CN115462769A - Noninvasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio, heart sound and cardiac function and data calculation method thereof - Google Patents
Noninvasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio, heart sound and cardiac function and data calculation method thereof Download PDFInfo
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Abstract
The invention discloses a noninvasive continuous real-time integrated device for blood pressure, hemodynamics and electrocardio-heart sound and heart functions and a data calculation method thereof. The invention has the beneficial effects that: the device combines heart sound electrocardio with a noninvasive hemodynamic acquisition device, and the obtained blood pressure parameters are mutually calibrated, so that the device not only solves the problem of real-time continuous blood pressure and hemodynamic detection, but also synchronously outputs parameters such as electrocardio parameters, heart sound logarithm, cardiac output, stroke volume, vascular resistance, cardiac contractility and the like.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a noninvasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio-cardiac sound and cardiac function.
Background
Blood pressure is one of important physiological parameters, electronic blood pressure meters are roughly divided into two categories of upper arm type and wrist type according to different measurement positions, which are based on an oscillometric method, an inflation pump is used for inflating and deflating to complete a measurement process, real-time continuous measurement of blood pressure in each stroke cannot be realized, and the electronic blood pressure meters belong to intermittent blood pressure.
Before the blood pressure changes, the hemodynamic parameters such as cardiac output, stroke volume, vascular resistance, cardiac contractility and the like have changed, the blood pressure change is predicted in advance on the aspect of clinical monitoring, and the clinical accident is reduced; the cardiovascular state condition can be evaluated in health management, whether the regulation capability of blood vessels is reduced or not can be evaluated, whether measures are taken as soon as possible to prevent the blood pressure from rising, and the hemodynamic parameters such as cardiac output (cardiac output), vascular resistance, cardiac contractility, heart rate and the like are also important reasons for inducing the blood pressure change; the combination of the electrocardio and the heart sounds can more comprehensively detect whether the heart function and the electrophysiology are normal; at present, noninvasive real-time arterial blood pressure, hemodynamics and electrocardio-cardiac sound synchronous homologous intelligent digital detection is a blank, and therefore a noninvasive continuous real-time blood pressure, hemodynamics and electrocardio-cardiac sound and cardiac function integrated device is provided to solve the technical problems.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a noninvasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio, heart sound and heart functions and a data calculation method thereof.
The purpose of the invention is realized by the following technical scheme:
a noninvasive continuous real-time integrated device for blood pressure, hemodynamics and electrocardio-cardiac sound cardiac functions comprises a signal acquisition module, a statistics and weighting calculation module, a communication module and a display module which are electrically connected with a main control board, wherein the signal acquisition module comprises an electrocardio-cardiac sound digital detection module and a real-time continuous blood pressure and hemodynamics calculation module.
According to a further technical scheme, the electrocardio-heart sound digital detection module comprises an electrocardio-heart sound acquisition module and an electrocardio-heart sound comprehensive processing module, the electrocardio-heart sound acquisition module comprises an electrocardio-heart sound acquisition module, a heart sound acquisition module and a heart rate acquisition module, and the electrocardio-heart sound comprehensive processing module comprises a filter circuit, an electrocardiosignal baseline stabilizing circuit, a signal amplifying circuit, a calculation chip and an AD conversion circuit.
According to a further technical scheme, the real-time continuous blood pressure hemodynamics calculation module comprises a radial artery pressure wave analysis module and a parameter diagnosis module, wherein the radial artery pressure wave analysis module comprises a pressure waveform feature extraction module, a pressure waveform feature amplification module, a pressure waveform feature calculation module and a pressure calculation module.
The further technical scheme is that the blood pressure calculation module and the pressure calculation module are connected with the input end of the statistics and weighting calculation module.
According to a further technical scheme, the electrocardiosignal acquisition module comprises a wrist-lead electrocardiosignal acquisition module and a chest electrocardiosignal acquisition module.
