CN116035935A

CN116035935A - Anti-dandruff and antipruritic composition and preparation method thereof, shampoo and preparation method thereof, and medicament

Info

Publication number: CN116035935A
Application number: CN202310195007.2A
Authority: CN
Inventors: 金盛; 许桂萍; 李泽谊
Original assignee: Zhaoqing Dicai Daily Chemical Science And Technology Co ltd
Current assignee: Zhaoqing Dicai Daily Chemical Science And Technology Co ltd
Priority date: 2023-03-01
Filing date: 2023-03-01
Publication date: 2023-05-02
Anticipated expiration: 2043-03-01
Also published as: CN116035935B

Abstract

The application relates to the field of shampoo products, in particular to a composition for removing dandruff and relieving itching, a preparation method of the composition, shampoo, a preparation method of the shampoo and a medicament. The composition comprises: 0.1-2 parts of polyglycerol-10 laurate; 0.04-0.15 part of dichlorobenzyl alcohol; 0.1-2 parts of sodium salicylate; 0.05-2 parts of allantoin; 0.05-2 parts of sodium lactate C12-13. The components are synergistic by mutually matching polyglycerol-10 laurate, dichlorobenzyl alcohol, sodium salicylate, allantoin and sodium lactate C12-13, so that the effects of removing dandruff and relieving itching are generated; the anti-dandruff and antipruritic composition provided by the embodiment of the application reduces skin inflammation by inhibiting fungi such as malassezia, and simultaneously repairs skin barriers, nourishes scalp, can improve anti-dandruff and antipruritic effects, reduce irritation to scalp, nourish and moisten gently, and simultaneously has certain conditioning property to hair.

Description

Anti-dandruff and antipruritic composition and preparation method thereof, shampoo and preparation method thereof, and medicament

Technical Field

The application relates to the field of shampoo products, in particular to a composition for removing dandruff and relieving itching, a preparation method of the composition, shampoo, a preparation method of the shampoo and a medicament.

Background

Dandruff are fine white or grey scales that accumulate on the surface of the scalp. Dandruff is closely related to stratum corneum dysfunction. Most of the dandruff is believed to be caused by malassezia fungal infections. Malassezia is a lipophilic fungus, is a normal flora of the scalp, and is distributed on the surface of the scalp through a pilosebaceous canal under the influence of androgens after puberty, and after the malassezia ingests sebum, a large amount of malassezia is propagated, free fatty acids are generated, and the fatty acids penetrate into the stratum corneum to damage the skin barrier. Disruption of the barrier in turn results in excessive synthesis and secretion of sebum, which in turn provides a rich diet for the proliferation of malassezia, thus forming a vicious circle. Another cause of dandruff is dry scalp. Dry skin or scalp skin barrier is damaged due to frequent washing, scalding, dyeing, etc., so that protease activity responsible for exfoliation of epidermal cells is reduced, and epidermal cells cannot be normally exfoliated, thereby causing dandruff.

Currently, common antidandruff agents in shampoo products are ZPT (zinc pyrithione), OCT (piroctone olamine), ganbazole, and the like. Although ZPT has a good antibacterial effect and has been widely used as an anti-dandruff ingredient for more than 60 years, the european commission revised the european cosmetics regulation annex II ban ingredient list at 11, 2021, in which ZPT was formally effective at 3-1-2022 due to the GHS classification having reproductive toxicity 1B, which also means that the cosmetic anti-dandruff agent ZPT was formally banned in the european cosmetics. At present, ZPT is still listed in a limit raw material catalog and a standard preservative catalog of a cosmetic safety technical specification (2015) edition in China, but the requirements of use concentration/use specification are strict, and the use of ZPT in China is expected to be tightened in the future.

The piroctone olamine salt (P.O.) has the same anti-dandruff effect as ZPT, and has been widely used in daily chemical industry at home and abroad, but is mainly used in middle-high-end washing and caring products due to higher production cost. And its antipruritic effect is poor.

The gamboge has a certain inhibiting effect on the oomycetes or the oopityriasis causing dandruff and the candida albicans and the trichophyton, but the sole use of the gamboge has poor effect of removing dandruff. And it is harmful to aquatic organisms, and can pollute the aquatic environment.

