CN114949720B - A method and system for treating antibiotic residue - Google Patents

Abstract

The embodiment of the invention provides a method and a system for preparing antibiotic residues, wherein calcium peroxide is dissolved in antibiotic residues with higher water content, and generated calcium ions can replace hydrogen ions of acidic proteins under the acidic condition of the antibiotic residues to form insoluble protein-calcium precipitates, so that the proteins are coagulated, the competition of the proteins and antibiotics on hydroxyl free radicals generated by irradiation is eliminated, the number of hydroxyl free radicals reacted with the antibiotics in an irradiation system is obviously increased, and the pollution of antibiotics in the antibiotic residues is thoroughly eliminated. According to the embodiment of the invention, under the synergistic interaction of electron beam irradiation and calcium peroxide, the antibiotics in the antibiotic residues can be completely degraded, so that the concentration of the antibiotics can not be detected by liquid chromatography, namely the antibiotic removal rate can reach 100%. In the method provided by the embodiment of the invention, electron beam irradiation is performed at normal temperature, so that large-scale industrial application is easy to realize.

Description

A method and system for treating antibiotic residue

technical field

The embodiments of the present invention relate to the field of solid waste treatment, in particular to a method and system for treating antibiotic residues.

Background technique

Cephalosporin antibiotics are currently one of the most widely used broad-spectrum antibiotics, and cephalosporin C (CPC) is the main raw material drug of cephalosporin antibiotics. CPC is produced by aerobic fermentation using Cephalosporium acremonium as the fermentation strain and using corn steep liquor, peanut cake powder, dextrin, methionine, soybean oil, inorganic salts, etc. as the medium. After the fermentation process is completed, sulfuric acid is added to the fermentation broth to acidify the mycelia and protein to precipitate, and the supernatant is filtered through a ceramic membrane to remove macromolecular protein substances, and then undergoes processes such as resin adsorption purification and concentration to obtain the final raw material drug product. The precipitate acidified by sulfuric acid and the concentrate separated by the ceramic membrane are antibiotic residue waste, and its main components are residual mycelium, culture medium and antibiotics.

Antibiotic bacteria residue is rich in nutrition, rich in polysaccharides, proteins, various amino acids and trace elements, etc., and the protein content can reach more than 30%. Residual antibiotics are the source of pollution in antibiotic residues. If they can be removed from antibiotic residues, it is expected that antibiotic residues will be removed from hazardous waste. Harmless antibiotic residues can be made into fertilizers and reused as resources, thereby solving the problem of antibiotic residues treatment and disposal.

Antibiotic residue is a viscous solid-liquid mixture, and the usual treatment methods such as ultraviolet light and photocatalysis are difficult to penetrate and react inside the residue, and the removal rate of antibiotics is not high.

Therefore, there is an urgent need for a high-removal antibiotic residue treatment method.

Contents of the invention

The embodiments of the present invention provide a method and system for treating antibiotic residues, so as to degrade antibiotics in antibiotic residues, so that the concentration of antibiotics in antibiotic residues can be reduced to undetectable by liquid chromatography.

The first aspect of the embodiments of the present invention provides a method for antibiotic scum, said method comprising:

Mix antibiotic scum with calcium peroxide to obtain a mixture;

irradiating the mixture with an electron beam to degrade the antibiotics in the antibiotic residue;

Wherein, the calcium peroxide dissolves to generate calcium ions, and under the acidic condition of the antibiotic residue, the calcium ion replaces the hydrogen ion of the acidic protein to form an insoluble protein-calcium precipitate, coagulates the protein, eliminates the competition effect of the protein on the hydroxyl radicals produced by electron beam irradiation, increases the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthens electron beam irradiation to degrade antibiotics in antibiotic residues.

Optionally, the antibiotic scum is mixed with calcium peroxide to obtain a mixture, including:

Adding calcium peroxide to the antibiotic residue, mixing the antibiotic residue with the calcium peroxide to obtain a mixture;

The mixture is irradiated with an electron beam, comprising:

The mixture is sent to an irradiation chamber of an electron accelerator, and the mixture is irradiated with an electron beam.

