JP2010132629A - External composition for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external composition for skins, such as cosmetics or quasi-drugs, which simultaneously realizes the following three points: (1) sufficient moisture retention, (2) restoration of barrier function, and (3) latent anti-inflammation, and is effective for preventing skin ageing and promoting chronic dermatitis cure. <P>SOLUTION: The external composition for the skins contains (A) a mammalian placenta extract, (B) a yeast extract, (C) human oligopeptide-1(h-EGF: human epidermal growth factor), and (D) an essential oil extracted from a plant or steam-distilled water (aromatic distilled water). <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

Detailed Description of the Invention

  The present invention relates to an external composition for skin, and more particularly to an external composition for skin, such as cosmetics and quasi-drugs, effective in preventing skin aging and promoting healing of chronic dermatitis.

  When a foreign object enters a living body, the living body determines whether it is self or non-self. In the case of non-self, the immune system or the like is activated to start working to eliminate this foreign substance. Inflammation involving the immune system is called allergic inflammation, and inflammation not involving the immune system is called non-allergic inflammation.

  The onset mechanism of dermatitis is roughly divided into allergic and non-allergic. Non-allergic dermatitis causes tissue damage directly or indirectly. On the other hand, allergic dermatitis is caused by ingested or contacted substances such as fish and seafood, plants such as urushi, and daily necessities such as metal, rubber, and detergent, which produce cytokines, which are inflamed ( This occurs as a result of causing type I to V allergy. Inflammation caused by repeated contact with the causative agent causes chronic dermatitis, which is similar to what is called atopic dermatitis.

  There are generally four main types of inflammation: redness / erythema, pain, fever, and edema. These inflammatory reactions are a series of processes from tissue damage to repair and healing. Causes that cause damage to living tissues include heat, ultraviolet rays, acid / alkali, bacterial infection, and immune reaction. When a tissue is damaged, chemical mediators such as histamine, bradykinin, prostaglandins and leukotrienes are released from the producing cells, the capillaries are dilated, and redness / erythema and fever are induced. Furthermore, edema is caused by increased vascular permeability. These chemical mediators also act on sensory nerves and cause pain.

  When inflammation continues for a long time, a short rash period and a remission period are alternately repeated, resulting in disorder of the structure of the epidermal stratum corneum and a decrease in barrier function. As a result, the skin becomes dry and itchy. It becomes ugly and scratches, and the barrier function breaks down, creating a vicious circle that worsens the symptoms.

  Therefore, it is possible to promote the healing of chronic dermatitis by simultaneously realizing the following three points: (1) sufficient moisturizing, (2) repair of barrier function, and (3) suppressing potential inflammation. It is considered possible.

  Aging is a continuous process in which the normal control ability of a gene is altered by chronic inflammation and gradually loses its cell repair function. Therefore, it is considered that prevention of aging can be promoted by simultaneously realizing the above three points, (1) sufficient moisturizing, (2) repair of barrier function, and (3) suppressing potential inflammation. It is done.

  In the prior art, for example, in Patent Document 1, extracts from lindenaceae plants and α-hydroxycarboxylic acids, vitamins, placenta extract, spleen extract, fibroblast growth factor, epidermal growth factor and the like derived from animals An external preparation for skin comprising one or more selected from physiologically active substances is disclosed.

  In Patent Document 2, ascorbic acid and derivatives thereof, herbal medicines and extracts thereof, hydroxycarboxylic acids and salts thereof, placental extracts, mycelium cultures and extracts thereof, plant extracts and the like are mixed. Skin external preparations having a whitening effect, prevention of rough skin, improvement of rough skin, prevention of aging, and the like have been disclosed.

  The components used in Patent Document 1 and Patent Document 2 contain components that are considered to have a moisturizing effect and a cell activation effect, such as placenta extract, mycelium culture, and epidermal growth factor. The effect can be expected with respect to two points, i.e., sufficient moisture retention and (2) repair of the barrier function. However, there is room for further improvement in (3) reducing potential inflammation.

