40 kilograms, NH
3H
210～30 liters of O,
0.8～4 kilogram of NaOH, 20～50 liters in oxidant,
NH
4NO
310～30 kilograms, C
6H
12O
62～40 kilograms,
HNO
30.2～0.5 liter, C
2H
520～50 liters of OH,
Surplus is that water amounts to 1000 liters.
Wherein, oxidant can be H
2O
2, KCLO
4, NaCLO
4, HCLO
4, (HNO
3+ HCL), (NaCL+HNO
3), (NH
4CL+HNO
3), (KCL+HNO
3), the HNO of being fuming
3, fresh chlorine water, (H
2O
2+ HNO
3), (MnO
2+ HNO
3), (KMnO
4+ HCL), NaCLO, can be used alone, also can use its mixture.
Reaction mechanism is:
Antifungal mechanism:
The nonactive enzyme of organized enzyme
Ag
+Sulfydryl-SH easy and in the electronegative bacterioprotein combines, the organized enzyme loss of activity that some bacteriums are depended on for existence, thus reach fungistatic effect.
Long-acting wide-spectrum antiseptic nanometer silver fabric of the present invention, can be used as medical (outward) functional fabric of treatment burn and as the functional fabric of the skin infection of treatment traumatic patient, and can be used as functional fabric that the treatment superficial skin fungus infects and as the prevention of surgical incision postoperative with treat the functional fabric of infection of incisional wound.
In the present invention, according to classical theory, silver has bactericidal action preferably, and sterilization mechanism is:
Silver is more stable material, substantially water insoluble, and the sterilizing power of itself and antimicrobial spectrum were both so wideless so by force yet, this is bad solution in macrocosm, so must in the microcosmos of nano science, seek answer, be applied to clinical in treatment of diseases and the prevention.The Nano Silver technology is the product that is based upon on quantum chemistry, materials chemistry, the biochemistry three big basic subjects, by with the granular on the material yardstick of silver, makes it reach 10
-9The nanometer scale of m, make full use of its skin effect, small-size effect and utilize various new specific physique and the effect that are different from macrocosm silver that it reflects, realize that it is long-lasting, broad spectrum activity, antibiotic strong, good stability, chance water effect not only do not weaken, the characteristic of Zeng Qianging and in killing the process of pathogenic bacteria on the contrary is not subjected to influence or the like the characteristic of human body acid-base degree.The penetrability of silver is strengthened simultaneously, promotes promoting regeneration of tissue for astringency, brings into play its treatment function.Because its surface area increases greatly, bigger variation also takes place in surface texture, and surface-activity strengthens greatly, and show high specific function, after testing, be 0.16～8.97 mg/ml to the MIC of pathogenic bacteria, MBC is 3.05～81.97 mg/ml, and its sterilizing ability has improved more than 200 times.
The Nano Silver fabric that applying nano silver fabrication techniques goes out is with a wide range of applications on the medicinal functional fabric of human body at Nonimplantation, is applied to go back preventable disease simultaneously body surface, the membrane disease except that being made into various antiseptic dressings; In addition, more extensive on the various antibacterial products Application and Development of human lives, work, as be made into various antibiotic clothes, bedding, socks footwear or the like textiles, light industrial goods and hospital equipment etc.We can say that the application of Nano Silver will make the human lives that the raising of a matter be arranged, Nano Silver medicinal functional fabric will start one and take turns new Industrial Revolution, will promote shooting up and developing of medicinal functional fabric industry.
Long-acting wide-spectrum antiseptic nanometer silver fabric of the present invention (hereinafter to be referred as LBDF) is through test, and every index is as follows:
1, long-lasting:
Make extracorporeal bacteria inhibitor test with the LBDF original without any processing through following 3 kinds of modes again after handling, the result confirms that treated LBDF and its fungistatic effect of LBDF original are constant substantially.
(1) washing is 50 times, washes clear water rinsing, totally 50 times by rubbing with the hands with soap is manual at every turn;
(2) washing is 100 times, only washes by rubbing with the hands totally 100 times with cleaning at every turn;
(3) LBDF steeps (changing water every day) through 45 days water logging.
