CN114886962A

CN114886962A - Medicine for oral bacteriostasis and preparation method thereof

Info

Publication number: CN114886962A
Application number: CN202210459923.8A
Authority: CN
Inventors: 张红燕
Original assignee: Shaanxi Huaqianman Biotechnology Co Ltd
Current assignee: Shaanxi Huaqianman Biotechnology Co Ltd
Priority date: 2022-04-24
Filing date: 2022-04-24
Publication date: 2022-08-12

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine for oral bacteriostasis and a preparation method thereof, wherein the medicine for oral bacteriostasis is obtained by mixing a bacteriostasis combined solution, water and medicines of all components, can effectively inhibit and kill bacteria in the oral environment, and simultaneously keeps longer retention time; and through the mixing of preparation facilities to the medicine component, can effectively improve mixing effect and efficiency, reach the purpose that each component evenly distributed and fuse.

Description

Medicine for oral bacteriostasis and preparation method thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a medicine for oral bacteriostasis and a preparation method thereof.

Background

Oral diseases are common diseases at present, and according to the third national oral health epidemiological survey, the prevalence rate of the oral diseases in China is up to more than 90%, and the oral diseases are as small as halitosis and cancer, so that the maintenance of the health of the oral environment is very important.

The oral diseases are caused by the body, and are often influenced by external harmful bacteria, so that the oral environment is damaged and influenced, and simultaneously, the excessive generation of harmful bacteria also easily causes complications such as hypertension, diabetes and the like, so that the inhibition and the killing of the bacteria in the oral environment are one of important measures for keeping the oral health environment, and the existing common oral bacteriostatic drugs are poor in the killing and the persistence of the bacteria, and are difficult to meet the requirement of oral bacteriostatic.

Disclosure of Invention

The purpose of the invention is: aims to provide a medicament for oral bacteriostasis and a preparation method thereof, which can more effectively inhibit and kill bacteria in the oral environment to meet the requirement of keeping healthy oral environment.

In order to achieve the technical purpose, the technical scheme adopted by the invention is as follows:

a medicine for oral cavity bacteriostasis is prepared from edible essence, active agent, algefacient, antiseptic, water and antibacterial composition liquid;

the components of the antibacterial combined solution comprise octenidine and a plant extracting solution, wherein the weight ratio of the octenidine to the plant extracting solution is 1: 10-30 parts of;

the plant extracting solution is prepared from the following components in parts by weight: 5-10: 1-5: 1-5 of radix angelicae, fructus forsythiae, pepper and rhizoma atractylodis;

the extraction steps of the plant extract are as follows: primarily extruding all plant raw materials to be extracted by a press machine, soaking in water for 20h-24h, heating and extracting for 4h-8h by using a 120-degree oil bath to obtain volatile oil, finally adding anhydrous ether, standing, filtering, and removing ether by an evaporator to obtain an extracting solution.

The active agent is glycerin fatty acid ester, the algefacient can be menthol or menthane carboxamide, the preservative is phenoxyethanol, and the water is mixed with 2-phenoxyethanol.

The components by weight percentage concentration are 0.1-1.5% of edible essence, 0.1-0.2% of active agent, 1-2% of freshener, 0.1-0.2% of preservative, 0.8-25% of bacteriostatic combined liquid and the balance of water.

A preparation method of a medicine for oral bacteriostasis comprises the following steps:

the method comprises the following steps: primarily mixing octenidine and plant extract to obtain a first mixed solution;

step two: adding edible essence, an active agent, a freshener and a preservative into water, and mixing to obtain a second mixed solution;

step three: and gradually adding the first mixed solution into the second mixed solution to obtain the oral bacteriostatic medicine.