  JP-A-9-301880   JP 2006-169111 A

  By simultaneously realizing the following three points: (1) sufficient moisturizing, (2) repair of barrier function, and (3) relieving potential inflammation, it is possible to prevent skin aging and promote healing of chronic dermatitis. Provided are skin care compositions such as effective cosmetics and quasi drugs.

  A composition that is effective in preventing skin aging and promoting healing of chronic dermatitis may contain all ingredients that have sufficient moisturizing action, repair function of barrier function, and action to suppress potential inflammation. is necessary.

  Therefore, as a result of repeated research, (A) mammalian placenta extract, (B) yeast extract, (C) human oligopeptide-1 (h-EGF: human epidermal growth factor), and (D It was found that a composition for external use on the skin characterized by containing essential oil (essential oil) or steam distilled water (aromatic distilled water) extracted from plants was very effective.

  The placenta extract contains a component having a moisturizing action and a repair action of the stratum corneum barrier function. Examples of placenta extracts include those obtained by washing the placenta of mammals such as cows, pigs and horses, extracting blood-soluble components through means such as blood removal, crushing, and freezing, and further removing impurities. It is done. These are generally marketed as water-soluble placenta extracts and are used as cosmetic raw materials.

  Human oligopeptides are known to promote skin cell regeneration, activate cell tissues such as granulation by cell proliferation and tissue regeneration by angiogenesis, collagen accumulation, moisturize and firm skin, and repair barrier function. It is effective for.

  In order to calm potential inflammation, the production-suppressing action of inflammatory chemical mediators by plant-derived essential oil (essential oil) and steam distilled water (aromatic distilled water) is effective (Non-patent Document 1 and Non-Patent Document 2). .

  Essential oil, a volatile oil-soluble component extracted mainly from plant flowers and seeds by steam distillation and low-temperature pressing methods, is a volatile compound (aromatic compound and terpenoid compound) with a unique fragrance. is there. Essential oils have effects on the mind and body (sedative, analgesic, digestive / appetite-enhancing, hormone regulating, stimulating, tonic, immunostimulatory, diuretic, etc.) and skin (astringent, moisturizing) Etc.), action against bacteria, viruses, insects, etc. (bactericidal action, antibacterial action, antifungal action, antiviral action, insecticidal / insect repellent action, etc.), and it is known that the effect can be enhanced by combining multiple essential oils It has been.

  As a method for obtaining essential oil from plants, a method of separating essential oil from an oil layer by steam distillation is often used (Non-patent Document 3). In the case of steam distillation, a water-soluble fraction (referred to as steam distilled water or aromatic distilled water) transferred to the aqueous layer is obtained. Although distilled water is weaker in fragrance and physiological activity than essential oil, it is water-soluble and is therefore effectively used as a component of cosmetics and fragrances.

Andrzej T.M. Slominski et al. , Anals New York Academy of Sciences 885, 287-311 (1999) Andreas Natsch et al. , International Journal of Cosmetic Science 29 (5), 369-376 (2007) Masao Fujimaki et al. “Encyclopedia of Fragrances” p. 366, Asakura Shoten (1980)

  As described above, the external composition for skin of the present invention simultaneously realizes the following three points: (1) sufficient moisturizing, (2) repair of barrier function, and (3) calming potential inflammation. Thus, it is possible to provide a composition for external use on skin such as cosmetics and quasi-drugs effective in preventing skin aging and promoting healing of chronic dermatitis.

  EXAMPLES Hereinafter, the present invention will be specifically described by way of examples. However, this is merely for better understanding of the present invention, and is not intended to limit the present invention. Various aspects can be easily derived by those skilled in the art.

  The mixing ratio of typical drugs used in the present invention is selected in a wide range depending on the purpose and the properties of the final product to be obtained. For example, in the case of squalane, jojoba oil, etc., 0.0 wt% to 80.0 wt%, Behenyl alcohol is 0.0 wt% to 10.0 wt%, glyceryl stearate, lipophilic glyceryl monostearate, carboxyvinyl polymer, xanthan gum, sodium hyaluronate is 0.0 wt% to 5.0 wt%, 3-butylene glycol, glycerin, placenta extract, yeast extract and human oligopeptide are 0.1% to 10% by weight, and plant essential oil and plant steam distilled water are 0.001% to 1% by weight. You can also

[Formulation Example 1] Lotion cosmetic (skin lotion)
After stirring and dissolving paraoxybenzoic acid ester, sodium hyaluronate, xanthan gum 1,3-butylene glycol, and concentrated glycerin in purified water, placenta extract, yeast extract, plant steam distilled water, human oligopeptide, sodium chloride, flavor Dissolve to get a lotion-like cosmetic.

