CN115868662B - A novel nicotine salt and its preparation method, and atomizing liquid - Google Patents
A novel nicotine salt and its preparation method, and atomizing liquid Download PDFInfo
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- CN115868662B CN115868662B CN202211668618.6A CN202211668618A CN115868662B CN 115868662 B CN115868662 B CN 115868662B CN 202211668618 A CN202211668618 A CN 202211668618A CN 115868662 B CN115868662 B CN 115868662B
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 69
- 239000007788 liquid Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 230000002378 acidificating effect Effects 0.000 claims abstract description 32
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 30
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229960002715 nicotine Drugs 0.000 claims abstract description 26
- 238000002156 mixing Methods 0.000 claims abstract description 22
- 150000007524 organic acids Chemical class 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 12
- 238000005868 electrolysis reaction Methods 0.000 claims description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003792 electrolyte Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 3
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims description 3
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 3
- 229930016911 cinnamic acid Natural products 0.000 claims description 3
- 235000013985 cinnamic acid Nutrition 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 229940040102 levulinic acid Drugs 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229960003512 nicotinic acid Drugs 0.000 claims description 3
- 235000001968 nicotinic acid Nutrition 0.000 claims description 3
- 239000011664 nicotinic acid Substances 0.000 claims description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- YQUVCSBJEUQKSH-UHFFFAOYSA-N protochatechuic acid Natural products OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 claims description 3
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 claims description 3
- 235000019640 taste Nutrition 0.000 abstract description 11
- 230000007794 irritation Effects 0.000 abstract description 10
- 238000010669 acid-base reaction Methods 0.000 abstract description 3
- 230000009965 odorless effect Effects 0.000 abstract description 3
- 238000005086 pumping Methods 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 9
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 230000001953 sensory effect Effects 0.000 description 8
- 235000002906 tartaric acid Nutrition 0.000 description 8
- 239000011975 tartaric acid Substances 0.000 description 8
- 210000003128 head Anatomy 0.000 description 7
- 239000013078 crystal Substances 0.000 description 6
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical compound CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- QLDPCHZQQIASHX-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.CN1CCCC1C1=CC=CN=C1 QLDPCHZQQIASHX-UHFFFAOYSA-N 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 231100000344 non-irritating Toxicity 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 229960000448 lactic acid Drugs 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010007269 Carcinogenicity Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- GJHLWNOWQBUDJX-UHFFFAOYSA-N benzoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OC(=O)C1=CC=CC=C1 GJHLWNOWQBUDJX-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000007670 carcinogenicity Effects 0.000 description 1
- 231100000260 carcinogenicity Toxicity 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003571 electronic cigarette Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- -1 nicotine salts Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the field of electronic atomized liquid, in particular to novel nicotine salt, a preparation method thereof and an atomized liquid, wherein the novel nicotine salt is prepared by mixing and reacting 5-20 parts of acidic electrolyzed water, 1-10 parts of organic acid, 10-30 parts of nicotine and 40-80 parts of glycerol according to mass percent, and the preparation method comprises the steps of (A) adding the acidic electrolyzed water and the organic acid into the nicotine for mixing and stirring, and (B) adding a glycerol magnetic stirrer for mixing and reacting. Sequentially adding the novel nicotine salt into propylene glycol and glycerol, mixing and stirring to obtain an atomized liquid. Because the acidic electrolyzed water is colorless and odorless, has acidic characteristics and enriches H+, and uses the acidic electrolyzed water to replace or partially replace organic acid to generate nicotine salt, the acidic electrolyzed water is safer and has no peculiar smell and irritation caused by the traditional organic acid, the pumping experience is better and more comfortable, and the water is used for directly carrying out acid-base reaction to generate nicotine salt, so that fog is more moist, more flexible and better in taste.
Description
Technical Field
The invention relates to the field of electronic atomization, in particular to novel nicotine salt, a preparation method thereof and atomized liquid.
