CN115836990B - Multi-effect body repair composition, skin care preparation and application thereof - Google Patents
Multi-effect body repair composition, skin care preparation and application thereof Download PDFInfo
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Abstract
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to a multi-effect body repair composition, a skin care preparation and application thereof. The invention provides a multi-effect body repairing composition, a skin care preparation and application thereof. Experiments prove that the multi-effect repairing composition can synergistically improve the effects of relieving inflammation, moisturizing, resisting oxidation, repairing and the like; meanwhile, the skin care preparation containing the multi-effect body repair composition is a common formulation of skin care products, has good stability, is safe and mild, and can provide a safe and easily-realized skin care product scheme for the adjuvant treatment of dermatitis eczema, xerosis cutis and psoriasis.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to the field of IPC A61K8, and more particularly relates to a multi-effect body repair composition, a skin care preparation and application thereof.
Background
Along with the improvement of living standard, people pursue beauty more and more, and in recent years, in addition to hair cosmetics and facial cosmetics, the demands of body cosmetics are obviously increased. The body lotion can play a role in moistening skin, can supplement water and nutrients for the skin, prevent the skin from drying and lack of water, and can form a layer of protective film on the surface of the skin to slow down the loss of the skin water. However, as the problems of working pressure, environmental pollution and the like are increasingly aggravated, skin problems such as red swelling, desquamation, itching and the like are likely to occur in most people, even more and more skin diseases such as body dermatitis eczema, xeroderma, psoriasis and the like occur in people, and the skin problems such as dermatitis eczema, xeroderma and psoriasis all have common problems such as dry skin, itching, sensitivity to physical stimulus, easiness in redness due to ultraviolet and UV injury and the like, and expert treatment suggests that skin cream with the effects of relieving, repairing and moisturizing are often used daily as an auxiliary treatment means. Thus, the body care product for moisturizing only can not meet the body care requirements of people.
In the prior art, the patent application document with the authority of publication number CN109223669B discloses a spray type moisturizing body lotion and a preparation method thereof, and the body lotion is prepared into a spray type, so that the body lotion is very convenient to carry when in use, can achieve the effect of refreshing and moisturizing for a long time, but has no obvious improvement on the skin repairing effect.
Patent document CN112043630B discloses a composition for preparing body milk, body milk containing the composition and a preparation method thereof, which can reduce melanin generation and delay skin aging by adding three components of bamboo leaf flavone, panthenol and shea butter, but the function of repairing skin and the stability of the product per se are not obviously improved.
Disclosure of Invention
In order to solve the problems, the invention combines the forefront skin care concept and theoretical basis with the Chinese thousand years Chinese herbal medicine skin care experience, selects a plurality of plant compounds, and screens out the synergistic multi-effect body repair composition through scientific proportioning and experimental verification. The first aspect of the invention provides a multi-effect body repair composition, which is prepared from the following raw materials in parts by weight: 0.01-1.0 part of boswellia serrata resin extract, 0.1-2.0 parts of hydrogenated starch hydrolysate, 0.01-1.0 part of caper fruit extract, 0.01-1.0 part of citrus fruit extract, 0.01-0.2 part of blue eucalyptus oil and 0.01-0.2 part of carboxymethyl chitosan.
The water content of the horny layer is reduced, so that the horny layer is changed from full and tough under healthy state to flat and brittle, and the horny layer is easy to tilt and break. The skin is easy to generate scales from the surface of the skin, and the scales fall off after external friction, so that microscopic wounds invisible to naked eyes can be formed on the surface of the skin. For people with insufficient resistance, minor wounds can cause serious skin infections. For example, for diabetics, a tiny wound on the foot can cause bacterial infection, and finally the foot turns into diabetic foot, and serious people can even cause amputation and death, and the physical and mental effects of patients are seriously affected.
The inventor finds in experiments that the skin care preparation can bring an auxiliary treatment scheme for dermatitis eczema, psoriasis and xerosis cutis in the aspect of body care by adding the boswellia serrata resin extract, the hydrogenated starch hydrolysate, the cape jasmine fruit extract, the citrus fruit extract, the eucalyptus oil and the carboxymethyl chitosan and by optimizing active ingredients and scientific proportion, achieves the synergistic promotion of various effects of moisturizing, relieving and repairing, and has safe and easily obtained sources of raw materials of each active ingredient in the effect composition and good application prospect.
The Latin chemical name of the boswellia serrata is: boswellia species.
Preferably, the boswellia serrata resin extract comprises, by weight, 25-49.99% of boswellia serrata resin extract, 25-49.99% of lecithin, 25-49.99% of microcrystalline cellulose and 1-4.99% of silica.
In some preferred embodiments, the boswellia serrata resin extract is purchased from BOSEXIL boswellia serrata phospholipid complex manufactured by Qihai Hua Du daily fragrance and flavor (Shanghai) limited.