[Formulation Example 2] Gel Basic Cosmetic After stirring and dissolving carboxyvinylili polymer, paraoxybenzoate ester, sodium hyaluronate, xanthan gum, 1,3-butylene glycol, and concentrated glycerin in purified water, placenta extract, yeast extract Dissolve plant steam distilled water, human oligopeptide, and sodium chloride, and adjust the pH to 6.0 with potassium hydroxide solution to obtain a gel-like cosmetic.

[Prescription Example 3] Milky Cosmetics After stirring and dissolving paraoxybenzoic acid ester, sodium hyaluronate, xanthan gum, 1,3-butylene glycol, and concentrated glycerin in purified water, placenta extract, yeast extract, human oligopeptide, plant Steamed distilled water and sodium chloride were dissolved and heated, and then added separately to squalane, jojoba oil, vegetable essential oil, behenyl alcohol, glyceryl stearate, lipophilic glyceryl monostearate, and stirred. Cool to obtain an emulsion cosmetic.

[Formulation Example 4] Gel cream cosmetic After stirring and dissolving carboxyvinyl polymer, paraoxybenzoic acid ester, sodium hyaluronate, xanthan gum, 1,3-butylene glycol, and concentrated glycerin in purified water, placenta extract, yeast extract, Squalane, jojoba oil, vegetable essential oil, behenyl alcohol, glyceryl stearate and lipophilic glyceryl monostearate were separately heated and dissolved in human oligopeptides, vegetable steam distilled water, and sodium chloride. Add to the mixture and cool with stirring. Adjust to pH 6.0 with potassium hydroxide solution to obtain a gel cream cosmetic.

[Prescription Example 5] Creamy cosmetic product After stirring and dissolving paraoxybenzoate ester, sodium hyaluronate, xanthan gum 1,3-butylene glycol, and concentrated glycerin in purified water, placenta extract, yeast extract, human oligopeptide, plant water vapor Dissolved and heated in distilled water and sodium chloride, separately added squalane, jojoba oil, vegetable essential oil, behenyl alcohol, glyceryl stearate, lipophilic glyceryl monostearate, and stirred and cooled. To get creamy cosmetics.

