CN115444073A - High-fat milk powder for kittens and preparation method and application thereof - Google Patents
High-fat milk powder for kittens and preparation method and application thereof Download PDFInfo
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- CN115444073A CN115444073A CN202211145777.8A CN202211145777A CN115444073A CN 115444073 A CN115444073 A CN 115444073A CN 202211145777 A CN202211145777 A CN 202211145777A CN 115444073 A CN115444073 A CN 115444073A
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- Prior art keywords
- vitamin
- milk powder
- kittens
- fat
- component
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- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940051923 vitamin E 15 mg Drugs 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000021241 α-lactalbumin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
- A23K50/42—Dry feed
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses high-fat milk powder for kittens and a preparation method and application thereof, wherein the high-fat milk powder for the kittens comprises the following components in parts by mass: 20-30 parts of fat component, 15-30 parts of protein component, 35-45 parts of carbohydrate, 1-3 parts of vitamin component and 2-5 parts of mineral component; the fat component is a combination of DHA algal oil powder, medium chain triglyceride, tributyrin, OPO structural lipid and lecithin. The milk powder provided by the invention is based on fatty acid of grease and milk fat of cat breast milk, and according to an ideal fatty acid model of kittens and special effects of functional fatty acid, a fat combination with the most suitable fatty acid composition and structure distribution is prepared, and a specific process technology is adopted for treatment, so that the milk powder becomes multifunctional structural fat which is more beneficial to digestive utilization of kittens, and can relieve the stress reaction of the kittens after weaning and promote the growth of the kittens.
Description
Technical Field
The invention relates to the technical field of animal feeds, and particularly relates to high-fat milk powder for kittens as well as a preparation method and application thereof.
Background
According to the report, the death rate of the pet cats ranges from 50% to 90% from birth to the adult stage. There are many factors responsible for the death of kittens, with insufficient energy intake being one of the most important causes. Fats are rich in essential fatty acids required by animals and are a major source of energy for animals.
CN113349307A provides a pet milk powder, which comprises the following components: the whole camel milk powder, the cordyceps sinensis, the medlar, the amino acid components, the compound vitamins, the compound mineral substances, the protein and the prebiotics, the pet milk powder has the advantages of rich nutrition, easiness in absorption and the like, and cannot become fat after being drunk for a long time, and the protein, fat, vitamin and mineral substance contents in the pet milk powder are higher than those of milk, so that the pet milk powder is beneficial to improving the immunity of animals and is an excellent pet nutrition supplement source.
CN106804877A provides a formula pet milk powder, which is composed of the following components: goat milk powder, whey protein powder, cricket protein powder, lecithin, oligosaccharide, oat puffed powder and gastrodia tuber powder. The formula pet milk powder provided by the invention is reasonable in formula, does not contain any additive, contains lecithin and oligosaccharide, and can ensure that the young pet needs nutrition every day and improve the immune mechanism of the young pet.
Although the prior art discloses the formula milk powder for pets, no special milk powder for kittens is provided, but the requirements of kittens on fat demand and utilization are special, the kittens can well absorb and utilize breast milk fat, but the fat in the milk powder is difficult to digest and utilize, and diarrhea can be caused when the milk powder is fed. The reason for this is, on the one hand, that the digestive system of kittens is not developed well and that the amount of pancreatic lipase and bile secreted by the gastrointestinal tract is not sufficient to completely digest the exogenous fat. On the other hand, the fatty acids in the exogenous fats (soybean oil, phospholipid oil, etc.) exist in the form of POP structure, and the saturated fatty acids are high in content and are not easy to digest and absorb, while the fatty acids in the breast milk mainly exist in the form of OPO structure which is easy to digest and absorb. Therefore, the energy level is a main factor for limiting the growth and development of the kittens. In addition, cats are weaned about 8 weeks after birth, and weaning also causes stress to kittens, which in turn causes diarrhea and affects their growth and health.
