CN115069316B - Chip capable of detecting multiple body fluids simultaneously - Google Patents

Abstract

The invention discloses a chip capable of detecting various body fluids simultaneously, which comprises a chip assembly, a plurality of groups of liquid inlet assemblies and a first reaction assembly, wherein the chip assembly is provided with a plurality of liquid inlet channels, and the chip assembly is provided with a plurality of mounting grooves; the liquid inlet component is arranged in the corresponding mounting groove; the first reaction component comprises a centralized injection seat, wherein a plurality of centralized injection ports communicated with the liquid inlet channels are arranged at one end of the centralized injection seat, the other end of the centralized injection seat is connected with a dispersed injection seat, a plurality of mutually independent liquid outlet grooves are formed at one end of the dispersed injection seat, a plurality of liquid outlet holes which correspond to the liquid outlet grooves one by one are arranged at the other end of the dispersed injection seat, a rotating ring is rotatably connected in a chip component at the other end of the first installation channel, a guide shaft is fixed in the chip component, and a reaction ring which is controlled by magnetic force and can be inserted on the rotating ring is slidably connected on the guide shaft; the invention can realize the simultaneous detection of various body fluids.

Description

A chip that can detect multiple bodily fluids simultaneously

technical field

The invention relates to the technical field of in vitro detection of cancer, in particular to a chip capable of simultaneously detecting multiple body fluids.

Background technique

Microfluidic technology is used to detect body fluids such as saliva, urine, and tears, and the sampling volume is small, which is suitable for on-site detection.

In the prior art, a Chinese utility model patent titled "a microfluidic saliva detection chip" with a publication number of CN 215996712U and a publication date of 2022.03.11 is disclosed, which includes an upper substrate and a lower substrate, the lower substrate It is fixedly arranged at the bottom of the upper base, and the left side of the upper base is detachably provided with a sliding filter mechanism, and the carrier plate in the sliding filter mechanism is slidably arranged inside the receiving tank in the sliding filter mechanism, which can be conveniently realized The detection of saliva, but the simultaneous detection of multiple body fluids cannot be realized, and the function is single.

Contents of the invention

The purpose of this section is to outline some aspects of embodiments of the invention and briefly describe some preferred embodiments. Some simplifications or omissions may be made in this section, as well as in the abstract and titles of this application, to avoid obscuring the purpose of this section, abstract and titles, and such simplifications or omissions should not be used to limit the scope of the invention.

In view of the above and/or problems existing in existing body fluid detection, the present invention is proposed.

Therefore, the object of the present invention is to provide a chip capable of simultaneously detecting multiple body fluids, which can realize the simultaneous detection of multiple body fluids.

In order to solve the above technical problems, the present invention provides the following technical solutions: a chip capable of simultaneously detecting multiple body fluids, which includes,

A chip assembly, one end of the chip assembly is provided with a first detection groove, and a first installation channel is arranged in the chip assembly, and a plurality of liquid inlet channels are arranged on the chip assembly at one end of the first installation channel, and a plurality of liquid inlet channels are arranged on the chip assembly. There are several installation slots;

A liquid inlet assembly, the liquid inlet assembly is provided with several groups and corresponds to the installation groove one by one, and the liquid inlet assembly is installed in the corresponding installation groove;

The first reaction assembly, the first reaction assembly includes a centralized injection seat fixed in the chip assembly and installed at one end of the first installation channel, one end of the centralized injection seat is arranged with a number of centralized injection ports communicated with the liquid inlet channel The other end of the concentrated injection seat is connected to a dispersed injection seat, and the one end of the dispersed injection seat opposite to the centralized injection seat is provided with a first liquid outlet, a second liquid outlet, a third liquid outlet and a fourth outlet The liquid tank, the end of the dispersed injection seat away from the concentrated injection seat is arranged with a number of first liquid outlets connected with the first liquid outlet, a second liquid outlet connected with the second liquid outlet, and a third outlet. A third liquid outlet connected to the liquid tank and a fourth liquid outlet connected to the fourth liquid outlet tank, a rotating ring is rotatably connected to the chip assembly at the other end of the first installation channel, and the dispersed injection seat is far away from the centralized One end of the injection seat is fixedly connected with a guide shaft, and the end of the guide shaft far away from the dispersed injection seat is fixedly connected in the chip assembly. The guide shaft is slidably connected with a reaction ring controlled by magnetic force, and the reaction ring is arranged with A number of magnetically controlled injection tubes corresponding to the first liquid outlet, corresponding to the second liquid outlet, corresponding to the third liquid outlet, and corresponding to the fourth liquid outlet, the side of the injection tube is opened There are a first inflow injection port and a second inflow injection port arranged at intervals in the axial direction, a first electromagnet is connected to the chip component at the first detection slot, and a number of corresponding injection tubes are arranged in the reaction ring. In the reaction solution storage pool, the magnetism of the reaction ring is smaller than that of the injection tube, and the reaction ring can be inserted into the rotating ring.

