CN115969944A - A massage oil with soothing, invigorating and dredging effect - Google Patents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
Description
技术领域technical field
本发明涉及中药油技术领域,更具体地说,它涉及一种具有舒缓活血通络作用的按摩油。The invention relates to the technical field of traditional Chinese medicine oil, more specifically, it relates to a massage oil with the functions of soothing, promoting blood circulation and dredging collaterals.
背景技术Background technique
在生活节奏日益加快和工作压力倍增的现代社会里,不常运动,长期伏案导致人们肩颈部不适,腰背疼痛等亚健康症状,严重地影响着人们的正常生活和工作。当出现上述症状时,采取的治疗方法包括药物治疗、牵引按摩理疗和手术疗法,其中药物治疗副作用明显,且价格昂贵,存在很大的局限性。物理治疗效果不稳定,容易复发。手术治疗对人体造成的损害很大,疗程长且恢复缓慢。In a modern society where the pace of life is accelerating and work pressure is multiplying, infrequent exercise and long-term sitting at desks lead to sub-health symptoms such as shoulder and neck discomfort, low back pain, etc., which seriously affect people's normal life and work. When the above-mentioned symptoms occur, the treatment methods adopted include drug therapy, traction massage physiotherapy and surgical therapy, wherein drug therapy has obvious side effects, is expensive, and has great limitations. The effect of physical therapy is unstable and prone to relapse. Surgical treatment causes great damage to the human body, and the course of treatment is long and recovery is slow.
按摩是以中医的脏腑、经络学说为理论基础,并结合西医的解剖和病理诊断,而用手法作用于人体体表的特定部位以调节机体生理、病理状况,达到理疗目的的方法,从性质上来说,它是一种物理的治疗方法。通过按摩油结合按摩的手法来达到调理各种疾病或者舒缓压力等是目前流行的趋势。Massage is based on the theory of viscera and meridians of traditional Chinese medicine, combined with the anatomy and pathological diagnosis of western medicine, and uses techniques to act on specific parts of the human body surface to adjust the physiological and pathological conditions of the body and achieve the purpose of physical therapy. It is said that it is a physical therapy method. It is currently a popular trend to use massage oil combined with massage techniques to regulate various diseases or relieve stress.
但是目前市面上的按摩油种类繁多,多数以保湿、润滑效果为主,能有效缓解患者病症的按摩油少之又少。But the massage oil on the market is of a great variety at present, and majority is based on moisturizing, lubricating effect, and the massage oil that can effectively alleviate patient's disease is few and far between.
发明内容Contents of the invention
针对现有技术存在的不足,本发明的目的在于提供一种具有舒缓活血通络作用的按摩油,能有效提高经络按摩效果,使经络梗阻、粘连僵硬肌肉快速变软,易于疏通,配合循经按摩技术,缓解甚至消除亚健康症状。In view of the deficiencies in the prior art, the object of the present invention is to provide a massage oil with the effect of relieving blood circulation and dredging collaterals, which can effectively improve the effect of meridian massage, make meridian obstruction, adhesion and stiff muscles quickly soften, easy to dredge, and cooperate with meridians Massage techniques can relieve or even eliminate sub-health symptoms.
本发明的上述目的通过以下方案实现:Above-mentioned purpose of the present invention is achieved through the following scheme:
一种具有舒缓活血通络作用的按摩油,包括以下质量百分比组分:鸡血藤提取物1.2-3.6%、川赤芍根提取物0.8-1.5%、艾叶油0.8-1.5%、羌活提取物0.6-1.2%、姜黄根油0.6-1.2%、肉桂提取物0.1-0.4%、番红花提取物0.05-0.25%、生育酚0.05-0.25%、川芎提取物0.05-0.25%、杜仲提取物0.03-0.12%、人参根提取物0.03-0.12%、透骨草提取物0.03-0.12%、当归提取物0.03-0.12%、天麻根提取物0.03-0.12%、芦荟提取物0.03-0.12%、香精0.01-0.1%、增稠剂0.1-0.3%、pH调节剂0.05-0.15%、防腐剂0.12-0.25%、水余量。A massage oil with the effect of soothing, promoting blood circulation and dredging collaterals, comprising the following components in mass percentage: Caulis Spatholobus extract 1.2-3.6%, Radix Paeoniae Rubra root extract 0.8-1.5%, Artemisia argyi oil 0.8-1.5%, Notopterygium extract 0.6-1.2%, Turmeric Root Oil 0.6-1.2%, Cinnamon Extract 0.1-0.4%, Saffron Extract 0.05-0.25%, Tocopherol 0.05-0.25%, Chuanxiong Extract 0.05-0.25%, Eucommia Extract 0.03 -0.12%, 0.03-0.12% of ginseng root extract, 0.03-0.12% of speranus extract, 0.03-0.12% of angelica extract, 0.03-0.12% of Gastrodia elata root extract, 0.03-0.12% of aloe vera extract, 0.01% of essence -0.1%, thickener 0.1-0.3%, pH regulator 0.05-0.15%, preservative 0.12-0.25%, water balance.
