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CN114983877B - Essential oil hand sanitizer and preparation method thereof - Google Patents

Essential oil hand sanitizer and preparation method thereof Download PDF

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CN114983877B
CN114983877B CN202210777401.2A CN202210777401A CN114983877B CN 114983877 B CN114983877 B CN 114983877B CN 202210777401 A CN202210777401 A CN 202210777401A CN 114983877 B CN114983877 B CN 114983877B
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oil
hand sanitizer
poloxamer
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CN114983877A (en
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陈萌
傅建越
周思雨
金志敏
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Zhejiang University of Technology ZJUT
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Communicable Diseases (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

According to the invention, eucalyptus essential oil and sweet wormwood oil are added into the hand sanitizer at the same time, PVPk32, poloxamer 407 and decaglycerol are used as emulsifying agents, so that antibacterial components of the hand sanitizer are improved, the antibacterial rate of the hand sanitizer is improved, and the purposes of effectively improving the sanitation, health and skin care standards of the hand sanitizer are achieved. The method has no scientific report at present, and no information about using the technology in production.

Description

一种精油洗手液及其制备方法Essential oil hand sanitizer and preparation method thereof

技术领域Technical field

本发明涉及日常用品技术领域,涉及一种精油洗手液及其制备方法。The invention relates to the technical field of daily necessities, and relates to an essential oil hand sanitizer and a preparation method thereof.

技术背景technical background

目前的洗手液成分中通常会采用一定量的化学成分来作为洗手液的抑菌成分,使用这些洗手液也只是清除手部皮肤表层的细菌和污垢,不能起到持久抑菌的功效,这就是目前市场上洗手液存在的不足。随着社会的进步和发展,人们的日常生活水平不断提高,对细节用品的要求也越来越高,在使用洗手液的过程中,人们不仅要求能够除污去垢,还希望具有长的除菌抑菌功能。Current hand sanitizers usually use a certain amount of chemical components as the antibacterial ingredients of hand sanitizers. Using these hand sanitizers only removes bacteria and dirt on the surface of the skin of the hands, and cannot achieve a long-lasting antibacterial effect. This is The shortcomings of hand sanitizers currently on the market. With the progress and development of society, people's daily living standards continue to improve, and their requirements for detailed supplies are getting higher and higher. In the process of using hand sanitizer, people not only require it to be able to remove dirt and scale, but also hope to have a long-lasting cleaning effect. Antibacterial function.

洗手液主要的功能是起到清洁护肤的作用,有些特定的成分可以起到消毒、杀菌的作用,比如大肠杆菌、金黄色葡萄球菌、链球菌属等,不过假冒产品洗了反而对手部皮肤损伤较大。洗手液分为多种,如:普通洗手液,只具备清洁去污的作用;消毒洗手液,抗具有菌、抑菌或杀菌的功效;重油污洗手液,针对工业类油污(机油、汽油、黄油、柴油等)和顽固污渍的清洗。The main function of hand sanitizer is to clean and protect skin. Some specific ingredients can disinfect and sterilize, such as Escherichia coli, Staphylococcus aureus, Streptococcus, etc. However, counterfeit products can cause damage to the skin of the hands after washing. larger. There are many types of hand sanitizers, such as: ordinary hand sanitizer, which only has the function of cleaning and decontamination; disinfectant hand sanitizer, which has antibacterial, bacteriostatic or sterilizing effects; heavy oil stain hand sanitizer, which is used for industrial oil stains (machine oil, gasoline, Butter, diesel, etc.) and stubborn stains.

洗手液是直接面对皮肤的,它直接涂在皮肤上,所以pH有更高要求,不能是碱性的,也不能是酸性的。另外,洗手液一般无磷、铝、碱、烷基苯磺酸钠等成分。Hand sanitizer directly faces the skin and is applied directly to the skin, so the pH has higher requirements and cannot be alkaline or acidic. In addition, hand sanitizers generally do not contain phosphorus, aluminum, alkali, sodium alkyl benzene sulfonate and other ingredients.

某些中药成分通过增加细菌的导电率,改变细菌细胞膜蛋白质的结构进而改变细菌细胞膜的通透性,破坏细菌细胞壁结构,可抑制细菌细胞膜的形成并提高细菌对抑菌抗菌成分的敏感性,然后抑制菌体呼吸代谢,抑制病原菌的粘附达到抗菌抑菌的目的。采用纯植物提取成分,无需额外添加防腐剂,天然环保,安全无刺激、无毒副作用,在保证抑菌抗菌活性的同时,可保证洗手液自身的稳定性,且具有很好的保湿吸湿效果。Certain traditional Chinese medicine ingredients can inhibit the formation of bacterial cell membranes and increase the sensitivity of bacteria to antibacterial and antibacterial ingredients by increasing the conductivity of bacteria, changing the structure of bacterial cell membrane proteins, thereby changing the permeability of bacterial cell membranes, and destroying bacterial cell wall structures. Inhibit bacterial respiratory metabolism and inhibit the adhesion of pathogenic bacteria to achieve antibacterial and bacteriostatic purposes. It uses pure plant-derived ingredients without adding additional preservatives. It is natural and environmentally friendly, safe, non-irritating, and has no toxic side effects. It not only ensures the antibacterial and antibacterial activity, but also ensures the stability of the hand sanitizer itself, and has a good moisturizing and moisture-absorbing effect.