Optionally, the antibiotic residue is cephalosporin fermentation residue containing residual antibiotic produced during antibiotic production, and the antibiotic is cephalosporin C.

Optionally, the residual cephalosporin C content in the cephalosporin fermentation residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation residue is 85%-95%.

Optionally, the radiation absorbed dose of the electron beam is 40kGy-75kGy.

Optionally, the dosage of the calcium peroxide is 0.04mM-0.1mM.

The second aspect of the embodiment of the present invention provides an antibiotic residue system, which is used to implement the antibiotic residue treatment method described in any one of the above first aspects, the system comprising:

The reactor is used to hold the antibiotic residue for processing the antibiotic residue;

Calcium peroxide dosing device, used to add calcium peroxide to the reactor;

A stirring device for mixing the antibiotic residue and the calcium peroxide to obtain a mixture;

An electron accelerator for generating an electron beam to irradiate the mixture to degrade the antibiotic in the antibiotic residue;

Wherein, the calcium peroxide dissolves to generate calcium ions, and under the acidic condition of the antibiotic residue, the calcium ion replaces the hydrogen ion of the acidic protein to form an insoluble protein-calcium precipitate, coagulates the protein, eliminates the competition effect of the protein on the hydroxyl radicals produced by electron beam irradiation, increases the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthens electron beam irradiation to degrade antibiotics in antibiotic residues.

Optionally, the antibiotic residue is cephalosporin fermentation residue containing residual antibiotics produced in the antibiotic production process, the antibiotic is cephalosporin C, the residual cephalosporin C content in the cephalosporin fermentation residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation residue is 85%-95%.

Optionally, the radiation absorbed dose of the electron beam is 40kGy-75kGy.

Optionally, the dosage of the calcium peroxide is 0.04mM-0.1mM.

In the antibiotic slag method that the embodiment of the present invention provides, the radiation effect of the electron beam and the acidic environment (pH value is usually about 4.0) of the antibiotic slag are conducive to the in-situ decomposition of calcium peroxide to produce hydrogen peroxide, and the e produced by hydrogen peroxide and irradiation_aqThe - and H reaction promotes the production of OH; at the same time, the calcium ions produced by the dissolution of calcium peroxide can replace the hydrogen ions of the acidic protein under the strong acidic conditions of the antibiotic slag, forming insoluble protein-calcium precipitates to coagulate the protein, thereby eliminating its competition with the antibiotics for the hydroxyl radicals produced by irradiation, and significantly increasing the number of hydroxyl radicals reacting with the antibiotics in the irradiation system, thereby completely eliminating antibiotic pollution in the antibiotic slag.

In the embodiment of the present invention, under the synergistic interaction between electron beam irradiation and calcium peroxide, the antibiotics in the antibiotic residue can be completely degraded, and the concentration of antibiotics can be reduced to undetectable by liquid chromatography, that is, the removal rate of antibiotics can reach 100%. In the method provided by the embodiment of the present invention, electron beam irradiation is carried out at normal temperature, which is easy to realize large-scale industrial application. It can be seen that the method provided by the implementation of the present invention is efficient, convenient, and widely applicable, can be applied to the treatment of antibiotic bacteria residues, and has broad application prospects in the field of hazardous solid waste treatment.

Description of drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the accompanying drawings used in the description of the embodiments of the present invention. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained according to these drawings without paying creative labor.

Fig. 1 is the flowchart of a kind of antibiotic bacterium residue method of the embodiment of the present invention;

Fig. 2 is the flowchart of another kind of antibiotic slag method of the embodiment of the present invention;

Fig. 3 is a schematic diagram of an antibiotic residue system according to an embodiment of the present invention.