Disclosure of Invention

The embodiment of the application aims to provide a composition for removing dandruff and relieving itching, a preparation method of the composition, shampoo, a preparation method of the shampoo and a medicament.

In a first aspect, the present application provides an anti-dandruff and antipruritic composition comprising, in parts by weight:

0.1-2 parts of polyglycerol-10 laurate;

0.04-0.15 part of dichlorobenzyl alcohol;

0.1-2 parts of sodium salicylate;

0.05-2 parts of allantoin;

0.05-2 parts of sodium lactate C12-13.

According to the anti-dandruff and antipruritic composition, the polyglycerol-10 laurate, dichlorobenzyl alcohol, sodium salicylate, allantoin and sodium lactate C12-13 are mutually compatible, and all the components are synergistic in a synergistic way, so that the anti-dandruff and antipruritic effects are achieved; the anti-dandruff and antipruritic composition provided by the embodiment of the application reduces skin inflammation by inhibiting fungi such as malassezia, and simultaneously repairs skin barriers, nourishes scalp, can improve anti-dandruff and antipruritic effects, reduce irritation to scalp, nourish and moisten gently, and simultaneously has certain conditioning property to hair.

Furthermore, the anti-dandruff and antipruritic composition can be mutually compatible with various components in shampoo, hair-nourishing lotion and other hair-washing products common in the field, and can be used as anti-dandruff and antipruritic active ingredients of the shampoo, the hair-nourishing lotion and other products for preparing the shampoo, the hair-nourishing lotion and other products, has lower cost, is more than half lower than OCT, is more friendly to the environment, can effectively relieve itching while removing dandruff, can reduce the irritation of surfactant in the shampoo to scalp, moisten and moisturize, and has certain conditioning property to hair.

In other embodiments of the present application, the composition comprises, in parts by weight:

0.2-1.9 parts of polyglycerol-10 laurate;

0.05-0.14 part of dichlorobenzyl alcohol;

0.2-1.9 parts of sodium salicylate;

0.1-1.9 parts of allantoin;

0.1-1.9 parts of sodium lactate C12-13.

0.5-2 parts of polyglycerol-10 laurate;

0.1-0.15 part of dichlorobenzyl alcohol;

0.5-2 parts of sodium salicylate;

0.5-2 parts of allantoin;

0.5-2 parts of sodium lactate C12-13.

In a second aspect, the present application provides a shampoo comprising the anti-dandruff, antipruritic composition provided in the first aspect.

In other embodiments of the present application, the shampoo further comprises: sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-7, sodium benzoate, benzyl alcohol, citric acid, essence and water.

In other embodiments of the present application, the shampoo comprises, in mass percent:

0.1% -2% of polyglycerol-10 laurate;

0.04% -0.15% of dichlorobenzyl alcohol;

sodium salicylate 0.1-2%;

allantoin 0.05-2%;

0.05% -2% of sodium lactate C12-13 alcohol;

10% -15% of sodium laureth sulfate;

3% -5% of cocoamidopropyl betaine;

0.5% -5% of polyquaternium-7;

sodium benzoate 0.1-1%;

0.1% -1% of benzyl alcohol;

citric acid 0.1% -3%;

0.1% -0.5% of essence;

the balance being water.

0.1% -2% of polyglycerol-10 laurate;

0.04% -0.15% of dichlorobenzyl alcohol;

sodium salicylate 0.1-2%;

allantoin 0.05-2%;

0.05% -2% of sodium lactate C12-13 alcohol;

10% -13% of sodium laureth sulfate;

3% -4% of cocoamidopropyl betaine;

0.5% -1% of polyquaternium-7;

sodium benzoate 0.1-0.4%;

0.1% -0.3% of benzyl alcohol;

citric acid 0.1% -0.15%;

0.1% -0.4% of essence;

the balance being water.

In a third aspect, the present application provides a method for preparing the anti-dandruff and anti-itch composition, wherein the raw materials of the anti-dandruff and anti-itch composition provided in the first aspect are mixed.

