CN116034984A - A perfusion system for multiple heart coronary arteries - Google Patents

Abstract

The invention belongs to the technical field of medical devices, and in particular relates to a perfusion system for multiple hearts. A perfusion system for multiple hearts includes a frame, an upper solution tank, a liquid level sensing system, a lifting mechanism, a valve switch, a lower solution tank, an exhaust system, electrical control components, and a liquid circulation system. The invention freely adjusts the height of the upper solution tank through the elevator, and the relative height of the upper and lower solution tanks is adjustable within the range of 1-1.5m, so that the heart is in a full state; the device of the invention has the positive advantages of simple operation and strong practicability.

Description

A perfusion system for multiple heart coronary arteries

technical field

The invention belongs to the technical field of medical devices, and in particular relates to a perfusion system for multiple coronary arteries.

Background technique

At present, the medical devices used in coronary interventional operations need to verify the safety and effectiveness of the devices by means of animal experiments before the clinic. The verification method first simulates the clinical operation method and uses medical devices on experimental animals. Coronary artery interventional surgery, follow-up for a certain period of time according to the established experimental plan to observe the treatment of coronary arteries, and finally through the anatomy of experimental animals, the treated rake vessels and adjacent vascular tissues will be sent for pathological examination to further judge the device Damage to blood vessels.

As we all know, once a living body dies, there will be no fresh blood circulation, and the blood vessels will collapse immediately, and there will be at least a 24-hour time difference from the time the animal is dissected to the time when the specimen is sent to the pathology department for pathological examination, which will greatly affect the accuracy of specimen blood vessel detection. Therefore, it is impossible to judge the real results of animal experiments on medical devices.

A perfusion system for multiple coronary arteries will be able to solve the problem of blood vessel collapse and deterioration in isolated specimens, restore the true tissue of blood vessels in pathological experiments to the greatest extent, and provide reliable test results.

The Chinese patent with the patent application number CN202110540466.0 discloses a device for maintaining the harvested heart to be transplanted. By perfusing the heart, the resected heart can be maintained, waiting to be adopted, but only for one heart to maintain. It can be seen that it is an urgent problem to be solved to provide a mechanical perfusion system that can prevent the collapse and deterioration of the coronary arteries of the isolated heart and keep the heart vessels in a good physiologically active state during long-term storage in vitro.

Contents of the invention

For the defects in the prior art, the object of the present invention is to provide a kind of method that can simultaneously perfuse formalin solution or normal saline to the coronary arteries of animals with a certain body type, such as (pigs, dogs, sheep), etc. Synchronized Cardiac Perfusion Assembly.

The technical solution adopted by the present invention to solve its technical problems is:

A perfusion system for multiple hearts, including a frame, a lower solution tank, a liquid level sensing system, a valve switch, a lifting mechanism, an upper solution tank, and an exhaust system from bottom to top; the electrical control components and the The lifting mechanism is connected to control the up and down movement of the elevator; the lifting mechanism is connected to the upper solution tank and used to control the upper solution tank to move up and down.

Preferably, the perfusion system further includes electrical control components and a liquid circulation system.

Preferably, the electrical control components are connected with the liquid level sensing system for detecting the height of the perfusate in the upper solution tank and the lower solution tank.

Preferably, the electrical control component is connected to the valve switch for controlling the flow of perfusate in the upper solution tank.

Preferably, the electrical control components are connected to the exhaust system for exhausting toxic gases in the box.

Preferably, the electrical control components are connected to the liquid circulation system for powering the perfusate.

Further preferably, the lifting mechanism includes a first power mechanism, a guide rail, a slider and a support; the slider is connected to the guide rail; and the support is connected to the upper solution tank.

Further preferably, the liquid level sensing system includes low liquid level detection and super water level detection.

Further preferably, the exhaust system includes an exhaust duct and a second power mechanism.

Further preferably, the liquid circulation system includes a perfusion fluid filtering device and a perfusion fluid delivery pipeline; the perfusion delivery pipeline includes a delivery conduit and an output conduit, and the upper solution tank is connected to the heart in the lower solution tank through the delivery conduit, so that The lower solution tank is connected with the upper solution tank through an output conduit.

