CN115607636A - Traditional Chinese medicine composition for treating obesity and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating obesity and preparation method and application thereof Download PDFInfo
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- CN115607636A CN115607636A CN202211533297.9A CN202211533297A CN115607636A CN 115607636 A CN115607636 A CN 115607636A CN 202211533297 A CN202211533297 A CN 202211533297A CN 115607636 A CN115607636 A CN 115607636A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating obesity, a preparation method and an application thereof, wherein the traditional Chinese medicine composition comprises the following raw materials: corn stigma, coix seed, radish seed, hawthorn, lotus leaf, poria cocos, rhizoma alismatis and phaseolus calcaratus, wherein the traditional Chinese medicine composition comprises a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and damp-heat type or/and a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and damp-heat type, and raw materials of the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and damp-heat type also comprise vinegar-processed rhubarb, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri; the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid pathogen and cold dampness also comprises herba lycopi, semen plantaginis, astragalus membranaceus, bighead atractylodes rhizome, orange peel and rhizoma atractylodis. The invention aims to provide a traditional Chinese medicine composition for treating obesity, a preparation method and application thereof.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating obesity as well as a preparation method and application thereof.
Background
The western medicine considers that: obesity refers to excessive fat accumulation and/or abnormal distribution in the body, and is a common metabolic disease. Body Mass Index (BMI) is commonly used to assess whether obese. Body Mass Index (BMI) = weight (kg)/height (m) squared. If the body constitution index exceeds 24, overweight is determined, if the body constitution index exceeds 28, obesity is determined, if the body constitution index is between 24 and 28, obesity is determined, and the two categories of simple obesity and secondary obesity are determined according to the etiology. The western medicine for weight loss is fenfluramine, but the western medicine for weight loss is forbidden by the nation due to large side effect. Orlistat achieves weight loss by reducing fat absorption, but it can affect the absorption of fat-soluble vitamins, as well as gastrointestinal symptoms such as abdominal pain, diarrhea, anorexia, and even jaundice, which rebound quickly after withdrawal.
The traditional Chinese medicine has a long history of understanding obesity, but the understanding is scattered and no consensus is formed. The etiology considers the factors of constitution, innate endowment, improper diet, good and bad movement, seven emotions staying up all night and the like, the pathogenesis is considered from several aspects of phlegm dampness, stomach heat, spleen deficiency, qi deficiency, blood stasis and the like, and doctors in recent times consider the relation to turbid toxin. Syndrome type classification is eight, different experts have different classifications, more than ten, less than ten, also have several classifications, very messy and complicated, and no unified typing and unified treatment scheme is formed so far. The weight-reducing Chinese patent medicines comprise fat-reducing and weight-reducing tablets, toxin-expelling and fat-reducing capsules, weight-reducing and fat-reducing pills and the like, and the tablets are not a plurality of in variety, but are not classified completely, and mainly take the effects of strengthening spleen and eliminating dampness or removing blood stasis and reducing fat to reduce weight, but do not meet the real pathogenesis of obesity, so the curative effect is not satisfactory. The main reason for this is that the complex pathogenesis of obesity is really unknown and mastered, and the intrinsic nature of the complex constitution of the obese patient is not known and revealed. Therefore, no efficient prescription medicine aiming at the obesity with multi-pathogenesis compound constitution is developed, so that various medicines sold on the market at present have poor curative effect.
Obesity is related to physical constitution, which is well recognized. The inventor carries out deep innovation research, induction and classification on pathogenesis and constitution of the obesity according to the theory of traditional Chinese medicine and summarizes the obesity through long-term clinical practice, so that the obesity is a disease with multiple pathogenesis and compound constitution, and the three types are obtained: (1) The pattern of spleen deficiency with no apparent heat is called spleen deficiency with phlegm-stasis and dampness-heat. The clinical manifestations are as follows: obesity, younger age, good appetite, dry mouth, bitter taste, bad breath, normal or dry stool or constipation or sticky stool, harder abdomen, yellow or greasy tongue coating. Female with small amount of menstruation and dark color; (2) The pattern of spleen deficiency with obvious cold is called spleen deficiency with phlegm-stasis and cold-dampness. The clinical manifestations are as follows: obesity, a large age, general or little diet, drowsiness, lassitude, aversion to moving, worsening of weakness with movement, or even asthma, and normal or loose stools with soft touch on the abdomen. Swollen tongue with teeth marks on the edge, white and greasy or slippery coating. Female with hypomenorrhea or disorder, dark color; (3) The pattern of spleen deficiency with cold-heat is called the pattern of spleen deficiency with phlegm-stasis and dampness-turbidity with mixed cold-heat. The clinical manifestations are as follows: obesity, drowsiness, lack of strength, a desire for appetite, dry mouth, bitter taste in the mouth, loose or normal stools, pale red tongue with teeth marks on the side, yellow greasy or thick greasy coating. Female with a small amount of menstrual blood and dark color.