Detailed ways

In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

Electron beam irradiation technology uses electron beams generated by electron accelerators to treat pollutants. The electron beam is a dense high-speed electron flow with extremely high energy density. The high-energy electron beam can penetrate deep into the bacterial residue and directly destroy the molecular structure of the antibiotic through the Compton effect; at the same time, the electron beam can excite the ionization of water molecules to generate active particles such as OH, e _aq -, H, etc. (as shown in formula 1, the values in brackets are the radiation chemical yield of each active particle), and the antibiotic can be degraded by oxidation-reduction reaction with these active particles.

During the treatment of antibiotic residues by electron beam irradiation, when the absorbed dose is 40kGy, the removal rate of antibiotics can reach more than 90%. But continue to increase the dose, the increase in the removal rate of antibiotics is not large, and the ideal removal rate cannot be achieved.

In related technologies, the commonly used method is to use oxidants to strengthen electron beam irradiation to degrade antibiotics in bacterial residues to generate more strong oxidizing OH, promote oxidation-reduction reactions, and then promote the degradation of antibiotics. However, this method still cannot achieve the effect of reducing the concentration of antibiotics to a level that cannot be detected by liquid chromatography, and cannot achieve an ideal removal rate.

Therefore, the inventor explored the treatment method of antibiotic residue, and the inventor found that the protein, polysaccharide and other substances present in the antibiotic residue solution competed with the antibiotic for the free radicals generated by irradiation, thus limiting the further degradation of the antibiotic. The lower the concentration of antibiotics, the stronger the competition of these substances and the greater the impact on antibiotic degradation. Among them, the irradiation competition of protein is the strongest. In order to completely eliminate the antibiotic pollution, it is necessary to inhibit the irradiation competition of protein.

Based on the above findings, the inventive concept of the present application is proposed: use calcium peroxide to strengthen electron beam irradiation to degrade antibiotics in bacterial residues, wherein the calcium peroxide dissolves in antibiotic residues with higher water content to generate calcium ions, and under the acidic conditions of antibiotic residues, calcium ions replace hydrogen ions of acidic proteins to form insoluble protein-calcium precipitates to coagulate proteins, eliminate the competition of proteins to hydroxyl radicals produced by electron beam irradiation, increase the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthen electron beam irradiation to degrade antibiotic residues. antibiotics in.

Based on above-mentioned inventive concept, the first aspect of the present invention proposes a kind of antibiotic scum treatment method, below in conjunction with accompanying drawing 1 a kind of antibiotic scum treatment method that the present invention proposes is illustrated, and this method comprises the following steps:

S101, mixing antibiotic residues with calcium peroxide to obtain a mixture.

In the embodiment of the present invention, any feasible method in the related art can be used to mix the antibiotic residue and calcium peroxide, which is not specifically limited in the embodiment of the present invention.

S102. Using electron beams to irradiate the mixture to degrade the antibiotics in the antibiotic residues.

In the embodiment of the present invention, any feasible method in the related art may be used to irradiate the mixture with electron beams, which is not specifically limited in the embodiment of the present invention.

In the embodiment of the present invention, calcium peroxide is dissolved in the antibiotic slag with high water content to generate calcium ions. Under the acidic conditions of the antibiotic slag, the calcium ions replace the hydrogen ions of the acidic protein to form insoluble protein-calcium precipitates, coagulate the protein, eliminate the competition effect of the protein on the hydroxyl radicals produced by electron beam irradiation, increase the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthen the electron beam irradiation to degrade the antibiotics in the antibiotic slag.

In the embodiment of the present invention, the radiation effect of the electron beam and the acidic environment of the antibiotic slag cause calcium peroxide to decompose in situ to generate hydrogen peroxide, and the reaction between hydrogen peroxide and e _aq- and H produced by electron beam irradiation promotes the generation of OH, and the degradation of antibiotics in the antibiotic slag by electron beam irradiation can be further strengthened by promoting the oxidation-reduction reaction.

Based on above-mentioned inventive concept, the present invention also proposes another kind of antibiotic scum treatment method, below in conjunction with accompanying drawing 2 another kind of antibiotic scum treatment method that the present invention proposes is illustrated, and this method comprises the following steps:

S201, adding calcium peroxide to the antibiotic residue, and mixing the antibiotic residue with the calcium peroxide to obtain a mixture.