Preferably, the hydrogenated starch hydrolysate contains maltotriose, maltotriose alcohol, glycosyl trehalose and water.
In some preferred embodiments, the hydrogenated starch hydrolysate is purchased from MG60C, manufactured by Shanghai Hui Xin biotechnology Co.
The Latin chemical name of the caper is as follows: capparisspinosa l.
Preferably, the caper contains stachydrine, alkaloid, water, glycerol, 1, 2-hexanediol and ethylhexyl glycerol.
In some preferred embodiments, the caper fruit extract is purchased from Shanghai Jia Kai biotechnology Co., ltd.) in a Zhiyan (GMOIST CS).
The Latin chemical name of the citrus is as follows: citrus reticulata Blanco.
Preferably, the citrus fruit extract contains flavone, alkaloid, water and butanediol.
In some preferred embodiments, the citrus fruit extract is purchased from Yufuning (CALMNERV CR) manufactured by Shanghai Jia Kai Biotech Co.
The alkaloid is a nitrogenous basic organic compound existing in nature, has the property of being similar to alkali, most of the alkaloid has a complex annular structure, most of the alkaloid is contained in the ring, has obvious biological activity, is one of important effective components in Chinese herbal medicines, and can improve the anti-allergy and anti-inflammation effects of the product and simultaneously has a certain anti-irritation effect when the product containing the alkaloid is applied to the field of cosmetics. Most alkaloids are however hardly or poorly soluble in water. The inventor screens a plurality of plants containing alkaloid through a large number of experiments, most of substances and other active substances in the invention cannot be completely dissolved in water, and precipitation and layering occur. Finally, the inventor finds that the 'stachydrine' in caper fruits and citrus fruits can be completely water-soluble with other active substances in the invention, and the activity is exerted to the greatest extent. The Latin chemical name of the eucalyptus globulus is: eucalyptus globusLabill.
Preferably, the content of 1, 8-cineole in the eucalyptus globulus oil is more than or equal to 80wt%.
In some preferred embodiments, the eucalyptus oil is purchased from Pure Eucalyptus oil% eucalyptus oil 80% manufactured by the international trade company, fine Teng (Shanghai).
In some preferred embodiments, the carboxymethyl chitosan is purchased from MHA MICRO manufactured by Shanghai spring dew biochemistry limited.
Preferably, the weight ratio of caper fruit extract to boswellia serrata resin extract is (6-18): 1.
To reduce body water loss and regulate the damage degree of UV to skin, the inventor found in practice that when the weight ratio of caper fruit extract to boswellia serrata resin extract is (6-18): 1, the damage degree of UV to the damage can be regulated, the moisturizing and water locking passage can be intelligently regulated, the skin self-protection and repair mechanism under the conditions of high temperature, solar radiation and extreme drought can be realized, and the water loss of an organism can be reduced. The method is probably due to the synergistic effect between caper fruit extract rich in stachydrine and other alkaloids and boswellia serrata resin extract rich in boswellic acid and other terpenes, on one hand, the affinity of skin to boswellic acid can be improved through a phospholipid complex transfer system, so that the boswellic acid is better absorbed by the skin to exert the skin care effect, on the other hand, the method has a good repairing effect on tearing damage caused by mechanical and physical friction, is beneficial to timely repairing of micro wounds, and in addition, the effect of preventing and relieving UV damage and effectively improving eczema and psoriasis is achieved by the synergistic effect of the caper fruit extract and the boswellia serrata resin extract.
Preferably, the weight ratio of the eucalyptus globulus oil to the citrus fruit extract is 1: (6-20).
The inventors found in experiments that when the multi-effect body repair composition contains specific eucalyptus oil and citrus fruit extract, the weight ratio of eucalyptus oil to citrus fruit extract is 1: (6-20) not only can relieve external stimulus and bring a relaxed feeling, but also can improve the tolerance of the skin in question to various stimuli. This is probably because, on the one hand, the eucalyptus oil has a strong inhibition effect on suppurative bacteria and staphylococcus aureus, has a good inhibition effect on pseudomonas aeruginosa, escherichia coli, cholera suis, shigella flexneri, shigella sonnei and tubercle bacillus, and can reduce the probability of bacterial infection when a micro wound occurs, and on the other hand, the eucalyptus oil can also improve the effect of inhibiting TRPV1 activation of citrus fruit extracts, thereby reducing calcium ion inflow, relieving burning, redness and stinging generated when wounds and sensitive skin are stimulated, and simultaneously improving the tolerance and the comfort of the skin to various stimuli. In addition, the eucalyptus oil with the 1, 8-cineole content of more than or equal to 80 weight percent has pure and non-pungent taste, and can bring a plant medicine with pleasant feeling.
Preferably, the weight ratio of the hydrogenated starch hydrolysate to the citrus fruit extract is (2-8): 1.