优选地,包括以下质量百分比组分:鸡血藤提取物2.0%、川赤芍根提取物1.15%、艾叶油1.15%、羌活提取物0.8%、姜黄根油0.8%、肉桂提取物0.15%、番红花提取物0.1%、生育酚0.1%、川芎提取物0.1%、杜仲提取物0.05%、人参根提取物0.05%、透骨草提取物0.05%、当归提取物0.05%、天麻根提取物0.05%、芦荟提取物0.05%、香精0.05%、增稠剂0.25%、pH调节剂0.05-0.15%、防腐剂0.15%、水余量。Preferably, the following mass percentage components are included: 2.0% of Caulis Spatholobus extract, 1.15% of Radix Paeoniae Rubra root extract, 1.15% of mugwort leaf oil, 0.8% of notopterygium extract, 0.8% of turmeric root oil, 0.15% of cinnamon extract, Saffron Extract 0.1%, Tocopherol 0.1%, Chuanxiong Extract 0.1%, Eucommia Extract 0.05%, Ginseng Root Extract 0.05%, Sperancus Extract 0.05%, Angelica Extract 0.05%, Gastrodia elata Root Extract 0.05%, aloe extract 0.05%, essence 0.05%, thickener 0.25%, pH regulator 0.05-0.15%, preservative 0.15%, water balance.
优选地,所述增稠剂为卡波姆、黄原胶中的至少一种。Preferably, the thickener is at least one of carbomer and xanthan gum.
优选地,所述pH调节剂为三乙醇胺、柠檬酸、柠檬酸钠中的至少一种。Preferably, the pH regulator is at least one of triethanolamine, citric acid, and sodium citrate.
优选地,所述防腐剂为DMDM乙内酰脲、辛酰羟肟酸中的至少一种。Preferably, the preservative is at least one of DMDM hydantoin and caprylyl hydroxamic acid.
优选地,所述鸡血藤提取物由以下方法制备:将鸡血藤药材粉碎,加入45-55%的乙醇,回流提取2-3次,每次1-2小时,合并提取液,将提取液浓缩至无醇味后用大孔吸附树脂柱进行吸附;然后先用水洗脱至无糖反应,再用65-75%的乙醇洗脱至颜色明显变浅;收集乙醇洗脱液,回收乙醇,蒸干,得到鸡血藤提取物。Preferably, the extract of Spatholobus Spatholobus is prepared by the following method: crush the medicinal materials of Spatholobus Spatholobus, add 45-55% ethanol, reflux extraction for 2-3 times, each time for 1-2 hours, combine the extracts, extract After the liquid is concentrated until it has no alcohol smell, it is adsorbed with a macroporous adsorption resin column; then it is eluted with water until the sugar-free reaction is obtained, and then eluted with 65-75% ethanol until the color is obviously lighter; the ethanol eluate is collected and the ethanol is recovered , and evaporated to dryness to obtain the extract of Spatholobus Spatholobus.
优选地,所述川赤芍根提取物由以下方法制备:对川赤芍根进行筛选和清除杂质,然后放入清水浸泡30mi n,后加入温水中进行充分的煎熬,煎熬时间为2h,先文火,再大火进行煎熬,完成后将煎熬后的液体进行收集。Preferably, the root extract of Radix Paeoniae Rubra Radix is prepared by the following method: screening Radix Radix Radix Radix Radix Radix Paeoniae Alba and removing impurities, then soaking in clear water for 30 min, and then adding warm water to fully decoct. The decoction time is 2 hours. Slow fire, then high fire for torment, and collect the tormented liquid after completion.
原料中各中药成分的药理作用:The pharmacological action of each traditional Chinese medicine component in the raw material:
鸡血藤:具有活血舒筋,养血调经的功效;主治风湿痹痛,手足麻木,肢体瘫痪,月经不调,经行不畅,痛经,经闭,白细胞减少症。Spatholobus Spatholobus: It has the effects of promoting blood circulation and relaxing tendons, nourishing blood and regulating menstruation; it can mainly treat rheumatic arthralgia, numbness of hands and feet, limb paralysis, irregular menstruation, menstrual irregularity, dysmenorrhea, amenorrhea, and leukopenia.
川赤芍:清热凉血,散瘀止痛;与当归、川芎同用,可用于血滞经闭、痛经、症瘕腹痛等症。Chuanzhishao: clearing away heat and cooling blood, dispersing blood stasis and relieving pain; used together with angelica and Chuanxiong, it can be used for amenorrhea due to blood stagnation, dysmenorrhea, abdominal pain and other symptoms.
艾叶油:促进血液循环、增强免疫力、减轻颈椎病、肩周炎等病症,其气味还具有提神醒脑的作用。Mugwort leaf oil: promote blood circulation, enhance immunity, relieve cervical spondylosis, frozen shoulder and other diseases, and its smell also has a refreshing effect.
羌活:性温,祛寒湿,用于外感风寒、头痛无汗、寒湿痹、上肢风湿疼痛。Notopterygium: warm in nature, expelling cold-damp, used for exogenous wind-cold, headache without sweating, cold-damp arthralgia, upper limb rheumatic pain.