In a fourth aspect, the present application provides a method for preparing a shampoo, including:

uniformly mixing sodium laureth sulfate, cocamidopropyl betaine and water to obtain a first mixture;

adding polyquaternium-7 into the first mixture, and uniformly mixing to obtain a second mixture;

adding polyglycerol-10 laurate, dichlorobenzyl alcohol, sodium salicylate, allantoin and sodium lactate C12-13 alcohol into the second mixture, and uniformly mixing to obtain a third mixture;

and adding sodium benzoate, benzyl alcohol, citric acid and essence into the third mixture, and uniformly mixing.

In a fifth aspect, the present application provides a medicament comprising the anti-dandruff, antipruritic composition provided in the first aspect.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered limiting the scope, and that other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a graph showing the effect of shampoo formulations of examples and comparative examples of the present application on inhibition of malassezia furfur (examples 3 and 4, comparative examples 2 and 7);

FIG. 2 is a graph showing the effect of shampoo formulations of examples and comparative examples of the present application on inhibition of malassezia furfur (examples 5 and 6, comparative examples 3 and 8);

FIG. 3 is a graph of scalp stratum corneum moisture content after application of the shampoo of examples and comparative examples herein (examples 1 and 2, comparative examples 1 and 4);

FIG. 4 is a plot of scalp stratum corneum moisture content after application of the shampoo of examples and comparative examples herein (examples 9 and 10, comparative examples 5 and 10);

FIG. 5 is a plot of scalp stratum corneum moisture content after application of the shampoo of examples and comparative examples herein (examples 7 and 8, comparative examples 4 and 9);

fig. 6 is the results of clinical testing after use of the shampoo of examples and comparative examples of the present application (example 2, comparative examples 1-5, cleansing male anti-dandruff shampoo).

Detailed Description

For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments.

Thus, the following detailed description of the embodiments of the present application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.

The embodiment of the application provides a composition for removing dandruff and relieving itching, which comprises the following components in parts by mass:

0.1-2 parts of polyglycerol-10 laurate;

0.04-0.15 part of dichlorobenzyl alcohol;

0.1-2 parts of sodium salicylate;

0.05-2 parts of allantoin;

0.05-2 parts of sodium lactate C12-13.

According to the anti-dandruff and antipruritic composition provided by the embodiment of the application, the polyglycerol-10 laurate, dichlorobenzyl alcohol, sodium salicylate, allantoin and sodium lactate C12-13 are mutually compatible, and all the components are synergistic in a synergistic way, so that the anti-dandruff and antipruritic effects are generated; the anti-dandruff and antipruritic composition provided by the embodiment of the application reduces skin inflammation by inhibiting fungi such as malassezia, and simultaneously repairs skin barriers, nourishes scalp, can improve anti-dandruff and antipruritic effects, reduce irritation to scalp, nourish and moisten gently, and simultaneously has certain conditioning property to hair.

The anti-dandruff and antipruritic composition can be mutually compatible with various components in hair washing and caring products such as shampoo, shampoo and hair conditioner which are common in the field, and can be used as anti-dandruff and antipruritic active ingredients of products such as shampoo, shampoo and hair conditioner for preparing products such as shampoo, shampoo and hair conditioner.

Further, the anti-dandruff and antipruritic composition provided by the embodiment of the application, wherein the polyglycerol-10 laurate is polymerized by polyglycerol-10 and lauric acid which are natural plant-based, is a mild emulsifier, can gently emulsify scalp grease, reduces the grease secretion of scalp, inhibits excessive reproduction of malassezia, moistens and moisturizes, reduces the degreasing capability of an anionic surfactant, and prevents scalp from falling off due to scalp dryness.

Dichlorobenzyl alcohol has broad-spectrum sterilization, anti-inflammation and itching-relieving effects, and the anti-dandruff itching-relieving composition provided by the embodiment of the application adopts dichlorobenzyl alcohol as an active ingredient and has very good killing property on fungi.

Furthermore, dichlorobenzyl alcohol can also be used in medical products, and has very high safety and stability.

Sodium salicylate is sodium salt of salicylic acid, salicylic acid can be released after hydrolysis, and salicylic acid has strong antifungal and anti-inflammatory effects. According to the anti-dandruff itching-relieving composition provided by the embodiment of the application, the formed dandruff is removed by accelerating the falling of the horny layer through the compound sodium salicylate.