According to a further technical scheme, the electrocardiosignal acquisition module further comprises a limb electrocardiosignal acquisition module.
A data calculation method of a noninvasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio, heart sound and heart function comprises the following steps:
step 3, calculating data according to the features extracted in the step 2;
step 4, calculating real-time continuous blood pressure of the blood pressure data according to a blood pressure regression model;
and 5, calibrating and weighting the continuous blood pressure data obtained in the step 4 and the blood pressure data obtained by the real-time continuous blood pressure hemodynamics calculation module, displaying the weighted real-time continuous blood pressure by the display module, and directly displaying other data which does not relate to blood pressure calculation in the step 4 by the display module after calculation.
Compared with the prior art, the invention has the beneficial effects that:
1. the device combines the heart sound electrocardio and the noninvasive hemodynamic acquisition device, and blood pressure parameters obtained after the measurement and calculation are respectively calibrated, so that the blood pressure output data is more accurate.
Drawings
FIG. 1 is a flow chart of the present invention.
FIG. 2 is a block diagram of the functional module structure of the present invention.
Fig. 3 is an architectural diagram of the present invention.
Fig. 4 is a schematic diagram of a radial artery pressure waveform, phonocardiogram and electrocardiogram.
Fig. 5 is an enlarged view of the radial artery pressure waveform of the present invention.
FIG. 6 is an enlarged schematic view of a phonocardiogram and an electrocardiogram according to the present invention.
FIG. 7 is a schematic diagram of the electrocardiographic heart sound positioning measurement of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
In addition, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, or orientations or positional relationships that the products of the present invention conventionally lay out when in use, or orientations or positional relationships that are conventionally understood by those skilled in the art, which are merely for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1:
referring to fig. 1-7, a non-invasive continuous real-time integrated device for blood pressure, hemodynamics and heart functions of electrocardiograph and heart sounds is provided, which is fitted on a monitor or a wearable device and comprises a signal acquisition module, a statistical and weighting calculation module, a communication module and a display module, wherein the signal acquisition module is electrically connected with a main control panel, the signal acquisition module comprises an electrocardiograph and heart sound digitization detection module and a real-time continuous blood pressure and hemodynamics calculation module, and the electrocardiograph and heart sound digitization detection module, the signal acquisition module and the real-time continuous blood pressure and hemodynamics calculation module are all connected with the main control panel.
The electrocardio-heart sound detection module collects electrocardiosignals and simultaneously collects homologous heart sound signals and converts the homologous heart sound signals into digital signals, and the blood pressure and blood flow dynamics calculation module collects pressure waves of a radial artery flat tension method. One of the collected electrocardiosignals is collected at the wrist part, and the other is collected at the chest part; and calculating real-time continuous blood pressure, cardiac output, cardiac contractility and other hemodynamic parameters according to the pressure wave of the flat tension method.
The communication module can adopt a wired communication or wireless communication module, and is used for transmitting the acquired electrocardio-heart sound signals and the calculation result to an equipment end or an application end through a data line or a wireless module, and the display module is used for displaying the acquired electrocardio-heart sound signals and the parameters in the equipment.
The electrocardio-heart sound digital detection module comprises an electrocardio-heart sound acquisition module and an electrocardio-heart sound comprehensive processing module, the electrocardio-heart sound acquisition module comprises an electrocardio-heart sound acquisition module, a heart sound acquisition module and a heart rate acquisition module, the electrocardio-heart sound comprehensive processing module comprises a filter circuit, an electrocardio-signal baseline stabilizing circuit, a signal amplifying circuit, a calculation chip and an AD conversion circuit, and the electrocardio-heart sound comprehensive processing module is used for filtering clutter, stabilizing baseline, calculating independent electrocardio parameters and independent heart sound parameters and parameters between the electrocardio and the heart sound and carrying out AD conversion processing on the acquired electrocardio and homologous heart sound signals.