Therefore, in order to relieve weaning stress of the kittens and meet the nutritional requirements for growth and development of the kittens, the development of high-fat milk powder with balanced fatty acid and high utilization rate becomes a key point of nutrition research of the kittens.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide high-fat milk powder for kittens and a preparation method and application thereof, wherein the high-fat milk powder for kittens is based on fatty acid of grease and milk fat of kittens, a fat combination with the most suitable fatty acid composition and structure distribution is prepared according to an ideal fatty acid model of the kittens and the special efficacy of functional fatty acid, and a specific process technology is adopted for treatment, so that the fat combination becomes multifunctional structure fat which is more beneficial to digestive utilization of the kittens, and the stress response of the kittens after weaning can be relieved and the growth of the kittens can be promoted.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the high-fat milk powder for the kittens comprises the following components in parts by weight: 20-30 parts of fat component, 15-30 parts of protein component, 35-45 parts of carbohydrate, 1-3 parts of vitamin component and 2-5 parts of mineral component;
the fat component is a combination of DHA algae oil powder, medium chain triglyceride, tributyrin, OPO structural lipid and lecithin.
According to an ideal fatty acid model of the kitten and the special effects of functional fatty acids, the high-fat milk powder provided by the invention enables the fatty acid composition in the final milk powder to be very close to that of the cat breast milk and other nutritional ingredients to be close to the breast milk according to the fatty acid composition of grease and the milk fat of the cat breast milk, so that the requirements of growing development of the kitten on nutrition can be met, the growth of the kitten can be further promoted, the diarrhea rate of the kitten can be reduced, and the stress response of the kitten after weaning can be relieved.
DHA algal oil powder is added into the fat component, so that weaning stress of the kittens can be effectively solved, the milk powder has light fishy smell and good palatability, and feeding of the kittens is promoted; the medium chain triglyceride and the tributyrin can be decomposed into caprylic acid, capric acid and butyric acid under the action of the intestinal pancreatic lipase, the caprylic acid, the capric acid and the butyric acid can rapidly supply energy to organisms, and the medium chain fatty acid has the bacteriostatic action, can adjust intestinal flora, repair intestinal mucosal injury and improve the immunity of the organisms; the OPO structural ester can be hydrolyzed into short-chain saturated fatty acid and unsaturated fatty acid which are better digested, so that the absorption of fat and other nutrient components by the kittens is improved; the fat component of the invention can make the milk powder integrally meet the nutritional requirements of young cats and promote the growth of the young cats through the matching of DHA algae oil powder, medium chain triglyceride, tributyrin, OPO structure fat and lecithin.
In the invention, the addition amount of the fat component in the high-fat milk powder for kittens can be 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts and the like;
the addition amount of the protein component can be 16 parts, 18 parts, 20 parts, 22 parts, 24 parts, 25 parts, 27 parts or 29 parts and the like;
the amount of the carbohydrate to be added may be 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, or the like;
the addition amount of the vitamin component can be 1.2 parts, 1.5 parts, 1.8 parts, 2.0 parts, 2.2 parts, 2.5 parts or 2.8 parts, etc.;
the amount of the mineral component added may be 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, 4.8 parts, or the like.
Preferably, the mass ratio of the DHA algal oil powder, the medium chain triglyceride, the tributyrin, the OPO structural lipid and the lecithin is (4-6): 1.5-2.5): 0.1-0.5): 1.5-3): 0.3-0.5.
Wherein "4-6" can be 4.2, 4.5, 4.8, 5, 5.2, 5.5, or 5.8, etc.;
"1.5-2.5" can be 1.6, 1.8, 2, 2.1, 2.2, 2.3, 2.4, etc.;
"0.1-0.5" can be 0.1, 0.2, 0.3, 0.4, or 0.5, etc.;
"1.5-3" can be 1.6, 1.8, 2, 2.2, 2.4, 2.5, 2.7, 2.9, etc.;
"0.3-0.5" may be 0.32, 0.35, 0.38, 0.4, 0.42, 0.45, 0.48, etc.
Preferably, the protein component comprises any one of whey protein, casein, skim milk powder, skim sheep milk powder or taurine or a combination of at least two of them.
Preferably, the protein component is a combination of whey protein, casein, skim sheep milk powder and taurine.
Casein in the protein component can promote the absorption of metal elements in minerals; the lactalbumin is easy to digest and absorb, contains active substances such as beta-lactoglobulin, alpha-lactalbumin, immunoglobulin and the like, and can improve the immunity of the organism; the defatted goat milk powder contains a large amount of nutrient elements, can promote the development of the body of the young cat, and can improve the immunity; taurine is essential amino acid required by the kitten, can form taurocholic acid with bile acid, and further promotes the digestion and absorption of a body on fatty acid, in addition, taurine is a growth promoting factor of intestinal bifidobacteria, can optimize the intestinal flora structure, and further improves the immunity of the body, and the protein component can improve the absorption and utilization rate of the kitten on protein through the matching of whey protein, casein, defatted goat milk powder and taurine, meets the protein requirement of the kitten on growth, and can enhance the immunity of the kitten.