Allantoin, which is also known as: 5-ureidohydantoin, ureidoacetic acid lactam, ureidohydantoin or ureidoimidazole dione is a hydantoin derivative with unique keratin-dissolving properties. The anti-dandruff and antipruritic composition provided by the embodiment of the application can supplement sufficient moisture for the cell gap when the metabolic cutin is peeled off, reduce scalp dryness and hair bifurcation, and also has the functions of anti-sensitization and antipruritic.

Sodium lactate C12-13 is monoester formed by lactic acid and single branched C12/13 primary alcohol isomer, and belongs to the grease of lactic acid carrier. It has good mildness, and linear and low polarity molecules can reduce irritation caused by surfactant. The anti-dandruff and antipruritic composition provided by the embodiment of the application can strengthen the skin barrier function, repair the skin sebum membrane, and provide a very soft skin feel while providing a moisturizing effect.

The anti-dandruff itching-relieving composition provided by the embodiment of the application is compounded with dichlorobenzyl alcohol and sodium salicylate, and the two are synergistic and simultaneously act to enhance the antibacterial effect on malassezia.

Further, the anti-dandruff and antipruritic composition provided by the embodiment of the application has the advantages that the interaction of the polyglycerol-10 laurate, the allantoin and the sodium lactate C12-13 is enhanced, the moisture retention of the scalp is enhanced, the dryness of the scalp is reduced, and the resistance of the scalp to the outside is improved. According to the anti-dandruff itching-relieving composition provided by the embodiment of the application, the anti-dandruff itching-relieving effect of the shampoo is improved by adopting the five raw materials which are compatible according to a certain proportion, the irritation of the surfactant in the shampoo to the scalp can be reduced, the scalp is moistened and moisturized, and meanwhile, the hair is regulated to a certain degree.

Further, in some embodiments of the present application, the anti-dandruff and antipruritic composition comprises, in parts by weight:

0.2-1.9 parts of polyglycerol-10 laurate; 0.05-0.14 part of dichlorobenzyl alcohol; 0.2-1.9 parts of sodium salicylate; 0.1-1.9 parts of allantoin; 0.1-1.9 parts of sodium lactate C12-13.

Further alternatively, in some embodiments of the present application, the anti-dandruff and antipruritic composition described above comprises, in parts by weight:

0.5-2 parts of polyglycerol-10 laurate; 0.1-0.15 part of dichlorobenzyl alcohol; 0.5-2 parts of sodium salicylate; 0.5-2 parts of allantoin; 0.5-2 parts of sodium lactate C12-13.

Illustratively, in some embodiments of the present application, the above-described anti-dandruff antipruritic composition comprises, in parts by weight:

0.5 part, 0.6 part, 0.8 part, 1.0 part, 1.2 parts, 1.5 parts, 1.8 parts and 2 parts of polyglycerol-10 laurate;

0.1 part, 0.11 part, 0.12 part, 0.13 part, 0.14 part or 0.15 part of dichlorobenzyl alcohol;

0.5 part, 0.8 part, 1.0 part, 1.2 parts, 1.5 parts, 1.8 parts or 2 parts of sodium salicylate;

0.5, 0.8, 1, 1.2, 1.5, 1.8 or 2 allantoin;

0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts or 2 parts of sodium lactate C12-13 alcohol.

Some embodiments of the present application provide a method for preparing an anti-dandruff and antipruritic composition, comprising the steps of:

the individual materials of the anti-dandruff and antipruritic composition provided in any of the foregoing embodiments are mixed.

Illustratively, a method of preparing an anti-dandruff, antipruritic composition comprises the steps of: 0.1-2 parts of polyglycerol-10 laurate; 0.04-0.15 part of dichlorobenzyl alcohol; 0.1-2 parts of sodium salicylate; 0.05-2 parts of allantoin; 0.05-2 parts of sodium lactate of C12-13 alcohol are uniformly mixed.

Some embodiments of the present application provide a shampoo comprising the anti-dandruff and antipruritic composition provided in any of the preceding embodiments.

Further, in some embodiments of the present application, the shampoo includes: the shampoo also comprises: sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-7, sodium benzoate, benzyl alcohol, citric acid, essence and water.

