CN114949720A - A kind of antibiotic bacteria residue treatment method and system - Google Patents

Abstract

The embodiment of the present invention provides a method and system for antibiotic slag. In the embodiment of the present invention, calcium peroxide is dissolved in the antibiotic slag with a high water content, and the generated calcium ions are in a strong acidic condition of the antibiotic slag. , can replace the hydrogen ions of acidic proteins, form insoluble protein-calcium precipitation, coagulate the protein, and then eliminate its competition with antibiotics to generate hydroxyl radicals from irradiation, so that the number of hydroxyl radicals reacting with antibiotics in the irradiation system is reduced. Significant increase, and then completely eliminate the antibiotic contamination in the antibiotic residue. In the embodiment of the present invention, under the synergistic interaction between electron beam irradiation and calcium peroxide, the antibiotics in the antibiotic slag can be completely degraded, so that the antibiotic concentration can be reduced to a level that cannot be detected by liquid chromatography, that is, the antibiotic removal rate can be up to 100%. In the method provided by the embodiment of the present invention, the electron beam irradiation is performed at normal temperature, which is easy to realize large-scale industrial application.

Description

A kind of antibiotic bacteria residue treatment method and system

technical field

Embodiments of the present invention relate to the field of solid waste treatment, and in particular, to a method and system for treating bacterial residues of antibiotics.

Background technique

Cephalosporin antibiotics are currently one of the most widely used broad-spectrum antibiotics, and cephalosporin C (CPC) is the main API of cephalosporin antibiotics. CPC is produced by aerobic fermentation using Cephalosporium acremonium as the fermenting strain and using corn steep liquor, peanut flour, dextrin, methionine, soybean oil, inorganic salts, etc. as the medium. After the fermentation process is completed, sulfuric acid is added to the fermentation broth for acidification to precipitate mycelium and protein, the supernatant is filtered through a ceramic membrane to remove macromolecular protein substances, and then the final raw material drug product is obtained through resin adsorption purification, concentration and other processes. The sulfuric acid-acidified precipitate and the concentrated solution separated by the ceramic membrane are the antibiotic slag waste, and its main components are residual mycelium, culture medium and antibiotics.

Antibiotic slag is rich in nutrients, rich in polysaccharide, protein, various amino acids and trace elements, etc., and the protein content can reach more than 30%. Residual antibiotics are the source of pollution in antibiotic residues. If they can be removed from antibiotic residues, antibiotic residues are expected to be removed from hazardous wastes. The harmless antibiotic residues can be made into fertilizers and turned into resources for reuse. , and then solve the problem of treatment and disposal of antibiotic residues.

Antibiotic bacterial residue is a viscous solid-liquid mixture, and it is difficult to penetrate into the internal reaction of bacterial residue by common treatment methods such as ultraviolet and photocatalysis, and the removal rate of antibiotics is not high.

Therefore, there is an urgent need for a high-removal antibiotic bacterial residue treatment method.

SUMMARY OF THE INVENTION

The embodiments of the present invention provide a method and system for treating antibiotic slag, so as to degrade the antibiotic in the antibiotic slag, so that the concentration of the antibiotic in the antibiotic slag is reduced to a level that cannot be detected by liquid chromatography.

A first aspect of the embodiments of the present invention provides a method for antibiotic slag, the method comprising:

The antibiotic bacterial residue is mixed with calcium peroxide to obtain a mixture;

The mixture is irradiated with an electron beam to degrade the antibiotics in the antibiotic slag;

Wherein, the calcium peroxide dissolves to produce calcium ions, and under the acidic conditions of the antibiotic slag, the calcium ions replace the hydrogen ions of the acidic protein to form insoluble protein-calcium precipitation, so that the protein coagulates and eliminates the electron pair of the protein. The competition of hydroxyl radicals generated by beam irradiation increases the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthens the degradation of antibiotics in antibiotic slag by electron beam irradiation.

Optionally, the antibiotic bacterial residue is mixed with calcium peroxide to obtain a mixture, including:

Add calcium peroxide to the antibiotic bacterial residue, and mix the antibiotic bacterial residue with the calcium peroxide to obtain a mixture;

The mixture is irradiated with an electron beam, including:

The mixture is sent to an irradiation chamber of an electron accelerator, and the mixture is irradiated with an electron beam.