姜黄:舒缓关节炎、风湿痛、抽筋、扭伤、肌肉痉挛、尤其是下背部的疼痛;刺激血液循环作用,可减轻心绞痛,还可改善冻疮,血中过高的胆固醇和静脉曲张。Turmeric: relieve arthritis, rheumatic pain, cramps, sprains, muscle spasms, especially lower back pain; stimulate blood circulation, relieve angina, and improve frostbite, high blood cholesterol and varicose veins.
肉桂:温通经脉功能,治外感、风寒、肩臂肢节酸痛,对金黄色葡萄球菌、伤寒杆菌和人型结核杆菌有显著抗菌作用,与姜黄复配能增强人体免疫力,一定程度上起到替代激素或抗生素的效果。Cinnamon: warming and dredging the meridians, curing exogenous diseases, wind-cold, sore shoulders, arms and limbs, has significant antibacterial effect on Staphylococcus aureus, typhoid bacillus and human tuberculosis bacillus, compounded with turmeric can enhance human immunity, to a certain extent to replace the effects of hormones or antibiotics.
番红花:味辛,性温。活血通经,散瘀止痛。用于经闭,痛经,恶露不行,症瘕痞块,胸痹心痛,瘀滞腹痛,胸胁刺痛,跌扑损伤,疮疡肿痛。Saffron: acrid in taste, warm in nature. Promoting blood circulation to stimulate menstrual flow, dissipating blood stasis and relieving pain. Used for amenorrhea, dysmenorrhea, lochia, mass in the abdomen, chest pain and heartache, abdominal pain due to stasis, stabbing pain in the chest and hypochondrium, injury from falls, swelling and pain in sores.
川芎:味辛、性温,活血行气,祛风止痛;用于安抚神经,正头风头痛,症瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。Rhizoma Chuanxiong: pungent in taste, warm in nature, promoting blood circulation and promoting qi, expelling wind and relieving pain; used to appease nerves, rectifying wind and headache, abdominal pain in abdominal mass, tingling pain in chest and hypochondrium, tumbling and swelling pain, headache, rheumatism arthralgia.
杜仲:味甘性温,入肝经和肾经。杜仲主要功能是补肝肾、强筋骨、补精血,同时还能够舒缓安胎。Eucommia ulmoides: sweet in taste and warm in nature, enters liver and kidney meridians. The main function of Eucommia is to nourish the liver and kidney, strengthen the muscles and bones, nourish the essence and blood, and at the same time relieve the fetus.
人参:著名强壮滋补药,适用于调整血压、恢复心脏功能、神经衰弱及身体虚弱等症,也有祛痰、健胃、利尿、兴奋等功效。Ginseng: A well-known strong tonic, suitable for adjusting blood pressure, restoring heart function, neurasthenia, and physical weakness. It also has the effects of eliminating phlegm, strengthening the stomach, diuresis, and excitement.
透骨草:祛风除湿、舒筋活血、散瘀消肿、解毒目痛,主治风湿痹痛、筋骨挛缩、寒湿脚气、腰部扭伤、瘫痪。Speranthum: expelling wind and dampness, relaxing tendons and activating blood circulation, dissipating blood stasis and reducing swelling, detoxifying eye pain, mainly treating rheumatic arthralgia, muscle and bone contracture, cold-damp beriberi, waist sprain, paralysis.
当归:伞形科植物当归的根及根茎,味甘、性辛、温,补血;活血;调经止痛;润燥滑肠。Angelica sinensis: root and rhizome of Umbelliferae Angelica sinensis, sweet in taste, pungent in nature, warm, nourishing blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestines.
天麻:具有息风止痉,平抑肝阳,祛风通络之功效,常用于镇静催眠、抗惊厥、镇痛;还具有调节心血管功能、增强免疫力的作用。Gastrodia elata: It has the effects of dispelling wind and spasm, calming liver yang, dispelling wind and dredging collaterals. It is often used for sedation and hypnosis, anticonvulsions, and analgesia; it also has the effects of regulating cardiovascular function and enhancing immunity.
本申请具有以下有益效果:配方采用活血、行气、舒缓消炎、消肿止疼、伸筋活络、促进血液循坏的中药复配而成,组成简单,效果显著,具有很好的防治各种颈肩腰腿疼痛的功效;筛选合理的生产工艺组合最大限度地提取了鸡血藤的有效成分,提取物中的总黄酮的得率较高,同时减少了杂质溶出。然后依靠植物液的形式给药,可促使药物吸收,迅速起效,缓慢释放,生物利用度高,对各种颈肩腰腿疼痛具有良好的活血通络舒缓效果,且原料成本低。The application has the following beneficial effects: the formula is compounded with traditional Chinese medicines that promote blood circulation, promote qi, relieve inflammation, reduce swelling and relieve pain, stretch tendons and activate collaterals, and promote blood circulation. Efficacy for neck, shoulder, waist, and leg pain; screening and rational production process combination maximizes the extraction of the active ingredients of Miltonia Spatholobus, the yield of total flavonoids in the extract is high, and the dissolution of impurities is reduced. Then it is administered in the form of plant liquid, which can promote the absorption of the drug, take effect quickly, release slowly, have high bioavailability, and have a good effect of promoting blood circulation, dredging collaterals, and soothing various neck, shoulder, waist, and leg pains, and the cost of raw materials is low.