Preferably, the weight ratio of the hydrogenated starch hydrolysate to the carboxymethyl chitosan is (40-110): 1.
Because the components of the multi-effect body repair composition contain various chemical components such as sugar alcohol (carboxymethyl chitosan), flavone (citrus fruit extract) and the like, the stability of the system can be influenced. The solubility of active ingredients such as plant flavone is poor; sugar alcohol is easy to crystallize, affects the stability of the system, and needs to be stable in suspension and an anti-crystallization system to achieve stability. Therefore, in order to ensure the stability of the product, the inventors have shown through a number of experiments that when the weight ratio of hydrogenated starch hydrolysate to citrus fruit extract is (2-8): 1, and the weight ratio of hydrogenated starch hydrolysate to carboxymethyl chitosan is (40-110): 1, the three raw materials can be cooperated, and the addition of a proper amount of hydrogenated starch hydrolysate can improve the moisturizing effect of the multi-effect body repair composition on one hand, and can inhibit the conditions of difficult dissolution and easy crystallization of sugar alcohol and flavone on the other hand, so that the stability of the multi-effect body repair composition can be improved.
However, when the multi-effect body repair composition prepared by the application is applied to skin care preparations, the main chemical components of the boswellia serrata resin extract are diterpene and triterpene, so that the boswellia serrata resin extract is not easy to dissolve in water and easy to crystallize, and serious consequences such as precipitation, layering and the like are easily caused by direct addition in the preparation, thus influencing the stability of the preparation. The eucalyptus oil is an oil-soluble component and cannot be directly compatible with water-soluble components in the composition, and a stable system can be formed after emulsification. Thus, to ensure product stability, the compositions of the present application must be designed to incorporate specific emulsifiers or stabilizers into body milk formulations or other formulations.
The second aspect of the present invention provides a skin care formulation comprising the multi-effect body repair composition, which is prepared from the following raw materials in percentage by weight: the multiple effect body repair composition is 0.1-5%, and the skin care preparation matrix supplements the rest.
Preferably, the skin care formulation matrix comprises a phase a and a phase B.
Preferably, the A phase comprises an aqueous phase matrix A-1 and an oil phase matrix A-2.
Preferably, the A-1 phase comprises the following raw materials in percentage by weight of the skin care preparation: 3-11% of humectant, 0.2-1% of thickener, 0.05-0.2% of chelating agent, 0.2-1.0% of first skin conditioning agent and the balance of water-supplementing skin care preparation to 100%.
Preferably, the humectant is one or more of glycerol, lactic acid, 1, 3-propanediol, allantoin, betaine, ceramide, sodium hyaluronate, butanediol, 1, 2-pentanediol, and glycereth-26; further preferred are glycerol and glycerol polyether-26.
Preferably, the weight ratio of the glycerol to the glycerol polyether-26 is (2-8): (1-3).
In some preferred embodiments, the glycerol is purchased from Palm-Oleo Sdn. Bhd. Manufactured at PALMERA G995V.
In some preferred embodiments, the glycerolyether-26 is purchased from VANTAGE SPECIALTY INGREDIENTS, inc. manufactured LIPONIC EG-1.
Preferably, the thickener is one or more of PEG-150 distearate, acrylic acid (ester) copolymer, carbomer and xanthan gum; further preferred are carbomers and xanthan gum.
Preferably, the weight ratio of carbomer to xanthan gum is (1-2): (1-2).
In some preferred embodiments, the carbomers are purchased from Lubrizol ADVANCED MATERIALS, incUltrez 30Polymer。
In some preferred embodiments, the xanthan gum is purchased from CP KELCO u.s., incCG-SFT Xanthan Gum。
Preferably, the chelating agent is disodium EDTA.
In some preferred embodiments, the disodium EDTA is purchased from distolvine NA2 produced by Akzo Nobel Surface CHEMISTRY LLC.
Preferably, the first skin conditioner is one or more of hydroxyacetophenone, dipotassium glycyrrhizinate, allantoin, plant extract, fungus extract, ceramide and ascorbic acid; further preferred are p-hydroxyacetophenone and dipotassium glycyrrhizinate.
Preferably, the weight ratio of the p-hydroxyacetophenone to the dipotassium glycyrrhizinate is (1-2): (1-2).
In some preferred embodiments, the p-hydroxyacetophenone is purchased from BINPRES NYX, manufactured by Shanghai Violet biological medicine Co.
In some preferred embodiments, the dipotassium glycyrrhizinate is purchased from Gansu panto pharmaceutical Co.
Preferably, the A-2 phase comprises the following raw materials in percentage by weight of the skin care preparation: 7-22% of softening agent, 0.1-0.5% of antioxidant and 1.0-3.0% of emulsifier.
Preferably, the emollient comprises 1.0-5.0% butter tree (BUTYROSPERMUM PARKII), caprylic/capric triglyceride 1.0-3.0%, C12-13 alcohol lactate 1.0-3.0%, polydimethylsiloxane 1.0-3.0%, petrolatum 1.0-3.0%, isohexadecane 1.0-3.0%, cetostearyl alcohol 1.0-2.0%.