Optionally, the antibiotic residue is a cephalosporin fermentation residue containing residual antibiotics produced in the antibiotic production process, and the antibiotic is cephalosporin C.

Optionally, the residual cephalosporin C content in the cephalosporin fermentation bacteria residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation bacteria residue is 85%-95%.

Optionally, the radiation absorbed dose of the electron beam is 40kGy˜75kGy.

Optionally, the dosage of the calcium peroxide is 0.04 mM to 0.1 mM.

A second aspect of the embodiment of the present invention provides an antibiotic bacterial residue system, the system is used to realize the antibiotic bacterial residue treatment method according to any one of the above-mentioned first aspect, and the system includes:

a reactor for holding antibiotic bacterial residues, to process the antibiotic bacterial residues;

A calcium peroxide dosing device for adding calcium peroxide to the reactor;

a stirring device for mixing the antibiotic bacterial residue with the calcium peroxide to obtain a mixture;

an electron accelerator for generating electron beams to irradiate the mixture to degrade the antibiotics in the antibiotic slag;

Wherein, the calcium peroxide dissolves to produce calcium ions, and under the acidic conditions of the antibiotic slag, the calcium ions replace the hydrogen ions of the acidic protein to form insoluble protein-calcium precipitation, so that the protein coagulates and eliminates the electron pair of the protein. The competition of hydroxyl radicals generated by beam irradiation increases the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthens the degradation of antibiotics in antibiotic slag by electron beam irradiation.

Optionally, the antibiotic slag is a cephalosporin fermentation slag containing residual antibiotics produced in the antibiotic production process, the antibiotic is cephalosporin C, and the residual cephalosporin C content in the cephalosporin fermentation slag is 200. ~1000mg/kg, the moisture content of the cephalosporin fermentation bacteria residue is 85%-95%.

Optionally, the radiation absorbed dose of the electron beam is 40kGy˜75kGy.

Optionally, the dosage of the calcium peroxide is 0.04 mM to 0.1 mM.

In the antibiotic bacterial residue method provided by the embodiment of the present invention, the radiation effect of electron beams and the acidic environment of the antibiotic bacterial residue (the pH value is usually about 4.0) are conducive to the in-situ decomposition of calcium peroxide to generate hydrogen peroxide. The reaction of the generated e _aq - and ·H promotes the production of ·OH; at the same time, the calcium ions generated by the dissolution of calcium peroxide can replace the hydrogen ions of acidic proteins under the strong acidic conditions of the antibiotic slag to form insoluble protein-calcium Precipitation makes the protein coagulate, and then eliminates its competitive effect with antibiotics to generate hydroxyl radicals on irradiation, significantly increases the number of hydroxyl radicals reacting with antibiotics in the irradiation system, and completely eliminates antibiotic pollution in antibiotic slag.

In the embodiment of the present invention, under the synergistic interaction between electron beam irradiation and calcium peroxide, the antibiotics in the antibiotic slag can be completely degraded, so that the antibiotic concentration can be reduced to a level that cannot be detected by liquid chromatography, that is, the antibiotic removal rate can be up to 100%. In the method provided by the embodiment of the present invention, the electron beam irradiation is performed at normal temperature, which is easy to realize large-scale industrial application. It can be seen that the method provided by the implementation of the present invention is efficient, convenient and widely applicable, can be applied to the treatment of antibiotic bacterial residues, and has broad application prospects in the field of hazardous solid waste treatment.

Description of drawings

In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the following briefly introduces the drawings that are used in the description of the embodiments of the present invention. Obviously, the drawings in the following description are only some embodiments of the present invention. , for those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative labor.

Fig. 1 is the flow chart of a kind of antibiotic bacterial residue method of the embodiment of the present invention;

Fig. 2 is the flow chart of another kind of antibiotic bacterial residue method of the embodiment of the present invention;

3 is a schematic diagram of an antibiotic bacterial residue system according to an embodiment of the present invention.

Detailed ways

In order to make the above objects, features and advantages of the present invention more clearly understood, the present invention will be described in further detail below with reference to the accompanying drawings and specific embodiments.