The electrocardio acquisition module comprises a wrist-lead electrocardio signal acquisition module and a chest electrocardio signal acquisition module, and further comprises a limb electrocardio signal acquisition module, namely, the electrocardio signal and the heart sound signal acquisition of the chest: the electrocardio acquisition module and the heart sound acquisition module synchronously acquire electrocardio and heart sound signals and display the electrocardio and heart sound signals on the terminal equipment; the electrocardio and heart sound collecting and sensing parts can be overlapped on the same position of the chest and can also be divided into different positions.
The radial artery pressure wave acquisition can also simultaneously acquire electrocardiosignals of the wrist: the pressure sensor is positioned right above the radial artery to collect pressure waveforms, and if wrist electrocardio collection is available, the position for collecting the electrocardio and the pressure sensor on the radial artery are staggered or specially processed to be overlapped.
The chest electrocardio signal acquisition module and the heart sound acquisition module can be used for separate acquisition, and can also adopt an integrated electrocardio and heart sound synchronous acquisition energy gathering head, the electrocardio and heart sound synchronous acquisition energy gathering head structure is disclosed in a novel multifunctional energy gathering head disclosed in the patent publication No. CN208509235U, an electrocardio and heart sound synchronous detection module acquires electrocardiosignals of the chest and simultaneously acquires homologous heart sound signals and converts the homologous heart sound signals into digital signals, the working principle of the electrocardio and heart sound synchronous acquisition is that an electrode conduit replaces the V2 lead position in the existing 12-lead electrocardiogram, a vibration film and a probe are arranged in the electrode conduit, the probe is positioned on the vibration film, when the electrode conduit is attached to the V2 lead position, the vibration of the vibration film can monitor the heart sound, the probe can monitor the electrocardio signals as an electrode, the two signals simultaneously occur and are simultaneously conducted to a main control panel for processing and then displayed on a display terminal, so that the purpose of the electrocardio and heart sound synchronous acquisition is realized.
The real-time continuous blood pressure hemodynamic computing module comprises a radial artery pressure wave analyzing module and a parameter diagnosing module, wherein the parameter diagnosing module can compute hemodynamic parameters such as real-time continuous blood pressure, cardiac output, cardiac contractility and the like, the radial artery pressure wave analyzing module comprises a pressure waveform feature extracting module, a pressure waveform feature amplifying module, a pressure waveform feature computing module and a pressure computing module, and the pressure computing module is mainly used for computing systolic pressure and diastolic pressure blood pressure or cardiac output per beat.
The real-time continuous blood pressure hemodynamic calculation module acquires pressure waves of a radial artery according to a flat tension method, and then calculates hemodynamic parameters such as real-time continuous blood pressure or cardiac output according to the pressure waves of the flat tension method; the analysis module of the radial artery pressure wave of the flat tension method is used for carrying out feature extraction, amplification and calculation on the acquired pressure waveform; the real-time continuous blood pressure or cardiac output and other hemodynamic parameter diagnosis module is used for diagnosing the calculated systolic pressure and diastolic pressure per stroke, the cardiac output and the cardiac contractility.
The electrocardio-heart sound comprehensive processing module and the parameter diagnosis module are both connected with the input end of the statistical and weighted calculation module, the output end of the weighted calculation module is electrically connected with the communication module, the communication module is electrically connected with the display module, namely, the electrocardio-heart sound real-time continuous blood pressure is obtained after the electrocardio-heart sound comprehensive processing module processes, the radial artery pressure signal obtains the radial artery real-time continuous blood pressure after the characteristic extraction and the data calculation, the blood pressures of the electrocardio-heart sound comprehensive processing module and the radial artery pressure signal obtain a weighted real-time continuous blood pressure value after the statistical and weighted calculation module performs weighted calculation, the real-time continuous blood pressure value is a finally obtained blood pressure value, meanwhile, the electrocardio-heart sound signal and the radial artery pressure wave signal not only obtain parameters for calculating the blood pressure, but also obtain other parameters for reflecting the electrocardio-heart sound and the hemodynamics after the data processing, and the parameters can be directly transmitted to the display module for displaying after the data processing.