  Specific plant essential oils include essential oils such as Aomoji fruit oil, Atlas cedar bark oil, Anise oil, Amyris balsamifera bark oil, Angelica root oil, Italian cypress oil, Ylang ylang flower oil, Indian lemongrass oil, Fennel Fruit oil, Fennel oil, Empizubixin oil, Prunus pericarp peel oil, Amanita palm peel oil, Onysarubia oil, Origanum Heracreoticum flower oil, Ormenis mulcauris oil, Orange flower oil, Carnation flower oil, Cassia leaf oil, Gajutsu root oil , Hydrolyzed peanut oil, canaryno resin oil, chamomile oil, cayupute oil, caraway fruit oil, caraway seed oil, cypress oil, gypsophila oil, camphor tree bark oil, gardenia oil, gizzard oil, grapefruit peel oil, kunze aerikoi Leaf oil, Keihi oil, Ghetto leaf oil, Caucus igaya oil, Pepper fruit oil, Coriander fruit oil, Cyberus esculenta root oil, Sassafras root oil, Pleurotus flower, Cicinbrium Irio seed oil, Sissula danifels resin, Siberian fir oil, musk, jasmine oil, junibel mexicana oil, ginger root oil, ginger seed oil, Genghis belsum sumnal root oil, sweet acacia flower oil, spike lavender oil, spearmint oil, red pine bulb oil, red pine leaf Oil, Hypericum persimmon oil, Persimmon fruit oil, Atlantic mint oil, Ceylon nicky bark oil, Sage geranium oil, Sentifolia rose flower oil, Daiwi oleander oil, Dio persimmon oil, Thyme oil, Pepper oil, Damask rose oil, Chimus mastina oil Tea leaf oil, clove bud oil, clove flower oil, clove leaf oil, clove oil, tea tree leaf oil, german spruce oil, pearl millet oil, pepper oil, violet oil, violet aquatic oil, violet hive oil, nutmeg nuclear oil , Sardine oil, wild rose oil, high pine oil, bakuchia citriodora leaf oil, lotus flower oil, parsley seed oil, patchouli oil, mint leaves oil, mint oil, vanilla fruit oil, palmarosa oil, bitter almond kernel oil, bitter Orange peel oil, hiba oil, cedar tree oil, cedar leaf oil, sandalwood oil, ferla galvanichur resin oil, fusanus spicus tree oil, petit gren oil, bay oil, vetiver root oil, hematococcus spruvialis oil, peru Balsam, Bergamot fruit oil, Hokubay Fuso oil, Boswellia Serata oil, Majorana Flower oil, Majorana leaf oil, Mandarin orange peel oil, Mandarin orange leaf oil, Mebuki oil, Melaleuca ericiphoria leaf oil, Melaleuca viriliflora leaf oil, Melissa leaf oil, Moscata rose oil, Japanese pearl jelly oil, Japanese maple oil, Willow mint leaf oil , Eucalyptus citriodora oil, eucalyptus leaf oil, eucalyptus oil, yuzu peel oil, yuzuboku oil, european fir leaf oil, european fir oil, lime oil, lavandula hybrida oil, labdanum oil, lavender oil, apple oil, leptosper Mum Petersony oil, lemon peel oil, lemongrass oil, lemon fruit oil, lemon leaf oil, rosewood tree oil, rosemary oil, rose oil, Lawson cypress tree oil, Roman chamomile flower oil, laurel oil, etc. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  Specific examples of plant steam distilled water (aromatic distilled water) include American Neko tree water, Alpinia uriensis stalk / leaf water, aloe vera leaf water, fennel water, ume fruit water, edelweiss water, orange fruit water, orange flower Water, Orange Flower Water, Oro Blanco Fruit Water, Cass Root Water, Chamomile Water, Kiwi Fruit Water, Kuzzura Flower Water, Grapefruit Fruit Water, Ghetto Leaf Water, Ghetto Flower / Leaf / Stem Water, Coco Palm Water, Rice Water Danifels leaf / stem water, ginger water, white-bellied fruit water, slow berry flower water, sudachi water, yellow squirrel leaf water, pear water, elderberry flower water, prunus fruit water, hazel leaf water, sage water, sage leaf Water, senkyu water, centifolia rose flower water, isanchik water, damask rose flower water, Shimazasa water, tea leaf water, camellia flower water, toki water, tomato fruit water, pineapple fruit water, hybrid rose water, lotus root water, lotus flower water, mint water, pearl seed water, banana flower water, madrid water, hamamelis water , Hamelis Flower Water, Mandarin Orange Water, Bitter Orange Flower Water, Cypress Water, Grape Fruit Water, Fuyubo Daiju Flower Water, Bodaiju Water, Melissa Water, Melon Fruit Water, Cornflower Flower Water, Eucalyptus Water, Yuzu Skin Water (Yuzu Water) Water, European raspberry fruit water, European birch water, Artemisia water, Lychee water, Lavender flower water, Apple fruit water, High pressure apple fruit juice, Lemon fruit water, Rose water, Rosemary water, Ronicera frog rare water , French lavender water, Kris Mum Mali Mum water, Helicris mu talikum water, Situs Mons There is such Rienshisu water. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  In the present invention, a substance selected from the group consisting of a thickener, a surfactant, a fragrance, a preservative, a colorant, a humectant, and a drug as necessary following the stirring and dissolution treatment of the water phase component and the oil phase component. Can be added and dissolved in the water phase component and the oil phase component according to the purpose.