具体实施方式Detailed ways
下面结合实施例对本发明作进一步的描述,但本发明要求保护的范围并不局限于实施例表述的范围。The present invention will be further described below in conjunction with the examples, but the protection scope of the present invention is not limited to the range expressed in the examples.
实施例1Example 1
一种具有舒缓活血通络作用的按摩油,包括以下质量百分比组分:鸡血藤提取物1.2%、川赤芍根提取物0.8%、艾叶油0.8%、羌活提取物0.6%、姜黄根油0.6%、肉桂提取物0.1%、番红花提取物0.05%、生育酚0.05%、川芎提取物0.05%、杜仲提取物0.03%、人参根提取物0.03%、透骨草提取物0.03%、当归提取物0.03%、天麻根提取物0.03%、芦荟提取物0.03%、香精0.01%、增稠剂0.1%、pH调节剂0.05%、防腐剂0.12%、水补足至100%。A massage oil with the effect of soothing, promoting blood circulation and dredging collaterals, comprising the following components in mass percentage: Caulis Spatholobus extract 1.2%, Radix Paeoniae Rubra root extract 0.8%, Artemisia argyi leaf oil 0.8%, Notopterygium extract 0.6%, Turmeric root oil 0.6%, 0.1% cinnamon extract, 0.05% saffron extract, 0.05% tocopherol, 0.05% Chuanxiong extract, 0.03% Eucommia extract, 0.03% ginseng root extract, 0.03% Speranza extract, angelica 0.03% extract, 0.03% Gastrodia elata root extract, 0.03% aloe extract, 0.01% essence, 0.1% thickener, 0.05% pH regulator, 0.12% preservative, and 100% water.
其中,增稠剂由重量为1:1的卡波姆与黄原胶组成;pH调节剂为柠檬酸;防腐剂为辛酰羟肟酸。Wherein, the thickener is composed of carbomer and xanthan gum at a weight ratio of 1:1; the pH regulator is citric acid; and the preservative is octanoyl hydroxamic acid.
上述具有舒缓活血通络作用的按摩油的制备方法如下:The preparation method of the above-mentioned massage oil with soothing, promoting blood circulation and dredging collaterals effect is as follows:
S1:将鸡血藤提取物、川赤芍根提取物、羌活提取物、姜黄根油、肉桂提取物、杜仲提取物、人参根提取物、透骨草提取物0、当归提取物、天麻根提取物、芦荟提取物、增稠剂、一半水加入容器中搅拌,升温至65℃,至各原料完全溶解;S1: Extract of Caulis Spatholobus Spathifolia, Radix Paeoniae Rubra Root Extract, Notopterygium Extract, Turmeric Root Oil, Cinnamon Extract, Eucommia Eucommia Extract, Ginseng Root Extract, Speranthema Extract 0, Angelica Root Extract, Gastrodia elata Root Add the extract, aloe vera extract, thickener, and half of the water into the container and stir, and heat up to 65°C until all raw materials are completely dissolved;
S2:然后降温至50℃,继续向容器中加入剩余的一半水及剩余的各原料,继续搅拌15mi n,降温至35℃以下出料;S2: Then cool down to 50°C, continue to add the remaining half of the water and the remaining raw materials into the container, continue to stir for 15min, cool down to below 35°C and discharge;
S3:最后对料体进行紫外线消毒处理,装入瓶中密封即得。S3: Finally, carry out ultraviolet disinfection treatment on the material body, put it into a bottle and seal it.
上述鸡血藤提取物由以下方法制备:将鸡血藤1公斤粉碎,加入50%乙醇8升回流提取3次,每次2小时,合并提取液,将提取液浓缩至约为药材的1/4重量后用大孔吸附树脂柱进行吸附;然后第一次用水洗脱至无糖反应,第二次用30%乙醇洗脱至颜色明显变浅,第三用65%乙醇洗脱至颜色明显变浅。收集65%乙醇洗脱液,回收乙醇,蒸干,得到鸡血藤提取物52克。The above-mentioned Caulis Spatholobus extract is prepared by the following method: crush 1 kg of Caulis Spatholobus, add 8 liters of 50% ethanol to reflux and extract 3 times, each time for 2 hours, combine the extracts, and concentrate the extracts to about 1/3 of the medicinal materials. After 4 weights, use a macroporous adsorption resin column for adsorption; then elute with water for the first time to sugar-free reaction, elute with 30% ethanol for the second time until the color is obviously lighter, and elute with 65% ethanol for the third time until the color is obvious shallow. The 65% ethanol eluate was collected, the ethanol was recovered, and evaporated to dryness to obtain 52 grams of Spatholobus extract.