Preferably, the mass ratio of the whey protein, the casein, the skimmed sheep milk powder and the taurine is (0.5-1): (4-4.5): (5-6.5): (0.1-0.5).
Wherein "0.5-1" can be 0.5, 0.6, 0.7, 0.8, 0.9, or 1, etc.;
"4-4.5" can be 4, 4.1, 4.2, 4.3, 4.4, or 4.5, etc.;
"5-6.5" can be 5.1, 5.3, 5.5, 5.7, 5.9, 6, 6.2, or 6.4, etc.;
"0.1-0.5" may be 0.1, 0.2, 0.3, 0.4, 0.5, etc.
Preferably, the carbohydrate comprises any one of maltose, glucose, lactose, galacto-oligosaccharide or fructo-oligosaccharide or a combination of at least two thereof.
Preferably, the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide.
In the invention, lactose, fructo-oligosaccharide and galacto-oligosaccharide are used as the proliferation factors and nutrient sources of beneficial flora, and can promote the proliferation of beneficial bacteria such as bifidobacterium, lactobacillus and the like in intestinal tracts, thereby improving the immunity and the life vitality of organisms.
Preferably, the mass ratio of the lactose, the galacto-oligosaccharide and the fructo-oligosaccharide is (1-3): (3-4): (0.5-1.5).
Wherein "1-3" can be 1.2, 1.4, 1.5, 1.7, 1.9, 2, 2.2, 2.5, 2.7, 2.9, etc.;
"3-4" can be 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, or 3.9, etc.;
"0.5-1.5" may be 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, etc.
Preferably, the vitamin component comprises vitamin A and vitamin B 2 Vitamin B 6 Vitamin B 12 Vitamin C, vitamin D 3 Vitamin K 3 Any one or the combination of at least two of vitamin E and folic acid,
preferably, the vitamin component comprises 20000-30000IU of vitamin A and vitamin B per kilogram of the vitamin component 2 10-15mg of vitamin B 6 20-30mg of vitamin B 12 0.5-1.5mg, vitamin D5000-10000 IU, vitamin K 3 60-80mg, 10-15mg of vitamin E and 1-5mg of folic acid.
Preferably, the mineral composition comprises any one or at least two of zinc methionine, ferrous gluconate, calcium lactate, manganese methionine, and copper yeast.
Preferably, each kilogram of the mineral component comprises 100-150mg of zinc, 100-200mg of iron, 200-350mg of calcium, 15-20mg of manganese and 30-50mg of copper.
Specific values within the above range can be selected, and are not further described herein.
In a second aspect, the present invention provides a method for preparing high-fat milk powder for kittens as described in the first aspect, the method comprising the steps of:
(1) Mixing and heating part of fat components, then adding carbohydrate and part of protein components, continuously mixing and stirring, adding water after uniform mixing, heating, emulsifying and homogenizing to obtain a mixed solution;
(2) Spray drying the mixed solution to obtain a powdery mixture;
(3) And uniformly mixing the powdery mixture with the rest fat component, the rest protein component, the vitamin component and the mineral component to obtain the high-fat milk powder for the kittens.
The preparation method adopts the preparation process that the protein, the fat and the carbohydrate are emulsified and homogenized firstly, then are prepared into the powdery particles by spray drying, and then are mixed with the vitamin and the mineral components, so that the utilization rate of the high-fat milk powder for the kitten can be greatly improved, and the absorption of various nutritional ingredients of the high-fat milk powder is facilitated, thereby meeting the nutritional requirements of the kitten, improving the survival rate of the kitten and promoting the growth of the kitten.
Preferably, the partial fat component of step (1) is a combination of medium chain triglycerides, tributyrin, OPO structural lipids and lecithin.
Preferably, the mixing in step (1) is heated to 40-45 deg.C, such as 40 deg.C, 41 deg.C, 42 deg.C, 43 deg.C, 44 deg.C or 45 deg.C.