Background
The electronic atomizing device atomizes the atomized liquid by means of heating, atomizing and the like, so as to achieve the aim of nicotine intake by a human body. The electronic atomization device has the characteristics of zero tar, no suspended solid particles, no carbon monoxide and the like. The traditional atomized liquid solvent mainly comprises propylene glycol and glycerin, the taste reduction degree is good in the sucking process, the irritation is small, but on one hand, due to the fact that the glycerin has a relatively high boiling point and is easy to absorb moisture, aerosol generated in the atomizing process is not easy to condense in the air, a plurality of tiny liquid drops can be condensed to be suspended in the air, obvious mist can be generated when consumers use the atomized liquid solvent, and the appearance of a city is affected in public places, and on the other hand, substances such as nicotine or nicotine salt are contained in the mist, and certain trouble is caused to the public.
The nicotine reacts with acid to form nicotine salt, which can relieve throat feeling and discomfort caused by high concentration nicotine.
Chinese patent application CN 113880802a discloses a tartaric acid-nicotine salt, its preparation method and application, and preparation method of anhydrous tartaric acid crystal. The preparation method of the tartaric acid-nicotine salt comprises the following steps of mixing and stirring anhydrous tartaric acid crystals and propylene glycol to prepare an anhydrous tartaric acid solution, and mixing nicotine and the anhydrous tartaric acid solution. The raw materials of the tartaric acid-nicotine salt are anhydrous tartaric acid crystals, propylene glycol and nicotine, and the solubility, melting point, dissolution rate, biological effectiveness and the like of the anhydrous tartaric acid crystals are different from those of tartaric acid with crystal water in the market, so that carboxyl groups of the anhydrous tartaric acid crystals are more prone to neutralization reaction with alkaline groups to generate salt, and thus, pungency or throat feeling brought by nicotine to a user can be eliminated.
Chinese patent application CN 114343229A discloses a method for preparing novel nicotine salt. The preparation method comprises the following steps of S1, adding organic acid into a solvent, heating and dissolving, S2, adding nicotine, heating and stirring to obtain nicotine salt, wherein the organic acid is one of benzoic acid, dihydroxybenzoic acid, vanillic acid, cinnamic acid, nicotinic acid, salicylic acid, sorbic acid, levulinic acid and lactic acid. The invention also takes mixed acid as raw material, adopts a stepwise feeding mode, so that the prepared nicotine salt has unique flavor, the electronic atomized liquid is more similar to the taste of the traditional cigarette, and the auxiliary acid is added to enable the nicotine salt to form a gel structure, thereby improving the stability and being convenient for storage.
Chinese patent application CN 115251451a discloses an electronic atomized liquid and its preparation method. The electronic atomized liquid comprises 20-50 parts of dimethyl sulfoxide, 30-100 parts of 3-methyl-2-butanol, 5-20 parts of water, 0.5-6 parts of nicotine and 0.4-7.5 parts of organic acid, and the method comprises the steps of mixing the nicotine and the organic acid, adding 40-50% of dimethyl sulfoxide, 3-methyl-2-butanol and water, heating and stirring uniformly, cooling to room temperature, standing to obtain nicotine salt, adding the rest components, and stirring uniformly at room temperature to obtain the electronic atomized liquid. The electronic atomized liquid can be used for obtaining similar effects of smoke quantity, taste and the like, but has more harmless components, is not easy to generate micromolecular carbonyl compounds, and greatly reduces the carcinogenicity of the electronic atomized liquid.
However, the existing nicotine salt preparation method has the problems of unreasonable raw material selection, strong organic acid odor, insufficient softness, influence on the taste of atomized liquid and the like.
Disclosure of Invention
In order to overcome the defects that organic acid reacts with nicotine to generate nicotine salt in the prior art, the safety is lower, the cost is higher, the taste can be adversely affected by an external chemical reagent, the smoke has peculiar smell, the suction experience is poor, and the taste is poor. The invention provides novel nicotine salt, a preparation method thereof and atomized liquid.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows:
A novel nicotine salt is prepared from acidic electrolyzed water, organic acid, glycerol and nicotine by mixing and reacting.