Further preferably, the electrical control components include a timing module, a signal transmission device and a buzzer system.

When the heart is perfused, it takes 12-24 hours for each heart to perfuse each time. The inventor creatively found in the experiment that there may be multiple animals in the experimental animal of a project that need to take heart samples for perfusion, such as the perfusion of a single heart one by one. The time will be very long, which will affect the timeliness of sending pathology. Therefore, perfusing the animal heart samples required for the experiment will save the perfusion time and obtain experimental data that does not affect the pathological judgment.

Compared with prior art, the beneficial effect of the present invention is:

1. The present invention freely adjusts the height of the upper solution tank through the elevator, and the relative height of the upper and lower solution tanks is adjustable within the range of 1-1.5m, so that the coronary arteries of the heart are in a full state.

2. Both the upper and lower solution tanks in the system of the present invention have liquid level sensing systems, and alarms will be issued for low liquid level or excessive water level.

3. 10-20 sample hearts can be placed at the same time for perfusion, without interfering with each other, the heart perfusion can be controlled, and the formalin solution can be successfully perfused into the isolated animal heart.

4. The device of the present invention has the positive advantages of simple operation and strong practicability.

The working principle of a perfusion system for multiple hearts is: before starting the machine, check whether all circuits are normal and whether the water circuit is leaking. Between the level detection water level and the super water level detection, put the heart sample to be tested in the lower solution box, the heart blood inlet is connected to the liquid outlet on the solution box, cover the solution box cover and buckle the lock, and open it on the touch screen Corresponding valve, after the valve is opened, the solution in the upper solution tank will flow into the heart by gravity, and then flow out from the outlet of the heart to the lower solution tank, adjust the height of the upper solution tank by observing the state of the heart, when the upper solution After the tank solution is reduced by a certain amount, the magnetic pump will automatically open, and the solution in the lower solution tank will be pumped into the upper solution tank, and so on.

Description of drawings

Embodiments of the present invention are more fully described with reference to the accompanying drawings. However, the accompanying drawings are for illustration and illustration only, and do not constitute a limitation to the practical scope of the present invention.

FIG. 1 is a schematic diagram of a perfusion system for multiple hearts according to the present invention.

Fig. 2 is a three-dimensional schematic diagram of a perfusion system for multiple hearts according to the present invention.

The serial numbers in the figure are: frame 1, upper solution tank 2, first liquid level sensor 3, lifting mechanism 4, valve switch 5, lower solution tank 6, second liquid level sensor 7, exhaust duct 8, second power mechanism 9, Electrical control components 10, first power mechanism 11, guide rail 12, slider 13, first support 14, second support 15, third support 16, perfusate filter 17, delivery conduit 18, output conduit 19 , an infusion fluid delivery pipeline 20 , a solution circulation pump 21 , and a heart 22 .

Detailed ways

The utility will be further described below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the utility.

Embodiment 1 Composition and connection of a mechanical perfusion system for heart preservation.

In this embodiment, as shown in Figure 1, a cardiac perfusion setup includes a frame 1, an upper solution tank 2, a liquid level sensing system, a lifting mechanism 4, a valve switch 5, a lower solution tank 6, an exhaust system, electrical Control components 10, liquid circulation system; the electrical control components are connected with the lifting mechanism 4 for controlling the up and down movement of the elevator; the lifting mechanism is connected with the upper solution tank for controlling the up and down movement of the upper solution tank; the electrical control components 10 It is connected with the liquid level sensing system for detecting the height of the perfusate in the upper solution tank and the lower solution tank; the electrical control component 10 is connected with the valve switch 5 for controlling the flow of the solution; The electrical control components 10 are connected with the exhaust system to discharge the toxic gas in the box; the electrical control components 10 are connected with the liquid circulation system to provide power for the perfusate; the lifting mechanism 4 includes a first power mechanism 11 , guide rail 12, slider 13 and support member; slider is connected with guide rail; support member is connected with upper solution tank; liquid level sensing system, including low liquid level detection and super water level detection; the exhaust system It includes a suction duct 8 and a second power mechanism 9; the liquid circulation system includes a perfusate filter device 17, a perfusate delivery pipeline 20, and a solution circulation pump 21; the perfusion delivery pipeline 20 includes a delivery conduit 18 and an output conduit 19, and the upper solution tank is transported through The conduit is connected to the heart in the lower solution tank, and the lower solution tank is connected to the upper solution tank through an output conduit; the electrical control component 10 includes a timing module, a signal transmission device and a buzzer system.