In the embodiment of the present invention, the calcium peroxide may be powdery solid, so as to be evenly mixed with the antibiotic residue and to speed up the reaction rate.

In the embodiment of the present invention, the antibiotic residue is cephalosporin fermentation residue containing residual antibiotic produced during the antibiotic production process, and the antibiotic is cephalosporin C.

In the embodiment of the present invention, the residual cephalosporin C content in the cephalosporin fermentation residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation residue is 85%-95%.

In the embodiment of the present invention, the dosage of the calcium peroxide is 0.04mM-0.1mM.

Preferably, considering the removal effect and cost, the dosage of calcium peroxide is 0.06mM.

S202, sending the mixture to an irradiation chamber of an electron accelerator, and irradiating the mixture with an electron beam.

In the embodiment of the present invention, the mixture can be placed in the electron accelerator's under-beam transport system and transported to the electron accelerator's irradiation chamber by a conveyor belt for irradiation.

In the embodiment of the present invention, the radiation absorbed dose of the electron beam is 40kGy-75kGy.

Specifically, in the embodiment of the present invention, different radiation absorbed doses can be obtained by controlling the beam intensity and transmission speed.

Preferably, the radiation absorbed dose of the electron beam is 50kGy.

In the embodiment of the present invention, under the synergistic interaction between electron beam irradiation and calcium peroxide, the antibiotics in the antibiotic residues can be completely degraded, and the concentration of antibiotics can be reduced to undetectable by liquid chromatography. In the method provided by the embodiment of the present invention, electron beam irradiation is carried out at normal temperature, which is easy to realize large-scale industrial application.

Based on the above-mentioned inventive concept, the second aspect of the present invention proposes a system for treating antibiotic scum, which is used to implement the method for treating antibiotic slag described in any one of the first aspects of the embodiments of the present invention. Below in conjunction with accompanying drawing 3, another antibiotic slag processing system proposed by the present invention will be described. The system includes:

The reactor is used to hold the antibiotic residue for processing the antibiotic residue;

Calcium peroxide dosing device, used to add calcium peroxide to the reactor;

A stirring device (not shown in the figure), used to mix the antibiotic residue and the calcium peroxide to obtain a mixture;

An electron accelerator for generating an electron beam to irradiate the mixture to degrade the antibiotic in the antibiotic residue;

Wherein, the calcium peroxide is dissolved in the antibiotic slag with high water content to generate calcium ions, and under the acidic condition of the antibiotic slag, the calcium ions replace the hydrogen ions of the acidic protein to form insoluble protein-calcium precipitates, coagulate the protein, eliminate the competition effect of the protein on the hydroxyl radicals produced by electron beam irradiation, increase the number of hydroxyl radicals reacting with the antibiotics in the treatment system, and strengthen the electron beam irradiation to degrade the antibiotics in the antibiotic slag.

In the embodiment of the present invention, the antibiotic residue is cephalosporin fermentation residue containing residual antibiotics produced in the antibiotic production process, the antibiotic is cephalosporin C, the residual cephalosporin C content in the cephalosporin fermentation residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation residue is 85%-95%.

In the embodiment of the present invention, the dosage of the calcium peroxide is 0.04mM-0.1mM.

In the embodiment of the present invention, the radiation absorbed dose of the electron beam is 40kGy-75kGy.

In order to enable those skilled in the art to better understand the present invention, the method for treating antibiotic scum provided by the present invention will be described below through a number of specific examples.

Example 1

The cephalosporin fermentation residue is taken from an antibiotic production enterprise in the west of my country. Its water content is 91%, the C/N ratio is 4.9, the pH value is 4.0, the volatile suspended solids (VSS)/total suspended solids (TSS) ratio is 92%, and the concentration of residual CPC is 290 ± 12mg/kg. Calcium peroxide was of analytical grade commercially available. Hydrogen peroxide was commercially available of analytical grade.