A preparation device for oral cavity bacteriostatic drugs comprises a control panel and a stirring barrel, wherein the stirring barrel is provided with a liquid inlet and a liquid outlet, the upper end of the stirring barrel is provided with a motor, a main shaft in transmission connection with an output shaft of the motor is rotationally arranged in the stirring barrel, and a stirring mechanism matched with the main shaft is arranged in the stirring barrel;

the stirring mechanism consists of two pumping assemblies which are symmetrically distributed and connected with the main shaft and a pressure application assembly, the pressure application assembly comprises two arc-shaped convex plates and a blocking plate, the two arc-shaped convex plates are symmetrically arranged at the upper end of the stirring barrel and are not connected with each other, and the blocking plate is fixedly connected with the upper side of the main shaft;

pump suction subassembly includes long post, loose axle, restorer, two transfer lines and two piston bodies, long post middle part through the connecting plate with main shaft fixed connection, long post middle part longitudinal symmetry is opened there is the piston chamber, loose axle sliding seal locates long post and stretch into two the piston intracavity, loose axle one end slides and runs through the baffler, the restorer with state the loose axle and be connected and be located the baffler upside, two the piston body sliding seal respectively locates two the piston intracavity and all with the loose axle is connected, two the transfer line is respectively with two the piston chamber is connected and is matchd.

The restorer comprises a reset spring and a limiting sheet, the limiting sheet is fixedly arranged on the upper side of the movable shaft, and the reset spring is sleeved on the movable shaft and is located between the limiting sheet and the blocking plate.

The movable shaft sleeve is provided with a protection ring, and the protection ring is positioned between the blocking plate and the reset spring.

The long column is kept away from both ends mutually and all is equipped with and corresponds the side the first one-way feed liquor valve of piston chamber UNICOM, the transfer line includes catheter and branch liquid pipe, catheter and corresponding piston chamber UNICOM is equipped with one-way flowing back valve, divide the liquid pipe be the semicircle form and with catheter UNICOM, divide the liquid pipe evenly to be equipped with a plurality of leakage fluid ports, the drain pipe is evenly opened along its length direction has a plurality of by pass ports.

The middle part of the upper end of the stirring barrel is fixedly provided with an annular shell, the annular shell is connected with the main shaft in a rotating and sealing manner, the annular shell is communicated with a liquid inlet pipe, the middle part of the main shaft is provided with an infusion channel communicated with the annular shell, the connecting plate is provided with a by-pass channel communicated with the infusion channel, two ends of the long column are provided with by-pass pipes connected with the corresponding by-pass channels, and the by-pass pipes are provided with second one-way liquid inlet valves.

The medicine for oral bacteriostasis prepared by the components can effectively inhibit bacteria in the oral environment, does not damage the oral environment, and can keep longer retention time so as to inhibit the quantity of the bacteria in the oral environment; and cooperate above-mentioned preparation facilities, can effectively improve the mixed effect when mixing each component, reach the effect of each component evenly distributed.

Drawings

The invention is further illustrated by the non-limiting examples given in the figures.

Fig. 1 is a schematic structural diagram of an embodiment of a device for preparing a medicament for oral bacteriostasis according to the present invention.

Fig. 2 is a sectional view of the overall structure of the present invention.

Fig. 3 is an enlargement at a in fig. 2.

Fig. 4 is an enlargement at B in fig. 2.

Fig. 5 is a schematic view of the pumping assembly and pressure application assembly of the present invention.

FIG. 6 is a schematic diagram of the pumping assembly of the present invention.

The device comprises a stirring barrel 1, a liquid inlet 11, a liquid outlet 12, a motor 13, a main shaft 2, an arc-shaped convex plate 21, a blocking plate 22, a long column 3, a movable shaft 31, a liquid conveying pipe 32, a liquid guide pipe 321, a bypass port 3211, a one-way liquid outlet valve 3212, a liquid distributing pipe 322, a piston body 33, a piston cavity 34, a first one-way liquid inlet valve 35, a return spring 4, a limiting piece 41, a protection ring 42, an annular shell 5, a liquid inlet pipe 51, a liquid conveying channel 52, a bypass channel 53, a bypass pipe 54 and a second one-way liquid inlet valve 55.

Detailed Description

In order that those skilled in the art can better understand the present invention, the following technical solutions are further described with reference to the accompanying drawings and examples.

the antibacterial combined liquid comprises octenidine and plant extract, wherein the weight ratio of the octenidine to the plant extract is 1: 10-30 parts of;

the weight ratio of the plant extract is 15: 5-10: 1-5: 1-5 of radix angelicae, fructus forsythiae, pepper and rhizoma atractylodis;

the extraction steps of the plant extract comprise: primarily extruding all plant raw materials to be extracted by a press, soaking in water for 20-24 h, heating in 120-degree oil bath for 4-8 h to obtain volatile oil, adding anhydrous ether, standing, filtering, and removing ether by an evaporator to obtain extractive solution.