Electron beam irradiation technology uses electron beams generated by electron accelerators to treat pollutants. An electron beam is a dense stream of high-speed electrons with extremely high energy density. The high-energy electron beam can penetrate deep into the slag and directly destroy the molecular structure of the antibiotic through the Compton effect; at the same time, the electron beam can stimulate the ionization of water molecules to generate active particles such as OH, e _aq -, and H (as shown in formula 1). shown, the values in parentheses are the radiation chemical yields of each active particle), antibiotics can be degraded by oxidation-reduction reaction with these active particles.

During the treatment of antibiotic residues by electron beam irradiation, when the absorbed dose is 40kGy, the removal rate of antibiotics can reach more than 90%. But continuing to increase the dosage, the improvement of the antibiotic removal rate is not large, and the ideal removal rate cannot be achieved.

In the related art, the commonly used method is to use an oxidant to strengthen the electron beam irradiation to degrade the antibiotics in the bacterial residue, so as to generate more strongly oxidizing OH, promote the oxidation-reduction reaction, and then promote the degradation of the antibiotics. This method still cannot achieve the effect of reducing the antibiotic concentration to undetectable by liquid chromatography, and thus cannot achieve the ideal removal rate.

Therefore, the inventors explored the treatment method of antibiotic slag, and found that the proteins, polysaccharides and other substances present in the antibiotic slag solution compete with the antibiotics for free radicals generated by irradiation, thereby limiting the further degradation of the antibiotics. The lower the concentration of antibiotics, the stronger the competition between these substances and the greater the impact on the degradation of antibiotics. Among them, the irradiation competition of proteins is the strongest. In order to completely eliminate antibiotic pollution, it is necessary to inhibit the irradiation competition of proteins.

Based on the above-mentioned exploration and discovery, the inventive concept of the present application is proposed: strengthen the electron beam irradiation with calcium peroxide to degrade the antibiotics in the bacterial residue, wherein, the calcium peroxide dissolves in the antibiotic bacterial residue with higher water content to produce calcium ions, Under the acidic conditions of antibiotic slag, calcium ions replace the hydrogen ions of acidic proteins, forming insoluble protein-calcium precipitates, coagulating the proteins, eliminating the competitive effect of proteins on hydroxyl radicals generated by electron beam irradiation, and making the treatment system The number of hydroxyl radicals reacting with antibiotics increased, and the electron beam irradiation was enhanced to degrade the antibiotics in the antibiotic slag.

Based on the above-mentioned inventive concept, the first aspect of the present invention proposes a method for treating bacterial residues of antibiotics. The method for treating bacterial residues of antibiotics proposed by the present invention will be described below in conjunction with accompanying drawing 1, and the method comprises the following steps:

S101, mixing antibiotic bacterial residue and calcium peroxide to obtain a mixture.

In the embodiment of the present invention, any feasible method in the related art may be used to mix the antibiotic bacterial residue and calcium peroxide, which is not specifically limited in the embodiment of the present invention.

S102, irradiating the mixture with electron beams to degrade the antibiotics in the antibiotic residues.

In the embodiment of the present invention, any feasible method in the related art may be used to irradiate the mixture with an electron beam, which is not specifically limited in the embodiment of the present invention.

In the embodiment of the present invention, calcium peroxide is dissolved in the antibiotic slag with high water content to generate calcium ions, and under the acidic conditions of the antibiotic slag, the calcium ions replace the hydrogen ions of the acidic protein to form insoluble Protein-calcium precipitation makes protein coagulate, eliminates the competitive effect of protein on hydroxyl radicals generated by electron beam irradiation, increases the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthens electron beam irradiation to degrade antibiotic bacteria residues. antibiotic.

In the embodiment of the present invention, the radiation effect of the electron beam and the acidic environment of the antibiotic slag make the calcium peroxide decompose in situ to generate hydrogen peroxide, and the reaction between the hydrogen peroxide and the e _aq - and ·H generated by the electron beam irradiation promotes the OH production can further enhance the degradation of antibiotics in antibiotic slag by electron beam irradiation by promoting oxidation-reduction reaction.

Based on the above-mentioned inventive concept, the present invention also proposes another method for treating bacterial residues of antibiotics. Below in conjunction with accompanying drawing 2, another method for treating bacterial residues of antibiotics proposed by the present invention will be described, and the method comprises the following steps:

S201, adding calcium peroxide to the antibiotic bacteria residue, and mixing the antibiotic bacteria residue with the calcium peroxide to obtain a mixture.