Analysis of etiology and pathogenesis: the traditional Chinese medicine considers that the spleen governs transportation and transformation and is the source of qi and blood generation and transformation. Spleen deficiency leads to dysfunction of transportation and transformation, resulting in phlegm-dampness accumulation in qi system, blood stasis and turbidity generation in blood system, and accumulation of fat in local area along the meridian and muscles surface, leading to obesity. The spleen qi's function is different, so it is divided into the above three types of multi-pathogenesis composite constitutions. No one has refined and generalize the most basic pathogenesis of the obesity into five pathogenesis types of deficiency of the spleen, dampness, phlegm, stasis and turbidity to form a formula for treatment, and three pathogenesis composite body types are derived according to the difference of mixed cold, heat and cold-heat to construct the formula according to differentiation of symptoms and root causes, so that the problem of treating both principal and secondary aspects of obesity by differentiating body and losing weight is solved.
In view of this, the present invention is proposed.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide the traditional Chinese medicine composition for treating obesity as well as the preparation method and the application thereof.
In order to achieve the purpose, the invention is solved by the following technical scheme:
a traditional Chinese medicine composition for treating obesity comprises the following raw materials: corn stigma, coix seed, radish seed, hawthorn, lotus leaf, poria cocos, rhizoma alismatis and phaseolus calcaratus, wherein the traditional Chinese medicine composition comprises a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and damp-heat type or/and a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and damp-heat type, and raw materials of the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and damp-heat type also comprise vinegar-processed rhubarb, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri; the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid phlegm and cold dampness also comprises herba lycopi, semen plantaginis, astragalus mongholicus, bighead atractylodes rhizome, orange peel and rhizoma atractylodis.
The traditional Chinese medicine composition for treating spleen deficiency phlegm, blood stasis and damp-heat type adiposis is prepared from the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 5-30 parts of radish seed, 10-60 parts of hawthorn, 10-50 parts of poria cocos, 10-60 parts of lotus leaf, 5-50 parts of rhizoma alismatis, 10-60 parts of phaseolus calcaratus, 5-30 parts of rheum officinale processed with vinegar, 10-30 parts of gynostemma pentaphylla, 5-30 parts of mangnolia officinalis, 5-30 parts of semen cassiae, 5-30 parts of oriental wormwood and 10-60 parts of motherwort.
The traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and turbid cold-dampness type adiposis is prepared from the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 10-60 parts of phaseolus calcaratus, 5-30 parts of radish seed, 10-50 parts of poria cocos, 10-50 parts of herba lycopi, 5-50 parts of semen plantaginis, 10-50 parts of astragalus membranaceus, 5-30 parts of bighead atractylodes rhizome, 10-60 parts of hawthorn, 10-60 parts of lotus leaf, 5-50 parts of rhizoma alismatis, 5-30 parts of orange peel and 3-30 parts of rhizoma atractylodis.
The preparation method of the traditional Chinese medicine composition for treating the obesity comprises the following steps:
(1) Weighing corn stigma, semen coicis, semen raphani, hawthorn, poria cocos, lotus leaves, rhizoma alismatis, phaseolus calcaratus, vinegar-processed rheum officinale, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri in parts by weight, drying the obtained raw materials, uniformly mixing, grinding the raw materials into powder, sieving the powder by a 50-100-mesh medical sieve to prepare powder, and sterilizing the powder for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate I;
(2) Weighing corn stigma, semen coicis, phaseolus calcaratus, semen raphani, poria cocos, herba lycopi, semen plantaginis, radix astragali, rhizoma atractylodis macrocephalae, hawthorn, lotus leaf, rhizoma alismatis, orange peel and rhizoma atractylodis according to parts by weight, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh medical sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate II;
(3) Mixing one or two of the intermediates I and II to make into oral preparation.
The oral preparation is tablet, dispersant, soft capsule, granule, pill, dripping pill, gel or oral liquid.