The active agent is glycerin fatty acid ester, the algefacient is menthol or menthane amide, the antiseptic is phenoxyethanol, and the 2-phenoxyethanol is mixed in water.

step three: gradually adding the first mixed solution into the second mixed solution to obtain the oral cavity bacteriostatic medicine.

Specifically, in the preparation by mixing, the second mixed solution is used as a main base, and the first mixed solution is used as an additive.

An embodiment one of a device for preparing a medicament for oral cavity bacteriostasis, as shown in fig. 1-2 and fig. 5-6, comprises a control panel and a stirring barrel 1, wherein the stirring barrel 1 is provided with a liquid inlet 11 and a liquid outlet 12, the upper end of the stirring barrel 1 is provided with a motor 13, a main shaft 2 in transmission connection with an output shaft of the motor 13 is rotatably arranged in the stirring barrel 1, and a stirring mechanism matched with the main shaft 2 is arranged in the stirring barrel 1;

the stirring mechanism consists of two pumping assemblies which are symmetrically distributed and connected with the main shaft 2 and a pressure applying assembly, the pressure applying assembly comprises two arc-shaped convex plates 21 and a barrier plate 22, the two arc-shaped convex plates 21 are symmetrically arranged at the upper end of the stirring barrel 1, the two arc-shaped convex plates 21 are not connected with each other, and the barrier plate 22 is fixedly connected with the upper side of the main shaft 2;

the pump suction assembly comprises a long column 3, a movable shaft 31, a restorer, two infusion tubes 32 and two piston bodies 33, the middle part of the long column 3 is fixedly connected with a main shaft 2 through a connecting plate, piston cavities 34 are symmetrically formed in the middle part of the long column 3 in an up-and-down mode, the movable shaft 31 is arranged in the long column 3 in a sliding and sealing mode and extends into the two piston cavities 34, one end of the movable shaft 31 penetrates through a blocking plate 22 in a sliding mode, the restorer is connected with the movable shaft 31 and located on the upper side of the blocking plate 22, the two piston bodies 33 are arranged in the two piston cavities 34 in a sliding and sealing mode respectively and are connected with the movable shaft 31, and the two infusion tubes 32 are connected and matched with the two piston cavities 34 respectively.

The two ends of the long column 3, which are far away from each other, are respectively provided with a first one-way liquid inlet valve 35 communicated with the piston cavity 34 on the corresponding side, the liquid conveying pipe 32 comprises a liquid guide pipe 321 and a liquid distribution pipe 322, the liquid guide pipe 321 is communicated with the corresponding piston cavity 34 and is provided with a one-way liquid discharge valve 3212, the liquid distribution pipe 322 is in a semi-annular shape and is communicated with the liquid guide pipe 321, the liquid distribution pipe 322 is uniformly provided with a plurality of liquid discharge ports 12, and the liquid guide pipe 321 is uniformly provided with a plurality of bypass ports 3211 along the length direction.

When the first mixed liquid and the second mixed liquid are mixed, the first mixed liquid and the second mixed liquid are injected into the stirring barrel 1, at the moment, the motor 13 is started through the control panel to carry out stirring treatment, when the output shaft of the motor 13 rotates, the main shaft 2 is driven to rotate, the main shaft 2 rotates to drive the two pumping assemblies to synchronously rotate, in the process, the long column 3 rotates around the main shaft 2 to stir and mix raw materials in the stirring barrel 1, and when the pumping assemblies rotate, the movable shaft 31 is always kept attached to the upper inner wall of the stirring barrel 1 under the pushing of the restorer, the movable shaft 31 is gradually abutted against the arc-shaped convex plate 21 along with continuous rotation of the movable shaft 31, so that the movable shaft 31 is gradually blocked to move, the piston body 33 connected with the movable shaft 31 moves in the corresponding piston cavity 34, the corresponding two piston cavities 34 generate negative-pressure suction force or thrust force, and the piston cavity 34 generating the negative-pressure suction force at the moment sucks liquid in the stirring barrel 1 through the first one-way liquid inlet valve 35 The piston cavity 34 generating the thrust force pumps the air or liquid inside into the mixing tank 1 through the infusion tube 32, and the movable shaft 31 gradually separates from the arc-shaped convex plate 21, the movable shaft 31 moves upwards by matching with the setting of the restorer, and then the two piston bodies 33 are driven to restore, so that the states of the two piston cavities 34 are exchanged, namely the piston cavity 34 generating the suction force when the movable shaft 31 moves downwards generates the thrust force, so that the liquid in the mixing tank 1 can be repeatedly pumped and discharged by the piston cavity 34, and the rapid stirring and mixing in the mixing tank 1 are achieved by repeatedly pumping and discharging the liquid;