2, broad spectrum activity:
(1) extracorporeal bacteria inhibitor test of LBDF:
LBDF is carried out MH flat board (or Colombia's agar plate or blood plate) extracorporeal bacteria inhibitor test, and identification of strains and drug sensitive test are with the French Vitek-32 of Biomerieux SA microorganism fully-automatic analyzer.Test specimen comprises the LBDF original of not doing any processing and the LBDF that handles through aforementioned (1), (2).The bacterial classification of extracorporeal bacteria inhibitor test comprises that gram-positive bacteria, Gram-negative bacteria, fungi and brood cell etc. amount to more than 40 pathogenic species.The result proves that LBDF shows obvious bacteria resistance function to these more than 40 bacterial classifications, and these more than 40 bacterial classifications remove that a few is arranged is the international standard bacterial strain, and great majority are bacterial strains of separating from patient's secretion, and its antibacterial difficulty is bigger.
Above extracorporeal bacteria inhibitor test is to be detected by prominent domestic units such as medicine test center Microbiological Lab of the entire PLA of the Chinese People's Liberation Army, Huashan hospital of Shanghai Medical Univ Bacteriology Rooms.
The antibacterial result of LBDF antibiotic fabric and 8 kinds of antibacterials
LBDF antibiotic fabric and control group bacteriostatic diameter (mm) antibacterials MIC method drug sensitivity tests
The big ring third of the negative benzene azoles ammonia benzyl cephalo cephalo cephalo celebrating of bacterium name source washing washing
Do not wash erythromycin
The 50 times 100 times husky stars of contrast XiLin, XiLin his pyridine mycin of azoles quinoline furan oxime
Staphylococcus aureus ATCC25923 18 15 15 7 24 S S S S S S S
Escherichia coli ATCC25922 13 13 12 7 10 S S S S S S
Pseudomonas aeruginosa ATCC27853 12 12 12 76 S S S
C.perfringens CMCC (B) 64,606 10
Staphylococcus aureus (MRSA) secretion 17 15 15 76 R R R R R R R
Staphylococcus epidermidis (MRSE) secretion 18 15 16 76 R R R R R R R
Micrococcus scarlatinae secretion 98876 S S S S S S S
Diplococcus gonorrhoeae secretion 10 10 10 7 31 S S S S S S
Escherichia coli secretion 17 14 14 76 R R R R R R
Enterobacter cloacae secretion 9887 11 R R R R R R
Clostridium perfringen secretion 14 12 13 76 R R R R R R
Pseudomonas aeruginosa secretion 15 15 15 76 R R R R R R
Stenotrophomonas maltophilia secretion 14 13 14 76 R R R S R S
Acinetobacter bauamnnii secretion 13 12 12 7 19 R R R S S S
Klebsiella Pneumoniae secretion 15 14 14 76 R R R S R S
Serratia marcesens secretion 16 13 14 76 R R R R R S
Take labor ground citrobacter secretion 11 10 11 76 R R R R R R
Thunder amasss Pu Luoweideng bacterium secretion 15 13 13 76 R R R S R S
Aeromonas hydrophila secretion 13 11 13 7 16 R R R S R S
Aeromonas sobria secretion 14 12 12 7 17 R I I S R S
Vibrio vulnificus secretion 17 15 15 76 R R R S I S
Proteus mirabilis secretion 11 10 10 79 R R R S R R
Proteus vulgaris secretion 11 9 11 76 R R R S R R
Pan Shi proteus secretion 10 9 10 76 R R I S R S
Candida albicans secretion 21 20 20 76
Candida tropicalis secretion 18 17 18 76
Candida parapsilosis secretion 20 19 20 76
Torulopsis glabrata secretion 27 26 26 76
Annotate: S: responsive I: the R of intermediary: resistance
The blank AB fabric of bacterial strain LBDF fabric
Fabric is washed 20 sub-high pressures and is not washed height and compress and wash and wash for 20 times 50 times
Pseudomonas aeruginosa----15 13 16 16
Staphylococcus aureus----15 17 15 15
Escherichia coli----13 14 18 15
MRSA - - - - 14 14 17 15
Wax-shaped bacillus---11 13 13 15 15
Vibrio vulnificus----16 16 16 17
Candida albicans-21--11 11 11 11
B group hemolytic streptococcus----11 11 12 11
Pseudomonas Maltophilia----12 12 15 14
Nitrate-negative bacillus----14 14 13 15
Moscow' paratyphi C-12--12 14 19 14
Arizona bacterium----14 14 15 14
Citrobacter----14 14 15 13
Pneumobacillus----13 13 17 13
Hay bacillus----12 12 12 12
Morganella morganii---10 12 12 12 12
Alcaligenes faecalis----14 12 16 16
Si Shi Pu Tufeideng Salmonella----12 12 14 13
Enterobacter cloacae----13 13 13 13
Gonococcus----11 11 11 11
Above result shows, LBDF all has inhibitory action to 20 strain bacteriums, and the bacterium that commute develops immunity to drugs, as staphylococcus aureus persister (MRSA), Pseudomonas aeruginosa, Pseudomonas Maltophilia and nitrate-negative bacillus etc. all have inhibitory action, high pressure and wash 20 times and 50 times after all with without the washing the same, bacteriostasis there is not obvious influence, and the AB fabric is after washing 20 times, can not suppress above bacterium, this shows, the two AB fabrics of the scope of restraining fungi of LBDF fabric extensively and not can influence fungistatic effect because of washing.