In some preferred embodiments, the Butyrospermum parkii fruit lipid is purchased from REFINED SHEA button manufactured by Cargill BV.
In some preferred embodiments, the caprylic/capric triglyceride is purchased from IMEX MCT/40 manufactured by INTERMED ESTERS sdn.
In some preferred embodiments, the C12-13 alcohol lactate is purchased from COSMACOL ELI of Saxole (China) chemical Co.
In some preferred embodiments, the polydimethylsiloxane is purchased from Wake chemistry (China) IncDM 350。
In some preferred embodiments, the petrolatum is purchased from BINESTER TM LV manufactured by Shanghai Violet biological medicine Co.
In some preferred embodiments, the isohexadecane is purchased from PUROLAN IHD manufactured by Langmuir Cheng Huaxue (China).
In some preferred embodiments, the cetostearyl alcohol is purchased from Emery Imuli company under the trade designation EMERCOL C16-18:70 MY.
Preferably, the antioxidant is tocopheryl acetate.
In some preferred embodiments, the tocopheryl acetate is purchased from VITAMIN E ACETATE manufactured by Zhejiang NHU co.ltd.
Preferably, the emulsifier is one or more of glyceryl stearate citrate, hydrogenated lecithin, cetostearyl oleate/sorbitan olive oleate.
In some preferred embodiments, the glyceryl stearate citrate is purchased from Evonik Operations GmbHGSC。
In some preferred embodiments, the hydrogenated lecithin is purchased from Soya SPL 75H manufactured by sco biotechnology limited, su.
In some preferred embodiments, the cetostearyl oleate/sorbitan olive oleate is purchased from OLIVEM 1000 manufactured by HALLSTAR ITALIA SRL.
In some preferred embodiments, the emulsifier comprises at least glyceryl stearate citrate.
Preferably, the weight percentage of the glyceryl stearate citrate in the emulsifier is more than or equal to 90 percent.
Preferably, the weight ratio of the hydrogenated starch hydrolysate to the emulsifier is (4-20): 25.
According to the invention, through research and test on various emulsifying agents and stabilizing agents, the finally selected emulsifying agent at least comprises glycerol stearate citrate, the weight percentage of the glycerol stearate citrate in the emulsifying agent is more than or equal to 90%, the hydrogenated starch hydrolysate is matched with the glycerol stearate citrate, and the weight ratio of the hydrogenated starch hydrolysate to the emulsifying agent is (4-20): 25, it was realized that the formulation enriched in the multi-effect body repair composition of the present invention exhibited excellent stability in both the 3 month failure test and the multiple centrifugation acceleration test.
Preferably, the raw materials of the phase B comprise, by weight percent of the skin care preparation: 0.2-0.7% of pH regulator, 0.1-1% of second skin conditioner and 0.1-1% of preservative.
Preferably, the pH regulator is one or more of citric acid, sodium citrate, arginine, malic acid and succinic acid; further preferred are sodium citrate and arginine.
Preferably, the weight ratio of the sodium citrate to the arginine is (0.5-2): (1-5).
In some preferred embodiments, the sodium citrate is purchased from sodium citrate produced by the febufakuda, inc.
In some preferred embodiments, the arginine is purchased from BINACTI AR manufactured by Shanghai Violet biological medicine Co.
Preferably, the second skin conditioning agent is one or more of panthenol, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, and ethylhexyl glycerol; further preferred is panthenol.
In some preferred embodiments, the panthenol is purchased from D-panthenol (G) manufactured by Hangzhou Xinfu technologies Co.
Preferably, the preservative is one or more of octanoyl hydroxamic acid, glycerol octanoate, sodium hydroxymethyl glycinate, hydroxybenzoate, butylhydroxytoluene and imidazolidinyl urea; further preferred are octanoyl hydroxamic acid and glycerol octanoate.
In some preferred embodiments, the preservative is purchased from NAGO AM91, manufactured by Ai Zhuo biotechnology, inc.
The body cream base of the multi-effect body grooming composition of the present invention is not limited to the ingredients within the above-described component a and component B, and other conventional skin conditioning agents may be added to meet product design requirements for better experience.
The skin care preparation containing the multi-effect body repair composition of the invention contains scientific proportions of the multi-effect body repair composition of the invention, and also contains skin care auxiliary raw materials and other characteristic additives common in the industry, wherein the skin care auxiliary raw materials comprise but are not limited to common plant extracts, skin conditioning agents and other components, such as nicotinamide, methyl propylene glycol, allantoin, phytosterol oleate, phytosterols, 1, 2-pentanediol, sodium hyaluronate, acetylated sodium hyaluronate, sodium hyaluronate crosslinked polymers, hydrolyzed sodium hyaluronate, ethylhexyl glycerin, stem extracts of dendrobium nobile (DENDROBIUM NOBILE), ALOE vera (ALOE bardebanensis) leaf extracts, radix sophorae flavescentis (SOPHORA FLAVESCENS) root extracts, lycium BARBARUM (LYCIUM barbar) fruit extracts, echinacea purpurea (ECHINACEA PURPUREA) extracts and other relevant raw materials.
