CN115671162A - Traditional Chinese medicine preparation for treating atopic dermatitis and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese medicinal preparation for the treatment of atopic dermatitis and its preparation method, its component is 1-100 parts of radix Arnebiae, 1-50 parts of fructus Cnidii, 1-50 parts of licorice, cicada slough 1-30 parts, fructus Cannabis 1-150 parts according to the part by weight, solve the problem of poor curative effect of the like product at present, it is natural plant to have the component, easy to use, safe and effective, advantage such as the quality is reliable, can substitute the biological medicine treatment method of chemical medicine and hormone, avoid its side effect and state of an illness from repeating the phenomenon.

Description

Traditional Chinese medicine preparation for treating atopic dermatitis and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine preparation for treating atopic dermatitis, in particular to a traditional Chinese medicine preparation for treating atopic dermatitis by taking pure traditional Chinese medicines as raw materials and a preparation method of the preparation.

Background

Atopic dermatitis is a chronic, recurrent, inflammatory skin disease. Patients often have severe itching, which seriously affects the quality of life.

The prevalence rate of atopic dermatitis is gradually increased in the past 30 years worldwide, the prevalence rate of the atopic dermatitis of children in developed countries reaches 10% -20%, the prevalence rate of the atopic dermatitis of China is increased later than that of developed countries in western countries, japan and Korea, but the prevalence rate of the atopic dermatitis is rapidly increased in the last 10 years. Epidemiological investigation conducted by Williams diagnostic standards in China in 1998 shows that the total incidence of atopic dermatitis in teenagers (6-20 years old) in school age is 0.70%, the incidence of atopic dermatitis in preschool children (1-7 years old) in 10 cities in 2002 is 2.78%, and the incidence of atopic dermatitis in children 3-6 years old in Shanghai area in 2012 is 8.3%. In 2014, by adopting the diagnosis standard of a clinician, the prevalence rate of the atopic dermatitis of 1-7 year old children in 12 cities in China reaches 12.94%, and the prevalence rate of the atopic dermatitis of infants in 1-12 months reaches 30.48%.

Atopic dermatitis is a intractable disease, which is said to treat diseases but not treat skin. In the current stage, glucocorticoid, antibiotics, antihistamine, biological agents and the like are mostly adopted for treating the disease, and only symptoms can be relieved by the existing treatment means, so that the phenomenon that a plurality of symptoms of atopic dermatitis patients are repeated, that is, the patients are treated with the medicine and are stopped with the medicine is commonly existed, and even adverse reactions are caused; a few traditional Chinese medicine atopic dermatitis treatment schemes have the problem that the treatment effect is not clear.

Disclosure of Invention

The invention aims to solve the problems of unobvious treatment effect, repeated symptoms, more adverse reactions and the like of atopic dermatitis at the present stage, provides a traditional Chinese medicine preparation which comprehensively improves the symptoms, is safe and effective, has no side effect, has reliable quality and the like, and provides a preparation method of the traditional Chinese medicine preparation.

Atopic dermatitis clinically manifests as dry skin, eczema-like skin lesions and obvious itching, and the angle of syndrome differentiation in traditional Chinese medicine belongs to the damp-heat syndrome of nutrient and blood. The long-term retention of damp-heat in the nutrient and blood system may lead to the stagnation of qi, toxicity, dryness and wind, and the normal yin and body fluids may not be spread out, resulting in dry skin, local damage with secretion and severe pruritus. For treatment, yu Qingre is declared, which is used for removing toxicity and promoting diuresis.

The prescription of the technical scheme is composed of fructus cannabis, lithospermum, fructus cnidii, periostracum cicadae and raw liquorice, the compatibility is precise and appropriate, and the curative effect is excellent in early clinical practice. Wherein, the lithospermum is bitter and cold, can cool blood and activate blood, clear away heat and toxic material, can penetrate deep into blood system to disperse and remove damp toxin of blood system, and is a monarch drug; the fructus cnidii is pungent, bitter and warm, has the effects of drying dampness, dispelling wind and relieving itching, is a ministerial drug and an adjuvant drug, and has the property of Xin Wenqu wind that can prevent the radix arnebiae from blocking qi activity due to excessive cold and cold so as to help the blood damp toxin to disperse qi externally, and simultaneously has good effects of drying dampness and relieving itching, and plays a mutual reinforcement and synergism role when being matched with the radix arnebiae; the fructus cannabis oil in fructus cannabis is sweet, neutral and moist, nourishes blood and promotes blood circulation, can reduce yangming stagnated fire and dryness-qi, relieves the dryness and itching of skin, and is a ministerial drug in the prescription; the cicada slough is pungent, sweet and salty in taste, has a flat and slightly cool air, can disperse wind-heat, assists the lithospermum to disperse and remove nutrient-blood damp toxin, and is a ministerial drug; licorice root, radix Glycyrrhizae is sweet in flavor and mild in action, and can remove toxicity, neutralize the action of herbs, and relieve itching. Meanwhile, cicada slough and liquorice have certain antiallergic and anti-immunoreaction effects in modern researches, and are common medicines for clinically treating various types of dermatitis caused by allergy. The prescription proportion in the prescription is increased or decreased according to the corresponding clinical symptoms of patients.