Preferably, the acidic electrolyzed water is 5-20 parts, the organic acid is 1-10 parts, the nicotine is 10-30 parts and the glycerol is 40-80 parts by mass percent.
Preferably, the acidic electrolyzed water is obtained by adopting a salt electrolyte, regulating the electrolysis time, electrolyzing by an electrolyzed water generator, and enriching H+ to an anode membrane for filtration.
Preferably, the salt electrolyte is food grade potassium carbonate.
Preferably, the pH value of the acidic electrolyzed water is 2-5.
Preferably, the organic acid is one or more of benzoic acid, lactic acid, dihydroxybenzoic acid, vanillic acid, cinnamic acid, nicotinic acid, salicylic acid, sorbic acid and levulinic acid.
A preparation method of novel nicotine salt comprises the following steps:
(A) Adding acidic electrolyzed water and organic acid into nicotine, mixing and stirring;
(B) And adding glycerol for mixing reaction.
Preferably, the step (B) is carried out by mixing and reacting for 3-4h by using a magnetic stirrer.
An atomized liquid is prepared from new nicotine salt by sequentially adding propylene glycol and glycerol, mixing and stirring.
Preferably, the nicotine salt is 10-20 parts by mass, propylene glycol is 50-60 parts by mass and glycerol is 30-40 parts by mass.
The acidic electrolyzed water is acidic water with pH of 2-5, which is prepared by adding salt electrolyte (potassium carbonate) solution through electrolysis, regulating electrolysis time and electrolysis pressure, and enriching H+ into an anode, has the acidic characteristics and the enriched H+ and can react with nicotine to generate nicotine salt, meanwhile, the water is colorless and odorless, does not bring bad taste to atomized liquid, and the atomized liquid prepared by taking the nicotine salt as a raw material is more flexible in suction, moist and better in taste, the acidic electrolyzed water can be used for replacing or partially replacing the effect of organic acid to react with nicotine to generate the nicotine salt, and the atomized liquid prepared by the acidic electrolyzed water has better taste and no peculiar smell.
Detailed Description
Specific examples of the present invention will be described below in terms of the composition of raw materials, the proportions, specific preparation steps, test results, and the like.
Introduction of raw materials
1. The novel nicotine salt comprises raw material components and the proportion (in percentage by mass) of each component
Table 1 nicotine salt formulation
| Examples | Nicotine | Acidic electrolyzed water | Benzoic acid | Glycerol |
| 1 | 20 | 17 | 2 | 60 |
| 2 | 20 | 15 | 5 | 60 |
| 3 | 20 | 12 | 8 | 60 |
| 4 | 20 | 10 | 10 | 60 |
| CK | 20 | 0 | 20 | 60 |
Wherein CK refers to a control, i.e., no acidic electrolyzed water was added during the mixing reaction.
2. The preparation method comprises the following steps
(1) Preparing acidic electrolyzed water by adopting food-grade potassium carbonate, regulating the electrolysis time, electrolyzing by an electrolyzed water generator, and filtering H+ enriched to an anode membrane to obtain acidic electrolyzed water with pH value of 2-5;
(2) Adding 5-20 parts of acidic electrolyzed water and 1-10 parts of benzoic acid into 10-30 parts of nicotine, mixing and stirring, and adding 40-80 parts of glycerol and a magnetic stirrer for mixing and reacting for 3-4h;
(3) Mixing 10-20 parts of nicotine salt prepared by the method with 50-60 parts of propylene glycol;
(4) Adding 30-40 parts of glycerol into the liquid obtained in the step (3), and uniformly mixing and stirring to obtain an atomized liquid.