Figure 1 provides a schematic diagram of the perfusion system for multiple hearts.

Figure 2 provides a schematic perspective view of the perfusion system for multiple hearts.

The perfusate delivery pipeline includes a plurality of parallel pipelines, including a perfusate delivery pipeline 18 arranged at the end side.

The support includes a first support 14 , a second support 15 and a third support 16 . The liquid level sensing system includes a first liquid level sensor 3 and a second liquid level sensor 7 .

Before starting the machine, check whether the circuit is normal and whether the water circuit is leaking. When ready, pour an appropriate amount of formalin solution into the upper solution tank. The liquid level detection water level is 3cm away from the bottom of the upper solution tank, and the excess water level detection water level is 20cm away from the bottom of the upper solution tank; after pouring, put the heart samples to be tested in the lower solution tank. In this implementation case, the number of heart samples is 15, connect the heart blood inlet to the liquid outlet on the solution tank; after the installation is completed, cover the solution tank cover and buckle the lock, and open the corresponding valve on the touch screen of the electrical control component. After the valve is opened, The solution in the upper solution tank will flow into the heart by gravity, and then flow out from the outlet of the heart into the lower solution tank. The height of the upper solution tank is adjusted through electrical control components to make the heart sample in a full state. In this implementation case, the upper The height of the solution tank is 1.2m; when the solution in the upper solution tank is lower than the low liquid level detection water level, the magnetic pump will automatically open, and the solution in the lower solution tank will be pumped into the upper solution tank, and so on.

Claims (10)

1. A perfusion system for a plurality of immediate isolated coronary arteries, which is characterized by sequentially comprising a frame, a lower solution tank, a liquid level sensing system, a valve switch, a lifting mechanism, an upper solution tank and an exhaust system from bottom to top; the electric control component is connected with the lifting mechanism and used for controlling the lifting mechanism to move up and down; the lifting mechanism is connected with the upper solution tank and used for controlling the upper solution tank to move up and down.

2. The perfusion system for a plurality of cardiac coronary arteries according to claim 1, further comprising an electrical control component, a fluid circulation system.

3. The perfusion system for a plurality of cardiac coronary arteries according to claim 2, wherein the electrical control component is connected to the level sensing system for detecting the level of perfusate in the upper and lower solution tanks; the electric control component is connected with the valve switch and used for controlling the flow of the perfusate in the upper solution tank.

4. The perfusion system for the coronary arteries of the heart of claim 2, wherein the electrical control component is coupled to the exhaust system for exhausting toxic gases from the housing.

5. The perfusion system for a plurality of cardiac coronary arteries according to claim 2, wherein the electrical control component is coupled to the fluid circulation system for powering the perfusate.

6. The perfusion system for a plurality of cardiac coronary arteries according to any one of claims 1 to 5, wherein the lifting mechanism comprises a first power mechanism, a rail, a slider and a support; the sliding block is connected with the guide rail; the supporting piece is connected with the upper solution tank.

7. The perfusion system for a plurality of cardiac coronary arteries according to claim 3, wherein the fluid level sensing system comprises a low fluid level detection and an over-water level detection.

8. The perfusion system for a plurality of cardiac coronary arteries according to claim 4, wherein the exhaust system comprises an exhaust duct and a second power mechanism.

9. The perfusion system for a plurality of cardiac coronary arteries according to claim 5, wherein the fluid circulation system comprises a perfusate filtering device and an perfusate delivery conduit; the perfusion conveying pipeline comprises a conveying conduit and an output conduit, the upper solution tank is connected with the central viscera of the lower solution tank through the conveying conduit, and the lower solution tank is connected with the upper solution tank through the output conduit.

10. The perfusion system for a plurality of cardiac coronary arteries according to claim 2, wherein the electrical control components include a timing module, a signal transmission device, and a buzzer system.

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