in order to further improve the stirring effect, the length of catheter 321 and long post 3 phase-match, and divide liquid pipe 322 to be located the other end of catheter 321, like this in piston chamber 34 pump out liquid and through dividing liquid pipe 322 when discharging, the setting of two piston chambers 34 of cooperation can be with the liquid of upper and lower floor in agitator 1 carry out the interactive mixture to reach the flash mixed of upper and lower floor's liquid, further improve the efficiency and the effect of mixing.

The restorer comprises a return spring 4 and a limiting sheet 41, the limiting sheet 41 is fixedly arranged on the upper side of the movable shaft 31, and the return spring 4 is sleeved on the movable shaft 31 and is positioned between the limiting sheet 41 and the blocking plate 22; the movable shaft 31 is sleeved with a protection ring 42, and the protection ring 42 is positioned between the blocking plate 22 and the return spring 4.

When the movable shaft 31 is affected by the action of the arc-shaped convex plate 21, the arrangement of the limiting sheet 41 can be matched with the blocking plate 22 to compress the return spring 4, and along with the continuous rotation of the pumping assembly, the movable shaft 31 gradually breaks away from the connection with the arc-shaped convex plate 21, at the moment, the return spring 4 loses resistance and gradually stretches and recovers, so that the movable shaft 31 resets, and the protection ring 42 can protect the return spring 4 to avoid the damage between the return spring 4 and the blocking plate 22;

the bypass port 3211 formed in the liquid guide pipe 321 can expand the liquid output range to the length of the whole liquid guide pipe 321 when liquid is output, so that the liquid at the whole height can be further impacted in the liquid output process, and the stirring effect is improved.

Example two:

as shown in fig. 3-4, a further improvement on the first embodiment is that an annular shell 5 is fixedly arranged in the middle of the upper end of the stirring barrel 1, the annular shell 5 is connected with the main shaft 2 in a rotating and sealing manner, a liquid inlet pipe 51 is communicated with the annular shell 5, a liquid delivery channel 52 communicated with the annular shell 5 is arranged in the middle of the main shaft 2, a bypass channel communicated with the liquid delivery channel 52 is arranged on the connecting plate, bypass pipes 5453 connected with the corresponding bypass channels are arranged at both ends of the long column 3, and the bypass pipes 5453 are provided with second one-way liquid inlet valves 55.

In order to further improve the mixing effect of the components, the liquid inlet pipe 51 can be connected to an external storage device, then the first mixed liquid is stored and enters the external storage device, when the components are mixed, the external storage device is opened to inject the first mixed liquid into the annular shell 5, the first mixed liquid in the annular shell 5 is input into the infusion channel 52 and the bypass channel, along with the suction force generated by the movement of the piston body 33 in the piston cavity 34, the second one-way liquid inlet valve 55 is opened by matching with the connection of the bypass pipe 5453, so that the first mixed liquid is pumped into the corresponding piston cavity 34, at the moment, part of the first mixed liquid is mixed with the second mixed liquid pumped into the piston cavity 34, along with the reverse movement of the piston body 33, the thrust force is generated in the piston cavity 34, further, the primarily-fused liquid is injected into the stirring barrel 1 and then fused with the first mixed liquid, and the small amount of multiple times of adding can be beneficial to the control of the overall concentration of the medicine in the stirring barrel 1, avoid single too much to add the appearance concentration and be difficult to control, improve the dispersity of second mixed solution simultaneously, when need not pour into first mixed solution into, can cut off the transport of outside storage device to first mixed solution, with the external intake pipe of feed liquor pipe 51 simultaneously, along with the suction of piston chamber 34 this moment, will make outside gas be sucked in piston chamber 34, and all pump out through transfer line 32 with the liquid and the air in piston chamber 34 under the promotion of piston body 33, the injection of air can produce the come-up bubble in liquid like this, promote the mixture of medicine component.