3. Sensory evaluation
The manner of sensory evaluation and scores are described as follows:
Appearance, namely, the visual state of the atomized liquid when the atomized liquid is kept stand at room temperature, wherein the uniform and transparent state is 5 minutes, and the atomized liquid has turbidity or is layered to be 0 minutes;
irritation, namely irritation to throat and nasal cavity mainly, no irritation for 5-4 minutes, slight irritation for 4-3 minutes, moderate irritation for 3-2 minutes, and obvious irritation for 2-1 minute;
the visible degree of fog refers to the degree of visible fog generated by atomized liquid during large circulation suction or lung suction, the visible fog is 5-4 minutes, the slight fog is 4-3 minutes, the light fog is 3-2 minutes, and the obvious fog is 2-1 minute;
The operation of the sensory evaluation is described as follows:
15 parts of the nicotine salts prepared in examples 1-4 and CK are respectively mixed and stirred uniformly with 60 parts of propylene glycol, 30 parts of glycerol are respectively added, mixed and stirred uniformly to obtain 5 atomized liquids, 30 persons (men: women=3:1) of the suction technicians carry out sensory evaluation on the 5 atomized liquids by using an atomizer, and sensory evaluation is given by adopting a anonymous scoring mode. Wherein, each evaluation and suction technician adopts a lung suction method to suck 10 mouths of each atomized liquid, each mouth is separated by 10 seconds, and the interval time of sucking different atomized liquids is not less than 20 minutes, so as to avoid mutual influence. Sensory evaluation items include 5 items of throat feel, irritation, softness, miscellaneous/aftertaste, and top feel, and the comparison results are shown in table 2 below.
TABLE 2 sensory evaluation results of nicotine salts
| Examples | Sensory evaluation results |
| 1 | The throat feeling is strong, the throat feeling is non-irritating, the throat feeling is very soft and smooth, no peculiar smell is generated, the throat feeling is more moist, and the head feeling is strong. |
| 2 | The throat feeling is strong, the throat feeling is non-irritating, the throat feeling is very soft and smooth, no peculiar smell is generated, the throat feeling is more moist, and the head feeling is strong. |
| 3 | The throat feeling is strong, the throat feeling is non-irritating, the throat feeling is very soft, the throat feeling is smooth and moist, and the head feeling is strong. |
| 4 | Has strong throat feeling, no irritation, more compliance, no peculiar smell and strong head feeling. |
| CK | The throat feeling is weaker, the throat feeling is slightly irritative, the throat feeling is softer, the throat feeling is slightly peculiar smell, and the head feeling is slightly weaker. |
Wherein, 20 persons who evaluate and inhale all select the atomized liquid prepared by using the nicotine salt prepared by using the electrolyzed water in the embodiment 1-4 to inhale better, the throat feeling is strong, the head feeling is strong, the fog is fine and moist, no peculiar smell is generated, and the throat feeling means that the throat has itching or uncomfortable feeling after inhaling the electronic cigarette oil smoke.
From the test results, 1, the nicotine salt prepared by adding the acidic electrolyzed water has stronger feeling of head, 2, the nicotine salt fog prepared by using the acidic electrolyzed water is more flexible and moist, and 3, the nicotine salt fog prepared by using the acidic electrolyzed water has no peculiar smell, is finer and has long fragrance.
The invention discloses a novel nicotine salt preparation method, which uses acid electrolyzed water for acid-base reaction, wherein the acid electrolyzed water is acid water with pH reaching 2-5, which is prepared by adding salt electrolyte (potassium carbonate) solution through electrolysis, regulating electrolysis time and electrolysis pressure, and is enriched to an anode, the acid property and the enriched H+ have the condition that the acid-base reaction can be carried out with nicotine to generate nicotine salt, meanwhile, the water is colorless and odorless, no bad taste is brought to an atomized liquid, and the addition of the water ensures that the atomized liquid prepared by taking the nicotine salt as a raw material is more flexible in suction and wet, has better taste, and the acid electrolyzed water can be used for replacing or partially replacing the effect of organic acid to react with the nicotine to generate the nicotine salt, and the prepared atomized liquid has better taste and no peculiar smell.
In the preparation of acidic electrolyzed water, potassium carbonate may be replaced by other salt electrolytes such as sodium carbonate, sodium bicarbonate, potassium hydroxide.