  Examples of the oil phase component include solid oil, semi-solid oil, fluid oil, and surfactant. Moreover, as an oil phase component of this invention, you may further contain what was chosen from the group which consists of surfactant, a fragrance | flavor, an antiseptic | preservative, a coloring agent, a moisturizer, and a chemical | medical agent. Representative oil phase components of the present invention include, for example, fatty acids, higher alcohols, fatty acid esters, fats and oils, waxes, and surfactants.

  Specific oil components of the oil phase component include vegetable oils (almond oil, avocado oil, linseed oil, olive oil, kiwi seed oil, kukui nut oil, corn oil, sesame oil, safflower oil, shea fat, soybean oil, evening primrose Oil, camellia oil, rapeseed oil, castor oil, sunflower seed oil, grape seed oil, prune oil, macadamia nut oil, mango seed oil, palm oil, rosehip oil, apple seed oil, hydrogenated avocado oil, hydrogenated olive oil, water Additive shea fat, hydrogenated soybean oil, hydrogenated rapeseed seed oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated castor oil, hydrogenated sunflower seed oil, hydrogenated cottonseed oil, hydrogenated molasses, hydrogenated vegetable oil, water Coconut oil, animal fats (rabbit fat, emu oil, oil snake fat, fish oil, colostrum, turtle oil, ostrich oil, tuna oil, viper oil, waterfowl oil, mink oil, egg yolk oil, hydrogenated fish , Hydrogenated ostrich oil, hydrogenated pork fat, hydrogenated milk fat, hydrogenated mink oil, hydrogenated egg yolk fat oil, partially hydrogenated horse oil, etc.), wax (sea urchin peel wax, liquid lanolin, orange peel wax, orange luffy oil , Carnauba wax, candelilla wax, whale wax, hydroxylanolin, propolis wax, jojoba fat, beeswax, lanolin, rosemary flower wax, hydrolyzed jojoba ester, hydrolyzed beeswax, hydrogenated rice bran wax, hydrogenated jojoba oil, hydrogenated lanolin, Etc.), hydrocarbon oil ((C12,14) alkane, (C13,15) alkane, (C15,19) alkane, (C18,21) alkane, (C7,8) isoparaffin, (C9,11) isoparaffin, ( C11,13) Isoparaffin, (C13,16) Isoparaffin, (C18,70) Isoparaffin, Isoe Kosan, olefin oligomer, shark liver oil, squalane, tetradecene, mineral oil, petrolatum, hydrogenated didecene, hydrogenated polyisobutene, etc.), hydrocarbon wax (ozokerite olefin (C30-45), synthetic wax, microcrystalline wax, ceresin, Paraffins), fatty acids (stearic acid, oleic acid, linoleic acid, isostearic acid, myristic acid, palmitic acid, palmitoleic acid, ricinoleic acid, lauric acid, behenic acid, etc.), higher alcohols (cetanol, isocetyl alcohol, Stearyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl alcohol, octyldodecyl alcohol, oleyl alcohol, cholesterol, etc.), synthetic esters (isooctanoic acid Chill, isocetyl stearate phosphate, isopropyl isostearate, isopropyl myristate, 2-octyldodecyl myristate, isobutyl palmitate, hexadecyl adipate, cetyl 2-ethylhexanoate, diisostearyl malate, 16-hydroxypalmitate Seryl, ceryl palmitate, myricyl palmitate, cetyl palmitate, isopropyl laurate, hexyl laurate, glyceryl monoricinoleate, decyl oleate, di-n-butyl sebacate, glycerol tri-2-ethylhexanoate, glycerol tris Esters, pentaerythritol tetraesters, cholesteryl esters, etc.), silicone oils (methylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane) Sun, etc. cyclomethicone), and the like polyoxypropylene adducts. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  Specific examples of the surfactant include polyoxyethylene cetyl ether, polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene behenyl ether, polyoxyethylene / polyoxypropylene decyl ether Fatty acid ester, mono fatty acid glycerin, tri fatty acid glycerin, propylene glycol fatty acid ester, ethylene glycol fatty acid ester, monostearic acid polyethylene glycol monooleic acid polyethylene glycol, monolauric acid polyethylene glycol, polyoxyethylene hydrogenated castor oil, monostearic acid polyoxyethylene Glycerin, polyethylene glycol isostearate, polyoxyethylene castor oil, stearic acid Reoxyethylene cetyl ether, polyoxyethylene stearyl ether stearate, polyoxyethylene lauryl stearate, polyoxyethylene lauryl isostearate, polyethylene glycol dilaurate, polyethylene glycol distearate, polyethylene glycol diisostearate, polyethylene glycol dioleate, Polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit sorbitan fatty acid ester, polyoxyethylene glyceryl ether fatty acid ester, polyoxyethylene hydrogenated castor oil fatty acid ester, polyoxyethylene trimethylolpropane fatty acid ester, N-acyl glutamic acid ester, pyroglutamic acid Ester, polyglycerin fat Esters, and the like and silicone based surfactant. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  As fragrances, natural fragrances such as plant fragrances obtained from plants, animal fragrances obtained from animal gland sac, etc., synthesized from natural fragrances or synthesized chemically based on them Examples include fragrances, blended fragrances obtained by blending various natural fragrances and synthetic fragrances.