Preferably, part of the protein components in step (1) is a combination of whey protein, casein, and skimmed goat milk powder.
Preferably, the mass ratio of the fat component to water in step (1) is 1 (2-3), and can be, for example, 1.
Preferably, the temperature in step (1) is raised to 70-75 ℃, for example, 70 ℃, 71 ℃, 72 ℃, 73 ℃, 74 ℃ or 75 ℃.
Preferably, the emulsifying and homogenizing time in step (1) is 3-5min, such as 3.2min, 3.5min, 3.8min, 4min, 4.2min, 4.5min or 4.8 min.
Preferably, the particle size of the powdered mixture of step (2) is 0.05-0.1mm, for example 0.05mm, 0.06mm, 0.07mm, 0.08mm, 0.09mm or 0.1mm, etc.
The specific values in the above range can be selected, and are not described in detail herein.
In a third aspect, the present invention provides a cat feed comprising the high-fat milk powder for kittens according to the first aspect.
Compared with the prior art, the invention has the following beneficial effects:
(1) Fat in the high-fat milk powder for the kittens is emulsified and homogenized, so that the high-fat milk powder is more easily digested and absorbed by the kittens, the diarrhea rate can be effectively reduced, the fatty acid composition of the milk powder is very close to that of breast milk according to the fatty acid composition of the grease and the milk fat of the kittens, other nutritional ingredients are also close to the breast milk, and the requirement of growth and development of the kittens on nutrition can be met.
(2) The protein component and the carbohydrate selected in the milk powder can improve the internal environment of intestinal tracts of kittens, improve the immunity of the kittens and promote the kittens to grow quickly.
(3) The milk powder disclosed by the invention is rich in DHA, can effectively solve weaning stress of kittens, can enable the milk powder to have light fishy smell, is good in palatability, and can promote kittens to ingest.
Detailed Description
The technical solution of the present invention is further described below by way of specific embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The information of the materials of the examples and the comparative examples of the present invention is as follows:
DHA algae oil powder is purchased from Qingdao Haizhiyuan Life technologies GmbH;
whey protein was purchased from hebei tuo hai biotechnology limited;
casein was purchased from Zhengzhou Yu and food additives Co., ltd;
the defatted goat milk powder is purchased from Shaanxi Yansen Biotech limited;
taurine, purchased from Yongan pharmaceutical industries, inc. of Xinjiang
Lactose is purchased from grand Runzi Biotech, inc., chengdu;
galactooligosaccharides were purchased from panacea macrobiosciences ltd;
fructo-oligosaccharide was purchased from Honghu Biotech limited;
the other raw materials may be used as long as they are commercially available through a normal channel.
Example 1
The embodiment provides high-fat milk powder for kittens, which comprises the following components in parts by weight of 25 parts of fat component, 20 parts of protein component, 40 parts of carbohydrate, 2 parts of vitamin component and 4 parts of mineral component;
wherein the fat component is a combination of DHA algal oil powder, medium chain triglyceride (caprylic triglyceride), tributyrin, OPO structural lipid and lecithin, the mass ratio of which is 5;
the protein component is a combination of whey protein, casein, skimmed goat milk powder and taurine with the mass ratio of 0.8;
the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide in a mass ratio of 2.5;
the vitamin component comprises 25000IU of vitamin A and vitamin B per kilogram 2 12mg of vitamin B 6 25mg of vitamin B 12 1mg, vitamin D7500 IU, vitamin K 3 70mg, vitamin E12 mg and folic acid 3mg.
The mineral composition comprises 130mg of zinc, 150mg of iron, 300mg of calcium, 18mg of manganese and 40mg of copper per kilogram.
The preparation method of the high-fat milk powder for the kitten comprises the following steps:
(1) Mixing medium chain triglyceride, tributyrin, OPO structural lipid and lecithin, heating to 42 deg.C, adding carbohydrate, lactalbumin, casein and defatted sheep milk powder, stirring, adding 62.5 parts of water, heating the mixture to 75 deg.C, and homogenizing for 4min;
(2) Spray drying to obtain powder mixture with particle diameter of 0.07 mm;
(3) And uniformly mixing the powdery mixture with DHA algae oil powder, taurine, vitamin components and mineral components to obtain the special high-fat milk powder for the kittens.