Take about 50g of the cephalosporin fermentation residue mixture, add calcium peroxide 0.01mM, 0.02mM, 0.04mM, 0.06mM respectively, stir evenly, put it into a sample bag, and send it to the irradiation room of the electron accelerator by a conveyor belt for irradiation. The bacteria residue samples without calcium peroxide were irradiated at the same time for comparison. At the same time, in order to compare the advantages of calcium peroxide due to the presence of calcium ions compared with hydrogen peroxide irradiation enhancement, about 50 g of cephalosporin fermented slag mixture was taken, and hydrogen peroxide 0.02 mM and 0.04 mM were added respectively, stirred evenly, put into a sample bag, and sent to the irradiation room of the electron accelerator by a conveyor belt for irradiation at the same time. The irradiation removal effect of CPC under the same dosage of calcium peroxide and hydrogen peroxide was compared.

Different absorbed radiation doses of 30kGy, 40kGy, 50kGy, and 75kGy are obtained by controlling the beam intensity and transmission speed. The concentration of CPC in the bacterial residue before and after irradiation was detected.

The residual CPC in the bacterial residue was first extracted with phosphate buffered saline (PBS), and then detected by high performance liquid chromatography.

Among them, the CPC extraction method is as follows: take about 5 mg of bacterial residue and put it in a 50 mL polypropylene centrifuge tube, add 20 mL of 0.1 mol/LPBS buffer solution (pH 5.0), vortex for 1 min, and ultrasonically assist extraction for 30 min. Centrifuge at 6000rpm for 10min, take the supernatant, and filter it with a 0.22μm filter membrane into a sample injection vial for later use.

Wherein, the liquid chromatograph used is a high-performance liquid chromatograph (Agilent 1200) from Agilent Corporation of the United States, the chromatographic column is an XDB-C18 reverse-phase column, and the column temperature is 30°C. The detector is an ultraviolet detector, and the detection wavelength is 260nm; the mobile phase is 0.1% formic acid aqueous solution and acetonitrile, and the mixing ratio is 90:10.

The concentration of CPC detected in the bacterial residue is listed in Table 1 under the conditions of different absorbed radiation doses, calcium peroxide and hydrogen peroxide dosages. It can be seen that with electron beam irradiation alone, the absorbed dose increases from 30kGy to 40kGy, and the removal efficiency of CPC increases significantly from 76.7% to 92.0%. If the dose is continued to increase to 50kGy and 75kGy, the concentration of CPC drops to 12.5mg/kg and 8.5mg/kg, and the removal rate increases slightly, to 95.7% and 97.1%. Calcium peroxide itself has a weak ability to oxidize and degrade CPC in bacterial residues. When its dosage is 0.01mM-0.06mM, the removal rate of CPC is only 1.6%-10.4%.

Calcium peroxide can significantly promote the degradation efficiency of CPC in fungal residue by electron beam irradiation. Under the same absorbed radiation dose, the removal rate of CPC increased with the increase of calcium peroxide dosage. When the absorbed radiation dose was 40kGy, and the dosage of calcium peroxide increased from 0.01mM, 0.02mM, 0.04mM to 0.06mM, the removal rate of CPC increased from 97.0%, 98.7%, 99.6% to 100%. When the absorbed radiation dose is 50kGy, and the dosage of calcium peroxide increases from 0.01mM, 0.02mM to 0.04mM, the removal rate of CPC increases from 99.0%, 99.6% to 100%. When the absorbed dose is 40kGy, the dosage of calcium peroxide is 0.06mM and the absorbed dosage is 50kGy, and the dosage of calcium peroxide is 0.04 and 0.06, the concentration of CPC in the bacterial residue can be reduced to be undetectable by liquid chromatography.