The preparation process of the tablet in the oral preparation is as follows: selecting one or two of the intermediates I and II, adding Gypsum Fibrosum powder, common adjuvants and binder, mixing, granulating, drying, adding lubricant, mixing, grading, and tabletting to obtain tablet; the common auxiliary materials are selected from one or a mixture of more than two of starch, powdered sugar, microcrystalline cellulose, inorganic salts and mannitol; the adhesive is one of distilled water or 30-70% ethanol solution; the lubricant is one of 0.1-1% of magnesium stearate, 0.1-3% of talcum powder or 0.1-0.3% of superfine silica gel powder.
The preparation process of the soft capsule in the oral preparation comprises the following steps: selecting one or two of the intermediates I and II, adding 1-15% of polyethylene glycol, plasticizer, disintegrating agent, curcumin, ferric oxide, wetting agent and suspending agent, mixing, and encapsulating; the plasticizer is selected from glycerol or polyalcohol; the disintegrating agent is one of dry starch or effervescent disintegrating agent; the wetting agent is one of 30-70% ethanol or liquid paraffin; the suspending agent is selected from beeswax, aluminum monostearate or ethyl cellulose.
The application of the traditional Chinese medicine composition for treating the obesity in preparing a medicine for treating the obesity.
The invention has the following beneficial effects:
(1) The invention carries out deep and comprehensive research from the etiology and pathogenesis of the adiposis, creatively proposes the type of dividing the adiposis into three multi-pathogenesis compound constitutions and provides three associated traditional Chinese medicine compositions; the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid turbidity and cold-dampness type, the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid dampness, cold-heat and miscellaneous type, and the patient can select corresponding traditional Chinese medicine compositions according to clinical manifestations of the patient (wherein the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, damp-heat and miscellaneous type is a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid dampness type and a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid dampness type, and the same weight ratio of the medicines is only the maximum ratio of one of the traditional Chinese medicine compositions);
(2) The inventor considers from the perspective of traditional Chinese medicine that the obesity is not only a qi system disease, but also a blood system disease, and is a qi-blood dual disease; phlegm-dampness exists in qi system, turbid stasis exists in blood system, spleen deficiency is the basis, and qi and blood, deficiency and excess, cold and heat are integrated; according to the difference of the spleen deficiency degree, deficiency and excess, cold and heat degrees, the novel classification which accords with the practical clinical operability is carried out, although the classification is few, the generalization is complete, and the practical development and implementation in the future are facilitated; the traditional Chinese medicine composition provided by the invention is reasonable in compatibility, conforms to pathogenesis, combines the pathogenesis of five causes of (spleen deficiency, phlegm, dampness, turbidity and stasis) of obesity with different attributes of cold and heat, and is prepared into a unique special disease prescription; the traditional Chinese medicine composition for treating spleen deficiency phlegm, blood stasis, turbidity and damp-heat type has the effects of clearing heat, eliminating dampness, promoting blood circulation, removing blood stasis, strengthening spleen, eliminating turbidity, reducing fat and losing weight; the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbidity and cold dampness has the effects of tonifying spleen, eliminating dampness, promoting blood circulation, removing blood stasis, dispelling cold, eliminating turbidity, reducing fat and losing weight; the traditional Chinese medicine composition for treating spleen deficiency phlegm stasis dampness turbidity cold-heat mixed type has the effects of tonifying spleen, eliminating dampness, promoting blood circulation, removing blood stasis, dispelling cold, clearing heat, eliminating phlegm and losing weight;
(3) The invention adopts medicinal and edible raw materials, has no side effect, has better treatment effect on the adiposis, can correct the obese constitution, synchronously regulates the body and reduces the weight, does not rebound, is simple and practical, and is convenient to popularize and apply; and the composition is also suitable for obesity in children;
(4) On the basis of ensuring the treatment effect of the original traditional Chinese medicine, the invention provides the preparation methods of the tablets and the soft capsules for the convenience of storage, carrying and taking of patients, can be directly taken by water, is safe and sanitary, is convenient to carry and store, is easy to produce and sell, and changes the situation of fussy taking method of the traditional Chinese medicine preparation.
The traditional Chinese medicine composition comprises the following traditional Chinese medicines in percentage by weight:
gynostemma pentaphylla: bitter, sweet and cold, replenishing qi to invigorate the spleen, eliminating phlegm to arrest cough, clearing away heat and toxic material.