In the embodiment of the present invention, the calcium peroxide can be selected as a powdered solid, so as to be evenly mixed with the antibiotic slag and to speed up the reaction rate.

In the embodiment of the present invention, the antibiotic slag is cephalosporin fermentation slag containing residual antibiotics produced in the antibiotic production process, and the antibiotic is cephalosporin C.

In the embodiment of the present invention, the residual cephalosporin C content in the cephalosporin fermentation residue is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation residue is 85%-95%.

In the embodiment of the present invention, the dosage of the calcium peroxide is 0.04 mM to 0.1 mM.

Preferably, considering the removal effect and cost, the dosage of the calcium peroxide is 0.06mM.

S202, the mixture is sent to an irradiation chamber of an electron accelerator, and the mixture is irradiated with an electron beam.

In the embodiment of the present invention, the mixture can be placed in the under-beam transmission system of the electron accelerator and sent to the irradiation chamber of the electron accelerator by means of a conveyor belt for irradiation.

In the embodiment of the present invention, the radiation absorption dose of the electron beam is 40kGy˜75kGy.

Specifically, in the embodiment of the present invention, different absorbed doses of radiation can be obtained by controlling the beam intensity and transmission speed.

Preferably, the radiation absorbed dose of the electron beam is 50 kGy.

In the embodiment of the present invention, under the synergistic interaction between electron beam irradiation and calcium peroxide, the antibiotics in the antibiotic slag can be completely degraded, and the antibiotic concentration can be reduced to be undetectable by liquid chromatography. In the method provided by the embodiment of the present invention, the electron beam irradiation is performed at normal temperature, which is easy to realize large-scale industrial application.

Based on the above inventive concept, the second aspect of the present invention proposes an antibiotic bacterial residue treatment system, which is used to realize the antibiotic bacterial residue treatment method described in any one of the first aspect of the embodiments of the present invention. Another proposed antibiotic bacteria residue treatment system is described, and the system includes:

a reactor for holding antibiotic bacterial residues, to process the antibiotic bacterial residues;

A calcium peroxide dosing device for adding calcium peroxide to the reactor;

a stirring device (not shown in the figure), for mixing the antibiotic bacterial residue with the calcium peroxide to obtain a mixture;

an electron accelerator for generating electron beams to irradiate the mixture to degrade the antibiotics in the antibiotic slag;

Wherein, the calcium peroxide is dissolved in the antibiotic slag with higher water content to generate calcium ions, and under the acidic conditions of the antibiotic slag, the calcium ions replace the hydrogen ions of the acidic protein to form insoluble protein- Calcium precipitation makes protein coagulate, eliminates the competitive effect of protein on hydroxyl radicals generated by electron beam irradiation, increases the number of hydroxyl radicals reacting with antibiotics in the treatment system, and strengthens electron beam irradiation to degrade antibiotics in antibiotic slag.

In the embodiment of the present invention, the antibiotic slag is cephalosporin fermentation slag containing residual antibiotics produced in the antibiotic production process, the antibiotic is cephalosporin C, and the residual cephalosporin C content in the cephalosporin fermentation slag It is 200-1000 mg/kg, and the moisture content of the cephalosporin fermentation bacteria residue is 85%-95%.

In the embodiment of the present invention, the dosage of the calcium peroxide is 0.04 mM to 0.1 mM.

In the embodiment of the present invention, the radiation absorption dose of the electron beam is 40kGy˜75kGy.

In order for those skilled in the art to better understand the present invention, the method for treating antibiotic bacterial residues provided by the present invention will be described below through a plurality of specific embodiments.

Example 1

Cephalosporin fermentation residue was taken from an antibiotic production enterprise in western my country. Its moisture content was 91%, the C/N ratio was 4.9, the pH value was 4.0, and the volatile suspended solids (VSS)/total suspended solids (TSS) ratio was 92%. , the concentration of residual CPC was 290±12mg/kg. Calcium peroxide was commercially available of analytical grade. Hydrogen peroxide was of commercially available analytical grade.