The skin care preparation is only one proportion, and the multi-effect body repair composition can be applied to most conventional cosmetic preparations such as any essence, cream, bath lotion and the like from the viewpoint of product requirements.
The preparation method of the multi-effect body repair composition skin care preparation comprises the following steps:
s1: pre-weighing the A-1 component materials, adding the A-1 component materials into a water phase pot, homogenizing and dispersing uniformly, starting stirring and heating, heating to 75-85 ℃, and preserving heat and stirring for 10 minutes for later use;
s2: pre-weighing the A-2 component materials, adding the A-2 component materials into an oil phase pot, starting stirring and heating, heating to 70-80 ℃, and dispersing until uniformity is achieved for later use;
S3: preheating the emulsifying pot to about 60 ℃, pumping substances in the water phase pot for heat preservation to the emulsifying pot, pumping substances in the oil phase for heat preservation to the emulsifying pot, starting homogenizing at 3000-3500rpm for 5-10 min, stirring and cooling after uniformly mixing;
S4: when the temperature is reduced, adding the material of the component B phase, and stirring and mixing uniformly;
S5: cooling to 40-45deg.C, adding pre-weighed C component material, cooling to 1000-2500rpm, homogenizing for 5-10 min, and stirring to mix well;
s6: cooling to 30-38deg.C, detecting pH value of the material, sieving with 200 mesh sieve, and discharging.
The third aspect of the invention provides application of the multi-effect body repair composition, which can be applied to conventional cosmetic preparations such as skin care preparations, body milks, body creams, cream, essence, body washes and the like.
The beneficial effects are that:
1. The multi-effect repairing composition provided by the invention comprises the boswellia serrata resin extract, the hydrogenated starch hydrolysate, the cape jasmine fruit extract, the citrus fruit extract, the blue eucalyptus oil and the carboxymethyl chitosan, and achieves the synergistic promotion of various effects of moisturizing, relieving and repairing through preferential active ingredients and scientific proportion, the skin care preparation can bring an auxiliary treatment scheme for dermatitis eczema, psoriasis and xerosis cutis in the aspect of body care, and the active ingredient sources in the effect composition are safe and easy to obtain, and the application prospect is good.
2. According to the multi-effect repairing composition provided by the invention, the damage degree of UV to injury and the intelligent regulation and control of a moisturizing and water-locking passage can be realized by limiting the weight ratio of caper fruit extract to boswellia serrata resin extract, so that the skin self-protection and repairing mechanism under the conditions of high temperature, sunlight radiation and extreme drought can be realized, and the water loss of an organism can be reduced.
3. According to the multi-effect repairing composition provided by the invention, through limiting the weight ratio of the eucalyptus oil and the citrus fruit extract, external stimulus can be relieved, a relaxed feeling is brought, and the tolerance of the skin in question to various stimulus can be improved.
4. The multiple-effect body repair composition provided by the invention can improve the moisturizing effect of the multiple-effect body repair composition by limiting the weight ratio of the hydrogenated starch hydrolysate to the citrus fruit extract and the weight ratio of the hydrogenated starch hydrolysate to the carboxymethyl chitosan, and can improve the stability of the multiple-effect body repair composition by inhibiting the conditions of difficult dissolution and easy crystallization of sugar alcohol and flavone.
5. By adding specific emulsifying agents to the skin care formulation, the type of emulsifying agents and the ratio of the emulsifying agents to hydrogenated starch hydrolysates are limited, so that the formulation rich in the multi-effect body repair composition of the invention shows excellent stability in both a 3-month breaking test and a multiple centrifugation acceleration test.
6. According to the invention, the safety of the multi-effect body repair composition and the skin care preparation thereof can be improved, the probability of adverse reaction is reduced, and the skin care preparation rich in the multi-effect body repair composition shows high safety in an LC50 safety experiment by limiting the weight ratio of caper fruit extract to mastic resin extract of leaves and limiting the weight ratio of eucalyptus oil to citrus fruit extract.
7. The multi-effect body repair composition provided by the invention is prepared from carefully selected raw materials containing specific active ingredients through scientific compounding and synergistic effect; the skin care preparation containing the multi-effect body care composition is a common body skin care preparation, is easy to popularize, and is verified by experiments that the prepared skin care preparation has various body care effects of moisturizing, relieving, repairing and the like, and a new scheme is provided for the auxiliary treatment of dermatitis eczema, psoriasis and xeroderma.