Corn silk: sweet and neutral, induce diuresis to alleviate edema, induce diuresis to alleviate jaundice.
And (2) plantain seed: sweet and slightly cold. Induce diuresis to treat stranguria, excrete dampness to stop diarrhea, clear liver and improve vision, clear lung and resolve phlegm. It can be taken for a long time to reduce weight and resist fatigue.
Hawthorn fruit: sour, sweet and slightly warm. Promote digestion, invigorate stomach, promote qi circulation and remove blood stasis. Remove food and drink, and eliminate internal stagnation. For spleen deficiency with damp-heat, it can promote digestion, remove food stagnation and induce diuresis. Modern pharmacological research shows that the hawthorn has the effects of expanding blood vessels, reducing blood fat, reducing blood pressure, strengthening heart, contracting uterus, resisting bacteria, calming and the like. The fatty acid contained in fructus crataegi can promote fat digestion.
White atractylodes rhizome: pungent and warm, bitter and sweet. Invigorate spleen, replenish qi, dry dampness, induce diuresis, arrest sweating, and prevent abortion. Can be taken for a long time to lighten the body and prolong the life without hunger. Strengthening the spleen and stomach, inducing fever, lassitude in the limbs, no desire to open the eyes, lassitude, sleepiness and poor appetite.
Processing rhubarb with vinegar: the action of purgation is slow, which is mainly to remove food stagnation and resolve blood stasis.
And (2) cassia seed: sweet, bitter, salty and slightly cold. Clear heat and improve vision, moisten intestines and relax bowel. Modern pharmacological research shows that cassia seed has the functions of lowering blood pressure, lowering serum cholesterol, catharsis, resisting bacteria, etc.
And (5) rhizoma atractylodis: pungent, bitter and warm. Dry dampness and invigorate spleen, dispel wind and cold, improve vision. Entering spleen can raise yang, dispel depression, induce sweating and remove dampness. It is contraindicated for patients with fat, body weight and dampness, and those with thin body and excessive fire.
Small red beans: sweet, sour and neutral. Induce diuresis to alleviate edema, remove toxicity and drain pus, descend to dissipate blood and induce diuresis, and descend to abdominal fullness.
Orange peel: bitter, pungent and warm. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. It is indicated for the accumulation of phlegm and heat in chest.
Herba lycopi: bitter, pungent and slightly warm. Promoting blood circulation, removing blood stasis, inducing diuresis and relieving edema. Herba lycopi can remove blood system and resolve edema, and is a special medicine for treating hematopoiesis into water.
Rhizoma alismatis: sweet and cold in nature. It has the functions of promoting urination, clearing away damp-heat and promoting phlegm and fluid retention. Modern pharmacological research shows that the rhizoma alismatis has the effects of reducing blood fat, resisting fatty liver, expanding coronary artery, reducing blood sugar and the like.
Herba artemisiae scopariae: bitter, pungent and slightly cold. Clear damp-heat and alleviate jaundice. Can be taken for a long time to reduce weight, benefit qi and resist aging. Bland taste and diuresis, it is a special herb for damp-heat in spleen and stomach. The essential herbs for removing dampness and dissipating heat are also called as dampness-removing and heat-dissipating herbs. Modern pharmacological research shows that the oriental wormwood has the effects of benefiting gallbladder, protecting liver, reducing blood fat, expanding coronary artery, reducing blood pressure, relieving fever, killing ascaris, resisting dermatophyte and the like.
Tuckahoe, poria cocos: sweet, bland and neutral. Induce diuresis and drain dampness, invigorate spleen and calm heart. Herbs for inducing diuresis and removing dampness.
Magnolia officinalis: bitter, pungent and warm. Dry dampness and resolve phlegm, descend qi and remove fullness.
Radish seed: pungent, sweet and neutral. Promote digestion, remove distention, direct qi downward and resolve phlegm.
Lotus leaf: bitter and neutral. Clear summer-heat, raise the head and clear yang, cool blood and stop bleeding. Ascending yang qi can disperse blood stasis and retain blood. Modern pharmacological research shows that the lotus leaves have the effects of expanding blood vessels, relieving spasm, reducing blood pressure, reducing blood fat and the like.
Motherwort: bitter, pungent and slightly cold. Promoting blood circulation to regulate menstruation, inducing diuresis to alleviate edema. Promoting blood circulation and nourishing blood, promoting blood circulation without damaging new blood, nourishing blood without stagnating blood stasis, and it is also a holy medicine of Hei Jia.