Example 2
The embodiment provides high-fat milk powder for kittens, which comprises the following components in parts by weight of 30 parts of fat component, 15 parts of protein component, 35 parts of carbohydrate, 3 parts of vitamin component and 5 parts of mineral component;
wherein the fat component is a combination of DHA algal oil powder, medium chain triglyceride (caprylic triglyceride), tributyrin, OPO structural lipid and lecithin, wherein the mass ratio of the DHA algal oil powder to the medium chain triglyceride (caprylic triglyceride) is 6.5;
the protein component is the combination of whey protein, casein, skimmed goat milk powder and taurine with the mass ratio of 1;
the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide in a mass ratio of 1;
the vitamin component comprises 30000IU of vitamin A and 30000IU of vitamin B per kilogram of vitamin component 2 10mg of vitamin B 6 30mg of vitamin B 12 0.5mg, 5000IU vitamin D and K vitamin 3 80mg, vitamin E10mg and folic acid 1mg.
The mineral composition comprises 150mg of zinc, 100mg of iron, 350mg of calcium, 15mg of manganese and 50mg of copper per kilogram.
The preparation method of the high-fat milk powder for the kitten comprises the following steps:
(1) Mixing medium chain triglyceride, tributyrin, OPO structural lipid and lecithin, heating to 45 deg.C, adding carbohydrate, lactalbumin, casein and defatted goat milk powder, stirring, adding 60 parts of water, heating the mixture to 70 deg.C, and homogenizing for 3min;
(2) Spray drying to obtain powder mixture with particle diameter of 0.05 mm;
(3) And uniformly mixing the powdery mixture with DHA algal oil powder, taurine, vitamin components and mineral components to obtain the special high-fat milk powder for the kittens.
Example 3
The embodiment provides high-fat milk powder for kittens, which comprises 20 parts by weight of fat component, 30 parts by weight of protein component, 45 parts by weight of carbohydrate, 1 part by weight of vitamin component and 2 parts by weight of mineral component;
wherein the fat component is a combination of DHA algal oil powder, medium chain triglyceride (capric triglyceride), tributyrin, OPO structural lipid and lecithin, the mass ratio of which is 4.5;
the protein component is a combination of whey protein, casein, skimmed sheep milk powder and taurine with the mass ratio of 0.5;
the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide with the mass ratio of 3;
the vitamin component comprises 20000IU of vitamin A and vitamin B in terms of per kilogram 2 15mg of vitamin B 6 20mg of vitamin B 12 1.5mg, vitamin D10000 IU, vitamin K 3 60mg, vitamin E15mg and folic acid 5mg.
The mineral composition contains 100mg of zinc, 200mg of iron, 200mg of calcium, 20mg of manganese and 30mg of copper per kilogram.
The preparation method of the high-fat milk powder for the kitten comprises the following steps:
(1) Mixing medium chain triglyceride, tributyrin, OPO structural lipid and lecithin, heating to 45 deg.C, adding carbohydrate, lactalbumin, casein and defatted sheep milk powder, stirring, adding 60 parts of water, heating the mixture to 75 deg.C, and homogenizing for 5min;
(2) Spray drying to obtain powder mixture with particle diameter of 0.1 mm;
(3) And uniformly mixing the powdery mixture with DHA algal oil powder, taurine, vitamin components and mineral components to obtain the special high-fat milk powder for the kittens.
Example 4
The present example provides a high-fat milk powder for kittens, which is different from example 1 in terms of the formulation composition of the fat component, wherein the fat component is a combination of DHA algal oil powder, medium chain triglyceride, tributyrin, OPO structural lipid, and lecithin in a mass ratio of 8.7.
Example 5
This example provides a high-fat milk powder for kittens, which has a formulation composition different from that of example 1 only in that the fat component is a combination of DHA algal oil powder, medium chain triglyceride, tributyrin, OPO structural lipid, and lecithin in a mass ratio of 3.7.
Example 6
The present example provides a high-fat milk powder for kittens, which is different from example 1 in terms of the formulation composition of the milk powder for kittens only in that the protein component is a combination of casein, skimmed goat milk powder and taurine in a mass ratio of 4.3.
Example 7
The present example provides a high-fat milk powder for kittens, which is different from example 1 in terms of the formulation composition of the milk powder for kittens only in that the protein component is a combination of whey protein, skimmed goat milk powder, and taurine in a mass ratio of 0.8.