The foregoing embodiments are merely illustrative of the principles of the present invention and its efficacy, and are not to be construed as limiting the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims

1. A medicament for oral bacteriostasis, which is characterized in that: the oral cavity bacteriostatic medicine is a liquid phase, and the oral cavity bacteriostatic medicine is prepared from edible essence, an active agent, a freshener, a preservative, water and a bacteriostatic combined solution;

the plant extracting solution is prepared from the following components in parts by weight of 15: 5-10: 1-5: 1-5 of radix angelicae, fructus forsythiae, pepper and rhizoma atractylodis;

2. The medicament for oral bacteriostasis according to claim 1, wherein: the active agent is glycerin fatty acid ester, the algefacient can be menthol or menthane carboxamide, the preservative is phenoxyethanol, and the water is mixed with 2-phenoxyethanol.

3. The medicament for oral bacteriostasis according to claim 2, wherein: the components by weight percentage concentration are 0.1-1.5% of edible essence, 0.1-0.2% of active agent, 1-2% of freshener, 0.1-0.2% of preservative, 0.8-25% of bacteriostatic combined liquid and the balance of water.

4. The medicament for oral bacteriostasis according to any one of claims 1 to 3, further comprising a preparation method of the medicament for oral bacteriostasis, wherein the preparation method comprises the following steps:

5. The method for preparing a drug for oral cavity bacteriostasis according to claim 4, further comprising a preparation device for a drug for oral cavity bacteriostasis, which comprises a control panel and a stirring barrel, wherein the stirring barrel is provided with a liquid inlet and a liquid outlet, and is characterized in that: a motor is arranged at the upper end of the stirring barrel, a main shaft in transmission connection with an output shaft of the motor is rotationally arranged in the stirring barrel, and a stirring mechanism matched with the main shaft is arranged in the stirring barrel;

the pump suction assembly comprises a long column, a movable shaft, a restorer, two infusion tubes and two piston bodies, the middle of the long column is fixedly connected with a main shaft through a connecting plate, piston cavities are symmetrically formed in the middle of the long column in the up-down direction, the movable shaft is arranged in a sliding sealing mode and extends into the long column and extends into the two piston cavities, one end of the movable shaft penetrates through the barrier plate in a sliding mode, the restorer is connected with the movable shaft and located on the upper side of the barrier plate, the two piston bodies are arranged in the piston cavities in a sliding sealing mode and connected with the movable shaft, and the infusion tubes are connected with the piston cavities and matched with the piston cavities.

6. The apparatus for preparing a drug for oral bacteriostasis according to claim 5, wherein: the restorer comprises a reset spring and a limiting sheet, the limiting sheet is fixedly arranged on the upper side of the movable shaft, and the reset spring is sleeved on the movable shaft and is located between the limiting sheet and the blocking plate.

7. The apparatus for preparing a drug for oral bacteriostasis according to claim 6, wherein: the movable shaft sleeve is provided with a protection ring, and the protection ring is positioned between the blocking plate and the reset spring.

8. The apparatus for preparing a drug for oral bacteriostasis according to claim 5, wherein: the long column is kept away from both ends mutually and all is equipped with and corresponds the side the first one-way feed liquor valve of piston chamber UNICOM, the transfer line includes catheter and branch liquid pipe, catheter and corresponding piston chamber UNICOM is equipped with one-way flowing back valve, divide the liquid pipe be the semicircle form and with catheter UNICOM, divide the liquid pipe evenly to be equipped with a plurality of leakage fluid ports, the drain pipe is evenly opened along its length direction has a plurality of by pass ports.

9. The apparatus for preparing a drug for oral bacteriostasis according to claim 5, wherein: the middle part of the upper end of the stirring barrel is fixedly provided with an annular shell, the annular shell is connected with the main shaft in a rotating and sealing manner, the annular shell is communicated with a liquid inlet pipe, the middle part of the main shaft is provided with an infusion channel communicated with the annular shell, the connecting plate is provided with a by-pass channel communicated with the infusion channel, two ends of the long column are provided with by-pass pipes connected with the corresponding by-pass channels, and the by-pass pipes are provided with second one-way liquid inlet valves.