Variations and modifications to the above would be obvious to persons skilled in the art to which the invention pertains from the foregoing description and teachings. Therefore, the invention is not limited to the specific embodiments disclosed and described above, but some modifications and changes of the invention should be also included in the scope of the claims of the invention. In addition, although specific terms are used in the present specification, these terms are for convenience of description only and do not constitute any limitation on the invention.
Claims (7)
1. A novel nicotine salt characterized in that:
Is prepared by mixing acidic electrolyzed water, organic acid, glycerol and nicotine for reaction;
According to mass percentage, 5-20 parts of acidic electrolyzed water, 1-10 parts of organic acid, 10-30 parts of nicotine and 40-80 parts of glycerol;
the pH value of the acidic electrolyzed water is 2-5;
The method comprises the following steps:
(A) Adding acidic electrolyzed water and organic acid into nicotine, mixing and stirring;
(B) And adding glycerol for mixing reaction.
2. The novel nicotine salt of claim 1, wherein the acidic electrolyzed water is obtained by using a salt electrolyte, adjusting the electrolysis time, and then electrolyzing the acidic electrolyzed water by an electrolyzed water generator, and filtering the acidic electrolyzed water by an anode membrane.
3. The novel nicotine salt of claim 2, wherein the salt-adding electrolyte is selected from the group consisting of food-grade potassium carbonate.
4. The novel nicotine salt of claim 1, wherein the organic acid is one or more of benzoic acid, lactic acid, dihydroxybenzoic acid, vanillic acid, cinnamic acid, nicotinic acid, salicylic acid, sorbic acid, levulinic acid.
5. The novel nicotine salt of claim 1, wherein step (B) is carried out by mixing with a magnetic stirrer for 3-4 hours.
6. An atomized liquid characterized in that the novel nicotine salt is obtained by sequentially adding propylene glycol and glycerol, mixing and stirring the mixture according to any one of claims 1-5.
7. The atomized liquid according to claim 6, wherein the nicotine salt is 10-20 parts, propylene glycol is 50-60 parts, and glycerol is 30-40 parts by mass.
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| CN116965583A (en) * | 2023-06-15 | 2023-10-31 | 东莞市吉纯生物技术有限公司 | Homogeneous oily nicotine salt, preparation method and atomized liquid applied by same |
| CN116941812A (en) * | 2023-08-11 | 2023-10-27 | 东莞市吉纯生物技术有限公司 | Composite nicotine salt and faint scent type atomized liquid |
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| CZ2021255A3 (en) * | 2021-05-25 | 2022-12-07 | Consumer Brands International s.r.o. | Mixture of nicotine salts and producing it |
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| WO2006004646A1 (en) * | 2004-06-28 | 2006-01-12 | Nektar Therapeutics | Aerosol formulation comprising nicotine salt |
| WO2011034723A1 (en) * | 2009-09-16 | 2011-03-24 | Duke University | Improved device and method for delivery of a medicament |
| CN102423110A (en) * | 2011-07-24 | 2012-04-25 | 红云红河烟草(集团)有限责任公司 | Method for improving smoking quality of high-nicotine cigarettes |
| CN111039715A (en) * | 2019-12-20 | 2020-04-21 | 西南科技大学 | A kind of multi-effect nicotine water preparation and preparation method thereof |
| CN111187250B (en) * | 2020-01-08 | 2023-04-07 | 深圳黑尔格科技有限公司 | Method for preparing optically active nicotine in split mode |
| EP4094594A1 (en) * | 2021-05-25 | 2022-11-30 | Consumer Brands International s.r.o. | A filing of a nicotine formulation, in particular a nicotine sachet and the method of its manufacture, and a mixture of nicotine salts and the method of its manufacture |
| CN114343229B (en) * | 2022-01-24 | 2023-03-10 | 深圳市真味生物科技有限公司 | Preparation method of novel nicotine salt |
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| CZ2021255A3 (en) * | 2021-05-25 | 2022-12-07 | Consumer Brands International s.r.o. | Mixture of nicotine salts and producing it |
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