Further, in some embodiments of the present application, the shampoo comprises, in mass percent:

0.1% -2% of polyglycerol-10 laurate; 0.04% -0.15% of dichlorobenzyl alcohol; sodium salicylate 0.1-2%; allantoin 0.05-2%; 0.05% -2% of sodium lactate C12-13 alcohol; 10% -15% of sodium laureth sulfate; 3% -5% of cocoamidopropyl betaine; 0.5% -5% of polyquaternium-7; sodium benzoate 0.1-1%; 0.1% -1% of benzyl alcohol; citric acid 0.1% -3%; 0.1% -0.5% of essence; the balance being water.

0.1% -2% of polyglycerol-10 laurate; 0.04% -0.15% of dichlorobenzyl alcohol; sodium salicylate 0.1-2%; allantoin 0.05-2%; 0.05% -2% of sodium lactate C12-13 alcohol; 10% -13% of sodium laureth sulfate; 3% -4% of cocoamidopropyl betaine; 0.5% -1% of polyquaternium-7; sodium benzoate 0.1-0.4%; 0.1% -0.3% of benzyl alcohol; citric acid 0.1% -0.15%; 0.1% -0.4% of essence; the balance being water.

Illustratively, in some embodiments of the present application, the shampoo includes, in mass percent:

0.1%, 0.2%, 0.5%, 1.0%, 1.2%, 1.5%, 1.8% or 2% of polyglycerol-10 laurate;

0.04%, 0.05%, 0.08%, 0.10%, 0.12% or 0.15% dichlorobenzyl alcohol;

sodium salicylate 0.1%, 0.2%, 0.5%, 0.8%, 1.0%, 1.2%, 1.5%, 1.8% or 2%;

allantoin 0.05%, 0.1%, 0.12%, 0.15%, 0.18% or 2%;

0.05%, 0.1%, 0.12%, 0.15%, 0.18% or 2% of sodium lactate C12-13 alcohol;

10%, 11%, 11.5%, 12%, 12.5% or 13% sodium laureth sulfate;

3%, 3.1%, 3.2%, 3.5%, 3.8% or 4% cocoamidopropyl betaine;

0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1% of polyquaternium-7;

sodium benzoate 0.1%, 0.2%, 0.3% or 0.4%;

benzyl alcohol 0.1%, 0.15%, 0.2%, 0.25% or 0.3%;

citric acid 0.1%, 0.11%, 0.12%, 0.13%, 0.14% or 0.15%;

0.1%, 0.2%, 0.3% or 0.4% of essence;

the balance being water.

The shampoo has the beneficial effects that the anti-dandruff and antipruritic composition provided by any embodiment is compounded and used as an active ingredient of the anti-dandruff and antipruritic composition, so that the anti-dandruff and antipruritic effects of the shampoo are improved.

Further, the shampoo can reduce irritation of surfactant to scalp, moisten and moisturize scalp, and also has certain conditioning effect on hair

Some embodiments of the present application provide a method for preparing a shampoo, including:

Further, in some specific embodiments of the present application, the method for preparing the shampoo includes:

step 1, uniformly stirring and mixing sodium laureth sulfate, cocamidopropyl betaine and pure water in an emulsifying pot at room temperature;

step 2, adding polyquaternium-6 into the mixed solution obtained in the step 1, and uniformly stirring and mixing;

step 3, adding polyglycerol-10 laurate, dichlorobenzyl alcohol, sodium salicylate, allantoin and sodium lactate C12-13 into the mixed solution obtained in the step 2, and uniformly stirring and mixing;

and step 4, adding sodium benzoate, benzyl alcohol, citric acid and essence into the mixed solution obtained in the step 3, and uniformly stirring and mixing.

Some embodiments of the present application provide a medicament comprising an anti-dandruff, antipruritic composition provided in any of the preceding embodiments.

Further, in some embodiments of the present application, the dosage forms of the agents described above may be formulated as lotions or as an external liquid formulation.

The features and capabilities of the present application are described in further detail below in connection with the examples:

examples 1 to 10

Providing shampoo, which comprises the following components:

polyglycerol-10 laurate; dichlorobenzyl alcohol; sodium salicylate; allantoin; sodium lactate C12-13; sodium laureth sulfate; cocamidopropyl betaine; polyquaternium-7; sodium benzoate; benzyl alcohol; citric acid; essence and water.