Drawings
FIG. 1 is a bar graph showing the results of skin moisture content measurements before, after 7, and after 14 days using the skin care formulation prepared in example 1;
FIG. 2 is a bar graph showing the results of skin moisture content measurements before (0 weeks), after 7 days, and after 14 days using the skin care formulation prepared in example 1;
FIG. 3 is a bar graph showing the results of TEWL test before (0 days), after 7 days, and after 14 days of using the skin care preparation prepared in example 1.
Detailed Description
Specific examples of skin care formulations containing multi-effect body repair compositions are shown in tables 1 and 2. The raw material purchasing manufacturers in examples 1 to 12 are all preferred manufacturers mentioned in the specification. Examples 1-12 all employ the same manufacturing process, and the method of making the skin care formulation comprising the multi-effect body grooming composition comprises the steps of:
S1: pre-weighing the A-1 component materials, adding the A-1 component materials into a water phase pot, homogenizing and dispersing uniformly, starting stirring and heating, heating to 80 ℃, and preserving heat and stirring for 10 minutes for later use;
S2: pre-weighing the A-2 component materials, adding the A-2 component materials into an oil phase pot, starting stirring and heating, heating to 75 ℃, and dispersing until uniformity is achieved for later use;
s3: preheating an emulsifying pot to about 60 ℃, pumping substances in a water phase pot for heat preservation to the emulsifying pot, pumping substances in an oil phase for heat preservation to the emulsifying pot, starting homogenizing at 3300rpm for 8 minutes, and starting stirring and cooling after uniform mixing;
S4: when the temperature is reduced, adding the material of the component B phase, and stirring and mixing uniformly;
s5: cooling to 43 ℃, adding the pre-weighed C component material, reducing the homogenizing speed to 1800rpm, homogenizing for 8 minutes, and continuously stirring until the materials are uniformly mixed;
S6: and (5) cooling to 35 ℃, detecting the pH value of the material, and discharging through a 200-mesh screen after the pH value is qualified.
TABLE 1
TABLE 2
Performance test method
1. Centrifugal acceleration test
The skin care formulations prepared in examples 1 to 12 were evaluated for whether the skin care formulations satisfied no precipitation, no delamination of the color of the botanical composition by a plurality of centrifugal acceleration tests, and specific parameters and results are shown in Table 3.
TABLE 3 Table 3
Table 3 shows that examples 1-3 and examples 10-12 meet 3 accelerated centrifugation, examples 1-3 and examples 10-12 have good compatibility and stability with respect to the multi-effect body-care composition and its skin care formulation, and can meet the market demand, examples 4 and example 6 do not add glyceryl stearate citrate, example 5 add less glyceryl stearate citrate, example 7 and example 8 add less hydrogenated starch hydrolysate, but relatively speaking, example 8 is added in an amount closer to the range to be protected by the present application, so that its centrifugation at 2000rpm is OK, but 3000rpm and above begins layering; the absence of the addition of hydrogenated starch hydrolysates in example 9 has affected the stability of multi-effect body repair compositions and skin care formulations thereof.
The emulsifiers, stabilizers and other formulation ingredients in examples 4, 5, 6 and 7 are all classical ingredients commonly used in the industry, but after the multi-effect body repair composition related to the invention is added, how to make the formulation product meet multiple centrifugation experiments and high-low temperature damage experiments becomes a point of easy failure in the research and development process of the industry, and is also a technical difficulty to be solved in the industry. The inventor proves that a large number of experiments prove that the technical difficulties can be solved only by scientifically proportioning specific raw materials and playing the synergistic effect of the raw materials.
2. Temperature stability
The skin care preparations prepared in examples 1 to 3, 8 and 10 to 12 were placed at-15℃and 42℃and room temperature (25 ℃) for 30 days, 60 days and 90 days, respectively, and whether the preparation system did not precipitate, did not separate out the plant composition color was observed, and the test results are shown in Table 4.
TABLE 4 Table 4
The results in Table 4 show that examples 1-3 and examples 10-12 maintain good stability at low, normal and high temperatures, and can meet the market demand, also due to the synergistic effect between the stabilizers and emulsifiers in the feed. The amount of hydrogenated starch hydrolysate in example 8 is outside the scope of the present application and therefore affects the high and low temperature stability of the multi-effect body repair composition and its skin care formulation.
3. Safety experiment
Zebra fish is one of the alternative species currently used in human health and ecological hazard assessment, and the toxic response of zebra fish can be predictive of the toxic response of mammals. When the skin is exposed to living environment, skin inflammation to a certain extent can be caused after the skin is contacted with toxic and harmful substances, and skin reddening, itching and the like can occur. Sodium dodecyl sulfonate (SLS) is a common positive control for human skin irritant model patch test, and can induce epidermal inflammatory cell infiltration after SLS stimulation, and the irritant enters the zebra fish body to induce inflammatory reaction. The median lethal concentration (LC 50) of the samples was determined by mortality of zebra fish under stimulation of SLS. The greater the LC50 value, the higher the sample safety. The experimental steps are as follows:
1. zebra fish were randomly selected in 6-well plates with 30 tails per well.