Astragalus root: sweet and warm. Tonify qi, strengthen superficies, induce diuresis, expel pus, heal wound and promote tissue regeneration. It is good at treating weakness of spleen and stomach.
The coix seed is sweet, light and cool. To invigorate the spleen, remove dampness, remove arthralgia, check diarrhea, clear heat and expel pus. Long-term taking can lighten the body and tonify qi. Benefiting intestines and stomach, and eliminating edema. The coix seed has wide water draining and swelling.
Detailed Description
The present invention will be further illustrated with reference to the following examples.
The embodiment is as follows:
a traditional Chinese medicine composition for treating obesity comprises the following raw materials: corn stigma, semen coicis, semen raphani, hawthorn, lotus leaves, poria cocos, rhizoma alismatis and phaseolus calcaratus, wherein the traditional Chinese medicine composition comprises a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid dampness type, a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid cold and dampness type, or a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid cold and heat mixed type, and the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid dampness type is prepared from vinegar-processed rheum officinale, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri; the Chinese medicinal composition for treating spleen deficiency, phlegm stasis, turbid cold and dampness also comprises herba Lycopi, semen plantaginis, radix astragali, atractylodis rhizoma, pericarpium Citri Tangerinae and rhizoma Atractylodis; the traditional Chinese medicine composition for treating spleen deficiency phlegm-stasis dampness-turbidity cold-heat mixed type also comprises the following raw materials: rhubarb processed with vinegar, fiveleaf gynostemma herb, officinal magnolia bark, cassia seed, virgate wormwood herb, motherwort herb, hiraute shiny bugleweed herb, plantain seed, membranous milkvetch root, largehead atractylodes rhizome, tangerine peel and swordlike atractylodes rhizome.
The traditional Chinese medicine composition for treating spleen deficiency phlegm stasis turbid dampness-heat type adiposis is prepared from the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 5-30 parts of radish seed, 10-60 parts of hawthorn, 10-50 parts of poria cocos, 10-60 parts of lotus leaf, 5-50 parts of rhizoma alismatis, 10-60 parts of phaseolus calcaratus, 5-30 parts of rheum officinale processed with vinegar, 10-30 parts of gynostemma pentaphylla, 5-30 parts of mangnolia officinalis, 5-30 parts of semen cassiae, 5-30 parts of oriental wormwood and 10-60 parts of motherwort. The traditional Chinese medicine composition for treating spleen deficiency phlegm stasis turbid cold dampness type obesity comprises the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 10-60 parts of phaseolus calcaratus, 5-30 parts of radish seed, 10-50 parts of poria cocos, 10-50 parts of herba lycopi, 5-50 parts of semen plantaginis, 10-50 parts of astragalus membranaceus, 5-30 parts of bighead atractylodes rhizome, 10-60 parts of hawthorn, 10-60 parts of lotus leaf, 5-50 parts of rhizoma alismatis, 5-30 parts of orange peel and 3-30 parts of rhizoma atractylodis. The traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, damp turbidity, cold and heat mixed type adiposis consists of the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 5-30 parts of radish seed, 10-60 parts of hawthorn, 10-60 parts of lotus leaf, 10-50 parts of poria cocos, 5-50 parts of rhizoma alismatis, 10-60 parts of phaseolus calcaratus, 5-30 parts of vinegar-processed rhubarb, 10-30 parts of gynostemma pentaphylla, 5-30 parts of mangnolia officinalis, 5-30 parts of semen cassiae, 5-30 parts of oriental wormwood, 10-60 parts of motherwort, 10-50 parts of herba lycopi, 5-50 parts of semen plantaginis, 10-50 parts of astragalus membranaceus, 5-30 parts of bighead atractylodes rhizome, 5-30 parts of orange peel and 3-30 parts of rhizoma atractylodis. The patient can select the corresponding traditional Chinese medicine composition to prepare the traditional Chinese medicine according to the clinical manifestations of the patient.