Take about 50g of cephalosporin fermentation bacteria residue mixture, add calcium peroxide 0.01mM, 0.02mM, 0.04mM, 0.06mM respectively, stir evenly, put it into a sample bag, and send it to the irradiation room of the electron accelerator with a conveyor belt for irradiation. The bacterial residue samples without calcium peroxide were irradiated at the same time for comparison. At the same time, in order to compare the advantages of calcium peroxide due to the presence of calcium ions compared to the strengthening effect of hydrogen peroxide irradiation, about 50 g of cephalosporin fermentation bacteria residue mixture was taken, and 0.02 mM and 0.04 mM hydrogen peroxide were added respectively, stirred evenly, and then placed into the sample bag and transported to the irradiation chamber of the electron accelerator with a conveyor belt for simultaneous irradiation. The irradiation removal effects of CPC under the same dosage of calcium peroxide and hydrogen peroxide were compared.

Different radiation absorbed doses of 30kGy, 40kGy, 50kGy and 75kGy were obtained by controlling the beam intensity and transmission speed. The concentration of CPC in the bacterial residue before and after irradiation was detected.

The residual CPC in the bacterial residue was first extracted with phosphate buffered solution (PBS), and then detected by high performance liquid chromatography.

Among them, the CPC extraction method was as follows: about 5 mg of bacterial residue was placed in a 50 mL polypropylene centrifuge tube, 20 mL of 0.1 mol/L PBS buffer (pH 5.0) was added, vortexed for 1 min, and ultrasonic-assisted extraction was performed for 30 min. Centrifuge at 6000 rpm for 10 min, take the supernatant and filter it with a 0.22 μm filter into a sample injection vial for later use.

Wherein, the liquid chromatograph used was a high performance liquid chromatograph (Agilent1200) from Agilent, USA, the chromatographic column was an XDB-C18 reversed-phase column, and the column temperature was 30°C. The detector is an ultraviolet detector, and the detection wavelength is 260 nm; the mobile phase is 0.1% formic acid aqueous solution and acetonitrile, and the mixing ratio is 90:10.

The CPC concentrations detected in the bacterial residue under different irradiation absorbed doses and dosages of calcium peroxide and hydrogen peroxide are listed in Table 1. It can be seen that with electron beam irradiation alone, the absorbed dose increased from 30kGy to 40kGy, and the removal efficiency of CPC increased significantly from 76.7% to 92.0%; continuing to increase the dose to 50kGy and 75kGy, the concentration of CPC decreased to 12.5mg/kg and 8.5mg/kg, the removal rate was not much improved, 95.7% and 97.1%. The oxidative degradation ability of calcium peroxide itself to CPC in bacterial residue is weak, and the removal rate of CPC is only 1.6%-10.4% when its dosage is 0.01mM-0.06mM.

Calcium peroxide can significantly promote the degradation efficiency of CPC in bacterial residues by electron beam irradiation. Under the same radiation absorbed dose, the removal rate of CPC increased with the increase of calcium peroxide dosage. When the absorbed dose of irradiation was 40kGy and the dosage of calcium peroxide increased from 0.01mM, 0.02mM, 0.04mM to 0.06mM, the CPC removal rate increased from 97.0%, 98.7%, 99.6% to 100%. When the absorbed dose of irradiation was 50kGy and the dosage of calcium peroxide increased from 0.01mM and 0.02mM to 0.04mM, the CPC removal rate increased from 99.0% and 99.6% to 100%. When the absorbed dose was 40kGy, the dosage of calcium peroxide was 0.06mM, and the absorbed dose was 50kGy, the dosage of calcium peroxide was 0.04 and 0.06, the CPC concentration in the bacterial residue could not be detected by liquid chromatography.

The promotion effect of hydrogen peroxide on irradiation degradation of CPC was significantly lower than that of calcium peroxide, and the lower the concentration of CPC, the less obvious the promotion effect was. When the dosage of hydrogen peroxide was 0.02 mM and 0.04 mM, and the absorbed dose of irradiation was 75 kGy, the residual concentration of CPC in the bacterial residue was 8.0 mg/kg and 7.5 mg/kg, which was basically close to the residual concentration of CPC when irradiated alone. 8.5mg/kg. The combination of electron beam irradiation and hydrogen peroxide could not reduce the antibiotic CPC in cephalosporin fermentation residue to be undetectable by liquid chromatography.