3, LBDF has excellent bacteriostasis property to the drug resistance pathogenic bacteria
LBDF and 8 antibacterials are made extracorporeal bacteria inhibitor test to 28 pathogenic bacteria simultaneously, the result shows that LBDF all shows tangible bacteria resistance function to 28 bacterial classifications, erythromycin only has bacteria resistance function to 8 bacterial classifications, Oxacillin (2), ampicillin (4), cephazoline (4), Zinacef (4), cefotaxime (15), gentamicin (6), Ciprofloxacin (14).
The extracorporeal bacteria inhibitor test that experimental results show that LBDF and these 8 antibacterials compares, and the bacteria resistance function that LBDF has a clear superiority in to chemical sproof bacterial classification is described.
4, pharmacokinetic
With cavy and rabbit is subjects, and LBDF is to skin acute toxicity test, irritant test, hypersensitive test.Test unit: hospital general's pharmacology section of Nanjing Military Command.Result of the test proof LBDF avirulence, nonirritant, no anaphylaxis.
5, clinical verification
Carried out clinical verification through after the above-mentioned test, existing existing:
(1) 50 clinical reports that a burn case of hospital general, Chinese People's Liberation Army Nanjing Burn and Plastic Surgery Dept. work.
(2) clinical report of the II class otch clinical follow of Jiangsu Prov. People's Hospital department of general surgery work.
(3) clinical report of the superficial skin fungus of Inst. of Dermatology, Chinese Academy of Medical Sciences's work.
Also have hospital of a few family that clinical testings such as skin-grafting area, tumour otch clinical follow, burn and scald, skin ulcer observation are carried out in addition.
Below further specify the present invention by specific embodiment, but embodiment only be used for the explanation, can not limit the scope of the invention.
In the present invention, if not refer in particular to, all parts, amount are the unit of weight based on gross weight.
Example 1
Take by weighing AgNO
310 kilograms, be dissolved in 400 premium on currency, add dense NH
3H
215 liters of O, dense NaOH3 kilogram, NH
4NO
320 kilograms make it to dissolve and mix.Get 10 kilograms of glucose, be dissolved in 50 premium on currency, again enriching HNO
30.1 rise 30 liters of ethanol.With these two kinds of solution mixings, before adding 100 kilograms of pure cotton fabrics, on-the-spot preparation NACL+HNO
3(in molar ratio) solution is 25 liters, 100 kilograms of COTTON FABRIC are immersed Treatment Solution respectively, soaked 5 minutes, under room temperature (20 ℃), stir and make it fully moistening even, take out the back and squeeze and go excessive solution, press with electric iron or hot-rolling machine then and present Huang to fabric and exhaust look, through repeatedly water washing, press smoothly again, promptly get product of the present invention.
Example 2
Take by weighing AgNO
31 kilogram, be dissolved in 400 premium on currency, add dense NH
3H
20.5 kilogram of 5 liters of O, dense NaOH, NH
4NO
35 kilograms make it to dissolve and mix.Get 0.2 kilogram of glucose, be dissolved in 50 premium on currency, again enriching HNO
30.1 rise 15 liters of ethanol.With these two kinds of solution mixings, before adding 100 kilograms of pure cotton fabrics, 10 liters of on-the-spot preparation hydrogen peroxide solutions immerse Treatment Solution respectively with 100 kilograms of COTTON FABRIC, soak 5 minutes, under room temperature (30 ℃), stir and make it fully moistening even, take out the back and squeeze and go excessive solution, press with electric iron or hot-rolling machine then and present Huang to fabric and exhaust look, through repeatedly water washing, press smoothly again, promptly get product of the present invention.