上述川赤芍根提取物由以下方法制备:先对干燥的川赤芍根进行筛选和清除杂质,然后粉碎称取1公斤放入清水浸泡30mi n,后加入10升温水中进行充分的煎熬,煎熬时间为2h,先文火,再大火进行煎熬,直至液体体积缩减为原1/4,完成后将煎熬后的液体进行收集。The above-mentioned Radix Paeoniae Rubra root extract is prepared by the following method: first screen the dried Radix Radix Radix Paeoniae Root and remove impurities, then crush and weigh 1 kg, soak it in clear water for 30 minutes, and then add 10 liters of warm water to fully decoct. The time is 2 hours, the fire is first slow, and then the fire is tormented until the volume of the liquid is reduced to 1/4 of the original, and the liquid after the torment is collected after completion.
实施例2Example 2
一种具有舒缓活血通络作用的按摩油,包括以下质量百分比组分:鸡血藤提取物1.2%、川赤芍根提取物0.8%、艾叶油0.8%、羌活提取物0.6%、姜黄根油0.6%、肉桂提取物0.1%、番红花提取物0.05%、生育酚0.05%、川芎提取物0.05%、杜仲提取物0.03%、人参根提取物0.03%、透骨草提取物0.03%、当归提取物0.03%、天麻根提取物0.03%、芦荟提取物0.03%、香精0.01%、增稠剂0.1%、pH调节剂0.05%、防腐剂0.12%、水补足至100%。A massage oil with the effect of soothing, promoting blood circulation and dredging collaterals, comprising the following components in mass percentage: Caulis Spatholobus extract 1.2%, Radix Paeoniae Rubra root extract 0.8%, Artemisia argyi leaf oil 0.8%, Notopterygium extract 0.6%, Turmeric root oil 0.6%, 0.1% cinnamon extract, 0.05% saffron extract, 0.05% tocopherol, 0.05% Chuanxiong extract, 0.03% Eucommia extract, 0.03% ginseng root extract, 0.03% Speranza extract, angelica 0.03% extract, 0.03% Gastrodia elata root extract, 0.03% aloe extract, 0.01% essence, 0.1% thickener, 0.05% pH regulator, 0.12% preservative, and 100% water.
其中,增稠剂由重量为3:2的卡波姆与黄原胶组成;pH调节剂为三乙醇胺;防腐剂为DMDM乙内酰脲。Wherein, the thickener is composed of carbomer and xanthan gum with a weight ratio of 3:2; the pH regulator is triethanolamine; the preservative is DMDM hydantoin.
上述具有舒缓活血通络作用的按摩油的制备方法如下:The preparation method of the above-mentioned massage oil with soothing, promoting blood circulation and dredging collaterals effect is as follows:
S1:将鸡血藤提取物、川赤芍根提取物、羌活提取物、姜黄根油、肉桂提取物、杜仲提取物、人参根提取物、透骨草提取物0、当归提取物、天麻根提取物、芦荟提取物、增稠剂、一半水加入容器中搅拌,升温至65℃,至各原料完全溶解;S1: Extract of Caulis Spatholobus Spathifolia, Radix Paeoniae Rubra Root Extract, Notopterygium Extract, Turmeric Root Oil, Cinnamon Extract, Eucommia Eucommia Extract, Ginseng Root Extract, Speranthema Extract 0, Angelica Root Extract, Gastrodia elata Root Add the extract, aloe vera extract, thickener, and half of the water into the container and stir, and heat up to 65°C until all raw materials are completely dissolved;
S2:然后降温至50℃,继续向容器中加入剩余的一半水及剩余的各原料,继续搅拌15mi n,降温至35℃以下出料;S2: Then cool down to 50°C, continue to add the remaining half of the water and the remaining raw materials into the container, continue to stir for 15min, cool down to below 35°C and discharge;
S3:最后将料体进行紫外线消毒处理,装入瓶中密封即得。S3: Finally, the material body is subjected to ultraviolet disinfection treatment, put into a bottle and sealed.
上述鸡血藤提取物由以下方法制备:将鸡血藤1公斤粉碎,加入50%乙醇8升回流提取3次,每次2小时,合并提取液,将提取液浓缩至约为药材的1/4重量后用大孔吸附树脂柱进行吸附;然后第一次用水洗脱至无糖反应,第二次用30%乙醇洗脱至颜色明显变浅,第三用65%乙醇洗脱至颜色明显变浅。收集65%乙醇洗脱液,回收乙醇,蒸干,得到鸡血藤提取物52克。The above-mentioned Caulis Spatholobus extract is prepared by the following method: crush 1 kg of Caulis Spatholobus, add 8 liters of 50% ethanol to reflux and extract 3 times, each time for 2 hours, combine the extracts, and concentrate the extracts to about 1/3 of the medicinal materials. After 4 weights, use a macroporous adsorption resin column for adsorption; then elute with water for the first time to sugar-free reaction, elute with 30% ethanol for the second time until the color is obviously lighter, and elute with 65% ethanol for the third time until the color is obvious shallow. The 65% ethanol eluate was collected, the ethanol was recovered, and evaporated to dryness to obtain 52 grams of Spatholobus extract.