The specific amounts of the individual components of the shampoos provided in each example are shown in Table 1.

The shampoo provided in each example was prepared as follows:

TABLE 1

Comparative example 1-comparative example 10

A shampoo was provided, and the respective component contents of the shampoo provided in each comparative example are shown in table 2; the preparation method is the same as the preparation steps of the shampoo provided in the previous examples.

TABLE 2

The performance of the shampoos provided in the examples and comparative examples is tested in the following.

Test example 1

In vitro anti-dandruff performance test:

and (3) testing the inhibition effect of the shampoo on malassezia furfur by adopting a bacteriostasis ring method, and carrying out a bacteriostasis ring test for evaluating the anti-dandruff effect of each group of anti-dandruff shampoo under the same test condition.

Experimental materials

1. The main instrument is as follows: constant temperature incubator, superclean bench, puncher, pipette, forceps, sterilization flat board.

2. Culture medium: leemming & Notman medium was modified.

3. And (3) strain: malassezia furfur.

4. Test sample: shampoo of example 3, example 4, example 5, example 6 and comparative examples 7, 2, 3, 8.

Experimental details

1. Malassezia furfur is prepared into bacterial suspension with the concentration of about 105 cfu.

2. Uniformly coating on a Leemung & Notman culture medium flat plate, and then placing in a sterile operation table to blow dry the bacterial liquid on the flat plate.

3. And quantitatively adding each group of shampoo samples into the flat plate, culturing in a constant temperature incubator at 30 ℃ for 5-7 days, observing results, and recording and measuring the condition of the inhibition ring.

Experimental results

Recording the results as the diameter of the inhibition ring, unit: millimeter.

Among them, fig. 1 shows the effect of shampoo on inhibition of malassezia furfur, and as can be seen from fig. 1, both comparative example 2 (without dichlorobenzyl alcohol) and comparative example 7 (with 0.02% less dichlorobenzyl alcohol) have unsatisfactory antibacterial effects, and example 3 (0.04% dichlorobenzyl alcohol) has good effect of inhibiting malassezia furfur of dandruff microorganisms. As can be seen from comparison of example 3 and example 4, the effect of inhibiting malassezia furfur is better as the amount of dichlorobenzyl alcohol is increased, but if the amount exceeds 0.15%, the limit of the 2015 cosmetic safety specification is not met, and the cost is too high to have an economic effect.

Sodium salicylate inhibition malassezia synergy test: as shown in fig. 2, the shampoo has a certain antibacterial effect in comparative example 3 (without sodium salicylate) and comparative example 8 (with sodium salicylate being 0.05% lower), but the antibacterial effect is quite different, and the effect of inhibiting the pityromonas versicolor of the dandruff microorganism in example 5 (0.1% sodium salicylate) is obviously enhanced, which means that the sodium salicylate with 0.1% has a better synergistic effect on inhibiting the pityromonas versicolor, the better the synergistic effect on inhibiting the pityromonas versicolor with the increase of the dosage is, the dosage is up to 2% (example 6), the antibacterial effect reaches the highest peak, but the dosage is more than 2%, the sodium salicylate causes a certain stimulation to the scalp, and the cost is too high, so that the shampoo is more suitable for 0.1-2.

Test example 2

Moisture retention performance test:

1. polyglycerol-10 laurate moisture retention test: the tester washes hair with the shampoo of examples and comparative examples at 40 c and dries after washing.

The scalp cuticle moisture content was measured for 0 hours, again for 4 hours in a constant temperature and humidity room, and for 8 hours in a constant temperature and humidity room.