Example 8
The present example provides a high-fat milk powder for kittens, which is different from example 1 only in that the protein component is a combination of whey protein, casein and taurine in a mass ratio of 0.8.4.3.
Example 9
The present example provides a high-fat milk powder for kittens, which has a formula composition different from that of example 1 only in that the protein component is a combination of whey protein, casein and skimmed sheep milk powder in a mass ratio of 0.8 to 4.3, and the addition amount of the protein component is kept unchanged, and the rest of the components are kept unchanged, and the preparation method is as in example 1.
Example 10
The present example provides a high-fat milk powder for kittens, which has a formula composition different from that of example 1 only in that the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide in a mass ratio of 5.
Example 11
This example provides a high-fat milk powder for kittens, which has a formulation composition different from that of example 1 only in that the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide in a mass ratio of 0.5.
Comparative example 1
This example provides a high-fat milk powder for kittens, which is formulated in a composition different from that of example 1 only in that the milk powder does not include vitamin components and the remaining components remain unchanged, according to example 1.
Comparative example 2
This example provides a high-fat milk powder for kittens, which has a formula composition different from that of example 1 only in that the milk powder does not include mineral components and the remaining components remain unchanged, according to example 1.
Comparative example 3
The present example provides a high-fat milk powder for kittens, which is different from example 1 only in that the fat component is a combination of medium-chain triglyceride, tributyrin, OPO structural lipid, and lecithin in a mass ratio of 2.3.
Comparative example 4
This example provides a high-fat milk powder for kittens, which has a formulation composition different from that of example 1 only in that the fat component is a combination of DHA algal oil powder, tributyrin, OPO structural fat, and lecithin in a mass ratio of 5.3.
Comparative example 5
This example provides a high-fat milk powder for kittens, which has a formulation composition different from that of example 1 only in that the fat component is a combination of DHA algal oil powder, medium-chain triglyceride, OPO structural fat and lecithin in a mass ratio of 5.2.5.
Comparative example 6
This example provides a high-fat milk powder for kittens, which has a formulation composition different from that of example 1 only in that the fat component is a combination of DHA algal oil powder, medium-chain triglyceride, tributyrin, and lecithin in a mass ratio of 5.3.
Comparative example 7
The present example provides a high-fat milk powder for kittens, which is different from example 1 in terms of the formulation composition of the milk powder for kittens only in that the fat component is a combination of DHA algal oil powder, medium-chain triglyceride, tributyrin, and OPO structural lipid in a mass ratio of 5.
Test example 1
200 healthy and disease-free Russian blue cat kittens with similar weights and ages were selected, randomly divided into 20 groups of 10 cats, and fed with the milk powders of examples 1-11 and comparative examples 1-7, respectively. Daily at 8, 11, 00, 15 and 18. Control 1 was fed breast milk only and control 2 was fed commercially available kitten milk powder.
Wherein the diarrhea rate (%) = total number of diarrhea in the group of kitten x 100/(total number of kitten in the group x number of test days);
fat digestibility (%) = (fat intake-fat content in feces) × 100/fat intake.
The test results are shown in Table 1.
TABLE 1
As can be seen from the data in table 1, the nutritional ingredients of the high-fat milk powder for the kittens in the embodiments 1 to 3 of the invention are closer to breast milk, and are easy to be digested and absorbed by the kittens, so that the kittens can be better promoted to grow rapidly, and the survival rate of the kittens is higher, wherein the daily gain of the kittens is more than 9.5 g/day, the fat digestion rate is more than 90%, and the effect is equivalent to that of breast feeding; compared with breast feeding, the diarrhea rate of the kittens is below 0.5 percent after the kittens use the high-fat milk powder, which shows that the milk powder provided by the invention can effectively reduce the diarrhea rate of the kittens.