Table 1 Example 1 CPC content (mg/kg, ND means not detected) in the antibiotic slag after treatment under different experimental conditions

Example 2

Cephalosporin fermentation residue was taken from an antibiotic production enterprise in western my country. Its moisture content was 89%, the C/N ratio was 4.5, the pH value was 3.8, and the volatile suspended solids (VSS)/total suspended solids (TSS) ratio was 90%. , the concentration of residual CPC was 917±25mg/kg. Calcium peroxide was commercially available of analytical grade. Hydrogen peroxide was of commercially available analytical grade.

Take about 50g of bacterial residue mixture, add calcium peroxide 0.02mM, 0.04mM, 0.06mM, 0.1mM respectively, and add hydrogen peroxide 0.04mM, 0.1mM respectively, stir evenly, put it into the sample bag, and send it to the Irradiation is carried out in the irradiation chamber of the electron accelerator. Individual bacterial residue samples were irradiated at the same time for comparison. Different radiation absorbed doses of 30kGy, 40kGy, 50kGy and 75kGy were obtained by controlling the beam intensity and transmission speed. The concentration of CPC in the bacterial residue before and after irradiation was detected.

The residual CPC in the bacterial residue was first extracted with PBS buffer solution, and then detected by liquid chromatography. The extraction and detection methods of CPC are the same as those in Example 1.

The CPC concentrations detected in the cephalosporin residues under different irradiation absorbed doses and dosages of calcium peroxide and hydrogen peroxide are listed in Table 2. It can be seen that with electron beam irradiation alone, the degradation efficiency of CPC increases sharply at first and then tends to level off with the increase of the absorbed dose of irradiation. When the absorbed doses were 30kGy, 40kGy, 50kGy and 75kGy, the CPC removal rates were 81.8%, 93.5%, 97.7% and 98.5%. The oxidative degradation ability of calcium peroxide itself to CPC in bacterial residue is weak, and the removal rate of CPC is 4.3%-10.5% when its dosage is 0.2mM-0.1mM.

As shown in Table 2, the degradation efficiency of CPC during electron beam irradiation increased with the increase of calcium peroxide dosage. When the absorbed dose of irradiation was 50kGy and the dosage of calcium peroxide increased from 0.02mM and 0.04mM to 0.06mM, the CPC removal rate increased from 99.6% and 99.9% to 100%, and the CPC concentration could be reduced to a level that could not be detected by liquid chromatography. out. When the dosage of calcium peroxide is 0.1 mM, and the absorbed dose is 40 kGy, the CPC in the cephalosporin fermentation residue can be reduced to be undetectable by liquid chromatography.

The promotion effect of hydrogen peroxide on irradiation degradation of CPC was significantly lower than that of calcium peroxide, and the lower the concentration of CPC, the less obvious the promotion effect was. When the dosage of hydrogen peroxide is 0.04mM and 0.1mM, and the absorbed dose of irradiation is 75kGy, CPC can still be detected, and its residual concentration of 12.0mg/kg and 11.0mg/kg is basically close to the CPC residual concentration of 13.6 when irradiated alone mg/kg. The combination of electron beam irradiation and hydrogen peroxide could not reduce the antibiotic CPC in cephalosporin fermentation residue to be undetectable by liquid chromatography.

The CPC content (mg/kg, ND means not detected) in the antibiotic slag after treatment under the different experimental conditions of table 2 embodiment 2

This embodiment is only a preferred embodiment of the present invention, but the protection scope of the present invention is not limited to this. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention. , all should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.

Although preferred embodiments of the embodiments of the present invention have been described, additional changes and modifications to these embodiments may be made by those skilled in the art once the basic inventive concepts are known. Therefore, the appended claims are intended to be construed to include the preferred embodiments as well as all changes and modifications that fall within the scope of the embodiments of the present invention.

Finally, it should also be noted that in this document, relational terms such as first and second are used only to distinguish one entity or operation from another, and do not necessarily require or imply these entities or there is any such actual relationship or sequence between operations. Moreover, the terms "comprising", "comprising" or any other variation thereof are intended to encompass non-exclusive inclusion, such that a process, method, article or terminal device comprising a list of elements includes not only those elements, but also a non-exclusive list of elements. other elements, or also include elements inherent to such a process, method, article or terminal equipment. Without further limitation, an element defined by the phrase "comprises a..." does not preclude the presence of additional identical elements in the process, method, article or terminal device comprising said element.