桉叶是中国南方常用的中草药,桉叶油具有抗菌、抗炎、抗氧化和局部麻醉等作用。桉叶挥发油主要成分为3-蒈烯、α-松油醇、(-)蓝桉醇、D-萜二烯、1-松香芹醇等,可用于治疗流行性感冒、上呼吸道感染、肺炎、咳嗽及皮肤疾病。青蒿油具有抗菌、抗癌,抗病毒,抗炎,驱蚊,杀虫,抗氧化等活性。Eucalyptus leaf is a commonly used Chinese herbal medicine in southern China. Eucalyptus leaf oil has antibacterial, anti-inflammatory, antioxidant and local anesthetic effects. The main components of eucalyptus leaf volatile oil are 3-carene, α-terpineol, (-)glomerol, D-terpene, 1-terpineol, etc., which can be used to treat influenza, upper respiratory tract infections, pneumonia, Coughs and skin diseases. Artemisia annua oil has antibacterial, anticancer, antiviral, anti-inflammatory, mosquito repellent, insecticidal, antioxidant and other activities.

本发明将桉叶精油和青蒿油同时添加到洗手液中,将聚乙烯吡咯烷酮k32(以下简称为PVPk32)、泊洛沙姆407、十聚甘油作为乳化剂,因泊洛沙姆407收敛皮肤的功效,以此改善洗手液的抑菌效果,提高洗手液的抑菌率,从而有效提高洗手液的卫生、健康、护肤的目的。此种方法目前尚无科研报道,也没有生产中使用此类技术的信息。In the present invention, eucalyptus essential oil and artemisia annua oil are added to the hand sanitizer at the same time, and polyvinylpyrrolidone k32 (hereinafter referred to as PVPk32), poloxamer 407, and decaglycerol are used as emulsifiers, so that poloxamer 407 astringes the skin. In order to improve the antibacterial effect of hand sanitizer and increase the antibacterial rate of hand sanitizer, it can effectively improve the hygiene, health and skin care purposes of hand sanitizer. There are currently no scientific research reports on this method, and there is no information on the use of such technology in production.

发明内容Contents of the invention

本发明主要提供了一种精油洗手液及其制备方法,用以解决上述背景技术中提出的技术问题。The present invention mainly provides an essential oil hand sanitizer and a preparation method thereof to solve the technical problems raised in the above background technology.

本发明解决上述技术问题采用的技术方案为:The technical solutions adopted by the present invention to solve the above technical problems are:

一种精油洗手液及其制备方法,其特征在于,按重量份计,由以下成分组成:桉叶油1-6份,青蒿油1-6份,PVPk321-4份,泊洛沙姆4071-6份,十聚甘油1-4份,水100-400份。An essential oil hand sanitizer and its preparation method, characterized in that it consists of the following ingredients in parts by weight: 1-6 parts of eucalyptus oil, 1-6 parts of artemisia annua oil, 321-4 parts of PVPk, and poloxamer 4071 -6 parts, 1-4 parts of polyglycerol, 100-400 parts of water.

优选的,桉叶油3份,青蒿油3份,PVPk32 1份,泊洛沙姆407 1份,十聚甘油1份,水150份。Preferably, 3 parts of eucalyptus oil, 3 parts of artemisia annua oil, 1 part of PVPk32, 1 part of poloxamer 407, 1 part of decalycerol, and 150 parts of water.

本发明所用水均为去离子水。The water used in the present invention is all deionized water.

桉叶油与青蒿油有协同杀菌作用,泊洛沙姆407的加入作为乳化剂,同时杀菌作用增强。本发明所用的乳化剂为PVPk32、泊洛沙姆407、十聚甘油,这三种联合使用作为乳化剂是本发明首创,作为乳化剂的同时,泊洛沙姆407也有收敛作用,配合桉叶及青蒿油使用杀菌效果更佳。Eucalyptus oil and Artemisia annua oil have a synergistic bactericidal effect. The addition of poloxamer 407 as an emulsifier also enhances the bactericidal effect. The emulsifiers used in the present invention are PVPk32, poloxamer 407, and decapolyglycerol. The combined use of these three as emulsifiers is the first invention of the present invention. While serving as an emulsifier, poloxamer 407 also has an astringent effect. Together with eucalyptus The sterilization effect is better when used with Artemisia annua oil.

具体实施方式Detailed ways

1.按表1重量份称取桉叶油,青蒿油,PVPk32,泊洛沙姆407,十聚甘油,水。1. Weigh the eucalyptus oil, artemisia annua oil, PVPk32, poloxamer 407, ten polyglycerol and water according to the weight parts in Table 1.