From examples 4 and 5, it can be seen that when the mass ratio of the DHA algal oil meal, the medium chain triglyceride, the tributyrin, the OPO structural lipid, and the lecithin in the fat component is not within the range defined by the present invention, the daily gain of kittens is 8.29 or 7.19 g/day/cat, the fat digestibility is 88.01% or 86.38%, and the diarrhea rate is 4.76% or 3.81%, all indexes are reduced, which indicates that the mass ratio of each component in the fat component has an influence on the beneficial effects of the milk powder;
from examples 6 to 9, it can be seen that the lack of whey protein, casein, skimmed sheep milk powder and taurine in the protein components can reduce the daily gain of kittens and increase the diarrhea rate when any one of the components is absent;
from examples 10-11, it can be seen that the mass ratio of lactose, galacto-oligosaccharide and fructo-oligosaccharide in the carbohydrate also affects the effect of the milk powder in improving the daily weight gain, increasing the fat digestibility and reducing the diarrhea rate of kittens; as can be seen from the comparison between the example 1 and the comparative examples 1-2, when the vitamin component and the mineral component are added into the high-fat milk powder for the kitten, the nutrition of the milk powder can be more comprehensive, and the growth of the kitten can be better promoted;
from comparative examples 3 to 7, it is understood that DHA algal oil powder, medium chain triglyceride, tributyrin, OPO structural lipid and lecithin in the fat component have a synergistic effect in increasing daily gain, fat digestibility and reducing diarrhea rate of kittens, and the effect of the milk powder is deteriorated in the absence of any one of the components.
Therefore, the high-fat milk powder for the kittens provided by the invention can fully meet the nutrition required by the growth of the kittens, is easily digested and absorbed by the kittens, effectively reduces the diarrhea rate of the kittens, can improve the immunity of the kittens, and promotes the rapid growth of the kittens.
The applicant states that the present invention is illustrated by the above examples to the high fat milk powder for kittens and the preparation method and application thereof, but the present invention is not limited to the above detailed method, that is, it does not mean that the present invention must be implemented by the above detailed method. It should be understood by those skilled in the art that any modifications of the present invention, equivalent substitutions of the raw materials of the product of the present invention, and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. The high-fat milk powder for the kittens is characterized by comprising the following components in parts by weight: 20-30 parts of fat component, 15-30 parts of protein component, 35-45 parts of carbohydrate, 1-3 parts of vitamin component and 2-5 parts of mineral component;
the fat component is a combination of DHA algal oil powder, medium chain triglyceride, tributyrin, OPO structural lipid and lecithin.
2. The high-fat milk powder for kittens as claimed in claim 1, wherein the mass ratio of the DHA algal oil powder, the medium chain triglyceride, the tributyrin, the OPO structural lipid and the lecithin is (4-6): (1.5-2.5): (0.1-0.5): (1.5-3): (0.3-0.5).
3. The high-fat milk powder for kittens according to claim 1 or 2, wherein the protein component comprises any one of whey protein, casein, skim milk powder, skim sheep milk powder or taurine or a combination of at least two thereof;
preferably, the protein component is a combination of whey protein, casein, skim goat milk powder and taurine;
preferably, the mass ratio of the whey protein, the casein, the skimmed sheep milk powder and the taurine is (0.5-1): (4-4.5): (5-6.5): (0.1-0.5).
4. The high-fat milk powder for kittens according to any one of claims 1 to 3, wherein the carbohydrate comprises any one of maltose, glucose, lactose, galacto-oligosaccharide or fructo-oligosaccharide or a combination of at least two thereof;
preferably, the carbohydrate is a combination of lactose, galacto-oligosaccharide and fructo-oligosaccharide;
preferably, the mass ratio of the lactose, the galacto-oligosaccharide and the fructo-oligosaccharide is (1-3): (3-4): (0.5-1.5).
5. The high-fat milk powder for kittens according to any one of claims 1 to 4, wherein the vitamin component comprises vitamin A and vitamin B 2 Vitamin B 6 Vitamin B 12 Vitamin C, vitamin CBiotin (II) salt of biotin (III) 3 Vitamin K 3 Any one or combination of at least two of vitamin E and folic acid;
preferably, the vitamin component comprises 20000-30000IU of vitamin A and vitamin B per kilogram of the vitamin component 2 10-15mg, vitamin B 6 20-30mg, vitamin B 12 0.5-1.5mg, vitamin D5000-10000 IU, and vitamin K 3 60-80mg, 10-15mg of vitamin E and 1-5mg of folic acid.