The display module is used for displaying the acquired electrocardio-heart sound signals and parameters in the equipment, and the wired or wireless communication module is used for transmitting the acquired electrocardio-heart sound signals and the calculation results to the equipment end or the application end through the type-c or wireless module.
A data calculation method of a noninvasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio, heart sound and cardiac function comprises the following steps:
acquiring electrocardiosignals, wherein the acquisition of the electrocardiosignals at least comprises chest electrocardiosignal acquisition and wrist one-lead electrocardiosignal acquisition, and then extracting the highest point of an R wave group, RR interval time and the like in the electrocardiosignals as electrocardiosignal characteristics according to the acquired electrocardiosignals; collecting heart sound signals, wherein the heart sound signals are generally collected in a tricuspid valve auscultation area, and then extracting characteristic waves such as a first heart sound S1 peak value, a second heart sound peak value S2, an R wave group, a P wave group and the like as signal characteristics; and (3) collecting pressure waves of the radial artery, namely collecting pressure waveforms by the pressure sensor positioned right above the radial artery, and extracting a peak point, a dicrotic wave point, a central depression isthmus point and a valley point of the pressure waveforms as signal characteristics.
For electrocardiosignals, estimating the time required by PEP in the prophase of ejection according to RR interval time, the time RWPTT from the highest point of an R wave group to the starting point u of the rapid ejection period of a pressure waveform, the time RWPWIT from the highest point of the R wave group to the peak point M1 of a first heart sound S1, and finally calculating the time difference PWTT1 value through a formula PWTT1= RWPTT-RWPWIT; and meanwhile, calculating the heart rate HR1 according to the peak interval of the R wave group obtained in the step.
And calculating the time difference to calculate the value of the pulse transmission time PWTT2 according to the second heart sound S2 peak point A2 In the heart sound signal and the pressure waveform dicrotic wave point In, and calculating the heart rate HR2 value according to the interval of the main wave peak points of the pressure waveform obtained In the steps. Respectively calculating PWTT1, PWTT2, HR1 and HR2, calculating real-time continuous blood pressure according to a blood pressure regression model, mutually calibrating the calculated real-time continuous blood pressure value with a blood pressure value measured by adopting a blood flow dynamics principle, and processing the real-time continuous blood pressure value and the blood pressure value by adopting a weighting averaging mode if the data of the two values are deviated, wherein the data measured by adopting a flat tension method, namely the blood flow dynamics equipment accounts for 60-90%, the calculated continuous blood pressure value accounts for about 10-40%, and weighting is used for obtaining a real-time continuous blood pressure value.
The parameters except for blood pressure analysis, such as EMAT, EMAT%, LVST%, QRSD, QTD, Q-Td, R-Rv5+ SvI, meanRR, SDNN, RMSSD, CV, systolic pressure (SBP), diastolic pressure (DBP), mean pressure (MAP), heart Rate (HR), continuous Cardiac Output (CCO), isovolumetric systolic index (dP/dt max), systemic Vascular Resistance (SVR), stroke Volume (SV), stroke Volume Variability (SVV), cardiac output power (CPO), cardiac output index (CPI), continuous Cardiac Index (CCI), systemic Vascular Resistance Index (SVRI), stroke Volume Index (SVI), pulse Pressure Variability (PPV) and the like, which are obtained through signal acquisition and feature extraction, are transmitted to a display module for display through a wireless communication module or a wired communication module after being calculated and processed by other parameter data calculation module.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.
Claims (8)
1. The non-invasive continuous real-time integrated device for blood pressure, hemodynamics and electrocardio-cardiac sound and cardiac function is characterized by comprising a signal acquisition module, a statistics and weighting calculation module, a communication module and a display module which are electrically connected with a main control board, wherein the signal acquisition module comprises an electrocardio-cardiac sound digital detection module and a real-time continuous blood pressure and hemodynamics calculation module.