The promoting effect of hydrogen peroxide on the degradation of CPC by irradiation was significantly lower than that of calcium peroxide, and the lower the concentration of CPC, the less obvious its enhancing effect was. When the dosage of hydrogen peroxide is 0.02mM and 0.04mM, and the absorbed radiation dose is 75kGy, the residual concentration of CPC in the fungus residue is 8.0mg/kg and 7.5mg/kg, which is basically close to the residual concentration of CPC of 8.5mg/kg when irradiated alone. The combination of electron beam irradiation and hydrogen peroxide could not reduce the antibiotic CPC in cephalosporin fermentation residue to undetectable by liquid chromatography.

The CPC content (mg/kg, ND represents not detected) in the antibiotic bacterium slag after table 1 embodiment 1 handles under different experimental conditions

Example 2

The cephalosporin fermentation residue is taken from an antibiotic production enterprise in the west of my country. Its water content is 89%, the C/N ratio is 4.5, the pH value is 3.8, the volatile suspended solids (VSS)/total suspended solids (TSS) ratio is 90%, and the concentration of residual CPC is 917±25mg/kg. Calcium peroxide was of analytical grade commercially available. Hydrogen peroxide was commercially available of analytical grade.

Take about 50g of the bacterial residue mixture, add calcium peroxide 0.02mM, 0.04mM, 0.06mM, 0.1mM respectively, and add hydrogen peroxide 0.04mM, 0.1mM respectively, stir evenly, put it into a sample bag, and send it to the irradiation room of the electron accelerator by a conveyor belt for irradiation. Separate fungal residue samples were irradiated at the same time for comparison. Different absorbed radiation doses of 30kGy, 40kGy, 50kGy, and 75kGy are obtained by controlling the beam intensity and transmission speed. The concentration of CPC in the bacterial residue before and after irradiation was detected.

The residual CPC in the bacterial residue was first extracted with PBS buffer solution, and then detected by liquid chromatography. The extraction and detection method of CPC are the same as in Example 1.

The CPC concentrations detected in cephalosporin residues under different absorbed radiation doses and calcium peroxide and hydrogen peroxide dosages are listed in Table 2. It can be seen that with electron beam irradiation alone, the degradation efficiency of CPC increases sharply at first and then tends to be flat with the increase of radiation absorbed dose. When the absorbed dose was 30kGy, 40kGy, 50kGy and 75kGy, the removal rate of CPC was 81.8%, 93.5%, 97.7% and 98.5%. Calcium peroxide itself has a weak ability to oxidize and degrade CPC in bacterial residues. When its dosage is 0.2mM-0.1mM, the removal rate of CPC is 4.3%-10.5%.

As shown in Table 2, as the dosage of calcium peroxide increases, the degradation efficiency of CPC increases during electron beam irradiation. When the absorbed radiation dose is 50kGy, and the dosage of calcium peroxide increases from 0.02mM, 0.04mM to 0.06mM, the removal rate of CPC increases from 99.6%, 99.9% to 100%, and the concentration of CPC can be reduced to undetectable by liquid chromatography. When the dosage of calcium peroxide is 0.1mM, the CPC in cephalosporin fermentation residue can be reduced to undetectable by liquid chromatography when the absorbed dose is 40kGy.

The promoting effect of hydrogen peroxide on the degradation of CPC by irradiation was significantly lower than that of calcium peroxide, and the lower the concentration of CPC, the less obvious its enhancing effect was. When the dosage of hydrogen peroxide is 0.04mM and 0.1mM, and the absorbed dose of radiation is 75kGy, CPC can still be detected, and its residual concentration of 12.0mg/kg and 11.0mg/kg is basically close to the residual concentration of CPC of 13.6mg/kg when irradiated alone. The combination of electron beam irradiation and hydrogen peroxide could not reduce the antibiotic CPC in cephalosporin fermentation residue to undetectable by liquid chromatography.

CPC content (mg/kg, ND represents not detected) in the antibiotic bacterium slag after table 2 embodiment 2 handles under different experimental conditions

This embodiment is only a preferred specific implementation of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be covered within the scope of protection of the present invention. Therefore, the protection scope of the present invention should be determined by the protection scope of the claims.