The preparation method of the traditional Chinese medicine composition for treating adiposis comprises the following steps:
(1) Weighing corn stigma, semen coicis, semen raphani, hawthorn, poria cocos, lotus leaves, rhizoma alismatis, phaseolus calcaratus, vinegar-processed rheum officinale, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri in parts by weight, drying the obtained raw materials, uniformly mixing, grinding the raw materials into powder, sieving the powder by a 50-100-mesh medical sieve to prepare powder, and sterilizing the powder for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate I;
(2) Weighing corn stigma, semen coicis, phaseolus calcaratus, semen raphani, poria cocos, herba lycopi, semen plantaginis, radix astragali, rhizoma atractylodis macrocephalae, hawthorn, lotus leaf, rhizoma alismatis, orange peel and rhizoma atractylodis according to parts by weight, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving by a 50-100-mesh medical sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate II;
(3) One or two of the intermediates I and II are mixed to prepare an oral preparation, wherein the two kinds of the intermediates are mixed to prepare the traditional Chinese medicine composition for treating the spleen deficiency, phlegm stasis, damp turbidity, cold and heat mixed obesity.
The oral preparation is tablet, dispersant, soft capsule, granule, pill, dripping pill, gel or oral liquid.
The process for preparing tablets for oral administration is as follows: selecting one or two of the intermediates I and II, adding Gypsum Fibrosum powder, common adjuvants and binder, mixing, granulating, drying, adding lubricant, mixing, grading, and tabletting to obtain tablet; the common adjuvants are selected from one or more of starch, sugar powder, microcrystalline cellulose, inorganic salts and mannitol; the adhesive is one of distilled water or 30-70% ethanol solution; the lubricant is one of 0.1-1% of magnesium stearate, 0.1-3% of talcum powder or 0.1-0.3% of superfine silica gel powder.
The preparation process of the soft capsule in the oral preparation comprises the following steps: selecting one or two of the intermediates I and II, adding 1-15% of polyethylene glycol, plasticizer, disintegrating agent, curcumin, ferric oxide, wetting agent and suspending agent, mixing, and encapsulating; the plasticizer is selected from glycerol or polyalcohol; the disintegrating agent is one of dry starch or effervescent disintegrating agent; the wetting agent is one of 30-70% ethanol or liquid paraffin; the suspending agent is selected from beeswax, aluminum monostearate or ethyl cellulose.
On the basis of ensuring the treatment effect of the original traditional Chinese medicine, the preparation method of the tablet and the soft capsule is provided for the convenience of storage, carrying and taking of patients, the tablet and the soft capsule can be directly taken with water, are safe and sanitary, are convenient to carry and store, are easy to produce and sell, and change the situation that the taking method of the traditional Chinese medicine preparation is complicated. The traditional Chinese medicine composition provided by the invention is reasonable in compatibility, conforms to pathogenesis, combines the pathogenesis of five causes of (spleen deficiency, phlegm, dampness, turbidity and stasis) of obesity with different attributes of cold and heat, and is prepared into a unique special disease prescription; the traditional Chinese medicine composition for treating spleen deficiency phlegm, blood stasis, turbidity and damp-heat type has the effects of clearing heat, eliminating dampness, promoting blood circulation, removing blood stasis, strengthening spleen, eliminating turbidity, reducing fat and losing weight; the traditional Chinese medicine composition for treating spleen deficiency phlegm stasis turbidity cold dampness type has the effects of tonifying spleen, eliminating dampness, promoting blood circulation, removing blood stasis, dispelling cold, eliminating turbidity, reducing fat and losing weight; the traditional Chinese medicine composition for treating spleen deficiency phlegm stasis dampness turbidity cold-heat mixed type has the effects of strengthening spleen, eliminating dampness, promoting blood circulation, removing blood stasis, dispelling cold, clearing heat, eliminating phlegm and losing weight; the traditional Chinese medicine composition adopts medicinal and edible raw materials, has no side effect, has a better treatment effect on the obesity, can correct the obesity constitution, synchronously regulates the body and reduces the weight, does not rebound, is simple and practical, and is convenient to popularize and apply; the composition is also suitable for children obesity.
The traditional Chinese medicine composition disclosed by the invention is subjected to clinical efficacy tracking, and the treatment process and the treatment results are as follows:
1. selecting a patient:
900 obese patients were selected and randomized into treatment and control groups based on clinical presentation; wherein 150 cases of spleen deficiency phlegm-stasis turbid dampness-heat type, 150 cases of spleen deficiency phlegm-stasis turbid cold-dampness type and 150 cases of spleen deficiency phlegm-stasis turbid cold-heat mixed type are treated by adopting corresponding traditional Chinese medicine compositions; control group: the remaining 450 patients were given the same number according to different groups and were treated with lipid-lowering and weight-reducing tablets as control.