Example 3
Take by weighing AgNO
320 kilograms, be dissolved in 400 premium on currency, add dense NH
3H
230 liters of O, dense NaOH3 kilogram, NH
4NO
330 kilograms make it to dissolve and mix.Get 15 kilograms of glucose, be dissolved in 50 premium on currency, again enriching HNO
30.2 rise 40 liters of ethanol.With these two kinds of solution mixings, before adding 100 kilograms of pure cotton fabrics, 50 liters of the fresh chlorine water solution of on-the-spot preparation immerse Treatment Solution respectively with 100 kilograms of COTTON FABRIC, soak 4 minutes, under room temperature (30 ℃), stir and make it fully moistening even, take out the back and squeeze and go excessive solution, press with electric iron or hot-rolling machine then and present Huang to fabric and exhaust look, through repeatedly water washing, press smoothly again, promptly get product of the present invention.
Example 4
Take by weighing AgNO
315 kilograms, be dissolved in 400 premium on currency, add dense NH
3H
224 liters of O, dense NaOH2 kilogram, NH
4NO
326 kilograms make it to dissolve and mix.Get 12 kilograms of glucose, be dissolved in 50 premium on currency, again enriching HNO
30.2 rise 30 liters of ethanol.With these two kinds of solution mixings, before adding 100 kilograms of pure cotton fabrics, on-the-spot preparation (NH
4CL+HNO
3) and (KCL+HNO
3) mixed solution 40L, NH
4CL and HNO
3, KCL and HNO
3Ratio be mol ratio, (NH
4CL+HNO
3) and (KCL+HNO
3) ratio be 1: 1.5,100 kilograms of COTTON FABRIC are immersed Treatment Solution respectively, soaked 4 minutes, under room temperature (30 ℃), stir and make it fully moistening even, take out the back and squeeze and go excessive solution, press with electric iron or hot-rolling machine then and present Huang to fabric and exhaust look, through repeatedly water washing, press smoothly again, promptly get product of the present invention.
Claims (10)
1, a kind of long-acting wide-spectrum antiseptic nanometer silver fabric is characterized in that being attached with ultra micron silver between the fiber of fabric or on the fiber, and the superficial layer of ultra micron silver is a silver oxide, and core is an argent, and its particle diameter is 1～100 nanometer.
2, long-acting wide-spectrum antiseptic nanometer silver fabric as claimed in claim 1, it is characterized in that between the fiber of fabric or the amount of the ultra micron silver that adheres on the fiber be 2～200 micrograms/centimetre
2
3, as the preparation method of claim 1,2 described long-acting wide-spectrum antiseptic nanometer silver fabrics, it is characterized in that by the formulated finishing agent, add fabric then, moistening even, take out to squeeze and go redundant solution, press with electric iron or hot-rolling machine and to be Huang to fabric and to exhaust look, washing is repeatedly pressed smooth more again.
4, the preparation method of long-acting wide-spectrum antiseptic nanometer silver fabric as claimed in claim 3 is characterized in that containing in 200 kilograms of fabric finishing agents:
AgNO
32～40 kilograms, NH
3H
210～30 liters of O,
20～50 liters in oxidant, C
6H
12O
62～40 kilograms.
5, the preparation method of long-acting wide-spectrum antiseptic nanometer silver fabric as claimed in claim 4 is characterized in that comprising in 200 kilograms of fabric finishing agents:
AgNO
32～40 kilograms, NH
3H
210～30 liters of O,
0.8～4 kilogram of NaOH, 20～50 liters in oxidant,
NH
4NO
310～30 kilograms, C
6H
12O
62～40 kilograms,
HNO
30.2～0.5 liter, C
2H
520～50 liters of OH,
Surplus is that water amounts to 1000 liters.
6,, it is characterized in that oxidant can be H as the preparation method of claim 3,4 described long-acting wide-spectrum antiseptic nanometer silver fabrics
2O
2, KCLO
4, NaCLO
4, HCLO
4, (HNO
3+ HCL), (NaCL+HNO
3), (NH
4CL+HNO
3), (KCL+HNO
3), the HNO of being fuming
3, fresh chlorine water, (H
2O
2+ HNO
3), (MnO
2+ HNO
3), (KMnO
4+ HCL), NaCLO, can be used alone, also can use its mixture.
7,, it is characterized in that can be used as medical (outward) functional fabric of treatment burn and scald as claim 1,2 described long-acting wide-spectrum antiseptic nanometer silver fabrics.