The reaction ring, the section of the chip assembly between the reaction ring and the detection tank is transparent; in the initial state, the reaction ring is closely attached to the side of the dispersed injection seat away from the centralized injection seat, and there are four liquid inlet channels. Each liquid inlet component feeds different body fluids into the corresponding liquid inlet channels, and the different body fluids enter the respective centralized injection ports through the corresponding liquid inlet channels, and the body fluids flowing out of the four centralized injection ports enter the first liquid outlet tank, the second liquid outlet respectively. In the second liquid outlet tank, the third liquid outlet tank and the fourth liquid outlet tank, the body fluid in the first liquid outlet tank is divided into several roads and output from several first liquid outlets, and enters the injection through the corresponding first inflow and injection ports respectively. In the pipe, the body fluid in the second liquid outlet tank enters the corresponding injection pipe through the second liquid outlet and the corresponding first inflow and injection port sequentially, and the body fluid in the third liquid outlet tank sequentially passes through the third liquid outlet and the corresponding first liquid outlet. The first inflow and injection port enters the corresponding injection pipe, and the body fluid in the fourth liquid outlet tank enters the corresponding injection pipe through the fourth liquid outlet and the corresponding first inflow and injection port in sequence. The strength of the first electromagnet makes the injection pipe suck into the corresponding reaction liquid storage pool, the reaction ring does not move, the outer end of the injection pipe just seals the reaction ring, and the body fluid reacts with the reaction liquid in the reaction liquid storage pool. One electromagnet strength, the reaction ring slides along the guide shaft toward the direction of the rotating ring until the reaction ring slides onto the rotating ring, and the rotating ring rotates to fully mix the body fluid and the reaction liquid, then the rotating ring stops rotating. A color sensor is set in the detection tank, and the rotating ring rotates so that the reaction liquid storage pool is aligned with the color sensor, and the color change after the reaction is identified for analysis; the present invention realizes the detection of various body fluids through the joint arrangement of the first reaction component and the chip component. Simultaneous detection to improve detection efficiency.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids described in the present invention, wherein: the reaction ring on the side where the reaction liquid storage tank is set opposite to the injection tube has a closed port, and the closed port and the reaction ring are far away from the reaction liquid A liquid injection chamber is formed between the inner walls of one end of the storage pool, and the end of the injection pipe far away from the dispersed injection seat is provided with a sealing part, and the sealing part can just block the sealing port, and the first inflow and injection port of the injection pipe is at the corresponding first When the first liquid outlet is inside, the second inflow and injection port is inside the liquid injection cavity.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, wherein: the liquid inlet assembly includes a liquid inlet housing that is liftably connected in a corresponding installation sink and has an upward opening, and the inlet A pressure plate is slidably connected to the inside of the liquid housing, and the center of the liquid inlet housing is fixedly connected to a central axis, and one end of the central axis protruding upward from the liquid inlet housing is fixedly connected to a fixed ring, and at least two straight lines are arranged on the fixed ring The driver, the linear driver is connected with a telescopic rod capable of reciprocating linear movement in the height direction, the lower end of the telescopic rod is connected to the upper side of the pressure plate, and an upward sinking hole is opened on the central axis, so A liquid inlet is opened on the side of the central shaft below the pressure plate, and a liquid inlet cavity is formed between the lower side of the pressure plate and the inner wall of the liquid inlet housing.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, it further includes a second reaction assembly, a second installation channel is also provided in the chip assembly, and the second reaction assembly includes a The first storage shell and several second storage shells in the second installation channel, the chip assembly is provided with a vertically arranged reaction liquid flow channel, and the inner cavity of the first storage shell can be connected with the reaction liquid flow channel The inner cavity of the second storage shell can be communicated with the reaction liquid flow channel, the inner cavity of the first storage shell can be communicated with the liquid inlet cavity in one of the liquid inlet components, and several A group of reaction units connected end to end, the reaction unit includes a first reaction channel, one end of the first reaction channel in the reaction unit at the head end communicates with the reaction liquid flow channel, and the other end of the first reaction channel is connected to one end of the second reaction channel , the other end of the second reaction channel communicates with one end of the third reaction channel, and in two adjacent reaction units, the other end of the previous third reaction channel communicates with one end of the next first reaction channel.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids described in the present invention, wherein: the chip assembly is fixedly connected with a reaction liquid control motor, and the reaction liquid control motor is connected with a downward protruding liquid injection The side of the first storage case opposite to the liquid injection tube is provided with a first liquid inlet, the side of the second storage case opposite to the liquid injection pipe is provided with a second liquid inlet, and the liquid injection One end of the tube can be attached to the outside of the first liquid inlet part and aligned with the first liquid inlet part or attached to the outside of the second liquid inlet part and aligned with the second liquid inlet part, and the other end of the liquid injection tube is fixedly connected to There is a first liquid suction pump, and the lower end of the liquid injection pipe is connected to the upper end of the reaction liquid flow channel.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, wherein: the first reaction channel and the second reaction channel are arranged in parallel, and the chip assembly between the first reaction channel and the second reaction channel A plurality of reaction pools are arranged, and the chip assembly on the side facing the reaction pools of the first reaction channel and the third reaction channel is provided with a reaction liquid drainage hole.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, wherein: the chip assembly at the other end of the third reaction channel in the terminal reaction unit is provided with a waste liquid outlet channel, and the chip assembly is provided with There is a waste liquid pool, and the end of the waste liquid outlet channel away from the end of the third reaction channel is connected to the waste liquid pool.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, wherein: the chip assembly at the end of the waste liquid pool away from the reaction unit is connected with a second pump.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, wherein: the chip assembly includes a first chip body and a second chip body sequentially connected together from bottom to top, and the first chip There is a mounting sinker on the upward side of the body, and a mounting opening corresponding to the mounting sinking is opened on the second chip body, the mounting sinking and the mounting port form the first installation channel, and the third chip The body seals the first installation channel, and several groups of lower reaction units connected end to end are arranged on the upward side of the first chip body, and the lower reaction units include the first lower reaction liquid flow connected in sequence channel, the second lower reaction liquid flow channel and the third lower reaction liquid flow channel, and the end of the second chip body facing downward is arranged with several groups of upper reaction units connected end to end, and the upper reaction units include sequentially connected to the first The upper reaction liquid flow channel, the second upper reaction liquid flow channel and the third lower reaction liquid flow channel, the first lower reaction liquid flow channel and the corresponding first upper reaction liquid flow channel form a first A reaction channel, a second reaction channel with closed upper and lower ends is formed between the second lower reaction liquid flow channel and the corresponding second upper reaction liquid flow channel, and the third lower reaction liquid flow channel and the corresponding third upper reaction liquid flow channel A third reaction channel with closed upper and lower ends is formed between the liquid flow channels.

As a preferred solution of the chip capable of simultaneously detecting multiple body fluids in the present invention, wherein: a transmission motor is fixedly connected in the first installation channel of the chip assembly, and the transmission motor is connected with a rotating ring through a transmission belt.

Beneficial effects of the present invention: the present invention realizes the simultaneous detection of various body fluids through the joint arrangement of the first reaction component and the chip component, and improves the detection efficiency; through the setting of the second reaction component and the liquid inlet component, the detection of different proteins in saliva is realized detection.

Description of drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For Those of ordinary skill in the art can also obtain other drawings based on these drawings without any creative effort. in:

Fig. 1 is the front view of the present invention.

Fig. 2 is an exploded structure diagram 1 of the present invention.

FIG. 3 is a partial enlarged view of A in FIG. 2 .

FIG. 4 is a three-dimensional structure diagram 1 after hiding the fifth chip body, the fourth chip body and the second reaction component in the present invention.

Fig. 5 is a three-dimensional structural view of the centralized injection seat in the present invention.

Fig. 6 is a three-dimensional structural view of the dispersion injection seat in the present invention.

Fig. 7 is a three-dimensional structure diagram of the liquid inlet assembly in the present invention.

FIG. 8 is a partial enlarged view of B in FIG. 7 .

FIG. 9 is a three-dimensional structure diagram 1 after the fifth chip body is hidden in the present invention.

FIG. 10 is a partially enlarged view at point C in FIG. 9 .

Fig. 11 is a three-dimensional structure diagram of the reaction ring closely attached to the dispersion injection seat in the present invention.

Fig. 12 is a structural diagram of the reaction loop in the present invention.

Fig. 13 is a view from the direction of H-H in Fig. 12 .

Fig. 14 is the second exploded structure diagram of the present invention.

FIG. 15 is a partial enlarged view at D in FIG. 14 .

FIG. 16 is a partial enlarged view at E in FIG. 14 .