Having described preferred embodiments of embodiments of the present invention, additional changes and modifications can be made to these embodiments by those skilled in the art once the basic inventive concept is appreciated. Therefore, the appended claims are intended to be interpreted to cover the preferred embodiment and all changes and modifications which fall within the scope of the embodiments of the present invention.

Finally, it should also be noted that in this document, relational terms such as first and second etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article or end-equipment comprising a set of elements includes not only those elements but also other elements not expressly listed or which are inherent to such a process, method, article or end-equipment. Without further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article or terminal device comprising said element.

The method, device, server and storage medium of an antibiotic bacteria residue provided by the present invention have been introduced in detail above. In this paper, specific examples are used to illustrate the principle and implementation of the present invention. The description of the above examples is only used to help understand the method of the present invention and its core idea. At the same time, for those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation and scope of application. In summary, the content of this specification should not be understood as a limitation of the present invention.

Claims (7)

1. A method for treating antibiotic residues, the method comprising:

mixing the antibiotic residues with calcium peroxide to obtain a mixture;

irradiating the mixture by using an electron beam to degrade antibiotics in the antibiotic residues;

under the acidic condition of the antibiotic bacterial residues, the calcium ions replace hydrogen ions of acidic proteins to form insoluble protein-calcium precipitates, so that proteins are coagulated, the competitive action of the proteins on hydroxyl free radicals generated by electron beam irradiation is eliminated, the number of hydroxyl free radicals reacting with antibiotics in a treatment system is increased, and the degradation of antibiotics in the antibiotic bacterial residues by electron beam irradiation is enhanced;

the antibiotic residues are cephalosporin fermentation residues containing residual antibiotics generated in the production process of the antibiotics, and the antibiotics are cephalosporin C;

the addition amount of the calcium peroxide is 0.04 mM-0.1 mM.

2. The method for treating antibiotic residues according to claim 1, wherein the mixing of the antibiotic residues with calcium peroxide to obtain a mixture comprises:

adding calcium peroxide into the antibiotic residues, and uniformly mixing the antibiotic residues and the calcium peroxide to obtain a mixture;

irradiating the mixture with an electron beam, comprising:

the mixture is sent to an irradiation chamber of an electron accelerator, and is irradiated by an electron beam.

3. The antibiotic residue treatment method according to claim 1, wherein the content of residual cephalosporin C in the cephalosporin fermentation residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation residue is 85% -95%.

4. The antibiotic slag treatment method according to claim 1, wherein the irradiation absorbed dose of the electron beam is 40kGy to 75kGy.

5. An antibiotic slag treatment system for implementing the antibiotic slag treatment method of any one of claims 1-4, the system comprising:

the reactor is used for containing antibiotic residues so as to treat the antibiotic residues; the antibiotic residues are cephalosporin fermentation residues containing residual antibiotics generated in the production process of the antibiotics, and the antibiotics are cephalosporin C;

the calcium peroxide adding device is used for adding calcium peroxide into the reactor; the adding amount of the calcium peroxide is 0.04 mM-0.1 mM;

the stirring device is used for uniformly mixing the antibiotic residues with the calcium peroxide to obtain a mixture;

an electron accelerator for generating electron beams to irradiate the mixture so as to degrade antibiotics in the antibiotic residues;

under the acidic condition of the antibiotic bacterial residues, the calcium ions replace hydrogen ions of acidic proteins to form insoluble protein-calcium precipitates, so that proteins are coagulated, the competitive action of the proteins on hydroxyl free radicals generated by electron beam irradiation is eliminated, the number of hydroxyl free radicals reacting with antibiotics in a treatment system is increased, and the degradation of antibiotics in the antibiotic bacterial residues by electron beam irradiation is enhanced.

6. The antibiotic dregs treatment system according to claim 5, wherein the content of residual cephalosporin C in the cephalosporin fermentation dregs is 200-1000 mg/kg, and the water content of the cephalosporin fermentation dregs is 85% -95%.

7. The antibiotic slag treatment system of claim 5, wherein the radiation absorbed dose of the electron beam is between 40kGy and 75kGy.