  Specific examples of perfume ingredients include anis alcohol, anisic acid, p-anisic acid, amidinoproline, amylcinhyaldehyde, amylcinnamyl alcohol, denatonium benzoate, benzyl benzoate, methyl anthranilate, isoeugenol, isopulegol, α -Isomethylionone, undecalactone, ethyldimethylhydrocinnamal, ethyl vanillin, eugenol, γ-caprolactone, allyl caproate, camphor, coumarin, glyoxal, gluconolactone, cinnamon alcohol, cinnamaldehyde, isoamyl cinnamate, cinnamon Ethyl acetate, benzyl cinnamate, geraniol, amyl acetate, isoamyl acetate, isobutyl acetate, isopropyl acetate, isobornyl acetate, ethyl acetate, ethoxyethyl acetate, citronellyl acetate Phenethyl acetate, butyl acetate, propyl acetate, benzyl acetate, linalyl acetate, saccharin, saccharin Na, amyl salicylate, phenyl salicylate, benzyl salicylate, methyl salicylate, diacetone alcohol, citral, citronellal, citronellol, methyl dihydrojasmonate, 2, 6-dimethyl-7-octen-2-ol, dimethylphenylpropanol, tetrahydrobisabolol, terpineol, tromethamine, ethyl lactate, butyl lactate, methyl lactate, menthyl lactate, nonalactone, vanillin, bisabolol, hydroxycitronellal, farnesol, Phytol, phenylpropanol, phenethyl alcohol, butylphenylmethylpropional, butyrolactone, hexadecanolactone, hexa Tilindanopyran, hexylcinnamal, heliotropin, benzyl alcohol, benzaldehyde, pentadecalactone, borneol, methylacetophene, citronellyl methylcrotonate, methyldiisopropylpropionic acid amide, methylphenylglycidylate, methylphenylbutanol, methoxy Propanediol, menthone glycerin acetal, eucalyptol, caprylyl butyrate, raspberry ketone, linalool, limonene, etc. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  Examples of the preservative include benzoic acid and salts thereof, photosensitizers, salicylic acid, N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate, sorbic acid and salts thereof, paraoxybenzoic acid esters, phenoxyethanol and the like. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  Examples of the colorant include organic synthetic dyes (dyes, lakes, organic pigments), natural dyes, inorganic pigments, pearlescent pigments, polymer powders, functional pigments, and the like. These are arbitrarily limited as long as they are in accordance with the purpose and intention of the present invention. Can be used without.

  Moisturizers include plant extracts, animal extracts, natural moisturizing factors (NMF factors), components obtained from animals, plants and seaweeds (proteins, peptides, carbohydrates, polysaccharides, glycoproteins, glycolipids, lipid proteins, etc.) , Polyhydric alcohol (alkylene (20-30) glycol, isoprene glycol, erythritol, glycerin, xylit, xylobiose, diglycerin, dipropylene glycol, sorbitol, 1,3-butylene glycol, propylene glycol, 1,2-hexanediol 1,2-pentanediol, polyethylene glycol, polyoxyethylene glycerin, polyoxyethylene methyl glycoside, polyglycerin, maltitol, mannito, POE methyl glucoside, 3-methyl-1,3-butanediol, etc.) Luo optionally without limitation can be used as long as according to the purpose and intent of the present invention.