上述川赤芍根提取物由以下方法制备:先对干燥的川赤芍根进行筛选和清除杂质,然后粉碎称取1公斤放入清水浸泡30mi n,后加入10升温水中进行充分的煎熬,煎熬时间为2h,先文火,再大火进行煎熬,直至液体体积缩减为原1/4,完成后将煎熬后的液体进行收集。The above-mentioned Radix Paeoniae Rubra root extract is prepared by the following method: first screen the dried Radix Radix Radix Paeoniae Root and remove impurities, then crush and weigh 1 kg, soak it in clear water for 30 minutes, and then add 10 liters of warm water to fully decoct. The time is 2 hours, the fire is first slow, and then the fire is tormented until the volume of the liquid is reduced to 1/4 of the original, and the liquid after the torment is collected after completion.
实施例3Example 3
一种具有舒缓活血通络作用的按摩油,包括以下质量百分比组分:鸡血藤提取物3.6%、川赤芍根提取物1.5%、艾叶油1.5%、羌活提取物1.2%、姜黄根油1.2%、肉桂提取物0.4%、番红花提取物0.25%、生育酚0.25%、川芎提取物0.25%、杜仲提取物0.12%、人参根提取物0.12%、透骨草提取物0.12%、当归提取物0.12%、天麻根提取物0.12%、芦荟提取物0.12%、香精0.05%、增稠剂0.15%、pH调节剂0.08%、防腐剂0.15%、水补足至100%。A massage oil with the effect of soothing, promoting blood circulation and dredging collaterals, comprising the following components in mass percentage: Caulis Spatholobus extract 3.6%, Radix Paeoniae Rubra root extract 1.5%, Artemisia argyi leaf oil 1.5%, Notopterygium extract 1.2%, Turmeric root oil 1.2%, 0.4% cinnamon extract, 0.25% saffron extract, 0.25% tocopherol, 0.25% Chuanxiong extract, 0.12% Eucommia extract, 0.12% ginseng root extract, 0.12% Speranza extract, Angelica 0.12% extract, 0.12% Gastrodia elata root extract, 0.12% aloe extract, 0.05% essence, 0.15% thickener, 0.08% pH regulator, 0.15% preservative, and 100% water.
其中,增稠剂由重量为3:2的卡波姆与黄原胶组成;pH调节剂为柠檬酸钠;防腐剂由重量为1:1的DMDM乙内酰脲与辛酰羟肟酸组成。Among them, the thickener is composed of carbomer and xanthan gum with a weight of 3:2; the pH regulator is sodium citrate; the preservative is composed of DMDM hydantoin and caprylyl hydroxamic acid with a weight of 1:1 .
上述具有舒缓活血通络作用的按摩油的制备方法如下:The preparation method of the above-mentioned massage oil with soothing, promoting blood circulation and dredging collaterals effect is as follows:
S1:将鸡血藤提取物、川赤芍根提取物、羌活提取物、姜黄根油、肉桂提取物、杜仲提取物、人参根提取物、透骨草提取物0、当归提取物、天麻根提取物、芦荟提取物、增稠剂、一半水加入容器中搅拌,升温至65℃,至各原料完全溶解;S1: Extract of Caulis Spatholobus Spathifolia, Radix Paeoniae Rubra Root Extract, Notopterygium Extract, Turmeric Root Oil, Cinnamon Extract, Eucommia Eucommia Extract, Ginseng Root Extract, Speranthema Extract 0, Angelica Root Extract, Gastrodia elata Root Add the extract, aloe vera extract, thickener, and half of the water into the container and stir, and heat up to 65°C until all raw materials are completely dissolved;
S2:然后降温至50℃,继续向容器中加入剩余的一半水及剩余的各原料,继续搅拌15mi n,降温至35℃以下出料;S2: Then cool down to 50°C, continue to add the remaining half of the water and the remaining raw materials into the container, continue to stir for 15min, cool down to below 35°C and discharge;
S3:最后将料体进行紫外线消毒处理,装入瓶中密封即得。S3: Finally, the material body is subjected to ultraviolet disinfection treatment, put into a bottle and sealed.
上述鸡血藤提取物由以下方法制备:将鸡血藤1公斤粉碎,加入50%乙醇8升回流提取3次,每次2小时,合并提取液,将提取液浓缩至约为药材的1/4重量后用大孔吸附树脂柱进行吸附;然后第一次用水洗脱至无糖反应,第二次用30%乙醇洗脱至颜色明显变浅,第三用65%乙醇洗脱至颜色明显变浅。收集65%乙醇洗脱液,回收乙醇,蒸干,得到鸡血藤提取物52克。The above-mentioned Caulis Spatholobus extract is prepared by the following method: crush 1 kg of Caulis Spatholobus, add 8 liters of 50% ethanol to reflux and extract 3 times, each time for 2 hours, combine the extracts, and concentrate the extracts to about 1/3 of the medicinal materials. After 4 weights, use a macroporous adsorption resin column for adsorption; then elute with water for the first time to sugar-free reaction, elute with 30% ethanol for the second time until the color is obviously lighter, and elute with 65% ethanol for the third time until the color is obvious shallow. The 65% ethanol eluate was collected, the ethanol was recovered, and evaporated to dryness to obtain 52 grams of Spatholobus extract.