Skin moisture content test probe (instrument software CK-MPA-Multi-Pro be-Ada pterFB) was used: corneometer CM825 measures scalp stratum corneum moisture content. Fig. 3 is a graph of scalp cuticle moisture content (where n=12 indicates the number of test persons and the sample size, and the average result is taken from the data; and the ordinate unit: CU), and as is clear from fig. 3, comparative example 1, in which polyglycerin-10 laurate was not added, has the lowest scalp cuticle moisture content, and next, comparative example 4, in which polyglycerin-10 laurate content is 0.05%, and after the polyglycerin-10 laurate usage amount is more than 0.1% (example 1), the moisturizing effect of the shampoo starts to be greatly improved, and after the polyglycerin-10 laurate usage amount is 2% (example 2), the moisturizing effect is improved to a limited extent. In view of the moisturizing effect and the economical efficiency of the cost, the added amount of 0.1 to 2% of polyglycerol-10 laurate is preferable. In addition, the moisture content of the scalp cuticle after 0h,4h and 8h of comparative example 1, in which no polyglycerol-10 laurate was added, was not greatly different, but the moisture content of the scalp cuticle increased with time after the addition of polyglycerol-10 laurate, indicating that polyglycerol-10 laurate also has a long-lasting moisturizing effect.

2. C12-13 sodium lactate alcohol moisturizing and synergy test; the tester washes hair with 40 ℃ water using the shampoo of the examples and the comparative examples, dries and measures the moisture content of scalp cuticle after washing for 0 hours, measures the moisture content of scalp cuticle again in a constant temperature and humidity room for 4 hours, and measures the moisture content of scalp cuticle again in a constant temperature and humidity room for 8 hours.

Skin moisture content test probe (instrument software CK-MPA-Multi-Pro be-Ada pterFB) was used:

corneometer CM825 measures scalp stratum corneum moisture. Fig. 4 is a graph of scalp cuticle moisture content (where n=12 refers to the number of test persons and the sample size, and the average result of data) and as can be seen from fig. 4, the scalp cuticle of comparative example 5 without added sodium C12-13 lactate and comparative example 10 with added 0.03% has a certain moisture content, but the moisture retention effect of the shampoo after use of the shampoo after added sodium C12-13 lactate (example 9) with 0.05% starts to be improved, and the moisture retention effect is improved greatly after the use amount is 2% (example 10), which indicates that the sodium C12-13 lactate has the effect of enhancing the moisture retention and enhancing effects. However, since the foamability of the shampoo is greatly reduced when the amount of the sodium lactate C12-13 alkoxide added exceeds 2%, the amount of the sodium lactate C12-13 alkoxide added is preferably 0.05 to 2%.

3. Allantoin scalp repair test: the testers weekly, wednesday, friday were evaluated for room moisture content, and shampoo compositions of examples 7, 8 and 4 and 9 were rinsed with 40 ℃ water, dried after rinsing, and measured for moisture content on day 0, day 7, day 14, and scalp stratum corneum.

Skin moisture content test probe (instrument software CK-MPA-Multi-Pro be-Ada pterFB) was used: corneometer CM825 measures scalp stratum corneum moisture. From fig. 5, it is clear that allantoin can increase the moisture content of the scalp stratum corneum, and the moisturizing effect increases with the increase of the amount. The more pronounced the increase in stratum corneum moisture content with increasing trial time (e.g., day 28 data), which suggests that the moisturizing condition of the scalp stratum corneum is improved, especially the increase in allantoin levels is pronounced from 0.05% to 2% (examples 7-8), with more than 2% increasing more slowly.

4. Clinical test of integral anti-dandruff moisturizing performance:

the shampoo of the example 2 and the comparison example 1, the comparison example 2, the comparison example 3, the comparison example 4 and the comparison example 5 and the commercially available active type of the cleaning and man anti-dandruff shampoo are packaged in test packaging bottles of 60 parts to 200mL and sent to test crowd (60 people) for comparison. Each shampoo was used for 4 weeks continuously, and the tester scored the questionnaire test item according to the sense of use. The scoring criteria used 7 points, 1 point being the worst and 7 points being the best, the higher the score the better. The final score is shown in figure 6 (ordinate unit: score) as a statistical average score.

As can be seen from fig. 6, the compositions of the present application were evaluated more highly in each study dimension than the commercial cleaning men's anti-dandruff shampoo sports type.