2. The water-soluble administration of SLS establishes a zebra fish skin inflammation model.
3. The samples of examples 1-3 and examples 10-12 were given water-soluble, respectively, with a 3mL per well capacity.
Incubate at 4.28℃for 18h in the absence of light.
5. After the end of the experiment, the mortality of each group of zebra fish was counted, analyzed with SPSS 26.0 software and LC50 was calculated. The results are shown in Table 5.
TABLE 5
As can be seen from table 5, under the present experimental conditions, the LC50 under SLS stimulation of examples 1,2, 3, 10, 11, 12 was 3.05%, 1.86%, 1.19%, 0.9%, 2.18%, 2.95%, respectively; the LC50 values for example 1 and example 6 were highest, presumably when the weight ratio of caper fruit extract to boswellia serrata resin extract was (6-18): 1, the weight ratio of eucalyptus globulus oil to citrus fruit extract is 1: (6-20) can improve the safety of the multi-effect body repair composition and the skin care preparation thereof and reduce the occurrence probability of adverse reactions.
4. Skin irritation test
Referring to cosmetic safety Specification (2015 edition), the skin care preparation prepared in example 1 was subjected to a plurality of skin irritation tests, and the results were scored, and the results are shown in Table 6.
TABLE 6
The results in Table 6 show that the multi-effect body repair composition prepared in example 1 and the skin care preparation containing the multi-effect body repair composition are mild and do not irritate, do not cause redness, burning and stinging, are safe to use, and can meet the market demands.
5. Pesticide content test experiment
The skin care preparation prepared in example 1 was tested for the content of pesticides and related chemicals with reference to GB 23200.8-2016 and the results are shown in Table 7.
TABLE 7
As can be seen from the data in table 7, the multi-effect body repair composition and the skin care preparation containing the multi-effect body repair composition prepared in example 1 of the present invention have no residue of chemicals such as pesticides, are safe in composition, and can meet the market demands.
6. Microorganism and physicochemical testing
The skin care preparation prepared in example 1 was subjected to microbiological and physicochemical tests with reference to cosmetic safety Specification (2015 edition) and the results are shown in tables 8 and 9.
TABLE 8
TABLE 9
As can be seen from tables 8 and 9, the multi-effect body care composition and the skin care preparation containing the multi-effect body care composition prepared in example 1 of the invention have low microorganism content, and the total number of colonies, the total number of mold and yeast, the heat-resistant coliform group, staphylococcus aureus and pseudomonas aeruginosa all meet the requirements of cosmetic safety technical Specification (2015 edition), and the contents of harmful heavy metals and dioxane are far lower than the requirements of cosmetic safety technical Specification (2015 edition). The skin care preparation has high safety and can meet the market demand.
7. Efficacy experiment: moisture content and percutaneous moisture loss (TEWL)
Skin care formulations containing the multi-effect body care composition prepared in example 1 were selected for each of 31 volunteers aged 20-50 years, each time on the inner side of the left arm, in the morning and evening, without using any product on the inner side of the right arm (blank control), the moisture content and the transdermal water loss rate of the skin before, after 7 days and after 14 days of use were tested, the moisture content of the skin was tested with a skin moisture tester, the transdermal water loss rate of the skin was tested with a skin moisture loss tester, the average value was taken, and the change rates of 7 days and 14 days were obtained by calculation, the measured data were recorded in tables 10-14, and the skin moisture content test results and TEWL test results were plotted as bar charts, respectively, as shown in fig. 1-3.
Table 10 moisture content (a.u.) test results
Table 11 statistical analysis results of moisture content before and after product use
Remarks: the significance labeling method comprises the following steps: "n.s." means no statistical difference, P.gtoreq.0.05; p < 0.05, P <0.01, P is a significant difference (a "×a:") and P is a significant difference (a "×a:")
Table 12 statistical analysis results of moisture content before and after use of the product
Remarks: the significance labeling method comprises the following steps: "n.s." means no statistical difference, P.gtoreq.0.05; p < 0.05, P <0.01, P is a significant difference (a "×a:") and P is a significant difference (a "×a:")
TABLE 13 TEWL (g/cm 2. H) test results
Table 14 statistical analysis of TEWL (g/cm 2. Multidot.h) before and after use of the product
Remarks: the significance labeling method comprises the following steps: "n.s." means no statistical difference, P.gtoreq.0.05; p < 0.05, P <0.01, P is a significant difference (a "×a:") and P is a significant difference (a "×a:")
The results showed that after 7 days and 14 days of continuous use of the samples, the skin moisture content of the subjects was significantly increased compared with the control group, and the increase rates were 151.53% and 215.79%, respectively. After 7 days and 14 days of continuous use of the sample, the skin moisture content of the subject and the skin moisture content of the subject before use are obviously increased, and the lifting rates are 97.44% and 124.81% respectively. After 7 days and 14 days of continuous use of the samples, the TEWL values of the subjects were significantly reduced compared with the control group, with the downregulation rates being 220.5% and 134.66%, respectively. This shows that the skin care preparation containing the multi-effect body repair composition prepared in the example 1 can achieve various effects of moisturizing, relieving and repairing, and can bring an auxiliary treatment scheme for dermatitis eczema, psoriasis and xerosis cutis in the aspect of body care, and has good application prospect.