上述川赤芍根提取物由以下方法制备:先对干燥的川赤芍根进行筛选和清除杂质,然后粉碎称取1公斤放入清水浸泡30mi n,后加入10升温水中进行充分的煎熬,煎熬时间为2h,先文火,再大火进行煎熬,直至液体体积缩减为原1/4,完成后将煎熬后的液体进行收集。The above-mentioned Radix Paeoniae Rubra root extract is prepared by the following method: first screen the dried Radix Radix Radix Paeoniae Root and remove impurities, then crush and weigh 1 kg, soak it in clear water for 30 minutes, and then add 10 liters of warm water to fully decoct. The time is 2 hours, the fire is first slow, and then the fire is tormented until the volume of the liquid is reduced to 1/4 of the original, and the liquid after the torment is collected after completion.
对比例1Comparative example 1
原料中不含有当归提取物,其它原料组成及制备方法与实施例2相同。The raw material does not contain angelica extract, and the composition and preparation method of other raw materials are the same as in Example 2.
对比例2Comparative example 2
原料中不含有肉桂提取物,其它原料组成及制备方法与实施例2相同。The raw materials do not contain cinnamon extract, and the composition and preparation method of other raw materials are the same as in Example 2.
对比例3Comparative example 3
原料中不含有当归提取物和肉桂提取物,其它原料组成及制备方法与实施例2相同。The raw materials do not contain angelica extract and cinnamon extract, and the composition and preparation method of other raw materials are the same as in Example 2.
对比例4Comparative example 4
原料中不含有姜黄根油,其它原料组成及制备方法与实施例2相同。The raw materials do not contain turmeric root oil, and the composition and preparation method of other raw materials are the same as in Example 2.
测试项目:Test items:
(1)刺激性测试:将实施例1-3及对比例1-4制备得到的具有舒缓活血通络作用的按摩油做斑点贴敷实验,分别取等量样品对同一人肩部及背部肌肤进行单次和多次给药,并进行30分钟,1小时,4小时,8小时,12小时,24小时观察,按表1的标准进行评分,结果显示均为阴性反应。(1) Irritation test: The massage oil prepared in Examples 1-3 and Comparative Examples 1-4 with the effect of soothing, promoting blood circulation and dredging collaterals was used for spot application experiments, and equal samples were taken respectively to apply to the shoulder and back skin of the same person. Perform single and multiple administrations, and observe for 30 minutes, 1 hour, 4 hours, 8 hours, 12 hours, and 24 hours, and score according to the standards in Table 1, and the results show that they are all negative reactions.
表1Table 1
(2)透皮力度:以Franze扩散池法考察实施例1-3及对比例1-4中按摩油的促透效果,得到表2数据。具体步骤为:1)将制备好的鼠皮用铁夹子固定在透皮吸收仪的两室扩散池之间,向垂直扩散池的接受池内加入5mL质量分数为0.9%的生理盐水,控制接受池的搅拌速度为400r/mi n,恒温槽中水温为37±0.1℃。2)向供给池内加入供给液,以保鲜膜封住上口。当样品渗透10mi n、30mi n、1h、1.5h和2h时,分别对接受液进行取样V2,置于离心管中。每次取样的同时向接受池中补充等量的接受液并排除池中的气泡。3)通过HPLC检测样品中总黄酮(主要来自于鸡血藤提取物)的浓度,计算累积透过量Q,计算公式如下:(2) Transdermal strength: The penetration-promoting effect of the massage oil in Examples 1-3 and Comparative Examples 1-4 was investigated by the Franze diffusion cell method, and the data in Table 2 were obtained. The specific steps are: 1) Fix the prepared mouse skin between the two-chamber diffusion cells of the transdermal absorption instrument with iron clips, add 5 mL of normal saline with a mass fraction of 0.9% in the receiving cell of the vertical diffusion cell, and control the concentration of the receiving cell. The stirring speed is 400r/min, and the water temperature in the constant temperature bath is 37±0.1°C. 2) Add the supply liquid into the supply tank, and seal the upper opening with plastic wrap. When the sample is infiltrated for 10min, 30min, 1h, 1.5h and 2h, the receiving solution is sampled V 2 and placed in a centrifuge tube. At the same time of each sampling, add an equal amount of receiving liquid to the receiving pool and remove the air bubbles in the pool. 3) Detect the concentration of total flavonoids (mainly from the extract of Spatholobus Spatholobus) in the sample by HPLC, and calculate the cumulative permeation Q, the calculation formula is as follows:
其中,Q为累积透过量(10-4mg/cm2),S为透皮扩散面积(cm2),V1为Franze扩散池接受液体积(V1=5mL),ρn为第n次取样时接受液的质量浓度(mg/mL),ρi为第i次取样时接受液的质量浓度(mg/mL),V2为取样量(mL)。Among them, Q is the cumulative permeation amount (10 -4 mg/cm 2 ), S is the transdermal diffusion area (cm 2 ), V1 is the receiving fluid volume of the Franze diffusion cell (V 1 =5mL), and ρ n is the nth sampling ρi is the mass concentration of the receiving solution (mg/mL) at the time of sampling i, and V2 is the sampling volume (mL).