  Thickeners include natural polymers (gum arabic, sodium alginate, ethyl cellulose, carrageenan, carboxyvinyl polymer, xanthan gum, guar gum, quince seed, synthetic sodium silicate / magnesium, gellan gum, cyclodextrin, tamarind gum, dextrin fatty acid ester, Starches, tragacanth, hydroxyethyl cellulose, pectin, polyacrylic acid amide, sodium polyacrylate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, locust bean gum, etc. These can be used without any limitation as long as the purpose and intention of the present invention are used.

  Examples of drugs include azelain, aminobright, arbutin, ellagic acid, ascorbic acid and derivatives thereof, panthetin-s-calcium sulfonate, lucinol, vitamin A and derivatives thereof, thiamines, riboflavin and derivatives thereof, pyridoxine and derivatives thereof, cyanocobalamin , Folic acid, inosit, biotin, pantothenic acid and its analogs, pantethine, nicotinic acid, nicotinic acid amide, ergocalciferol, cholecalciferol, vitamin E derivatives, vitamin F, menadione, rutin, methyl hesperidin, adenosine phosphate, ikmotal , Camphor, miconazole nitrate, thymol, polyoxyethylene lauryl ether, menthol azulene, ε-aminocaproic acid, allantoin, entereline-2, lysozyme chloride Guaiazulene and its derivatives, glycyrrhizin and its derivatives, glutathione, saponin, bisabolol, γ-oryzanol, cantalis tincture, ginger tincture, cephalanthin, pepper tincture, benzyl nicotinate, pantothenic acid and its derivatives, hinikithiol, t-flavan, pentadecane Acid glycerides, sulfur, salicylic acid, thioxolone tranexamic acid, BHA (beta hydroxy acid), resorcin, allantoin hydroxyhydroxyaluminum, zinc oxide, aluminum chloride, hydroxyaluminum chloride orthotenyl succinate corn starch ester aluminum, zinc oxide, water Aluminum oxide, zinc paraphenolsulfonate, zinc sulfate, aluminum sulfate, potassium aluminum sulfate, organic acids (citric acid, Haq acid, tartaric acid, tannic acid, lactic acid, etc.), superoxide dismutase, dibutylhydroxytoluene, hydroquinone, phytic acid, butyl hydroxy anisole. These can be used without any limitation as long as the purpose and intention of the present invention are followed.

  The present invention can be applied to cosmetics, quasi drugs, and the like that are effective in preventing skin aging and promoting healing of chronic dermatitis.

Claims (5)