FIG. 17 is the second three-dimensional structure diagram after the fifth chip body is hidden in the present invention.

FIG. 18 is a partially enlarged view at point F in FIG. 17 .

FIG. 19 is a three-dimensional structural view of the first reaction component connected to the first chip body in the present invention.

FIG. 20 is a partial enlarged view at G in FIG. 19 .

FIG. 21 is a three-dimensional structure diagram of the fifth chip body in the present invention.

In the figure, 100 chip assembly, 101 fifth chip body, 101a reaction liquid inlet hole, 101b liquid outlet, 101c first upper liquid outlet channel, 102 fourth chip body, 102a first vertical through hole, 102b first 102c lower waste liquid flow channel, 103 third chip body, 103a second vertical through hole, 103b first detection sink, 104 second chip body, 104a third vertical through hole, 104b Upper reaction unit, 104b-1 second upper reaction liquid flow channel, 104b-2 first upper reaction liquid flow channel, 104b-3 third upper reaction liquid flow channel, 104c installation port, 104d upper waste liquid flow channel, 105th A chip body, 105a reaction solution inlet sink, 105b lower reaction unit, 105b-1 third lower reaction solution channel, 105b-2 second lower reaction solution channel, 105b-3 first lower reaction solution channel, 105b-4 reaction liquid drain hole, 105b-5 reaction pool, 105b-6 detection chamber, 105c lifting hole, 105d fourth liquid inlet channel, 105e second liquid inlet channel, 105f first liquid inlet channel, 105g third inlet Liquid channel, 105h installation sink, 106 first detection groove, 107 installation groove, 107a fourth connection port, 107b third connection port, 107c second connection port, 107d first connection port, 107e connection sinker, 200 injection needle , 300 liquid inlet assembly, 301 fourth liquid inlet assembly, 301a liquid inlet shell, 301a-1 liquid outlet hole, 301a-2 liquid discharge part, 301b fixed ring, 301c central shaft, 301c-1 liquid inlet, 301d linear drive , 301e guide rod, 301f guide sleeve, 301g fixed outer ring, 302 third liquid inlet assembly, 303 second liquid inlet assembly, 304 first liquid inlet assembly, 400 first reaction assembly, 401 centralized injection seat, 401a centralized injection port , 401b first liquid outlet tank, 401c second liquid outlet tank, 401d third liquid outlet tank, 401e fourth liquid outlet tank, 402 dispersed injection seat, 402a first liquid inlet tank, 402b first liquid outlet port, 402c first liquid outlet Second liquid outlet, 402d second liquid inlet tank, 402e third liquid outlet, 402f third liquid inlet tank, 402g third liquid outlet, 402h fourth liquid inlet tank, 403 reaction ring, 403a liquid injection chamber, 403b Closed port, 403c reaction liquid storage tank, 404 guide shaft, 405 transmission motor, 406 rotating ring, 407 transmission belt, 408 first installation channel, 409 first electromagnet, 410 injection pipe, 410a first inflow injection port, 410b second Inflow injection port, 410c sealing part, 411 sealing plug, 500 second reaction component, 501 reaction liquid control motor, 502 first liquid suction pump, 503 liquid injection pipe, 504 second storage shell, 504a second liquid inlet part, 505 The second metal sheet, 505a the second limiting part, 506 the first storage shell, 506a the first liquid inlet part, 507 the first metal sheet, 507a the first limiting part, 508 the second electromagnet, 509 the mounting seat, 510 the first Two suction pumps, 600 second detection tank.

Detailed ways

Before setting forth the technical scheme of the present invention, define the terms used herein as follows:

In order to make the above objects, features and advantages of the present invention more obvious and comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings.

In the following description, a lot of specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways different from those described here, and those skilled in the art can do it without departing from the meaning of the present invention. By analogy, the present invention is therefore not limited to the specific examples disclosed below.

Second, "one embodiment" or "an embodiment" referred to herein refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present invention. "In one embodiment" appearing in different places in this specification does not all refer to the same embodiment, nor is it a separate or selective embodiment that is mutually exclusive with other embodiments.

Example 1

Referring to Fig. 1 to Fig. 13, it is the first embodiment of the present invention. This embodiment provides a chip capable of detecting multiple body fluids at the same time, which can realize simultaneous detection of multiple body fluids and has high detection efficiency.

A chip capable of simultaneously detecting multiple body fluids, comprising a chip assembly 100, a first detection groove 106 is opened at one end of the chip assembly 100, a first installation channel 408 is provided in the chip assembly 100, and a chip at one end of the first installation channel 408 A number of liquid inlet channels are arranged on the module 100, and a number of installation grooves 107 are arranged on the chip module 100. The chip module 100 is connected with a liquid inlet module 300 through the installation grooves 107, and the chip module 100 is connected with various fluid acid and alkali detectors. The first reaction assembly 400 is a characteristic first reaction assembly 400, the first reaction assembly 400 includes a centralized injection seat 401 fixed in the chip assembly 100 and installed at one end of the first installation channel 408, and one end of the centralized injection seat 401 is arranged to communicate with the liquid inlet channel. The other end of the concentrated injection seat 401 is connected with a dispersed injection seat 402, and one end of the dispersed injection seat 402 opposite to the centralized injection seat 401 has a first liquid outlet 401b, a second liquid outlet 401c, The third liquid outlet groove 401d and the fourth liquid outlet groove 401e, one end of the dispersed injection seat 402 relative to the centralized injection seat 401 has a first liquid inlet groove 402a corresponding to the first liquid outlet groove 401b, and a second liquid outlet groove 401c The corresponding second liquid inlet groove 402d, the third liquid inlet groove 402f corresponding to the third liquid outlet groove 401d, and the fourth liquid inlet groove 402h corresponding to the fourth liquid outlet groove 401e, the dispersed injection seat 402 is far away from the concentrated injection seat 401 One end of one side is arranged with several first liquid outlets 402b communicating with the first liquid outlet 401b, one second liquid outlet 402c communicating with the second liquid outlet 401c, and one second liquid outlet 402c communicating with the third liquid outlet 401d. Three liquid outlets 402e and a fourth liquid outlet 402g communicating with the fourth liquid outlet tank 401e, the other end of the first installation channel 408 is rotatably connected to the chip assembly 100 with a rotating ring 406, specifically, the chip assembly 100 The transmission motor 405 is fixedly connected in the first installation channel 408 of the first installation channel 408, the transmission motor 405 is connected with the rotating ring 406 through the transmission belt 407, and the end of the dispersed injection seat 402 away from the concentrated injection seat 401 is fixedly connected with a guide shaft 404, and the guide shaft 404 is far away from the dispersed injection seat. One end of the seat 402 is fixedly connected in the chip assembly 100, the rotating ring 406 is rotatably connected to the guide shaft 404, and the guide shaft 404 is slidably connected with a reaction ring 403 controlled by magnetic force. The magnetically controlled injection tube 410 corresponding to the first liquid outlet 402b, corresponding to the second liquid outlet 402c, corresponding to the third liquid outlet 402e, and corresponding to the fourth liquid outlet 402g, the injection tube 410 The side part is provided with a first inflow injection port 410a and a second inflow injection port 410b arranged axially at intervals, a first electromagnet 409 is connected to the chip assembly 100 at the first detection slot 106, and a number of The reaction liquid storage tank 403c corresponding to the injection pipe 410 one-to-one, the side of the reaction ring 403 relative to the rotating ring 406 is arranged with a number of sealing ports corresponding to the reaction liquid storage tank 403c one-to-one, and a sealing plug 411 is connected to the sealing port. Inject the reaction liquid into the reaction liquid storage tank 403c through the sealing port, after the injection is completed, the sealing plug 411 is connected to the reaction ring 403 through the sealing port, so as to facilitate the liquid inlet of the reaction liquid, and the magnetism of the reaction ring 403 is smaller than that of the injection pipe 410 The reaction ring 403 can be inserted into the rotating ring 406, and the reaction ring 403 on the side where the reaction solution storage tank 403c is arranged opposite to the injection pipe 410 has a closed port 403b, and the closed port 403b and the reaction ring 403 are far away from the end of the reaction solution storage tank 403c. An injection cavity 403a is formed between the inner walls, and the end of the injection tube 410 away from the dispersed injection seat 402 is provided with a sealing portion 410c, which can just block the sealing port 403b, and the first inflow injection port 410a of the injection tube 410 is at the corresponding first When the first liquid outlet 402b is inside, the second inflow and injection port 410b is inside the liquid injection chamber 403a.