2. The integrated noninvasive, continuous, real-time blood pressure, hemodynamics, electrocardio-cardiac sound and cardiac function device of claim 1, wherein: the electrocardio-heart sound digital detection module comprises an electrocardio-heart sound acquisition module for acquiring electrocardiosignals and heart sound signals and an electrocardio-heart sound comprehensive processing module for processing the acquired electrocardiosignals and the homologous heart sound signals, wherein the electrocardio-heart sound acquisition module comprises an electrocardio-heart acquisition module, a heart sound acquisition module and a heart rate acquisition module, and the electrocardio-heart sound comprehensive processing module comprises a filter circuit, an electrocardio-signal baseline stabilizing circuit, a signal amplifying circuit, a calculation chip and an AD conversion circuit.
3. The integrated noninvasive, continuous, real-time blood pressure, hemodynamics, electrocardio-cardiac sound and cardiac function device of claim 2, wherein: the calculating chip is internally provided with a blood pressure calculating module for calculating blood pressure and an electrocardio-heart sound parameter diagnosing module for diagnosing electrocardio-heart sound parameters.
4. The device of claim 3, wherein the device is further characterized by comprising: the real-time continuous blood pressure hemodynamics calculation module comprises a radial artery pressure wave analysis module and a parameter diagnosis module, wherein the radial artery pressure wave analysis module comprises a pressure waveform feature extraction module, a pressure waveform feature amplification module, a pressure waveform feature calculation module and a pressure calculation module.
5. The device of claim 4, wherein the device is further characterized by comprising: the blood pressure calculation module and the pressure calculation module are both connected with the input end of the statistics and weighting calculation module.
6. The integrated noninvasive, continuous, real-time blood pressure, hemodynamics, electrocardio-cardiac sound and cardiac function device of claim 2, wherein: the electrocardio-acquisition module comprises a wrist-lead electrocardio-signal acquisition module and a chest electrocardio-signal acquisition module.
7. The integrated device of claim 6, which is used for integrated noninvasive, continuous, real-time blood pressure, hemodynamics, electrocardio-heart sound and cardiac function, and comprises: the electrocardio acquisition module also comprises other limb electrocardio signal acquisition modules.
8. The data calculation method of the non-invasive continuous real-time integrated device for blood pressure, hemodynamics, electrocardio-cardiac sound and cardiac function according to claim 1, characterized in that:
step 1, collecting electrocardiosignals, heart sound signals and radial artery pressure waves collected by a signal collecting module;
step 2, extracting characteristics of the electrocardiosignals, the heart sound signals and the radial artery pressure waves collected in the step 1;
step 3, calculating data according to the features extracted in the step 2;
step 4, calculating real-time continuous blood pressure according to the blood pressure regression model for the blood pressure data;
and 5, calibrating and weighting the continuous blood pressure data obtained in the step 4 and the blood pressure data obtained by the real-time continuous blood pressure hemodynamic calculation module, and displaying the weighted real-time continuous blood pressure through a display module, wherein other data which do not relate to blood pressure calculation in the step 4 can be directly displayed through the display module after calculation.
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| CN113729662A (en) * | 2021-09-26 | 2021-12-03 | 东南大学 | Cuff-free wrist watch type blood pressure measuring device integrating electrocardio and heart sound modes |
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| US20050261593A1 (en) * | 2004-05-20 | 2005-11-24 | Zhang Yuan T | Methods for measuring blood pressure with automatic compensations |
| CN108742588A (en) * | 2018-04-12 | 2018-11-06 | 中国医学科学院生物医学工程研究所 | A kind of pulse wave velocity detection method and device |
| CN109512410A (en) * | 2018-12-26 | 2019-03-26 | 东南大学 | A kind of more physiological signal Fusion Features without cuff continuous BP measurement method |
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