The concrete weight portion proportioning scheme is as follows:

1-100 parts of lithospermum, 1-70 parts of fructus cnidii and 1-70 parts of liquorice

1-30 parts of cicada slough and 1-150 parts of fructus cannabis;

optionally, the components are as follows according to the weight portion:

10-80 parts of lithospermum, 10-60 parts of fructus cnidii and 10-60 parts of liquorice

10-30 parts of cicada slough and 50-130 parts of fructus cannabis.

Optionally, the components are as follows according to the weight portion:

50-70 parts of lithospermum, 30-50 parts of fructus cnidii and 30-50 parts of liquorice

15-25 parts of cicada slough and 80-120 parts of fructus cannabis.

Optionally, the components are as follows according to the weight portion:

gromwell root 60 parts, cnidium fruit 40 parts, licorice root 40 parts

20 parts of cicada slough and 100 parts of fructus cannabis.

The preparation is external preparation, and the specific dosage form comprises plastics, cream, gel, liniment, tincture, gel paste, and patch.

The preparation forming method comprises extracting the Chinese medicinal materials with water or ethanol, adding appropriate adjuvants, and making into topical preparation for convenient use.

The extraction method comprises water extraction, ethanol solution extraction with different concentrations, water extraction and alcohol precipitation method extraction, steam distillation method extraction and supercritical extraction method extraction, and the obtained extract can be prepared into a preparation for patients to exert the drug effect more quickly.

The invention has the beneficial effects that:

1. the Chinese medicinal preparation is prepared according to the theory of traditional Chinese medicine and combined with modern scientific research achievements, has the characteristics of short treatment course and quick response clinically, provides a Chinese medicinal preparation with exact curative effect for common diseases and frequently encountered diseases, and highlights the characteristics of the traditional Chinese medicine.

2. The traditional Chinese medicinal materials in the prescription are scientifically extracted and purified, so that the content of effective components is improved, adverse reactions are not seen in clinical observation of patients with atopic dermatitis, and the purposes of safety, effectiveness and convenient use are achieved.

3. The preparation process of the invention is supported by laboratory data in each step, and the content determination index of the effective component is established, thereby ensuring the product quality.

4. The medicine of the invention increases a powerful weapon for clinical medication with symptoms, and is a new high-efficiency medicine.

Detailed Description

The technical solution of the present invention is further illustrated by the following examples.

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly apparent, the present invention is further described in detail with reference to the embodiments.

Example 1

The invention provides a technical scheme that: a traditional Chinese medicine preparation for treating atopic dermatitis comprises the following components in parts by weight:

50 parts of lithospermum, 30 parts of fructus cnidii and 30 parts of liquorice

30 parts of cicada slough and 120 parts of fructus cannabis.

The preparation process comprises the following steps:

(1) extracting radix Arnebiae, fructus Cnidii, glycyrrhrizae radix, and periostracum Cicadae decoction pieces with ethanol under reflux for 2 times (2 hr each time), filtering, recovering ethanol from filtrate, and concentrating to obtain extract with a material-to-liquid ratio of 1:1, adding ethanol until the ethanol content is 70%, standing overnight, filtering, and collecting the filtrate.

(2) Extracting fructus Cannabis decoction pieces with ethanol under reflux for 4 hr for 2 times, filtering, recovering ethanol from filtrate until there is no ethanol smell, centrifuging, and collecting supernatant.

(3) Dissolving 40g of polyvinyl alcohol in 70% ethanol; adding the above two solutions, adding 20g glycerol, and stirring to obtain topical plastics.

Is applied to patients, has obvious curative effect and does not rebound.

Example 2

The composition comprises the following components in parts by weight:

50 parts of lithospermum, 40 parts of fructus cnidii and 40 parts of liquorice

30 parts of cicada slough and 120 parts of fructus cannabis.