2. The curative effect standard is as follows: according to the standard for judging the curative effect of the obesity in the clinical research guidelines for treating the obesity by using new traditional Chinese medicines of the Ministry of health, the method is divided into clinical control, obvious effect, effective and ineffective.
3. The treatment course is as follows: three months is a course of treatment.
4. The treatment effect is as follows: the results of a treatment course are observed, and the total effective rate is unified according to the effective results and the results.
5. The curative effect of the treatment group and the control group is compared:
the curative effect of the spleen deficiency phlegm-blood stasis turbid dampness-heat type is compared with that of a control group:
| comparison group | Clinical control | Show effect | Is effective | Nullification | Total effective rate |
| Treatment group | 131 | 19 | 2 | 0 | 100% |
| Control group | 10 | 19 | 70 | 51 | 66% |
(II) comparing the spleen deficiency phlegm-stasis turbid cold-dampness type with the curative effect of a control group:
| comparison group | Clinical control | Show effect | Is effective | Nullification | Total effective rate |
| Treatment group | 120 | 21 | 9 | 0 | 100 |
| Control group | 5 | 13 | 43 | 89 | 40.67% |
(III) comparing the curative effects of the spleen deficiency, phlegm stasis, dampness turbidity, cold and heat mixed type and the control group:
| comparison group | Clinical control | Show effect | Is effective | Nullification | Total effective rate |
| Treatment group | 115 | 24 | 11 | 0 | 100% |
| Control group | 7 | 39 | 42 | 62 | 58.67% |
6. The continued treatment results after one treatment course of the control group is invalid:
after one treatment course, the control group had a total of 202 patients who were not effective and who were subsequently treated with the full treatment regimen. After another treatment course (3 months), the results are: 141 cases (69.8 percent) of clinical control, 48 cases (23.76 percent) of significant effect, 13 cases (6.44 percent) of effective effect, 0 case and 100 percent of total effective rate.
Application example 1.
Wexx, male, 35 years old, employee. The patient has a 5-year medical history of obesity, and the patient smokes and drinks plain, and almost takes the night every day. In nearly two months, the physician can feel abdominal distension, bitter taste and dry mouth, sticky and smelly stool, and can make a doctor at his station. 172cm in height, 82kg in weight, distended abdomen and hard to touch. After the spleen deficiency phlegm-stasis turbid dampness-heat type traditional Chinese medicine composition is given, the abdominal distension is obviously improved after the compound diagnosis after 2 weeks, and the body weight is reduced to 75kg. After two months, the body weight was reduced to 67kg and the symptoms disappeared.
Example 2 was applied.
ZhuXX, female, 25 years old, university post graduate. The patient starts to be obese due to the fact that western medicines (specific medicines are not detailed) are taken for anxiety disorder two years ago, and the weight is still increased after the patient stops taking the medicine, so that the patient can see a doctor from a station with the height of 162cm and the weight of 70kg, and the weight of the patient is reduced to 56kg after two and a half months after the patient is given the spleen deficiency, phlegm stasis, damp turbidity, cold and heat mixed traditional Chinese medicine composition.
Example 3 was applied.
Horse XX, male, 38 years old, employee. The patient is obese for three years, has large abdomen and face, is hypodynamia and loose stool, and has the height of 171cm and the weight of 73kg. Is applied to the treatment of spleen deficiency, phlegm stasis and cold dampness type traditional Chinese medicine composition. After two weeks, the weak disappears, the stool is normal, the abdomen is big, the face is obviously improved, and the body weight is reduced to 65kg.
The above description is provided for the purpose of describing the preferred embodiments of the present invention in more detail, and it should not be construed that the embodiments of the present invention are limited to the description above, and it will be apparent to those skilled in the art that the present invention can be implemented in many different forms without departing from the spirit and scope of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for treating obesity is characterized by comprising the following raw materials: corn stigma, semen coicis, semen raphani, hawthorn, lotus leaves, poria cocos, rhizoma alismatis and phaseolus calcaratus, wherein the traditional Chinese medicine composition comprises a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and dampness or/and a traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and turbid cold and dampness, and the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis and turbid dampness further comprises rheum officinale, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri which are processed with vinegar; the traditional Chinese medicine composition for treating spleen deficiency, phlegm stasis, turbid pathogen and cold dampness also comprises herba lycopi, semen plantaginis, astragalus membranaceus, bighead atractylodes rhizome, orange peel and rhizoma atractylodis.