Claims (7)
1. A multi-effect body repair composition is characterized by comprising the following preparation raw materials in parts by weight: 0.01-1.0 part of boswellia serrata resin extract, 0.1-2.0 parts of hydrogenated starch hydrolysate, 0.01-1.0 part of caper fruit extract, 0.01-1.0 part of citrus fruit extract, 0.01-0.2 part of blue eucalyptus oil and 0.01-0.2 part of carboxymethyl chitosan;
the weight ratio of caper fruit extract to boswellia serrata resin extract is (6-18): 1, a step of;
The weight ratio of the eucalyptus globulus oil to the citrus fruit extract is 1: (6-20);
the weight ratio of the hydrogenated starch hydrolysate to the citrus fruit extract is (2-8): 1, a step of;
the weight ratio of the hydrogenated starch hydrolysate to the carboxymethyl chitosan is (40-110): 1.
2. A skin care formulation comprising the multi-effect body repair composition of claim 1, characterized in that it is prepared from the following raw materials in weight percent: the multiple-effect body repair composition is 0.1-5% and the skin care preparation substrate supplements the balance.
3. The skin care formulation of claim 2 wherein the skin care formulation matrix comprises a phase a and a phase B; the phase A comprises an aqueous phase matrix A-1 and an oil phase matrix A-2; the A-1 phase comprises the following raw materials in percentage by weight: 3-11% of humectant, 0.2-1% of thickener, 0.05-0.2% of chelating agent, 0.2-1.0% of first skin conditioning agent and the balance of water-supplementing skin care preparation to 100%; the A-2 phase comprises the following raw materials: 7-22% of softening agent, 0.1-0.5% of antioxidant and 1.0-3.0% of emulsifier; the raw materials of the phase B comprise: 0.2-0.7% of pH regulator, 0.1-1% of second skin conditioner and 0.1-1% of preservative;
the first skin conditioner is one or more of hydroxyacetophenone, dipotassium glycyrrhizinate, allantoin, plant extract, fungus extract, ceramide and ascorbic acid;
The second skin conditioning agent is one or more of panthenol, sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, and ethylhexyl glycerin.
4. A skin care formulation according to claim 3, wherein the emulsifier is one or more of glyceryl stearate citrate, hydrogenated lecithin, cetostearyl oleate/sorbitan oleate; the weight percentage of the glycerol stearate citrate in the emulsifier is more than or equal to 90 percent; the weight ratio of the hydrogenated starch hydrolysate to the emulsifier is (4-20): 25.
5. A method of preparing a skin care formulation of the multi-effect body repair composition of claim 4 comprising the steps of:
s1: pre-weighing the A-1 component materials, adding the A-1 component materials into a water phase pot, homogenizing and dispersing uniformly, starting stirring and heating, heating to 75-85 ℃, and preserving heat and stirring for 10 minutes for later use;
s2: pre-weighing the A-2 component materials, adding the A-2 component materials into an oil phase pot, starting stirring and heating, heating to 70-80 ℃, and dispersing until uniformity is achieved for later use;
s3: preheating the emulsifying pot to 60 ℃, pumping substances in the water phase pot for heat preservation to the emulsifying pot, pumping substances in the oil phase for heat preservation to the emulsifying pot, starting homogenizing, wherein the homogenizing speed is 3000-3500rpm, homogenizing time is 5-10 minutes, and starting stirring and cooling after uniformly mixing;
S4: when the temperature is reduced, adding the material of the component B phase, and stirring and mixing uniformly;
s5: cooling to 40-45deg.C, adding the pre-weighed multiple-effect body repair composition, reducing homogenizing speed to 1000-2500 rpm, homogenizing for 5-10 min, and continuously stirring to mix well;
s6: cooling to 30-38deg.C, detecting pH value of the material, sieving with 200 mesh sieve, and discharging.
6. Use of the multi-effect body repair composition of claim 1 in the preparation of a skin care formulation.
7. Use of the multi-effect body repair composition according to claim 1 for the preparation of creams, essences, body washes.
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| EA025223B1 (en) * | 2010-02-19 | 2016-12-30 | Мэри Кей Инк. | Topical skin care formulation and method of increasing integrity of dermal-epidermal junction in skin tissues |
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