Further, the liquid inlet assembly 300 includes a liquid inlet housing 301a that is liftably connected in the corresponding installation sink 105h and has an upward opening. The chip assembly 100 on the lower side of the liquid inlet assembly 300 has a lift hole 105c. 301a is provided with a drain part 301a-2 on the outer side of the lower part, and a liquid outlet hole 301a-1 is opened on the liquid drain part 301a-2. The central axis 301c, one end of the central axis 301c protruding upward from the liquid inlet housing 301a is fixedly connected with a fixed ring 301b, the central axis 301c below the fixed ring 301b is fixedly connected with a fixed outer ring 301g, and the outer periphery of the fixed outer ring 301g is attached to the compression plate There is an extensible film between the fixed outer ring 301g and the pressure plate, which is a prior art, not shown, and a tpu waterproof membrane can be used. In the initial state, the fixed outer ring 301g is flush with the upper side of the pressure plate, and the film In the folded state, at least two linear actuators 301d are arranged on the fixed ring 301b, and several guide sleeves 301f are arranged on the fixed ring 301b between the linear actuators 301d, and guide rods 301e are slidably connected to the guide sleeves 301f. The lower side of the guide rod 301e is connected to the upper side of the pressing plate, and the linear driver 301d is connected with a telescopic rod 301h capable of reciprocating linear movement in the height direction. There is a liquid inlet sink hole on the top, and a liquid inlet 301c-1 is opened on the side of the central axis 301c below the pressure plate, and a liquid inlet chamber is formed between the lower side of the pressure plate and the inner wall of the liquid inlet housing 301a, and the liquid inlet chamber and the liquid outlet hole 301a-1 connected.

When entering the liquid, insert the injection needle 200 into the central shaft 301c, inject the body fluid into the central shaft 301c through the injection needle 200, enter the liquid inlet chamber through the liquid inlet 301c-1 on the central shaft 301c, move the pressing plate down, and the film unfolds, so that The pressure plate and the fixed outer ring 301g are always in a sealed state, and the downward movement of the pressure plate promotes the discharge of the body fluid in the liquid inlet chamber through the liquid outlet hole 301a-1; A peristaltic pump is connected to promote the discharge of body fluid through the outlet hole 301a-1.

In this embodiment, there are four liquid inlet channels, namely the first liquid inlet channel 105f, the second liquid inlet channel 105e, the third liquid inlet channel 105g and the fourth liquid inlet channel 105d, and the liquid inlet assembly 300 is provided with four group, the four liquid inlet assemblies 300 are respectively the first liquid inlet assembly 304, the second liquid inlet assembly 303, the third liquid inlet assembly 302 and the fourth liquid inlet assembly 301, and the first liquid inlet assembly 304 outputs urine to the first The liquid inlet channel 105f, the second liquid inlet assembly 303 outputs sweat to the second liquid inlet channel 105e, the third liquid inlet assembly 302 outputs tears to the third liquid inlet channel 105g, and the fourth liquid inlet assembly 301 outputs saliva to the fourth liquid inlet Channel 105d, urine sequentially passes through the first liquid inlet channel 105f, the corresponding concentrated injection port 401a, the first liquid outlet tank 401b, the first liquid inlet tank 402a, the first liquid outlet port 402b and the corresponding first inflow and injection port 410a into the injection tube 410.

The reaction ring 403, the section of the chip assembly 100 between the reaction ring 403 and the detection tank is all transparent; before the detection, it is the prior art to arrange some lifting structures that cooperate with the liquid inlet assembly 300 on the lower side of the chip. Draw its specific structure. The lifting structure can be a lifting driver. The lifting driver is connected with a lifting rod that protrudes upwards and can move reciprocatingly in a straight line. The lifting rod can just pass through the lifting hole 105c and contact the bottom side of the liquid inlet shell 301a. When the liquid housing 301a is in contact with the bottom of the chip assembly 100, the liquid outlet hole 301a-1 of the first liquid inlet assembly 304 communicates with the first liquid inlet channel 105f, and the liquid outlet hole 301a-1 of the second liquid inlet assembly 303 communicates with the second liquid inlet assembly 303. The liquid inlet channel 105e is connected, the liquid outlet hole 301a-1 of the third liquid inlet component 302 is connected with the third liquid inlet channel 105g, and the liquid outlet hole 301a-1 of the fourth liquid inlet component 301 is connected with the fourth liquid inlet channel 105d; In the initial state, the reaction ring 403 is closely attached to the side of the dispersed injection seat 402 away from the concentrated injection seat 401. There are four liquid inlet channels, and different body fluids are passed into the corresponding liquid inlet channels through each liquid inlet assembly 300 , different body fluids enter each concentrated injection port 401a through corresponding liquid inlet channels, and the body fluids flowing out of the four centralized injection ports 401a respectively enter the first liquid outlet tank 401b, the second liquid outlet tank 401c, and the third liquid outlet tank 401d and in the fourth liquid outlet tank 401e, the body fluid in the first liquid outlet tank 401b is divided into several paths, respectively output from several first liquid outlets 402b, and enters into the injection pipe 410 through the corresponding first inflow and injection ports 410a respectively. The body fluid in the second liquid outlet tank 401c enters the corresponding injection pipe 410 through the second liquid outlet 402c and the corresponding first inflow and injection port 410a sequentially, and the body fluid in the third liquid outlet tank 401d sequentially passes through the third liquid outlet 402e And the corresponding first inflow and injection port 410a enters the corresponding injection tube 410, and the body fluid in the fourth liquid outlet tank 401e enters the corresponding injection tube 410 through the fourth liquid outlet 402g and the corresponding first inflow and injection port 410a in sequence , the liquid feeding is completed, the first electromagnet 409 is energized, and the strength of the first electromagnet 409 is adjusted, so that the injection pipe 410 is sucked into the corresponding reaction liquid storage pool 403c, the reaction ring 403 does not move, and the outer end of the injection pipe 410 is just sealed. Hold the reaction ring 403, the body fluid reacts with the reaction liquid in the reaction liquid storage tank 403c, increase the strength of the first electromagnet 409, and make the reaction ring 403 slide along the guide shaft 404 toward the direction of the rotating ring 406 until the reaction ring 403 Sliding onto the rotating ring 406, the transmission motor 405 moves, and the rotating ring 406 is driven to rotate through the transmission belt 407. After the body fluid and the reaction liquid are fully mixed, the reaction liquid storage pool 403c is aligned with the color sensor in turn, and the color sensor recognizes the color change after the reaction in turn. , so as to analyze; the present invention realizes the simultaneous detection of multiple body fluids through the combined arrangement of the first reaction component 400 and the chip component 100, and improves the detection efficiency.