表2Table 2
从表2可以看出,本发明的按摩油奇效时间短,10mi n就能产生促透效果,当归提取物和肉桂提取物对其促透效果起着重要作用,具体为当归提取物的促透效果优于肉桂提取物的促透效果,两者合用效果更佳。As can be seen from Table 2, the massage oil of the present invention has a short miraculous effect time and can produce a penetration-promoting effect within 10 min. Angelica extract and cinnamon extract play an important role in its penetration-promoting effect, specifically the penetration-promoting effect of Angelica extract. The effect is better than the penetration-promoting effect of cinnamon extract, and the combined effect of the two is better.
(3)临床验证:对40例年龄在25-70周岁的患者进行试用验证,其中以肩关节疼痛为主诉的患者10例,髋关节疼痛为主诉的患者10例,腰椎关节疼痛主诉的患者10例,四肢疼痛为主诉的患者10例。40例患者每天将实施例2得到的按摩油涂抹于患处,早中晚各一次,一个月为1个疗程,服用3个疗程后确认疗效。(3) Clinical verification: 40 patients aged 25-70 were tested for trial verification, including 10 patients with shoulder joint pain as the main complaint, 10 patients with hip joint pain as the main complaint, and 10 patients with lumbar joint pain as the main complaint. For example, 10 patients complained of limb pain. 40 routine patients applied the massage oil obtained in Example 2 to the affected part every day, once in the morning, at noon and in the evening, one month was a course of treatment, and the curative effect was confirmed after taking 3 courses of treatment.
疗效评价标准如下:The efficacy evaluation criteria are as follows:
治愈:临床症状体征消失,1年内未复发。Cure: the clinical symptoms and signs disappeared, and there was no recurrence within 1 year.
显效:主要症状体征消失。Markedly effective: the main symptoms and signs disappear.
有效:主要症状体征明显好转。Effective: The main symptoms and signs were significantly improved.
无效:与治疗前相比症状体征无改善。Ineffective: No improvement in symptoms and signs compared with before treatment.
治疗数据如下:The treatment data are as follows:
治愈:共11例,其中,肩关节疼痛患者4例、髋关节疼痛患者2例、腰椎关节疼痛患者3例、四肢疼痛2例。Cured: 11 cases in total, including 4 cases of shoulder joint pain, 2 cases of hip joint pain, 3 cases of lumbar joint pain, and 2 cases of limb pain.
显效:共22例,其中,肩关节疼痛患者5例、髋关节疼痛患者6例、腰椎关节疼痛患者4例、四肢疼痛7例。Significantly effective: 22 cases in total, including 5 cases of shoulder joint pain, 6 cases of hip joint pain, 4 cases of lumbar joint pain, and 7 cases of limb pain.
有效:共7例,其中,肩关节疼痛患者1例、髋关节疼痛患者2例、腰椎关节疼痛患者3例、四肢疼痛1例。Effective: 7 cases in total, including 1 case of shoulder joint pain, 2 cases of hip joint pain, 3 cases of lumbar joint pain, and 1 case of limb pain.
无效:共0例。Invalid: 0 cases in total.
以上具有舒缓活血通络作用的按摩油的治愈率为27.5%,显效率为55%,有效率为17.5%,总有效率为100%。由此说明本发明的具有舒缓活血通络作用的按摩油能使经络梗阻、粘连僵硬肌肉快速变软,易于疏通,配合循经按摩技术,缓解甚至消除亚健康症状,可用于治疗风湿关节炎、肩周炎、颈椎病、腰椎病等疾病。The above massage oils with soothing, promoting blood circulation and dredging collaterals have a healing rate of 27.5%, an effective rate of 55%, an effective rate of 17.5%, and a total effective rate of 100%. This shows that the massage oil of the present invention with the effect of relieving blood circulation and dredging collaterals can make meridian obstruction and adhesions and stiff muscles soften quickly and be easy to dredge, and cooperate with meridian massage technology to relieve or even eliminate sub-health symptoms, and can be used to treat rheumatoid arthritis, Frozen shoulder, cervical spondylosis, lumbar spondylosis and other diseases.
以上所述仅是本发明的优选实施方式,本发明的保护范围并不仅局限于上述实施例,凡属于本发明思路下的技术方案均属于本发明的保护范围。应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理前提下的若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。The above descriptions are only preferred implementations of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions under the idea of the present invention belong to the protection scope of the present invention. It should be pointed out that for those skilled in the art, some improvements and modifications without departing from the principles of the present invention should also be regarded as the protection scope of the present invention.
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