Further, the composition has synergistic interaction, and the comparison of the comparative example 1 and the example 2 shows that the polyglycerol-10 laurate indirectly increases the efficacy of removing dandruff and inhibiting itch besides obviously increasing moisture; as can be seen by comparing comparative example 2 with example 2, the addition of dichlorobenzyl alcohol enhances the anti-dandruff and antipruritic effects; as can be seen from comparison of comparative example 3 with example 2, sodium salicylate has effects of removing cutin and sterilizing, and further improving capability of removing dandruff and relieving itching; comparison of comparative example 4 with example 2 shows that allantoin has a moisturizing effect, and significantly increases the moisture content of the scalp. Comparison of comparative example 5 with example 2 shows that sodium lactate C12-13 alkoxide has moisturizing and antipruritic effects; 5 substances are synergistic with each other, so that the effects of removing dandruff, relieving itching and preserving moisture are improved.

The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the same, but rather, various modifications and variations may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. An anti-dandruff and antipruritic composition, characterized in that it comprises, in parts by mass:

0.1-2 parts of polyglycerol-10 laurate;

0.04-0.15 part of dichlorobenzyl alcohol;

0.1-2 parts of sodium salicylate;

0.05-2 parts of allantoin;

0.05-2 parts of sodium lactate C12-13.

2. The anti-dandruff and antipruritic composition as claimed in claim 1, wherein said composition comprises, in parts by mass:

0.2-1.9 parts of polyglycerol-10 laurate;

0.05-0.14 part of dichlorobenzyl alcohol;

0.2-1.9 parts of sodium salicylate;

0.1-1.9 parts of allantoin;

0.1-1.9 parts of sodium lactate C12-13.

3. The anti-dandruff and antipruritic composition as claimed in claim 1, wherein said composition comprises, in parts by mass:

0.5-2 parts of polyglycerol-10 laurate;

0.1-0.15 part of dichlorobenzyl alcohol;

0.5-2 parts of sodium salicylate;

0.5-2 parts of allantoin;

0.5-2 parts of sodium lactate C12-13.

4. A shampoo comprising an anti-dandruff, antipruritic composition according to any of claims 1-3.

5. The shampoo of claim 4, wherein the liquid shampoo,

the shampoo further comprises: sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-7, sodium benzoate, benzyl alcohol, citric acid, essence and water.

6. The shampoo of claim 4, wherein the liquid shampoo,

the shampoo comprises the following components in percentage by mass:

0.1% -2% of polyglycerol-10 laurate;

0.04% -0.15% of dichlorobenzyl alcohol;

sodium salicylate 0.1-2%;

allantoin 0.05-2%;

0.05% -2% of sodium lactate C12-13 alcohol;

10% -15% of sodium laureth sulfate;

3% -5% of cocoamidopropyl betaine;

0.5% -5% of polyquaternium-7;

sodium benzoate 0.1-1%;

0.1% -1% of benzyl alcohol;

citric acid 0.1% -3%;

0.1% -0.5% of essence;

the balance being water.

7. The shampoo of claim 4, wherein the liquid shampoo,

the shampoo comprises the following components in percentage by mass:

0.1% -2% of polyglycerol-10 laurate;

0.04% -0.15% of dichlorobenzyl alcohol;

sodium salicylate 0.1-2%;

allantoin 0.05-2%;

0.05% -2% of sodium lactate C12-13 alcohol;

10% -13% of sodium laureth sulfate;

3% -4% of cocoamidopropyl betaine;

0.5% -1% of polyquaternium-7;

sodium benzoate 0.1-0.4%;

0.1% -0.3% of benzyl alcohol;

citric acid 0.1% -0.15%;

0.1% -0.4% of essence;

the balance being water.

8. A process for the preparation of an anti-dandruff antipruritic composition according to any of claims 1 to 3,

mixing the individual raw materials of the anti-dandruff antipruritic composition of any of claims 1-3.

9. The method for preparing a shampoo according to any one of claims 5 to 7, comprising:

uniformly mixing the sodium laureth sulfate, the cocamidopropyl betaine and water to obtain a first mixture;

adding the polyquaternium-7 into the first mixture, and uniformly mixing to obtain a second mixture;

adding the polyglycerol-10 laurate, dichlorobenzyl alcohol, sodium salicylate, allantoin and sodium lactate C12-13 alcohol into the second mixture, and uniformly mixing to obtain a third mixture;

and adding the sodium benzoate, the benzyl alcohol, the citric acid and the essence into the third mixture, and uniformly mixing.

10. A medicament comprising the anti-dandruff antipruritic composition of any of claims 1-3.