Example 2

Referring to Fig. 14 to Fig. 21, it is the second embodiment of the present invention. The difference from the second embodiment is that this embodiment provides a chip capable of simultaneously detecting multiple body fluids. This embodiment can realize Detection of various proteins in saliva.

A chip capable of simultaneously detecting multiple body fluids, further comprising a second reaction assembly 500, the second reaction assembly 500 is on the chip assembly 100 between the fourth liquid inlet assembly 301 and the third liquid inlet assembly 302, inside the chip assembly 100 A second installation channel is also provided. The second reaction assembly 500 includes a first storage shell 506 and several second storage shells 504 connected in the second installation channel. The chip assembly 100 is provided with a vertically arranged reaction liquid flow channel. , the inner cavity of the first storage shell 506 can communicate with the reaction liquid flow channel, the inner cavity of the second storage shell 504 can communicate with the reaction liquid flow channel, and the inner cavity of the first storage shell 506 can communicate with one of the liquid inlet components The liquid inlet chamber in 300 is connected, and there are several groups of reaction units connected end to end in the chip assembly 100. The reaction units include a first reaction channel, and one end of the first reaction channel in the reaction unit at the head end communicates with the reaction liquid flow channel. , the other end of the first reaction channel is connected to one end of the second reaction channel, and the other end of the second reaction channel is connected to one end of the third reaction channel. In two adjacent reaction units, the other end of the previous third reaction channel is connected to the next One end of a reaction channel is connected.

In order to further realize simultaneous detection of various proteins in saliva, a reaction liquid control motor 501 is fixedly connected to the chip assembly 100, and a liquid injection tube 503 protruding downward is connected to the reaction liquid control motor 501, and the first storage shell 506 is opposite to the injection pipe. One side of the liquid pipe 503 is provided with a first liquid inlet 506a, and the side of the second storage shell 504 opposite to the liquid injection pipe 503 is provided with a second liquid inlet 504a, and one end of the liquid injection pipe 503 can be attached to the second One liquid inlet part 506a outside and aligned with the first liquid inlet part 506a or attached to the outside of the second liquid inlet part 504a and aligned with the second liquid inlet part 504a, the other end of the liquid injection tube 503 is fixedly connected with the first liquid suction The pump 502, the lower end of the liquid injection pipe 503 is connected to the upper end of the reaction liquid flow channel, the first reaction channel and the second reaction channel are arranged in parallel, and the chip assembly 100 is arranged between the first reaction channel and the second reaction channel There are several reaction pools 105b-5, and the first reaction channel and the third reaction channel are provided with a reaction solution drain hole 105b-4 on the chip assembly 100 facing the side of the reaction pool 105b-5, and the third reaction channel in the terminal reaction unit The chip assembly 100 at the other end is provided with a waste liquid outlet channel, and the chip assembly 100 is provided with a waste liquid pool. A second pump 510 is connected to the chip assembly 100 at one end of the reaction unit.