The method, device, server and storage medium for antibiotic bacteria residues provided by the present invention have been described above in detail. In this paper, specific examples are used to illustrate the principles and implementations of the present invention. In order to help understand the method of the present invention and its core idea; at the same time, for those skilled in the art, according to the idea of the present invention, there will be changes in the specific implementation and application scope. In summary, this specification The contents should not be construed as limiting the present invention.

Claims (10)

1. An antibiotic fungi residue treatment method is characterized by comprising the following steps:

mixing antibiotic fungi residues with calcium peroxide to obtain a mixture;

irradiating the mixture by using an electron beam to degrade antibiotics in the antibiotic fungi residues;

the calcium peroxide is dissolved to generate calcium ions, the calcium ions replace hydrogen ions of acidic protein under the acidic condition of the antibiotic bacteria residues to form insoluble protein-calcium precipitate, the protein is coagulated, the competition effect of the protein on hydroxyl free radicals generated by electron beam irradiation is eliminated, the number of the hydroxyl free radicals reacted with the antibiotic in a treatment system is increased, and the antibiotic in the antibiotic bacteria residues is degraded by the electron beam irradiation.

2. The method of antibiotic pomace treatment according to claim 1, characterized in that said mixing of antibiotic pomace with calcium peroxide results in a mixture comprising:

adding calcium peroxide into the antibiotic fungi residues, and uniformly mixing the antibiotic fungi residues and the calcium peroxide to obtain a mixture;

irradiating the mixture with an electron beam comprising:

and sending the mixture to an irradiation chamber of an electron accelerator, and irradiating the mixture by using an electron beam.

3. The method for treating the antibiotic residues according to claim 1, wherein the antibiotic residues are cephalosporin fermentation residues containing residual antibiotics generated in the antibiotic production process, and the antibiotics are cephalosporin C.

4. The antibiotic bacteria residue treatment method as claimed in claim 3, wherein the content of residual cephalosporin C in the cephalosporin fermentation bacteria residue is 200-1000 mg/kg, and the water content of the cephalosporin fermentation bacteria residue is 85-95%.

5. The method for treating antibiotic fungi residues according to claim 1, wherein the radiation absorbed dose of the electron beam is 40-75 kGy.

6. The method of treating antibiotic residues according to claim 1, wherein the calcium peroxide is added in an amount of 0.04mM to 0.1 mM.

7. An antibiotic-bacteria-residue treatment system for implementing the antibiotic-bacteria-residue treatment method according to any one of claims 1 to 6, the system comprising:

the reactor is used for containing antibiotic fungi residues so as to treat the antibiotic fungi residues;

the calcium peroxide feeding device is used for feeding calcium peroxide into the reactor;

the stirring device is used for uniformly mixing the antibiotic fungi residues and the calcium peroxide to obtain a mixture;

the electron accelerator is used for generating electron beams to irradiate the mixture so as to degrade antibiotics in the antibiotic fungi residues;

the calcium peroxide is dissolved to generate calcium ions, the calcium ions replace hydrogen ions of acidic protein under the acidic condition of the antibiotic bacteria residues to form insoluble protein-calcium precipitate, the protein is coagulated, the competition effect of the protein on hydroxyl free radicals generated by electron beam irradiation is eliminated, the number of the hydroxyl free radicals reacted with the antibiotic in a treatment system is increased, and the antibiotic in the antibiotic bacteria residues is degraded by the electron beam irradiation.

8. The antibiotic fungi residue processing system of claim 7, wherein the antibiotic fungi residue is cephalosporin fermentation fungi residue containing residual antibiotic generated in the antibiotic production process, the antibiotic is cephalosporin C, the content of the residual cephalosporin C in the cephalosporin fermentation fungi residue is 200-1000 mg/kg, and the water content of the cephalosporin fermentation fungi residue is 85-95%.

9. The antibiotic mushroom dreg processing system according to claim 7, wherein the radiation absorbed dose of the electron beam is 40kGy to 75 kGy.

10. The antibiotic bagasse processing system according to claim 7, wherein the calcium peroxide is added in an amount of 0.04mM to 0.1 mM.

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