The preparation process comprises the following steps:

(1) reflux-extracting radix Arnebiae, fructus Cnidii, glycyrrhrizae radix, and periostracum Cicadae with purified water for 2 times, each for 1 hr

Filtering, combining the filtrates, concentrating to obtain a clear paste with the relative density of 1.2 to 1.3 at room temperature, adding ethanol until the alcohol content is 50%, standing overnight, filtering, and keeping the filtrate for later use.

(2) Extracting volatile oil from fructus Cannabis decoction pieces by co-water distillation.

(3) Mixing the above two extractive solutions, adding carbomer 974 1% of the total amount of the extractive solutions, swelling, and adding triethyl phosphate

Regulating pH to 6~8 with alcohol amine to obtain topical gel.

Example 3

The composition comprises the following components in parts by weight:

gromwell root 60 parts, cnidium fruit 40 parts, licorice root 40 parts

25 parts of cicada slough and 120 parts of fructus cannabis.

The preparation process comprises the following steps:

(1) reflux-extracting radix Arnebiae, fructus Cnidii, glycyrrhrizae radix, and periostracum Cicadae decoction pieces with 70% ethanol for 2 times, each for 2 hr, filtering, recovering ethanol from filtrate, and concentrating to obtain extract with a material-to-liquid ratio of 1:1, adding ethanol until the ethanol content is 70%, standing overnight, filtering, and collecting the filtrate.

(2) Extracting fructus Cannabis decoction pieces with ethanol under reflux for 4 hr for 2 times, filtering, recovering ethanol from filtrate until there is no ethanol smell, centrifuging, and collecting supernatant.

(4) Mixing appropriate white vaseline and liquid paraffin, adding above two solutions, and adding 20g

And (5) stirring the mixture with glycerol to obtain the external ointment.

Example 4

The composition comprises the following components in parts by weight:

gromwell root 60 parts, cnidium fruit 40 parts, licorice root 40 parts

20 parts of cicada slough and 100 parts of fructus cannabis.

The preparation process comprises the following steps:

adding 10 times of water into the traditional Chinese medicines, decocting for two times, and concentrating the filtrate until the ratio of material to liquid is 1:1, adding a proper penetration enhancer and a cream matrix, and uniformly mixing to obtain the external cream.

The film forming agent in the preparation process comprises hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyethylene glycol and acrylic resin film forming agent; the penetration enhancer comprises alcohols, amides, surfactants, etc.; ointment and cream bases include white petrolatum, liquid paraffin, lanolin, cetyl alcohol, stearyl alcohol, and the like.

The sequence of the above embodiments is only for convenience of description and does not represent the advantages and disadvantages of the embodiments.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (9)

1. A traditional Chinese medicine preparation for treating atopic dermatitis is characterized in that: the composition comprises the following components in parts by weight: 1-100 parts of lithospermum, 1-70 parts of fructus cnidii, 1-70 parts of liquorice, 1-30 parts of periostracum cicadae and 1-150 parts of fructus cannabis.

2. The Chinese medicinal preparation according to claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 10-80 parts of lithospermum, 10-60 parts of fructus cnidii, 10-60 parts of liquorice, 10-30 parts of periostracum cicadae and 50-130 parts of fructus cannabis.

3. The Chinese medicinal preparation according to claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 50-70 parts of lithospermum, 30-50 parts of fructus cnidii, 30-50 parts of liquorice, 15-25 parts of periostracum cicadae and 80-120 parts of fructus cannabis.

4. The Chinese medicinal preparation according to claim 1, which is characterized in that: the composition comprises the following components in parts by weight: 60 parts of lithospermum, 40 parts of fructus cnidii, 40 parts of liquorice, 20 parts of periostracum cicada and 100 parts of fructus cannabis.

5. The Chinese medicinal preparation according to claim 1, which is prepared by the following steps: extracting radix Arnebiae, fructus Cnidii, glycyrrhrizae radix, periostracum Cicadae, and fructus Cannabis with solvent, adding appropriate adjuvant, and making into external preparation.

6. The Chinese medicinal preparation of claim 5, wherein the solvent is one or both of purified water and ethanol.

7. The Chinese medicinal preparation as claimed in claim 5, wherein the extraction method is one or more of water decoction, water extraction and alcohol precipitation, ethanol reflux extraction, cold soaking, co-water distillation and steam distillation.

8. The Chinese medicinal preparation as claimed in claim 5, wherein the dosage form of the external preparation comprises paste, liniment, plastics, gel, cream, gel paste and patch, and the preparation is directly applied to the affected part after being formed.

9. The Chinese medicinal preparation of claim 5, wherein the suitable adjuvant comprises one or more selected from gel matrix, cream matrix, gel ointment matrix, penetration enhancer, pH regulator, hardness regulator, emulsifier, and film-forming agent.