6. The high-fat milk powder for kittens according to any one of claims 1 to 5, wherein the mineral composition comprises any one or at least two of zinc methionine, ferrous gluconate, calcium lactate, manganese methionine, and copper yeast;
preferably, each kilogram of the mineral component comprises 100-150mg of zinc, 100-200mg of iron, 200-350mg of calcium, 15-20mg of manganese and 30-50mg of copper.
7. The preparation method of high-fat milk powder for kittens as claimed in any one of claims 1 to 6, wherein the preparation method comprises the steps of:
(1) Mixing and heating part of fat components, then adding carbohydrate and part of protein components, continuously mixing and stirring, adding water after uniform mixing, heating, emulsifying and homogenizing to obtain a mixed solution;
(2) Spray drying the mixed solution to obtain a powdery mixture;
(3) And uniformly mixing the powdery mixture with the rest fat component, the rest protein component, the vitamin component and the mineral component to obtain the high-fat milk powder for the kittens.
8. The method according to claim 7, wherein the partial fat component in the step (1) is a combination of medium chain triglyceride, tributyrin, OPO structural lipid and lecithin;
preferably, the mixing of step (1) is heated to 40-45 ℃;
preferably, part of the protein components in the step (1) are the combination of whey protein, casein and defatted goat milk powder;
preferably, the mass ratio of the fat component to the water in the step (1) is 1 (2-3);
preferably, the temperature is raised to 70-75 ℃ in the step (1);
preferably, the emulsifying and homogenizing time in the step (1) is 3-5min.
9. The method according to claim 7 or 8, wherein the particle size of the powdery mixture of step (2) is 0.05-0.1mm.
10. A cat feed comprising the high-fat milk powder for kittens as claimed in any one of claims 1 to 6.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2025083077A1 (en) * | 2023-10-16 | 2025-04-24 | Nutreco Ip Assets B.V. | Fat composition comprising tributyrin and its use in calf milk replacers |
WO2025083081A1 (en) * | 2023-10-16 | 2025-04-24 | Nutreco Ip Assets B.V. | Fat composition comprising tributyrin and tricaproin and its use in milk replacers |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006094710A (en) * | 2004-09-28 | 2006-04-13 | Natl Fedelation Of Agricult Coop Assoc | Method for producing milk composition for larva |
CN107549458A (en) * | 2017-08-10 | 2018-01-09 | 上海信元宠物食品有限公司 | A kind of liquid is for dog cat breast milk dairy products and preparation method thereof |
CN110810632A (en) * | 2019-12-31 | 2020-02-21 | 江苏雅博动物健康科技有限责任公司 | Milk powder for replacing breast milk of newborn puppies and preparation method thereof |
CN112535243A (en) * | 2020-12-11 | 2021-03-23 | 南京欣腾瑞生物科技有限公司 | Young cat formula milk powder simulating cat breast milk and preparation method thereof |
CN114009617A (en) * | 2021-11-03 | 2022-02-08 | 上海福贝宠物用品股份有限公司 | Feed additive for improving intestinal health of weaned kittens and preparation method thereof |
-
2022
- 2022-09-20 CN CN202211145777.8A patent/CN115444073B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006094710A (en) * | 2004-09-28 | 2006-04-13 | Natl Fedelation Of Agricult Coop Assoc | Method for producing milk composition for larva |
CN107549458A (en) * | 2017-08-10 | 2018-01-09 | 上海信元宠物食品有限公司 | A kind of liquid is for dog cat breast milk dairy products and preparation method thereof |
CN110810632A (en) * | 2019-12-31 | 2020-02-21 | 江苏雅博动物健康科技有限责任公司 | Milk powder for replacing breast milk of newborn puppies and preparation method thereof |
CN112535243A (en) * | 2020-12-11 | 2021-03-23 | 南京欣腾瑞生物科技有限公司 | Young cat formula milk powder simulating cat breast milk and preparation method thereof |
CN114009617A (en) * | 2021-11-03 | 2022-02-08 | 上海福贝宠物用品股份有限公司 | Feed additive for improving intestinal health of weaned kittens and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2025083077A1 (en) * | 2023-10-16 | 2025-04-24 | Nutreco Ip Assets B.V. | Fat composition comprising tributyrin and its use in calf milk replacers |
WO2025083081A1 (en) * | 2023-10-16 | 2025-04-24 | Nutreco Ip Assets B.V. | Fat composition comprising tributyrin and tricaproin and its use in milk replacers |
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