2. The traditional Chinese medicine composition for treating obesity according to claim 1, wherein the composition comprises the following components: the traditional Chinese medicine composition for treating spleen deficiency phlegm stasis turbid dampness-heat type obesity comprises the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 5-30 parts of radish seed, 10-60 parts of hawthorn, 10-50 parts of poria cocos, 10-60 parts of lotus leaf, 5-50 parts of rhizoma alismatis, 10-60 parts of phaseolus calcaratus, 5-30 parts of vinegar-processed rheum officinale, 10-30 parts of gynostemma pentaphylla, 5-30 parts of mangnolia officinalis, 5-30 parts of semen cassiae, 5-30 parts of herba artemisiae capillaris and 10-60 parts of motherwort.
3. The Chinese medicinal composition for treating obesity according to any one of claims 1 or 2, wherein: the traditional Chinese medicine composition for treating spleen deficiency phlegm stasis turbid cold dampness type obesity comprises the following raw materials in parts by weight: 10-60 parts of corn stigma, 10-60 parts of coix seed, 10-60 parts of phaseolus calcaratus, 5-30 parts of radish seed, 10-50 parts of poria cocos, 10-50 parts of herba lycopi, 5-50 parts of semen plantaginis, 10-50 parts of astragalus membranaceus, 5-30 parts of bighead atractylodes rhizome, 10-60 parts of hawthorn, 10-60 parts of lotus leaf, 5-50 parts of rhizoma alismatis, 5-30 parts of orange peel and 3-30 parts of rhizoma atractylodis.
4. A method for preparing the traditional Chinese medicine composition for treating obesity according to claim 1, comprising the following steps:
weighing corn stigma, semen coicis, semen raphani, hawthorn, poria cocos, lotus leaves, rhizoma alismatis, phaseolus calcaratus, vinegar-processed rheum officinale, gynostemma pentaphylla, mangnolia officinalis, semen cassiae, herba artemisiae scopariae and herba leonuri in parts by weight, drying the obtained raw materials, uniformly mixing, grinding the raw materials into powder, sieving the powder by a 50-100-mesh medical sieve to prepare powder, and sterilizing the powder for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate I;
weighing corn stigma, semen coicis, phaseolus calcaratus, semen raphani, poria cocos, herba lycopi, semen plantaginis, astragalus membranaceus, bighead atractylodes rhizome, hawthorn, lotus leaves, rhizoma alismatis, orange peel and rhizoma atractylodis according to parts by weight, drying the obtained raw materials, uniformly mixing, grinding into powder, sieving with a 50-100-mesh drug test sieve to prepare traditional Chinese medicine powder, and sterilizing for 8 hours under an ultraviolet germicidal lamp to obtain an intermediate II;
(3) Mixing one or two of the intermediates I and II to make into oral preparation.
5. The preparation method of the traditional Chinese medicine composition for treating obesity according to claim 4, characterized in that: the oral preparation is tablet, dispersant, soft capsule, granule, pill, dripping pill, gel or oral liquid.
6. The method for preparing the traditional Chinese medicine composition for treating obesity according to claim 5, wherein the preparation process of the tablet in the oral preparation is as follows: selecting one or two of the intermediates I and II, adding Gypsum Fibrosum powder, common adjuvants and binder, mixing, granulating, drying, adding lubricant, mixing, grading, and tabletting to obtain tablet; the common auxiliary materials are selected from one or a mixture of more than two of starch, powdered sugar, microcrystalline cellulose, inorganic salts and mannitol; the adhesive is one of distilled water or 30-70% ethanol solution; the lubricant is one of 0.1-1% of magnesium stearate, 0.1-3% of talcum powder or 0.1-0.3% of superfine silica gel powder.
7. The method for preparing a Chinese medicinal composition for treating obesity according to claim 5, wherein the preparation process of the soft capsule in the oral preparation is as follows: selecting one or two of the intermediates I and II, adding 1-15% of polyethylene glycol, plasticizer, disintegrant, curcumin, ferric oxide, wetting agent and suspending agent, mixing, and encapsulating; the plasticizer is selected from glycerol or polyalcohol; the disintegrating agent is one of dry starch or effervescent disintegrating agent; the wetting agent is one of 30-70% ethanol or liquid paraffin; the suspending agent is selected from one of beeswax, aluminum monostearate or ethyl cellulose.
8. The use of the composition of claim 1 for the manufacture of a medicament for the treatment of obesity.
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