2.在混合釜中,先加入水,加热至70-80℃,在搅拌条件下,再加入PVPk32、泊洛沙姆407、十聚甘油,降温至30-40℃,再加入桉叶油和青蒿油,搅拌均匀,即可得到本发明的精油洗手液。2. In the mixing kettle, first add water and heat to 70-80°C. Under stirring conditions, add PVPk32, poloxamer 407 and decapolyglycerol, cool to 30-40°C, then add eucalyptus oil and Artemisia annua oil, stir evenly to obtain the essential oil hand sanitizer of the present invention.

表1 各实施例、对比例配方(重量份)Table 1 Formulas of various examples and comparative examples (parts by weight)

由表1可见,实施例1至5,以及对比例1与2,得到乳液放置2年不分层。而未加入PVPk32或者泊洛沙姆407对比例3与4得到的乳液不稳定,分别放置1天和15天即分层;未加任何乳化剂的对比例5则油水分层。It can be seen from Table 1 that the emulsions obtained in Examples 1 to 5 and Comparative Examples 1 and 2 did not stratify after being placed for 2 years. The emulsions obtained in Comparative Examples 3 and 4 without adding PVPk32 or Poloxamer 407 were unstable and separated after 1 day and 15 days respectively. Comparative Example 5 without adding any emulsifier separated into oil and water.

抑菌效果测试Antibacterial effect test

按照行业标准QB/T2850-2007抗菌抑菌型洗涤剂,进行抑菌效果测试,作用浓度均为1wt%,作用时间均为15分钟,具体检测数据,详见表2。In accordance with the industry standard QB/T2850-2007 antibacterial and bacteriostatic detergents, the antibacterial effect was tested. The action concentration was 1wt% and the action time was 15 minutes. The specific test data are shown in Table 2.

表2 精油洗手液抑菌效果测试表Table 2 Antibacterial effect test table of essential oil hand sanitizer

由表2可见,实施例与对比例比较,由于实施例1-5中加入桉叶油和青蒿油,而对比例1、2中只加入一种精油,对比例3-5中只加入其中一种或未加入泊洛沙姆407,实施例杀菌效果较对比例好。桉叶油与青蒿油有协同杀菌作用,泊洛沙姆407的加入作为乳化剂。It can be seen from Table 2 that compared with the comparative examples, since eucalyptus oil and artemisia annua oil were added in Examples 1-5, only one essential oil was added in Comparative Examples 1 and 2, and only one of them was added in Comparative Examples 3-5. Either or without adding poloxamer 407, the bactericidal effect of the embodiment is better than that of the comparative example. Eucalyptus oil and Artemisia annua oil have a synergistic bactericidal effect, and poloxamer 407 is added as an emulsifier.

Claims (2)

1.一种精油洗手液,其特征在于,按重量份计,由以下成分组成:桉叶油1-6份,青蒿油1-6份,PVPk321-4份,泊洛沙姆4071-6份,十聚甘油1-4份,水100-400份;1. An essential oil hand sanitizer, characterized in that, by weight, it consists of the following ingredients: 1-6 parts of eucalyptus oil, 1-6 parts of Artemisia annua oil, 321-4 parts of PVPk, and 4071-6 poloxamer. parts, 1-4 parts of polyglycerol, 100-400 parts of water; 所述精油洗手液的制备方法:The preparation method of the essential oil hand sanitizer: (1)按重量份数取桉叶油1-6份,青蒿油1-6份,PVPk321-4份,泊洛沙姆4071-6份,十聚甘油1-4份,水100-400份;(1) According to parts by weight, take 1-6 parts of eucalyptus oil, 1-6 parts of Artemisia annua oil, 321-4 parts of PVPk, 4071-6 parts of poloxamer, 1-4 parts of decaglycerol, and 100-400 parts of water. share; (2)在混合釜中,先加入水,加热至70-80℃,在搅拌条件下,再加入PVPk32、泊洛沙姆407、十聚甘油,降温至30-40℃,再加入桉叶油和青蒿油,搅拌均匀,即可得到精油洗手液。(2) In the mixing kettle, first add water, heat to 70-80°C, then add PVPk32, poloxamer 407, and decaglycerol under stirring conditions, cool to 30-40°C, and then add eucalyptus oil and artemisia annua oil, stir evenly to get essential oil hand sanitizer. 2.如权利要求1所述的一种精油洗手液,其特征在于,按重量份计,由以下成分组成:桉叶油3份,青蒿油3份,PVPk321份,泊洛沙姆4071份,十聚甘油1份,水150份。2. A kind of essential oil hand sanitizer as claimed in claim 1, characterized in that, by weight, it is composed of the following ingredients: 3 parts of eucalyptus oil, 3 parts of artemisia annua oil, 321 parts of PVPk, and 4071 parts of poloxamer. , 1 part of ten polyglycerol, 150 parts of water.
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* Cited by examiner, † Cited by third party
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