8,, it is characterized in that can be used as the skin infection of treatment traumatic patient and the functional fabric that superficial skin fungus infects as claim 1,2 described long-acting wide-spectrum antiseptic nanometer silver fabrics.
9,, it is characterized in that can be used as the functional fabric of prevention of surgical incision postoperative and treatment infection of incisional wound as claim 1,2 described long-acting wide-spectrum antiseptic nanometer silver fabrics.
10, as claim 1,2 described long-acting wide-spectrum antiseptic nanometer silver fabrics, it is characterized in that can be used as daily living article.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991111559A CN1161511C (en) | 1999-07-27 | 1999-07-27 | Long-acting wide-spectrum antiseptic nanometer silver fabric and its making method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991111559A CN1161511C (en) | 1999-07-27 | 1999-07-27 | Long-acting wide-spectrum antiseptic nanometer silver fabric and its making method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1241662A CN1241662A (en) | 2000-01-19 |
| CN1161511C true CN1161511C (en) | 2004-08-11 |
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ID=5274915
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| US6719987B2 (en) | 2000-04-17 | 2004-04-13 | Nucryst Pharmaceuticals Corp. | Antimicrobial bioabsorbable materials |
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| US7255881B2 (en) | 2000-07-27 | 2007-08-14 | Nucryst Pharmaceuticals Corp. | Metal-containing materials |
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| US6989157B2 (en) | 2000-07-27 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Dry powders of metal-containing compounds |
| AU2001278322B2 (en) | 2000-07-27 | 2005-12-22 | Smith & Nephew (Overseas) Limited | Treatment of hyperproliferative skin disorders and diseases |
| US7001617B2 (en) | 2001-04-23 | 2006-02-21 | Nueryst Pharmaceuticals Corp. | Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals |
| US20030185901A1 (en) | 2000-07-27 | 2003-10-02 | Burrell Robert E. | Methods of treating conditions with a metal-containing material |
| AU2000268169A1 (en) * | 2000-09-01 | 2002-03-13 | Shanghai Lange Scientific Development Co., Ltd. | A nanometre-silver, long-acting, broad spectrum, antimicrobial, mouldproof granule and its producing methods |
| CN100334292C (en) * | 2001-01-20 | 2007-08-29 | 南京希科纳米医药技术有限公司 | Nanometer silver antiseptic yarn and its production process |
| CN1179646C (en) * | 2001-04-20 | 2004-12-15 | 朱红军 | Aggregation-preventing nanometer wide-spectrum antibacterial silve powder and its inductrial production process |
| DE60210441T2 (en) | 2001-04-23 | 2006-11-16 | Nucryst Pharmaceuticals Corp., Fort Saskatchewan | MEDICAMENT OR PLASTER CONTAINS A METAL SUCH AS SILVER, GOLD, PLATINUM OR PALLADIUM AS AN ANTIMICROBIAL ACTIVE INGREDIENT AND ITS USE IN THE TREATMENT OF SKIN INFUSION |
| CN1156624C (en) * | 2001-06-22 | 2004-07-07 | 朱红军 | Aggregation-preventing wide-spectrum antiseptic nanometer silver knitted article and fabric and their industrial production process |
| US7048771B2 (en) * | 2001-10-22 | 2006-05-23 | University Of California | Dyeing textiles using nanoparticles |
| US6979491B2 (en) * | 2002-03-27 | 2005-12-27 | Cc Technology Investment Co., Ltd. | Antimicrobial yarn having nanosilver particles and methods for manufacturing the same |
| US7201925B2 (en) | 2002-04-23 | 2007-04-10 | Nueryst Pharmaceuticals Corp. | Treatment of ungual and subungual diseases |
| US7745509B2 (en) | 2003-12-05 | 2010-06-29 | 3M Innovative Properties Company | Polymer compositions with bioactive agent, medical articles, and methods |
| CN100344824C (en) * | 2004-10-18 | 2007-10-24 | 香港理工大学 | A kind of fabric functional finishing auxiliary agent and its preparation and application method |
| WO2009085651A1 (en) | 2007-12-20 | 2009-07-09 | Nucryst Pharmaceuticals Corp. | Metal carbonate particles for use in medicine and methods of making thereof |
| CN102400306B (en) * | 2010-09-14 | 2015-05-13 | 龚森淼 | Superfine grain silver oxide long-acting broad-spectrum antibacterial fabric and production method thereof |
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1999
- 1999-07-27 CN CNB991111559A patent/CN1161511C/en not_active Expired - Lifetime
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|---|---|
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