Further, the chip assembly 100 includes the first chip body 105, the second chip body 104, the third chip body 103, the fourth chip body 102 and the fifth chip body 101 which are sequentially connected together from bottom to top, and the guide shaft 404 is away from One end of the dispersed injection seat 402 is fixedly connected in the first chip body 105; the upward side of the first chip body 105 is arranged with four connecting sinks 107e in a rectangular arrangement, and the second chip body 104 is arranged with four A first connection port 107d arranged in a rectangle, four second connection ports 107c arranged in a rectangle are arranged on the third chip body 103, four third connections arranged in a rectangle are arranged on the fourth chip body 102 port 107b, the fifth chip body 101 is arranged with four fourth connection ports 107a arranged in a rectangular shape, the fourth connection port 107a, the third connection port 107b, the second connection port 107c, the first connection port 107d and the corresponding Connect the sinker groove 107e to form the installation groove 107; the first detection groove 106 is arranged on the side ends of the first chip body 105, the second chip body 104 and the third chip body 103; the upward side of the first chip body 105 is provided with a bottom The waste liquid flow channel 102c, the side of the second chip body 104 facing downward is provided with an upper waste liquid flow channel 104d corresponding to the lower waste liquid flow channel 102c, and the lower waste liquid flow channel 102c and the upper waste liquid flow channel 104d form a waste liquid pool; the fourth chip body 102 has a first vertical through hole 102a aligned with the vertical section of the liquid injection pipe 503, and the third chip body 103 has a second vertical hole 102a coaxial with the first vertical through hole 102a. Vertical through hole 103a, the second chip body 104 has a third vertical through hole 104a coaxial with the second vertical through hole 103a, the first chip body 105 has a reaction liquid inlet on the upward side The sinking tank 105a, the first vertical through hole 102a, the second vertical through hole 103a, the third vertical through hole 104a and the reaction liquid inlet sinking tank 105a form a reaction outlet flow channel, and the first chip body 105 faces upward. One side is provided with an installation sinker 105h, and the second chip body 104 is provided with an installation port 104c corresponding to the installation sinker 105h. The installation sinker 105h and the installation port 104c form a first installation channel 408, and the third chip body 103 connects the first The installation channel 408 is closed, and the upward side of the first chip body 105 is arranged with several groups of lower reaction units 105b connected end to end, and the lower reaction units 105b include two groups of first lower reaction liquid flow channels 105b which are sequentially connected together -3. The second lower reaction liquid flow channel 105b-2 and the third lower reaction liquid flow channel 105b-1, and the downward end of the second chip body 104 is arranged with several groups of upper reaction units 104b connected end to end, the upper reaction The unit 104b includes two groups connected sequentially to the first upper reaction liquid flow channel 104b-2, the second upper reaction liquid flow channel 104b-1 and the third lower reaction liquid flow channel 105b-1, the first lower reaction liquid flow channel 105b- 3 and the corresponding first upper reaction liquid flow channel 104b-2 to form a first reaction channel with closed upper and lower ends, and between the second lower reaction liquid flow channel 105b-2 and the corresponding second upper reaction liquid flow channel 104b-1 A second reaction channel with closed upper and lower ends is formed between them, a third reaction channel with closed upper and lower ends is formed between the third lower reaction liquid flow channel 105b-1 and the corresponding third upper reaction liquid flow channel 104b-3, and the first reaction channel The upward side of the first chip body 105 and the downward side of the second chip body 104 between the third reaction channel form a detection chamber 105b-6, and the first reaction channel and the third reaction channel face the detection chamber 105b-6. The first chip body 105 on one side of 6 has a reaction solution drain hole 105b-4, and the reaction pools 105b-5 are all arranged on the first chip body 105 corresponding to the position of the detection chamber 105b-6. The reaction pool 105b-5 is coated with different antibodies, and the downward end of the fifth chip body 101 has a connection groove, the reaction liquid control motor 501 is fixedly connected in the fifth chip body 101 through the connection groove, and the liquid injection pipe 503 is rotatable Ground is connected in the fourth chip body 102, the side of the fifth chip body 101 close to the first storage shell 506 facing downward is provided with a first upper liquid outlet channel 101c, and the side of the fourth chip body 102 facing upward is provided with The first lower liquid outlet channel 102b corresponding to the first upper liquid outlet channel 101c, the first upper liquid outlet channel 101c and the first lower liquid outlet channel 102b form a first liquid outlet channel, and the first liquid outlet channel One end can be aligned with the liquid outlet hole 301a-1 of the liquid inlet housing 301a in the fourth liquid inlet assembly 301, the first liquid inlet channel 105f, the second liquid inlet channel 105e, the third liquid inlet channel 105g and the fourth liquid inlet channel 105d One end of the first chip body 105 is provided with a first lower liquid inlet channel, a second lower liquid inlet channel, a third lower liquid inlet channel, and a third lower liquid inlet channel. The lower liquid inlet channel and the fourth lower liquid inlet channel, the side of the second chip body 104 facing downward is provided with a first upper liquid inlet channel corresponding to the first lower liquid inlet channel and a second lower liquid inlet channel The second upper liquid inlet channel corresponding to the channel, the third upper liquid inlet channel corresponding to the third lower liquid inlet channel, and the fourth upper liquid inlet channel corresponding to the fourth lower liquid inlet channel, the first lower liquid inlet flow channel The first liquid inlet channel and the first upper liquid inlet channel form the first liquid inlet channel 105f, the second lower liquid inlet channel and the second upper liquid inlet channel form the second liquid inlet channel 105e, the third lower liquid inlet channel and the first three inlet channels The liquid channel forms the third liquid inlet channel 105g, the fourth lower liquid inlet channel and the fourth upper liquid inlet channel form the fourth liquid inlet channel 105d, and the other end of the first liquid outlet channel and the first storage shell 506 are away from the first One end of the liquid inlet part 506a is connected, and a mounting seat 509 is slidably connected in the fourth chip body 102. The mounting seat 509 is fixedly arranged on the side of the liquid injection tube 503 facing downward away from the end of the first liquid pump 502. The mounting seat 509 The second electromagnet 508 is fixedly connected, and the end of the first storage case 506 close to the first liquid inlet portion 506a is liftably connected with the first metal sheet 507, and the upper part of the first metal sheet 507 is provided with a first limiting portion 507a, In the initial state, the first limiting portion 507a is in contact with the upper side of the first storage case 506, the first metal sheet 507 separates the inner cavity of the first storage case 506 from the first liquid inlet portion 506a, and the second storage case 504 One end close to the second liquid inlet portion 504a is liftably connected to a second metal piece 505, and the upper part of the second metal piece 505 is provided with a second limiting portion 505a. In the initial state, the second limiting portion 505a is in contact with the second On the upper side of the storage case 504, the second metal sheet 505 separates the inner cavity of the second storage case 504 from the second liquid inlet portion 504a, and the second electromagnet 508 can be aligned with the first metal sheet 507 or the second metal sheet 505 .

In the initial state, the liquid injection pipe 503 raises the second liquid inlet assembly 303 through the external lifting driver, and when the liquid outlet hole 301a-1 moves up to align with the end of the first liquid outlet channel, the lifting driver stops acting and the injection The needle 200 feeds saliva into the liquid inlet cavity, and the saliva enters the first storage shell 506 through the liquid outlet hole 301a-1 and the first liquid outlet channel in turn; the side parts of the third chip body 103 and the side parts of the fourth chip body 102 are respectively A first detection sinker 103b and a second detection sinker are provided, the first detection sinker 103b and the second detection sinker form a second detection tank 600, and the second detection tank 600 covers the area where each reaction unit is located. In this embodiment There are four sets of reaction units, and each set of reaction units realizes the detection of different proteins in saliva; in order to facilitate the liquid inlet in the second storage shell 504, the upward side of the second storage shell 504 has a reaction liquid inlet hole 101a , the fifth chip body 101 is arranged with a number of injection holes corresponding to the reaction liquid inlet holes 101a one-to-one, and the lower side of the fifth chip body 101 is arranged with a number of injection holes corresponding to the liquid injection part 101b. The part 101b is inserted into the corresponding reaction liquid inlet hole 101a in the second storage shell 504 .