(A) a mammalian placenta extract;
(B) a yeast extract;
(C) human oligopeptide-1 (h-EGF: human epidermal growth factor);
(D) essential oil extracted from plants (essential oil) or steam distilled water (aromatic distilled water);
An external composition for skin, comprising:   The composition for external use according to claim 1, wherein the barrier function repairing agent is placenta extract, yeast extract, or human oligopeptide-1.   The external composition for skin according to claim 1 or 2, wherein any of the anti-inflammatory agent, antioxidant, anti-aging agent and cell activator is essential oil or steam distilled water. The essential oil or steam distilled water is
Aomoji fruit oil, Atlas cedar bark oil, Anise oil, Amyris balsamifera bark oil, Angelica root oil, Italian cypress oil, Ylang-ylang flower oil, Indian lemongrass oil, Fennel fruit oil, Fennel oil, Empizubixin oil, Papilio mandarin peel oil , White palm oil, oil salvia oil, origanum heracreochicum flower oil, olmenis mulcauris oil, orange flower oil, carnation flower oil, cassia leaf oil, gadget root oil, hydrolyzed citrus oil, canaryno resin oil, camomile oil, Cayupute oil, caraway fruit oil, caraway seed oil, koryuba oil, myrtle oil, camphor bark oil, gardenia oil, kumquat oil, grapefruit peel oil, kunzea erikoides leaf oil, cinnamon oil, ghetto leaf oil, kosuigaiya oil, Pepper Fruit oil, coriander fruit oil, cyberas esculenta root oil, sassafras root oil, cicada flower, shisimbrium irio seed oil, cistern daniferus resin, siberian fir oil, muskow, jasmine oil, junibel mexicana Ginger root oil, ginger seed oil, gentian bell casumnal root oil, sweet acacia flower oil, spike lavender oil, spearmint oil, pine bulb oil, pine leaf oil, pearl millet oil Bark oil, sage geranium oil, centifolia rose flower oil dai daiko oil, daiso pepper oil, thyme oil, siamese oil, damask rose oil, thymus mastina oil, tea leaf oil, clove bud oil, clove flower oil, clove leaf oil Clove oil, tea tree leaf oil, German spruce oil, citrus oil, pepper oil, violet oil, oil tempura oil, scented oil, nutmeg kernel oil, sorghum oil, wild rose oil, pine oil, bakushia triodora Leaf oil, lotus flower oil, parsley seed oil, patchouli oil, peppermint leaf oil, peppermint oil, vanilla fruit oil, palmarosa oil, bitter almond kernel oil, bitter orange peel oil, hiba oil, cedar tree oil, himekoji leaf oil, Sandalwood oil, Ferragalgarniflora resin oil, Fusanus spicus wood oil, Petit glen oil, Bay oil, Vetiver root oil, Haematococcus prubiaris oil, Peruvian sam, Bergamot fruit oil, Hokubay fuuroso oil, Boswellia serrata oil, Majorana flower Oil, Majorana leaf oil, Mandarin orange peel oil, Mandarin Orange leaf oil, Mebuki oil, Melaleuca Ericiphoria leaf oil, Melaleuca biridiflora leaf oil, Melissa leaf oil, Moscata rose oil, Vineyard oil, Momijibafu oil, Willow mint leaves oil, Eucalyptus triodora oil, Eucalyptus leaf oil, Eucalyptus oil , Yuzu peel oil, Yuboku oil, European fir leaf oil, European fir oil, lime oil, Laban Dura hybrida oil, Labdanum oil, lavender oil, apple oil, Leptosperm petersonii oil, lemon peel oil, lemongrass oil, Lemon fruit oil, lemon leaf oil, rosewood tree oil, rosemary oil, rose oil, Lawson cypress tree oil, Roman chamomile flower oil, laurel oil,
American Neko tree water, Alpinia uraiensis stalk / leaf water, aloe vera leaf water, fennel water, ume fruit water, edelweiss water, orange fruit water, orange flower water, orange flower water, oro blanco fruit water, citrus root water, chamomile water, Kiwi fruit water, Kuzuzura flower water, grapefruit fruit water, ghetto leaf water, ghetto flowers / leaves / stem water, coconut palm water, rice bran water, cistus sula danifels leaf / stem water, ginger water, white rose fruit water, slow berry flower Water, sudachi water, swan leaf water, pear water, elderflower water, sorghum fruit water, hazel leaf water, sage water, sage leaf water, nematode water, centifolia rose water, aisantiku water, damask rose flower Water, chishimasa water, tea leaf water, camellia flower water, touki water, tomato fruit Water, pineapple fruit water, hybrid rose water, lotus root water, lotus flower water, mint water, pearl seed water, banana flower water, madonna ally water, hamamelis water, hamamelis flower water, mandarin orange water, bitter orange flower water, cypress water , Grape fruit water, Fuyubodaiju flower water, Bodaiju water, Melissa water, Melon fruit water, Cornflower flower water, Eucalyptus water, Yuzu skin water (Yuzu water), Yuzu water, European raspberry fruit water, European birch water, Artemisia water Lychee water, lavender flower water, apple fruit water, high pressure apple fruit juice, lemon fruit water, rose water, rosemary water, ronisera frog elrea fruit water, french lavender water, chrismum maritimum water, helichrysumitarum Water, cistus sperperiensis water,
The external composition for skin according to claim 1, wherein the composition is one or more selected from the group consisting of:   The external composition for skin according to claims 1 to 4, which is effective for preventing skin aging and promoting healing of chronic dermatitis.