Taking the detection of transferrin in saliva as an example, the detection method includes the following steps:

(1) Control the action of the second electromagnet 508 to move the first metal piece 507 upwards, the first liquid inlet part 506a communicates with the liquid injection pipe 503, and the first liquid suction pump 502 operates to suck the saliva in the first storage case 506 , the saliva enters the first reaction channel, the second reaction channel and the third reaction channel successively through the reaction liquid outlet flow channel, and enters the reaction pool 105b-5 of the detection chamber 105b-6 through the reaction liquid discharge hole 105b-4, and the saliva After the liquid discharge is completed, the second electromagnet 508 is turned off, and the first metal sheet 507 moves down to separate the first liquid inlet portion 506a from the inner cavity of the first storage case 506 again;

(2) The reaction liquid control motor 501 operates, the liquid injection pipe 503 rotates, so that the liquid injection pipe 503 rotates to align with the position of the next second liquid inlet part 504a, the reaction liquid control motor 501 stops, and the second electromagnet 508 starts , the second metal sheet 505 moves upwards to open, the first pump 502 is started, and the detergent in the second storage case 504 is sucked, and the detergent flows into the reaction pool 105b-5 to remove unbound samples, and the second electromagnet 508 is closed , the first liquid suction pump 502 is turned off, the second liquid suction pump 510 is turned on, and the excess waste liquid is pumped into the waste liquid pool;

(3) The reaction liquid control motor 501 operates, aligning the liquid injection pipe 503 with the next second liquid inlet 504a, the reaction liquid control motor 501 stops, the second electromagnet 508 is activated, and the second metal sheet 505 moves up and opens. The first liquid pump 502 is activated to absorb the biotin-modified antibody contained in the biotin-modified second storage shell 504, and the biotin-modified antibody enters the transferrin detection chamber 105b-6 at the head end for incubation, and the incubation is completed. The second electromagnet 508 and the first liquid suction pump 502 are closed, the second metal sheet 505 moves down, the second liquid suction pump 510 is turned on, and excess waste liquid is drawn into the waste liquid pool;

(4) The reaction liquid control motor 501 operates, the liquid injection pipe 503 rotates, so that the liquid injection pipe 503 rotates to align with the position of the next second liquid inlet part 504a, the reaction liquid control motor 501 stops, and the second electromagnet 508 starts , the second metal sheet 505 is moved up and opened, the first pump 502 is started, and the detergent in the second storage case 504 is sucked, and the detergent flows into the reaction pool 105b-5 to remove excess biotin antibody, and the second electromagnet 508 is closed, the first liquid suction pump 502 is closed, the second liquid suction pump 510 is opened, and excess waste liquid is drawn into the waste liquid pool;

(5) The reaction liquid control motor 501 operates, the liquid injection pipe 503 rotates, so that the liquid injection pipe 503 rotates to align with the position of the next second liquid inlet part 504a, the reaction liquid control motor 501 stops, and the second electromagnet 508 starts , the second metal sheet 505 is moved up and opened, the first liquid pump 502 is started, and the reaction liquid containing avidin-labeled horseradish peroxidase in the second storage case 504 is sucked, and the reaction liquid containing avidin-labeled horseradish peroxidase is sucked. The oxidase reaction liquid flows into the reaction tank 105b-5, and the reaction is completed, the second electromagnet 508 is closed, the first liquid pump 502 is closed, the second liquid pump 510 is opened, and excess waste liquid is drawn into the waste liquid pool;

(6) The reaction liquid control motor 501 operates, the liquid injection pipe 503 rotates, so that the liquid injection pipe 503 rotates to align with the position of the next second liquid inlet part 504a, the reaction liquid control motor 501 stops, and the second electromagnet 508 starts , the second metal sheet 505 is moved up and opened, the first pump 502 is started, and the reaction solution containing the tetramethylbenzidine substrate in the second storage case 504 is sucked, and the reaction solution containing the tetramethylbenzidine substrate flows into the reaction pool In 105b-5, a color reaction occurs, the reaction ends, the second electromagnet 508 is turned off, the first liquid pump 502 is turned off, the second liquid pump 510 is turned on, and excess waste liquid is pumped into the waste liquid pool;

(7) The reaction liquid control motor 501 operates, the liquid injection pipe 503 rotates, so that the liquid injection pipe 503 rotates to the position where the second liquid inlet part 504a is aligned with the end, the reaction liquid control motor 501 stops, and the second electromagnet 508 starts , the second metal sheet 505 is moved up and opened, the first liquid suction pump 502 is started, and the stop liquid in the second storage case 504 is sucked, the stop liquid flows into the reaction pool 105b-5, and the color reaction is terminated, and the reaction is completed, and the second electromagnetic The iron 508 is closed, the first liquid suction pump 502 is closed, the second liquid suction pump 510 is opened, and excess waste liquid is drawn into the waste liquid pool;

(8) Place a light source facing the second detection slot 600 on the lower side of the first chip body 105 , insert a colorimetric camera in the second detection slot 600 , and the colorimetric camera captures the color development to realize the detection of transferrin in saliva.

The present invention realizes the detection of different proteins in saliva through the arrangement of the second reaction component 500 and the liquid inlet component 300 .

It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention without limitation, although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be carried out Modifications or equivalent replacements without departing from the spirit and scope of the technical solution of the present invention shall be covered by the claims of the present invention.

Claims (10)

1. A chip capable of simultaneously detecting multiple body fluids, characterized in that: it comprises A chip component (100), a first detection groove (106) is opened at one end of the chip component (100), a first installation channel (408) is provided in the chip component (100), and one end of the first installation channel (408) A number of liquid inlet channels are arranged on the chip assembly (100), and a number of installation grooves (107) are arranged on the chip assembly (100); The liquid inlet assembly (300), the liquid inlet assembly (300) is provided with several groups and corresponds to the installation groove (107) one by one, and the liquid inlet assembly (300) is installed in the corresponding installation groove (107); The first reaction assembly (400), the first reaction assembly (400) includes a centralized injection seat (401) fixed in the chip assembly (100) and installed at one end of the first installation channel (408), the centralized injection seat One end of (401) is arranged with a number of concentrated injection ports (401a) connected with the liquid inlet channel, and the other end of the centralized injection seat (401) is connected with a dispersed injection seat (402), and the dispersed injection seat (402) is relatively centralized One end of the injection seat (401) is provided with a first liquid outlet (401b), a second liquid outlet (401c), a third liquid outlet (401d) and a fourth liquid outlet (401e) which are independent of each other. The end of the seat (402) away from the concentrated injection seat (401) is arranged with a number of first liquid outlets (402b) communicating with the first liquid outlet tank (401b), and a second liquid outlet port (401c) communicating with the second liquid outlet tank (401c). The liquid outlet (402c), the third liquid outlet (402e) connected to the third liquid outlet (401d), and the fourth liquid outlet (402g) connected to the fourth liquid outlet (401e), the first installation A rotating ring (406) is rotatably connected to the chip assembly (100) at the other end of the channel (408), and a guide shaft (404) is fixedly connected to the end of the dispersed injection seat (402) away from the concentrated injection seat (401), The end of the guide shaft (404) away from the dispersing injection seat (402) is fixedly connected in the chip assembly (100), and the guide shaft (404) is slidably connected with a magnetic control and can be inserted into the rotating ring (406). The reaction ring (403) on the top of the reaction ring (403) is arranged with a number of injection pipes (410) corresponding to each liquid outlet and controlled by magnetic force. The side of the injection pipe (410) is opened with The first inflow injection port (410a) and the second inflow injection port (410b) are arranged at intervals in the axial direction, the first electromagnet (409) is connected to the chip component (100) at the first detection slot (106), and the A plurality of reaction liquid storage pools (403c) corresponding to the injection pipes (410) are arranged in the reaction ring (403), and the magnetism of the reaction ring (403) is smaller than that of the injection pipe (410). 2. The chip capable of detecting multiple body fluids at the same time according to claim 1, characterized in that: the reaction ring (403) on the side opposite to the injection tube (410) of the reaction liquid storage pool (403c) is provided with a seal An injection chamber (403a) is formed between the opening (403b), the closed opening (403b) and the inner wall of the reaction ring (403) away from the end of the reaction solution storage pool (403c), and the injection pipe (410) is away from the dispersion injection seat (402 ) is provided with a sealing part (410c) at one end, the sealing part (410c) can just block the sealing port (403b), and the first inflow and injection port (410a) of the injection pipe (410) is at the corresponding first liquid outlet (402b), the second inflow injection port (410b) is in the injection chamber (403a). 3. The chip capable of detecting multiple body fluids at the same time according to claim 1, characterized in that: the liquid inlet component (300) includes a vertically connected in the corresponding installation sink (105h) and has an upward opening The liquid inlet housing (301a), the pressure plate is slidably connected to the liquid inlet housing (301a), and the center of the liquid inlet housing (301a) is fixedly connected with a central shaft (301c), and the central shaft (301c) protrudes upwards One end of the liquid inlet casing (301a) is fixedly connected with a fixed ring (301b), and at least two linear drives (301d) are arranged on the fixed ring (301b), and the linear drive (301d) is connected with A telescopic rod (301h) for reciprocating linear movement, the lower end of the telescopic rod (301h) is connected to the upper side of the pressure plate, the central axis (301c) is provided with an upward sinking hole for the liquid, and the middle shaft under the pressure plate A liquid inlet (301c-1) is opened on the side of the shaft (301c), and a liquid inlet chamber is formed between the lower side of the pressure plate and the inner wall of the liquid inlet housing (301a). 4. The chip capable of simultaneously detecting multiple body fluids according to any one of claims 1 to 3, characterized in that it further comprises a second reaction component (500), and a second reaction component (500) is provided in the chip component (100). The installation channel, the second reaction assembly (500) includes a first storage shell (506) and several second storage shells (504) connected in the second installation channel, the chip assembly (100) is equipped with a vertical The reaction liquid flow channel is set, the inner cavity of the first storage shell (506) can communicate with the reaction liquid flow channel, and the inner cavity of the second storage shell (504) can communicate with the reaction liquid flow channel, The inner chamber of the first storage shell (506) can communicate with the liquid inlet chamber of one of the liquid inlet components (300), and the chip component (100) is also provided with several groups of reaction units connected end to end. The unit includes a first reaction channel, one end of the first reaction channel in the reaction unit at the head end communicates with the reaction liquid flow channel, the other end of the first reaction channel is connected to one end of the second reaction channel, and the other end of the second reaction channel is connected to the reaction channel. One end of the third reaction channel is connected, and in two adjacent reaction units, the other end of the previous third reaction channel is connected with one end of the next first reaction channel. 5. The chip capable of simultaneously detecting multiple body fluids according to claim 4, characterized in that: the chip component (100) is fixedly connected with a reaction liquid control motor (501), and the reaction liquid control motor (501) A liquid injection tube (503) protruding downwards is connected to the top, and the side of the first storage shell (506) opposite to the liquid injection tube (503) is provided with a first liquid inlet part (506a), and the second The side of the storage shell (504) opposite to the liquid injection tube (503) is provided with a second liquid inlet part (504a), and one end of the liquid injection tube (503) can be attached to the outside of the first liquid inlet part (506a) And aligned with the first liquid inlet part (506a) or attached to the outside of the second liquid inlet part (504a) and aligned with the second liquid inlet part (504a), the other end of the liquid injection tube (503) is fixedly connected with The first liquid suction pump (502), the lower end of the liquid injection pipe (503) is connected to the upper end of the reaction liquid flow channel. 6. The chip capable of simultaneously detecting multiple body fluids as claimed in claim 4, characterized in that: the first reaction channel and the second reaction channel are arranged in parallel, and the chip assembly between the first reaction channel and the second reaction channel There are several reaction pools (105b-5) arranged in (100), and the chip assembly (100) on the side of the first reaction channel and the third reaction channel facing the reaction pool (105b-5) has a reaction solution drain hole (105b-4). 7. The chip capable of simultaneously detecting multiple body fluids according to claim 4, characterized in that: the chip component (100) at the other end of the third reaction channel in the terminal reaction unit is provided with a waste liquid outlet channel, the The chip component (100) is provided with a waste liquid pool, and the end of the waste liquid outlet channel away from the end of the third reaction channel is connected to the waste liquid pool. 8. The chip capable of simultaneously detecting multiple body fluids according to claim 7, characterized in that: a second pump (510) is connected to the chip assembly (100) at the end of the waste liquid pool away from the reaction unit. 9. The chip capable of simultaneously detecting multiple body fluids according to claim 5, characterized in that: the chip assembly (100) includes a first chip body (105), a second chip body (104) and the third chip body, the first chip body (105) has a mounting sinker (105h) on the upward side, and the second chip body (104) has a mounting sinker (105h) ) corresponding to the installation port (104c), the installation sinker (105h) and the installation port (104c) form the first installation channel (408), and the third chip body (103) connects the first installation channel (408 ) closed, the upward side of the first chip body (105) is arranged with several groups of lower reaction units (105b) connected end to end, and the lower reaction units (105b) include first The lower reaction liquid flow channel (105b-3), the second lower reaction liquid flow channel (105b-2) and the third lower reaction liquid flow channel (105b-1), the second chip body (104) is arranged at the end facing downward There are several groups of upper reaction units (104b) connected end to end, and the upper reaction units (104b) include sequentially connected to the first upper reaction liquid flow channel (104b-2), the second upper reaction liquid flow channel (104b-1 ) and the third lower reaction liquid flow channel (105b-1), and the upper and lower ends are closed between the first lower reaction liquid flow channel (105b-3) and the corresponding first upper reaction liquid flow channel (104b-2) The first reaction channel, the second reaction channel with closed upper and lower ends is formed between the second lower reaction liquid flow channel (105b-2) and the corresponding second upper reaction liquid flow channel (104b-1). A third reaction channel with its upper and lower ends closed is formed between the three lower reaction liquid flow channels (105b-1) and the corresponding third upper reaction liquid flow channel (104b-3). 10. The chip capable of simultaneously detecting multiple body fluids according to any one of claims 1 to 3, characterized in that: a drive motor (405) is fixedly connected to the first installation channel (408) of the chip assembly (100) , the transmission motor (405) is connected via a transmission belt (407) and a rotating ring (406).